Genomes and Genes
Gene Symbol: GNAO1
Description: G protein subunit alpha o1
Alias: EIEE17, G-ALPHA-o, GNAO, HLA-DQB1, guanine nucleotide-binding protein G(o) subunit alpha, GO2-q chimeric G-protein, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, guanine nucleotide-binding regulatory protein 2
Publications165 found, 100 shown here
- GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunitsL de Vries
Division of Cellular and Molecular Medicine, University of California at San Diego, La Jolla 92093 0651, USA
Proc Natl Acad Sci U S A 93:15203-8. 1996..specifically with members of the G alpha i subfamily, G alpha i1, G alpha i2, G alpha i3, G alpha z, and G alpha o, but not with members of other G alpha subfamilies, G alpha s, G alpha q, and G alpha 12/13...
- De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathyKazuyuki Nakamura
Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
Am J Hum Genet 93:496-505. 2013..By whole-exome sequencing and subsequent mutation screening, we identified de novo heterozygous mutations in GNAO1, which encodes a Gαo subunit of heterotrimeric G proteins, in four individuals with epileptic encephalopathy...
- Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunitsRicardo Mostany
Departamento de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Cantabria, Av Herrera Oria s n, E 39011 Santander, Spain
Neuropharmacology 54:989-97. 2008..35S]GTP gamma S binding, mu-agonist-induced adenylyl cyclase inhibition, and co-precipitation of G alpha o, G alpha i2 G alpha z and G alpha q11 subunits with mu-opioid receptors...
- Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigreeMarquis P Vawter
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA 92697 1675, USA
Schizophr Res 67:41-52. 2004..3-q32) and the human guanine nucleotide-binding regulatory protein Go-alpha (GNAO1 localized at 16q13) was significantly decreased in individuals with schizophrenia compared to unaffected family ..
- Identification of protein pheromones that promote aggressive behaviourPablo Chamero
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
Nature 450:899-902. 2007..a sensory neuron subfamily characterized by the expression of the G-protein Galpha(o) subunit (also known as Gnao) and Vmn2r putative pheromone receptors (V2Rs)...
- Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in ratsYounghwa Kim
Department of Anatomy, College of Medicine, Ewha Womans University, Seoul 158 710, Korea
Neurochem Res 27:527-33. 2002..showed that the level of G alpha s mRNA was increased in the septum and brainstem, and the level of G alpha o mRNA was elevated in the cortex during the pentobarbital withdrawal...
- Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* proteinMing Zhu
Division of Cardiology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
Am J Physiol Heart Circ Physiol 294:H1335-47. 2008..To investigate the role of G alpha o in the heart, we generated transgenic mice with cardiac-specific expression of a constitutively active form of G ..
- RGS8 accelerates G-protein-mediated modulation of K+ currentsO Saitoh
Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
Nature 390:525-9. 1997..This property of RGS8 may be crucial for the rapid regulation of neuronal excitability upon stimulation of G-protein-coupled receptors...
- Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brainK P Lesch
Section of Neuropharmacology, National Institute of Mental Health, Bethesda, Maryland
Biol Psychiatry 32:549-79. 1992..long-term administration of a wide spectrum of antidepressant drugs regulate G alpha s, G alpha i1, G alpha i2, G alpha o, G alpha q, and G alpha 12 mRNA and protein expression in various areas of the rat brain...
- G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cellsLiquan Huang
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
J Comp Neurol 455:1-10. 2003..Gbeta1, 2, and 5 are expressed in partially overlapping subpopulations of cone bipolar cells. Ggamma13 and Gbeta3 and/or Gbeta4, thus, seem selectively to participate in signal transduction by ON bipolar cells...
- Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channelYing Zhao
Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
J Biol Chem 283:5306-16. 2008..antisera raised against alpha and beta subunits (anti-G alpha common, anti-G beta, anti-G alpha i1/2/3, and anti-G alpha o) were used. Anti-G alpha common totally blocked the effects of NE on membrane potential and K ATP channels...
- Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neuronesM P Caulfield
Wellcome Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London
J Physiol 477:415-22. 1994..2. Antibodies specific for G alpha q/11, but not those for G alpha o, reduced M-current inhibition by the muscarinic agonist oxotremorine-M, whereas anti-G alpha o antibodies, but ..
- Involvement of cholesterol in synaptic vesicle swellingJin Sook Lee
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Exp Biol Med (Maywood) 235:470-7. 2010..Our study further demonstrates that this effect of cholesterol is due, in part, to its involvement in the interactions between AQP-6, vH(+)-ATPase and the GTP-binding G(alpha o) protein at the synaptic vesicle membrane...
- G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gatingA Terzic
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905
Neuron 12:885-93. 1994..Active forms of exogenous G protein subunits (G alpha i-1, G alpha i-2, or G alpha o) activated only KATP channels closed by ATPi...
- Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPIIJ Dedrick Jordan
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 280:11413-21. 2005..Thus, the G(alpha)o/i-coupled cannabinoid receptor, by regulating the proteasomal degradation of Rap1GAPII, activates Rap1 to induce neurite outgrowth...
- Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha oJ C Lang
Abt Neuropharmakologie, Max Planck Institut fur Psychiatrie, Martinsried, FRG
J Recept Res 9:313-29. 1989..i2 was investigated in plasma membranes from different tissues and cells and compared to the distribution of G alpha o and other pertussis toxin sensitive G alpha...
- Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in miceB Kest
Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
Neuroscience 162:1255-64. 2009..The most salient candidate gene within this QTL, Gnao1 (guanine nucleotide binding protein, alpha(o); G alpha(o); 96...
- Developmental expression of G alpha o and G alpha s isoforms in PC12 cells: relationship to neurite outgrowthS Andreopoulos
Section of Biochemical Psychiatry, Clarke Institute of Psychiatry, University of Toronto, Ont, Canada
Brain Res Dev Brain Res 88:30-6. 1995..Furthermore, no significant changes were observed in the levels of alpha o or alpha s isoforms following NGF removal. These findings suggest that alpha o isoforms are involved in neuritic extension in PC12 cells...
- Isolation and expression of a novel chick G-protein cDNA coding for a G alpha i3 protein with a G alpha 0 N-terminusE J Kilbourne
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
Biochem J 297:303-8. 1994..sequence in which the first 45 amino acids coded for are 100% identical to the conserved N-terminus of G alpha o from species such as rat, mouse, human, bovine and hamster...
- Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonistsJ Gomeza
UPR Centre Nationale de Recherche Scientifique 9023, Mecanismes Moleculaires des Communications Cellulaires, CCIPE, Montpeller, France
Mol Pharmacol 50:923-30. 1996..Furthermore, the exchange of a few carboxyl-terminal residues of G alpha q by those of G alpha 12 or G alpha o allows the resulting chimeric G alpha subunits (G alpha ql and G alpha qol respectively) to couple Gi-coupled ..
- Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3W van't Hof
Cell Biology and Genetics Program, Sloan Kettering Institute for Cancer Research, New York, NY 10021, USA
J Cell Biol 136:1023-35. 1997..These results serve to define a novel trafficking pathway for Src family proteins that are regulated by dual fatty acylation...
- Serotonin-mediated palmitoylation and depalmitoylation of G alpha proteins in rat brain cortical membranesS Bhamre
Laboratory of Molecular Pharmacology, Department of Pharmacology, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA
J Pharmacol Exp Ther 286:1482-9. 1998....
- Reductions in binding and functions of D2 dopamine receptors in the rat ventral striatum during amphetamine sensitizationJ C Chen
Department of Pharmacology, Chang Gung University, Tao Yuan, Taiwan, ROC
Life Sci 64:343-54. 1999..The decreases in D2 receptor function were unrelated to the coupled G-proteins, since none of the G alpha i-3, G alpha o or G alpha q in the ventral striatum exhibited quantitative differences between control and amphetamine ..
- Modest cholinergic deafferentation fails to alter hippocampal G-proteinsM McLaughlin
Neuroscience Institute, Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, UK
Neurochem Int 35:59-64. 1999....
- Involvement of G(q/11) in signal transduction in the mammalian vomeronasal organKennedy S Wekesa
Alabama State University, Biomedical Research and Training Programs, Montgomery, AL 36104 0271, USA
J Exp Biol 206:827-32. 2003..Our observations indicate that pheromones in male urine act on vomeronasal neurons in the female VNO via a receptor-mediated, G alpha(q/11)-protein-dependent increase in IP(3) levels...
- A retinal-specific regulator of G-protein signaling interacts with Galpha(o) and accelerates an expressed metabotropic glutamate receptor 6 cascadeAnuradha Dhingra
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058, USA
J Neurosci 24:5684-93. 2004..This would tend to match its kinetics to that of the OFF bipolar that arises directly from ligand-gated channels...
- Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptorHeng Xu
Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224 2735, USA
J Pharmacol Exp Ther 315:248-55. 2005..chronic morphine treatment decreased the expression of G alpha i2 (64%) and G alpha i3 (60%), had no effect of G alpha o, and increased G alpha12 (66%) expression in Chinese hamster ovary (CHO) cells expressing the cloned human mu ..
- The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3John Cijiang He
Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 280:33426-34. 2005..Overall, this study demonstrated that G alpha(o/i)-coupled CB1R triggers neurite outgrowth in Neuro-2A through the activation of a signaling network containing two pathways that bifurcate at Src and converge at Stat3...
- GPCR signaling is required for blood-brain barrier formation in drosophilaTina Schwabe
Laboratory of Developmental Neurogenetics, Rockefeller University, New York, NY 10021, USA
Cell 123:133-44. 2005..Here, we show that the G protein-coupled receptor (GPCR) Moody, the G protein subunits G alpha i and G alpha o, and the regulator of G protein signaling Loco are required in the surface glia to achieve effective insulation...
- Heterotrimeric G proteins precouple with G protein-coupled receptors in living cellsMuriel Nobles
British Heart Foundation Laboratories and Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
Proc Natl Acad Sci U S A 102:18706-11. 2005..Our work suggests that GPCR dimers and the G protein heterotrimer are present at the cell membrane in the resting state in a pentameric complex...
- Expression of a vomeronasal receptor gene (V1r) and G protein alpha subunits in goat, Capra hircus, olfactory receptor neuronsYoshihiro Wakabayashi
Laboratory of Cell Biology and Anatomy, Department of Neuroscience Basic Technology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
J Comp Neurol 503:371-80. 2007..by ORNs, whereas two vomeronasal receptor families (V1rs and V2rs) coupled respectively to G alpha i2 and G alpha o, are expressed by VRNs. Previously, we reported that one goat V1rs (gV1ra1) is expressed by ORNs and VRNs...
- G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cellsRama Kamesh Bikkavilli
Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Sci 121:234-45. 2008..The canonical WNT-beta-catenin signaling pathway requires both G alpha o and G alpha q heterotrimeric G-proteins, whereas we show that WNT-JNK signaling requires only G alpha o protein...
- Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organStephen D Liberles
Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 106:9842-7. 2009..Given the presence of formylated peptides in bacteria and mitochondria, possible roles for VNO FPRs include the assessment of conspecifics or other species based on variations in normal bacterial flora or mitochondrial proteins...
- The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathwayDiane Egger-Adam
Department of Biology, University of Konstanz, Konstanz, Germany
Dev Dyn 239:168-83. 2010..b>G alpha o physically binds Axin and re-localizes it to the plasma membrane...
- Gαo potentiates estrogen receptor α activity via the ERK signaling pathwayMelyssa R Bratton
Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL 78, New Orleans, Louisiana 70112, USA
J Endocrinol 214:45-54. 2012..In summary, our results show that Gα(o), through activation of the MAPK pathway, plays a role in the regulation of ERα activity...
- Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptorsMary E Hamby
Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 32:14489-510. 2012..involved in calcium signaling were significantly regulated, mostly down (for example, Cxcr4, Adra2a, Ednra, P2ry1, Gnao1, Gng7), but some up (for example, P2ry14, P2ry6, Ccrl2, Gnb4)...
- Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosisZhen Liu
Department of Digestive Diseases, Southeast Hospital, Xiamen University, Zhangzhou, Fujian, P R China
Int J Mol Med 33:589-96. 2014Guanine nucleotide-binding protein (G protein), alpha activating activity polypeptide O (GNAO1) encodes an alpha subunit of the heterotrimeric guanine nucleotide-binding proteins (Gαo), which plays a significant role in the development ..
- Simultaneous deletion of floxed genes mediated by CaMKIIα-Cre in the brain and in male germ cells: application to conditional and conventional disruption of GoαChan Il Choi
1 Departments of Anatomy, Ajou University, School of Medicine, Suwon, South Korea 2 Neuroscience Graduate Program, Ajou University, School of Medicine, Suwon, South Korea 3 BK21 Division of Cell Transformation and Restoration, Ajou University, School of Medicine, Suwon, South Korea
Exp Mol Med 46:e93. 2014..Similarly, when double transgenic Gnao(+/f)::CaMKIIα-Cre(+/Cre) mice carrying a floxed Go-alpha gene (Gnao(f/f)) were backcrossed to wild-type females, ..
- Harnessing gene expression networks to prioritize candidate epileptic encephalopathy genesKaren L Oliver
Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia Epilepsy Research Center, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
PLoS ONE 9:e102079. 2014..the nineteen genes that we predicted with the highest likelihood to be true Epileptic Encephalopathy genes, two (GNAO1 and GRIN2B) have recently been independently reported and confirmed...
- Phenotypic spectrum of GNAO1 variants: epileptic encephalopathy to involuntary movements with severe developmental delayHirotomo Saitsu
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Eur J Hum Genet 24:129-34. 2016De novo GNAO1 variants have been found in four patients including three patients with Ohtahara syndrome and one patient with childhood epilepsy...
- Identification of a Novel Gnao-Mediated Alternate Olfactory Signaling Pathway in Murine OSNsPaul Scholz
Department of Cell Physiology, Ruhr University Bochum Bochum, Germany
Front Cell Neurosci 10:63. 2016..Interestingly, this pathway is mediated by Gnao activation, leading to Cl(-) efflux; however, the activation of adenylyl cyclase III (ACIII), the recruitment of Ca(..
- A central role for R7bp in the regulation of itch sensationMritunjay Pandey
1Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 2North Carolina State University, College of Veterinary Medicine, Department of Molecular Biomedical Sciences, Raleigh, NC 3Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 4Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 5Molecular Genetics Unit, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
Pain . 2017..Knock-in to mice of a GTPase activating protein-insensitive mutant of Gαo (Gnao1 G184S/+) produces a similar pruriceptive phenotype...
- Molecular cloning and sequence determination of four different cDNA species coding for alpha-subunits of G proteins from Xenopus laevis oocytesJ Olate
Departamento de Bioquimica, Facultad de Medicina, Universidad de Chile, Santiago
FEBS Lett 268:27-31. 1990..In addition to a clone coding for a G alpha o-type subunit previously reported [(1989) FEBS Lett...
- A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunitsJ Chen
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, NY 10029, USA
Science 268:1166-9. 1995..of calmodulin-stimulated adenylyl cyclases, but had no effect on interactions between G beta gamma and G alpha o. Substitutions in this peptide identified a functionally important motif, Gln-X-X-Glu-Arg, that is also ..
- Expression of G proteins in human placentas from pregnancies complicated by gestational hypertensionA Petit
Department of Obstetrics and Gynecology, University of Montreal, Research Center, Ste Justine Hospital, Quebec, Canada
Life Sci 60:953-60. 1997..Specifically, G alpha i2, G alpha i3, G alpha o, G alpha s, and G alpha q/11 levels reached 87%, 81%, 91%, 99%, and 103% respectively of those from normal ..
- G-protein expression in melanotropes changes coincident with innervation of the developing rat pituitary intermediate lobeS A Sands
School of Biological Sciences, University of Missouri Kansas City 64108, USA
Int J Dev Neurosci 15:329-41. 1997..Using immunohistochemistry, this study examined expression of G alpha i1/2, G alpha i3, G alpha o and G alpha s proteins before and after dopaminergic innervation...
- Activation and inhibition of G proteins by lipoaminesEvelyn Breitweg-Lehmann
Institute of Pharmacology, Berlin Free University, Berlin, Germany
Mol Pharmacol 61:628-36. 2002..In the presence of G beta gamma, they rather antagonize G protein-coupled receptor signaling...
- M1 muscarinic receptor signaling in mouse hippocampus and cortexAmy C Porter
Lilly Research Laboratories, Neuroscience Research Division, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
Brain Res 944:82-9. 2002..These findings support a role for the M1 receptor subtype as the primary G(alpha)(q)/11-coupled muscarinic receptor in mouse hippocampus and cortex...
- Selective G protein beta gamma-subunit compositions mediate phospholipase C activation in the vomeronasal organKarin Rünnenburger
Department of Pharmacology and Toxicology, University of Ulm, Germany
Eur J Cell Biol 81:539-47. 2002....
- Mechanism of action of Gq to inhibit G beta gamma modulation of CaV2.2 calcium channels: probed by the use of receptor-G alpha tandemsFederica Bertaso
Department of Pharmacology, University College London, London, United Kingdom
Mol Pharmacol 63:832-43. 2003..The potential sites of phosphorylation are discussed...
- Vomeronasal phenotype and behavioral alterations in G alpha i2 mutant miceE Marianne Norlin
Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
Curr Biol 13:1214-9. 2003..The significance of this dichotomy is largely unknown. VN neurons express high levels of either G alpha i2 or G alpha o. A mouse line carrying a targeted disruption of the G alpha i2 gene offered the opportunity for studying the ..
- Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mappingJoseph A Cioffi
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Acta Otolaryngol 123:1027-34. 2003..The purpose of this study was to better define the role of these proteins by examining their expression in the rat vestibular periphery and characterizing their chromosomal location...
- Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegansSatoshi Suo
Department of Psychiatry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5T 1R8
J Neurosci 26:10082-90. 2006..The results show that the endogenous octopamine system in C. elegans is activated by starvation and that different environmental stimuli can activate CREB through G alpha(q)...
- 17beta-Oestradiol stimulation of G-proteins in aged and Alzheimer's human brain: comparison with phytoestrogensV Jefremov
Department of Biochemistry, Tartu University, Tartu, Estonia
J Neuroendocrinol 20:587-96. 2008..Both of these mechanisms could be involved in the neuroprotective signalling of oestrogens that contributes to their preventive/therapeutic action against postmenopausal neurological disorders...
- Localization of G protein alpha subunits and morphology of receptor neurons in olfactory and vomeronasal epithelia in Reeve's turtle, Geoclemys reevesiiYoshihiro Wakabayashi
Laboratory of Cell Biology and Anatomy, Department of Neuroscience Basic Technology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
Zoolog Sci 25:178-87. 2008..In rodents, signal transduction pathways involve G alpha olf and G alpha i2/G alpha o in OE and VNE, respectively. Reeve's turtles (Geoclemys reevesii) live in a semiaquatic environment...
- Novel peptide ligands of RGS4 from a focused one-bead, one-compound libraryRebecca A Roof
Department of Pharmacology, University of Michigan, 1301 MSRB III SPC5632, Ann Arbor, MI 48103, USA
Chem Biol Drug Des 72:111-9. 2008..Peptide 2 has been modeled to fit in the same binding pocket predicted for YJ34 but in the reverse orientation...
- RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11Yasar Saleem
Center for Neural Science, Korea Institute of Science and Technology KIST, P O BOX 131, Cheongryang, Seoul 130 650, Republic of Korea
Biochem Biophys Res Commun 386:65-70. 2009..In addition, we identified a novel interaction between Galpha(oa) and R7BP with a K(D) of 592 (+/- 150) nM. The production of stable and functional rRGS11 would provide chances to discover more functions of RGS11 yet to be identified...
- Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindnessDonald Beqollari
Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Mol Pharmacol 76:992-7. 2009..Most importantly, our results indicate a switch in G-protein coupling, in which E775K loses G(o) coupling but retains coupling to G(i), which may explain the phenotype...
- PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiologyKelly L McCoy
Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Pharmacol 77:1005-15. 2010..These studies demonstrate that PAR1 and PAR2 physically and functionally link to overlapping and distinct profiles of G proteins to differentially regulate downstream signaling pathways and cell physiology...
- Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophreniaHidenaga Yamamori
Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
J Hum Genet 56:478-83. 2011..In this study, we measured the mRNA expression levels of dysbindin-1, NRG-1 and two other genes (NPY1R and GNAO1) in immortalized lymphocytes from 45 patients with schizophrenia and 45 controls using real-time quantitative ..
- Predicting the diagnosis of autism spectrum disorder using gene pathway analysisE Skafidas
Centre for Neural Engineering, The University of Melbourne, Parkville, Vic, Australia
Mol Psychiatry 19:504-10. 2014..4%) in a genetically dissimilar Han Chinese cohort (HAN). Eight SNPs in three genes (KCNMB4, GNAO1, GRM5) had the largest effect in the classifier with some acting as vulnerability SNPs, whereas others were ..
- Intra-familial tests of association between familial idiopathic scoliosis and linked regions on 9q31.3-q34.3 and 16p12.3-q22.2Nancy H Miller
Department of Orthopaedic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Hum Hered 74:36-44. 2012....
- Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinomaP N Valdmanis
1 Department of Pediatrics, Stanford University, Stanford, CA, USA 2 Department of Genetics, Stanford University, Stanford, CA, USA
Oncogene 34:94-103. 2015..This includes the repression of a network of GTPase-related genes (Prkg1, Gnao1 and Rgs9) in tumor samples and an enrichment of Apobec1-mediated cytosine to uridine RNA editing...
- Alternative splicing regulation of APP exon 7 by RBFox proteinsShafiul Alam
School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan Electronic address
Neurochem Int 78:7-17. 2014..precursor protein (APP), disks large homolog 3 (DLG3), and G protein, alpha activating activity polypeptide O (GNAO1), was altered by transient RBFox1 expression in HEK293 and HeLa cells...
- Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approachKlemen Zupancic
Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia
Radiol Oncol 48:257-66. 2014..The aim of this study was to define the impact of GBM in terms of alterations of the plasma protein levels in these patients...
- Innate Predator Odor Aversion Driven by Parallel Olfactory Subsystems that Converge in the Ventromedial HypothalamusAnabel Pérez-Gómez
Department of Physiology and Center for Integrative Physiology and Molecular Medicine, University of Saarland School of Medicine, 66421 Homburg, Germany
Curr Biol 25:1340-6. 2015..responses in specific subsystems through disruption of genes encoding key sensory transduction proteins (Cnga3, Gnao1) or by surgical axotomy abolished avoidance behaviors and/or cellular Ca(2+) responses to different predator odors...
- Ophthalmic Alterations in the Sturge-Weber Syndrome, Klippel-Trenaunay Syndrome, and the Phakomatosis Pigmentovascularis: An Independent Group of Conditions?Solmaz Abdolrahimzadeh
Ophthalmology Unit, DAI Head Neck, Umberto I Policlinic, University of Rome Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
Biomed Res Int 2015:786519. 2015..circulation, neural crest alterations leading to alterations of autonomic perivascular nerves, mutation of the GNAO gene in the Sturge-Weber syndrome, PIK3CA mutation in malformative/overgrowth syndromes such as the Klippel-..
- Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsyChun Yiu Law
Department of Pathology, The University of Hong Kong, Hong Kong, China
Clin Chim Acta 451:292-6. 2015..The cause of infantile-onset epilepsy is complex and is not easily recognized clinically, particularly in paediatric patients who present with non-specific neurological signs, no radiological abnormalities and no metabolic changes...
- Clinical Course of Six Children With GNAO1 Mutations Causing a Severe and Distinctive Movement DisorderAmitha L Ananth
Department of Pediatrics, Stanford University, Stanford, California Electronic address
Pediatr Neurol 59:81-4. 2016Mutations in GNAO1 have been described in 11 patients to date. Although most of these individuals had epileptic encephalopathy, four patients had a severe movement disorder as the prominent feature...
- Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cellsMeiling Jin
Center for Diabetes, Obesity and Metabolism, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, Guangdong Province 518060, China
Integr Biol (Camb) 8:968-75. 2016..Taken together, the data presented here suggest that TLR2 activation in human mast cells promotes the release of inflammatory mediators via distinct signaling pathways that partially depend on the action of Go proteins. ..
- Recurrent GNAO1 Mutations Associated With Developmental Delay and a Movement DisorderLeonie A Menke
Department of Pediatrics, Academic Medical Center, Amsterdam, The Netherlands
J Child Neurol 31:1598-1601. 2016..developmental delay and a hyperkinetic movement disorder, a missense mutation was found in codon 209 of the GNAO1 gene. From the still scarce literature on GNAO1 mutations, a clear genotype-phenotype correlation emerged...
- A case of severe movement disorder with GNAO1 mutation responsive to topiramateSaori Sakamoto
Department of Pediatrics, Jichi Medical University, Tochigi, Japan
Brain Dev . 2016We report the case of a 19-year-old female patient who had progressive chorea associated with a GNAO1 mutation...
- Functional coupling of the human dopamine D2 receptor with G alpha i1, G alpha i2, G alpha i3 and G alpha o G proteins: evidence for agonist regulation of G protein selectivityLucien Gazi
School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, RG6 6AJ
Br J Pharmacol 138:775-86. 2003..5) We conclude that the degree of selectivity of G protein activation by the D(2L) receptor can depend on the conformation of the receptor stabilised by an agonist...
- Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signalingBritta Settmacher
Department of Medical Microbiology, Medical School Hannover, Hannover, Germany
Eur J Immunol 33:920-7. 2003....
- Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHDD Turic
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD...
- Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of LangerhansPaloma Alonso-Magdalena
Institute of Bioengineering, Miguel Hernandez University, Sant Joan d Alacant, Alicante, Spain
Environ Health Perspect 113:969-77. 2005..The effects triggered by BPA, DES, and E2 are blocked by the G alpha i- and G alpha o-protein inhibitor pertussis toxin, by the guanylate cyclase-specific inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]..
- Role of G proteins and ERK activation in hemin-induced erythroid differentiation of K562 cellsBahire Kucukkaya
Marmara University School of Medicine, Department of Biophysics, Tibbiye Caddesi No 49, Haydarpasa, 34668, Istanbul, Turkey
Life Sci 78:1217-24. 2006..Our results suggest that changes in G protein expression and ERK2 activity are involved in hemin-induced differentiation of K562 cells...
- New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomicsArulmani Manavalan
School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
J Proteomics 75:2468-79. 2012..the brain protein metabolism at the proteome level by down-regulating the expressions of various proteins, such as Gnao1 and Dctn2, which are related to neuronal growth cone control and synaptic activities...
- Pathways involved in sasang constitution from genome-wide analysis in a Korean populationBu Yeo Kim
Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
J Altern Complement Med 18:1070-80. 2012..However, to understand the biologic mechanisms underlying constitution, a comprehensive approach that combines individual genetic effects was applied...
- Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulatorG Berstein
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
Cell 70:411-8. 1992..Such GAP activity by an effector coupled to a trimeric G protein can reconcile slow GTP hydrolysis by pure G proteins in vitro with fast physiologic deactivation of G protein-mediated signaling...
- Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactionsB M Denker
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
J Biol Chem 267:6272-7. 1992..Deletion of this region diminishes the ability of alpha o to interact with the beta gamma subunit, but substitutions at this position indicate that other amino acids can be tolerated without affecting subunit interaction...
- Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptorM Cormont
Unit 145, National Institute of Health and Medical Research, Faculty of Medicine, Nice, France
Diabetes 40:1170-6. 1991..at concentrations where there were no effects of other antibodies specifically directed against Gi alpha 3 or G alpha o. These data suggest that Gi1 and/or Gi2 interact with the galanin receptor and probably mediate the effects of ..
- Ultrastructural localization of the GTP-binding protein Go in neuronsJ Gabrion
Laboratoire de Neurobiologie Endocrinologique, UA 1197 CNRS, Universite de Montpellier II, France
Cell Signal 1:107-23. 1989....
- Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alphaS Lavu
Biological Response Modifiers Program, National Cancer Institute Frederick Cancer Research Facility, MD 21701
Biochem Biophys Res Commun 150:811-5. 1988..There is 100% identity at the amino acid level for the cholera and pertussis toxin-catalyzed ADP ribosylation sites, the putative guanine nucleotide binding, and the GTP hydrolysis sites...
- Voltage-dependent calcium channel beta-subunits in combination with alpha 1 subunits, have a GTPase activating effect to promote the hydrolysis of GTP by G alpha o in rat frontal cortexV Campbell
Department of Pharmacology, Royal Free Hospital School of Medicine, London, UK
FEBS Lett 370:135-40. 1995..This may be a mechanism by which calcium channels can normally act to limit the duration of a G-protein modulatory signal...
- Expression of GTP-binding protein alpha subunits in human thymocytesP S Kabouridis
Department of Biology, San Diego State University, CA 92182, USA
Mol Cell Biochem 144:45-51. 1995..The alpha subunit genes identified are: G alpha i1-3 and G alpha z but not G alpha o from the Gi family, G alpha s from the Gs family, G alpha 11, G alpha q, and G alpha 16 from the Gq family, and ..
- Association of heterotrimeric GTP binding regulatory protein (Go) with mitosisH C Wu
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
Lab Invest 71:175-81. 1994..In the present study, we have conducted experiments to examine whether the G alpha subunit is also associated with mitotic spindles...
- Identification of GTP-binding proteins in human glomeruliK Nitta
Department of Medicine, Kidney Center, Tokyo Women s Medical College, Japan
Nihon Jinzo Gakkai Shi 36:9-12. 1994..This is the first report that characterizes G-protein subunits in human glomeruli. Further study is required to determine the roles of G-proteins in signal transductions in human glomeruli...
- In situ hybridization reveals specific increases in G alpha s and G alpha o mRNA in discrete brain regions of morphine-tolerant ratsD Parolaro
Institute of Pharmacology, Faculty of Sciences, University of Milan, Italy
Eur J Pharmacol 244:211-22. 1993..significantly increased alpha s amounts in the hypothalamus (70%), and produced a minor elevation (30%) in G alpha o levels in the olfactory area...
- The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2M A Wall
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
Cell 83:1047-58. 1995..Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade...
- Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approachL Rambhatla
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Mol Reprod Dev 41:314-24. 1995..we analyzed the patterns of expression of nine G protein alpha subunit mRNAs (G alpha s, G alpha i, G alpha q, G alpha o, and G alpha 11-15) in oocytes, eggs, and preimplantation embryos from fertilization to the blastocyst stage...
- Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells: activation of a G(alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2BL A Obosi
School of Biological and Molecular Sciences, Oxford Brookes University, UK
FEBS Lett 381:233-6. 1996..Immunoblot analysis of the endogenous G-proteins revealed that Sf9 cells lack the G-protein subtypes G(alpha i 1-3) and G(alpha)o, but express the subtype G(alpha)s and G(alpha)q...
- Effect of thyroid deficiency on Go alpha-subunit isoforms in developing rat cerebral cortexP P Li
Section of Biochemical Psychiatry, Clarke Institute of Psychiatry, University of Toronto, Ontario, Canada
Neurochem Res 20:1249-55. 1995Postnatal development of G alpha o isoforms in rat cerebral cortex was studied by SDS-PAGE and immunoblotting...
- Evidence for the coupling of Gq protein to D1-like dopamine sites in rat striatum: possible role in dopamine-mediated inositol phosphate formationH Y Wang
Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129, USA
Mol Pharmacol 48:988-94. 1995..Furthermore, antisera directed against G alpha s or G alpha q but not G alpha i, G alpha o, or G alpha z precipitated specific D1-like binding sites labeled with [3H]SCH23390...
- Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasmsN Kawano
Department of Pathology, Yokohama City University School of Medicine, Japan
Pathol Int 46:393-8. 1996..The biological significance of Go alpha is unclear in normal and neoplastic lung tissues, but Go alpha is a useful marker of neuroendocrine cells and neoplasma of the lung...
- Palmitoylation of p59fyn is reversible and sufficient for plasma membrane associationA Wolven
Program in Molecular Biology, Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
Mol Biol Cell 8:1159-73. 1997..Substitution of the SH4 motif within Fyn with heterologous sequences from other palmitoylated proteins (G alpha o and GAP43) revealed that the presence of palmitate is sufficient to direct plasma membrane localization ..
- A multigene family encoding a diverse array of putative pheromone receptors in mammalsH Matsunami
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 90:775-84. 1997..However, a dramatically different structure for VRs and the existence of variant VR mRNA forms indicate that there are diverse strategies to detect functionally distinct sensory stimuli...
- Analysis of the N-terminal binding domain of Go alphaL Busconi
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Biochem J 328:23-31. 1997..A detailed understanding of G alpha-membrane interactions may reveal unique mechanisms for regulating signal transduction...
- Reduced adenosine A1 receptor and G alpha protein coupling in rat ventricular myocardium during agingG Cai
Department of Pharmacology, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USA
Circ Res 81:1065-71. 1997..ventricular membranes, specific [3H]DPCPX binding sites were detected in immunoprecipitates of G alpha i3 and G alpha o antisera but not with antibodies for other G alpha proteins...
- Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membraneK M Druey
Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
J Biol Chem 273:18405-10. 1998....
- Activation of Go-proteins by membrane depolarization traced by in situ photoaffinity labeling of galphao-proteins with [alpha32P]GTP-azidoanilideY Anis
Department of Physiology and The Cardiac Research Institute, Sackler School of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
J Biol Chem 274:7431-40. 1999..These findings support a possible involvement of VGSC in depolarization-induced activation of Go-proteins...
- EXTRAMURAL RESEARCH FACILITIEIS CONSTRUCTIONJohn Raymond; Fiscal Year: 2002..Total project cost is $4,212,617, of which the University's share is 53 percent. ..
- NADPH OXIDASE & MESANGIAL CELL PROLIFERATION & FIBROSISJohn Raymond; Fiscal Year: 2003..Number 2. To establish a role for ROS generated by NAD(P)H oxidase in an animal model of proliferative and fibrotic renal disease. ..
- EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONJohn Raymond; Fiscal Year: 2003..The total project cost is $6,342,887; the University is contributing $3,171,443 (50 percent). ..
- Human Subjects Research Enhancements Program at MUSCJohn Raymond; Fiscal Year: 2003..abstract_text> ..
- Regulation of EGF Receptors by G protein receptorJohn Raymond; Fiscal Year: 2004..These studies address important gaps in our knowledge of GPCR signals that regulate the functions of RTK's. ..
- Biomarker Genes in Mood Disorder: Lymphocyte and BrainMARQUIS VAWTER; Fiscal Year: 2006..The potential use of biomarkers in lymphocytes will provide clinical researchers a tool to better address questions concerning diagnostic subgroups and treatment responders and non-responders. ..
- Mechanisms of Regulation Of NHE-1John Raymond; Fiscal Year: 2007..This proposal could also lay the foundation for future structural experiments utilizing NMR and/or crystallography methods. ..