GNAO1

Summary

Gene Symbol: GNAO1
Description: G protein subunit alpha o1
Alias: EIEE17, G-ALPHA-o, GNAO, HLA-DQB1, guanine nucleotide-binding protein G(o) subunit alpha, GO2-q chimeric G-protein, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, guanine nucleotide-binding regulatory protein 2
Species: human

Top Publications

  1. pmc GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits
    L de Vries
    Division of Cellular and Molecular Medicine, University of California at San Diego, La Jolla 92093 0651, USA
    Proc Natl Acad Sci U S A 93:15203-8. 1996
  2. pmc De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy
    Kazuyuki Nakamura
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    Am J Hum Genet 93:496-505. 2013
  3. doi Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits
    Ricardo Mostany
    Departamento de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Cantabria, Av Herrera Oria s n, E 39011 Santander, Spain
    Neuropharmacology 54:989-97. 2008
  4. ncbi Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA 92697 1675, USA
    Schizophr Res 67:41-52. 2004
  5. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
  6. ncbi Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats
    Younghwa Kim
    Department of Anatomy, College of Medicine, Ewha Womans University, Seoul 158 710, Korea
    Neurochem Res 27:527-33. 2002
  7. doi Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein
    Ming Zhu
    Division of Cardiology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Am J Physiol Heart Circ Physiol 294:H1335-47. 2008
  8. ncbi RGS8 accelerates G-protein-mediated modulation of K+ currents
    O Saitoh
    Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Nature 390:525-9. 1997
  9. ncbi Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain
    K P Lesch
    Section of Neuropharmacology, National Institute of Mental Health, Bethesda, Maryland
    Biol Psychiatry 32:549-79. 1992
  10. ncbi G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells
    Liquan Huang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 455:1-10. 2003

Research Grants

Scientific Experts

  • Neil Kulkarni
  • Shafiul Alam
  • Arunkumar Krishnan
  • Bu Yeo Kim
  • Satoshi Suo
  • M McLaughlin
  • John Raymond
  • J C Chen
  • MARQUIS VAWTER
  • C C Wong
  • Mariko Kinoshita
  • Mikel Garcia-Marcos
  • Kennedy S Wekesa
  • John Keane
  • P J Pauwels
  • B Kest
  • O Saitoh
  • Amy C Porter
  • Laurence Lanfumey
  • Pablo Chamero
  • Hitoshi Osaka
  • Noriko Miyake
  • Hirotomo Saitsu
  • Naomichi Matsumoto
  • Kazuyuki Nakamura
  • Lutz Birnbaumer
  • Yoshihiro Wakabayashi
  • Mritunjay Pandey
  • Saori Sakamoto
  • Paul Scholz
  • Yukifumi Monden
  • Ryoko Fukai
  • Hiroshi Saito
  • Amitha L Ananth
  • Takanori Yamagata
  • Meiling Jin
  • Leonie A Menke
  • Anabel Pérez-Gómez
  • P N Valdmanis
  • Solmaz Abdolrahimzadeh
  • Chun Yiu Law
  • Masaaki Shiina
  • Kazuhiro Ogata
  • Yoshinori Tsurusaki
  • Mitsuko Nakashima
  • E Skafidas
  • Zhen Liu
  • Karen L Oliver
  • Tracy Nguyen
  • Klemen Zupancic
  • Chan Il Choi
  • J Dedrick Jordan
  • Ravi Iyengar
  • Frank Zufall
  • Trese Leinders-Zufall
  • John Cijiang He
  • Richard R Neubig
  • Arulmani Manavalan
  • Melyssa R Bratton
  • Nancy H Miller
  • Mary E Hamby
  • Heidi E Hamm
  • Hidenaga Yamamori
  • Haeyoung Suh-Kim
  • Can Hasdemir
  • Kelly L McCoy
  • Jeonghan Kim
  • Diane Egger-Adam
  • Pyroja Sulaiman
  • Zhengyan Kan
  • Jin Sook Lee
  • Yasar Saleem
  • Yan Cao
  • Paul J Kammermeier
  • Stephen D Liberles
  • Donald Beqollari
  • Yuanrong Yao
  • Ming Zhu
  • Tomohiro Ishii
  • Mario Pagano
  • Rama Kamesh Bikkavilli
  • Ricardo Mostany
  • Ying Zhao
  • Jung Hee Won
  • Hitoshi Kuwata
  • Rebecca A Roof
  • V Jefremov
  • Masumi Ichikawa
  • Antony M Jose
  • Noga Vardi

Detail Information

Publications165 found, 100 shown here

  1. pmc GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits
    L de Vries
    Division of Cellular and Molecular Medicine, University of California at San Diego, La Jolla 92093 0651, USA
    Proc Natl Acad Sci U S A 93:15203-8. 1996
    ..specifically with members of the G alpha i subfamily, G alpha i1, G alpha i2, G alpha i3, G alpha z, and G alpha o, but not with members of other G alpha subfamilies, G alpha s, G alpha q, and G alpha 12/13...
  2. pmc De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy
    Kazuyuki Nakamura
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    Am J Hum Genet 93:496-505. 2013
    ..By whole-exome sequencing and subsequent mutation screening, we identified de novo heterozygous mutations in GNAO1, which encodes a Gαo subunit of heterotrimeric G proteins, in four individuals with epileptic encephalopathy...
  3. doi Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits
    Ricardo Mostany
    Departamento de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Cantabria, Av Herrera Oria s n, E 39011 Santander, Spain
    Neuropharmacology 54:989-97. 2008
    ..35S]GTP gamma S binding, mu-agonist-induced adenylyl cyclase inhibition, and co-precipitation of G alpha o, G alpha i2 G alpha z and G alpha q11 subunits with mu-opioid receptors...
  4. ncbi Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA 92697 1675, USA
    Schizophr Res 67:41-52. 2004
    ..3-q32) and the human guanine nucleotide-binding regulatory protein Go-alpha (GNAO1 localized at 16q13) was significantly decreased in individuals with schizophrenia compared to unaffected family ..
  5. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
    ..a sensory neuron subfamily characterized by the expression of the G-protein Galpha(o) subunit (also known as Gnao) and Vmn2r putative pheromone receptors (V2Rs)...
  6. ncbi Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats
    Younghwa Kim
    Department of Anatomy, College of Medicine, Ewha Womans University, Seoul 158 710, Korea
    Neurochem Res 27:527-33. 2002
    ..showed that the level of G alpha s mRNA was increased in the septum and brainstem, and the level of G alpha o mRNA was elevated in the cortex during the pentobarbital withdrawal...
  7. doi Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein
    Ming Zhu
    Division of Cardiology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Am J Physiol Heart Circ Physiol 294:H1335-47. 2008
    ..To investigate the role of G alpha o in the heart, we generated transgenic mice with cardiac-specific expression of a constitutively active form of G ..
  8. ncbi RGS8 accelerates G-protein-mediated modulation of K+ currents
    O Saitoh
    Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Nature 390:525-9. 1997
    ..This property of RGS8 may be crucial for the rapid regulation of neuronal excitability upon stimulation of G-protein-coupled receptors...
  9. ncbi Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain
    K P Lesch
    Section of Neuropharmacology, National Institute of Mental Health, Bethesda, Maryland
    Biol Psychiatry 32:549-79. 1992
    ..long-term administration of a wide spectrum of antidepressant drugs regulate G alpha s, G alpha i1, G alpha i2, G alpha o, G alpha q, and G alpha 12 mRNA and protein expression in various areas of the rat brain...
  10. ncbi G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells
    Liquan Huang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 455:1-10. 2003
    ..Gbeta1, 2, and 5 are expressed in partially overlapping subpopulations of cone bipolar cells. Ggamma13 and Gbeta3 and/or Gbeta4, thus, seem selectively to participate in signal transduction by ON bipolar cells...
  11. ncbi Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel
    Ying Zhao
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    J Biol Chem 283:5306-16. 2008
    ..antisera raised against alpha and beta subunits (anti-G alpha common, anti-G beta, anti-G alpha i1/2/3, and anti-G alpha o) were used. Anti-G alpha common totally blocked the effects of NE on membrane potential and K ATP channels...
  12. pmc Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones
    M P Caulfield
    Wellcome Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London
    J Physiol 477:415-22. 1994
    ..2. Antibodies specific for G alpha q/11, but not those for G alpha o, reduced M-current inhibition by the muscarinic agonist oxotremorine-M, whereas anti-G alpha o antibodies, but ..
  13. doi Involvement of cholesterol in synaptic vesicle swelling
    Jin Sook Lee
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Biol Med (Maywood) 235:470-7. 2010
    ..Our study further demonstrates that this effect of cholesterol is due, in part, to its involvement in the interactions between AQP-6, vH(+)-ATPase and the GTP-binding G(alpha o) protein at the synaptic vesicle membrane...
  14. ncbi G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gating
    A Terzic
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905
    Neuron 12:885-93. 1994
    ..Active forms of exogenous G protein subunits (G alpha i-1, G alpha i-2, or G alpha o) activated only KATP channels closed by ATPi...
  15. ncbi Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII
    J Dedrick Jordan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:11413-21. 2005
    ..Thus, the G(alpha)o/i-coupled cannabinoid receptor, by regulating the proteasomal degradation of Rap1GAPII, activates Rap1 to induce neurite outgrowth...
  16. ncbi Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o
    J C Lang
    Abt Neuropharmakologie, Max Planck Institut fur Psychiatrie, Martinsried, FRG
    J Recept Res 9:313-29. 1989
    ..i2 was investigated in plasma membranes from different tissues and cells and compared to the distribution of G alpha o and other pertussis toxin sensitive G alpha...
  17. doi Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
    Neuroscience 162:1255-64. 2009
    ..The most salient candidate gene within this QTL, Gnao1 (guanine nucleotide binding protein, alpha(o); G alpha(o); 96...
  18. ncbi Developmental expression of G alpha o and G alpha s isoforms in PC12 cells: relationship to neurite outgrowth
    S Andreopoulos
    Section of Biochemical Psychiatry, Clarke Institute of Psychiatry, University of Toronto, Ont, Canada
    Brain Res Dev Brain Res 88:30-6. 1995
    ..Furthermore, no significant changes were observed in the levels of alpha o or alpha s isoforms following NGF removal. These findings suggest that alpha o isoforms are involved in neuritic extension in PC12 cells...
  19. pmc Isolation and expression of a novel chick G-protein cDNA coding for a G alpha i3 protein with a G alpha 0 N-terminus
    E J Kilbourne
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Biochem J 297:303-8. 1994
    ..sequence in which the first 45 amino acids coded for are 100% identical to the conserved N-terminus of G alpha o from species such as rat, mouse, human, bovine and hamster...
  20. ncbi Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists
    J Gomeza
    UPR Centre Nationale de Recherche Scientifique 9023, Mecanismes Moleculaires des Communications Cellulaires, CCIPE, Montpeller, France
    Mol Pharmacol 50:923-30. 1996
    ..Furthermore, the exchange of a few carboxyl-terminal residues of G alpha q by those of G alpha 12 or G alpha o allows the resulting chimeric G alpha subunits (G alpha ql and G alpha qol respectively) to couple Gi-coupled ..
  21. pmc Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3
    W van't Hof
    Cell Biology and Genetics Program, Sloan Kettering Institute for Cancer Research, New York, NY 10021, USA
    J Cell Biol 136:1023-35. 1997
    ..These results serve to define a novel trafficking pathway for Src family proteins that are regulated by dual fatty acylation...
  22. ncbi Serotonin-mediated palmitoylation and depalmitoylation of G alpha proteins in rat brain cortical membranes
    S Bhamre
    Laboratory of Molecular Pharmacology, Department of Pharmacology, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 286:1482-9. 1998
    ....
  23. ncbi Reductions in binding and functions of D2 dopamine receptors in the rat ventral striatum during amphetamine sensitization
    J C Chen
    Department of Pharmacology, Chang Gung University, Tao Yuan, Taiwan, ROC
    Life Sci 64:343-54. 1999
    ..The decreases in D2 receptor function were unrelated to the coupled G-proteins, since none of the G alpha i-3, G alpha o or G alpha q in the ventral striatum exhibited quantitative differences between control and amphetamine ..
  24. ncbi Modest cholinergic deafferentation fails to alter hippocampal G-proteins
    M McLaughlin
    Neuroscience Institute, Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, UK
    Neurochem Int 35:59-64. 1999
    ....
  25. ncbi Involvement of G(q/11) in signal transduction in the mammalian vomeronasal organ
    Kennedy S Wekesa
    Alabama State University, Biomedical Research and Training Programs, Montgomery, AL 36104 0271, USA
    J Exp Biol 206:827-32. 2003
    ..Our observations indicate that pheromones in male urine act on vomeronasal neurons in the female VNO via a receptor-mediated, G alpha(q/11)-protein-dependent increase in IP(3) levels...
  26. ncbi A retinal-specific regulator of G-protein signaling interacts with Galpha(o) and accelerates an expressed metabotropic glutamate receptor 6 cascade
    Anuradha Dhingra
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058, USA
    J Neurosci 24:5684-93. 2004
    ..This would tend to match its kinetics to that of the OFF bipolar that arises directly from ligand-gated channels...
  27. ncbi Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptor
    Heng Xu
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224 2735, USA
    J Pharmacol Exp Ther 315:248-55. 2005
    ..chronic morphine treatment decreased the expression of G alpha i2 (64%) and G alpha i3 (60%), had no effect of G alpha o, and increased G alpha12 (66%) expression in Chinese hamster ovary (CHO) cells expressing the cloned human mu ..
  28. ncbi The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3
    John Cijiang He
    Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:33426-34. 2005
    ..Overall, this study demonstrated that G alpha(o/i)-coupled CB1R triggers neurite outgrowth in Neuro-2A through the activation of a signaling network containing two pathways that bifurcate at Src and converge at Stat3...
  29. ncbi GPCR signaling is required for blood-brain barrier formation in drosophila
    Tina Schwabe
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, NY 10021, USA
    Cell 123:133-44. 2005
    ..Here, we show that the G protein-coupled receptor (GPCR) Moody, the G protein subunits G alpha i and G alpha o, and the regulator of G protein signaling Loco are required in the surface glia to achieve effective insulation...
  30. pmc Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
    Muriel Nobles
    British Heart Foundation Laboratories and Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Proc Natl Acad Sci U S A 102:18706-11. 2005
    ..Our work suggests that GPCR dimers and the G protein heterotrimer are present at the cell membrane in the resting state in a pentameric complex...
  31. ncbi Expression of a vomeronasal receptor gene (V1r) and G protein alpha subunits in goat, Capra hircus, olfactory receptor neurons
    Yoshihiro Wakabayashi
    Laboratory of Cell Biology and Anatomy, Department of Neuroscience Basic Technology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    J Comp Neurol 503:371-80. 2007
    ..by ORNs, whereas two vomeronasal receptor families (V1rs and V2rs) coupled respectively to G alpha i2 and G alpha o, are expressed by VRNs. Previously, we reported that one goat V1rs (gV1ra1) is expressed by ORNs and VRNs...
  32. doi G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells
    Rama Kamesh Bikkavilli
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 121:234-45. 2008
    ..The canonical WNT-beta-catenin signaling pathway requires both G alpha o and G alpha q heterotrimeric G-proteins, whereas we show that WNT-JNK signaling requires only G alpha o protein...
  33. pmc Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ
    Stephen D Liberles
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:9842-7. 2009
    ..Given the presence of formylated peptides in bacteria and mitochondria, possible roles for VNO FPRs include the assessment of conspecifics or other species based on variations in normal bacterial flora or mitochondrial proteins...
  34. doi The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway
    Diane Egger-Adam
    Department of Biology, University of Konstanz, Konstanz, Germany
    Dev Dyn 239:168-83. 2010
    ..b>G alpha o physically binds Axin and re-localizes it to the plasma membrane...
  35. pmc Gαo potentiates estrogen receptor α activity via the ERK signaling pathway
    Melyssa R Bratton
    Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL 78, New Orleans, Louisiana 70112, USA
    J Endocrinol 214:45-54. 2012
    ..In summary, our results show that Gα(o), through activation of the MAPK pathway, plays a role in the regulation of ERα activity...
  36. pmc Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors
    Mary E Hamby
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 32:14489-510. 2012
    ..involved in calcium signaling were significantly regulated, mostly down (for example, Cxcr4, Adra2a, Ednra, P2ry1, Gnao1, Gng7), but some up (for example, P2ry14, P2ry6, Ccrl2, Gnb4)...
  37. doi Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis
    Zhen Liu
    Department of Digestive Diseases, Southeast Hospital, Xiamen University, Zhangzhou, Fujian, P R China
    Int J Mol Med 33:589-96. 2014
    Guanine nucleotide-binding protein (G protein), alpha activating activity polypeptide O (GNAO1) encodes an alpha subunit of the heterotrimeric guanine nucleotide-binding proteins (Gαo), which plays a significant role in the development ..
  38. pmc Simultaneous deletion of floxed genes mediated by CaMKIIα-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goα
    Chan Il Choi
    1 Departments of Anatomy, Ajou University, School of Medicine, Suwon, South Korea 2 Neuroscience Graduate Program, Ajou University, School of Medicine, Suwon, South Korea 3 BK21 Division of Cell Transformation and Restoration, Ajou University, School of Medicine, Suwon, South Korea
    Exp Mol Med 46:e93. 2014
    ..Similarly, when double transgenic Gnao(+/f)::CaMKIIα-Cre(+/Cre) mice carrying a floxed Go-alpha gene (Gnao(f/f)) were backcrossed to wild-type females, ..
  39. pmc Harnessing gene expression networks to prioritize candidate epileptic encephalopathy genes
    Karen L Oliver
    Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia Epilepsy Research Center, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    PLoS ONE 9:e102079. 2014
    ..the nineteen genes that we predicted with the highest likelihood to be true Epileptic Encephalopathy genes, two (GNAO1 and GRIN2B) have recently been independently reported and confirmed...
  40. pmc Phenotypic spectrum of GNAO1 variants: epileptic encephalopathy to involuntary movements with severe developmental delay
    Hirotomo Saitsu
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Eur J Hum Genet 24:129-34. 2016
    De novo GNAO1 variants have been found in four patients including three patients with Ohtahara syndrome and one patient with childhood epilepsy...
  41. pmc Identification of a Novel Gnao-Mediated Alternate Olfactory Signaling Pathway in Murine OSNs
    Paul Scholz
    Department of Cell Physiology, Ruhr University Bochum Bochum, Germany
    Front Cell Neurosci 10:63. 2016
    ..Interestingly, this pathway is mediated by Gnao activation, leading to Cl(-) efflux; however, the activation of adenylyl cyclase III (ACIII), the recruitment of Ca(..
  42. pmc A central role for R7bp in the regulation of itch sensation
    Mritunjay Pandey
    1Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 2North Carolina State University, College of Veterinary Medicine, Department of Molecular Biomedical Sciences, Raleigh, NC 3Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 4Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 5Molecular Genetics Unit, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
    Pain . 2017
    ..Knock-in to mice of a GTPase activating protein-insensitive mutant of Gαo (Gnao1 G184S/+) produces a similar pruriceptive phenotype...
  43. ncbi Molecular cloning and sequence determination of four different cDNA species coding for alpha-subunits of G proteins from Xenopus laevis oocytes
    J Olate
    Departamento de Bioquimica, Facultad de Medicina, Universidad de Chile, Santiago
    FEBS Lett 268:27-31. 1990
    ..In addition to a clone coding for a G alpha o-type subunit previously reported [(1989) FEBS Lett...
  44. ncbi A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits
    J Chen
    Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, NY 10029, USA
    Science 268:1166-9. 1995
    ..of calmodulin-stimulated adenylyl cyclases, but had no effect on interactions between G beta gamma and G alpha o. Substitutions in this peptide identified a functionally important motif, Gln-X-X-Glu-Arg, that is also ..
  45. ncbi Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension
    A Petit
    Department of Obstetrics and Gynecology, University of Montreal, Research Center, Ste Justine Hospital, Quebec, Canada
    Life Sci 60:953-60. 1997
    ..Specifically, G alpha i2, G alpha i3, G alpha o, G alpha s, and G alpha q/11 levels reached 87%, 81%, 91%, 99%, and 103% respectively of those from normal ..
  46. ncbi G-protein expression in melanotropes changes coincident with innervation of the developing rat pituitary intermediate lobe
    S A Sands
    School of Biological Sciences, University of Missouri Kansas City 64108, USA
    Int J Dev Neurosci 15:329-41. 1997
    ..Using immunohistochemistry, this study examined expression of G alpha i1/2, G alpha i3, G alpha o and G alpha s proteins before and after dopaminergic innervation...
  47. ncbi Activation and inhibition of G proteins by lipoamines
    Evelyn Breitweg-Lehmann
    Institute of Pharmacology, Berlin Free University, Berlin, Germany
    Mol Pharmacol 61:628-36. 2002
    ..In the presence of G beta gamma, they rather antagonize G protein-coupled receptor signaling...
  48. ncbi M1 muscarinic receptor signaling in mouse hippocampus and cortex
    Amy C Porter
    Lilly Research Laboratories, Neuroscience Research Division, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Brain Res 944:82-9. 2002
    ..These findings support a role for the M1 receptor subtype as the primary G(alpha)(q)/11-coupled muscarinic receptor in mouse hippocampus and cortex...
  49. ncbi Selective G protein beta gamma-subunit compositions mediate phospholipase C activation in the vomeronasal organ
    Karin Rünnenburger
    Department of Pharmacology and Toxicology, University of Ulm, Germany
    Eur J Cell Biol 81:539-47. 2002
    ....
  50. ncbi Mechanism of action of Gq to inhibit G beta gamma modulation of CaV2.2 calcium channels: probed by the use of receptor-G alpha tandems
    Federica Bertaso
    Department of Pharmacology, University College London, London, United Kingdom
    Mol Pharmacol 63:832-43. 2003
    ..The potential sites of phosphorylation are discussed...
  51. ncbi Vomeronasal phenotype and behavioral alterations in G alpha i2 mutant mice
    E Marianne Norlin
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Curr Biol 13:1214-9. 2003
    ..The significance of this dichotomy is largely unknown. VN neurons express high levels of either G alpha i2 or G alpha o. A mouse line carrying a targeted disruption of the G alpha i2 gene offered the opportunity for studying the ..
  52. ncbi Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping
    Joseph A Cioffi
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Acta Otolaryngol 123:1027-34. 2003
    ..The purpose of this study was to better define the role of these proteins by examining their expression in the rat vestibular periphery and characterizing their chromosomal location...
  53. ncbi Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegans
    Satoshi Suo
    Department of Psychiatry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 26:10082-90. 2006
    ..The results show that the endogenous octopamine system in C. elegans is activated by starvation and that different environmental stimuli can activate CREB through G alpha(q)...
  54. doi 17beta-Oestradiol stimulation of G-proteins in aged and Alzheimer's human brain: comparison with phytoestrogens
    V Jefremov
    Department of Biochemistry, Tartu University, Tartu, Estonia
    J Neuroendocrinol 20:587-96. 2008
    ..Both of these mechanisms could be involved in the neuroprotective signalling of oestrogens that contributes to their preventive/therapeutic action against postmenopausal neurological disorders...
  55. doi Localization of G protein alpha subunits and morphology of receptor neurons in olfactory and vomeronasal epithelia in Reeve's turtle, Geoclemys reevesii
    Yoshihiro Wakabayashi
    Laboratory of Cell Biology and Anatomy, Department of Neuroscience Basic Technology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Zoolog Sci 25:178-87. 2008
    ..In rodents, signal transduction pathways involve G alpha olf and G alpha i2/G alpha o in OE and VNE, respectively. Reeve's turtles (Geoclemys reevesii) live in a semiaquatic environment...
  56. pmc Novel peptide ligands of RGS4 from a focused one-bead, one-compound library
    Rebecca A Roof
    Department of Pharmacology, University of Michigan, 1301 MSRB III SPC5632, Ann Arbor, MI 48103, USA
    Chem Biol Drug Des 72:111-9. 2008
    ..Peptide 2 has been modeled to fit in the same binding pocket predicted for YJ34 but in the reverse orientation...
  57. doi RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11
    Yasar Saleem
    Center for Neural Science, Korea Institute of Science and Technology KIST, P O BOX 131, Cheongryang, Seoul 130 650, Republic of Korea
    Biochem Biophys Res Commun 386:65-70. 2009
    ..In addition, we identified a novel interaction between Galpha(oa) and R7BP with a K(D) of 592 (+/- 150) nM. The production of stable and functional rRGS11 would provide chances to discover more functions of RGS11 yet to be identified...
  58. doi Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mol Pharmacol 76:992-7. 2009
    ..Most importantly, our results indicate a switch in G-protein coupling, in which E775K loses G(o) coupling but retains coupling to G(i), which may explain the phenotype...
  59. pmc PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology
    Kelly L McCoy
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Pharmacol 77:1005-15. 2010
    ..These studies demonstrate that PAR1 and PAR2 physically and functionally link to overlapping and distinct profiles of G proteins to differentially regulate downstream signaling pathways and cell physiology...
  60. doi Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    J Hum Genet 56:478-83. 2011
    ..In this study, we measured the mRNA expression levels of dysbindin-1, NRG-1 and two other genes (NPY1R and GNAO1) in immortalized lymphocytes from 45 patients with schizophrenia and 45 controls using real-time quantitative ..
  61. pmc Predicting the diagnosis of autism spectrum disorder using gene pathway analysis
    E Skafidas
    Centre for Neural Engineering, The University of Melbourne, Parkville, Vic, Australia
    Mol Psychiatry 19:504-10. 2014
    ..4%) in a genetically dissimilar Han Chinese cohort (HAN). Eight SNPs in three genes (KCNMB4, GNAO1, GRM5) had the largest effect in the classifier with some acting as vulnerability SNPs, whereas others were ..
  62. pmc Intra-familial tests of association between familial idiopathic scoliosis and linked regions on 9q31.3-q34.3 and 16p12.3-q22.2
    Nancy H Miller
    Department of Orthopaedic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Hum Hered 74:36-44. 2012
    ....
  63. pmc Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma
    P N Valdmanis
    1 Department of Pediatrics, Stanford University, Stanford, CA, USA 2 Department of Genetics, Stanford University, Stanford, CA, USA
    Oncogene 34:94-103. 2015
    ..This includes the repression of a network of GTPase-related genes (Prkg1, Gnao1 and Rgs9) in tumor samples and an enrichment of Apobec1-mediated cytosine to uridine RNA editing...
  64. doi Alternative splicing regulation of APP exon 7 by RBFox proteins
    Shafiul Alam
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan Electronic address
    Neurochem Int 78:7-17. 2014
    ..precursor protein (APP), disks large homolog 3 (DLG3), and G protein, alpha activating activity polypeptide O (GNAO1), was altered by transient RBFox1 expression in HEK293 and HeLa cells...
  65. pmc Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach
    Klemen Zupancic
    Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia
    Radiol Oncol 48:257-66. 2014
    ..The aim of this study was to define the impact of GBM in terms of alterations of the plasma protein levels in these patients...
  66. pmc Innate Predator Odor Aversion Driven by Parallel Olfactory Subsystems that Converge in the Ventromedial Hypothalamus
    Anabel Pérez-Gómez
    Department of Physiology and Center for Integrative Physiology and Molecular Medicine, University of Saarland School of Medicine, 66421 Homburg, Germany
    Curr Biol 25:1340-6. 2015
    ..responses in specific subsystems through disruption of genes encoding key sensory transduction proteins (Cnga3, Gnao1) or by surgical axotomy abolished avoidance behaviors and/or cellular Ca(2+) responses to different predator odors...
  67. pmc Ophthalmic Alterations in the Sturge-Weber Syndrome, Klippel-Trenaunay Syndrome, and the Phakomatosis Pigmentovascularis: An Independent Group of Conditions?
    Solmaz Abdolrahimzadeh
    Ophthalmology Unit, DAI Head Neck, Umberto I Policlinic, University of Rome Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    Biomed Res Int 2015:786519. 2015
    ..circulation, neural crest alterations leading to alterations of autonomic perivascular nerves, mutation of the GNAO gene in the Sturge-Weber syndrome, PIK3CA mutation in malformative/overgrowth syndromes such as the Klippel-..
  68. doi Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy
    Chun Yiu Law
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Clin Chim Acta 451:292-6. 2015
    ..The cause of infantile-onset epilepsy is complex and is not easily recognized clinically, particularly in paediatric patients who present with non-specific neurological signs, no radiological abnormalities and no metabolic changes...
  69. doi Clinical Course of Six Children With GNAO1 Mutations Causing a Severe and Distinctive Movement Disorder
    Amitha L Ananth
    Department of Pediatrics, Stanford University, Stanford, California Electronic address
    Pediatr Neurol 59:81-4. 2016
    Mutations in GNAO1 have been described in 11 patients to date. Although most of these individuals had epileptic encephalopathy, four patients had a severe movement disorder as the prominent feature...
  70. doi Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cells
    Meiling Jin
    Center for Diabetes, Obesity and Metabolism, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, Guangdong Province 518060, China
    Integr Biol (Camb) 8:968-75. 2016
    ..Taken together, the data presented here suggest that TLR2 activation in human mast cells promotes the release of inflammatory mediators via distinct signaling pathways that partially depend on the action of Go proteins. ..
  71. ncbi Recurrent GNAO1 Mutations Associated With Developmental Delay and a Movement Disorder
    Leonie A Menke
    Department of Pediatrics, Academic Medical Center, Amsterdam, The Netherlands
    J Child Neurol 31:1598-1601. 2016
    ..developmental delay and a hyperkinetic movement disorder, a missense mutation was found in codon 209 of the GNAO1 gene. From the still scarce literature on GNAO1 mutations, a clear genotype-phenotype correlation emerged...
  72. doi A case of severe movement disorder with GNAO1 mutation responsive to topiramate
    Saori Sakamoto
    Department of Pediatrics, Jichi Medical University, Tochigi, Japan
    Brain Dev . 2016
    We report the case of a 19-year-old female patient who had progressive chorea associated with a GNAO1 mutation...
  73. pmc Functional coupling of the human dopamine D2 receptor with G alpha i1, G alpha i2, G alpha i3 and G alpha o G proteins: evidence for agonist regulation of G protein selectivity
    Lucien Gazi
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, RG6 6AJ
    Br J Pharmacol 138:775-86. 2003
    ..5) We conclude that the degree of selectivity of G protein activation by the D(2L) receptor can depend on the conformation of the receptor stabilised by an agonist...
  74. ncbi Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling
    Britta Settmacher
    Department of Medical Microbiology, Medical School Hannover, Hannover, Germany
    Eur J Immunol 33:920-7. 2003
    ....
  75. ncbi Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
    D Turic
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 127:68-72. 2004
    ..All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD...
  76. pmc Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans
    Paloma Alonso-Magdalena
    Institute of Bioengineering, Miguel Hernandez University, Sant Joan d Alacant, Alicante, Spain
    Environ Health Perspect 113:969-77. 2005
    ..The effects triggered by BPA, DES, and E2 are blocked by the G alpha i- and G alpha o-protein inhibitor pertussis toxin, by the guanylate cyclase-specific inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]..
  77. ncbi Role of G proteins and ERK activation in hemin-induced erythroid differentiation of K562 cells
    Bahire Kucukkaya
    Marmara University School of Medicine, Department of Biophysics, Tibbiye Caddesi No 49, Haydarpasa, 34668, Istanbul, Turkey
    Life Sci 78:1217-24. 2006
    ..Our results suggest that changes in G protein expression and ERK2 activity are involved in hemin-induced differentiation of K562 cells...
  78. doi New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics
    Arulmani Manavalan
    School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Proteomics 75:2468-79. 2012
    ..the brain protein metabolism at the proteome level by down-regulating the expressions of various proteins, such as Gnao1 and Dctn2, which are related to neuronal growth cone control and synaptic activities...
  79. pmc Pathways involved in sasang constitution from genome-wide analysis in a Korean population
    Bu Yeo Kim
    Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
    J Altern Complement Med 18:1070-80. 2012
    ..However, to understand the biologic mechanisms underlying constitution, a comprehensive approach that combines individual genetic effects was applied...
  80. ncbi Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
    G Berstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
    Cell 70:411-8. 1992
    ..Such GAP activity by an effector coupled to a trimeric G protein can reconcile slow GTP hydrolysis by pure G proteins in vitro with fast physiologic deactivation of G protein-mediated signaling...
  81. ncbi Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions
    B M Denker
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    J Biol Chem 267:6272-7. 1992
    ..Deletion of this region diminishes the ability of alpha o to interact with the beta gamma subunit, but substitutions at this position indicate that other amino acids can be tolerated without affecting subunit interaction...
  82. ncbi Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor
    M Cormont
    Unit 145, National Institute of Health and Medical Research, Faculty of Medicine, Nice, France
    Diabetes 40:1170-6. 1991
    ..at concentrations where there were no effects of other antibodies specifically directed against Gi alpha 3 or G alpha o. These data suggest that Gi1 and/or Gi2 interact with the galanin receptor and probably mediate the effects of ..
  83. ncbi Ultrastructural localization of the GTP-binding protein Go in neurons
    J Gabrion
    Laboratoire de Neurobiologie Endocrinologique, UA 1197 CNRS, Universite de Montpellier II, France
    Cell Signal 1:107-23. 1989
    ....
  84. ncbi Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha
    S Lavu
    Biological Response Modifiers Program, National Cancer Institute Frederick Cancer Research Facility, MD 21701
    Biochem Biophys Res Commun 150:811-5. 1988
    ..There is 100% identity at the amino acid level for the cholera and pertussis toxin-catalyzed ADP ribosylation sites, the putative guanine nucleotide binding, and the GTP hydrolysis sites...
  85. ncbi Voltage-dependent calcium channel beta-subunits in combination with alpha 1 subunits, have a GTPase activating effect to promote the hydrolysis of GTP by G alpha o in rat frontal cortex
    V Campbell
    Department of Pharmacology, Royal Free Hospital School of Medicine, London, UK
    FEBS Lett 370:135-40. 1995
    ..This may be a mechanism by which calcium channels can normally act to limit the duration of a G-protein modulatory signal...
  86. ncbi Expression of GTP-binding protein alpha subunits in human thymocytes
    P S Kabouridis
    Department of Biology, San Diego State University, CA 92182, USA
    Mol Cell Biochem 144:45-51. 1995
    ..The alpha subunit genes identified are: G alpha i1-3 and G alpha z but not G alpha o from the Gi family, G alpha s from the Gs family, G alpha 11, G alpha q, and G alpha 16 from the Gq family, and ..
  87. ncbi Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis
    H C Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Lab Invest 71:175-81. 1994
    ..In the present study, we have conducted experiments to examine whether the G alpha subunit is also associated with mitotic spindles...
  88. ncbi Identification of GTP-binding proteins in human glomeruli
    K Nitta
    Department of Medicine, Kidney Center, Tokyo Women s Medical College, Japan
    Nihon Jinzo Gakkai Shi 36:9-12. 1994
    ..This is the first report that characterizes G-protein subunits in human glomeruli. Further study is required to determine the roles of G-proteins in signal transductions in human glomeruli...
  89. ncbi In situ hybridization reveals specific increases in G alpha s and G alpha o mRNA in discrete brain regions of morphine-tolerant rats
    D Parolaro
    Institute of Pharmacology, Faculty of Sciences, University of Milan, Italy
    Eur J Pharmacol 244:211-22. 1993
    ..significantly increased alpha s amounts in the hypothalamus (70%), and produced a minor elevation (30%) in G alpha o levels in the olfactory area...
  90. ncbi The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2
    M A Wall
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Cell 83:1047-58. 1995
    ..Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade...
  91. ncbi Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach
    L Rambhatla
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Reprod Dev 41:314-24. 1995
    ..we analyzed the patterns of expression of nine G protein alpha subunit mRNAs (G alpha s, G alpha i, G alpha q, G alpha o, and G alpha 11-15) in oocytes, eggs, and preimplantation embryos from fertilization to the blastocyst stage...
  92. ncbi Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells: activation of a G(alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2B
    L A Obosi
    School of Biological and Molecular Sciences, Oxford Brookes University, UK
    FEBS Lett 381:233-6. 1996
    ..Immunoblot analysis of the endogenous G-proteins revealed that Sf9 cells lack the G-protein subtypes G(alpha i 1-3) and G(alpha)o, but express the subtype G(alpha)s and G(alpha)q...
  93. ncbi Effect of thyroid deficiency on Go alpha-subunit isoforms in developing rat cerebral cortex
    P P Li
    Section of Biochemical Psychiatry, Clarke Institute of Psychiatry, University of Toronto, Ontario, Canada
    Neurochem Res 20:1249-55. 1995
    Postnatal development of G alpha o isoforms in rat cerebral cortex was studied by SDS-PAGE and immunoblotting...
  94. ncbi Evidence for the coupling of Gq protein to D1-like dopamine sites in rat striatum: possible role in dopamine-mediated inositol phosphate formation
    H Y Wang
    Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129, USA
    Mol Pharmacol 48:988-94. 1995
    ..Furthermore, antisera directed against G alpha s or G alpha q but not G alpha i, G alpha o, or G alpha z precipitated specific D1-like binding sites labeled with [3H]SCH23390...
  95. ncbi Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasms
    N Kawano
    Department of Pathology, Yokohama City University School of Medicine, Japan
    Pathol Int 46:393-8. 1996
    ..The biological significance of Go alpha is unclear in normal and neoplastic lung tissues, but Go alpha is a useful marker of neuroendocrine cells and neoplasma of the lung...
  96. pmc Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association
    A Wolven
    Program in Molecular Biology, Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Mol Biol Cell 8:1159-73. 1997
    ..Substitution of the SH4 motif within Fyn with heterologous sequences from other palmitoylated proteins (G alpha o and GAP43) revealed that the presence of palmitate is sufficient to direct plasma membrane localization ..
  97. ncbi A multigene family encoding a diverse array of putative pheromone receptors in mammals
    H Matsunami
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:775-84. 1997
    ..However, a dramatically different structure for VRs and the existence of variant VR mRNA forms indicate that there are diverse strategies to detect functionally distinct sensory stimuli...
  98. pmc Analysis of the N-terminal binding domain of Go alpha
    L Busconi
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem J 328:23-31. 1997
    ..A detailed understanding of G alpha-membrane interactions may reveal unique mechanisms for regulating signal transduction...
  99. ncbi Reduced adenosine A1 receptor and G alpha protein coupling in rat ventricular myocardium during aging
    G Cai
    Department of Pharmacology, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USA
    Circ Res 81:1065-71. 1997
    ..ventricular membranes, specific [3H]DPCPX binding sites were detected in immunoprecipitates of G alpha i3 and G alpha o antisera but not with antibodies for other G alpha proteins...
  100. ncbi Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane
    K M Druey
    Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    J Biol Chem 273:18405-10. 1998
    ....
  101. ncbi Activation of Go-proteins by membrane depolarization traced by in situ photoaffinity labeling of galphao-proteins with [alpha32P]GTP-azidoanilide
    Y Anis
    Department of Physiology and The Cardiac Research Institute, Sackler School of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    J Biol Chem 274:7431-40. 1999
    ..These findings support a possible involvement of VGSC in depolarization-induced activation of Go-proteins...

Research Grants7

  1. EXTRAMURAL RESEARCH FACILITIEIS CONSTRUCTION
    John Raymond; Fiscal Year: 2002
    ..Total project cost is $4,212,617, of which the University's share is 53 percent. ..
  2. NADPH OXIDASE & MESANGIAL CELL PROLIFERATION & FIBROSIS
    John Raymond; Fiscal Year: 2003
    ..Number 2. To establish a role for ROS generated by NAD(P)H oxidase in an animal model of proliferative and fibrotic renal disease. ..
  3. EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION
    John Raymond; Fiscal Year: 2003
    ..The total project cost is $6,342,887; the University is contributing $3,171,443 (50 percent). ..
  4. Human Subjects Research Enhancements Program at MUSC
    John Raymond; Fiscal Year: 2003
    ..abstract_text> ..
  5. Regulation of EGF Receptors by G protein receptor
    John Raymond; Fiscal Year: 2004
    ..These studies address important gaps in our knowledge of GPCR signals that regulate the functions of RTK's. ..
  6. Biomarker Genes in Mood Disorder: Lymphocyte and Brain
    MARQUIS VAWTER; Fiscal Year: 2006
    ..The potential use of biomarkers in lymphocytes will provide clinical researchers a tool to better address questions concerning diagnostic subgroups and treatment responders and non-responders. ..
  7. Mechanisms of Regulation Of NHE-1
    John Raymond; Fiscal Year: 2007
    ..This proposal could also lay the foundation for future structural experiments utilizing NMR and/or crystallography methods. ..