glutamyl transpeptidase

Summary

Gene Symbol: glutamyl transpeptidase
Description: gamma-glutamyltransferase 1
Alias: CD224, D22S672, D22S732, GGT, GGT 1, GTG, gamma-glutamyltranspeptidase 1, glutathione hydrolase 1, leukotriene-C4 hydrolase, testicular tissue protein Li 73
Species: human

Top Publications

  1. ncbi [Gamma glutamyl transpeptidase (gammaGTP) in the era of metabolic syndrome]
    Hirokazu Yokoyama
    Health Center, Keio University, 35 Shinanomachi, Shinjyuku ku, Tokyo 160 8582, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 42:110-24. 2007
  2. pmc Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis
    Brenda Diergaarde
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Pancreatology 10:194-200. 2010
  3. ncbi Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes
    T C Nichols
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Eur J Immunol 28:4123-9. 1998
  4. pmc Metabolic syndrome is directly associated with gamma glutamyl transpeptidase elevation in Japanese women
    Hiroshi Sakugawa
    First Department of Internal Medicine, University Hospital, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903 0125, Japan
    World J Gastroenterol 10:1052-5. 2004
  5. ncbi Association between serum gamma-glutamyltransferase and C-reactive protein
    Duk Hee Lee
    Department of Preventive Medicine, Division of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Daegu 700 422, Korea
    Atherosclerosis 178:327-30. 2005
  6. ncbi Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, University of Toronto, Rm G 106, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Arterioscler Thromb Vasc Biol 27:127-33. 2007
  7. ncbi Can gamma-glutamyltransferase be an additional marker of arterial stiffness?
    Sang Heon Song
    Department of Internal Medicine, Pusan National University Hospital, Ami dong, Seo Gu, Busan, Republic of Korea
    Circ J 71:1715-20. 2007
  8. doi gamma-Glutamyltransferase, obesity, physical activity, and the metabolic syndrome in indigenous Australian adults
    Ming Li
    Division of Health Sciences, University of South Australia, South Australia, Australia
    Obesity (Silver Spring) 17:809-13. 2009
  9. doi Cultured human cells release soluble gamma-glutamyltransferase complexes corresponding to the plasma b-GGT
    Maria Franzini
    Scuola Superiore S Anna, Pisa, Italy
    Biomarkers 14:486-92. 2009
  10. doi Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals
    Chang Hee Jung
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Clin Endocrinol (Oxf) 75:328-34. 2011

Research Grants

  1. ROHIT J LOOMBA; Fiscal Year: 2014
  2. Kenneth R Johnson; Fiscal Year: 2016
  3. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2009
  4. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
  5. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
  6. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
  7. GLUTATHIONE CONJUGATION--MEDIATOR OF ORGAN TOXICITY
    Serrine Lau; Fiscal Year: 1992
  8. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
  9. METABOLIC AND MOLECULAR CONTROL OF MYELOPOIESIS
    Alan Miller; Fiscal Year: 1991
  10. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2005

Detail Information

Publications344 found, 100 shown here

  1. ncbi [Gamma glutamyl transpeptidase (gammaGTP) in the era of metabolic syndrome]
    Hirokazu Yokoyama
    Health Center, Keio University, 35 Shinanomachi, Shinjyuku ku, Tokyo 160 8582, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 42:110-24. 2007
    Current knowledge on gamma glutamyl transpeptidase (gammaGTP) was reviewed...
  2. pmc Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis
    Brenda Diergaarde
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Pancreatology 10:194-200. 2010
    ..Knowledge regarding genetic factors that influence pancreatic cancer risk is currently limited. To identify novel pancreatic cancer susceptibility loci, we conducted a two-stage genome-wide association study...
  3. ncbi Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes
    T C Nichols
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Eur J Immunol 28:4123-9. 1998
    ..One inhibitory mAb (3A8) was found to recognize the ecto-enzyme gamma-glutamyl transpeptidase (GGT), a membrane protein involved in recycling extracellular glutathione and regulating intracellular ..
  4. pmc Metabolic syndrome is directly associated with gamma glutamyl transpeptidase elevation in Japanese women
    Hiroshi Sakugawa
    First Department of Internal Medicine, University Hospital, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903 0125, Japan
    World J Gastroenterol 10:1052-5. 2004
    This study aimed to determine whether metabolic syndrome is directly or indirectly, through fatty liver, associated with elevated gamma-glutamyl transpeptidase (GGT) levels in Japanese women.
  5. ncbi Association between serum gamma-glutamyltransferase and C-reactive protein
    Duk Hee Lee
    Department of Preventive Medicine, Division of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Daegu 700 422, Korea
    Atherosclerosis 178:327-30. 2005
    A series of epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress...
  6. ncbi Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, University of Toronto, Rm G 106, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Arterioscler Thromb Vasc Biol 27:127-33. 2007
    To determine whether serum gamma-glutamyl transferase (GGT) predicts cardiovascular disease (CVD) morbidity and mortality, accounting for temporal changes in known CVD risk factors and C-reactive protein (CRP).
  7. ncbi Can gamma-glutamyltransferase be an additional marker of arterial stiffness?
    Sang Heon Song
    Department of Internal Medicine, Pusan National University Hospital, Ami dong, Seo Gu, Busan, Republic of Korea
    Circ J 71:1715-20. 2007
    It has been recently suggested that gamma-glutamyltransferase (GGT) is independently associated with cardiovascular mortality and atherosclerosis, so the present study evaluated whether GGT is an additional marker of arterial stiffness, ..
  8. doi gamma-Glutamyltransferase, obesity, physical activity, and the metabolic syndrome in indigenous Australian adults
    Ming Li
    Division of Health Sciences, University of South Australia, South Australia, Australia
    Obesity (Silver Spring) 17:809-13. 2009
    ..the association between obesity, metabolic syndrome, physical activity, and elevated gamma-glutamyltransferase (GGT) among Indigenous Australian adults who did not drink alcohol...
  9. doi Cultured human cells release soluble gamma-glutamyltransferase complexes corresponding to the plasma b-GGT
    Maria Franzini
    Scuola Superiore S Anna, Pisa, Italy
    Biomarkers 14:486-92. 2009
    Serum gamma-glutamyltransferase (GGT) is thought to derive from the liver, but its values predict morbidity and mortality for several diseases, such as cardiac infarction, stroke, diabetes, renal failure and cancer...
  10. doi Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals
    Chang Hee Jung
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Clin Endocrinol (Oxf) 75:328-34. 2011
    Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease...
  11. pmc Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations
    Rita P Middelberg
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mol Genet 21:446-55. 2012
    Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers...
  12. doi Fatty liver index, gamma-glutamyltransferase, and early carotid plaques
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hepatology 55:1406-15. 2012
    ..and FH-CVD, higher blood pressure, plasma low-density lipoprotein cholesterol, glucose, gamma-glutamyltransferase (GGT), and hsCRP, as compared to subjects without plaques (P < 0.05)...
  13. ncbi Levels of the oxidative stress marker γ-glutamyltranspeptidase at different stages of nonalcoholic fatty liver disease
    M Irie
    Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Int Med Res 40:924-33. 2012
    ..oxidative stress in the liver, by determining hepatic expression and serum levels of γ-glutamyltranspeptidase (GGT) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in different stages of nonalcoholic fatty liver disease (NAFLD), and ..
  14. doi Association of serum gamma-glutamyltransferase with arterial stiffness in established coronary artery disease
    Cansheng Zhu
    Department of Neurology, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Angiology 64:15-20. 2013
    Serum gamma-glutamyltransferase (GGT) has been reported to predict vascular risk. We enrolled 978 patients (507 men and 471 women) with established coronary artery disease (CAD)...
  15. pmc Serum γ-glutamyl transferase levels, insulin resistance and liver fibrosis in patients with chronic liver diseases
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    PLoS ONE 7:e51165. 2012
    ....
  16. doi Association of gamma-glutamyltransferase and risk of cancer incidence in men: a prospective study
    Alexander M Strasak
    Departments of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Austria
    Cancer Res 68:3970-7. 2008
    Although several epidemiologic studies have shown that gamma-glutamyltransferase (GGT) is independently associated with cardiovascular disease and all-cause mortality, its relationship with cancer incidence remains widely unexplored...
  17. ncbi Association between serum gamma-glutamyl transferase level and prehypertension among community-dwelling men
    Ryuichi Kawamoto
    Department of Internal Medicine, Nomura Municipal Hospital, Ehime, Japan
    Tohoku J Exp Med 216:213-21. 2008
    Serum gamma-glutamyl transferase (GGT) activity is a general clinical marker of excessive alcohol consumption, and GGT reflects changes in oxidative stress and implicated in the progression of hypertension...
  18. doi Gamma-glutamyltransferase and prognosis in patients with stable coronary heart disease followed over 8 years
    L P Breitling
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Center, Bergheimer Str 20, 69115 Heidelberg, Germany
    Atherosclerosis 210:649-55. 2010
    ..Serum gamma-glutamyltransferase (gamma-GT) predicts incident cardiovascular disease and mortality. The present study examined whether gamma-GT also is associated with prognosis in patients with stable coronary heart disease...
  19. doi The relationship of gamma-glutamyltransferase to aortic elastic properties in young patients with prehypertension
    Turgay Celik
    Gulhane Military Medical Academy, School of Medicine, Department of Cardiology, Etlik Ankara, Turkey
    Clin Exp Hypertens 32:377-84. 2010
    Some cross-sectional studies have demonstrated a positive association between serum gamma-glutamyltransferase (GGT) levels and blood pressure...
  20. ncbi Treatment of progressive familial intrahepatic cholestasis: liver transplantation or partial external biliary diversion
    H Ismail
    The Department of Pediatric Surgery and Organ Transplantation, The Children's Memorial Health Institute, Warsaw, Poland
    Pediatr Transplant 3:219-24. 1999
    ..In patients before established liver cirrhosis, PEBD should be the first choice of treatment. Patients presenting with cirrhosis or after ineffective PEBD should qualify for OLTx. With this strategy most children with PIFC can be cured...
  21. ncbi Experimental murine schistosomiasis: reduced hepatic morbidity after pre- and/or post-infection treatment with ibuprofen or diclofenac sodium
    M M Farag
    Department of Pharmacology, Alexandria University, Egypt
    Ann Trop Med Parasitol 89:497-504. 1995
    ..was continued after infection, for 28 days, there was an additional significant decrease in hepatic gamma-glutamyl transpeptidase activity...
  22. ncbi Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital
    H Maruyama
    American Health Foundation, Valhalla, New York 10595
    Toxicol Pathol 18:257-67. 1990
    ..DEHP increased alkaline phosphatase activity throughout the lobule, but reduced gamma-glutamyltransferase (GGT) activity in periportal hepatocytes. PB, in contrast, increased GGT activity in periportal hepatocytes...
  23. ncbi Gamma-glutamyl transferase expression in higher-grade astrocytic glioma
    C Schafer
    Department of Neurosurgery, Martin Luther University Halle Wittenberg, Germany
    Acta Oncol 40:529-35. 2001
    Increased expression of gamma-glutamyltransferase (GGT) has been detected in a range of human malignancies and is thought to be involved in neoplastic proliferation and treatment resistance...
  24. ncbi Activation of a ribosomal S6 protein kinase in rapidly emerging diethylnitrosamine-induced gamma-glutamyltranspeptidase-positive hyperplastic liver lesions of the rat
    R Comolli
    Dipartimento di Fisiologia e Biochimica Generali, , Italy
    Tumori 75:527-32. 1989
    The gamma-glutamyl transpeptidase (GGT)-positive hyperplastic liver lesions which developed in the Fisher 344 rat 7 and 60 days following a single carcinogenic dose of diethylnitrosamine (DENA, 200 mg/kg body weight), short-term dietary ..
  25. ncbi Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats
    A Hagiwara
    First Department of Pathology, Nagoya City University Medical School, Japan
    Toxicol Pathol 20:197-204. 1992
    ..NAG, and lactate dehydrogenase, LDH) and sugar levels were increased, and the brush border enzymes (gamma-glutamyl transpeptidase, GGT, and alkaline phosphatase, ALP) decreased...
  26. ncbi [Metabolism and vascular effects of gammaglutamyl L-dopa on the isolated kidney of the rat]
    A Caillette
    , , Lyon, France
    Arch Mal Coeur Vaiss 81:179-82. 1988
    ..This is the consequence of the sequential action of two renal enzymes, gamma-glutamyl transpeptidase (gamma-GT) and aromatic L-amino acid decarboxylase...
  27. ncbi Changes in vitamin E concentration after surgery and anesthesia
    J Zunic
    Department of Anesthesiology and Intensive Care, County Hospital Karlovac, Croatia
    Coll Antropol 21:327-34. 1997
    ..activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) were determined. Statistical analysis: ANOVA, Tukay HSD test...
  28. ncbi The effect of erythritol on the stability of gamma-glutamyl transpeptidase and N-acetyl glucosaminidase in human urine
    W F Loeb
    Ani Lytics Inc, Gaithersburg, Maryland 20877, USA
    Toxicol Pathol 25:264-7. 1997
    ..studies and clinical trials of erythritol, treated animals and human subjects had higher urine gamma-glutamyl transpeptidase [gamma-glutamyl transferase (gamma-GT)] than untreated controls...
  29. ncbi Fibrinolytic activity as a predictor of the outcome of prolapsed intervertebral lumbar disc surgery with reference to background variables: results of a prospective cohort study
    A K Haaland
    , Oslo, Norway
    Spine (Phila Pa 1976) 17:1022-7. 1992
    ..Background variables and lipid profile were also recorded preoperatively. Body mass index, gamma-glutamyl transpeptidase, triglycerides and smoking were of statistical significance in relation to euglobulin clot lysis time and ..
  30. ncbi Renal cell tumors induced in CBA male mice by 1,2-dimethylhydrazine
    V S Turusov
    Cancer Research Centre, Russian Academy of Medical Sciences, Moscow, Russia
    Toxicol Pathol 20:570-5. 1992
    ..Gamma-glutamyl transpeptidase (GGT) was strongly positive in normal proximal convoluted tubules, slightly positive in the cells of ..
  31. ncbi GB virus C (GBV-C) infection in patients with chronic hepatitis C. Influence on liver disease and on hepatitis virus behaviour: effect of interferon alfa therapy
    J M Pawlotsky
    Department of Bacteriology and Virology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    J Med Virol 54:26-37. 1998
    ..age, gender, source of HCV, estimated duration of HCV infection, alanine aminotransferase and gamma-glutamyl transpeptidase activities, cirrhosis and Knodell's score on liver biopsy, HCV genotype, HCV viral burden and anti-HCV ..
  32. ncbi Sequential functional and morphological alterations during hepatocarcinogenesis induced in rats by feeding of a low dose of 2-acetylaminofluorene
    F Stenback
    Department of Pathology, University of Oulu, Finland
    Toxicol Pathol 22:620-32. 1994
    ..by deficiencies in iron storage (IS-) and collagen production and by expression of gamma-glutamyl transferase (GGT+) and placental-type glutathione transferase (PGT+) activity appeared. Single PGT+ cells were also found...
  33. ncbi Enzymic pattern of preneoplastic and neoplastic lesions induced in the kidney of CBA mice by 1,2-dimethylhydrazine
    Y S Ahn
    , Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Toxicol Pathol 22:415-22. 1994
    ..malic enzyme (ME), succinate dehydrogenase (SDH), alkaline phosphatase (ALPase) and gamma-glutamyltranspeptidase (GGT). RCTs displayed the same histochemical profile irrespective of their size and growth pattern...
  34. ncbi Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury
    Noori S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    J Med Food 6:231-47. 2003
    ..v. infusion of 80 g of honey, and estimations of serum gamma-glutamyl transpeptidase (SGGT), serum glutamic oxaloacetic transaminase (SGOT), and serum glutamate pyruvate transaminase (SGPT) ..
  35. ncbi [Activity of gamma-glutamyltransferase in blood of smoking and non-smoking smelters]
    Halina Milnerowicz
    Zakład Biomedycznych Analiz Srodowiskowych, Wydział Farmaceutyczny, Akademia Medyczna, Wrocław
    Przegl Lek 67:910-3. 2010
    ..of liver damage useful are the methods which determine the activity of enzymes such as gamma-glutamyl-transferase (GGT). GGT is present in the liver and bile duct. In the serum is mainly from hepatic...
  36. ncbi Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat
    H C Pitot
    McArdle Laboratory for Cancer Research Medical School, University of Wisconsin, Madison 53706
    Toxicol Pathol 17:594-611; discussion 611-2. 1989
    ..The relative effectiveness of four different markers--gamma-glutamyltranspeptidase (GGT), a placental form of glutathione S-transferase (GST), canalicular ATPase, and glucose 6-phosphatase (G6Pase)--was ..
  37. doi Indices of urine N-acetyl-beta-D-glucosaminidase and gamma-glutamyl transpeptidase activities in clinically normal adult dogs
    Jill D Brunker
    Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Am J Vet Res 70:297-301. 2009
    To establish reference ranges for indices of urine N-acetyl-B-D-glucosaminidase (NAG) and gamma-glutamyl transpeptidase (GGT) activities in clinically normal adult dogs.
  38. doi A new splicing site mutation of the ABCB4 gene in intrahepatic cholestasis of pregnancy with raised serum gamma-GT
    D Tavian
    Laboratory of Human Molecular Biology and Genetics, Catholic University of the Sacred Heart, Milan, Italy
    Dig Liver Dis 41:671-5. 2009
    ..In a subgroup of women, the serum gamma-glutamyl transpeptidase level is also increased...
  39. pmc Pulmonary inflammation induced by a recombinant Brugia malayi gamma-glutamyl transpeptidase homolog: involvement of humoral autoimmune responses
    A S Gounni
    Meakins Christie Laboratories, McGill University, Montreal, Canada
    Mol Med 7:344-54. 2001
    ..TPE) has recently been cloned and identified as the homolog of the membrane-bound mammalian enzyme gamma-glutamyl transpeptidase (gamma-GT)...
  40. pmc Role for recombinant gamma-glutamyltransferase from Treponema denticola in glutathione metabolism
    Lianrui Chu
    Department of Orthodontics, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Infect Immun 71:335-42. 2003
    ..In this pathway, gamma-glutamyltransferase (GGT) has been proposed to catalyze the first step of glutathione degradation. We have cloned the gene of GGT from T...
  41. ncbi Effect of aurothioglucose on glutathione and glutathione-metabolizing and related enzymes in rat liver and kidney
    C J Dillard
    Department of Food Science and Technology, University of California, Davis 95616
    Chem Biol Interact 64:103-14. 1987
    ..The enzymes measured were GSH peroxidase, GSSG reductase, gamma-glutamyl transpeptidase, gamma-glutamylcysteine synthetase, GSH S-transferase, GSH thiotransferase, glucose-6-phosphate ..
  42. ncbi Influence of bromfenvinphos alone, and in mixture with methoxychlor, on levels of gamma-glutamyl transpeptidase, ceruloplasmin and cholesterol in the blood plasma of laboratory mice
    K I Zaleska-Freljan
    Department of Vertebrate Animal Physiology, University of Warsaw, Poland
    Pol J Pharmacol 45:309-16. 1993
    ..The activity of gamma-glutamyl transpeptidase (GGTP), ceruloplasmin (CRP), and cholesterol in the blood plasma were determined...
  43. ncbi Treatment with anti-gamma-glutamyl transpeptidase antibody attenuates osteolysis in collagen-induced arthritis mice
    Yasuyuki Ishizuka
    Applied Cell Biotechnologies, Yokohama, Kanagawa, Japan
    J Bone Miner Res 22:1933-42. 2007
    The effectiveness of a new antibody treatment on arthritis-associated osteolysis was studied by using CIA mice. GGT, a newly identified bone-resorbing factor, was upregulated in arthritic joints...
  44. pmc gamma-Glutamyl transpeptidase in the yeast Saccharomyces cerevisiae and its role in the vacuolar transport and metabolism of glutathione
    K Mehdi
    Universite Libre de Bruxelles, Laboratoire de Physiologie et d Ecologie Microbiennes, Institut Pasteur de Bruxelles, 642 Rue Engeland, B 1180 Brussels, Belgium
    Biochem J 359:631-7. 2001
    In the yeast Saccharomyces cerevisiae, the enzyme gamma-glutamyl transpeptidase (gamma-GT; EC 2.3.2.2) is a glycoprotein that is bound to the vacuolar membrane...
  45. ncbi [Clinical impact of gamma-glutamyl transpeptidase messenger RNA subtypes on early diagnosis of hepatocellular carcinoma]
    Guo Qing Han
    Shandong Provincial Hospital, Jinan 250021, P R China
    Ai Zheng 21:192-5. 2002
    It has been reported that hepatocellular carcinoma (HCC) expresses gamma-glutamyl transpeptidase (GGT) with unique carbohydrate moieties compared with normal liver GGT enzymes, this unique GGT was used as a marker for the diagnosis of ..
  46. ncbi Hepatic technetium-99m-mebrofenin iminodiacetate scans and serum gamma-glutamyl transpeptidase levels interpreted in series to differentiate between extrahepatic biliary atresia and neonatal hepatitis
    N K Arora
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi
    Acta Paediatr 90:975-81. 2001
    Hepatic technetium-99m-mebrofenin iminodiacetate (99mTc-mebrofenin IDA) scans and serum gamma-glutamyl transpeptidase (GGTP) have high sensitivity for extrahepatic biliary atresia (EHBA)...
  47. doi Joint effects of coffee consumption and serum gamma-glutamyltransferase on the risk of liver cancer
    Gang Hu
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Hepatology 48:129-36. 2008
    ..No prospective studies on the association between serum gamma-glutamyltransferase (GGT) and liver cancer risk have been reported...
  48. doi [The association of central obesity with type 2 diabetes among Koreans according to the serum gamma-glutamyltransferase level: Korean genome and epidemiology study]
    Ji Yeon Shin
    Department of Preventive Medicine, Kyungpook National University School of Medicine, Korea
    J Prev Med Public Health 42:386-91. 2009
    This cross-sectional study was performed to examine if the serum gamma-glutamyltransferase (GGT) level that is within its normal range is associated with the risk of type 2 diabetes and if the association between the waist hip ratio (WHR)..
  49. ncbi Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver
    M Root
    Biomar International, Inc, Chapel Hill, NC 27514, USA
    Chem Biol Interact 106:213-27. 1997
    ..Earlier work also showed that after ten daily doses the AFB dose-response relationship with gamma-glutamyl transpeptidase (GGT) positive preneoplastic foci measured at 3 months was sublinear, with a threshold at a dose of about ..
  50. ncbi Nonlinear free energy relationship in the general-acid-catalyzed acylation of rat kidney gamma-glutamyl transpeptidase by a series of gamma-glutamyl anilide substrate analogues
    A Menard
    Departement de Chimie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Biochemistry 40:12678-85. 2001
    The gamma-glutamyl transpeptidase (GGT) purified from rat kidney reacts with a series of eight parasubstituted L-glutamyl gamma-anilides, in the presence of Gly-Gly, catalyzing the formation of gamma-Glu-Gly-Gly (pH 8.0, 37 degrees C)...
  51. ncbi Serum gamma-glutamyltransferase activity is increased in patients with calcific aortic valve stenosis
    Huseyin Bozbas
    Baskent University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey
    J Heart Valve Dis 17:371-5. 2008
    A growing body of data indicates an independent association between serum gamma-glutamyltransferase (GGT) activity, a marker of increased oxidative stress, and cardiovascular diseases...
  52. ncbi The gamma-glutamyl transpeptidase inhibitor acivicin preserves glutathione released by astroglial cells in culture
    R Dringen
    Physiologisch chemisches Institut der Universität, Tubingen
    Neurochem Res 22:727-33. 1997
    ..of the glutathione concentration in the incubation medium was found if the astroglial ectoenzyme gamma-glutamyl transpeptidase was inhibited by acivicin...
  53. ncbi Structure of the 5' sequences of the human gamma-glutamyltransferase gene
    A Visvikis
    Centre du Medicament, EA 3117, Faculté de Pharmacie UHP Nancy 1, 30 rue Lionnois, 54000 Nancy, France
    Eur J Biochem 268:317-25. 2001
    In humans, five distinct mRNAs code for gamma-glutamyltransferase (GGT). Their coding regions are identical and their 5' untranslated regions exhibit both common and type-specific sequences...
  54. ncbi Slow-binding inhibition of gamma-glutamyl transpeptidase by gamma-boroGlu
    R L Stein
    Department of Chemical Enzymology, DuPont Pharmaceuticals Company, Wilmington, Delaware 19880, USA
    Biochemistry 40:5804-11. 2001
    gamma-Glutamyl transpeptidase (gammaGTase) catalyzes the transfer of the gamma-glutamyl moiety of gamma-glutamyl-derived peptides, such as glutathione (gammaGlu-Cys-Gly), and anilides, such as gamma-glutamyl-7-amido-4-methylcoumarin (..
  55. ncbi Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif
    Idun Merete Mikkelsen
    Department of Medical Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Biochem Pharmacol 64:307-15. 2002
    The single-copy gene for rat gamma-glutamyltransferase (GGT) encodes at least seven distinct mRNAs that differ in their 5'-untranslated regions only...
  56. ncbi The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased gamma-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: a prospective cohort study over
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Int J Mol Med 17:77-82. 2006
    ..0 mg/dl, gamma-glutamyl transpeptidase > or =60 IU/l in males and > or =30 IU/l in females...
  57. ncbi Increased serum gamma-glutamyl-transpeptidase concentration is associated with nonalcoholic steatosis and not with cholestasis in patients with chronic hepatitis C
    Federica Benini
    Gastroenterology Unit, Department of Medicine, Spedali Civili and University, Brescia, Italy
    J Gastroenterol Hepatol 22:1621-6. 2007
    ..The mechanism involved in this phenomenon is unclear, and the aim of this study was to investigate factors associated with increased gammaGT levels, specifically looking at the role of cholestasis that frequently accompanies hepatitis C...
  58. doi A kinetic study of gamma-glutamyltransferase (GGT)-mediated S-nitrosoglutathione catabolism
    Valeria Angeli
    National Research Council CNR, Inst for Chemico Physical Processes, Laboratory of Instrumental Analytical Chemistry, Via G Moruzzi 1 56124 Pisa, Italy
    Arch Biochem Biophys 481:191-6. 2009
    ..It is known that gamma-glutamyl transpeptidase (GGT) is one of the enzymes involved in the enzyme-mediated decomposition of GSNO, but no kinetics ..
  59. doi Relationship between gamma-glutamyl transpeptidase activity and garlic greening, as controlled by temperature
    Lei Li
    College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
    J Agric Food Chem 56:941-5. 2008
    ..into a tie connected between storage temperature and garlic greening, it was detected if the gamma-glutamyl transpeptidase (GGT) activity correlated with garlic greening because the activity of this enzyme is very sensitive to ..
  60. pmc Alanine aminotransferase, gamma-glutamyltransferase (GGT) and all-cause mortality: results from a population-based Danish twins study alanine aminotransferase, GGT and mortality in elderly twins
    Abigail Fraser
    Department of Social Medicine, MRC Centre for Causal Analysis in Translational Epidemiology, University of Bristol, Bristol BS8 2BN, UK
    Liver Int 29:1494-9. 2009
    Alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) are widely used markers of liver disease. Several population-based cohort studies have found associations of these liver enzymes with all-cause mortality...
  61. ncbi The Early Detection of Alcohol Consumption (EDAC) test shows better performance than gamma-glutamyltransferase (GGT) to detect heavy drinking in a large population of males and females
    James Harasymiw
    Alcohol Detection Services, Big Bend, WI, USA
    Med Sci Monit 13:PI19-24. 2007
    ..the effectiveness of using the Early Detection of Alcohol Consumption (EDAC) test versus gamma-glutamyltransferase (GGT) to screen for heavy drinking in the general population...
  62. ncbi Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload
    K E Brown
    Gastroenterology Section, John Cochran VAMC, St Louis University Health Sciences Center, Mo 63110 0250, USA
    Free Radic Biol Med 24:545-55. 1998
    ..7-fold), and hydroxyproline (1.5-fold). Total glutathione content was unchanged by iron, but gamma-glutamyl transpeptidase activity (GGT) increased sixfold and CuZn superoxide dismutase (CuZnSOD) activity decreased >9%...
  63. ncbi The gene encoding gamma-glutamyl transpeptidase II in the fission yeast is regulated by oxidative and metabolic stress
    Hyun Jung Kang
    Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Korea
    J Biochem Mol Biol 38:609-18. 2005
    gamma-Glutamyl transpeptidase (GGT, EC 2.3.2.2.) catalyzes the transfer of the gamma-glutamyl moiety from gamma-glutamylcontaining compounds, notably glutathione (GSH), to acceptor amino acids and peptides...
  64. ncbi High prevalence of elevated liver enzymes in blood donors: associations with male gender and central adiposity
    George V Papatheodoridis
    Hellenic Foundation for Gastroenterology and Nutrition, Athens, Greece
    Eur J Gastroenterol Hepatol 19:281-7. 2007
    ....
  65. ncbi Relationship between gamma-glutamyltransferase, lipids and lipoprotein(a) in the general population
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Italy
    Clin Chim Acta 384:163-6. 2007
    ..epidemiological studies have shown a convincing association between increased gamma-glutamyltransferase (GGT) activity and components of the metabolic syndrome, type 2 diabetes, hypertension, ischaemic stroke and myocardial ..
  66. doi Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of gamma-glutamyl transpeptidase
    Frederick H Hausheer
    BioNumerik Pharmaceuticals, Inc, 8122 Datapoint Drive, Suite 1250, San Antonio, TX 78229, USA
    Cancer Chemother Pharmacol 65:941-51. 2010
    ..to the potential prevention of cisplatin-induced nephrotoxicity involves the inhibition of gamma-glutamyl transpeptidase (GGT) activity, mediated by BNP7787-derived mesna-disulfide heteroconjugates that contain a terminal ..
  67. pmc Relationship between alcohol drinking and aspartate aminotransferase:alanine aminotransferase (AST:ALT) ratio, mean corpuscular volume (MCV), gamma-glutamyl transpeptidase (GGT), and apolipoprotein A1 and B in the U.S. population
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, and Clarian Digestive Disease Center, Indiana University School of Medicine, and Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202 5124, USA
    J Stud Alcohol Drugs 71:249-52. 2010
    ..Several blood tests, such as those testing for gamma-glutamyl transpeptidase (GGT) or mean corpuscular volume (MCV), are among the commonly used markers to identify very heavy ..
  68. doi Prospective study of the association of serum gamma-glutamyltransferase with cervical intraepithelial neoplasia III and invasive cervical cancer
    Alexander M Strasak
    Departments of Medical Statistics, Innsbruck Medical University, Innsbruck, Austria
    Cancer Res 70:3586-93. 2010
    Epidemiologic studies indicate that elevated levels of gamma-glutamyltransferase (GGT), a key enzyme of glutathione metabolism, might be associated with increased cancer risk...
  69. ncbi Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells
    A R Sepulveda
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Cell Res 219:494-8. 1995
    gamma-Glutamyl transpeptidase (gamma GT) is a crucial enzyme for the metabolism of xenobiotics and endogenous mediators of biological functions (leukotrienes, prostaglandins, and hepoxillins)...
  70. ncbi Biochemical characteristics of gamma-glutamyl transpeptidase in capillaries from entorhinohippocampal complex of quinolinate-lesioned rat brain
    F Stastny
    Department of Molecular Neurobiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Mol Chem Neuropathol 32:143-61. 1997
    ..Using changes in the activity of membrane-bound gamma-glutamyl transpeptidase (GGT) as a marker of cell damage, we found a significant decrease of this enzyme activity, which was ..
  71. ncbi gamma -glutamyltransferase and its isoform mediate an endoplasmic reticulum stress response
    M Joyce-Brady
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 276:9468-77. 2001
    Although use of multiple alternative first exons generates unique noncoding 5'-ends for gamma-glutamyltransferase (GGT) cDNAs in several species, we show here that alternative splicing events also alter coding exons in mouse GGT to ..
  72. ncbi Development and evaluation of a boronate inhibitor of gamma-glutamyl transpeptidase
    R E London
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Arch Biochem Biophys 385:250-8. 2001
    Gamma-glutamyl transpeptidase (gamma-GT) plays a central role in the metabolism of glutathione and is also a marker for neoplasia and cell transformation...
  73. pmc Gamma-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin
    M H Hanigan
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Am J Pathol 159:1889-94. 2001
    ..cisplatin to glutathione and the subsequent metabolism of the cisplatin-glutathione complex via a gamma-glutamyl transpeptidase (GGT)-dependent pathway in the proximal tubules...
  74. ncbi Characterization and regulation of the gamma-glutamyl transpeptidase gene from the fission yeast Schizosaccharomyces pombe
    Hey Jung Park
    Division of Life Sciences, Kangwon National University, College of Natural Sciences, Chuncheon, Korea
    Can J Microbiol 50:61-6. 2004
    The structural gene for the putative gamma-glutamyl transpeptidase (GGT) was isolated from the chromosomal DNA of the fission yeast Schizosaccharomyces pombe...
  75. ncbi Characterization of a second gene encoding gamma-glutamyl transpeptidase from Schizosaccharomyces pombe
    Hey Jung Park
    Division of Life Sciences, Kangwon National University, Chuncheon, Korea
    Can J Microbiol 51:269-75. 2005
    The first gene encoding gamma-glutamyl transpeptidase (GGTI) of the fission yeast has previously been characterized, and its expression was found to be regulated by various oxidative stress-inducing agents...
  76. pmc 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling
    Hongqiao Zhang
    Department of Environmental Health Science, School of Public Health, University of Alabama at Birmingham, USA
    Am J Respir Cell Mol Biol 34:174-81. 2006
    Gamma-glutamyl transpeptidase (GGT) plays critical roles in glutathione homeostasis and metabolism...
  77. ncbi The effect of modulation of gamma-glutamyl transpeptidase and nitric oxide synthase activity on GSH homeostasis in HepG2 cells
    Inga Kwiecień
    Medical Biochemistry Department, Collegium Medium, Jagiellonian University, Krakow, Poland
    Fundam Clin Pharmacol 21:95-103. 2007
    High glutathione (GSH) level and elevated gamma-glutamyl transpeptidase (gammaGT) activity are hallmarks of tumor cells. Toxicity of drugs and radiation to the cells is largely dependent on the level of thiols...
  78. pmc A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis
    Naoko Ohkama-Ohtsu
    Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa 50011, USA
    Plant Physiol 148:1603-13. 2008
    ..metabolized through the gamma-glutamyl cycle, where GSH is degraded by the sequential reaction of gamma-glutamyl transpeptidase (GGT), gamma-glutamyl cyclotransferase, and 5-oxoprolinase to yield glutamate (Glu) and dipeptides that ..
  79. doi Relationship between soluble CD40 ligand and gamma-glutamyltransferase concentrations in non-drinking, young Type 1 diabetic individuals
    G Zoppini
    Department of Biomedical and Surgical Sciences, Section of Clinical Chemistry, Section of Endocrinology, University of Verona, Verona, Italy
    Diabet Med 25:1283-8. 2008
    To assess the association between circulating levels of soluble CD40 ligand (sCD40L), an emerging cardiovascular risk factor, and gamma-glutamyltransferase (GGT) activity concentrations in Type 1 diabetic subjects.
  80. ncbi Modulation of rat epididymal gamma-glutamyl transpeptidase by nonylphenols
    P C Lee
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    Xenobiotica 30:771-9. 2000
    ..6. It is suggested that NP impair gamma-GTP expression in the epididymis of developing male rat and act in part via the oestrogen receptor...
  81. ncbi gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen
    B Z Carter
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 273:28277-85. 1998
    ..GGL and gamma-glutamyl transpeptidase constitute a small gene family...
  82. ncbi Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Horm Metab Res 37:246-51. 2005
    Elevated serum gamma-glutamyltransferase (GGT) concentrations have been related to features of the metabolic syndrome as well as increased risk of cardiovascular and liver disease...
  83. pmc A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase
    Jarrod B King
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:9059-65. 2009
    Expression of gamma-glutamyl transpeptidase (GGT) in tumors contributes to resistance to radiation and chemotherapy. GGT is inhibited by glutamine analogues that compete with the substrate for the gamma-glutamyl binding site...
  84. ncbi Thyroid hormone modulates the expression of rat liver gammaglutamyltranspeptidase activity
    A Voci
    Instituto di Fisiologia Generale, , Italy
    Horm Metab Res 26:133-6. 1994
    Gammaglutamyltranspeptidase (GGT) activity is considered as a marker of liver phenotype, being maximally expressed in fetal liver and virtually absent in adult mature tissue...
  85. ncbi Prevalence of alcohol and drug abuse in schizophrenic inpatients
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 242:362-72. 1993
    ..Alcoholism Screening Test (MALT), a physical examination and the screening of various laboratory parameters such as GGT and MCV, among others. The results show that substance abuse is a very common problem in schizophrenics...
  86. ncbi Ultrastructural features of danazol-induced cholestasis: a case study
    D Alvaro
    Dipartimento di Medicina Clinica, Universita di Roma La Sapienza, Italy
    Ultrastruct Pathol 20:491-5. 1996
    ..of the severe increase in serum bilirubin and total serum bile salts, transaminases were only slightly elevated and GGT and alkaline phosphatases were almost normal...
  87. ncbi Progressive effects of malachite green at varying concentrations on the development of N-nitrosodiethylamine induced hepatic preneoplastic lesions in rats
    K V Rao
    Cellular Carcinogenesis Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 82:280-6. 1996
    ..on the basis of morphological appearance of the livers, liver weight profile, histological pattern and quantitative GGT activity...
  88. ncbi Triiodothyronine decreases gammaglutamyltranspeptidase expression in cultured rat hepatocytes
    I Demori
    Istituto di Fisiologia Generale, , Italy
    Horm Metab Res 27:221-5. 1995
    Recently, an increase in gammaglutamyltranspeptidase (GGT) activity and mRNA in liver of hypothyroid rats has been reported...
  89. ncbi Comparison of two newly identified tumor markers (CAR-3 and DU-PAN-2) with CA 19-9 in patients with pancreatic cancer
    C Ferrara
    Istituto di Medicina Interna,
    Tumori 77:56-60. 1991
    ..Correlations were found between the behavior of all three markers and that of the cholestasis indices (ALP and GGT)...
  90. ncbi [Signal averaging electrocardiography in chronic alcoholism]
    G Pochmalicki
    Service de cardiologie, , Provins
    Arch Mal Coeur Vaiss 91:309-14. 1998
    ..02). Finally, the presence of LP was also related to the following biological abnormalities: GGT (p = 0.027), ASAT (p = 0.046), ALAT (p = 0.039)...
  91. ncbi Nucleotide sequence and analysis of a gene (chiA) for a chitinase from Streptomyces lividans 66
    K Miyashita
    National Institute of Agro Environmental Sciences, Ibaraki, Japan
    Biosci Biotechnol Biochem 57:1691-8. 1993
    ..A site of initiation of transcription was found approximately 51 bp upstream from the GTG initiation codon...
  92. pmc Human germ cell tumours: expression of gamma-glutamyl transpeptidase and sensitivity to cisplatin
    M H Hanigan
    Department of Cell Biology, University of Virginia, Charlottesville 22908, USA
    Br J Cancer 81:75-9. 1999
    Previous studies have shown that the enzyme-glutamyl transpeptidase (GGT) is essential for the nephrotoxicity of cisplatin. This study was designed to determine whether GGT activity is necessary for the therapeutic effect of the drug...
  93. ncbi Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7,263 treatment courses
    I Gaertner
    University Clinic of Psychiatry and Psychotherapy, Tubingen, Germany
    J Clin Psychopharmacol 21:215-22. 2001
    ..exceeded the established reference range of 3-fold elevations of ALAT, aspartate aminotransferase, gamma-glutamyl transpeptidase, and glutamate dehydrogenase and 2-fold elevations of alkaline phosphatase (AP) during monotherapy with ..
  94. ncbi Benign recurrent intrahepatic cholestasis progressing to progressive familial intrahepatic cholestasis: low GGT cholestasis is a clinical continuum
    Nancy A M van Ooteghem
    Department of Gastroenterology, Gastrointestinal Research Unit, University Medical Center, PO Box 85500, 3508, Utrecht GA, The Netherlands
    J Hepatol 36:439-43. 2002
    ..Characteristically serum GGT activity is low and normal liver structure is preserved...
  95. ncbi Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model
    Andrea Perra
    Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    Carcinogenesis 29:161-8. 2008
    ..were identified by their positivity to the placental form of glutathione S-transferase (GSTP) or to gamma glutamyl transpeptidase. alpha-LA given to rats fed a CMD for 6 weeks dramatically increased the number of GSTP-positive foci as ..
  96. doi The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity
    G B Janssen
    Department of Toxicology and Drug Disposition, Organon, a part of Schering Plough Corporation, P O Box 20, 5340 BH Oss, The Netherlands
    Toxicol Lett 180:196-201. 2008
    ..e. decreased body- and organ weights of thymus and testis, and increased bilirubin and GGT levels) confirmed the comparable estrogenic activity for both compounds at the dose levels tested...
  97. doi Pharmacological intervention of tiferron and propolis to alleviate beryllium-induced hepatorenal toxicity
    Satendra Kumar Nirala
    School of Studies in Zoology, Jiwaji University, Gwalior 474011, India
    Fundam Clin Pharmacol 22:403-15. 2008
    ..Activities of alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transpeptidase, bilirubin, creatinine and urea in the serum and activity of acid phosphatase, alkaline phosphatase, ..
  98. doi Serum level of adiponectin correlated with gender and genotype in patients with chronic hepatitis C
    Qing hua Meng
    Public Health Institute, Jilin University, Qianjin Street No 2699, Changchun, Jilin 130012, China
    Dig Dis Sci 54:1120-7. 2009
    ..that a lower serum adiponectin level was associated with male gender, higher gamma-glutamyltransferase (gamma-GGT), higher albumin, higher TNF-alpha, and steatosis grade...
  99. doi Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats
    Cristina W Nogueira
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    J Appl Toxicol 29:156-64. 2009
    ..alanine (AST) aminotransferases, alkaline phosphatase (ALP), total bilirrubin (TB) and gamaglutamyl transferase (GGT)] and toxicological parameters [thiobarbituric reactive species (TBARS) levels, catalase activity, ascorbic acid, ..
  100. doi Potassium dichromate-induced changes on urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes
    Sergio Lucio Becerra-Torres
    Departamentos de Fisiología y Farmacología, Centro de Ciencias Basicas, Universidad Autonoma de Aguascalientes, Aguascalientes, Mexico
    Drug Chem Toxicol 32:21-5. 2009
    ..was to establish whether potassium dichromate induces changes in the urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes...

Research Grants63

  1. ROHIT J LOOMBA; Fiscal Year: 2014
    ..system (already genotyped: preliminary data suggests 2-2 adrenergic gene effect with serum gamma-glutamyl transpeptidase (GGT), a marker of NAFLD, in this twin cohort) are associated with NAFLD...
  2. Kenneth R Johnson; Fiscal Year: 2016
    ..Aim 5 of this proposal is to refine the chromosomal locations and test candidate genes for three newly mapped loci that contribute to AHL in A/J mice (ahl9 on Chr 11) and NOD/ShiLtJ mice (ahl10 on Chr 1 and ahl11 on Chr 6). ..
  3. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2009
    ABSTRACT The enzyme gamma-glutamyl transpeptidase (GGT) is over-expressed by liver tumors and is elevated in the serum of patients with these tumors...
  4. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
    ..We will construct mutants in each of the genes (ggt, cgaA/cgaB, hly) encoding the TSP catabolic proteins to prove that all of the enzymes in the pathway have been ..
  5. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
    ..reductase;4) the delivery of NO-based bioactivity by RBCs entails an essential role for gamma-glutamyl transpeptidase. Understanding how RBCs regulate the coordinated pulmonary vascular and airway responses that optimize ..
  6. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
    ..Both lung and bladder toxicity will be evaluated with and without pretreatment with acivicin (gamma-glutamyl transpeptidase inhibitor), probenecid (organic anion transport inhibitor), hexahydrocoumarin (aldehyde oxidase inhibitor)..
  7. GLUTATHIONE CONJUGATION--MEDIATOR OF ORGAN TOXICITY
    Serrine Lau; Fiscal Year: 1992
    ..step in the metabolism and membrane transport of GSH and its conjugates involves hydrolysis by gamma-glutamyl transpeptidase (GGT) and the differential toxicity exhibited by the mono- and di-substituted 2- BHQ-GSH conjugates ..
  8. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..Gamma-glutamyl transpeptidase (GGT); a marker for Sertoli cells, we be quantified using a standard enzyme assay...
  9. METABOLIC AND MOLECULAR CONTROL OF MYELOPOIESIS
    Alan Miller; Fiscal Year: 1991
    ..intermediates to LTC and LTD depends on glutathione reductase, glutathione S-transferase and gamma-glutamyl transpeptidase. The genes for two of these enzymes have been localized to chromosomes that are frequently involved in ..
  10. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2005
    ..mercury levels; a dip-stick screening test for urinary protein (confirmed by albumin level); and gamma-glutamyl transpeptidase (gamma-GTP)...
  11. The Role of Gelatinase A in Interstitial Fibrosis
    Sunfa Cheng; Fiscal Year: 2005
    ..Using the mouse gamma- glutamyl transpeptidase II promoter, the tetracycline transactivator protein (tTA) will be restricted to the proximal tubules...
  12. GENE REGULATION OF EPIDIDYMAL GSH METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 2004
    ..Gamma-glutamyl transpeptidase (GGT) is an enzyme that plays a critical role in the metabolism of the antioxidant glutathione (GSH)...
  13. METABOLISM AS A FACTOR IN DRUG-INDUCED NEUROTOXICITY
    TERRENCE MONKS; Fiscal Year: 1999
    ..of quinone-thioethers, in particular their potent effects on cells and tissues expressing gamma-glutamyl transpeptidase, such as renal proximal tubules; and (d) the biochemical and physiological similarities between the blood-..
  14. BENZENE METABOLITES AND HEMATOTOXICITY
    TERRENCE MONKS; Fiscal Year: 2004
    ..in response to HQ-GSH conjugates, (iii) test the hypothesis that metabolite-induced changes in gamma-glutamyl transpeptidase activity (GGT), dipeptidase activity, cysteine transport, and GSH concentrations, precipitate ..
  15. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..In testing this third hypothesis, we will control the effects of hypoxia on the gamma glutamyl transpeptidase knockout mouse...
  16. HEPATOCARCINOGENESIS IN VITRO USING ACTIVATED FOS GENES
    Russell Lebovitz; Fiscal Year: 1993
    ..with either chemical carcinogens or an activated ras gene results in the activation of gamma-glutamyl transpeptidase (gamma GT) and glutathione-S-transferase-P (GSTP), two markers of liver carcinogenesis in vivo...
  17. FATE OF TOXIC CHEMICALS IN HEPATOCYTE AND HEPATOMA CELLS
    Michael Meredith; Fiscal Year: 1992
    ..methionine, while others are proposed to depend on recovery of cysteine by degradation of GSH by Gamma-glutamyl transpeptidase. The proposed research will examine the effect of GSH depletion by diethylmaleate, ethacrynic acid, t-..
  18. PROGENITOR CELLS IN IN VITRO LIVER EXPLANT CULTURES
    Lopa Mishra; Fiscal Year: 2000
    ..Markers indicative of bile duct lineage such as CK14, CK 19 and gamma-glutamyl transpeptidase will also be used...
  19. MOLECULAR CHARACTERIZATION OF BRAIN GSH TRANSPORTERS
    Ram Kannan; Fiscal Year: 1999
    ..of transporters and compare their ion requirements, ii) study contribution of RcGshT and gamma-glutamyl transpeptidase, GGT, to expression of GSH transport in the relevant size fractions using antisense oligonucleotides, iii)..
  20. VASCULAR ENDOTHELIUM FORM AND FUNCTION: EFFECTS OF GLIA
    LAWRENCE DEBAULT; Fiscal Year: 1990
    ..Factor VIII and Thrombomodulin (TM) antigens during regeneration, and induction (or activation) or gamma-glutamyl transpeptidase (GGTP) ion the new endothelium...
  21. ORGAN SPECIFIC DRUGS: CARDIOVASCULAR AND RENAL EFFECTS
    Marian Orlowski; Fiscal Year: 1980
    ..gamma-glutamyl derivatives of drugs are expected to be accumulated at the sites of localization of gamma-glutamyl transpeptidase where the active drug would be released from its inactive precursor and exert its activity...
  22. CHEMICAL TOXICITY AND VITAMIN E REGULATION
    Donald Reed; Fiscal Year: 2001
    ..between vitamin E status, and the biliary secretion of vitamin E, and GSH homeostasis using the gamma-glutamyl transpeptidase (GGT) knockout mice recently developed in the laboratory of Dr. Michael Lieberman, Baylor University...
  23. OXIDATION CHEMISTRY OF INDOLES
    Glenn Dryhurst; Fiscal Year: 2002
    ..released from both neurons and glia, and extracellular conditions that influence the activity of gamma-glutamyl transpeptidase (g-GT), are key factors in MA- and MDMA-induced neurotoxicity...
  24. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
    ..3, follicle stimulating hormone, alpha-inhibin, activin receptor type II, superoxide dismutase 1, gamma-glutamyl transpeptidase, SMAD5, cyclin A1, and oxytocin...
  25. In vivo Transgenic Reporter for Hepatobiliary Toxicity
    Seth Kullman; Fiscal Year: 2005
    ..extend noninvasive detection of acute and chronic biliary toxicity/injury, through induction of a gamma-glutamyl transpeptidase driven fluorescent reporter gene...
  26. Tissue and Tumor Specific Glycosylation of Proteins
    Matthew West; Fiscal Year: 2009
    ..Elevated serum levels of the glycoprotein gamma-glutamyl transpeptidase (GGT) are commonly seen in patients with tumors of the liver and pancreas and in patients with non ..
  27. Rapid in Vivo Assay for Oral Cancer Chemoprevention
    DENNIS SOLT; Fiscal Year: 2002
    ..pouch epithelial (HBPE) model of oral carcinogenesis, focal populations of basal cells exhibiting gamma-glutamyl transpeptidase histochemical activity(GGT foci), and patches of basal cells exhibiting nuclear p53 immunohistochemical ..
  28. FUNCTION OF GAMMA GLUTAMYL LEUKOTRIENASE
    GEETHA HABIB; Fiscal Year: 2005
    DESCRIPTION: Gamma-Glutamyl transpeptidase (GGT) and gamma-glutamyl leukotrienase (GGL), a related enzyme identified in the applicant's laboratory, belong to a small gene family that cleaves glutathione (GSH) and GSH conjugates...
  29. SEQUENTIAL ANALYSIS OF ORAL CARCINOGENESIS
    DENNIS SOLT; Fiscal Year: 1990
    ..exert a promoting action on HBPE with an accompanying selection of focal cell populations rich in gamma-glutamyl transpeptidase activity...
  30. WHAT IS THE METABOLIC FUNCTION OF SELENOPROTEIN W?
    PHILIP WHANGER; Fiscal Year: 2003
    ..We have access to knockout mice deficient in gamma-glutamyl transpeptidase and these will be used to determine the effects of altered glutathione and cystine levels on ..
  31. BIOLOGICAL MARKERS OF ALCOHOL CONSUMPTION AMONG WOMEN
    Linda La Grange; Fiscal Year: 1992
    ..I will attempt to determine if levels of gamma-glutamyl transpeptidase (GGTP), levels of urinary dolichols, or the quantification of carbohydrate-deficient transferrin (CDT) ..
  32. GAMMA GLUTAMYL TRANSPEPTIDASE & LYMPHOCYTE ACTIVATION
    David Karp; Fiscal Year: 2002
    ..Recently, the applicant has found that the ecto-enzyme gamma glutamyl transpeptidase (GGT) is up-regulated upon T cell activation, and is highly expressed by memory T cells...
  33. SENSORS FOR DIAGNOSIS OF ALCOHOL-RELATED LIVER DAMAGE
    Paul Hale; Fiscal Year: 1993
    ..serum enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT), which are frequently associated with alcohol-related organ damage and alcoholism...
  34. AS-GSH CONJUGATION LIMITS AS AVAILABILITY & TOXICITY
    Michael Lieberman; Fiscal Year: 2004
    ..triglutathione (ATG) and methyl arsenic diglutathione (MADG) and identified them in the urine of gamma-glutamyl transpeptidase (GGT)-deficient mice and the bile of wild type mice by use of liquid chromatography/mass spec (LCMS) and ..
  35. REGENERATION AND INTERACTIONS OF BRAIN ENDOTHELIUM
    PASQUALE CANCILLA; Fiscal Year: 1990
    ..3) astrocytes signal the endothelium to increase glucose and amino acid transport and production of gamma glutamyl transpeptidase (GGTP)...
  36. TRANSFORMATION OF HUMAN BREAST EPITHELIAL CELLS IN VITRO
    Satyabrata Nandi; Fiscal Year: 1993
    ..activators (tPA, urokinase), TGF alpha, TGF beta, EGF receptor, glutathione-s-transferase-P, gamma-glutamyl transpeptidase and 0-6 alkyl-DNA-alkyltransferase are reliable, quantitative molecular markers for transformation and ..
  37. MOLECULAR ASPECTS OF THE ROLE OF ANDROGENS IN THE TESTIS
    BARBARA SANBORN; Fiscal Year: 1991
    ..The cellular localization and regulation of testicular gamma-glutamyl transpeptidase mRNA will be studied with the use of cDNA probes...
  38. BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISK
    Frank B Hu; Fiscal Year: 2013
    ..2. To test the hypothesis that increased levels of liver enzymes (fetuin-A, GGT, ALT) are associated with increased risk of T2D, independent of obesity, alcohol intake, and markers of ..
  39. Assiamira Ferrara; Fiscal Year: 2016
    ..Given the high cost of measuring BPA and metabolic biomarkers (glucose, insulin, adiponectin, GGT and ALT);we will obtain these measurements from 300 GDM cases and 600 controls to conduct a prospective, nested ..
  40. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2007
    ..identified three enzymes that are required for the successful metabolism of glutathione: gamma-glutamyltransferase (GGT), cysteinylglycinase (CGase), and cystalysin...
  41. Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl Path
    George I Henderson; Fiscal Year: 2010
    ..of GSH efflux via multidrug resistance protein(s) (Mrp), and two plasma membrane ectopeptidases, ?-glutamyl transpeptidase (GGT) and aminopeptidase N (ApN)...
  42. James C Garbutt; Fiscal Year: 2016
    ..Drinking patterns, anxiety levels, sleep patterns, craving for alcohol, gamma-glutamyl transferase (GGT) and carbohydrate deficient transferring (CDT) will be assessed...
  43. Proteomic Markers of Alcohol Abuse (Phase 1)
    LAWRENCE SNELL; Fiscal Year: 2009
    ..methodology (ProteoSep TM) to accurately measure currently used state markers for excessive alcohol ingestion (GGT, AST and CDT) in plasma and serum samples and develop a measurement, with ProteoSep TM technology, of MAO-B protein ..
  44. George I Henderson; Fiscal Year: 2016
    ..cysteine ligase, glutathione reductase) and second by enhancing regulation of a GSH scavenging system (;-glutamyl transpeptidase (3GT), and aminopeptidase N...
  45. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
    ....
  46. Structural insights into redox homeostasis
    Joseph J Barycki; Fiscal Year: 2010
    ..We will also examine the auto-activation mechanism of g-glutamyl transpeptidase, an ectoenzyme required for glutathione salvage, and the effects of self-processing on catalytic activity...
  47. Cysteine, Related Gene Variants and Breast Cancer Risk
    Walter C Willett; Fiscal Year: 2010
    ....
  48. GLUTATHIONE DEPLETION AND MITOCHONDRIAL COMPLEX I DYSFUNCTION
    Julie Kay Andersen; Fiscal Year: 2011
    ..in inhibition of the GSSG reducing enzyme glutathione reductase (GluRd) and up-regulation of the enzyme g-glutamyl transpeptidase (GGT) which breaks down extracellular GSHto substrates which are transported back into the cell for ..
  49. Pregravid biomarkers of GDM risk, fetal growth and progression to diabetes
    MONIQUE MARIE HEDDERSON; Fiscal Year: 2013
    ..adiponectin, HMW adiponectin, Fetuin-A and LDL-C particle size), 2) inflammation (CRP), and 3) oxidative stress (GGT) assessed before pregnancy, are associated with increased risk GDM...
  50. Gluthathione Depletion /Mitochondrial Complex I Dysfunct
    Julie Andersen; Fiscal Year: 2006
    ..of the GSSG reducing enzyme[unreadable] glutathione reductase (GluRd) and up-regulation of the enzyme g-glutamyl transpeptidase (GGT) which[unreadable] breaks down extracellular GSH to substrates which are transported back into the ..
  51. Polycystin-1 Regulation of Galpha 12 and Integrins in Polycystic Kidney Disease
    Tianqing Kong; Fiscal Year: 2012
    ..leading to cyst development in vivo will be explored using a2 integrin knockout mice, PC1 null heterozyotes and gGT-Cre/QLa12 mice...
  52. Repair of Clustered DNA Damages
    Yoke W Kow; Fiscal Year: 2010
    ..The predominant mutation signature at V599 is T to A transversion mutation (GTG to GAG), changing valine to aspartic acid...
  53. Collagen Glycosylation, Maturation and Mineralization
    Mitsuo Yamauchi; Fiscal Year: 2013
    ..sequentially by hydroxylysyl galactosyltransferase (GT) and, then, galactosylhydroxylysyl glucosyltransferase (GGT)...
  54. Alice Barkan; Fiscal Year: 2016
    ..move easily between laboratories in the different departments and institutes due to the close proximity of all GTG faculty labs and to our faculty's commitment to minimizing bureaucratic barriers to such movement...
  55. JOSHUA D LEE; Fiscal Year: 2016
    ..abstinent, time to first heavy drinking day), treatment retention as a continuous variable, biomarkers including GGT and CDT, and the association of mu opioid receptor Asp40 functional allele status with XR-NTX treatment ..
  56. PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    Neil Kaplowitz; Fiscal Year: 1999
    ..The ultimate goal of this work is the prevention and treatment of liver disease and its extrahepatic complications by exploiting and manipulating hepatic GSH. ..
  57. Exploration of Alcohol Interlock, Biomarker and Psychometric Data
    Paul R Marques; Fiscal Year: 2012
    ..and biological methods of quantifying driver risk;the strongest biomarker predictors of driver risk are PEth, EtG, GGT, and %CDT...
  58. Antioxidant Therapy for Ataxia Telangiectasia
    ROBERT SCHIESTL; Fiscal Year: 2009
    ..b>GGT deficient mice have lower levels of glutathione and show signs of oxidative stress...
  59. Cadmium, K-ras, and Pancreatic Cancer in Egypt
    AMR SOLIMAN; Fiscal Year: 2003
    ..molecular pathologic features of pancreatic cancer tumors of patients from this region [unusually high rate of GGT --> GTT (glycine --> valine) K-ras mutation]...
  60. Atorvastatin, a prenylation inhibitor in acute leukemia.
    Raymond Perez; Fiscal Year: 2003
    ..inhibitors of enzymes that catalyze prenylation, farnesyltransferase (FT) and geranylgeranyltransferase-l and -II (GGT-1, GGT-II), are currently in clinical trials or preclinical models...
  61. CRITICAL CHANGES AND FACTORS IN SKIN TUMOR PROGRESSION
    John DiGiovanni; Fiscal Year: 1992
    ..of various early markers of malignant progression such as loss of high molecular weight keratins, presence of GGT and chromosomal alterations...
  62. PEPTIDYL-ACTINOMYCINS--PRODRUGS AND TUMOR TARGETING
    ANTHONY MAUGER; Fiscal Year: 1990
    ..Glu (Delta)-Gly-Pro- (AMD) and D-Val-Leu-lys-Val-Pro-(AMD) which should be cleaved by delta-glutamyl transferase (GGT) and plasmin respectively...
  63. MOLECULAR MECHANISMS OF INORGANIC LEAD NEUROTOXICITY
    Gary Goldstein; Fiscal Year: 2002
    ..in the neonate of rat brain microvessel growth and on the expression of blood- barrier proteins such as v-glutamyl transpeptidase, p-glycoprotein, or endothelial barrier antigen...