glutaminyl cyclase

Summary

Gene Symbol: glutaminyl cyclase
Description: glutaminyl-peptide cyclotransferase
Alias: GCT, sQC, glutaminyl-peptide cyclotransferase, glutaminyl cyclase, glutaminyl-tRNA cyclotransferase, glutamyl cyclase
Species: human

Top Publications

  1. ncbi False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN)--an update
    K P Dieckmann
    Urologische Abteilung, Albertinen Krankenhaus, Suentelstrasse 11a, D 22457, Hamburg, Germany
    Eur Urol 43:516-21. 2003
  2. ncbi Granulosa cell tumor of the ovary
    Susan Tinsley Schumer
    Program in Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Oncol 21:1180-9. 2003
  3. ncbi Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique
    G Battaglia
    Istituto Oncologico Veneto IOV, via Giogtinian 12, Padova, 35100, Italy
    Surg Endosc 20:1296-8. 2006
  4. ncbi TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
  5. ncbi A population-based risk factor scoring will decrease unnecessary testing for the diagnosis of gestational diabetes mellitus
    Eray Caliskan
    SSK Ankara Maternity and Women s Health Teaching Hospital, Etlik, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:524-30. 2004
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
  7. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
  8. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
  9. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
  10. doi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009

Research Grants

  1. Ethan Dmitrovsky; Fiscal Year: 2014
  2. Mouse model for juvenile granulosa cell tumorogenesis
    ROSEMARY STEINEMETZ; Fiscal Year: 2004
  3. Irva Hertz-Picciotto; Fiscal Year: 2016
  4. Cynthia A Lemere; Fiscal Year: 2015
  5. Jenny N Poynter; Fiscal Year: 2015
  6. A pilot study of DNA methylation in pediatric germ cell tumors
    Jenny N Poynter; Fiscal Year: 2010
  7. Vivian Y H Hook; Fiscal Year: 2014
  8. Daret K St Clair; Fiscal Year: 2016
  9. Agilent 6550 QTOF system for U of Utah
    JAMES ERIC COX; Fiscal Year: 2013
  10. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2003

Detail Information

Publications266 found, 100 shown here

  1. ncbi False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN)--an update
    K P Dieckmann
    Urologische Abteilung, Albertinen Krankenhaus, Suentelstrasse 11a, D 22457, Hamburg, Germany
    Eur Urol 43:516-21. 2003
    ..neoplasia (TIN; or carcinoma in situ of the testis) is the precursor of testicular germ-cell tumours (GCT). It is detected by conventional surgical biopsy of the testis...
  2. ncbi Granulosa cell tumor of the ovary
    Susan Tinsley Schumer
    Program in Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Oncol 21:1180-9. 2003
    Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen...
  3. ncbi Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique
    G Battaglia
    Istituto Oncologico Veneto IOV, via Giogtinian 12, Padova, 35100, Italy
    Surg Endosc 20:1296-8. 2006
    ..The single-band mucosectomy technique was used to remove a granular cell tumor (GCT) of the esophagus. Only 3% of GCTs, which are relatively uncommon neoplasms, arise in the esophagus...
  4. ncbi TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
    Of all malignancies diagnosed in men between 17 and 45 years of age, 60% are germ cell tumors (GCT). GCT arise from carcinoma in situ cells, which are thought to originate from a transformed fetal germ cell, the gonocyte...
  5. ncbi A population-based risk factor scoring will decrease unnecessary testing for the diagnosis of gestational diabetes mellitus
    Eray Caliskan
    SSK Ankara Maternity and Women s Health Teaching Hospital, Etlik, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:524-30. 2004
    ..To determine the effectiveness of a population-based risk factor scoring to decrease unnecessary testing for the diagnosis of gestational diabetes mellitus (GDM)...
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
    ..These findings indicate that in vivo the post-translational conversion of a glutaminyl-peptide into a pyroglutamyl-peptide is neither spontaneous nor abiotic as has been previously proposed...
  7. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
    b>Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally truncated Alzheimer's disease (AD) Abeta peptides in vivo...
  8. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
    ..We describe here the crystal structure of glutaconate CoA-transferase (GCT) from the strictly anaerobic bacterium Acidaminococcus fermentans...
  9. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
    Thirty consecutive patients with relapsing germ cell tumours (GCT) were treated with induction chemotherapy and high-dose chemotherapy consolidation (HDCT)...
  10. doi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009
    Giant cell tumors (GCT) of bone are benign tumors with local aggressiveness that most of the time occur around the metaphyseal area of long bones, often in contact with the articular cartilage...
  11. ncbi Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients
    R J Motzer
    Genitourinary Oncology, Nuclear Medicine, and Renal Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 18:1173-80. 2000
    ..administered plus peripheral blood-derived stem-cell (PBSC) support for patients with germ cell tumors (GCT) who have unfavorable prognostic features in response to conventional-dose salvage programs...
  12. ncbi [Pregnant outcomes and neonatal anthropometry in women with abnormal glucose challenge test and normal oral glucose tolerance test during pregnancy.]
    Hai Tian Chen
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    Zhonghua Fu Chan Ke Za Zhi 44:801-4. 2009
    To evaluate the influences of abnormal glucose challenge test(GCT) on pregnancy outcomes and neonatal anthropometric data in women with normal oral glucose tolerance test(OGTT).
  13. doi Giant cell tumor of the cervical spine: a series of 22 cases and outcomes
    Ma Junming
    The Spine Center, Changzheng Hospital, The Second Military Medical University, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 33:280-8. 2008
    ..A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003...
  14. ncbi Removal of N-terminal polyhistidine tags from recombinant proteins using engineered aminopeptidases
    J Pedersen
    UNIZYME Laboratories, Dr Neergaards vej 17, Horsholm, DK 2970, Denmark
    Protein Expr Purif 15:389-400. 1999
    ..the aminopeptidase dipeptidyl peptidase I (DPPI), either alone or in combination with glutamine cyclotransferase (GCT) and pyroglutamyl aminopeptidase (PGAP)...
  15. ncbi Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning
    K Sugiyama
    Department of Neurosurgery, Hiroshima University Medical Hospital, Japan
    Brain Tumor Pathol 18:115-22. 2001
    Our study of germ cell tumors (GCT) of the central nervous system (CNS) investigated the relationship between tumor histology and patient serum titers of human chorionic gonadotropin (HGC) and alpha-fetoprotein (AFP)...
  16. ncbi Cluster analysis of p53 and Ki67 expression, apoptosis, alpha-fetoprotein, and human chorionic gonadotrophin indicates a favorable prognostic subgroup within the embryonal carcinoma germ cell tumor
    Madhu Mazumdar
    Memorial Sloan Kettering Cancer Center, 307 E 63rd St, 3rd Floor, New York, NY 10021, USA
    J Clin Oncol 21:2679-88. 2003
    ..information provided by alpha-fetoprotein and human chorionic gonadotrophin in the management of germ cell tumor (GCT) patients is a biochemical reflection of tumor differentiation...
  17. ncbi Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
    Clin Exp Metastasis 15:400-9. 1997
    ..Recently, we have identified the expression of both MMP-2 and MMP-9 in primary cultures of human giant cell tumor (GCT) of bone in vitro, and in tissue extracts in vivo. Interestingly, MMP-9 is not secreted by late-passaged GCT cells...
  18. pmc Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular gland
    Shingo Kurabuchi
    Dept of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1 9 20, Chiyoda ku, Tokyo 102 8159, Japan
    J Histochem Cytochem 52:1437-46. 2004
    ..T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male mice by indirect enzyme-labeled antibody ..
  19. ncbi Can adiponectin predict gestational diabetes?
    Sawaek Weerakiet
    Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Gynecol Endocrinol 22:362-8. 2006
    ..and number of fetuses by ultrasound, all women underwent a 1-h glucose challenge test with 50 g glucose load (50-g GCT) between 21 and 27 weeks of GA...
  20. ncbi Determinants of mild gestational hyperglycemia and gestational diabetes mellitus in a large dutch multiethnic cohort
    Rob N M Weijers
    Department of Clinical Chemistry and Haematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Diabetes Care 25:72-7. 2002
    ....
  21. ncbi Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Center for Human Molecular Genetics, Munroe Meyer Institute for Genetics and Rehabilitation, and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    J Interferon Cytokine Res 19:1207-17. 1999
    Giant cell tumor (GCT) of bone is a progressive, potentially malignant process that destroys skeletal tissue...
  22. ncbi Effects of electrohydraulic extracorporeal shock wave lithotripsy on submandibular gland in the rat: electron microscopic evaluation
    Nuray Bayar
    Kirikkale University, Faculty of Medicine, ENT Department, Kirikkale, Turkey
    Int J Pediatr Otorhinolaryngol 63:223-33. 2002
    ..The aim of this experimental study is to investigate the local effects of electrohydraulic ESWL applied to the right submandibular gland of the rats...
  23. doi Stereotactic radiosurgery for pineal and related tumors
    Yoshimasa Mori
    Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital, Nagoya, Japan
    Prog Neurol Surg 23:106-18. 2009
    ..The mean treatment volume was 3.3 ml (range 0.1-22 ml) in GCT cases and 3.7 ml (range 0.3-23 ml) in PPT cases. Prescribed doses around 50% isodose line ranged from 9.9 to 25...
  24. ncbi Giant cell tumor of bone: a model for the in vitro human osteoclast characterization
    M Campanacci
    Centro Interdipartimentale di Ricerche sul Cancro, Giorgio Prodi, , Italy
    Tumori 75:389-95. 1989
    The in vitro growth pattern of cells obtained from bioptic material of ten patients with giant cell tumor of bone (GCT) was investigated...
  25. doi The epidemiology of ovarian granulosa cell tumors: a case-control study
    E A Boyce
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women s Hospital, USA
    Gynecol Oncol 115:221-5. 2009
    This study identified risk factors for ovarian granulosa cell tumors (GCT) through a case-control study comparing women with GCT to women with epithelial ovarian cancers (OC) and general population (GP) controls.
  26. doi Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal ..
  27. ncbi Simultaneous determination of catechins, rutin, and gallic acid in Cistus species extracts by HPLC with diode array detection
    Natale Alfredo Santagati
    Dipartimento di Scienze Farmaceutiche, Università di Catania Viale A Doria 6, 95125 Catania, Italy
    J Chromatogr Sci 46:150-6. 2008
    ..for the simultaneous analysis of five major catechins: (+)-catechin (C), (-)-epicatechin (EC), (-)-gallocatechin (GCT), (-)-epigallocatechin (EGC), (-)-epigallocatechin gallate (EGCG), and the phenolic plant metabolites gallic acid (..
  28. ncbi Relationship between binuclear and multinuclear cells in giant cell tumor of bone
    K Kusuzaki
    Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan
    Anticancer Res 20:2463-7. 2000
    Giant cell tumor of bone (GCT) consists of stromal and multinuclear type tumor cells...
  29. doi Germ cell tumors in the basal ganglia: problems of early diagnosis and treatment
    Yukihiko Sonoda
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Neurosurg Pediatr 2:118-24. 2008
    ..The authors investigated factors related to the diagnosis of these lesions as well as outcome in order to help decrease the time to diagnosis and improve treatment efficacy...
  30. doi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
    Giant cell tumor (GCT) of bone is an aggressive non-cancerous tumor, which consists of multi-nucleated osteoclast-like giant cells, stromal cells, and monocytes...
  31. pmc The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and End Results Program (1975-2004)
    Jennifer L Beebe-Dimmer
    Karmanos Cancer Institute and Wayne State University Department of Internal Medicine, Detroit, MI
    Rare Tumors 1:e52. 2009
    Malignant giant cell tumor (GCT) of bone is a rare tumor with debilitating consequences...
  32. ncbi Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions
    S M Kumta
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
    Life Sci 73:1427-36. 2003
    ..of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
  33. ncbi Regular expression of osteopontin in granular cell tumor: distinctive feature among Schwannian cell tumors
    Nobuo Hoshi
    Department of Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pathol Int 55:484-90. 2005
    For further characterization of S-100 protein-positive granular cell tumor (GCT), the expression of osteopontin (OPN) in the tumor cells was compared with other types of Schwannian cell tumors...
  34. ncbi Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors
    Changning Wang
    Key Laboratory of Oral Biomedical Engineering, Ministry of Education of China, Wuhan University, Wuhan 430079, P R China
    Oncol Rep 15:589-94. 2006
    Cherubism (CBM) and central giant cell granuloma (CGCG) of the jaw and giant cell tumor (GCT) of the long bone are clinically different diseases. Histologically, they are all multinucleated giant cell (MGC)-containing lesions...
  35. doi Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia
    A Guminska
    Division of Reproductive Endocrinology, Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland
    Int J Androl 33:e153-62. 2010
    ..aim of this study was to relate the incidence of testicular germ cell neoplastic lesions (overt germ cell tumours--GCT or testicular carcinoma in situ) to the intensity of testicular organogenesis disturbances (dysgenesis)...
  36. ncbi Identification of markers of possible prognostic value in 57 giant cell tumors of bone
    Gabriella Gamberi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, I 40136 Bologna, Italy
    Oncol Rep 10:351-6. 2003
    Giant cell tumor of bone (GCT) is a neoplasm characterized by the presence of large numbers of multinucleated osteoclast-like giant cells, together with mononuclear spindle-shaped cells...
  37. ncbi Granular cell tumor of the penis shaft: case report and literature review
    A Dema
    Department of Pathology, University of Medicine and Pharmacy V Babes, Timisoara, Romania
    Chirurgia (Bucur) 104:359-62. 2009
    Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rarely involve the male external genitalia. Penile lesions are distinctly uncommon with less than 20 cases reported till now.
  38. ncbi Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: possible involvement in CD68+ macrophage-like cell migration
    M H Zheng
    Department of Orthopaedic Surgery, University of Western Australia, Nedlands, Australia
    J Cell Biochem 70:121-9. 1998
    Giant cell tumor of bone (GCT) is one of a few neoplasms in which the macrophage/osteoclast precursor cells and osteoclast-like giant cells infiltrate the tumor mass...
  39. ncbi Human endogenous retrovirus (HERV)-K transcripts in gonadoblastomas and gonadoblastoma-derived germ cell tumours
    H Herbst
    Institut fur Pathologie, Universitatskrankenhaus Eppendorf, Hamburg, Germany
    Virchows Arch 434:11-5. 1999
    ..abnormal or dysgenetic gonads, often transforming to invasive seminomatous and nonseminomatous germ cell tumours (GCT)...
  40. pmc Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report
    Ran Hong
    Department of Pathology, Chosun University School of Medicine, Gwangju 501 140, South Korea
    World J Gastroenterol 15:3315-8. 2009
    A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin...
  41. ncbi Analysis of oral glucose tolerance test in pregnant women with abnormal glucose metabolism
    Hui Xia Yang
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
    Chin Med J (Engl) 118:995-9. 2005
    ..tolerance (GIGT) and to evaluate the effect of omission of the third-hour plasma glucose (PG) level in OGTT on the sensitivity of diagnosing GDM and GIGT, and the relationship between PG values of 50 g GCT or OGTT and insulin therapy.
  42. doi Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites
    Harpreet Kaur
    Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Int J Clin Oncol 14:78-81. 2009
    Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade...
  43. ncbi Inhibin-activin receptor subunit gene expression in ovarian tumors
    Peter J Fuller
    Prince Henry s Institute of Medical Research and Monash University, Department of Obstetrics and Gynecology, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 87:1395-401. 2002
    Granulosa cell tumors of the ovary (GCT) express the inhibin subunit genes and secrete dimeric inhibin. Transgenic mice null for the alpha-inhibin gene develop GCT...
  44. ncbi MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India
    C B Sanjeevi
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 958:341-4. 2002
    ..Sequence determination of the MIC-A gene identifies trinucleotide repeat (GCT) microsatellite polymorphism in exon 5...
  45. ncbi Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation
    Brian H Le
    Department of Pathology, Penn State University College of Medicine, Hershey, PA, USA
    Arch Pathol Lab Med 128:771-5. 2004
    Granular cell tumor (GCT) is a rare tumor of nerve sheath origin with a predilection for upper aerodigestive tract, skin, and soft tissue...
  46. ncbi Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus
    Te Fu Chan
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital
    Reprod Sci 14:169-74. 2007
    ..Serum RBP4 concentrations at glucose challenge test (GCT) were significantly higher in the GDM group (42.4 +/- 13.8 ng/mL) than in the healthy control group (32.0 +/- 8...
  47. pmc Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  48. ncbi A newly developed gel centrifugation test for quantification of RBC-bound IgG antibodies and their subclasses IgG1 and IgG3: comparison with flow cytometry
    Rainer Lynen
    Department of Transfusion Medicine, University of Gottingen, Gottingen, Germany
    Transfusion 42:612-8. 2002
    Novel gel centrifugation test (GCT) cards were evaluated with respect to their ability to estimate the quantity of IgG on RBCs and the determination of the IgG subclasses IgG1 and IgG3.
  49. ncbi Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120
    Mee Kyung Cha
    Department of Biochemistry, Paichai University, 439 6 Doma 2 Dong Seo Gu, Taejon 302 735, Republic of Korea
    Free Radic Biol Med 42:1736-48. 2007
    ..derived from various cyanobacteria genomes, we designated the seven putative TPx members as VCP, VCT, TCS, and GCT clusters according to the sequence of their conserved catalytic motif...
  50. doi [Germ-cell tumors of the central nervous system in childhood: retrospective study of 13 patients]
    J Voirin
    Service de Neurochirurgie, Departement de Neurochirurgie, bâtiment neurologique, Hopital Central, CHU de Nancy, 29, Avenue du Marechal de Lattre de Tassigny, C O n 34, 54035 Nancy Cedex, France
    Neurochirurgie 54:55-62. 2008
    Germ cell tumors (GCT) of the central nervous system are rare (2% of all brain tumors in children)...
  51. doi Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes
    Sikandar Hayat Khan
    Department of Pathology, PNS Rahat Hospital, Karachi
    J Coll Physicians Surg Pak 19:718-22. 2009
    To compare different cut-off values of fasting and random plasma glucose as a screening test for diagnosis of gestational diabetes in comparison to the 50 grams Glucose Challenge Test (GCT).
  52. pmc Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
    Rachell E Booth
    Department of Chemistry and Biochemistry, Texas State University San Marcos, San Marcos, TX 78666, USA
    BMC Biol 2:2. 2004
    b>Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopeptidases...
  53. ncbi Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)
    K Sawada
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Acta Anat (Basel) 143:241-5. 1992
    ..In either 30- or 90-day-old wild-type male mice, the granular convoluted tubules (GCT) of the glands were more developed, and the relative occupied areas (ROA) of GCT were superior to those of the age-..
  54. ncbi Intense 201 Tl uptake in giant-cell tumour of bone
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan
    Nucl Med Commun 23:595-9. 2002
    ..was to determine the characteristics and clinical usefulness of 201Tl scintigraphy in giant-cell tumour of bone (GCT)...
  55. doi Small fetal abdominal circumference in the second trimester and subsequent low maternal plasma glucose after a glucose challenge test is associated with the delivery of a small-for-gestational age neonate
    J L Bienstock
    Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ultrasound Obstet Gynecol 31:517-9. 2008
    To evaluate the predictive value of a combination of the 1 h 50-g glucose challenge test (GCT) and second-trimester ultrasound measurement of fetal abdominal circumference (AC) in identifying patients who will go on to deliver small-for-..
  56. ncbi [Diagnostic of gestational diabetes mellitus and the prevalence of LGA (Large for Gestational Age)]
    Monika Szymanska
    I Katedra i Klinika Połoznictwa i Ginekologii w Warszawie
    Ginekol Pol 79:177-81. 2008
    ..The aim of the study was to examine the influence of time and diagnostic method of GDM on the prevalence of LGA and pregnancy outcome among patients with gestational diabetes...
  57. doi Colorectal granular cell tumor: a clinicopathologic study of 26 cases
    Aatur D Singhi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:1186-92. 2010
    Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA)...
  58. pmc Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations
    Hsei Wei Wang
    School of Life Sciences, Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    BMC Genomics 11:132. 2010
    ..The second group of tumors requires more extensive drug and irradiation treatment regimens. The mechanisms underlying the differences in incidence and prognosis of the various GCT subgroups are unclear.
  59. ncbi Importance of angulate bodies in the diagnosis of granular cell tumors (schwannomas)
    P H Carstens
    Department of Pathology, University of Louisville School of Medicine, Kentucky 40292
    Ultrastruct Pathol 17:271-8. 1993
    ..ABs appear to have been forgotten, and the diagnosis of GCT currently depends solely upon the presence of large lysosomes...
  60. ncbi Characterization of the Escherichia coli prsA1-encoded mutant phosphoribosylpyrophosphate synthetase identifies a divalent cation-nucleotide binding site
    S G Bower
    Department of Biochemistry, University of Illinois, Urbana 61801
    J Biol Chem 264:10287-91. 1989
    ..was shown by nucleotide sequence analysis to result from substitution of Asp-128 (GAT) in the wild type by Ala (GCT) in prsA1...
  61. ncbi Giant cell tumor of bone in an aged Fischer 344 rat
    T Imai
    Drug Safety Research Laboratories, Eisai Co, Ltd, Hashima, Gifu, Japan
    Toxicol Pathol 26:802-5. 1998
    A giant cell tumor (GCT) was detected on the distal end of the femur in a 98-wk-old male Fischer 344 rat. The yellowish white mass had expanded, compressing adjacent muscle tissues...
  62. ncbi Clinical impact of germ cell tumor cells in apheresis products of patients receiving high-dose chemotherapy
    C Bokemeyer
    Department of Hematology Oncology, University of Tuebingen, Tuebingen
    J Clin Oncol 19:3029-36. 2001
    ..This study analyzed the presence and the clinical importance of contaminating tumor cells in PBSC preparations used to support HD-Ctx in GCT patients.
  63. ncbi Immunohistochemical study of a granular cell tumor on the tongue of a dog
    T S Rallis
    Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 11 St Voutyra str, 546 27, Thessaloniki, Greece
    Vet Clin Pathol 30:62-66. 2001
    A granular cell tumor (GCT; myoblastoma) was diagnosed on the tongue of a 12-year-old English Pointer with clinical signs of mild oral dysphagia. The diagnosis was confirmed by histopathologic examination and immunohistochemistry...
  64. pmc First-line sequential high-dose VIP chemotherapy with autologous transplantation for patients with primary mediastinal nonseminomatous germ cell tumours: a prospective trial
    C Bokemeyer
    Tuebingen University Medical Center II, Department of Hematology, Oncology, Rheumatology and Immunology, Eberhard Karls University, Otfried Mueller Str 10, 70276 Tuebingen, Germany
    Br J Cancer 89:29-35. 2003
    ..high-dose VIP chemotherapy (HD-VIP) in patients with primary mediastinal nonseminomatous germ cell tumours (GCT), 28 patients were enrolled on a German multicentre trial...
  65. ncbi The origin of the neoplastic stromal cell in giant cell tumor of bone
    Manuela Wülling
    Department of Bone Pathology Center of Biomechanics, University Hospital Hamburg Eppendorf, Germany
    Hum Pathol 34:983-93. 2003
    Fibroblastlike stromal cells, which are always present as a component of giant cell tumor of bone (GCT), can be observed in both in vivo and cultured cell samples...
  66. ncbi Multifocal granular cell tumors of the gastrointestinal tract: Immunohistochemical findings compared with those of solitary tumors
    Hiroyuki Mitomi
    Department of Clinical Research Laboratory Pathology, National Sagamihara Hospital, Sagamihara, Japan
    Pathol Int 54:47-51. 2004
    Granular cell tumors (GCT) are infrequently found in the gastrointestinal tract (GIT), and only four previous reports have described lesions occurring simultaneously in different sites...
  67. ncbi Hypertensive disorders in Japanese women with gestational glucose intolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 64:201-5. 2004
    ..Consecutive Japanese women with singleton pregnancies underwent a standard 1h, 50g oral glucose challenge test (GCT) at 24-27 weeks of gestation, followed by a 75g, 2h oral glucose tolerance test (OGTT) if the GCT result exceeded ..
  68. pmc Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures
    Dejan Juric
    Oncology Division, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    Proc Natl Acad Sci U S A 102:17763-8. 2005
    ..Sixty-five genes were sufficient for the construction of a GCT class predictor of high predictive accuracy (100% training set, 96% test set), which might be useful in the ..
  69. ncbi Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96
    W Biskup
    Department of Pediatric Oncology, Hematology and Immunology, Children s Hospital, UKD, Heinrich Heine University, Dusseldorf
    Klin Padiatr 218:303-8. 2006
    ..While TMT is a rare but well recognised phenomenon in adult germ cell tumors (GCT), data on TMT in pediatric GCTs are lacking.
  70. ncbi The Anti-Mullerian hormone and ovarian cancer
    Antonio La Marca
    Mother Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy
    Hum Reprod Update 13:265-73. 2007
    ..Currently, AMH has been shown to be a circulating marker specifically for granulosa cell tumour (GCT). Its diagnostic performance seems to be very good, with a sensitivity ranging between 76 and 93%...
  71. ncbi The impact of maternal age, body mass index and maternal weight gain on the glucose challenge test in pregnancy
    Rinat Hackmon
    Department of Obstetrics and Gynecology, Lenox Hill Hospital, NY 10025, USA
    J Matern Fetal Neonatal Med 20:253-7. 2007
    The aim of this study was to determine whether maternal age, prepregnancy and mid-trimester body mass index (BMI), or excessive mid-pregnancy weight gain predict abnormal glucose challenge test (GCT) results.
  72. doi Obstetric outcomes with a false-positive one-hour glucose challenge test by the Carpenter-Coustan criteria
    Chad A Grotegut
    Department of Obstetrics, Gynecology and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Matern Fetal Neonatal Med 21:315-20. 2008
    Pregnancies complicated by a false-positive one-hour glucose challenge test (GCT), as determined by the National Diabetes Data Group (NDDG) criteria, have higher rates of adverse maternal and neonatal outcomes...
  73. ncbi Testicular granulosa cell tumor, adult type
    Anshu Gupta
    Department of Pathology, Pt BD Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
    Indian J Pathol Microbiol 51:405-6. 2008
    Granulosa cell tumor (GCT) of the adult type is a rare and slow-growing neoplasm in the testis. This tumor may be associated with endocrine manifestations and resemble classic GCT of the ovary morphologically...
  74. pmc Quality of regulatory elements in Drosophila retrogenes
    Yongsheng Bai
    Department of Biology, Box 19498, University of Texas Arlington, Arlington, TX 76019, USA
    Genomics 93:83-9. 2009
    ..the DNA replication-related element (DRE), the Initiator (Inr), and a new over-represented motif that we call the GCT motif...
  75. pmc Giant cell tumor of talus: a case report
    Siddhartha Sharma
    Department of Orthopedics, Government Medical College, Jammu, India
    Cases J 2:74. 2009
    Giant cell tumor of talus is a rare entity. In contrast to GCT of long bones, most cases occur in a younger age group and tend to be multicentric...
  76. pmc Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States
    Sylvain Cecchini
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Vaccine Immunol 16:597-604. 2009
    ..VP2 apparently initiates at a GCT codon (alanine) 273 nucleotides downstream from the VP1 start site and 114 nucleotides upstream from the VP3 ..
  77. pmc Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors
    James E Korkola
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, USA
    J Clin Oncol 27:5240-7. 2009
    Germ cell tumor (GCT) is the most common malignancy in young adult men. Currently, patients are risk-stratified on the basis of clinical presentation and serum tumor markers...
  78. doi Giant cell tumor of the femoral head and neck: result of intralesional curettage
    Hwan Seong Cho
    Department of Orthopaedic Surgery, Kyungpook National University College of Medicine, Kyungpook National University Hospital, Daegu, Korea
    Arch Orthop Trauma Surg 130:1329-33. 2010
    ..The purpose of this study is to review the results of patients managed with intralesional curettage for GCT of the femoral head and neck.
  79. ncbi Cisplatin, etoposide and continuous infusion bleomycin in patients with testicular germ cell tumors: efficacy and toxicity data from a retrospective study
    G Curigliano
    Division of Medical Oncology, Universita di Milano, Milan, Italy
    J Chemother 21:687-92. 2009
    We retrospectively reviewed medical charts of 54 patients who underwent orchidectomy for germ cell tumors (GCT) and received a regimen, given every 3 weeks, consisting of cisplatin 100 mg/m2 day 4 intravenous (i.v...
  80. doi Isolated and synchronous vulvar granular cell tumors: a clinicopathologic study of 17 cases in 13 patients
    John A Papalas
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Gynecol Pathol 29:173-80. 2010
    ..of cells with predominantly vesicular nuclei and prominent nucleoli and was classified as an atypical vulvar GCT. All tumors so examined were reactive for S-100 protein. Eight of 17 tumor excision specimens had positive margins...
  81. doi Snake venomic of Crotalus durissus terrificus--correlation with pharmacological activities
    Dessislava Georgieva
    Institute of Biochemistry and Molecular Biology, University of Hamburg, Laboratory of Structural Biology of Infection and Inflammation, c o DESY, Notkestrasse 85, Building 22a, 22603 Hamburg, Germany
    J Proteome Res 9:2302-16. 2010
    ..serine proteinases, ecto-5'-nucleotidases, metalloproteinases, nerve growth factors, phosphodiesterases, and glutaminyl cyclase. The venom toxin composition correlates with the clinical manifestation of the crotalinae snake bites and ..
  82. doi Fatal lung metastasis secondary to index finger giant cell tumor in an 8-year-old child
    S Jacopin
    Orthopaedic Surgery Department, Assistance Publique Timone Children s Hospital, Marseille Hospitals Group, 264, rue St Pierre, 13385 Marseille Cedex 5, France
    Orthop Traumatol Surg Res 96:310-3. 2010
    We report the case of a 7-year-old girl presenting with giant cell tumor (GCT) of the index finger, complicated by lung metastases...
  83. doi Role of postchemotherapy retroperitoneal lymph node dissection in advanced germ cell tumors
    Carvell T Nguyen
    Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Q10, Cleveland, OH 44195, USA
    Hematol Oncol Clin North Am 25:593-604, ix. 2011
    ..This article reviews the indications, technique, and outcomes of PC-RPLND in the management of advanced GCT.
  84. doi [Childhood cutaneous Abrikossoff tumor]
    Z Lahmam Bennani
    Service de Dermatologie, Centre hospitalo universitaire Farhat Hached, 4002 Sousse, Tunisie
    Arch Pediatr 18:778-82. 2011
    Granular cell tumor (GCT), also known as Abrikossoff tumor, is a rare and benign neoplasm that more commonly affects the oral cavity in adults. We report here 2 childhood cases of a cutaneous granular cell tumor.
  85. doi [Carcinoma in situ of the testis: predisposition, evolution and early detection]
    K Biermann
    Josephine Nefkens Institute, Universitätsklinikum Rotterdam, Erasmus Medical Center, Postbus 2040, 3000 CA, Rotterdam, Niederlande
    Pathologe 32:232-6. 2011
    ..is the common obligate precursor lesion of malignant testicular seminomatous and non-seminomatous germ cell tumors (GCT), which show a steadily increasing incidence in Europe...
  86. doi Management of localized seminoma, stage I-II: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009
    P Warde
    Department of Radiation Oncology, University of Toronto, Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Urology 78:S435-43. 2011
    ..It was also noted that surgery in this setting is technically challenging and could be associated with greater morbidity than in patients with nonseminomatous tumors...
  87. doi Retroperitoneal mixed germ cell tumor mimicking a renal neoplasm: a case report
    Ting Fu Su
    Department of Pathology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Urology 80:714-6. 2012
    ..Pediatric hypertension in a girl secondary to a retroperitoneal mixed GCT (dysgerminoma plus mature monodermal teratoma) has not been reported previously in the literature...
  88. pmc Granular cell breast tumour mimicking infiltrating carcinoma
    Paschalis Gavriilidis
    Department of Surgical Oncology, Theageneio Anticancer Hospital, Thessaloniki, Greece
    BMJ Case Rep 2013:. 2013
    Granular cell tumour (GCT) is a rare, usually benign neoplasm that can mimic carcinoma on breast imaging. GCT can originate anywhere in the body but is most frequently found in the head and neck region, particularly in the tongue...
  89. pmc Association between adiponectin and tumor necrosis factor-alpha levels at eight to fourteen weeks gestation and maternal glucose tolerance: the Parity, Inflammation, and Diabetes Study
    Wanda Nicholson
    Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Womens Health (Larchmt) 22:259-66. 2013
    ..TNF)-alpha concentrations were independently associated and predictive of maternal glucose tolerance, as measured by the 1-hour glucose challenge test (GCT), after adjustment for maternal lifestyle behaviors and body mass index (BMI).
  90. ncbi Granular cell tumor of the uterine cervix. A case report
    Fan Yang
    Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People s Republic of China
    J Reprod Med 58:177-80. 2013
    Granular cell tumor (GCT) is a relatively rare and nearly always benign neoplasm that has been described in many sites and organs including the tongue, skin, subcutaneous tissue, breast, and vulva...
  91. doi [Geriatric complex treatment of proximal femoral fractures? Who profits the most?]
    F Frölich
    Klinikverbund Südwest, Klinikum Sindelfingen Böblingen, Klinik für Unfallchirurgie Sindelfingen, Arthur Gruber Straße 70, 71065, Sindelfingen, Deutschland
    Unfallchirurg 118:858-66. 2015
    Geriatric complex treatment (GCT) is a new type of early rehabilitative care. The main goal is to maintain personal autonomy. GCT includes 21 treatments by physio-, occupational and speech therapists, accompanied by specialized nurses...
  92. pmc Granular cell tumor of the esophagus: a clinicopathological study of 31 cases
    Ling Nie
    Department of Pathology, the Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing 210008, Jiangsu Province, China
    Int J Clin Exp Pathol 7:4000-7. 2014
    ..Nestin, NSE, CD68 and S100 protein were moderate to strong positive. Moreover, a developmental morphology of a GCT was found, which included areas of relatively normal Schwann cells, transitional cells and typical cells of GCTs...
  93. pmc Interrogation of a context-specific transcription factor network identifies novel regulators of pluripotency
    Ritu Kushwaha
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Stem Cells 33:367-77. 2015
    ..The network (GCT(Net)) comprised 1,305 TFs, and its ingenuity pathway analysis identified pluripotency and embryonal development as ..
  94. pmc The hypermetabolic giant: 18F-FDG avid giant cell tumor identified on PET-CT
    Wendi O'Connor
    Department of Radiology, University of North Carolina Hospitals, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina Hospitals, Chapel Hill, NC, USA
    J Radiol Case Rep 8:27-38. 2014
    ..Histology of a fine needle aspiration and open biopsy were consistent with a benign giant cell tumor (GCT) of the bone...
  95. doi Refractory knee giant cell tumor of the synovial membrane treated with intra-articular injection of Infliximab: a case series and review of the literature
    Emanuela Praino
    Rheumatology Unit, Medical School, University of Bari, Bari, Italy
    Int J Rheum Dis 18:908-12. 2015
    Giant cell tumor (GCT) of the synovial membrane, also known as pigmented villonodular synovitis, causes a progressive, relapsing and destructive arthropathy affecting one or more synovial joints...
  96. doi Emerging Therapeutic Targets for Male Germ Cell Tumors
    Christian Daniel Fankhauser
    Department of Urology, University Hospital Zurich, Frauenklinikstrasse 10, Zurich, 8091, Switzerland
    Curr Oncol Rep 17:54. 2015
    ..therapeutic options have increased for various other cancers, little progress has been made in the management of GCT in the last decades...
  97. pmc MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors
    Matteo Rossi
    Istituto Toscano Tumori ITT, Core Research Laboratory CRL, AOU Senese, Siena, Italy
    Oncotarget 7:20981-98. 2016
    Germ cell tumors (GCT) are the most common malignancies in males between 15 and 35 years of age. Despite the high cure rate, achieved through chemotherapy and/or surgery, the molecular basis of GCT etiology is still largely obscure...
  98. pmc Primary Hyperparathyroidism Misdiagnosed as Giant Cell Bone Tumor of Maxillary Sinus: A Case Report
    Leila Aghaghazvini
    Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Advanced Diagnostic and Interventional Radiology Research Center ADIR, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Radiol 13:e13260. 2016
    ..Facial involvement of brown tumor is rare and usually involves the mandible. Giant cell tumor ( GCT) is an expansile osteolytic bone tumor which is very similar in clinical, radiological and histological features to ..
  99. doi Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours
    Klaus Peter Dieckmann
    Department of Urology, Albertinen Krankenhaus, Hamburg, Germany Electronic address
    Eur Urol 71:213-220. 2017
    ..However, the markers α-fetoprotein (AFP), the β-subunit of human chorionic gonadotropin (bHCG), and lactate dehydrogenase (LDH) are expressed in <60% of GCT cases.
  100. doi Thallium-201 Uptake of Giant Cell Tumor: One Step Toward the Differential Diagnosis to Atypically Presenting Osteosarcoma
    Sarah Keller
    1 Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    AJR Am J Roentgenol 208:171-179. 2017
    ..This study aims to assess the feasibility of 201Tl scintigraphy for the differential diagnosis of GCT and atypical OS.
  101. ncbi Impact of renal impairment and granulocyte colony stimulating factor (GCSF) on bleomycin-induced pneumonitis (bleo lung), febrile neutropenia (FN), and survival in patients (pts) with germ cell tumor (GCT) treated with chemotherapy (chemo)
    Ben Tran
    Princess Margaret Hospital, Toronto, ON, Canada Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON, Canada Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada Department of Medical Oncology, Princess Margaret and University of Toronto, Toronto, ON, Canada
    J Clin Oncol 30:328. 2012
    328 Background: Use of GCSF and the development of renal impairment in GCT pts receiving chemo are common, but their effect on toxicity and survival is unclear...

Research Grants40

  1. Ethan Dmitrovsky; Fiscal Year: 2014
    ..will provide critical insights into the Hh pathway in regulating apoptosis, self-renewal or differentiation of GCT or other tumors...
  2. Mouse model for juvenile granulosa cell tumorogenesis
    ROSEMARY STEINEMETZ; Fiscal Year: 2004
    ..In order to test the hypothesis that the FSH-R pathway is involved in GCT pathogenesis, we will utilize a unique mouse model for GCT formation...
  3. Irva Hertz-Picciotto; Fiscal Year: 2016
    ..First, obesity and type 2 or gestational diabetes will be examined in a larger sample, and glucose challenge test (GCT) results for the first time, to determine associations not only with development of ASD and intellectual impairment ..
  4. Cynthia A Lemere; Fiscal Year: 2015
    ..A[unreadable] is generated upon N-terminal truncation of A[unreadable] followed by cyclization by glutaminyl cyclase to convert glutamic acid at residues 3 and 11 to pyroglutamate (A[unreadable]pE3 and A[unreadable]pE11)...
  5. Jenny N Poynter; Fiscal Year: 2015
    ..Cases of pediatric GCT (ages 0-19 years) diagnosed from July 1, 2008-December 31, 2015 will be identified through the CCRN and will be ..
  6. A pilot study of DNA methylation in pediatric germ cell tumors
    Jenny N Poynter; Fiscal Year: 2010
    ..by environmental exposures, with the goal of establishing a large genetic epidemiology study of pediatric GCT in the Children's Oncology Group...
  7. Vivian Y H Hook; Fiscal Year: 2014
    ..aminopeptidase enzymes generate A [unreadable] (3-40/42) which is converted to pGluA[unreadable](3-40/42) by glutaminyl cyclase (QC)...
  8. Daret K St Clair; Fiscal Year: 2016
    ..The Training Program is based in the Graduate Center for Toxicology (GCT), a basic science department in the College of Medicine that grants the Ph.D...
  9. Agilent 6550 QTOF system for U of Utah
    JAMES ERIC COX; Fiscal Year: 2013
    ..This system will complement our current Waters GCT-Premier GC-MS and will be used immediately at full capacity...
  10. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2003
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  11. EGF GENE REGULATION IN KIDNEY AND SUBMANDIBULAR GLAND
    RUTH GUBITS; Fiscal Year: 1990
    ..The major source of mouse EGF is the granular convoluted tubule (GCT) cells of the submandibular salivary gland, which also produce nerve growth factor, renin and kallikreins...
  12. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2007
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  13. CLINICAL CORRELATIVE STUDIES IN GERM CELL TUMORS
    George Bosl; Fiscal Year: 2000
    ..g., bax, bcl-2, p21) will be assessed. His preliminary data in two GCT cell lines (one drug-sensitive (TP53 wild-type) and one drug-resistant (TP53 mutant)) show failure to upregulate ..
  14. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2001
    DESCRIPTION: (Adapted from investigator's abstract) The etiology of germ cell tumors (GCT) is poorly understood...
  15. ANTIOXIDANT ENZYMES AND CARDIAC INJURY
    Daret St Clair; Fiscal Year: 2000
    ..courses but will also participate in a number of team-taught courses offered by the Graduate Center for Toxicology (GCT)...
  16. Therapeutic/Mechanistic Role of Ape1 in Germ Cell Tumors
    Mark Kelley; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Therapy for disseminated germ cell tumors (GCT) has been successful with 70-80% of patients being cured with front line chemotherapy...
  17. BIOLOGY OF HIGH RISK GERM CELL NEOPLASIA
    Lawrence Einhorn; Fiscal Year: 2001
    OVERALL DESCRIPTION (Applicant's Description): Germ cell tumors (GCT), while uncommon, are still the leading cause of cancer in young adult males...
  18. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2003
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  19. Molecular Basis Of Renal Cell Carcinoma Response to SU11428
    Robert J Motzer; Fiscal Year: 2011
    ..These tumor and cell line-based studies lay a foundation for further molecular studies aimed at understanding the sensitivity/resistance of RCC to SU11248. ..
  20. Development of an Aging and Cancer Program at MSKCC
    George Bosl; Fiscal Year: 2007
    ..Through this planning grant, MSKCC will formally expand its research activities in cancer biology and management in the aging population so that it will become a key component of its NCI-funded CCSG. ..
  21. STUDY OF OSTEOPOROTIC FRACTURES
    Teresa Hillier; Fiscal Year: 2005
    ....
  22. Impaired Glucose Challenge Test & Maternal-Fetal Outcomes
    Xinhua Chen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. MOLECULAR CYTOGENETICS OF MULTIPLE MYELOMA
    Raju Chaganti; Fiscal Year: 2001
    ..abstract_text> ..
  24. IMPROVING PRIMARY CARE OF AFRICAN AMERICANS WITH NIDDM
    Lawrence Phillips; Fiscal Year: 2001
    ..Our interventions should delineate approaches effective in a primary care setting, as needed to improve care and prevent complications in urban African-Americans with NIDDM. ..
  25. NEUROENDOCRINE CONTROL OF REPRODUCTIVE BEHAVIOR
    LAUREN RITERS; Fiscal Year: 2003
    ..In addition, this research could lay the groundwork for future studies on the etiology of disorders related to sexual arousal...
  26. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  27. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
  28. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  29. Outcomes of Cx26 Testing in Deaf/Hard of Hearing Adults
    Christina Palmer; Fiscal Year: 2009
    ....
  30. Genetic Epidemiology of Adult Brain Cancer: A Follow-up Study
    Jianming Tang; Fiscal Year: 2008
    ..abstract_text> ..
  31. Cardiovascular Risk in Testicular Cancer Survivors
    David Vaughn; Fiscal Year: 2004
    ..However, prior to initiating an intervention study, these parameters need to be explicated. ..
  32. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2007
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  33. GENES, ANTICARCINOGENS AND COLON NEOPLASMS
    Henry Lin; Fiscal Year: 2006
    ..Results may lead to better understanding of protective mechanisms involving aspirin and nonsteroidal anti-inflammatory drugs. ..
  34. Molecular Genetics of Cervical Cancer Progression
    Murty Vundavalli; Fiscal Year: 2004
    ..The data generated from these studies will be used to determine the clinical significance and to develop a genetic prognostic model for identifying high-risk CINs that progress into invasive cancer. ..
  35. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  36. DNA Methylation as an Epigenetic Host Factor in HIV/AIDS
    Jianming Tang; Fiscal Year: 2006
    ..abstract_text> ..
  37. Connexin 26 Testing in Infants
    Christina Palmer; Fiscal Year: 2005
    ..A large cohort of infants and toddlers will be followed for up to three years to fully evaluate the audiologic phenotype of infants and data will be compared based on Cx26 genotype. ..
  38. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  39. Regulation of embryonic stem cells
    Martin Pera; Fiscal Year: 2005
    ..This project will use stem cell lines ES 01 02 03 04 05 06 on the NIH Embryonic Stem Cell Registry. ..
  40. MAPPING CHROMOSOMES AND GENES IN RELATION TO LEUKEMIA
    Raju Chaganti; Fiscal Year: 2005
    ..In addition, the mapping of NHL breakpoints will provide a platform for addressing breakpoints in this region found in other cancer types. ..