GLUT12

Summary

Gene Symbol: GLUT12
Description: solute carrier family 2 member 12
Alias: GLUT12, GLUT8, solute carrier family 2, facilitated glucose transporter member 12, GLUT-12, glucose transporter type 12, solute carrier family 2 (facilitated glucose transporter), member 12
Species: human

Top Publications

  1. ncbi The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa
    Annette Schurmann
    Institut of Pharmacology and Toxicology, Medical Faculty, Tecnical University of Aachen, Germany
    Cell Tissue Res 307:237-42. 2002
  2. ncbi Expression and localisation of GLUT1 and GLUT12 glucose transporters in the pregnant and lactating rat mammary gland
    Maria L Macheda
    Department of Medicine, St Vincent s Hospital, University of Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia
    Cell Tissue Res 311:91-7. 2003
  3. ncbi Ontogenetic profile and thyroid hormone regulation of type-1 and type-8 glucose transporters in rat Sertoli cells
    Eleonora Carosa
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, 67100 L Aquila, Italy
    Int J Androl 28:99-106. 2005
  4. doi Expression of mRNA for glucose transport proteins in jejunum, liver, kidney and skeletal muscle of pigs
    J R Aschenbach
    Institute of Veterinary Physiology, University of Leipzig, An den Tierkliniken 7, D 04103 Leipzig, Germany
    J Physiol Biochem 65:251-66. 2009
  5. ncbi Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    J Comp Neurol 452:103-14. 2002
  6. doi Screening and identification of differentially expressed genes from chickens infected with Newcastle disease virus by suppression subtractive hybridization
    Daoliang Lan
    College of Life Science and Technology, Southwest University for Nationality, Chengdu, People s Republic of China
    Avian Pathol 39:151-9. 2010
  7. ncbi Characterisation of glucose transporter (GLUT) gene expression in broiler chickens
    T Kono
    Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Br Poult Sci 46:510-5. 2005
  8. ncbi GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons
    Mathieu Widmer
    Department of Physiology, University of Lausanne, 27 rue du Bugnon, 1005 Lausanne, Switzerland
    Endocrinology 146:4727-36. 2005
  9. doi GLUT8, the enigmatic intracellular hexose transporter
    Stefan Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Am J Physiol Endocrinol Metab 296:E614-8. 2009
  10. pmc GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function
    Mathieu Membrez
    Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Genopode Building, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:4268-76. 2006

Research Grants

  1. IGF INDUCED TOXICITY IN PREIMPLANTATION EMBRYOS
    Kelle Moley; Fiscal Year: 2007
  2. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
  3. GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYST
    Kelle H Moley; Fiscal Year: 2012
  4. GLUT8 Overexpression in Cardioprotection
    Maureen J Charron; Fiscal Year: 2010
  5. Glucose Meatbolism in the Human Ovary
    MAUREEN CHARRON; Fiscal Year: 2004
  6. Muhammad Abdul-Ghani; Fiscal Year: 2016
  7. Regulation of Cardiac Glucose Transporters
    MAUREEN CHARRON; Fiscal Year: 2007
  8. Molecular Aspects of Implantation
    Kelle Moley; Fiscal Year: 2006
  9. Maternal Diabetes and Oocyte Quality
    Kelle Moley; Fiscal Year: 2007
  10. REGULATION OF MESANGIAL CELL ECM SYNTHESIS BY GLUT1
    Charles Heilig; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa
    Annette Schurmann
    Institut of Pharmacology and Toxicology, Medical Faculty, Tecnical University of Aachen, Germany
    Cell Tissue Res 307:237-42. 2002
    The glucose transporter 8 (GLUT8) is a recently identified member of the family of sugar transport facilitators. In human tissues GLUT8 is predominantly expressed in testis in a gonadotropin-dependent manner...
  2. ncbi Expression and localisation of GLUT1 and GLUT12 glucose transporters in the pregnant and lactating rat mammary gland
    Maria L Macheda
    Department of Medicine, St Vincent s Hospital, University of Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia
    Cell Tissue Res 311:91-7. 2003
    ..We have used confocal immunofluorescence to localise GLUT1 and GLUT12, a recently identified member of the sugar transporter family, in pregnant and lactating rat mammary gland...
  3. ncbi Ontogenetic profile and thyroid hormone regulation of type-1 and type-8 glucose transporters in rat Sertoli cells
    Eleonora Carosa
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, 67100 L Aquila, Italy
    Int J Androl 28:99-106. 2005
    ..The aim of this paper is to investigate the expression profile of GLUT1 and GLUT8 in the testis during development and in adulthood and analyse the role of T(3) on their expression...
  4. doi Expression of mRNA for glucose transport proteins in jejunum, liver, kidney and skeletal muscle of pigs
    J R Aschenbach
    Institute of Veterinary Physiology, University of Leipzig, An den Tierkliniken 7, D 04103 Leipzig, Germany
    J Physiol Biochem 65:251-66. 2009
    ..facilitated glucose transporter) in intestine revealed the presence of mRNA for GLUT1, GLUT2, GLUT5, GLUT7 and GLUT8, while GLUT3, GLUT4, GLUT10 and GLUT11 were also detectable...
  5. ncbi Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    J Comp Neurol 452:103-14. 2002
    ..The recently identified glucose transporter GLUT8 is uniquely expressed in neuronal cell bodies in the rat hippocampus and therefore may contribute to hippocampal ..
  6. doi Screening and identification of differentially expressed genes from chickens infected with Newcastle disease virus by suppression subtractive hybridization
    Daoliang Lan
    College of Life Science and Technology, Southwest University for Nationality, Chengdu, People s Republic of China
    Avian Pathol 39:151-9. 2010
    ..LAMC1, COL4A1), stress response (DNAJC15, CIRBP), immune response (TIA1, TOX, CMIP), metabolism (RPS15A, RPL32, GLUT8, CYPR21, DPYD, LOC417295), oxidation-reduction (TXN, MSRB3, GCLC), and others...
  7. ncbi Characterisation of glucose transporter (GLUT) gene expression in broiler chickens
    T Kono
    Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Br Poult Sci 46:510-5. 2005
    ..The aim of this study was to identify the extent of mRNA expression of GLUT1, GLUT2, GLUT3 and GLUT8 in chickens intrinsically lacking GLUT4. 2...
  8. ncbi GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons
    Mathieu Widmer
    Department of Physiology, University of Lausanne, 27 rue du Bugnon, 1005 Lausanne, Switzerland
    Endocrinology 146:4727-36. 2005
    b>GLUT8 is a high-affinity glucose transporter present mostly in testes and a subset of brain neurons...
  9. doi GLUT8, the enigmatic intracellular hexose transporter
    Stefan Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Am J Physiol Endocrinol Metab 296:E614-8. 2009
    b>GLUT8 is a class III sugar transporter predominantly expressed in testis and brain...
  10. pmc GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function
    Mathieu Membrez
    Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Genopode Building, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:4268-76. 2006
    b>GLUT8 is a glucose transporter isoform expressed at high levels in testis; at intermediate levels in the brain, including the hippocampus; and at lower levels in the heart and several other tissues...
  11. doi Expression of GLUT8 in mouse intestine: identification of alternative spliced variants
    Amparo Romero
    Department of Physiology, Pharmacology and Toxicology, Experimental Sciences and Health Faculty, University CEU Cardenal Herrera, E 46113 Moncada, Valencia, Spain
    J Cell Biochem 106:1068-78. 2009
    b>GLUT8 is a facilitative glucose transporter composed of 10 exons coding for a 477 amino acids protein. It is mainly expressed in the testis, but it has also been studied in a number of tissues such as brain, adipose tissue, and liver...
  12. ncbi GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 932:129-34. 2002
    Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus...
  13. ncbi Syntaxin 4 expression affects glucose transporter 8 translocation and embryo survival
    Amanda Hoehn Wyman
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 17:2096-102. 2003
    ..b>GLUT8 is a novel IGF-I/insulin-regulated glucose transporter expressed in the mouse blastocyst...
  14. ncbi Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses
    S W Limesand
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, 13243 East 23rd Avenue, Aurora, CO 80010, USA
    Placenta 25:70-7. 2004
    ..The objective of this study was to characterize GLUT8 in the ovine placenta and determine if differences in mRNA and protein concentrations occur in an ovine model of ..
  15. ncbi Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1006:28-35. 2004
    ..effects of stress, streptozotocin (STZ)-induced diabetes and the combined actions of stress and hyperglycemia upon GLUT8 mRNA expression, protein levels and intracellular trafficking in the rat hippocampus...
  16. ncbi Investigation of a QTL region for loin eye area and fatness on pig chromosome 1
    Laura Grapes
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA
    Mamm Genome 17:657-68. 2006
    ..In addition, janus kinase 2 (JAK2) was mapped to a suggestive LEA QTL region and showed association with LEA (p = 0.009), fatness, color, and pH traits in BY...
  17. ncbi GLUT1 and GLUT8 in endometrium and endometrial adenocarcinoma
    Noah A Goldman
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Albert Einstein College of Medicine and Montefiore Medical Center, Albert Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA
    Mod Pathol 19:1429-36. 2006
    ..The following experiments were conducted to quantify and localize the expression of GLUT1 and GLUT8 in benign endometrium and compare this expression to endometrial cancer...
  18. pmc Deletion of glucose transporter GLUT8 in mice increases locomotor activity
    S Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Behav Genet 38:396-406. 2008
    ..In addition, GLUT8 is expressed in some regions of the brain...
  19. pmc Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, P O Box 70622, Johnson City, Tennessee 37614 0622, USA
    J Clin Endocrinol Metab 94:3535-42. 2009
    ..In GLUT4 null mice, insulin-stimulated glucose uptake into muscle was diminished but not eliminated, suggesting that another insulin-sensitive system was present...
  20. pmc The amino acids upstream of NH(2)-terminal dileucine motif play a role in regulating the intracellular sorting of the Class III transporters GLUT8 and GLUT12
    Lauren B Aerni-Flessner
    Departments of Obstetrics and Gynecology and Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110 USA
    Mol Membr Biol 28:30-41. 2011
    ..The class III glucose transporters GLUT8 and GLUT12 both contain a similar [DE]XXXL[LI] dileucine sorting signal in their amino terminus...
  21. ncbi 198 THE EFFECT OF SOURCE AND IN VITRO MATURATION ON THE ABUNDANCE OF MATERNAL mRNA OF SELECTED GENES IN FOLLICULAR BOVINE OOCYTES AND THEIR INFLUENCE ON IN VITRO DEVELOPMENT
    T Somfai
    National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Reprod Fertil Dev 23:199. 2011
    ..The following genes were investigated: GAPDH, G6PDH, ACTB, H2A, CCNB1, MnSOD, OCT4, SOX2, CX43, HSP70, GLUT8, PAP, GDF9, COX1, ATP1A1, CDH1, CTNNB1, AQP3, DYNLL1, DYNC 1/1, and PMSB1...
  22. pmc Expression of conventional and novel glucose transporters, GLUT1, -9, -10, and -12, in vascular smooth muscle cells
    Rajkumar Pyla
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA 30912 2450, USA
    Am J Physiol Cell Physiol 304:C574-89. 2013
    ..phenotype, the relative abundance of key GLUT mRNAs was GLUT1 (∼43%)>GLUT10 (∼26%)>GLUT9 (∼13%)>GLUT12 (∼4%), whereas in the differentiated phenotype the relative abundance was GLUT10 (∼28%)>GLUT1 (∼25%)>..
  23. doi Expression of the glucose transporter GLUT12 in Alzheimer's disease patients
    Jonai Pujol-Gimenez
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    J Alzheimers Dis 42:97-101. 2014
    ..One of the last glucose transporters discovered is GLUT12. The aim of the present work was to investigate the expression of GLUT12 in frontal cortex from AD patients...
  24. doi Gene expression analysis in MCF-7 breast cancer cells treated with recombinant bromelain
    Nour Fouz
    Bioprocess and Molecular Engineering Research Unit BPMERU, Department of Biotechnology Engineering, Faculty of Engineering, International Islamic University Malaysia, P O Box 10, 50728, Kuala Lumpur, Malaysia
    Appl Biochem Biotechnol 173:1618-39. 2014
    ..The extent of changes in genes is related to and involved significantly in gap junction signaling, amyloid processing, cell cycle regulation by BTG family proteins, and breast cancer regulation by stathmin1 that play major roles...
  25. doi GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish
    Vanesa Jiménez-Amilburu
    Institute of BiologyLeiden University, PO Box 9502, 2300 RA Leiden, The NetherlandsZF screens BVJ H Oortweg 19, 2333 CH Leiden, The NetherlandsHubrecht Institute KNAW and University Medical Center Utrecht and Interuniversity3584 CT Utrecht, The Netherlands
    J Endocrinol 224:1-15. 2015
    ..glucose transporters (GLUTs) and the development of cardiomyopathies, we have developed a model for glut12 deficiency in zebrafish...
  26. doi Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods
    Jonai Pujol-Gimenez
    Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain
    Am J Physiol Cell Physiol 308:C1008-22. 2015
    b>GLUT12 is a member of the facilitative family of glucose transporters. The goal of this study was to characterize the functional properties of GLUT12, expressed in Xenopus laevis oocytes, using radiotracer and electrophysiological methods...
  27. pmc Phylogenesis and Biological Characterization of a New Glucose Transporter in the Chicken (Gallus gallus), GLUT12
    Edouard Coudert
    UR83 Recherches Avicoles, Institut National de la Recherche Agronomique, Nouzilly, France
    PLoS ONE 10:e0139517. 2015
    ..A nucleotide sequence is predicted to encode a chicken GLUT12 ortholog and, interestingly, GLUT12 has been described to act as an insulin-sensitive GLUT in mammals...
  28. doi Cloning and functional analysis of goat SWEET1
    L Q Zhu
    Veterinary College, Nanjing Agricultural University, Weigang 1, Nanjing, Jiangsu, China
    Genet Mol Res 14:17124-33. 2015
    ..can reduce glucose absorption in mammary gland epithelial cells with increasing expression of GLUT1, GLUT4, and GLUT12, which may be attributed to glucose efflux arising from the leading role played by goat SWEET1...
  29. doi Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study
    Rachna Verma
    Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Gen Comp Endocrinol 241:57-68. 2017
    ..The decreased effects of insulin inhibited the glucose transport in the testis by suppressing GLUT8. The decreased level of testicular glucose may produce less lactate as energy support to developing germ cells ..
  30. doi Adiponectin Inhibits Nutrient Transporters and Promotes Apoptosis in Human Villous Cytotrophoblasts: Involvement in the Control of Fetal Growth
    Fabien Duval
    GIG EA 7404, Universite de Versailles Saint Quentin en Yvelines, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny le Bretonneux, France
    Biol Reprod 94:111. 2016
    ..that in placental cells, adiponectin 1) inhibits the expression of the major glucose transporters (GLUT1 and GLUT12) and sodium-coupled neutral amino acid transporters (SNAT1, SNAT2, and SNAT4), 2) enhances total ATP production ..
  31. doi Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells
    Ryuta Murakami
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho Kita gun, Kagawa, 761 0793, Japan
    Histochem Cell Biol 146:231-6. 2016
    ..These structures were not immunoreactive for GLUT7, GLUT11, and GLUT12. Our findings support the hypothesis of the transport of intravascular fructose through the epithelial cells of ..
  32. doi Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains
    Masato Mashima
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Neurosci Lett 636:90-94. 2017
    Glucose transporter 8 (GLUT8), a glucose/fructose transporter, has been shown to be expressed in neuronal cells in several brain areas...
  33. doi Effects of first exogenous nutrients on the mRNA levels of atrogin-1/MAFbx and GLUT1 in the skeletal muscles of newly hatched chicks
    Daichi Ijiri
    Department of Agricultural Sciences and Natural Resources, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan Electronic address
    Comp Biochem Physiol A Mol Integr Physiol . 2016
    ..In addition, the mRNA levels of GLUT1 and GLUT8 were increased in the sartorius muscle after the intubation...
  34. ncbi Expression during rat fetal development of GLUT12--a member of the class III hexose transporter family
    Maria L Macheda
    Department of Medicine, St Vincent s Hospital, University of Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia
    Anat Embryol (Berl) 205:441-52. 2002
    ..We used immunohistochemistry to localise GLUT12 protein, a recently identified member of the sugar transporter family, and GLUT1 during rat fetal development...
  35. ncbi Expression and regulation of glucose transporter 8 in rat Leydig cells
    Y Chen
    Research Services, WJB Dorn Veterans Medical Center, Columbia, South Carolina 29201, USA
    J Endocrinol 179:63-72. 2003
    ..Recently, glucose transporter 8 (GLUT8) has been shown to be highly expressed in the testis...
  36. ncbi Glucose transporter GLUT8 translocation in neurons is not insulin responsive
    Bo Chul Shin
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    J Neurosci Res 75:835-44. 2004
    We examined the subcellular distribution of a novel glucose transporter isoform (GLUT8) in murine N2A neuroblastoma cells...
  37. ncbi Two insulin-responsive glucose transporter isoforms and the insulin receptor are developmentally expressed in rabbit preimplantation embryos
    Anne Navarrete Santos
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Grosse Steinstrasse 52, D 06108 Halle Saale, Germany
    Reproduction 128:503-16. 2004
    ..GLUT4 is expressed in bovine preimplantation embryos. A new insulin-responsive isoform, GLUT8, was recently described in mouse blastocysts...
  38. ncbi Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts
    Anne Navarrete Santos
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Grosse Steinstrasse 52, D 06108 Halle Saale, Germany
    Reproduction 128:517-26. 2004
    ..In the present study, the effects of 170 nM insulin on IR, GLUT4 and GLUT8 mRNA levels, Akt and Erk phosphorylation, GLUT4 translocation and methyl glucose transport were studied in ..
  39. ncbi Positherapy: targeted nuclear therapy of breast cancer with 18F-2-deoxy-2-fluoro-D-glucose
    Renee M Moadel
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    Cancer Res 65:698-702. 2005
    ..Substantial differences between GLUT1, GLUT4, and GLUT8 were observed in their distribution within the tumor mass...
  40. ncbi Changes in gene expression involved in energy utilization during chicken follicle development
    H S Seol
    Animal Nutrition, Division of Life Sciences, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Anim Reprod Sci 95:283-94. 2006
    ..GLUT) isoform expression, the level of GLUT1 mRNA increased with follicle development while GLUT2, GLUT3 and GLUT8 mRNA levels were unaffected by follicle development...
  41. ncbi GLUT8 contains a [DE]XXXL[LI] sorting motif and localizes to a late endosomal/lysosomal compartment
    Robert Augustin
    Institute for Human Nutrition, Department of Pharmacology, 14482 Potsdam Rehbrücke, Germany
    Traffic 6:1196-212. 2005
    Glucose transporter 8 (GLUT8) contains a cytoplasmic N-terminal dileucine motif and localizes to a thus far unidentified intracellular compartment...
  42. ncbi Differential expression of glucose transporter GLUT8 during mouse spermatogenesis
    Olga Gomez
    Department of Medicine and Animal Surgery, Experimental Sciences and Health Faculty, Cardenal Herrera CEU University, E 46113 Moncada, Valencia, Spain
    Reproduction 131:63-70. 2006
    b>GLUT8 is a facilitative glucose transporter expressed at high levels in the testis. In this study, we analyzed the GLUT8 expression in mouse testis during spermatogenesis by RT-PCR, Western blot and immunohistochemistry methods...
  43. ncbi Glucose transporter 8 (GLUT8) from the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae)
    Mei Er Chen
    Department of Entomology, Texas A and M University, College Station, 77843 2475, USA
    Arch Insect Biochem Physiol 62:55-72. 2006
    We have cloned the fire ant glucose transporter 8 (GLUT8) cDNA providing the first molecular characterization of a GLUT8 in insects. Glucose is a poly-alcohol and, due to its high hydrophilicity, cannot move across cell membranes...
  44. ncbi 138 THE EFFECT OF FOLLICLE SUPERSTIMULATION ON mRNA LEVELS IN BOVINE OOCYTES COLLECTED BY OVUM PICKUP
    T Somfai
    National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Reprod Fertil Dev 24:181-2. 2011
    ..The following genes were investigated: GAPDH, G6PDH, ACTB, H2A, CCNB1, MnSOD, OCT4, SOX2, CX43, HSP70, GLUT8, PAP, GDF9, COX1, ATP1A1, CDH1, CTNNB1, AQP3, DYNLL1, DYNC 1/1 and PMSB1...
  45. doi GLUT12 functions as a basal and insulin-independent glucose transporter in the heart
    Amanda P Waller
    College of Pharmacy, The Ohio State University, Columbus, OH, USA
    Biochim Biophys Acta 1832:121-7. 2013
    ..Although GLUT4 is the predominant isoform in insulin-sensitive tissues, there is recent evidence that GLUT12 could be a novel second insulin-sensitive GLUT...
  46. doi Lactogenic hormones stimulate expression of lipogenic genes but not glucose transporters in bovine mammary gland
    Y Shao
    Department of Animal Science, University of Vermont, Burlington, VT 05405, USA
    Domest Anim Endocrinol 44:57-69. 2013
    ..fatty acid synthase (FASN), acetyl-CoA carboxylase α (ACACA), stearyol-CoA desaturase (SCD), GLUT1, GLUT8, and GLUT12 were measured by real-time PCR...
  47. pmc Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8
    Christopher P Corpe
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, Intramural Research Program, NIDDK, National Institutes of Health, Bethesda, MD 20892 1372, USA
    J Biol Chem 288:9092-101. 2013
    ..Only GLUT2 and GLUT8, known to be expressed in intestines, transported DHA with apparent transport affinities (Km) of 2.33 and 3...
  48. pmc Functional analyse of GLUT1 and GLUT12 in glucose uptake in goat mammary gland epithelial cells
    Qinghua Yu
    Veterinary College, Nanjing Agricultural University, Nanjing, Jiangsu, PR China
    PLoS ONE 8:e65013. 2013
    ..GLUT1 and GLUT12 could both be expressed in the pregnant and lactating mammary gland to participate in the glucose uptake process...
  49. pmc Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice
    Brian J DeBosch
    MD, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110
    Mol Endocrinol 27:1887-96. 2013
    ..evidence suggests that the ubiquitously expressed class III dual-specificity glucose and fructose transporter, GLUT8, has important metabolic homeostatic functions...
  50. ncbi The effect of ovary storage and in vitro maturation on mRNA levels in bovine oocytes; a possible impact of maternal ATP1A1 on blastocyst development in slaughterhouse-derived oocytes
    Tamas Somfai
    National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Ibaraki 305 0901, Japan jp
    J Reprod Dev 57:723-30. 2011
    ..In immature OPU oocytes, genes related to metabolism (GAPDH), transporters (GLUT8, ATP1A1) and stress resistance protein (HSP70) showed significantly higher expression compared with oocytes ..
  51. doi Conceptus-derived prostaglandins regulate endometrial function in sheep
    Piotr Dorniak
    Center for Reproductive Biology, Department of Animal Sciences, Washington State University, Pullman, Washington, USA
    Biol Reprod 87:9, 1-7. 2012
    ..These results indicate that PGs and IFNT from the conceptus coordinately regulate endometrial functions important for growth and development of the conceptus during the peri-implantation period of pregnancy...
  52. pmc Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization
    Brian J DeBosch
    Department of Pediatrics, Washington University in St Louis School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Endocrinology 153:4181-91. 2012
    ..Enhanced fructose uptake paralleled with increased abundance of the fructose and glucose transporter, GLUT12, in HFrD-fed GLUT8KO mouse enterocytes and in Caco2 cultures exposed to high-fructose medium...
  53. ncbi GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity
    H Doege
    Institute of Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, D 52057 Aachen, Germany
    J Biol Chem 275:16275-80. 2000
    b>GLUT8 is a novel glucose transporter-like protein that exhibits significant sequence similarity with the members of the sugar transport facilitator family (29.4% of amino acids identical with GLUT1). Human and mouse sequence (86...
  54. pmc GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst
    M O Carayannopoulos
    Department of Obstetrics and Gynecology, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:7313-8. 2000
    ..Moreover, the existence of an alternative transporter may explain examples in other tissues of insulin-regulated glucose transport in the absence of GLUT4...
  55. pmc Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
    H Doege
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat der RWTH Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Biochem J 350:771-6. 2000
    ..The next relative of GLUT9 is the glucose transporter GLUT8/GLUTX1 (44.8% amino acid identity with GLUT9). A 2...
  56. ncbi Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos
    R Augustin
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Grosse Steinstrasse 52, D 06097 Halle Saale, Germany
    Mol Reprod Dev 60:370-6. 2001
    ..The embryos were produced in vitro by IVM-IVF. Glut1, Glut3, Glut8, and SGLT-I were expressed in all stages studied. Glut4 transcripts were first detected at the blastocyst stage...
  57. ncbi Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose
    A Scheepers
    Institute of Pharmacology and Toxicology, Technical University of Aachen, Aachen, D 52057, Germany
    Biochem Biophys Res Commun 288:969-74. 2001
    Glucose transporter 8 (GLUT8) is a class III sugar transport facilitator predominantly expressed in testis and insulin-regulated tissues...
  58. ncbi Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons
    Mark Ibberson
    Institute of Pharmacology and Toxicology, University of Lausanne, 27 rue du Bugnon, 1005 Lausanne, Switzerland
    Endocrinology 143:276-84. 2002
    GLUTX1 or GLUT8 is a newly characterized glucose transporter isoform that is expressed at high levels in the testis and brain and at lower levels in several other tissues...
  59. ncbi The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
    H G Joost
    Institute of Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Germany
    Mol Membr Biol 18:247-56. 2001
    ..Like GLUT1-4, they exhibit a tissue/cell-specific expression (GLUT6, leukocytes, brain; GLUT8, testis, blastocysts, brain, muscle, adipocytes; GLUT9, liver, kidney; GLUT10, liver, pancreas; GLUT11, heart, ..
  60. ncbi Identification of a novel glucose transporter-like protein-GLUT-12
    Suzanne Rogers
    Department of Medicine, The University of Melbourne, St Vincent s Hospital Melbourne, Fitzroy, Victoria 3065, Australia 4072
    Am J Physiol Endocrinol Metab 282:E733-8. 2002
    ..Immunoblotting demonstrated GLUT-12 expression in skeletal muscle, adipose tissue, and small intestine. Thus GLUT-12 is potentially part of a second insulin-responsive glucose transport system...
  61. ncbi Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations
    Haruhiko Murata
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    AIDS 16:859-63. 2002
    ..To determine the relative sensitivities of glucose transporter isoforms to the protease inhibitor indinavir and to determine the kinetic mechanism of indinavir-mediated Glut4 isoform inhibition...
  62. ncbi Glucose transporter 8 expression and translocation are critical for murine blastocyst survival
    Anil B Pinto
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Reprod 66:1729-33. 2002
    ..To determine the physiologic role of GLUT8, two-cell embryos were cultured to a blastocyst stage in antisense or sense oligonucleotides to GLUT8...
  63. ncbi Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain
    Raman Sankar
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, CA 90095 1752, USA
    Brain Res Mol Brain Res 107:157-65. 2002
    ..the spatial and temporal distribution of insulin-responsive facilitative glucose transporter isoforms GLUT4 and GLUT8 in the developing mouse brain...
  64. ncbi Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, UK
    Br J Nutr 89:3-9. 2003
    ..Similarly, thirteen members of the family of facilitative sugar transporters (GLUT1-GLUT12 and HMIT; gene name SLC2A) are now recognised...
  65. ncbi Expression and localization of GLUT1 and GLUT12 in prostate carcinoma
    Jenalle D Chandler
    Department of Medicine, St Vincent s Hospital, The University of Melbourne, Melbourne, Australia
    Cancer 97:2035-42. 2003
    ..The authors characterized and cloned the cDNA for a novel glucose transporter, GLUT12, which was identified initially in malignant breast epithelial cells...
  66. ncbi Regulation of hepatic GLUT8 expression in normal and diabetic models
    Naira Gorovits
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 144:1703-11. 2003
    b>GLUT8 is a novel glucose transporter protein that is widely distributed in tissues including liver, a central organ of regulation of glucose homeostasis...
  67. ncbi Differential expression of GLUT12 in breast cancer and normal breast tissue
    Suzanne Rogers
    The University of Melbourne, Department of Medicine, St Vincent s Hospital Melbourne, Fitzroy, Melbourne, Victoria 3065, Australia
    Cancer Lett 193:225-33. 2003
    ..We previously identified a novel glucose transporter protein, GLUT12, in the MCF7 malignant breast epithelial cell line...
  68. ncbi Mitogenic and anti-apoptotic activity of insulin on bovine embryos produced in vitro
    R Augustin
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Halle Saale, Germany
    Reproduction 126:91-9. 2003
    ..and by quantification of the relative amounts of mRNA for Bax and Bcl-XL; and (iv) expression for Glut1, Glut3 and Glut8 transcripts was compared between embryos cultured in the presence or absence of insulin...
  69. ncbi Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 308:43-9. 2003
    ..Both GLUT-10 and GLUT-12 expression was also found in human adipose tissue (subcutaneous and omental) and SGBS adipocytes. It is concluded that white fat expresses a wide range of facilitative glucose transporters...
  70. ncbi Broiler chickens (Ross strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA
    Yoshinori Seki
    Animal Nutrition, Division of Life Sciences, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Gen Comp Endocrinol 133:80-7. 2003
    Identification of insulin-responsive glucose transporter proteins, GLUT4 and GLUT8, was attempted in chickens that characteristically are hyperglycemic and insulin resistant...
  71. ncbi Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes
    Suzanne Rogers
    Department of Medicine, The University of Melbourne, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Biochem Biophys Res Commun 308:422-6. 2003
    ..recently identified and cloned the cDNA of a new member of the glucose transporter family that has been designated GLUT12. GLUT12 possesses the structural features critical to facilitative transport of glucose but the key to ..
  72. ncbi Glucose transporter proteins (GLUT) in human endometrium: expression, regulation, and function throughout the menstrual cycle and in early pregnancy
    Michael von Wolff
    Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, 69115 Heidelberg, Germany
    J Clin Endocrinol Metab 88:3885-92. 2003
    ..isoforms are expressed, whereas glucose transporters, involved in insulin-dependent glucose uptake (GLUT2, GLUT4, GLUT8), could not be detected...
  73. pmc Implications of glucose transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress
    Charles Heilig
    Division of Nephrology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 947, Baltimore, MD 21205, USA
    Am J Pathol 163:1873-85. 2003
    ..GLUT3 was unchanged. GLUT8 and GLUT12 were also expressed and unchanged in GT1(+/-)...
  74. ncbi GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern
    M Gaster
    Department of Endocrinology, Odense University Hospital, 5000 Odense, Denmark
    Pflugers Arch 448:105-13. 2004
    ..The mRNA for three of these, the glucose transporters (GLUT) GLUT8, GLUT11 and GLUT12, have been detected in human skeletal muscle...
  75. ncbi Identification of the facilitative glucose transporter 12 gene Glut12 in mouse preimplantation embryos
    Yuchan Zhou
    Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Gene Expr Patterns 4:621-31. 2004
    In this study we report the cloning and characterisation of the mouse Glut12 gene and examine for the first time its expression pattern in the earliest stages of development...
  76. ncbi Bovine glucose transporter GLUT8: cloning, expression, and developmental regulation in mammary gland
    Feng qi Zhao
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington, Vermont 05405, USA
    Biochim Biophys Acta 1680:103-13. 2004
    b>GLUT8 is a newly identified member of the facilitative glucose transporter family, which characteristically exhibits high-affinity glucose transport activity...
  77. ncbi Expression of GLUT12 in the fetal membranes of the human placenta
    N M Gude
    Department of Perinatal Medicine, Royal Women s Hospital, Carlton, Australia
    Placenta 26:67-72. 2005
    The aim of this study was to characterize the expression of the novel glucose transporter GLUT12 in the fetal membranes of the human placenta...
  78. ncbi Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions
    Mario Schiffer
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Renal Physiol 289:F186-93. 2005
    ..glucose and plasma glucose homeostasis, the tissue distribution and regulation of glucose transporter GLUT8, a new member of the glucose transporter family with important functions in cellular survival, were examined...
  79. ncbi Cloning and expression of bovine glucose transporter GLUT12
    Peter J Miller
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, RM 219 Terrill Building, 570 Main Street, Burlington, Vermont 05405, USA
    Mamm Genome 16:873-83. 2005
    b>GLUT12 is a new member of facilitative glucose transporters. It was originally cloned from a human breast cancer cell line and its expression has been detected in rat mammary gland...
  80. ncbi Identification and characterization of p49/STRAP as a novel GLUT4-binding protein
    Ivonne Lisinski
    EDMNS DB NIDDK NIH, Bethesda, MD, USA
    Biochem Biophys Res Commun 344:1179-85. 2006
    ..domain of p49 in adipose cells reduces protein synthesis and cell-surface expression of GLUT4, but not of GLUT8. Moreover, cell-surface expression of a p49-binding-deficient GLUT4 mutant (ED/QN) is also reduced...
  81. ncbi Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex
    Ulrike Schmidt
    German Institute of Human Nutrition, Potsdam, Nuthetal, Germany
    J Cell Sci 119:2321-31. 2006
    The glucose transporter GLUT8 cycles between intracellular vesicles and the plasma membrane. Like the insulin-responsive glucose transporter GLUT4, GLUT8 is primarily located in intracellular compartments under basal conditions...
  82. ncbi Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Am J Physiol Endocrinol Metab 291:E1067-73. 2006
    ..and cDNA standards were cloned for GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9, GLUT10, GLUT11, GLUT12, and GAPDH. Seven of these eleven hexose transporters were detectable in normal human muscle...
  83. ncbi Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University, James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Diabetes Care 30:925-31. 2007
    ..This study was undertaken to quantify the expression of muscle GLUT in type 2 diabetes and to determine if treatment with an insulin-enhancing thiazolidenedione drug, pioglitazone, would alter its expression...
  84. ncbi Differential expression of facilitative glucose transporters in normal and tumour kidney tissues
    Nobuyasu Suganuma
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    BJU Int 99:1143-9. 2007
    ....
  85. ncbi Expression and regulation of glucose transporters in the bovine mammary gland
    F Q Zhao
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington 05405, USA
    J Dairy Sci 90:E76-86. 2007
    ..However, the bovine lactating mammary gland also expresses GLUT3, GLUT4, GLUT5, GLUT8, GLUT12, and sodium-dependent SGLT1 and SGLT2 at different levels...
  86. ncbi The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and sperm
    Sung Tae Kim
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Reprod Sci 14:445-55. 2007
    ..b>GLUT8, GLUT9a, and GLUT9b proteins are expressed in the most intraseminiferous tubula cells and Leydig cells...
  87. ncbi Decreased [18F]fluoro-2-deoxy-d-glucose incorporation and increased glucose transport are associated with resistance to 5FU in MCF7 cells in vitro
    Tim A D Smith
    PET Unit, Department of Biomedical Physics, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucl Med Biol 34:955-60. 2007
    ..Resistant cells selected by exposure to chemotherapy agents may exhibit differences in [18F]fluoro-2-deoxy-d-glucose (FDG) incorporation, as compared with sensitive cells...
  88. ncbi Mitogen-stimulated and rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells
    Amy L Wilson-O'Brien
    The University of Melbourne, Department of Medicine, St Vincent s Hospital, Melbourne, Fitzroy, Victoria 3065, Australia
    Endocrinology 149:917-24. 2008
    We hypothesized that glucose transporter 12 (GLUT12) is involved in regulation of glucose flux in distal renal tubules in response to elevated glucose...
  89. pmc Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa
    Verena Gawlik
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Mol Membr Biol 25:224-35. 2008
    b>GLUT8 is a class 3 sugar transport facilitator which is predominantly expressed in testis and also detected in brain, heart, skeletal muscle, adipose tissue, adrenal gland, and liver...
  90. pmc Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12 in Chinese hamster ovary cells
    Lauren B Flessner
    Department of Obsetrics and Gynecology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Traffic 10:324-33. 2009
    ..The recently identified class III GLUT12 is predominantly expressed in insulin-sensitive tissues such as heart, fat and skeletal muscle...
  91. doi Expression and regulation of insulin and the glucose transporter GLUT8 in the testes of diabetic rats
    O Gomez
    Departamento de Medicina y Cirugia Animal, Universidad CEU Cardenal Herrera, Moncada 46113, Valencia, Spain
    Horm Metab Res 41:343-9. 2009
    ..The aim of this study was to analyze the levels and localization of the glucose transporter GLUT8 and insulin in the testes of rats induced to a diabetic status by a single dose of streptozotocin...
  92. pmc Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction
    Muhammed Kasim Diril
    Institute of Chemistry and Biochemistry, Department of Membrane Biochemistry, Freie Universität and Charité Universitätsmedizin Berlin, Takustrasse 6, Berlin, Germany
    FEBS J 276:3729-43. 2009
    The class III sugar transport facilitator GLUT8 co-localizes with the lysosomal protein LAMP1 in heterologous expression systems...
  93. ncbi Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma
    Philippe Fonteyne
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, The Netherlands
    Histol Histopathol 24:971-7. 2009
    ..In patients that underwent primary surgery, Hscores of GLUT8 (micro 6.7; sd3.3) and GLUT1 (micro 5.5; sd: 5.3) were significantly higher than Hscores of GLUT9 (micro 2.2; sd 1...
  94. doi High glucose inhibits HCO3(-) and fluid secretion in rat pancreatic ducts
    Sachiko Futakuchi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pflugers Arch 459:215-26. 2009
    ..Sodium-dependent glucose cotransporter 1 (SGLT1), glucose transporter (GLUT)1, GLUT2, and GLUT8 transcripts were detected by reverse transcriptase polymerase chain reaction in isolated ducts...
  95. pmc Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Med Sci Sports Exerc 42:96-106. 2010
    ..To determine whether cycle training of sedentary subjects would increase the expression of the principle muscle glucose transporters, six volunteers completed 6 wk of progressively increasing intensity stationary cycle cycling...
  96. pmc The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences
    Bettina Heidecker
    Interdisciplinary Stem Cell Institute, University of Miami, Miller School of Medicine, Biomedical Research, Miami, FL 33101, USA
    Eur Heart J 31:1188-96. 2010
    ....
  97. doi Developmental competence and mRNA expression of preimplantation in vitro-produced embryos from prepubertal and postpubertal cattle and their relationship with apoptosis after intraovarian administration of IGF-1
    J Zaraza
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Mariensee, Neustadt, Germany
    Theriogenology 74:75-89. 2010
    ..on (1) oocyte developmental competence, (2) the expression pattern of six developmentally important genes (GLUT3, GLUT8, AKT1, BCL-XL, BAD, and BAX), and (3) its relationship with apoptosis (female Holstein-Friesian)...
  98. pmc Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene
    Charles E Foulds
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1090-105. 2010
    ..This study is a valuable resource because it represents the first genome-wide analysis of a mammalian RNA coregulator...
  99. ncbi Glucose transport in interlobular ducts isolated from rat pancreas
    Sachiko Futakuchi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Invest 56:308-11. 2009
    ..express Na(+)-dependent glucose transporter, SGLT1 and Na(+)-independent glucose transporters, GLUT1, GLUT2, and GLUT8. We examined transepithelial glucose transport by pancreatic duct...
  100. pmc Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathway
    Anthony J Cura
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:15430-9. 2010
    ..GLUT1, GLUT8, and GLUT9 mRNAs are detected in bEnd...
  101. doi LPS-induced inflammation downregulates mammary gland glucose, fatty acid, and L-carnitine transporter expression at different lactation stages
    Binbing Ling
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan, Canada S7N5C9
    Res Vet Sci 89:200-2. 2010
    ..p.) injection. Fold differences in the mRNA expression of glucose transporters Glut1, Glut8 and Sglt1, fatty acid transporters Fatp1, Fatp4 and Fabp3, and L-carnitine transporters Octn1, Octn2, and Octn3 ..

Research Grants10

  1. IGF INDUCED TOXICITY IN PREIMPLANTATION EMBRYOS
    Kelle Moley; Fiscal Year: 2007
    ..IGF-1 receptor resulting in decreased glucose uptake via translocation of the facilitative glucose transporter, GLUT8. This decrease results in apoptosis, and miscarriage when these blastocysts are transferred back into foster mice...
  2. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..Are protein and mRNA expression of GLUT8, GLUT9a and GLUT9b in the testes affected by exposure to TCDD? Is the location of the transporters altered? ..
  3. GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYST
    Kelle H Moley; Fiscal Year: 2012
    ..Specific Aim 3 investigates the possible role GLUT8 may play in autophagy in the mouse blastocyst...
  4. GLUT8 Overexpression in Cardioprotection
    Maureen J Charron; Fiscal Year: 2010
    ..G4 Null mice show an increased expression of GLUT8, a new member of the glucose transporter family...
  5. Glucose Meatbolism in the Human Ovary
    MAUREEN CHARRON; Fiscal Year: 2004
    ..GLUTx1, also known as GLUT8, is a recently discovered glucose transporter that appears to be sex steroid regulated...
  6. Muhammad Abdul-Ghani; Fiscal Year: 2016
    ..uptake (IMGU) with the stepped euglycemic insulin clamp, (ii) the protein content of insulin dependent (GLUT4/GLUT12) and glucose-mediated glucose transporters (GLUT1/GLUT3/GLUT11) and gene expression in skeletal muscle in subjects ..
  7. Regulation of Cardiac Glucose Transporters
    MAUREEN CHARRON; Fiscal Year: 2007
    ..GLUT1 and GLUT8 are also expressed in the heart...
  8. Molecular Aspects of Implantation
    Kelle Moley; Fiscal Year: 2006
    ..abstract_text> ..
  9. Maternal Diabetes and Oocyte Quality
    Kelle Moley; Fiscal Year: 2007
    ..Treatment that is more aggressive may be indicated for these patients throughout their reproductive years may be indicated. ..
  10. REGULATION OF MESANGIAL CELL ECM SYNTHESIS BY GLUT1
    Charles Heilig; Fiscal Year: 2002
    ..Deletion mutation analysis of activated reporter constructs will locate the limiting sequences of these cis-acting elements. ..