GluR2

Summary

Gene Symbol: GluR2
Description: glutamate ionotropic receptor AMPA type subunit 2
Alias: GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate receptor 2, AMPA-selective glutamate receptor 2, gluR-2, gluR-B, glutamate receptor B flip isoform, glutamate receptor, ionotropic, AMPA 2
Species: human

Top Publications

  1. ncbi Neurochemistry of the mammalian cone 'synaptic complex'
    N Vardi
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, 19104 6058, USA
    Vision Res 38:1359-69. 1998
  2. pmc Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism
    Rebeca Mejias
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Howard Hughes Medical Institute, Predoctoral Training Program in Human Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:4920-5. 2011
  3. ncbi New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2
    John C M Tsibris
    Department of Obstetrics and Gynecology, University of South Florida, 4 Columbia Drive, Room 524, Tampa, FL 33606, USA
    Biochem Biophys Res Commun 312:249-54. 2003
  4. doi The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells
    Francesca Beretta
    DTI Dulbecco Telethon Institute, Via Vanvitelli 32, Milan 20129, Italy
    Eur J Neurosci 30:25-34. 2009
  5. pmc Developmental regulation of the toxin sensitivity of Ca(2+)-permeable AMPA receptors in cortical glia
    O Meucci
    Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637, USA
    J Neurosci 16:519-30. 1996
  6. ncbi Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism
    J Noel
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, United Kingdom
    Neuron 23:365-76. 1999
  7. ncbi Disruption of the GluR2-NSF interaction protects primary hippocampal neurons from ischemic stress
    G S Ralph
    Division of Medicine, University of Bristol, Marlborough Street, Bristol, BS2 8HW
    Mol Cell Neurosci 17:662-70. 2001
  8. ncbi Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice
    D T Joo
    Department of Anaesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 91:1329-41. 1999
  9. ncbi Binding of 5'-GMP to the GluR2 AMPA receptor: insight from targeted molecular dynamics simulations
    Jesús Mendieta
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma, E 28049 Cantoblanco, Madrid, Spain
    Biochemistry 44:14470-6. 2005
  10. pmc Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia
    Frederick Colbourne
    Department of Psychology, Faculty of Science, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 100:2906-10. 2003

Research Grants

  1. Characterizing an AMPA Receptor Splice Modulator in Preventing Epileptogenesis
    Melanie K Tallent; Fiscal Year: 2012
  2. Regulation of calcium-permeable AMPA receptors in associative memory
    ROGER LEE CLEM; Fiscal Year: 2012
  3. Steven J Tavalin; Fiscal Year: 2015
  4. Anatomy of postsynaptic plasticity in hippocampus
    Richard J Weinberg; Fiscal Year: 2012
  5. AMYGDALA AMPA GLUR2 DELETION AND OPIOID DEPENDENCE
    Michael J Glass; Fiscal Year: 2010
  6. GLUTAMATE RECEPTORS AND OPIOID DEPENDENCE: MOLECULES, CIRCUITS AND BEHAVIOR
    Michael J Glass; Fiscal Year: 2013
  7. Terunaga Nakagawa; Fiscal Year: 2014
  8. Allosteric Modulators of Glutamate Receptors
    Robert E Oswald; Fiscal Year: 2010
  9. Defining the epitope in anti-AMPA receptor encephalitis
    DAVID ROBINSON LYNCH; Fiscal Year: 2013
  10. Role of AMPA receptors in the nucleus accumbens shell in morphine depedence
    Elena Chartoff; Fiscal Year: 2009

Detail Information

Publications436 found, 100 shown here

  1. ncbi Neurochemistry of the mammalian cone 'synaptic complex'
    N Vardi
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, 19104 6058, USA
    Vision Res 38:1359-69. 1998
    ..Surprisingly, invaginating bipolar dendrites in the cat also express the AMPA receptor subunits, GluR2/3 and GluR4...
  2. pmc Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism
    Rebeca Mejias
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Howard Hughes Medical Institute, Predoctoral Training Program in Human Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:4920-5. 2011
    ..1 (GRIP1) is a neuronal scaffolding protein that interacts directly with the C termini of glutamate receptors 2/3 (GluA2/3) via its PDZ domains 4 to 6 (PDZ4-6). We found an association (P<0...
  3. ncbi New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2
    John C M Tsibris
    Department of Obstetrics and Gynecology, University of South Florida, 4 Columbia Drive, Room 524, Tampa, FL 33606, USA
    Biochem Biophys Res Commun 312:249-54. 2003
    ..b>GluR2, a subunit of a ligand-gated cation channel, is up-regulated in leiomyomata relative to myometrium by 15- to 30-..
  4. doi The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells
    Francesca Beretta
    DTI Dulbecco Telethon Institute, Via Vanvitelli 32, Milan 20129, Italy
    Eur J Neurosci 30:25-34. 2009
    ..We found that GluR2 is absent in fast-growing GBM-derived tumour stem cells and high-grade glioma specimens, but is expressed in slow-..
  5. pmc Developmental regulation of the toxin sensitivity of Ca(2+)-permeable AMPA receptors in cortical glia
    O Meucci
    Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637, USA
    J Neurosci 16:519-30. 1996
    ..of the expression of AMPA-receptor subunits showed an increase in the concentration of glutamate receptor-2 (GluR2) in CG-4 cells as they differentiated into type II astrocytes and oligodendrocytes...
  6. ncbi Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism
    J Noel
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, United Kingdom
    Neuron 23:365-76. 1999
    Here, we show that disruption of N-ethylmaleimide-sensitive fusion protein- (NSF-) GluR2 interaction by infusion into cultured hippocampal neurons of a blocking peptide (pep2m) caused a rapid decrease in the frequency but no change in ..
  7. ncbi Disruption of the GluR2-NSF interaction protects primary hippocampal neurons from ischemic stress
    G S Ralph
    Division of Medicine, University of Bristol, Marlborough Street, Bristol, BS2 8HW
    Mol Cell Neurosci 17:662-70. 2001
    A specific interaction between the AMPA receptor subunits GluR2 and GluR3 and the fusion protein NSF has recently been identified...
  8. ncbi Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice
    D T Joo
    Department of Anaesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 91:1329-41. 1999
    ..Because AMPA receptor complexes that lack the GluR2 subunit are relatively insensitive to pentobarbital inhibition, GluR2 null mutant mice provide a novel tool to ..
  9. ncbi Binding of 5'-GMP to the GluR2 AMPA receptor: insight from targeted molecular dynamics simulations
    Jesús Mendieta
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma, E 28049 Cantoblanco, Madrid, Spain
    Biochemistry 44:14470-6. 2005
    ..nucleotide, we have tried to understand how these molecules interact with the agonist-binding site of the GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor...
  10. pmc Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia
    Frederick Colbourne
    Department of Psychology, Faculty of Science, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 100:2906-10. 2003
    ..Neuronal death is preceded by down-regulation specific to CA1 of GluR2, the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit that limits Ca(2+) influx...
  11. ncbi Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis
    Shin Kwak
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    J Mol Med (Berl) 83:110-20. 2005
    ..The Ca2+ conductance of AMPA receptors differs markedly depending on whether the GluR2 (or GluR-B) subunit is a component of the receptor...
  12. ncbi Glutamate receptor subunit 2-selective antibody shows a differential distribution of calcium-impermeable AMPA receptors among populations of neurons
    R S Petralia
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892 4162, USA
    J Comp Neurol 385:456-76. 1997
    ..AMPA receptor complexes that contain the AMPA-type glutamate receptor subunit 2 (GluR2) are responsible for the low calcium permeability typical of most AMPA receptors, and the absence of GluR2 may be ..
  13. ncbi Primary afferent terminals in spinal cord express presynaptic AMPA receptors
    Chun Rong Lu
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 22:9522-9. 2002
    Larger dorsal root ganglion neurons are stained by an antibody for the C terminus of glutamate receptor subunit 2 (GluR2) and GluR3 (GluR2/3) rather than by an antibody for GluR4...
  14. ncbi Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitry
    Yun Guan
    Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
    Pain 104:401-13. 2003
    ..We analyzed mRNA and protein levels of the GluR1 and GluR2 AMPA receptor subunits in the RVM at 2h to 14 days post-inflammation...
  15. ncbi Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Eur J Neurosci 19:2017-29. 2004
    ..Most AMPA receptors are impermeable to calcium because they contain the GluR2 subunit...
  16. ncbi Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber CA3 pyramid synapses
    Michelle T W Ho
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:11651-62. 2007
    ..Concerning AMPA receptors (AMPARs), glutamate receptor 2 subunit (GluR2)-containing, Ca2+-impermeable AMPARs (CI-AMPARs) prevail at synapses between mature ..
  17. doi Flip and flop: a molecular determinant for AMPA receptor channel opening
    Weimin Pei
    Department of Chemistry, Center for Neuroscience Research, University at Albany, State University of New York, Albany, New York 12222, USA
    Biochemistry 48:3767-77. 2009
    ..e., flip and flop. The flop variant of the GluR2 AMPA receptor is known to desensitize faster than the flip counterpart, whereas the GluR1 flip and flop variants ..
  18. ncbi Ethanol sensitivity of recombinant homomeric and heteromeric AMPA receptor subunits expressed in Xenopus oocytes
    B Emmanuel Akinshola
    Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059, USA
    Alcohol Clin Exp Res 27:1876-83. 2003
    ..In this study, we compared ethanol sensitivity of homomeric and heteromeric AMPA receptor subunits microinjected into Xenopus oocytes and confirmed subunit expression in oocytes by immunoblot...
  19. ncbi Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice
    Andy N Mead
    Department of Psychology, School of Life Sciences, University of Sussex, BN1 9QG, UK
    Psychopharmacology (Berl) 179:164-71. 2005
    ..Critically, this classical conditioning procedure requires the formation of associations between a rewarding stimulus and environmental cues, and the ability of these cues to direct subsequent behaviour...
  20. ncbi Kainate-induced epilepsy alters protein expression of AMPA receptor subunits GluR1, GluR2 and AMPA receptor binding protein in the rat hippocampus
    C Sommer
    Department of Neuropathology, Ruprecht Karls University Heidelberg, Germany
    Acta Neuropathol 101:460-8. 2001
    ..through newly synthesized alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) receptors lacking the GluR2 subunit, which normally renders AMPA receptors calcium impermeable, is thought to play a pivotal role for ..
  21. ncbi The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 32:793-802. 2007
    ..profile, namely lamotrigine and riluzole, significantly enhanced the surface expression of GluR1 and GluR2 in a time- and dose-dependent manner in cultured hippocampal neurons...
  22. ncbi Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice
    Andy N Mead
    Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
    J Neurosci 23:9500-7. 2003
    Presence of the glutamate receptor 2 (GluR2) subunit prevents calcium influx through AMPA-receptor complexes; deletion of this subunit results in enhanced hippocampal long-term potentiation...
  23. ncbi The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits
    K K Dev
    Department of Biological Sciences, Kyoto University, Faculty of Medicine, Japan
    Neuropharmacology 38:635-44. 1999
    ..and the mutation of a single amino acid in this region (Lys-27 to Glu) prevents interaction between PICK1 and GluR2 in the yeast two-hybrid assay...
  24. ncbi Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons
    Michel Eybalin
    INSERM U583, Institut des Neurosciences, Hopital St Eloi, 80, avenue Augustin Fliche, BP 74103, 34091 Montpellier Cedex 5, France
    Eur J Neurosci 20:2981-9. 2004
    ..Here, we report that AMPA receptors at inner hair cell (IHC) synapses lack the GluR2 subunit and are transiently Ca2+-permeable before hearing onset as evidenced using agonist-induced Co2+ ..
  25. ncbi Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF
    Stephanie M Gardner
    Department of Neuroscience, Johns Hopkins University, School of Medicine, Howard Hughes Medical Institute, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Neuron 45:903-15. 2005
    ..Since the AMPA receptor GluR2 subunit confers calcium permeability, this plasticity is thought to occur through the dynamic exchange of synaptic ..
  26. ncbi Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes
    Joshua B Silverman
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:8505-16. 2007
    ..ABP) and the related glutamate receptor (GluR)-interacting protein (GRIP), two multi-PDZ proteins that bind the GluR2 and GluR3 AMPAR subunits. The resulting cadherin-NPRAP-ABP/GRIP complexes serve as anchorages for AMPARs...
  27. ncbi [ALS and excitatory amino acid]
    Hitoshi Aizawa
    Division of Neurology, Department of Internal Medicine, Asahik awa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Brain Nerve 59:1117-27. 2007
    ..mechanisms to increase Ca2+ influx through Ca2+-permiable AMPA receptor: a decrease of RNA editing efficacy at the GluR2 Q/R site and a decrease of GluR2 level relative to AMPA receptor subunits...
  28. doi Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure
    Xiu Sun
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Eur J Neurosci 30:539-50. 2009
    ..an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels...
  29. pmc Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs
    Cameron H Good
    Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 30:7900-9. 2010
    ..Using a unique rat brain slice preparation, we found that PPN stimulation activates afferents targeting GluR2-containing AMPA receptors (AMPAR) on VTA DA neurons, and these afferents did not exhibit long-term depression (LTD)..
  30. doi A subpopulation of serotonin 1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus
    C J Peddie
    Department of Life Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    Neurosci Lett 485:251-5. 2010
    ..study, we have examined the cellular and subcellular distribution of 5-HT(1B)Rs with the AMPA receptor subunit GluR2. Of 5-HT(1B)R positive profiles, 28% displayed colocalization with GluR2...
  31. pmc Peripheral AMPA receptors contribute to muscle nociception and c-fos activation
    Yang Hyun Chun
    Kyung Hee University, School of Dentistry, Department of Oral Medicine, 1 Hoegi dong, Dongdaemun Gu, Seoul, Republic of Korea
    Neurosci Res 62:97-104. 2008
    ..AMPA receptor subunits, GluR1 and GluR2, were predominantly expressed in small to medium size neurons but more GluR2 positive labeling were encountered in ..
  32. ncbi Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters
    Sunita DeSouza
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 22:3493-503. 2002
    ..postsynaptic density 95/Discs large/zona occludens 1) proteins that interact with glutamate receptors 2 and 3 (GluR2 and GluR3) subunits...
  33. doi AMPA receptor subunit-specific regulation by a distinct family of type II TARPs
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 59:986-96. 2008
    ..Here, we classify gamma-5 as a distinct class of TARP that modulates specific GluR2-containing AMPA receptors and displays properties entirely dissimilar from canonical TARPs...
  34. ncbi Ischemia-induced changes of AMPA-type glutamate receptor subunit expression pattern in the rat retina: a real-time quantitative PCR study
    Frederike Dijk
    Netherlands Ophthalmic Research Institute KNAW, Glaucoma Research Group, Graduate School for the Neurosciences Amsterdam, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 45:330-41. 2004
    ..Furthermore, to study possible changes in the ratios of alternative splice variants of GluR2 and -4 and possible changes in the subunit composition of the receptor complex after ischemia-reperfusion...
  35. ncbi Response of Purkinje neurons to hypobaric hypoxic exposure as shown by alteration in expression of glutamate receptors, nitric oxide synthases and calcium binding proteins
    C Kaur
    Department of Anatomy, Faculty of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597
    Neuroscience 135:1217-29. 2005
    ..glutamate receptors N-methyl-d-aspartate receptor subunit 1, amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid GluR2/3, calcium binding proteins and nitric oxide synthases in the Purkinje neurons was examined in rats exposed to ..
  36. ncbi Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus
    F R Tang
    Epilepsy Research Laboratories, National Neuroscience Institute, Singapore
    Epilepsy Res 59:167-80. 2004
    A comparative study of the expression of metabotropic glutamate receptor 2/3 (mGluR2/3) was done in the hippocampus of rats and mice after pilocarpine-induced status epilepticus (APISE), and of patients with mesial temporal lobe epilepsy...
  37. pmc Control of glutamate receptor 2 (GluR2) translational initiation by its alternative 3' untranslated regions
    Hasan A Irier
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Room 5002, 1510 Clifton Rd NE, Atlanta, GA 30322, USA
    Mol Pharmacol 76:1145-9. 2009
    Four major glutamate receptor 2 (GluR2) transcripts differing in size (approximately 4 and approximately 6 kilobases) due to alternative 3' untranslated regions (UTRs), and also containing alternative 5'UTRs, exist in the brain...
  38. ncbi Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction
    Michael C Hanna
    The National Institute of Neurological Disorders and Stroke, National Institutes of Health, Cellular Neurology Unit, Bethesda, MD, USA
    Mol Vis 13:2194-208. 2007
    ..Here we apply the same protocol to compare expression of these genes in cDNA constructed from single rod and cone bipolar cells previously-labeled for morphological identification in fixed slices of macaque retina...
  39. doi Differential response of AMPA and NMDA glutamate receptors of Purkinje cells to aging of the chicken cerebellum
    Raquel S Pires
    City University of Sao Paulo, Sao Paulo, Brazil
    Neurosci Lett 478:146-9. 2010
    ..4 years old) chickens (Gallus gallus) were used in order to evaluate the expression of GluR1, GluR2/3 and NR1 subunits...
  40. ncbi Localization of ionotropic and metabotropic glutamate receptors in distinct neuronal elements of the rat substantia nigra
    K K Yung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, China
    Neurochem Int 33:313-26. 1998
    ..was performed using commercially available antibodies (against subunits of ionotropic glutamate receptors: GluR1, GluR2/3, GluR4, NMDAR1, NMDAR2A/B; and subtypes of metabotropic glutamate receptors: mGluR1alpha, mGluR2/3)...
  41. ncbi Expression of the AMPA-selective receptor subunits in the vestibular nuclei of the chinchilla
    P Popper
    Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90024 1624, USA
    Brain Res Mol Brain Res 44:21-30. 1997
    ..were used to localize the messenger RNAs and proteins of the AMPA-selective receptor subunits GluR1, GluR2, GluR3 and GluR4 in the vestibular nuclei of the chinchilla...
  42. pmc Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Eur J Pharmacol 639:67-80. 2010
    ..We examined how the metabotropic glutamate receptor 2/3 agonist LY379268 and the metabotropic glutamate receptor 2/3 antagonist LY341495 altered phencyclidine-..
  43. ncbi Distribution of glutamate and preproenkephalin messenger RNAs following transient focal cerebral ischemia
    L K Friedman
    Department of Neuroscience, Seton Hall University NJ Neuroscience Institute, JFK Medical Center, Edison 08818, USA
    Neuroscience 95:841-57. 2000
    ..ischemia, in situ hybridization histochemistry was used to measure levels of glutamate receptor subunit 1 (GluR1), GluR2, GluR3, N-methyl-D-aspartate receptor subunit 1 (NR1) and preproenkephalin messenger RNAs in adult rats at various ..
  44. ncbi Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses
    Wataru Kakegawa
    Department of Neurophysiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Eur J Neurosci 20:101-10. 2004
    ..To trace the subunit-specific trafficking of AMPARs at each synapse, GluR1 and GluR2 subunits were introduced into CA3 pyramidal neurons in hippocampal organotypic cultures using the Sindbis viral ..
  45. ncbi Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb
    A A Montague
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 405:233-46. 1999
    ..by using antibodies to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunits: GluR1, GluR2/3, and GluR4; and kainate (KA) receptor subunits: GluR5/6/7...
  46. ncbi GluR2/3, NMDAepsilon1 and GABAA receptors in Creutzfeldt-Jakob disease
    I Ferrer
    Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907, Hospitalet de Llobregat, Spain
    Acta Neuropathol 106:311-8. 2003
    ..Glutamate receptors AMPA GluR2/3 and NMDA R2A: NR2A (NMDAepsilon1), and GABA(A) (GABA(A) Ralpha1) receptors were examined by immunohistochemistry ..
  47. ncbi Glutamate receptor subunits GluR1 and GluR2/3 distribution shows reorganization in the human epileptogenic hippocampus
    N C de Lanerolle
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Eur J Neurosci 10:1687-703. 1998
    The AMPA-type glutamate receptor subunits GluR1 and GluR2/3 were localized by immunohistochemistry with subunit-specific antibodies in hippocampi removed surgically from patients with temporal lobe epilepsy for the control of seizures...
  48. ncbi Ischemia and ischemic tolerance induction differentially regulate protein expression of GluR1, GluR2, and AMPA receptor binding protein in the gerbil hippocampus: GluR2 (GluR-B) reduction does not predict neuronal death
    Clemens Sommer
    Department of Neuropathology, Ruprecht Karls University of Heidelberg, Germany
    Stroke 33:1093-100. 2002
    ..of calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors lacking the GluR2 subunit (GluR2 hypothesis). DND can be prevented by a short tolerance-inducing ischemic period...
  49. ncbi GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity
    P Van Damme
    Laboratory for Neurobiology, University of Leuven, B 3000 Leuven, Belgium
    J Neurophysiol 88:1279-87. 2002
    ..Because the absence of GluR2 in AMPA receptors renders them highly permeable to Ca(2+) ions, it has been hypothesized that the selective ..
  50. pmc eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons
    Andon N Placzek
    Department of Neuroscience, Baylor College of Medicine, Houston, United States
    elife 5:. 2016
    ..This persistent LTP is mediated by the insertion of GluR2-lacking AMPARs...
  51. ncbi Cellular, subcellular, and subsynaptic distribution of AMPA-type glutamate receptor subunits in the neostriatum of the rat
    V Bernard
    University Department of Pharmacology, Oxford University, United Kingdom
    J Neurosci 17:819-33. 1997
    ..neostriatum, we applied multiple immunocytochemical techniques using anti-peptide antibodies against the GluR1, GluR2/3, and GluR4 subunits at both the light and electron microscopic levels...
  52. ncbi Subcellular distribution of AMPA and NMDA receptor subunit immunoreactivity in ventral posterior and reticular nuclei of rat and cat thalamus
    X B Liu
    Department of Anatomy and Neurobiology, University of California, Irvine 92682, USA
    J Comp Neurol 388:587-602. 1997
    ..The authors used electron microscopic immunocytochemistry to localize AMPA selective GluR 2/3 subunits (GluR2/3) and NMDA receptor subunit 1 (NMDAR1) in rat and cat ventral posterior lateral nucleus (VPL) ..
  53. ncbi Plasticity in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunits in the rat dorsal horn following deafferentation
    S M Carlton
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Neurosci Lett 242:21-4. 1998
    Immunostaining for GluR1 and GluR2/3 subunits of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is prominent in laminae I and II of the normal dorsal horn, with much less staining in deeper laminae...
  54. ncbi Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
    J W Lin
    Howard Hughes Medical Institute, Massachusetts General Hospital Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 3:1282-90. 2000
    ..dependent on protein phosphatases and sequence determinants within the cytoplasmic tails of GluR1 and GluR2 subunits...
  55. ncbi Regulation of AMPA receptor lateral movements
    Aren J Borgdorff
    CNRS UMR 5091, Universite de Bordeaux 2, Bordeaux 33077, France
    Nature 417:649-53. 2002
    ..We analysed the lateral mobility of native AMPA receptors containing the glutamate receptor subunit GluR2 in rat cultured hippocampal neurons, using single-particle tracking and video microscopy...
  56. pmc Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD
    Pascal Steiner
    Faculté des Sciences de la Vie, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    J Cell Biol 157:1197-209. 2002
    ..N-methyl-d-aspartate (NMDA) stimulation, the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunit GluR2 is internalized into NEEP21-positive endosomes...
  57. ncbi Glutamate receptors at bipolar synapses in the inner plexiform layer of primate retina: light microscopic analysis
    Ulrike Grünert
    Department of Physiology F13 and Institute for Biomedical Research, The University of Sydney, NSW 2006, Australia
    J Comp Neurol 466:136-47. 2003
    ..For all bipolar cell types, immunoreactive puncta for the AMPA receptor subunits GluR2, 2/3, and 4 were colocalized at highest densities, whereas GluR1-immunoreactive puncta were expressed at very low ..
  58. pmc Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD
    Gholamreza Ahmadian
    National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran
    EMBO J 23:1040-50. 2004
    ..In HEK293 cells transiently expressing GluR1 or GluR2 mutants containing domain deletions or point mutations in their intracellular carboxyl termini (CT), we found that ..
  59. ncbi Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons
    Fumio Ogoshi
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 193:384-93. 2005
    ..6 nM, 15 min) induced a rapid increase in cell surface levels not only of GluR1, but also of the AMPAR subunit GluR2, on most neurons, without evident new protein synthesis...
  60. pmc Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors
    Derya R Shimshek
    Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    PLoS Biol 3:e354. 2005
    ..Thus, correlated differences in behavior and levels of GluR-B expression allowed a mechanistic and spatial dissection of olfactory learning, discrimination, and memory capabilities...
  61. pmc Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurochem 95:1785-93. 2005
    ..9 +/- 4.6 mg/kg. Statistically significant elevations were observed for NR1, GluR1, GluR2/3 and GluR5 (p < 0.05) and a trend towards increased NR1 phosphorylated at serine 896 (p = 0...
  62. ncbi Maturational changes in the subunit composition of AMPA receptors and the functional consequences of their activation in chicken forebrain
    Paola V Migues
    School of Biomedical Sciences and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia
    Dev Neurosci 29:232-40. 2007
    ..We found that during maturation the relative concentration of GluR2 subunits increased, the concentration of the AMPA receptor-associated scaffold proteins SAP97 and GRIP decreased ..
  63. doi Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm
    T B Tikhonova
    Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St Petersburg, Russia
    Neuropharmacology 54:653-64. 2008
    ..block of AMPA receptor (AMPAR) channels by a series of dicationic compounds was studied on native GluR2-lacking receptors of striatal giant interneurons isolated from rat brain slices...
  64. doi The fast kinetics of AMPA GluR3 receptors is selectively modulated by the TARPs gamma 4 and gamma 8
    Erika Suzuki
    Department of Pharmacology, Southern Illinois University School of Medicine, 801 North Rutledge Street, PO Box 19629, Springfield, Illinois 62794 9629, USA
    Mol Cell Neurosci 38:117-23. 2008
    ..This stands in contrast to the effects on GluR1 and GluR2 receptors which were similar across all four TARPs...
  65. pmc Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
    Christopher P Ptak
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 48:8594-602. 2009
    ..bind to the pocket bridging the dimer interface, we generated a series of crystal structures of the GluR2 ligand-binding domain complexed with benzothiadiazide derivatives (IDRA-21, hydroflumethiazide, ..
  66. pmc Integrins modulate relapse to cocaine-seeking
    Armina Wiggins
    Department of Neurosciences, Medical University of South Carolina, Charleston 29425, USA
    J Neurosci 31:16177-84. 2011
    ..Finally, reduced surface expression of the GluR2 subunit of the AMPA receptor is associated with cocaine-seeking, and daily RGD microinjections during self-..
  67. doi Long-term neuropeptide Y administration in the periphery induces abnormal baroreflex sensitivity and obesity in rats
    Fang Xie
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratory of Biomedicine Pharmaceutics of China, Harbin, China
    Cell Physiol Biochem 29:111-20. 2012
    ..to the decreases in MABP induced by sodium nitroprusside; (2) decreased protein levels of substance P (SP) and GluR2, while increased the expression of γ-aminobutyric acid A receptor (GABA(A)R) in brainstem; (3) abdominal obesity ..
  68. pmc Long-term memory search across the visual brain
    Milan Fedurco
    Michelin Recherche Technique, S A, Route André Piller 30, 1762 Givisiez, Fribourg, Switzerland
    Neural Plast 2012:392695. 2012
    ..Maintenance of the visual long-term memories is suggested to require recycling of GluR2-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) and β(2)-adrenoreceptors at ..
  69. ncbi Glutamate receptors in human caudate nucleus in normal aging and Alzheimer's disease
    Konstantinos I Tsamis
    Department of Neurology, School of Medicine, University of Ioannina, 45500 Ioannina, Greece
    Curr Alzheimer Res 10:469-75. 2013
    ..receptor subunit 1 (NMDAR1), α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit 2 (GluR2) and metabotropic glutamate receptor 5 (mGluR5)...
  70. pmc AMPA and GABA(A/B) receptor subunit expression in the cuneate nucleus of adult squirrel monkeys during peripheral nerve regeneration
    Todd M Mowery
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States Electronic address
    Neurosci Lett 559:141-6. 2014
    ..That is, the expression of GluR2/3 AMPA receptor subunits is significantly increased, while GABA α1 and GABABR1b receptor subunits are ..
  71. doi KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling
    Neus Pedraza
    Molecular Biology Institute of Barcelona IBMB CSIC, 08028 Barcelona, Catalonia, Spain and
    J Neurosci 34:13988-97. 2014
    ..decrease of protein levels of PSD-95, a postsynaptic scaffolding protein, and the AMPAR subunits GluR1 and GluR2 in a CPEB3-dependent manner...
  72. pmc Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages
    Judy Choi
    a Johannes Gutenberg University of Mainz Mainz, Germany
    Cancer Biol Ther 16:1205-13. 2015
    ..Quantitative real-time PCR analysis showed (i) significant increases in the expressions of GRIA2 (GluA2 or AMPA receptor 2), SLC1A2 (EAAT2), SLC1A3 (EAAT1), (ii) a near-significant decrease in the expression of SLC7A11 ..
  73. doi Molecular cloning, expression profiles and characterization of a glutathione reductase in Hevea brasiliensis
    Zhi Deng
    Key Laboratory of Biology and Genetic Resources of Rubber Tree, Ministry of Agriculture, Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan 571737, China Electronic address
    Plant Physiol Biochem 96:53-63. 2015
    ..In this study, a new GR gene, named as HbGR2, was isolated from Hevea brasiliensis...
  74. doi Toward a better understanding of the central consequences of intestinal inflammation
    Kewir D Nyuyki
    Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
    Ann N Y Acad Sci 1351:149-54. 2015
    ..in excitatory, AMPA receptor-mediated transmission, in part due to increased numbers of AMPA receptors lacking the GluR2 subunit...
  75. doi Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway
    Hongkun Bao
    State Key Laboratory for Conservation and Utilization of Bio Resources in Yunnan, Yunnan University, Kunming, Yunnan, PR China School of Medicine, Yunnan University, Kunming, Yunnan, PR China
    Behav Brain Res 317:263-271. 2017
    ..After 5days of treatment, LNT enhanced p-GluR1 (S845) in the prefrontal cortex (PFC); however, the total GluR1, GluR2, and GluR3 expression levels remained unchanged...
  76. ncbi Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain
    R J Wenthold
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:501-7. 1992
    ..antibodies were found to be selective for each of the four GluR subunits, and a fifth antibody recognized both GluR2 and 3...
  77. ncbi Antinociceptive effects and synergistic interaction with morphine of intrathecal metabotropic glutamate receptor 2/3 antagonist in the formalin test of rats
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 8 Hakdong, Dongku, Gwangju 501 757, Korea
    Neurosci Lett 394:222-6. 2006
    ..LY341495 and morphine also showed synergistic drug interaction for antinociception during phase 2 in the formalin test...
  78. ncbi Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 26:2852-61. 2006
    ..Numerous crystallographic studies, the majority on the GluR2-subtype AMPA receptor, have revealed the structural basis for binding of subtype-specific agonists...
  79. pmc An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity
    Akira Terashima
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 57:872-82. 2008
    PICK1 is a calcium-sensing, PDZ domain-containing protein that interacts with GluR2 and GluR3 AMPA receptor (AMPAR) subunits and regulates their trafficking...
  80. pmc Purification and crystallization of a non-GluR2 AMPA-receptor ligand-binding domain: a case of cryo-incompatibility addressed by room-temperature data collection
    Avinash Gill
    Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:831-5. 2008
    ..This is the first non-GluR2 AMPA-R LBD available for structural analysis...
  81. doi PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking
    Paola Virginia Migues
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 13:630-4. 2010
    ..memory in rats and that the extent of the impairment was positively correlated with a decrease in postsynaptic GluR2. Blocking the GluR2-dependent removal of postsynaptic AMPA receptors abolished the behavioral impairment caused by ..
  82. pmc Input-specific critical periods for experience-dependent plasticity in layer 2/3 pyramidal neurons
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 31:4456-65. 2011
    ..Furthermore, plasticity at layer 2/3 inputs does not invoke the trafficking of calcium-permeable, GluR2-lacking AMPA receptors, whereas it sometimes does at layer 4 inputs...
  83. pmc Activation of {beta}-adrenergic receptors facilitates heterosynaptic translation-dependent long-term potentiation
    Steven A Connor
    Centre for Neuroscience, University of Alberta School of Medicine, Medical Sciences Building, Edmonton, Canada
    J Physiol 589:4321-40. 2011
    ..Conversely, the time window for inter-pathway transfer of heterosynaptic LTP was extended through inhibition of GluR2 endocytosis...
  84. doi Short-term, moderate exercise is capable of inducing structural, BDNF-independent hippocampal plasticity
    Ana F B Ferreira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Brain Res 1425:111-22. 2011
    ..SYP), neurofilaments (NF), microtubule-associated protein 2 (MAP2), glutamate receptor subunits GluR1 and GluR2/3, brain-derived neurotrophic factor (BDNF) and glial fibrillary acidic protein (GFAP)...
  85. ncbi GluR1-immunopositive interneurons in rat neocortex
    V N Kharazia
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599, USA
    J Comp Neurol 368:399-412. 1996
    ..suggest that inhibitory interneurons in cortex may express the GluR1 glutamate receptor subunit in the absence of GluR2, leading to calcium-permeable alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) channels...
  86. ncbi AMPA and NMDA glutamate receptor subunits in midbrain dopaminergic neurons in the squirrel monkey: an immunohistochemical and in situ hybridization study
    M Paquet
    Centre de Recherche en Neurobiologie, Hopital de l Enfant Jesus, Universite Laval, Quebec, Canada G1J 1Z4
    J Neurosci 17:1377-96. 1997
    ..substantia nigra compacta (SNc-v, SNc-d) and the ventral tegmental area (VTA) are immunoreactive for AMPA (GluR1, GluR2/3, and GluR4) and NMDAR1 receptor subunits, but not for NMDAR2A/B subunits...
  87. ncbi Adenovirus-mediated expression of AMPA-type glutamate receptor channels in PC12 cells
    M Sudo
    Department of Physiology, Gunma University School of Medicine, Gunma ken, Maebaeshi, Japan
    Brain Res Mol Brain Res 50:91-9. 1997
    ..They are composed of four subunits, GluR1, GluR2, GluR3 and/or GluR4...
  88. ncbi The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs
    P Osten
    Howard Hughes Medical Institute, Department of Biochemistry, NYU Medical Center, New York, New York 10016, USA
    Neuron 21:99-110. 1998
    In this study, we demonstrate specific interaction of the GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminal peptide with an ATPase N-ethylmaleimide-sensitive fusion protein (NSF) and alpha- and ..
  89. ncbi Subcellular and subsynaptic distribution of the NR1 subunit of the NMDA receptor in the neostriatum and globus pallidus of the rat: co-localization at synapses with the GluR2/3 subunit of the AMPA receptor
    V Bernard
    Anatomical Neuropharmacology Unit, University Department of Pharmacology, Oxford, UK
    Eur J Neurosci 10:3721-36. 1998
    ..and AMPA receptors, double labelling was performed with the NR1 antibodies and an antibody that recognizes the GluR2 and 3 subunits of the AMPA receptor...
  90. ncbi Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression
    Z F Mainen
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nat Neurosci 1:579-86. 1998
    ..To test these models directly, we studied a GluR2 knockout mouse in which AMPA receptor transmission is rendered sensitive to a use-dependent block by polyamine ..
  91. ncbi Effect of 6-hydroxydopamine or repeated amphetamine treatment on mesencephalic mRNA levels for AMPA glutamate receptor subunits in the rat
    M T Bardo
    Department of Psychology, University of Kentucky, Lexington, KY 40506, USA
    Neurosci Lett 302:133-6. 2001
    ..b>GluR2 levels were decreased 1 and 3 days after the lesion, and GluR1 and GluR3 levels also showed a transient decrease ..
  92. ncbi Getting a GRIP on liprins
    Renee Baran
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Neuron 34:1-2. 2002
    ..that mammalian liprin-alpha1 forms a complex with the PDZ protein GRIP and LAR in both pre- and postsynaptic compartments of hippocampal neurons and is required for the clustering of the GluR2 glutamate receptor in dendritic spines.
  93. ncbi Altered profile of gene expression in rat hearts induced by chronic nicotine consumption
    Dahai Hu
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
    Biochem Biophys Res Commun 297:729-36. 2002
    ..2, glutathione-S-transferase mu type 2, corticotropin-releasing factor receptor 2, metabotropic glutamate receptor 2, N-methyl-D-aspartate receptor subtype 2B, muscarinic acetylcholine receptor M3, transmembrane receptor ..
  94. ncbi Gene expression of AMPA-type glutamate receptor subunits in rod-type ON bipolar cells of rat retina
    Willem Kamphuis
    Graduate School for the Neurosciences Amsterdam, The Netherlands
    Eur J Neurosci 18:1085-92. 2003
    ..2003) J. Comp. Neurol., 455, 172-186] of mGluR6 with the ionotropic AMPA-type glutamate receptor subunit GluR2 in rod bipolar cells of rat retina...
  95. ncbi Cyclothiazide binding to functionally active AMPA receptor reveals genuine allosteric interaction with agonist binding sites
    Ilona Kovacs
    Department of Neurochemistry, Chemical Research Center, Hungarian Academy of Sciences, 1025 Pusztaszeri út 59 67, Budapest, Hungary
    Neurochem Int 44:271-80. 2004
    ..mechanics calculations of CTZ-induced structural changes were performed with the use of PDB data on extracellular GluR2 binding domain dimeric crystals available by now...
  96. ncbi Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction
    Elliott J Mufson
    Department of Neurological Sciences and Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Tech 2000, 2242 West Harrison St, Suite 200, Chicago, IL 60612, USA
    J Chem Neuroanat 26:233-42. 2003
    ..Studies using human autopsy material indicate an age-related dissociation of calbindin and the glutamate receptor GluR2 within CBF neurons, suggesting that these molecules act synergistically to induce excitotoxic cell death during ..
  97. ncbi Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2
    Anne Frandsen
    Biostructural Research, Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100, Copenhagen Ø, Denmark
    Mol Pharmacol 67:703-13. 2005
    ..The present study provides X-ray structures of the glutamate receptor 2 (GluR2)-selective partial agonist (S)-2-amino-3-(1,3,5,6,7-pentahydro-2,4-dioxocyclopenta[e] pyrimidin-1-yl)..
  98. ncbi Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus
    Olga Poisik
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Neuropharmacology 49:57-69. 2005
    ..Therefore, our findings do not only shed light on the functions of group II mGluRs in the GP, they also illustrate the therapeutic potential of mGluR-targeting allosteric modulators in neurological disorders such as Parkinson's disease...
  99. ncbi The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209
    Christina Kasper
    Biostructural Research Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Mol Biol 357:1184-201. 2006
    ..We present here the first X-ray structure of a mixed GluR2 ligand-binding core dimer, with the high-affinity antagonist (S)-8-methyl-5-(4-(N,N-dimethylsulfamoyl)phenyl)-6,7,..
  100. ncbi Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites
    Baosong Liu
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:5309-19. 2006
    ..Ischemic insults promote internalization of glutamate receptor subunit 2 (GluR2)-containing AMPARs from synaptic sites via clathrin-dependent endocytosis and facilitate delivery of GluR2-lacking ..
  101. ncbi Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders
    Monica Beneyto
    Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 32:1888-902. 2007
    ..In the entorhinal cortex, most changes in glutamate receptor expression were associated with BD, with decreased GluR2, GluR3, and GluR6 mRNA expression...

Research Grants63

  1. Characterizing an AMPA Receptor Splice Modulator in Preventing Epileptogenesis
    Melanie K Tallent; Fiscal Year: 2012
    ..In hippocampal and cortical pyramidal neurons, AMPA receptors are comprised largely of GluR1/GluR2 and GluR2/GluR3 heteromeric tetramers...
  2. Regulation of calcium-permeable AMPA receptors in associative memory
    ROGER LEE CLEM; Fiscal Year: 2012
    ..AMPARs that lack the GluR2 subunit are commonly referred to as calcium- permeable AMPARs (CP-AMPARs) due to their unique conductance ..
  3. Steven J Tavalin; Fiscal Year: 2015
    ..AMPARs tend to be preferentially assembled in heteromeric complexes composed of GluA1 and GluA2 subunits...
  4. Anatomy of postsynaptic plasticity in hippocampus
    Richard J Weinberg; Fiscal Year: 2012
    ..Excitatory synapses in hippocampus express AMPARs comprising GluR1, GluR2, and GluR3 subunits;GluR2 and GluR3 are trafficked and anchored at the synapse by the same mechanisms, distinct ..
  5. AMYGDALA AMPA GLUR2 DELETION AND OPIOID DEPENDENCE
    Michael J Glass; Fiscal Year: 2010
    ..The AMPA-GluR2 (GluR2) receptor subunit is a major component of AMPA receptors, determines calcium permeability, has been ..
  6. GLUTAMATE RECEPTORS AND OPIOID DEPENDENCE: MOLECULES, CIRCUITS AND BEHAVIOR
    Michael J Glass; Fiscal Year: 2013
    ..Aim 3 will test the hypothesis that acute opioid exposure can affect the trafficking of the AMPA-GluR2 receptor subunit at postsynaptic sites in CeA neurons, a process that can be inhibited by local NR1 gene deletion...
  7. Terunaga Nakagawa; Fiscal Year: 2014
    ..which are critical for understanding synaptic plasticity, we propose to compare the 3D EM structure of the mature GluR2 tetramer with those of dimeric biosynthetic intermediates...
  8. Allosteric Modulators of Glutamate Receptors
    Robert E Oswald; Fiscal Year: 2010
    ..We have determined the crystal structure of one AMPA receptor-binding domain (GluR2 S1S2) with six different allosteric activators and studied some of the complexes using NMR spectroscopy...
  9. Defining the epitope in anti-AMPA receptor encephalitis
    DAVID ROBINSON LYNCH; Fiscal Year: 2013
    ..Patients with this syndrome make antibodies to the extracellular portion of the AMPAR subunits GluR1 and/or GluR2. Our new preliminary data have identified structural determinants in the amino terminal domain (ATD) of GluR1/2 ..
  10. Role of AMPA receptors in the nucleus accumbens shell in morphine depedence
    Elena Chartoff; Fiscal Year: 2009
    ..2005). Prior work has demonstrated that elevating GluR1 levels in the NASh decreases, and GluR2 increases, the rewarding effects of cocaine and lateral hypothalamic brain stimulation (Kelz et al...
  11. Roberto Dominguez; Fiscal Year: 2016
    ..Full-length PICK1 was crystallized with bound Ca2+ and the GluR2 AMPA receptor tail. The structure of the BAR domain of PInB is nearly finished...
  12. Robert E Oswald; Fiscal Year: 2016
    ..previous granting period, backbone and sidechain dynamics were studied with a series of partial agonists bound to GluR2 S1S2 using NMR spectroscopy...
  13. AMPA Receptor Trafficking and Signaling Complexes
    Edward B Ziff; Fiscal Year: 2010
    We will study the mechanism of trafficking of the GluR2 subunit of the AMPA receptor to synapses in cultured hippocampal neurons...
  14. Regulation and Neural Function of Atypical PKC
    Todd C Sacktor; Fiscal Year: 2011
    ..strength by increasing the number of postsynaptic AMPA receptors (AMPARs) through interactions between the AMPAR GluR2 subunit and the trafficking protein NSF...
  15. Molecular Mechanisms of Cocaine-Induced Alterations in Accumbens AMPA Receptors
    Rachel J Smith; Fiscal Year: 2012
    ..integrin was identified as playing a key role in maintaining surface expression of AMPA receptors containing the GluR2 subunit...
  16. Roh Yu Shen; Fiscal Year: 2015
    ..leads to a rectification of AMPA receptor-mediated current, suggesting an increased expression of high conductance GluR2 subunit-lacking AMPA receptors...
  17. Todd C Sacktor; Fiscal Year: 2016
    ..strength by increasing the number of postsynaptic AMPA receptors (AMPARs) through interactions between the AMPAR GluR2 subunit and the trafficking protein NSF...
  18. Neurochemical and metabolic regulation in the visual cortex
    MARGARET TT WONG-RILEY; Fiscal Year: 2013
    ..They will also provide the basis for future gene therapy for visual deficits resulting from faulty energy metabolism. ..
  19. Calcium Permeable AMPA Receptors: Signaling, Toxicity and Control
    Edward B Ziff; Fiscal Year: 2013
    ..b>GluR2 when modified by RNA editing dominantly blocks the Ca2+ conductance of AMPAR channels...
  20. The Role of GluR2-dependent Synaptic Scaling in Development and Plasticity
    MELANIE GAINEY; Fiscal Year: 2010
    ..can be blocked in single cultured cortical neurons with an RNAi hairpin that targets the AMPA receptor subunit, GluR2, suggesting that GluR2 is critical for expression of scaling...
  21. The maintenance of fear memories in the amygdala
    RYAN PARSONS; Fiscal Year: 2012
    ..also test the hypothesis that the maintenance of fear memory in the amygdala is supported by the trafficking of GluR2 containing 1-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors, which is thought to be controlled ..
  22. Jaideep Kapur; Fiscal Year: 2014
    ..In biochemical analysis GluR2 subunit surface expression was reduced compared in SE-treated animals to that in control animals...
  23. CARLOS A JIMENEZ-RIVERA; Fiscal Year: 2016
    ..peptide Tat-GluR23y and rectification index curves in whole cell patch recordings to examine the contribution of GluR2-dependent and GluR2-lacking AMPA receptors in maintaining PKM? effects in cocaine sensitization...
  24. Role of AMPA Receptor Reverse Signaling in Synapse Stability
    Anirvan Ghosh; Fiscal Year: 2012
    ..We have identified LRRTM2 as a GluR2-interacting transmembrane protein that affects synapse stability...
  25. CENTER FOR NEUROSCIENCE EXCELLENCE
    Rodney L Parsons; Fiscal Year: 2010
    ..Miguel Martin-Caraballo: Developmental regulation of GluR2 AMPA receptor subunit expression, 3) Dr. Jeffrey Spees: Adult Bone Marrow Stem Cells For CMS Repair, and 4) Dr...
  26. Anna Kalinchuk; Fiscal Year: 2016
    ..We will infuse iNOS inhibitor or A1R antagonist to the PFC/FC during SD and measure the changes in GluR1 and GluR2 phosphorylation. Our PD show that iNOS blocking reverses SD-induced effects. SA4...
  27. Athina Markou; Fiscal Year: 2014
    ..Aim 3 will assess the effects of viral-vector mediated increased expression of AMPA receptor subunits (GluR1 and GluR2) in the NAcc core and shell on extinction training and subsequent cue-induced reinstatement of nicotine seeking...
  28. NEUROPATHOLOGY AND PATHOGENESIS OF HUNTINGTON' DISEASE
    Anton Reiner; Fiscal Year: 2004
    ..2) A preponderance of GluR2 containing AMPARs in striatal neurons projecting to the internal pallidal segment accounts for their lesser ..
  29. PKC-dependent GluR2 internalization in the spinal cord by persistent pain
    Yuan Xiang Tao; Fiscal Year: 2009
    ..AMPA receptor GluR2 subunit, through its binding to GRIP and PICK1, may function in the synaptic AMPA receptor trafficking that is ..
  30. RNA editing of AMPA receptor subunit GluR2 in ischemia
    YouMing Lu; Fiscal Year: 2010
    ..Ca2+ permeability of the channels is dominated by GluR2 RNA editing at the Q/R site;edited GluR2(R) subunits form Ca2+-impermeable channels, whereas unedited GluR2(Q) ..
  31. The Role of AMPA Receptors with Q/R-Unedited GluR2 in Neurogenesis
    Nicholas Whitney; Fiscal Year: 2009
    ..We have found that human NPC express calcium-permeable AMPA receptors containing Q/R-unedited GluR2 subunits;whereas, NPC differentiated to neurons and astrocytes express calcium-impermeable AMPA receptors ..
  32. Control of AMPAR Trafficking by NMDAR-Mediated PKD1 Translocation
    EVA S LADOW; Fiscal Year: 2010
    ..Specific Aim 1. Elucidate the mechanisms by which PKD1 regulates GluR2 trafficking. Specific Aim 2. Characterize the functional significance of PKD1 regulation of GluR2 trafficking...
  33. Richard A Morrisett; Fiscal Year: 2015
    ..In aim 2, we will determine whether interference with GluR2 internalization alters operant self-administration behavior in mice...
  34. Tsung Ung W Woo; Fiscal Year: 2014
    ..other glutamate receptor subunits, including the AMPA (1-amino- 3-hydroxyl-5-methyl-4-isoxazole-propionate) GluR2 subunit and the metabotropic group I glutamate receptor mGluR1 or 5 subunit, or the dopamine D1 receptor may ..
  35. Role of CREST in cortical development and plasticity
    Massimo Scanziani; Fiscal Year: 2013
    ..The goals of the project are: (i) To examine the role of CREST in activity-dependent down-regulation of GluR2 expression;(ii) To examine the role CREST in activity-dependent regulation of NR2B expression;(iii) To examine the ..
  36. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2012
    ..The role of Kal7 in spine formation in response to proteins such as Shank3, GluR2 and Neuroligin-1 will be assessed...
  37. Glutamate-Dopamine Plasticity in Nigrostriatal Injury: Excerise Enhanced Recovery
    John P Walsh; Fiscal Year: 2010
    ..medium spiny neurons indicated altered glutamatergic neurotransmission specifically increased expression of GluR2 subunits, an important member of the AMPA subtype of glutamate receptor...
  38. Functional Characterization of synaptic calcium/calmodulin kinase II (CaMKII) acc
    Jacqueline K Rose; Fiscal Year: 2010
    ..As well, investigation into expression levels of other synaptic proteins (e.g., GluR2, and NMDA receptor subunits) following L-IPS translocation of CaMKII will be conducted...
  39. Mechanisms of feedback from retinal horizontal to cone cells
    Tzu Ming Wang; Fiscal Year: 2013
    ..To examine the importance of HC calcium influx in initiating this feedback, transgenic zebrafish expressing GluR2 in HCs have been created...
  40. John C Gore; Fiscal Year: 2014
    ..We will correlate the imaging findings with treatment effects on cognition tasks. Normalization of resting state brain fluctuations may be an important biomarker of the therapeutic efficacy of antipsychotic agents. ..
  41. Paul J Lombroso; Fiscal Year: 2014
    ..Over the last cycle, we have discovered that STEP also induces NR1/NR2B and GluR1/GluR2 internalization...
  42. Richard A Morrisett; Fiscal Year: 2014
    ..Furthermore, disruption of the processes underlying the changes in glutamate receptor location and function (GluR2 subunit internalization) modulates behavioral responses to such reinforcers...
  43. Structure, function and dynamics of a glutamate receptor
    Robert Oswald; Fiscal Year: 2009
    ..The crystal structure of the S1S2 domain of the GluR2 subunit has been solved by E. Gouaux and collaborators...
  44. Distinct role of Neurabin and Spinophilin in Synaptic Transmission and Plasticity
    Houhui Xia; Fiscal Year: 2013
    ..e, Ser657 on PKC[unreadable] (and indirectly on Ser880 on GluR2) and Ser831 on GluR1, respectively...
  45. Impact of early life seizures on glutamate receptors and synaptic function
    Timothy Benke; Fiscal Year: 2009
    ..Contrary to prior biochemical studies suggesting isolated down-regulation of GluR2, our electrophysiological data suggests synaptic GluR1 is transiently up-regulated shortly after ELS but later ..
  46. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy B Macklin; Fiscal Year: 2013
    ..We will analyze Plp-null, v integrin null and GluR2-null mice, after crossing our Plp-Enhanced Green Fluorescent Protein (EGFP) transgene into them...
  47. PKC-Dependent Spinal GluR2 Internalization Triggered by NMDARs in Chronic Pain
    Yuan Xiang Tao; Fiscal Year: 2010
    ..The AMPA receptor GluR2 subunit, through its binding to GRIP and PICK1, may function in the synaptic AMPA receptor trafficking that is ..
  48. GENE EXPRESSION IN SINGLE AGING NEURONS AND GLIA
    James H Eberwine; Fiscal Year: 2010
    ..bind to three RNAs that are targeted to and differentially translated in neuronal dendrites, those that encode the GluR2, GluR4 and the NMDA-R1 receptor subunit proteins...
  49. IVAN JULIAN DMOCHOWSKI; Fiscal Year: 2016
    ..will be tested and optimized in leukemia cells (against c-myb), zebrafish (against chordin), and neurons (against GluR2). Several additional genes, including GFP, will be upregulated as proof-of-concept in these biological systems...
  50. SYNAPTIC HOMEOSTASIS IN NEOCORTICAL NEURONS
    Gina G Turrigiano; Fiscal Year: 2013
    ..Recently we found that synaptic scaling up is transcription-dependent, and requires the GluR2 subunit of the AMPAR for its expression, indicating that transcription of a factor or factors results in enhanced ..
  51. Siqiong June Liu; Fiscal Year: 2016
    ..We have recently shown that noradrenaline released during an acute olfactory stress in mice promotes GluR2 gene transcription and alters excitatory synaptic transmission onto cerebellar inhibitory interneurons...
  52. Markers of olfactory neurotransmission in Schizophrenia
    Lise Rioux; Fiscal Year: 2004
    ..with T7 polymerase (IDAT) to investigate a shift in subunit composition away from NMDAR2 B subtype and toward gluR2 subtype...
  53. NMDA RECEPTOR--AGONIST AFFINITY, EFFICACY/TRANSDUCTION
    Antonius VanDongen; Fiscal Year: 2004
    ..The recently published crystal structure of the ligand binding domains of a related glutamate receptor (GluR2) predicts which amino acids are in direct contact with the agonists...
  54. Preclinical Evaluation of GluR2-3Y Peptide as a Potential New Medication for Poly
    Yu Tian Wang; Fiscal Year: 2013
    ....
  55. THE MECHANISM AND FUNCTION OF A TO I RNA EDITING
    Jinghua Yang; Fiscal Year: 2004
    ..The proposed experiments will provide fundamental information regarding the role of A-to-I pre-mRNA editing in mammalian gene expression and regulation that could be used to combat disease. ..
  56. Cochlear Nucleus Proteomics in a Mouse Model of Age-Related Hearing Loss
    Xian Chen; Fiscal Year: 2007
    ..protein that changed during AHL progression based on our electrophysiological data -- the ionotropic glutamate receptor 2. Since isoform variation and posttranslational modification of this protein is known to affect its activity,..
  57. EAA RECEPTOR PLASTICITY AFTER SPINAL CORD CONTUSION
    JEAN WRATHALL; Fiscal Year: 2002
    ..We will focus on injury-induced alterations in the GluR2 subunit which regulates the calcium permeability of alpha- amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (..
  58. Limbic-cortical involvement in drug seeking
    Janet Neisewander; Fiscal Year: 2006
    ..D1, D2, or D3 receptors, 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT4 receptors, and glutamate AMPA receptor subunits GluRl, GluR2, and GluR3 using double-labeling in situ hybridization...
  59. BIOBEHAVIORAL MECHANISMS OF DRUG REWARD AND ADDICTION
    WILLIAM CARLEZON; Fiscal Year: 2009
    ..In Aim 2, we will use viral-mediated gene transfer to selectively alter expression of GluR1 and GluR2 in the BLA and NASh to examine the relevance of altered GluR expression on cocaine reward...
  60. Impact of Early-Life Seizures on Synaptic Plasticity
    Timothy Benke; Fiscal Year: 2005
    ..LTD), and the consequences of epileptogenesis: LTD induces a near complete removal of a specific GluR subunit (GluR2) from synapses by an N-ethyl-maleimide-sensitive fusion protein (NSF) -dependent mechanism while epileptiform ..
  61. Regulation of NSF and AMPA receptor by serum inducible kinase
    DANIELLE MARIE EVERS; Fiscal Year: 2010
    ..in neurons, 2) determine the influence of SNK binding NSF on NSF interaction with the AMPA receptor subunit, GluR2 and 3) examine if SNK-NSF interaction disrupts stability of AMPA receptors at the cell surface...
  62. Regulation of GluR2 expression by synaptic activity
    Stephanie Gardner; Fiscal Year: 2004
    ..are to elucidate the protein-protein interactions and signal transduction pathways involved in the recruitment of GLuR2-containing receptors in response to high frequency stimulation to synapses that formerly lacked them...
  63. Glutamate receptors in pain and addictive behaviors
    Charles Inturrisi; Fiscal Year: 2007
    ..Both projects are designed to test the hypothesis that glutamatergic receptors composed of NR1 or GluR2 subunits are necessary for the neuronal plasticity that is manifest as injury-induced pain (nociception) and the ..