GJA4

Summary

Gene Symbol: GJA4
Description: gap junction protein alpha 4
Alias: CX37, gap junction alpha-4 protein, connexin-37, gap junction protein, alpha 4, 37kDa
Species: human

Top Publications

  1. pmc Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein
    K E Reed
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Invest 91:997-1004. 1993
  2. ncbi Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia
    Sebastien Deglise
    Department of Thoracic and Vascular Surgery, University Hospital, Lausanne, Switzerland
    J Vasc Surg 41:1043-52. 2005
  3. ncbi Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes
    Jianhong Zhang
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Kidney Int 68:1171-85. 2005
  4. doi High-level connexin expression in the human juxtaglomerular apparatus
    Lisa Kurtz
    Department of Internal Medicine II, University of Regensburg, Regensburg, Germany
    Nephron Physiol 116:p1-8. 2010
  5. ncbi Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    Laurent Dupays
    Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Mol Cell Cardiol 38:787-98. 2005
  6. ncbi Opposing effects of nitric oxide on different connexins expressed in the vascular system
    P Kameritsch
    Institute of Physiology, Ludwig Maximilians University, Germany
    Cell Commun Adhes 10:305-9. 2003
  7. doi Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery
    Stéphanie Dal-Ros
    Département de Pharmacologie et Physicochimie, Unité Mixte de Recherche 7175 Centre National de Recherche Scientifique Université Louis Pasteur Strasbourg I, Faculté de Pharmacie 74, Illkirch, France
    J Pharmacol Exp Ther 328:478-86. 2009
  8. ncbi Distribution of gap junction protein connexin 37 in smooth muscle cells of the rat trachea and pulmonary artery
    K Nakamura
    Department of Anatomy, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Arch Histol Cytol 62:27-37. 1999
  9. doi Identification and expression analysis of connexin-45 and connexin-60 as major connexins in porcine oocytes
    M Nitta
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    J Anim Sci 88:3269-79. 2010
  10. ncbi Expression and role of connexins in the rat renal vasculature
    T Takenaka
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Kidney Int 73:415-22. 2008

Research Grants

  1. SiRNA therapeutics: Gap junction delivery in vitro and in vivo
    Richard T Mathias; Fiscal Year: 2013
  2. Janis M Burt; Fiscal Year: 2014
  3. Sathish Kumar; Fiscal Year: 2016
  4. Role of Gap Junctions in Blood Vessel Assembly
    Karen K Hirschi; Fiscal Year: 2012
  5. INTERCELLULAR COMMUNICATION IN MICROVESSELS
    Brian Duling; Fiscal Year: 2004
  6. COORDINATION OF FOLLICULOGENESIS AND OOGENESIS
    David Albertini; Fiscal Year: 2007
  7. MOLECULAR BIOLOGY OF INTERCELLULAR JUNCTIONS
    Daniel Goodenough; Fiscal Year: 2006
  8. Gap Junction Channel Permeability: A Mutagenic Approach
    Peter Brink; Fiscal Year: 2005
  9. Role of endothelial coupling in the vasculature
    Tara Mann; Fiscal Year: 2004
  10. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010

Detail Information

Publications214 found, 100 shown here

  1. pmc Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein
    K E Reed
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Invest 91:997-1004. 1993
    ..reaction amplification and cDNA library screening to clone DNA encoding a human gap junction protein, connexin37 (Cx37). The derived human Cx37 polypeptide contains 333 amino acids, with a predicted molecular mass of 37,238 D...
  2. ncbi Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia
    Sebastien Deglise
    Department of Thoracic and Vascular Surgery, University Hospital, Lausanne, Switzerland
    J Vasc Surg 41:1043-52. 2005
    ....
  3. ncbi Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes
    Jianhong Zhang
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Kidney Int 68:1171-85. 2005
    ..We have therefore made a comprehensive analysis of connexin expression in the renal vasculature of control and diabetic mice since elevated glucose has been reported to down-regulate connexin 43 in vascular cells in vitro...
  4. doi High-level connexin expression in the human juxtaglomerular apparatus
    Lisa Kurtz
    Department of Internal Medicine II, University of Regensburg, Regensburg, Germany
    Nephron Physiol 116:p1-8. 2010
    ..These gap junctions are formed by cell-specific expression patterns of the vascular connexins Cx37, Cx40, Cx43 and Cx45...
  5. ncbi Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    Laurent Dupays
    Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Mol Cell Cardiol 38:787-98. 2005
    ..In the mutant embryos the aorta is collapsed, and the vascular endothelial Cxs, Cx40 and Cx37, are no longer expressed in its posterior region...
  6. ncbi Opposing effects of nitric oxide on different connexins expressed in the vascular system
    P Kameritsch
    Institute of Physiology, Ludwig Maximilians University, Germany
    Cell Commun Adhes 10:305-9. 2003
    ..In the vascular system, gap junctions can be formed by four different connexins (Cx37, Cx40, Cx43 and Cx45)...
  7. doi Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery
    Stéphanie Dal-Ros
    Département de Pharmacologie et Physicochimie, Unité Mixte de Recherche 7175 Centre National de Recherche Scientifique Université Louis Pasteur Strasbourg I, Faculté de Pharmacie 74, Illkirch, France
    J Pharmacol Exp Ther 328:478-86. 2009
    ..The expression of the three connexins (Cxs), Cx37, Cx40, and Cx43, was quantified in segments of mesenteric arteries by immunohistochemistry and quantitative real-..
  8. ncbi Distribution of gap junction protein connexin 37 in smooth muscle cells of the rat trachea and pulmonary artery
    K Nakamura
    Department of Anatomy, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Arch Histol Cytol 62:27-37. 1999
    b>Connexin 37, one of the gap junction protein families, has been detected by Northern blotting in various organs and tissues, and found to be especially abundant in the lung...
  9. doi Identification and expression analysis of connexin-45 and connexin-60 as major connexins in porcine oocytes
    M Nitta
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    J Anim Sci 88:3269-79. 2010
    ..We demonstrate that there is diversity in the connexin genes expressed in mammalian oocytes, and hence in the gap junctions connecting oocytes and cumulus cells...
  10. ncbi Expression and role of connexins in the rat renal vasculature
    T Takenaka
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Kidney Int 73:415-22. 2008
    ..Intra-renal infusion of the peptides (GAP) reported to block specific gap junctions ((Cx37,43)GAP27 or (Cx40)GAP27), elevated blood pressure, plasma renin activity, and angiotensin II levels, while ..
  11. ncbi Contribution of connexins to the function of the vascular wall
    Jacques Antoine Haefliger
    Laboratory of Molecular Biology, Department of Internal Medicine, University Hospital, 19 135S Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Cardiovasc Res 62:345-56. 2004
    ..In the major arteries, endothelial cells may express three connexins isotypes, namely Connexin 37 (Cx37), Cx40 and Cx43, whereas the underlying smooth muscle cells may express Cx37, Cx40, Cx43 and Cx45...
  12. doi Heterogeneous expression of endothelial connexin (Cx) 37, Cx40, and Cx43 in rat large veins
    Tetsuichiro Inai
    Department of Developmental Molecular Anatomy, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Anat Sci Int 84:237-45. 2009
    ..The vascular endothelial cells express Cx37, Cx40, and Cx43...
  13. ncbi Heteromeric mixing of connexins: compatibility of partners and functional consequences
    E C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Cell Commun Adhes 8:199-204. 2001
    ..by Ni-NTA chromatography) to examine heteromeric mixing of Cx43 with other connexins (including Cx26, Cx37, Cx40, Cx45, and Cx56) in transfected cells...
  14. ncbi Expression of connexins in the normal and obstructed developing kidney
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Pediatr Nephrol 18:216-24. 2003
    ..Our reverse transcription-polymerase chain reaction (RT-PCR) studies demonstrate that Cx30, Cx36, Cx37, Cx40, Cx45, Cx46, and Cx50 are expressed in the kidney...
  15. ncbi Expression of connexins in embryonic mouse neocortical development
    Cima Cina
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Comp Neurol 504:298-313. 2007
    ..blot analysis, and immunohistochemistry, we found that among the family of gap junction proteins, Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 was ..
  16. pmc The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cells
    Sophie Imbeault
    Neural Regeneration Laboratory and Ottawa Institute of Systems Biology, Dept of Biochemistry, Microbiology, and Immunology, University of Ottawa, ON, Canada
    BMC Neurosci 10:13. 2009
    ..It is not known how these two signalling systems interact. Here, we examined the role of ECM components in regulating connexin expression and function in postnatal hippocampal progenitor cells...
  17. ncbi The detection of hamster connexins: a comparison of expression profiles with wild-type mouse and the cancer-prone Min mouse
    Véronique Cruciani
    Department of Environmental and Occupational Cancer, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Cell Commun Adhes 11:155-71. 2004
    ..Syrian hamster (using tissues) and 16 connexins from the Chinese hamster cell line V79, were fully (Cx30, Cx31, Cx37, Cx43 and Cx45) or partially sequenced...
  18. pmc Connexins in vascular physiology and pathology
    Anne C Brisset
    Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland
    Antioxid Redox Signal 11:267-82. 2009
    ..variations in connexin expression are observed along the vascular tree, with most common connexins being Cx37, Cx40, and Cx43...
  19. ncbi DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer
    Solveig Sirnes
    Department of Cancer Prevention, Institute for Cancer Research, Radiumhospitalet Oslo University Hospital, Oslo, Norway
    Epigenetics 6:602-9. 2011
    ..All analyzed connexins were hypermethylated in colon cancer cell lines, although at various frequencies. GJA4, GJB6 and GJD2 were hypermethylated in 60% (29/48), 25% (12/48) and 96% (46/48) of primary colorectal carcinomas, ..
  20. doi Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide
    Preet S Chadha
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Pharmacol Exp Ther 336:701-8. 2011
    ..In human mesenteric artery, myoendothelial gap junction and IK(Ca) activity are consistent with Cx37 and IK(Ca) microdomain expression and distribution...
  21. doi Sequential development of intercellular junctions in bioengineered human corneas
    M Gonzalez-Andrades
    Tissue Engineering Group, Department of Histology, University of Granada, Granada E18012, Spain
    J Tissue Eng Regen Med 3:442-9. 2009
    ..for plakoglobin 3 (PKG3), desmoglein 3 (DSG3) and desmoplakin (DSP), zonula occludens 1 (ZO-1) and 2 (ZO-2) and connexin 37 (Cx37) was higher in multilayered artificial corneas than in immature artificial corneas, as shown by both ..
  22. doi Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats
    Jia Ming
    State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, the Third Military University, Chongqing, People s Republic of China
    Shock 31:80-6. 2009
    ..The mRNA and protein expression of Cx37 and Cx40 of SMA were negatively associated with the vascular reactivity, whereas Cx43 seemed to be a positive ..
  23. ncbi Gap junctions are required for trophoblast proliferation in early human placental development
    T Nishimura
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Placenta 25:595-607. 2004
    ..We have identified transcripts for five connexin gap junction proteins in the early human placenta (Cx32, Cx37, Cx40, Cx43 and Cx45). Of these, Cx40 and Cx45 proteins immunolocalize to EVT in anchoring cell columns...
  24. doi Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney
    Charlotte Wagner
    Physiologisches Institut, Universitat Regensburg, 93040, Regensburg, Germany
    Pflugers Arch 459:151-8. 2009
    ..of Cx40 leads to strong hyperreninemia and ectopic localization of renin-producing cells; however, the relevance of Cx37 for the renin system in the kidney has not been investigated...
  25. doi Different pathways with distinct properties conduct dilations in the microcirculation in vivo
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck 23538, Germany
    Cardiovasc Res 85:604-13. 2010
    ..Because distances are quite distinct for different dilators, we hypothesized that separate pathways with distinct properties are involved...
  26. ncbi Chamber-related differences in connexin expression in the human heart
    C Vozzi
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    J Mol Cell Cardiol 31:991-1003. 1999
    ..Three additional connexin isoforms, Cx40, Cx45 and Cx37, of distinctive functional capacities in vitro, are expressed in cardiovascular cells, but our knowledge of their ..
  27. ncbi Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles
    Alexander M Simon
    Department of Physiology, College of Medicine, University of Arizona, Tucson, 85724, USA
    Cell Commun Adhes 13:61-77. 2006
    ..Here, we examined the expression pattern of Cx37 and Cx43 in mouse zona pellucida using multiple connexin-specific antibodies...
  28. pmc Diabetes reduces aortic endothelial gap junctions in ApoE-deficient mice: simvastatin exacerbates the reduction
    Charles Jia Yin Hou
    Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management Collegem, Taipei, Taiwan
    J Histochem Cytochem 56:745-52. 2008
    ..Western blotting of aortae showed reduced expression of connexin37 (Cx37) and Cx40 in the diabetic mice, which were further decreased in the simvastatin-treated diabetic mice...
  29. ncbi Expression of homocellular and heterocellular gap junctions in hamster arterioles and feed arteries
    Shaun L Sandow
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, ACT 0200 Canberra, Australia
    Cardiovasc Res 60:643-53. 2003
    ....
  30. ncbi Shear stress-induced upregulation of connexin 43 expression in endothelial cells on upstream surfaces of rat cardiac valves
    Tetsuichiro Inai
    Department of Developmental Molecular Anatomy, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, 812 8582 Fukuoka, Japan
    Histochem Cell Biol 122:477-83. 2004
    ..We therefore reasoned that we could determine the extent hemodynamic forces affect the expression of Cx37, Cx40, and Cx43 by comparing their immunohistochemical distribution on the upstream and downstream surfaces of rat ..
  31. ncbi Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping
    J A Haefliger
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 267:2057-64. 1992
    ..On the basis of their predicted molecular mass, these proteins have been designated connexin (Cx) 40 (Cx40), Cx37, Cx33, and Cx31.1...
  32. ncbi Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway
    D Lidington
    Department of Medical Biophysics and University of Western Ontario, London, Canada
    J Cell Physiol 185:117-25. 2000
    ..Endothelial cells grown in monolayers expressed mRNA for connexin 37, 40, and 43...
  33. ncbi Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells
    Tsuyoshi Sato
    Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Diabetes 51:1565-71. 2002
    ..to determine the effects of high glucose concentrations on the expression of endothelial-specific connexins (Cx37, Cx40, and Cx43), connexin phosphorylation pattern, and GJIC activity...
  34. ncbi Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function
    C E Hill
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Clin Exp Pharmacol Physiol 29:620-5. 2002
    ..The aim of the present study was to compare the expression of Cx37, 40 and 43 in the smooth muscle and endothelium of a large elastic artery and two smaller muscular arteries of the ..
  35. ncbi Connexin37 is the major connexin expressed in the media of caudal artery
    Nicole M Rummery
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Arterioscler Thromb Vasc Biol 22:1427-32. 2002
    ..the connexins (Cxs) involved in intercellular coupling within vascular muscle, the present study has quantified mRNA and protein expression for Cx37, Cx40, Cx43, and Cx45 in the caudal artery (CA) and thoracic aorta (ThA) of the rat.
  36. ncbi Cultured periodontal ligament fibroblasts express diverse connexins
    Yuji Yamaoka
    Department of Oral Functional Science, Graduate School of Dental Medicine, Hokkaido University, N13 W7, Kita ku, 060 8586, Sapporo, Japan
    Tissue Cell 34:375-80. 2002
    ..At present, 15 types of Cxs are known to exist, and six of their antibodies, anti-Cx26, Cx32, Cx37, Cx40, Cx43, and Cx45 are commercially available...
  37. ncbi Oestrogen-modulated gene expression in the human endometrium
    C Punyadeera
    Research Institute GROW, Postbus 5800, 6202, AZ Maastricht, The Netherlands
    Cell Mol Life Sci 62:239-50. 2005
    ..These observations emphasise that the regulation of endometrium maturation by oestrogen entails more then just stimulation of cell proliferation...
  38. ncbi Differential expression and localisation of connexin-37 and connexin-43 in follicles of different stages in the 4-week-old mouse ovary
    Stefan Cuoni Teilmann
    Laboratory of Reproductive Biology, Juliane Marie Centre, Rigshospitalet Section 5712, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Cell Endocrinol 234:27-35. 2005
    ..membrane-bound, aqueous channels that couple adjacent cells ionically and gap junction proteins, connexin-37 (Cx37) and connexin-43 (Cx43) both participate in sustaining proper growth and maturation of the oocyte...
  39. ncbi Connexin-dependent communication within the vascular wall: contribution to the control of arteriolar diameter
    Cor de Wit
    Institut fur Physiologie, Universitat Lubeck, Lubeck, Germany
    Adv Cardiol 42:268-83. 2006
    ..Gap junctions in vascular tissue are composed of connexins (Cx) Cx40, Cx43, Cx37 and Cx45...
  40. ncbi Descending vasa recta endothelium is an electrical syncytium
    Qingli Zhang
    Division of Nephrology N3W143, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1688-99. 2006
    ..Connexin (Cx) immunostaining showed predominant linear Cx40 and Cx43 in endothelia, whereas Cx37 stained smooth muscle actin-positive pericytes...
  41. ncbi Sub-chronic nicotine exposure induces intercellular communication failure and differential down-regulation of connexins in cultured human endothelial cells
    Stephan Haussig
    Clinic for Cardiac Surgery, University of Leipzig, Heart Centre, Strümpellstr 39, D 04289 Leipzig, Germany
    Atherosclerosis 196:210-8. 2008
    ..Tobacco abuse is still among the most important cardiovascular risk factors in modern society. We investigated whether sub-chronic nicotine exposure can induce endothelial dysfunction and communication failure...
  42. pmc Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells
    Janis M Burt
    Dept of Physiology, P O Box 245051, Univ of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 295:C1103-12. 2008
    ..To assess its potential growth-suppressive function, we stably introduced connexin 37 (Cx37) into connexin-deficient, tumorigenic rat insulinoma (Rin) cells under the control of an inducible ..
  43. pmc Reduction of electrical coupling between microvascular endothelial cells by NO depends on connexin37
    Rebecca L McKinnon
    Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada
    Am J Physiol Heart Circ Physiol 297:H93-H101. 2009
    ..In the present study, we hypothesized that NO impairs interendothelial electrical coupling in sepsis by targeting Cx37. We examined the effect of exogenous NO on coupling in monolayers of cultured microvascular endothelial cells ..
  44. doi Deletion of the FHL2 gene attenuates the formation of atherosclerotic lesions after a cholesterol-enriched diet
    Pao Hsien Chu
    The Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Life Sci 86:365-71. 2010
    ..FHL2, a member of the four and a half LIM domain (FHL) family of proteins, may play an important role in the circulatory system and in particular atherosclerosis...
  45. pmc An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension
    Florian Alonso
    Service of Internal Medicine, Laboratory of Experimental Medicine 19 135S, University Hospital, CHUV 1011 Lausanne, Switzerland
    Cardiovasc Res 87:166-76. 2010
    ..We investigated how connexins of the endothelial cells (ECs; Cx37, Cx40) and smooth muscle cells (SMCs; Cx43, Cx45) of the aorta change during renin-dependent and -independent ..
  46. doi Connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells
    Takayuki Okamoto
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu City, Mie 514 8507, Japan
    Exp Cell Res 317:348-55. 2011
    ..GJs of vascular ECs are assembled from Cx37, Cx40, and Cx43, and we showed that ECs also express Cx32...
  47. doi Knock-down of endothelial connexins impairs angiogenesis
    Christiane Gärtner
    Department of Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Pharmacol Res 65:347-57. 2012
    ..cells were treated with nicotine or the gap junction inhibitor palmitoleic acid (PA), or siRNA-knock-down of either Cx37, Cx40 or Cx43 was performed...
  48. pmc Connexin45 is expressed in vascular smooth muscle but its function remains elusive
    Volker J Schmidt
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    PLoS ONE 7:e42287. 2012
    Connexins (Cx) form gap junctions and allow the coordination of cellular behaviour. In vessels, expression of Cx40, Cx37, and Cx43 is well established and specifically Cx40 serves important functions in endothelial cells...
  49. doi Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms
    Tao Huang
    Department of Anatomy and Cell Biology, University of Western Ontario, London ON N6A 5C1, Canada
    J Cell Sci 126:2857-66. 2013
    ..further revealed that the R76H mutant had no detectable negative effect on the function of co-expressed Cx26, Cx32, Cx37 or Cx40, whereas the R33X mutant exhibited significant dominant or trans-dominant effects on Cx43 and Cx40 as ..
  50. ncbi Mutations of the connexin 37 and 40 gap-junction genes in patients with acute myocardial infarction
    Morteza Seifi
    Biochemistry Department, Faculty ofMedicine, Tehran University of Medical Sciences, Tehran, Iran
    Clin Lab 59:343-8. 2013
    There is evidence showing the association between connexin 37 (Cx37) C1019T polymorphism and acute myocardial infarction (AMI)...
  51. doi The Connexin37 gene C1019T polymorphism and risk of coronary artery disease: a meta-analysis
    Zhijun Wu
    Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Arch Med Res 45:21-30. 2014
    ..However, previous studies yielded conflicting results. In the current study, a comprehensive meta-analysis was performed to investigate whether the C1019T polymorphism is associated with CAD risk...
  52. pmc Local effects of pregnancy on connexin proteins that mediate Ca2+-associated uterine endothelial NO synthesis
    Timothy J Morschauser
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, PAB1, Meriter Hospital Park, 202 S Park St, Madison, WI 53715
    Hypertension 63:589-94. 2014
    ..Uterine artery adaptations during gestation facilitate increases in uterine blood flow and fetal growth...
  53. ncbi Editorial: renal endothelial dysfunction: evolving concepts and perspectives
    Dominique Guerrot
    Department of Nephrology Rouen University Hospital 1 rue de Germont, 76031 Rouen France
    Cardiovasc Hematol Disord Drug Targets 14:1-2. 2014
    ..Although challenging, the modulation of connexin expression, especially that of Cx37, Cx40 and Cx43, may be of value in settings where the endothelial injury plays an important role, as is the case in ..
  54. ncbi Association between 1019C/T polymorphism in the connexin 37 gene and dilated cardiomyopathy
    J Tang
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Shandong University, Qilu Hospital, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, Shandong, China
    Minerva Cardioangiol 64:114-20. 2016
    The aim of this paper was to investigate the association between the connexin 37 (CX37) 1019C/T polymorphism and susceptibility to dilated cardiomyopathy (DCM).
  55. doi Interplay between connexin40 and nitric oxide signaling during hypertension
    Loïc Le Gal
    From the Departments of Medicine L L G, F A, J A H and Angiology L M, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland and Department of Cell Physiology and Metabolism, University of Geneva, Medical Center, Geneva, Switzerland P M
    Hypertension 65:910-5. 2015
    ..Under these conditions, all aortas showed increased levels of Cx40 in endothelial cells and of both Cx37 and Cx45 in smooth muscle cells...
  56. pmc Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Electronic address
    Dev Biol 405:33-46. 2015
    ..Cell culture studies have shown that Cx37 is necessary for coordinated activation of the transcription factor NFATc1, which cooperates with Foxc2 (another ..
  57. ncbi Expression of gap junction proteins Cx26, Cx31.1, Cx37, and Cx43 in developing and mature rat epidermis
    J A Goliger
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Dev Dyn 200:1-13. 1994
    ..1, Cx37, and Cx43, in fetal (embryonic day 17-18), newborn (post-natal day 0), and mature rat skin...
  58. pmc Mouse horizontal cells do not express connexin26 or connexin36
    M R Deans
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell Commun Adhes 8:361-6. 2001
    ..Cx36, Cx37, Cx43, Cx45 and Cx57 mRNA could be detected in mouse retina by RT-PCR...
  59. ncbi Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40
    Alexander M Simon
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    J Cell Sci 116:2223-36. 2003
    ..Connexin37 (Cx37) and connexin40 (Cx40) are the predominant gap-junction proteins present in mouse endothelium...
  60. pmc Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells
    Patricia E M Martin
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN
    Br J Pharmacol 144:617-27. 2005
    ..Expression of Cx37 was limited in RAECs and absent from A7r5 cells. 3...
  61. pmc Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins
    Min Wang
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL, USA
    Biochem Biophys Res Commun 333:1185-93. 2005
    ..Intercellular transfer mediated by Cx37 and Cx45 (but not Cx26 or Cx40) was inhibited when co-expressed with Cx43del(130-136)...
  62. ncbi Patch-clamp study reveals that the importance of connexin43-mediated gap junctional communication for ovarian folliculogenesis is strain specific in the mouse
    Dan Tong
    Dept of Physiology and Pharmacology, The Univ of Western Ontario, Dental Science Bldg, Rm 00073, London, ON, Canada N6A 5C1
    Am J Physiol Cell Physiol 290:C290-7. 2006
    Genetic ablation of connexin37 (Cx37) or connexin43 (Cx43), the two gap junction proteins expressed by mouse ovarian granulosa cells, has been shown to result in impaired follicle development...
  63. ncbi Endothelial gap junctions are down-regulated by arsenic trioxide
    Yusan Chou
    Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    Eur J Pharmacol 569:29-36. 2007
    ..In animals treated with As(2)O(3), endothelial gap junctions comprising Cx37, Cx40, or Cx43 were all reduced in amount, while eNOS and circulating NO levels remained unchanged...
  64. pmc Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax
    John D Kanady
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 354:253-66. 2011
    ..Here, we report that gap junction proteins, or connexins (Cxs), are required for lymphatic valvulogenesis. Cx37 and Cx43 are expressed early in mouse lymphatic development in the jugular lymph sacs, and later in development ..
  65. pmc The Increased Expression of Connexin and VEGF in Mouse Ovarian Tissue Vitrification by Follicle Stimulating Hormone
    Yanzhou Yang
    Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan 750004, China
    Biomed Res Int 2015:397264. 2015
    ..The results suggested that the expressions of Cx37, Cx43, apoptotic molecular caspase-3, and angiogenesis molecular VEGF were confirmed using immunohistochemistry, ..
  66. pmc Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy (Necturus Maculatus)
    Igor Lavrov
    Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia
    PLoS ONE 11:e0152650. 2016
    ..spinal cord expressed different types of connexins that include connexin 32 (Cx32), connexin 36 (Cx36), connexin 37 (Cx37), and connexin 43 (Cx43)...
  67. ncbi Molecular cloning, tissue distribution, and hormonal control in the ovary of Cx41 mRNA, a novel Xenopus connexin gene transcript
    G Yoshizaki
    Texas Cooperative Fish and Wildlife Research Unit, Texas Tech University, Lubbock 79409 2125, USA
    Mol Reprod Dev 42:7-18. 1995
    ..Xenopus Cx41 showed the highest homology to rat Cx37 (65% identity, 80% similarity)...
  68. ncbi Characterization of the gap junction protein connexin37 in murine endothelium, respiratory epithelium, and after transfection in human HeLa cells
    O Traub
    Institut fur Genetik, Universitat Bonn, Germany
    Eur J Cell Biol 77:313-22. 1998
    ..regions of the carboxyterminus and cytoplasmic loop or to the last 103 C-terminal amino acids of mouse connexin37 (Cx37) were used to characterize expression of this gap junctional protein in endothelium of several murine tissues...
  69. pmc Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis
    N Seo
    Department of Dermatology, Hamamatsu University School of Medicine, 3600 Handa Cho, Hamamatsu 431 3192, Japan
    Proc Natl Acad Sci U S A 97:371-6. 2000
    H-2K(b)-restricted tumor epitope peptides, including tyrosinase-related protein 2 residues 181-188 (TRP-2) and connexin 37 residues 52-59 (MUT1), were applied to permeability barrier-disrupted C57BL/6 (B6) mouse skin from which the ..
  70. ncbi Connexin37 in normal and pathological development of mouse heart and great arteries
    J A Haefliger
    Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Dev Dyn 218:331-44. 2000
    b>Cx37 is a member of the connexin family of gap junction proteins, whose distribution in heart remains controversial...
  71. ncbi Expression of connexin 37, 40, and 43 mRNA and protein in renal preglomerular arterioles
    B Arensbak
    Department of Medical Physiology, Division of Renal and Cardiovascular Research, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Histochem Cell Biol 115:479-87. 2001
    ..We investigated the expression of connexins 43, 40, and 37 (Cx43, Cx40, Cx37) mRNA and proteins in primary cultures of smooth muscle cells (SMC) from rat renal preglomerular arterioles and in ..
  72. ncbi Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats
    Yasuo Kansui
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
    Am J Physiol Heart Circ Physiol 287:H216-24. 2004
    ..Confocal laser scanning microscopy after immunofluorescent labeling with antibodies against Cx37, Cx40, and Cx43 revealed that the expression of Cx37 and Cx40 in endothelial cells of the mesenteric artery was ..
  73. pmc Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery
    Andrew T Chaytor
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Pharmacol 144:108-14. 2005
    ..to the Gap 26 and Gap 27 domains of the first and second extracellular loops of the major vascular connexins (Cx37, Cx40 and Cx43), designated as (43)Gap 26, (40)Gap 27, (37,40)Gap 26 and (37,43)Gap 27 according to Cx homology, ..
  74. ncbi Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium
    Stéphanie Rignault
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Crit Care Med 33:1302-10. 2005
    ..e., Cx37, Cx40, and Cx43)...
  75. ncbi Prolonged dark adaptation changes connexin expression in the mouse retina
    Alexandre Hiroaki Kihara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Neurosci Res 83:1331-41. 2006
    ..In the present study, we first determined whether gene expression of specific Cx (Cx26, Cx31.1, Cx36, Cx37, Cx40, Cx43, Cx45, Cx50, and Cx57) was affected by prolonged dark adaptation...
  76. ncbi Gap junctions in the ovary: expression, localization and function
    Eran Gershon
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Endocrinol 282:18-25. 2008
    ..In the ovary, gap junctions consist mainly of connexin (Cx) 43 and Cx37, and their indispensable role in regulating folliculogenesis and oogenesis is well established...
  77. pmc Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice
    Ayako Makino
    Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0618, USA
    Am J Physiol Cell Physiol 295:C221-30. 2008
    ..Coronary ECs isolated from diabetic mice exhibit lowered protein levels of Cx37 and Cx40 (but not Cx43) and a loss of gap junction intercellular communication (GJIC)...
  78. doi Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells
    M A Westhoff
    Department of Hematology Oncology, University Children s Hospital, Ulm, Germany
    Oncogene 27:5169-81. 2008
    ..tunnels) through chemical inhibition with carbenoxyolone or co-incubation with the connexin-mimicking Gap 27 Cx37,43 peptide, GBM cells were sensitized to tumor necrosis factor-related apoptosis-inducing ligand- and CD95-induced ..
  79. doi Connexin abundance in resistance vessels from the renal microcirculation in normo- and hypertensive rats
    Thomas Hartig Braunstein
    Danish National Research Foundation Center for Cardiac Arrhythmia Research, Division of Renal and Microvascular Research, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark
    APMIS 117:268-76. 2009
    ..To test this hypothesis, the amount of connexin 37 (Cx37), Cx40 and Cx43 was assessed in renal arterioles from normo- and hypertensive rats using quantitative ..
  80. doi Premeiotic fetal murine germ cells cultured in vitro form typical oocyte-like cells but do not progress through meiosis
    H S Dong
    Laboratory of Germ Cell Biology, Institute of Animal Reproduction Development and Genetic Engineering, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong, China
    Theriogenology 72:219-31. 2009
    ..6 vs. 142+/-9.5, respectively; P<0.01), and the ovaries had less mRNA for Cx37 and Cx43 (P<0.01)...
  81. pmc Biological and biophysical properties of vascular connexin channels
    Scott Johnstone
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 29908, USA
    Int Rev Cell Mol Biol 278:69-118. 2009
    ..The biophysical properties of the connexin channels identified in the vasculature, those formed by Cx37, Cx40, Cx43 and/or Cx45 proteins, are discussed in this chapter in the physiological and pathophysiological context ..
  82. pmc Connexins and the kidney
    Fiona Hanner
    Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo St, Los Angeles, CA 90033, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1143-55. 2010
    ..In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the ..
  83. doi Role of connexins in microvascular dysfunction during inflammation
    Karel Tyml
    Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
    Can J Physiol Pharmacol 89:1-12. 2011
    ..Consistently, (i) exogenous NO in cultured cells reduces coupling in a Cx37-dependent manner, and (ii) the septic microvasculature in vivo shows no Cx40 phenotype...
  84. doi Direct coupling through gap junctions is not involved in urethral neurotransmission
    Maria Sancho
    Department of Physiology, Veterinary Faculty, Complutense University, Madrid, Spain
    Am J Physiol Renal Physiol 300:F864-72. 2011
    ..Hence, we investigated the distribution of different connexins (Cx 43, Cx40, and Cx37) in the sheep and rat urethra, as well as their possible role in neurotransmission...
  85. ncbi The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C>T; Pro319Ser) in women
    J Pitha
    Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Int Angiol 30:221-6. 2011
    The aim of our study was to evaluate a possible association between subclinical atherosclerosis in carotid arteries and the connexin 37 gene polymorphism (1019C>T; Pro319Ser) in a population of urban and rural women.
  86. doi Gap junctions and hydrogen peroxide are involved in endothelium-derived hyperpolarising responses to bradykinin in omental arteries and veins isolated from pregnant women
    Stephanie Hammond
    Cardiovascular Research Group, School of Biomedical Sciences, University of Nottingham, Nottingham, NG7 2UH, United Kingdom
    Eur J Pharmacol 668:225-32. 2011
    ..The expression of connexins Cx37, 40 and 43 was assessed using immunohistochemistry...
  87. pmc Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery
    Jennifer S Fang
    Department of Physiology, University of Arizona, Tucson, Arizona, USA
    Am J Physiol Heart Circ Physiol 301:H1872-81. 2011
    ..We recently reported that Cx37-deficient (Cx37(-/-)) animals recovered ischemic hindlimb function more quickly and to a greater extent than wild-..
  88. pmc Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery
    Jennifer S Fang
    Department of Physiology, University of Arizona Health Sciences Center, Tucson, Ariz, USA
    J Vasc Res 49:2-12. 2012
    ..Vascular endothelium predominantly expresses two connexin (Cx) isoforms: Cx37 and Cx40. The relevance of these Cxs to postischemic limb recovery remains unclear.
  89. doi Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
    Anna Pfenniger
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Mol Cell Cardiol 53:299-309. 2012
    ..Connexin37 (Cx37) is highly expressed in endothelial cells (ECs) of healthy arteries, but not in ECs overlying atherosclerotic ..
  90. doi Elucidating mechanisms underlying altered renal autoregulation in diabetes
    Tsuneo Takenaka
    Department of Nephrology and Community Health Science Center, Saitama Medical University, Iruma Saitama 350 0495 Japan
    Am J Physiol Regul Integr Comp Physiol 303:R495-504. 2012
    ..However, this effect was seen by neither (Cx40)GAP27 nor (Cx37,43)GAP27, which inhibits connexin (Cx) 40 or Cx37...
  91. doi [Association between 1019C/T polymorphism of Connexin 37 gene and restenosis after coronary stenting]
    Ying Yang
    Department of Cardiology, Affiliated People s Hospital of Nanjing Medical University in Wuxi and People s Hospital of Wuxi, Wuxi, Jiangsu 214023, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30:456-60. 2013
    To assess the association between 1019C/T polymorphism of Connexin 37 (CX37) gene and susceptibility to restenosis after percutaneous coronary intervention (PCI) in ethnic Han Chinese patients from Wuxi.
  92. pmc High flow conditions increase connexin43 expression in a rat arteriovenous and angioinductive loop model
    Volker J Schmidt
    Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany Department of Hand, Plastic and Reconstructive Surgery, BG Unfallklinik Ludwigshafen, Universitat Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e78782. 2013
    ..channels formed by connexins (Cx) of which four subtypes are expressed in the cardiovascular system, namely Cx37, Cx40, Cx43 and Cx45. We hypothesize that high flow conditions affect vascular expression of Cx in vivo...
  93. pmc High bone mass in mice lacking Cx37 because of defective osteoclast differentiation
    Rafael Pacheco-Costa
    From the Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202
    J Biol Chem 289:8508-20. 2014
    ..We now report that Cx37, another member of the connexin family of proteins, is expressed in osteoclasts, osteoblasts, and osteocytes...
  94. doi Association between 1019C/T polymorphism in the connexin 37 gene and essential hypertension
    Suxia Guo
    Department of Cardiology, Affiliated People s Hospital of Nanjing Medical University in Wuxi and People s Hospital of Wuxi City, Wuxi, Jiangsu, 214023 P R China Electronic address
    Heart Lung Circ 23:924-9. 2014
    ..To investigate the association between the CX 37 1019C/T polymorphism and the susceptibility to essential hypertension (EH)...
  95. doi Cx37 C1019T polymorphism may contribute to the pathogenesis of coronary heart disease
    Long Zhao
    1 Department of Respiratory, Central Hospital Affiliated to Shenyang Medical College, Shenyang, People s Republic of China
    Genet Test Mol Biomarkers 18:497-504. 2014
    We conducted a meta-analysis of case-control studies to evaluate whether Cx37 C1019T (rs1764391 C>T) polymorphism may be implicated in the pathogenesis of coronary heart disease (CHD).
  96. pmc NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions
    Kristin Pogoda
    Walter Brendel Centre of Experimental Medicine, Munich Heart Alliance, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Cell Commun Signal 12:33. 2014
    ..shown before that nitric oxide (NO) inhibits gap junctional communication in HeLa cells exclusively expressing connexin 37 (HeLa-Cx37) but not in HeLa-Cx40 or HeLa-Cx43...
  97. pmc Notch signaling functions in lymphatic valve formation
    Aino Murtomäki
    Department of Ob Gyn, Columbia University Medical Center, New York, NY 10032, USA Division of Genetics, Department of Biosciences, Viikki Biocenter, University of Helsinki, POB 56, Helsinki FIN 00014, Finland
    Development 141:2446-51. 2014
    ..Integrin α9, fibronectin EIIIA, Foxc2, calcineurin and the gap junction protein Cx37 are required for lymphatic valve formation...
  98. pmc Structural determinants and proliferative consequences of connexin 37 hemichannel function in insulinoma cells
    Miranda E Good
    From the Department of Physiology, University of Arizona, Tucson, Arizona 85724 5051
    J Biol Chem 289:30379-86. 2014
    ..The C terminus and a channel able to function are necessary, and neither by itself is sufficient, for Cx37 to mediate growth suppression...
  99. doi Reduction of connexin 37 expression by RNA interference decreases atherosclerotic plaque formation
    Suxia Guo
    Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P R China
    Mol Med Rep 11:2664-70. 2015
    The aim of this study was to examine the effects of connexin 37 (Cx37) interference on atherosclerotic plaques...
  100. doi Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37
    A Pfenniger
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland Department of Medical Specializations Cardiology, University of Geneva, Geneva, Switzerland
    Atherosclerosis 243:1-10. 2015
    ..Endothelial connexin37 (Cx37) expression is also regulated by shear stress, which may contribute to localization of atherosclerotic disease...
  101. doi Connexin 37 and 43 gene and protein expression and developmental competence of isolated ovine secondary follicles cultured in vitro after vitrification of ovarian tissue
    Andréa Moreira Sampaio da Silva
    Faculty of Veterinary Medicine, LAMOFOPA, PPGCV, State University of Ceara, Fortaleza, Ceara, Brazil
    Theriogenology 85:1457-67. 2016
    ..and organs lead to the loss of membrane proteins that mediate intercellular communications, such as connexins 37 (Cx37) and 43 (Cx43)...

Research Grants17

  1. SiRNA therapeutics: Gap junction delivery in vitro and in vivo
    Richard T Mathias; Fiscal Year: 2013
    ..In aim 1 we will determine the permeability of gap junctions made of Cx40, Cx37 and Cx43, to morpholinos and siRNAs...
  2. Janis M Burt; Fiscal Year: 2014
    ..gap junction proteins are commonly expressed in vascular cells, connexin (Cx) 37, Cx40 and Cx43;in the endothelium Cx37 and Cx40 normally predominate, but during vasculogenesis and with stress, injury and disease, Cx37 is down-..
  3. Sathish Kumar; Fiscal Year: 2016
    ..vasodilation by determining mRNA and protein levels of EDHF components SK3 and IK1 channels and connexins (CX37, CX40, and CX47), their subcellular localization, and functional activity using vascular reactivity and membrane ..
  4. Role of Gap Junctions in Blood Vessel Assembly
    Karen K Hirschi; Fiscal Year: 2012
    ..Gap junction channels can be composed of any of ~20 known connexin (Cx) proteins;however, only Cx37, Cx40, Cx43 and Cx45 are expressed in the vasculature...
  5. INTERCELLULAR COMMUNICATION IN MICROVESSELS
    Brian Duling; Fiscal Year: 2004
    ..We will include experiments on connexin 37 and 40 knockouts and newly developed smooth muscle and endothelial-cell specific knockouts of connexin 43...
  6. COORDINATION OF FOLLICULOGENESIS AND OOGENESIS
    David Albertini; Fiscal Year: 2007
    ..GCs isolated from WT pre-antral/antral or GDF-9, Cx37, or FSH-beta null animals will be analyzed in OO/GC co-culture or follicle culture to ascertain GC cell cycle ..
  7. MOLECULAR BIOLOGY OF INTERCELLULAR JUNCTIONS
    Daniel Goodenough; Fiscal Year: 2006
    ..There are three specific aims. 1) The connexin37/connexin40 (Cx37-/-/Cx40 -/-) double knockout mouse shows evidence of vascular leakage of both red cells and fluid at selected ..
  8. Gap Junction Channel Permeability: A Mutagenic Approach
    Peter Brink; Fiscal Year: 2005
    ..aims are: Aim la) Transfect mouse N2A cells or rat insulinoma cells (RIN) with mutant versions of Cx43, Cx40, and Cx37 cDNA and determine expression via Western and Northern blot analysis...
  9. Role of endothelial coupling in the vasculature
    Tara Mann; Fiscal Year: 2004
    ..unusual phenotype of a mouse line lacking two gap junction genes coding for the proteins connexin37 and connexin40 (Cx37 and Cx40) will be studied...
  10. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..In the first specific aim, the role of Cx37 and Cx40 in vascular development and angiogenesis is investigated...
  11. Vascular Cell Regulation of Connexins
    Brant Isakson; Fiscal Year: 2005
    ..These results will be compared to similar experiments on in situ wild type and connexin KO animals. Combined, these methods will help delineate the physiological role of connexins between EC and SMC. ..
  12. Physiologic Cardiovascular & Uterine eNOS Responses:Role of Endogenous Estrogen
    Ronald R Magness; Fiscal Year: 2010
    ..Data generated with the aromatase inhibitor Letrozole will directly define the role of placental estrogen produced at the maternal: fetal interface in regulating uteroplacental blood flows. ..
  13. Structure Function in Low Resistance Junctions
    Camillo Peracchia; Fiscal Year: 2005
    ..The relevance of a potential CaM binding site identified in connexins (similar to that of CaM kinase II) will be tested with deletion and mutation of crucial Cx32 residues. ..
  14. CONNEXINS AND THEIR ROLE IN EPIDERMAL DIFFERENTIATION
    Gabriele Richard; Fiscal Year: 2004
    ..We expect that these approaches provide critical information on the patho-mechanism of connexin defects in skin. ..
  15. INTERCELLULAR COMMUNICATION IN THE HEART
    Eric Beyer; Fiscal Year: 2003
    ..we will ask: What determines the limited expression patterns of two specialized cardiovascular connexins (Cx37 and Cx40)? What is the extent of natural variation of cardiovascular connexin sequences; what is the prevalence of ..
  16. CLINICAL AND GENETIC STUDIES OF NETHERTON SYNDROME
    Gabriele Richard; Fiscal Year: 2002
    ....