Genomes and Genes
Gene Symbol: GH
Description: growth hormone 1
Alias: GH-N, GHB5, GHN, IGHD1B, hGH-N, somatotropin, growth hormone B5, pituitary growth hormone
Publications213 found, 100 shown here
- Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1Thomas Thum
Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
Circ Res 100:434-43. 2007..We measured the effect of growth hormone (GH), which increases endogenous IGF-1 levels, on EPC in mice and human subjects...
- Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesisDavid Aberg
Department of Internal Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
Endocr Dev 17:63-76. 2010The growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis is not only involved in brain growth, development and myelination, but also in brain plasticity as indexed by neurogenesis...
- The GH1/IGF-1 axis polymorphisms and their impact on breast cancer developmentKerstin Wagner
Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
Breast Cancer Res Treat 104:233-48. 2007..We point out what is known about the effects of the variants and show how the interaction of genetic variants affects breast cancer risk...
- Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controlsE Bilic
Department of Neurology, University Hospital Centre, Zagreb, Croatia
Eur J Neurol 13:1340-5. 2006Neurotrophic effects of the growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin on the central nervous system have become more apparent in the past decade...
- Variable phenotypes in familial isolated growth hormone deficiency caused by a G6664A mutation in the GH-1 geneOra Hess
Faculty of Sciences, Bar Ilan University, Ramat Gan 52900, Israel
J Clin Endocrinol Metab 92:4387-93. 2007G to A transition at position 6,664 (G6664A) in human GH-1 results in the substitution of arginine by histidine at position 183 (R183H) of the GH molecule and causes familial isolated GH deficiency type II (IGHD II).
- Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsLucila Sackmann-Sala
Department of Biological Sciences, Ohio University, Athens, Ohio 45701, United States
Growth Horm IGF Res 19:471-7. 2009To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in human serum.
- Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1L S Argetsinger
Department of Physiology, University of Michigan Medical School, Ann Arbor 48109 0622, USA
J Biol Chem 270:14685-92. 1995The identification of JAK2 as a growth hormone (GH) receptor-associated, GH-activated tyrosine kinase has established tyrosyl phosphorylation as a signaling mechanism for GH...
- A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functionsBrian M Shewchuk
University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19103, USA
Mol Cell Biol 26:6535-46. 2006..These data support a model in which the Pit-1 binding sites in the hGH LCR allosterically program the bound Pit-1 complex for chromatin activating functions...
- Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patientsGiorgio Sesti
Unit of Internal Medicine, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
J Hypertens 25:471-7. 2007Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) interfere with cardiac mass (left ventricular mass; LVM) development...
- Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetesBurak Salgin
University Department of Pediatrics, Addenbrooke s Hospital, Level 8, Box 116, Cambridge CB2 0QQ, United Kingdom
J Clin Endocrinol Metab 94:3297-305. 2009Because GH stimulates lipolysis, an increase in circulating free fatty acid levels, as opposed to a direct effect of high GH levels, could underlie the development of insulin resistance in type 1 diabetes (T1D)...
- Serum insulin-like growth factor 1 and growth hormone levels of hypoxic-ischemic newbornsMehmet Satar
Division of Neonatology, Cukurova University, Adana, Turkey
Biol Neonate 85:15-20. 2004..this prospective study, we aimed at determining the levels of insulin-like growth factor 1 (IGF-1), growth hormone (GH), and cortisol in HI babies and at identifying whether they differ from the levels of control infants...
- Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell lineShunsuke Miyai
Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
Cell Tissue Res 322:269-77. 2005..Pituitary-specific transcription factor-1 (Pit-1) is required for the expression of growth hormone (GH), prolactin (PRL), and the thyroid-stimulating hormone beta subunit (TSH beta) and acts synergistically with the ..
- Isolated autosomal dominant growth hormone deficiency: stimulating mutant GH-1 gene expression drives GH-1 splice-site selection, cell proliferation, and apoptosisSouzan Salemi
Paediatric Endocrinology, University Children s Hospital, Inselspital, University of Bern, CH 3010 Bern, Switzerland
Endocrinology 148:45-53. 2007The majority of mutations that cause isolated GH deficiency type II (IGHD II) affect splicing of GH-1 transcripts and produce a dominant-negative GH isoform lacking exon 3 resulting in a 17...
- Human growth hormone and extracellular domain of its receptor: crystal structure of the complexA M de Vos
Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080
Science 255:306-12. 1992..The relative extents of the contact areas support a sequential mechanism for dimerization that may be crucial for signal transduction...
- The human growth hormone locus: nucleotide sequence, biology, and evolutionE Y Chen
Department of Molecular and Developmental Biology, Genentech, Inc, South San Francisco, California 94080
Genomics 4:479-97. 1989..This mutation results in a different splicing pattern and, hence, in a novel sequence of the hCS-L gene mRNA and the deduced polypeptide...
- Growth hormone receptor and serum binding protein: purification, cloning and expressionD W Leung
Department of Developmental Biology, Genentech, Inc, South San Francisco, California
Nature 330:537-43. 1987..The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors...
- Human growth hormone DNA sequence and mRNA structure: possible alternative splicingF M DeNoto
Nucleic Acids Res 9:3719-30. 1981..Comparison of sequences near the 5' end of the hGH mRNA with a similar region of the alpha subunit of the human glycoprotein hormones reveals an unexpected region of homology between these otherwise unrelated peptide hormones...
- The 20,000-dalton variant of human growth hormone: location of the amino acid deletionsU J Lewis
Biochem Biophys Res Commun 92:511-6. 1980
- Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study GroupA D Goddard
Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
N Engl J Med 333:1093-8. 1995Short stature in children who are not deficient in growth hormone (GH) is probably caused by a variety of defects...
- Screening for growth hormone (GH) gene splice-site mutations in sporadic cases with severe isolated GH deficiency using ectopic transcript analysisG Binder
University Children s Hospital, Tubingen, Germany
J Clin Endocrinol Metab 80:1247-52. 1995We screened 10 children with sporadic severe isolated GH deficiency (IGHD) for GH-1 gene splice site mutations using ectopic transcript analysis. None had a history of birth trauma, congenital defects, thyroid disorders, or PRL deficiency...
- A new mutation causing inherited growth hormone deficiency: a compound heterozygote of a 6.7 kb deletion and a two base deletion in the third exon of the GH-1 geneY Igarashi
Department of Pediatrics, Nagoya University School of Medicine, Japan
Hum Mol Genet 2:1073-4. 1993
- Heterogeneous growth hormone (GH) gene mutations in familial GH deficiencyJ D Cogan
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578
J Clin Endocrinol Metab 76:1224-8. 1993The GH1 genes of probands of two families with familial isolated GH deficiency (IGHD) were sequenced...
- A recurring dominant negative mutation causes autosomal dominant growth hormone deficiency--a clinical research center studyJ D Cogan
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578, USA
J Clin Endocrinol Metab 80:3591-5. 1995Familial isolated GH deficiency type II (IGHD-II) is an autosomal dominant disorder that has been previously shown in some patients to be caused by heterogeneous GH gene defects that affect GH messenger RNA (mRNA) splicing...
- Brief report: short stature caused by a mutant growth hormoneY Takahashi
Department of Medicine, Kobe University School of Medicine, Japan
N Engl J Med 334:432-6. 1996
- Biologically inactive growth hormone caused by an amino acid substitutionY Takahashi
Third Division, Department of Medicine, Kobe University School of Medicine, Kobe, 650, Japan
J Clin Invest 100:1159-65. 1997Short stature caused by biologically inactive growth hormone (GH) is characterized by lack of GH action despite high immunoassayable GH levels in serum and marked catch-up growth to exogenous GH administration...
- Mutations in intron 3 of GH-1 gene associated with isolated GH deficiency type II in three Japanese familiesT Kamijo
Department of Paediatrics, Nagoya University School of Medicine, Nagoya Kamiida Daiichi General Hospital, Nagoya, Japan
Clin Endocrinol (Oxf) 51:355-60. 1999Isolated GH deficiency (IGHD) type II is a disorder inherited in an autosomal dominant manner. Three mutations at the donor splice site of intron 3 of the GH-I gene have been identified in five families...
- Autosomal dominant GH deficiency due to an Arg183His GH-1 gene mutation: clinical and molecular evidence of impaired regulated GH secretionJ Deladoey
Division of Pediatric Endocrinology, University Children s Hospital, CH 3010 Bern, Switzerland
J Clin Endocrinol Metab 86:3941-7. 2001G to A transition at position 6664 of the GH-1 gene results in the substitution of Arg183 by His (R183H) in human GH protein and causes a new form of autosomal dominant isolated GH deficiency (type II)...
- An exon splice enhancer mutation causes autosomal dominant GH deficiencyChanda T Moseley
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578, USA
J Clin Endocrinol Metab 87:847-52. 2002Familial isolated GH deficiency type II (IGHD II) is caused, in some cases, by heterogeneous IVS3 mutations that affect GH mRNA splicing...
- A defined locus control region determinant links chromatin domain acetylation with long-range gene activationYugong Ho
Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Cell 9:291-302. 2002..These data support a model for long-range gene activation via LCR-mediated targeting and extensive spreading of core histone acetylation...
- A novel and de novo splice-donor site mutation in intron 3 of the GH-1 gene in a patient with isolated growth hormone deficiencyN Katsumata
Department of Endocrinology and Metabolism, National Children s Medical Research Center, Tokyo 154 8509, Japan
Growth Horm IGF Res 11:378-83. 2001Heterozygous mutations at the splice-donor site of inron 3 of the GH-1 gene are known to affect growth hormone (GH) mRNA splicing and cause isolated GH deficiency (IGHD), which is inherited in an autosomal dominant trait...
- An exonic mutation of the GH-1 gene causing familial isolated growth hormone deficiency type III Takahashi
Department of Pediatrics, Akita University School of Medicine, Akita, Japan
Clin Genet 61:222-5. 2002A heterozygous base change was identified in exon 3 of the growth hormone (GH)-1 gene in a Japanese family with autosomal dominant GH deficiency...
- A novel IVS2 -2A>T splicing mutation in the GH-1 gene in familial isolated growth hormone deficiency type II in the spectrum of other splicing mutations in the Russian populationOlga V Fofanova
Russian Academy of Medical Sciences, Department of Pediatrics, Endocrinology Research Center, Moscow 117036, Russia
J Clin Endocrinol Metab 88:820-6. 2003Isolated GH deficiency (IGHD) is characterized by genetic heterogeneity, both in familial and sporadic cases...
- Human growth hormone 1 (GH1) gene expression: complex haplotype-dependent influence of polymorphic variation in the proximal promoter and locus control regionMartin Horan
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, UK
Hum Mutat 21:408-23. 2003..The genetic basis of inter-individual differences in GH1 gene expression thus appears to be extremely complex...
- Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short statureDavid S Millar
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, UK
Hum Mutat 21:424-40. 2003..Molecular modeling suggested that both K41R and T175A might compromise GH receptor binding...
- Disruption of exon definition produces a dominant-negative growth hormone isoform that causes somatotroph death and IGHD IIRobin C C Ryther
Box 1820 Station B, Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Hum Genet 113:140-8. 2003..5-kDa isoform in humans also cause a dose-dependent disruption of GH secretory vesicles when expressed in GC cells and transgenic mice...
- GH1 splicing is regulated by multiple enhancers whose mutation produces a dominant-negative GH isoform that can be degraded by allele-specific small interfering RNA (siRNA)Robin C C Ryther
Box 1820 Station B, Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
Endocrinology 145:2988-96. 2004The majority of mutations that cause isolated GH deficiency type II affect splicing of GH1 transcripts, leading to the production of a dominant-negative GH isoform...
- Genetic polymorphisms in the human growth hormone-1 gene (GH1) and the risk of breast carcinomaZefang Ren
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Cancer 101:251-7. 2004..The authors investigated the association of breast carcinoma with genetic polymorphisms in the GH1 gene in the Shanghai Breast Cancer Study...
- Polymorphism in the growth hormone gene, weight in infancy, and adult bone massE M Dennison
Medical Research Council Epidemiology Resource Center, University of Southampton, Southampton General Hospital, Southampton, United Kingdom SO16 6YD
J Clin Endocrinol Metab 89:4898-903. 2004..We examined associations between common single nucleotide polymorphisms in the human GH (GH1) gene and weight in infancy, adult bone mass and bone loss rates, and circulating GH profiles...
- Variability of isolated autosomal dominant GH deficiency (IGHD II): impact of the P89L GH mutation on clinical follow-up and GH secretionSouzan Salemi
Paediatric Endocrinology, University Children s Hospital, Inselspital, CH 3010 Bern, Switzerland
Eur J Endocrinol 153:791-802. 2005Four distinct familial types of isolated GH deficiency (IGHD) are classified, of which type II, IGHD II, is the autosomal dominant inherited form...
- A novel deletion in the GH1 gene including the IVS3 branch site responsible for autosomal dominant isolated growth hormone deficiencyDaniela Vivenza
Dipartimento di Scienze Mediche, Via Solaroli 17, 28100 Novara, Italy
J Clin Endocrinol Metab 91:980-6. 2006The majority of mutations responsible for isolated GH type II deficiency (IGHD II) lead to dominant negative deleteriously increased levels of the GH1 exon 3 skipped transcripts.
- Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and strokeMartin Horan
Institute of Medical Genetics, Cardiff University, Heath Park, CF14 4XN, Cardiff, UK
Hum Genet 119:527-40. 2006An increased prevalence of both hypertension and cerebrovascular stroke is apparent in growth hormone (GH) deficiency whilst hypertension is a frequent complication in acromegaly...
- The human growth hormone gene contains a silencer embedded within an Alu repeat in the 3'-flanking regionMiguel A Trujillo
Department of Medicine, Mayo Clinic Mayo Foundation Rochester, Minnesota 55905, USA
Mol Endocrinol 20:2559-75. 2006..The human (h) GH locus contains 44 complete and four partial Alu elements...
- The insulin-like growth factor-I response to growth hormone is increased in prepubertal children with obesity and tall statureNatacha Bouhours-Nouet
Department of Pediatrics, University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
J Clin Endocrinol Metab 92:629-35. 2007..stature [CTS; height > +2 SDS)] have normal-high serum IGF-I levels, associated with a low and broad range of GH secretion, respectively...
- Human growth hormone (GH1) gene polymorphism map in a normal-statured adult populationCristina Esteban
Department of Pediatrics and Pediatric Endocrinology, Hospital Materno Infantil Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
Clin Endocrinol (Oxf) 66:258-68. 2007..The aim of the study was to establish the complete map of GH1 gene SNPs in our control normal population and to analyse its association with adult height...
- Aging and the growth hormone/insulin like growth factor-I axisMark Sherlock
Department of Endocrinology, Division of Medical Sciences, University of Birmingham, Edgbaston B15 2TT, England
Pituitary 10:189-203. 2007Growth hormone release and IGF-I synthesis decrease with increasing age. The regulation of the GH/IGF-I system is dependent on the integrity of the hypothalamus, pituitary and liver...
- A functional common polymorphism in the vitamin D-responsive element of the GH1 promoter contributes to isolated growth hormone deficiencyMara Giordano
Laboratory of Human Genetics, Department of Medical Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
J Clin Endocrinol Metab 93:1005-12. 2008Causal mutations have been detected only in a minority of isolated GH deficiency (IGHD) patients. Idiopathic IGHD might be the result of the interaction between several low-penetrance genetic factors and the environment.
- JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cellsHui Jin
Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
Mol Endocrinol 22:1825-41. 2008Janus kinase 2 (JAK2), a tyrosine kinase that associates with the GH receptor and is activated by GH, has been implicated as a key mediator of GH signaling...
- A gene conversion hotspot in the human growth hormone (GH1) gene promoterAndreas Wolf
Institut für Medizinische Informatik und Statistik, Christian Albrechts Universitat Kiel, Kiel, Germany
Hum Mutat 30:239-47. 2009..and African groups for GH1 having acted as an acceptor of gene conversion, with at least one of the four paralogous GH gene promoters serving as the donor (and specifically GH2 in the Britons and Spaniards)...
- The growth hormone cascade and its role in mammalian growthRon G Rosenfeld
Lucile Packard Foundation for Children s Health, Stanford University, Palo Alto, CA 94301, USA
Horm Res 71:36-40. 2009The myriad actions of growth hormone (GH) are still incompletely understood, despite decades of research...
- Expanding the spectrum of mutations in GH1 and GHRHR: genetic screening in a large cohort of patients with congenital isolated growth hormone deficiencyKyriaki S Alatzoglou
Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, University College London Institute of Child Health, London WC1N 1EH, United Kingdom
J Clin Endocrinol Metab 94:3191-9. 2009It is estimated that 3-30% of cases with isolated GH deficiency (IGHD) have a genetic etiology, with a number of mutations being reported in GH1 and GHRHR...
- Growth hormone (GH) deficiency type II: a novel GH-1 gene mutation (GH-R178H) affecting secretion and actionVibor Petkovic
University Children s Hospital, Pediatric Endocrinology, Inselspital CH 3010 Bern, Switzerland
J Clin Endocrinol Metab 95:731-9. 2010Main features of the autosomal dominant form of GH deficiency (IGHD II) include markedly reduced secretion of GH combined with low concentrations of IGF-I leading to short stature.
- Characterisation of a functional intronic polymorphism in the human growth hormone (GH1) geneDavid S Millar
Institute of Medical Genetics, Cardiff University, Heath Park, UK
Hum Genomics 4:289-301. 2010..within intron 4 of the human growth hormone 1 ( GH1 ) gene, has been associated with reduced levels of circulating GH and insulin-like growth factor 1, a reduced risk of colorectal cancer and a predisposition to osteoporosis...
- The role of the hGH locus control region in somatotrope restriction of hGH-N gene expressionYugong Ho
Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
Mol Endocrinol 25:877-84. 2011Expression of mammalian GH is normally restricted to somatotropes and somatolactotropes (somatotrope lineages) in the anterior pituitary. The basis for this restriction remains incompletely understood...
- Growth hormone, ghrelin and peptide YY secretion after oral glucose administration in healthy and obese womenE Outeiriño-Blanco
Department of Endocrinology, University Hospital A Coruña, A Coruna, Spain
Horm Metab Res 43:580-6. 2011The mechanism of the altered GH secretion in obesity is unclear. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion...
- An RNA-independent linkage of noncoding transcription to long-range enhancer functionEung Jae Yoo
Departments of Genetics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Mol Cell Biol 32:2020-9. 2012..These data extend our understanding of the relationship of long-range enhancer activity to enhancer-dependent noncoding transcription and establish a model that may be of general relevance to additional mammalian loci...
- DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer functionMargaret R Fleetwood
Department of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 287:25454-65. 2012..In this "neutral" DNA context, HSII was required for the recruitment of HAT activity. These data establish HSII as a nonredundant component of the hGH LCR essential for establishment of robust levels of hGH-N gene expression...
- A novel mechanism of aberrant pre-mRNA splicing in humansJ D Cogan
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2578, USA
Hum Mol Genet 6:909-12. 1997..Interestingly, we have detected mutations in IVS3 of the human growth hormone (GH) gene that affect a putative, homologous consensus sequence and which also perturb splicing...
- Association of a common polymorphism in the human GH1 gene with colorectal neoplasiaLoic Le Marchand
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
J Natl Cancer Inst 94:454-60. 2002Growth hormone (GH) may be associated with the development of colorectal tumors directly and/or indirectly via an increased plasma level of insulin-like growth factor-I (IGF-I), which has been associated with colorectal cancer risk...
- A novel dysfunctional growth hormone variant (Ile179Met) exhibits a decreased ability to activate the extracellular signal-regulated kinase pathwayMark D Lewis
Section of Endocrinology, Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
J Clin Endocrinol Metab 89:1068-75. 2004..The Ile179Met variant was shown to exhibit a similar degree of resistance to proteolysis as wild-type GH, indicating that the introduction of Met does not cause significant misfolding...
- Association between fetal growth restriction and polymorphisms at sites -1 and +3 of pituitary growth hormone: a case-control studyRonald M Adkins
Children s Foundation Research Center and Center of Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, USA
BMC Pregnancy Childbirth 5:2. 2005..DNA sequencing was used to identify 26 single nucleotide polymorphisms in the pituitary growth hormone gene (GH1) at which all subjects were genotyped...
- Association of polymorphisms and haplotypes in the human growth hormone 1 (GH1) gene with breast cancerK Wagner
Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Heidelberg
Endocr Relat Cancer 12:917-28. 2005..The effect was marginally stronger in combination with the LCR GC haplotype (OR 0.49, 95% CI 0.23-1.01, P = 0.04)...
- Growth hormone (GH) substitution in GH-deficient patients inhibits 11beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in adipose tissueSøren Kildeberg Paulsen
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
J Clin Endocrinol Metab 91:1093-8. 2006..Increased tissue activity of cortisol may play a central role in the features of GH deficiency and the metabolic syndrome.
- Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary reportZvi Laron
Endocrinology and Diabetes Research Unit, Schneider Children s Medical Center of Israel, Petah Tikva, Israel
Growth Horm IGF Res 18:434-8. 2008There is little information on the relationship between growth hormone/insulin-like growth factor-I (GH/IGF-I) deficiency or IGF-I treatment on nonalcoholic fatty liver disease (NAFLD) a disorder linked to obesity and insulin resistance.
- A variation in a Pit-1 site in the growth hormone gene (GH1) promoter induces a differential transcriptional activityMara Giordano
Laboratorio di Genetica Umana, Dipartimento di Scienze Mediche and IRCAD, Universita del Piemonte Orientale, Novara, Italy
Mol Cell Endocrinol 249:51-7. 2006..Despite the strong effect of this polymorphism in vitro, the -75G variation was not associated to an impairment of the GH secretion in vivo.
- Isolated growth hormone deficiency and the GH-1 gene: update 2002Gerhard Binder
University Children s Hospital, Tubingen, Germany
Horm Res 58:2-6. 2002This short review will focus on the mechanisms which are thought to be directly involved in GH expression and particularly on the monogenetic disorders which were shown to cause isolated growth hormone deficiency (IGHD) due to ..
- Expression of Pit-1 in nonsomatotrope cell lines induces human growth hormone locus control region histone modification and hGH-N transcriptionKatherine A Hogan
Department of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA
J Mol Biol 390:26-44. 2009..These findings are consistent with a role for Pit-1 as an initiating factor in hGH locus activation during somatotrope ontogeny, acting through binding sites at HS-I of the hGH LCR...
- Functional characterization of the alternatively spliced, placental human growth hormone receptorM Urbanek
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia 19104
J Biol Chem 268:19025-32. 1993The human growth hormone family of peptide hormones is encoded by five genes, pituitary growth hormone (hGH-N), and four placentally expressed genes, growth hormone variant (hGH-V), chorionic somatomammotropin A and B (hCS-A, hCS-B), and ..
- [Hypothalamic GH Deficiency and gelastic seizures in a 10-year-old girl with MELAS]M Matsuzaki
Department of Pediatrics, Tokyo Women's Medical College
No To Hattatsu 23:411-6. 1991A case of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, in which a pituitary growth hormone (GH) secretion deficiency of hypothalamic origin was revealed through neuro-endocrinological examinations, was ..
- Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone/Chorionic Somatomammotropin genesLaura Sedman
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Hum Mutat 29:1181-93. 2008..The results imply that the success of an association study targeted to duplicated genes may be enhanced by prior resequencing of the study population in order to determine polymorphism distribution and relevant tag-SNPs...
- Growth hormone antibodies formation in patients treated with recombinant human growth hormoneG Ahangari
Department of Molecular Medicine and Immunology, National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran
Int J Immunopathol Pharmacol 17:33-8. 2004..The magnitude of growth response was similar to those expected from clinical experience with pituitary growth hormone. We examined sera for specific antibodies against rhGH by ELISA methods...
- Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor systemEvert Van Garderen
Department of Pathology, Utrecht University, Utrecht, The Netherlands
Mol Cell Endocrinol 197:153-65. 2002..been convincingly shown that progestins, including endogenous progesterone, induce the synthesis of growth hormone (GH) in the normal and the tumorous canine mammary gland...
- Prolactin receptor, growth hormone receptor, and putative somatolactin receptor in Mozambique tilapia: tissue specific expression and differential regulation by salinity and fastingA L Pierce
Hawaii Institute of Marine Biology, University of Hawaii, 46 007 Lilipuna Road, Kaneohe, HI 96744, USA
Gen Comp Endocrinol 154:31-40. 2007In fish, pituitary growth hormone family peptide hormones (growth hormone, GH; prolactin, PRL; somatolactin, SL) regulate essential physiological functions including osmoregulation, growth, and metabolism...
- Growth hormone binding protein and maternal body mass index in relation to placental growth hormone and insulin requirements during pregnancy in type 1 diabetic womenJens Fuglsang
Gynecological Obstetrical Research laboratory Y, Aarhus University Hospital, Skejby Sygehus, DK 8200 Aarhus N, Denmark
Growth Horm IGF Res 15:223-30. 2005In pregnancy, the growth hormone axis is shifted from pituitary growth hormone (GH) to placental growth hormone (PGH)...
- Somatostatin decreases somatostatin messenger ribonucleic acid levels in the rat periventricular nucleusM C Aguila
Department of Neurology, University of Miami, and Department of Veterans Affairs Medical Center, FL, USA
Peptides 19:1573-9. 1998..Hypothalamic SRIF, the major inhibitor of pituitary growth hormone secretion, inhibits its own release by a negative ultrashort-loop feedback mechanism...
- Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturationAnna Hrabia
Department of Animal Physiology, Agricultural University in Krakow, Al Mickiewicza 24 28, 30 059 Krakow, Poland
Cell Tissue Res 332:317-28. 2008Roles of pituitary growth hormone (GH) in female reproduction are well established...
- Insulin-like growth factor-I deficiency in children with growth hormone insensitivity: current and future treatment optionsStephen F Kemp
Section of Endocrinology, University of Arkansas for Medical Sciences at Arkansas Children s Hospital, Little Rock, AR 72202, USA
BioDrugs 23:155-63. 2009Growth hormone (GH) acts directly at the growth plate and through the production of insulin-like growth factor (IGF)-I...
- Lead attenuation of episodic growth hormone secretion in male ratsWallace D Berry
Department of Poultry Science, Auburn University, Alabama 36849 5416, USA
Int J Toxicol 21:93-8. 2002..b>Pituitary growth hormone content, episodic growth hormone release, plasma insulin-like growth factor-1 levels, and growth hormone ..
- The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6S C Chua
Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021
Mamm Genome 4:555-9. 1993..The in vitro physiology of pituitary growth hormone release in lit/lit animals suggests that an abnormality in the growth hormone releasing factor (GRF) ..
- Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort studyA J Swerdlow
Section of Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK
Lancet 360:273-7. 2002..There is evidence that raised endogenous levels of growth hormone and IGF-I might be associated with increased risk of certain solid cancers, but there have been no data on long-term risks of solid cancers after growth hormone treatment...
- Decreased pituitary growth hormone response to growth hormone-releasing factor in cafeteria-fed rats: dietary and obesity effectsG Renier
Neuroendocrinology Laboratory, Notre Dame Hospital, Montreal, Que, Canada
Neuroendocrinology 52:284-90. 1990The in vivo and in vitro growth hormone (GH) responsiveness to growth hormone-releasing factor [rGRF(1-29)NH2] was evaluated in a dietary obese rat model. Sprague-Dawley rats were divided into two groups after weaning...
- Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinomaH Kiaris
Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, New Orleans, LA 70112, USA
Proc Natl Acad Sci U S A 96:14894-8. 1999..This effect is thought to be exerted through suppression of the pituitary growth hormone-hepatic insulin-like growth factor I (IGF-I) axis and direct inhibition of autocrine/paracrine production ..
- Placental growth hormone is not suppressed by oral glucose loading in normal human pregnancyH D McIntyre
Department of Endocrinology, Mater Hospital, Stanley Street, South Brisbane, Q 4101 Australia
Horm Metab Res 34:250-3. 2002Placental growth hormone (PGH) progressively replaces pituitary growth hormone in the maternal circulation from mid-gestation onwards in human pregnancy...
- Genetic causes and treatment of isolated growth hormone deficiency-an updateKyriaki S Alatzoglou
UCL Institute of Child Health, London, UK
Nat Rev Endocrinol 6:562-76. 2010..Advances in pharmacogenomics will also optimize the treatment of isolated growth hormone deficiency and other conditions associated with short stature, for which recombinant human growth hormone is a licensed therapy...
- Growth hormone and insulin-like growth factor gene expression prior to the development of the pituitary gland in rainbow trout (Oncorhynchus mykiss) embryos reared at two temperaturesMao Li
Department of Biomedical Sciences, University of Guelph, Guelph, Canada ON N1G 2W1
Comp Biochem Physiol A Mol Integr Physiol 143:514-22. 2006..for growth hormone-1 (GH1) and -2 (GH2) and insulin-like growth factor-1 (IGF-1) and -2 (IGF-2), and whole embryo GH content was measured in early stage rainbow trout (Oncorhynchus mykiss) embryos reared at two incubation ..
- The glucocorticoid antagonist 17 alpha-methyltestosterone binds to the 10 S glucocorticoid receptor and blocks agonist-mediated dissociation of the 10 S oligomer to the 4 S deoxyribonucleic acid-binding subunitB M Raaka
Department of Medicine, New York University Medical Center, New York 10016
Mol Endocrinol 3:332-41. 1989....
- Changes in hepatic gene expression related to innate immunity, growth and iron metabolism in GH-transgenic amago salmon (Oncorhynchus masou) by cDNA subtraction and microarray analysis, and serum lysozyme activityTsukasa Mori
Laboratory of Marine Molecular Biochemistry, Department of Nihon University College of Bioresource Sciences, Kameino 1866, Fujisawa 252 8510, Japan
Gen Comp Endocrinol 151:42-54. 2007Growth hormone (GH) transgenic amago salmon (Oncorhynchus masou) were generated with a construct containing the sockeye salmon GH1 gene fused to the metallothionein-B (MT-B) promoter from the same species...
- Structural and enzymatic characterization of Os3BGlu6, a rice beta-glucosidase hydrolyzing hydrophobic glycosides and (1->3)- and (1->2)-linked disaccharidesSupriya Seshadri
School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
Plant Physiol 151:47-58. 2009..This correlates with the preference of Os3BGlu6 for short oligosaccharides and hydrophobic glycosides...
- Hydrolysis of (1,4)-beta-D-mannans in barley (Hordeum vulgare L.) is mediated by the concerted action of (1,4)-beta-D-mannan endohydrolase and beta-D-mannosidaseMaria Hrmova
School of Agriculture, Food and Wine, University of Adelaide and Australian Centre for Plant Functional Genomics, Waite Campus, Glen Osmond, SA 5064, Australia
Biochem J 399:77-90. 2006..Biol. Chem. 273, 11134-11143], which hydrolyses 4NP (4-nitrophenyl) beta-D-mannoside three times faster than 4NP beta-D-glucoside, and has an action pattern typical of a (1,4)-beta-D-mannan exohydrolase...
- Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defectsXiaorong Zhu
Department of Biochemistry and Molecular Biology, University of Chicago, and the Howard Hughes Medical Institute, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 99:10293-8. 2002..They lack mature GHRH, have low pituitary growth hormone (GH) and hepatic insulin-like growth factor-1 mRNA levels and resemble phenotypically the "little" mouse (..
- Effect of monthly administration of GHRH (fragment 1-29) with osmotic pump on the rat anterior pituitaryEwelina Motylewska
Department of Immunoendocrinology, Medical University of Łódź, Poland
Endokrynol Pol 56:927-32. 2005Growth Hormone-Releasing Hormone (GHRH) is the main factor, which regulates GH secretion and somatotrope proliferation. However, its chronic effect on anterior pituitary gland is still unknown...
- Analysis of rice glycosyl hydrolase family 1 and expression of Os4bglu12 beta-glucosidaseRodjana Opassiri
Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
BMC Plant Biol 6:33. 2006....
- Isolation, characterization and comparison of Atlantic and Chinook salmon growth hormone 1 and 2Kristian R von Schalburg
Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, V8W 3N5, Canada
BMC Genomics 9:522. 2008Growth hormone (GH) is an important regulator of skeletal growth, as well as other adapted processes in salmonids. The GH gene (gh) in salmonids is represented by duplicated, non-allelic isoforms designated as gh1 and gh2...
- [Renal glucosuria and membranous glomerulonephritis in chronic inflammatory demyelinating polyradiculoneuropathy: CIDP]K Kanemoto
Department of Pediatrics, Seinan Medical Center Hospital, Tsukuba University, Ibaraki, Japan
Nippon Jinzo Gakkai Shi 41:511-6. 1999..Additionally, pituitary growth hormone deficiency was found by endocrinological examination...
- Hypothalamic-pituitary-gonadal axis in the mutant weaver mouseN B Schwartz
Department of Neurobiology and Physiology, Northwestern University, Evanston, Ill, 60208 3520, USA
Neuroendocrinology 68:374-85. 1998..b>Pituitary growth hormone (GH) concentration was normal, with control and mutant males showing higher GH than females...
- Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomasS Petersenn
IHF Institute for Hormone and Fertility Research, University of Hamburg, Hamburg, Germany Department of Medicine, University Hospital Eppendorf, Hamburg, Germany
Clin Endocrinol (Oxf) 52:35-42. 2000Somatostatin, acting via specific receptors in the anterior pituitary, tonically inhibits pituitary growth hormone secretion and somatotroph proliferation...
- Blockade of low and high threshold Ca2+ channels by diphenylbutylpiperidine antipsychotics linked to inhibition of prolactin gene expressionJ J Enyeart
Department of Pharmacology, Ohio State University, Columbus 43210 1239
J Biol Chem 265:16373-9. 1990..DPBP) antipsychotics on Ca2+ currents and prolactin (PRL) synthesis were studied in rat pituitary growth hormone (GH) cell lines (GH3 and GH4C1)...
- The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 clusterAndreas Hofmann
Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh, Scotland
Eur J Biochem 270:2557-64. 2003..We therefore hypothesize that the cysteine motif found in the present structure, or possibly even the entire sulfur cluster, forms the molecular basis for annexin function in oxidative stress response...
- Sex differences at the initiation stage of rat liver carcinogenesis--influence of growth hormoneD Liao
Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
Carcinogenesis 14:2045-9. 1993..One group of male rats in each experiment received continuous infusion of pituitary growth hormone (GH) for one week prior to initiation to feminize the secretory pattern of GH and hepatic functions...
- Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5P Werner
Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
Genomics 42:74-82. 1997..Two loci, GLUT4 and PMP22, located on HSA17p, were mapped by FISH to dog chromosome 5 in a region also identified by the whole human chromosome 17 paint, indicating disruption of HSA17 syntenic homology at the centromere...
- [Prokaryotic expression of pilA gene of type I pilus of enteropathogenic Escherichia coli isolated from ducks and the immunoprotection effect of recombinant expression protein challenged with virulent strains]An Chun Cheng
Avian Disease Research Center, College of Animal Science and Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China
Sheng Wu Gong Cheng Xue Bao 23:440-5. 2007..coli inactivated vaccine (P > 0.05). The results show that pilA recombinant protein has some immunoprotection effect with the challenging of virulent strains of E. coli GH1.2...
- Rice family GH1 glycoside hydrolases with beta-D-glucosidase and beta-D-mannosidase activitiesTeerachai Kuntothom
School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand
Arch Biochem Biophys 491:85-95. 2009..This was primarily due to strong binding of glucosyl residues at the+2 subsite for the rice enzymes, and unfavorable interactions at this subsite with rHvBII...
- STEPHEN AARON LIEBHABER; Fiscal Year: 2014....
- Activation of Human Placental Hormonal ExpressionSTEPHEN AARON LIEBHABER; Fiscal Year: 2013..hormones are encoded in the multi-gene human growth hormone (hGH) gene cluster that also encompasses the pituitary growth hormone gene, hGH-N...
- Fetal Postnatal Regulation of Expression of the GH ReceptorRam K Menon; Fiscal Year: 2010Expression and function of the growth hormone receptor (GHR) is essential for the action of pituitary growth hormone (GH)...
- MOLECULAR PATHOPHYSIOLOGY OF GROWTH DISORDERSMICHAEL WAJNRAJCH; Fiscal Year: 2001..We hypothesize that a subset of individuals with familial severe isolated Growth Hormone (GH) deficiency have a mutation in a gene compromising the Growth Hormone axis...
- Molecular Pathophysiology of Human Growth DisordersMICHAEL WAJNRAJCH; Fiscal Year: 2002..Families and individuals with growth disorders-isolated Growth Hormone (GH) deficiency or GH excess, as well as multiple pituitary hormone deficiencies-are evaluated for mutations in ..
- Suppression of tadpole limbs: a model for organ size regulationRICHARD ELINSON; Fiscal Year: 2009Body size can be altered by pituitary growth hormone, with the largest and smallest nonobese humans varying by about 10-fold in body mass...
- Preclinical Studies: Aging, NREM sleep and GH releaseBernard Bergmann; Fiscal Year: 2004..SWS are associated with important endocrine effects, including the release of pituitary growth hormone (GH). Loss of SWS occurs early in the course of normal aging and is nearly complete by 50 years of age...
- PERINATAL MATURATION OF PITUITARY GROWTH HORMONE RELEASELeona Cuttler; Fiscal Year: 1991..research proposal focuses on maturational changes in pituitary function as a possible determinant of growth hormone (GH) release in the developing rat. The factors which regualte GH secretion in immature animals are not understood...
- GROWTH HORMONE REGULATION OF HEPATIC GENE EXPRESSIONEdward Morgan; Fiscal Year: 1992The goals of this project are evaluate the roles of the sexually differentiated pituitary growth hormone secretory pattern (GHSP), and of other hormones, in the regulation of multiple hepatic genes in the rat, and to clone cDNAs and ..
- PHYSIOLOGY AND PATHOPHYSIOLOGY OF GROWTH HORMONE VARIANTSusan Kirk; Fiscal Year: 2003..Because hCS circulates at high concentrations and has approximately 85 percent homology to pituitary growth hormone (GH), many of the GH-like biologic effects seen with pregnant Type I diabetic woman (worsening of ..
- Hedgehog Signaling and the Evolution of Genomic Regulatory ArchitectureKEVIN ANTHONY PETERSON; Fiscal Year: 2010..gneural tube, limb bud and somites) will provide essential information for understanding how this important signaling pathway functions in development and disease as well as provide insight into principles of genome organization. ..
- NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCERJing Ma; Fiscal Year: 2007..Specifically, we plan to extend the IGF hypothesis to assess the role of growth hormone (GH)/IGF/insulin-related biochemical markers in colorectal and prostate cancer...
- CONTROL OF LYMPHOCYTE DEVELOPMENTRandolph Wall; Fiscal Year: 2005..between the B29 gene and the upstream locus control region (LCR) that regulates expression of the pituitary growth hormone gene (located downstream of 829) predicts that it shields the B29 gene from inappropriate activation/..
- AGING AND SOMATOMEDINSJAMES FLORINI; Fiscal Year: 1990..growth factors (IGF-I and IGF-II) that play a major biological role in mediating the anabolic actions of pituitary growth hormone (GH)...
- GERIATRIC PSYCHOPHARMACOLOGY CRC/PESteven Ferris; Fiscal Year: 1992..A particular research emphasis will concern specific subgroups and patients with mixed or multiple diagnoses...
- CHEMISTRY AND PHYSIOLOGY OF PLACENTAL LACTOGENLouis Sherwood; Fiscal Year: 1980..of the polypeptide hormone human placental lactogen (hPL), a protein hormone closely related to human pituitary growth hormone and prolactin...
- DRUG METABOLISM: SUSCEPTIBILITY TO DELAYED TERATOGENESISBernard Shapiro; Fiscal Year: 2002..that at the time of perinatal exposure, these compounds interfere with the differentiation of the "pituitary growth hormone (GH)-hepatic p450 axis" resulting in a permanent disruption in the normal responsiveness of hepatic P450 ..
- EPIGENETIC ACTIVATION OF THE HUMAN GROWTH HORMONE GENEYugong Ho; Fiscal Year: 2007..Such understanding establishes a basis for advances in diagnosis and treatment of endocrine disorders. ..
- PRODUCTION AND FUNCTION OF GHRH IN THE IMMUNE SYSTEMDOUGLAS WEIGENT; Fiscal Year: 2003..few years, we have demonstrated that GHRH can be produced by cells of the immune system and stimulate lymphocyte GH production and influence immune function...
- Creation of a mouse model of isolated GH deficiencyRoberto Salvatori; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Absent or reduced secretion of GH (isolated GH deficiency, IGHD) causes growth failure in children...
- Molecular analysis of GHRH receptor missense mutationsRoberto Salvatori; Fiscal Year: 2004Isolated GH deficiency (IGHD) is familial in up to 30% of the cases. The most common form (type IB) has autosomal recessive transmission...
- MECHANISMS AND STRATEGIES FOR INSULIN RESISTANCE IN AIDSSteven Grinspoon; Fiscal Year: 2004..The proposed studies represent a significant collaborative effort between clinical researchers, adipocyte biologists, epidemiologists and nutritional biochemists in satisfaction of the mandate of the RFA. ..
- GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERSLoic Le Marchand; Fiscal Year: 2004..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
- 7th Intl Symposium-Neurobiology/Neuroendocrinology/AgingAndrzej Bartke; Fiscal Year: 2004..We are also seeking support for the presenters of the Special Lecture and the Keynote Lecture who will be traveling to Bregenz from the United States. ..
- MAPPING ZEBRAFISH CHROMOSOMES USING MULTICOLOR FISHRuth Phillips; Fiscal Year: 2002..This would be very helpful in positional candidate cloning of zebrafish mutants. ..
- Consequences and Treatment of Growth Hormone Deficiency in the Metabolic SyndromeSTEVEN KYLE GRINSPOON; Fiscal Year: 2010..with metabolic syndrome present with increased abdominal adiposity and therefore may have reduced growth hormone (GH) levels...
- Hawaii Colorectal Cancer Family RegistryLoic Le Marchand; Fiscal Year: 2008..We will also propose a CFR pilot study exploring the feasibility of assessing assorted mating as evidence for population stratification. ..
- GH Alternative Splicing: Mechanisms and DiseaseJOHN PHILLIPS III; Fiscal Year: 2009..Analysis of growth hormone genes from individuals with GH deficiency shows that aberrant skipping of exon 3 can produce a dominant negative 17.5kD isoform...
- Ethnic/Racial Minorities in the Colon CFRLoic Le Marchand; Fiscal Year: 2008..abstract_text> ..
- Case-Control Study of Adenoma in Sao Paulo JapaneseLoic Le Marchand; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Analytical Reconstruction of Feedback Signaling in Aging MenJohannes Veldhuis; Fiscal Year: 2008..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
- Novel Active Repressor Model of Human LDL-Receptor RegulationJohannes Veldhuis; Fiscal Year: 2008..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
- Creation and characterization of GH binding protein gene disrupted miceJohn Kopchick; Fiscal Year: 2007..We and others believe that it is highly likely that the GHBP plays a significant role in the GH/IGF- 1 axis...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 2005..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
- Androgen Effects in HIV-Infected WomenSteven Grinspoon; Fiscal Year: 2007..The studies outlined in this renewal constitute an important investigative initiative of a targeted, gender-specific therapy in this largely understudied population. ..
- Consequences of lifetime isolated Growth Hormone deficiencyRoberto Salvatori; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): GH deficiency (GHD) in adults has been associated with changes in body composition, cardiovascular function, metabolic parameters associated with cardiovascular risk, and bone density and ..
- NADPH P450 REDUCTASE--THYROID HORMONE REGULATIONDavid Waxman; Fiscal Year: 2002....
- ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXISJohannes Veldhuis; Fiscal Year: 2005....
- Ensemble Disruption of the GnRH-LH-Testosterone AxisJohannes Veldhuis; Fiscal Year: 2007..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
- Mechanistic bases for age-related androgen deficiencyJohannes Veldhuis; Fiscal Year: 2007..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
- Diet, Genetic Susceptibility and Colorectal NeoplasiaLoic Le Marchand; Fiscal Year: 2006..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
- Mammary Carcinogenesis: Growth Hormone and IGF-IDavid Kleinberg; Fiscal Year: 2006..We have proven that GH, through IGF-I, plays a pivotal role in mammary development during puberty and likely during pregnancy...
- The TGFbeta Pathway, Gene Variants and Colorectal Neopl*Loic Le Marchand; Fiscal Year: 2005..abstract_text> ..
- THE AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2005DESCRIPTION: Aging is marked by progressively reduced secretion of sex steroids (gonadopause) and GH-IGF-1 (somatopause). In the female, hyposomatotropism is especially evident in the postmenopausal estrogen-deficient state...
- Aging:Mechanisms & Prevention:34th Annual Meeting of AGEAndrzej Bartke; Fiscal Year: 2005..Financial assistance will be provided to those in training to encourage their participation in the meeting. ..
- Genetics Training Program: Implications of VariationJOHN PHILLIPS III; Fiscal Year: 2005..This emphasis will help ensure that the benefits of advances in genetics will be available to more members of society. ..
- Eighth & Ninth International Symposia on Neurobiology & Neuroendocrinology AgingAndrzej Bartke; Fiscal Year: 2007..We are also seeking partial support for the expenses of invited speakers from the United States. [unreadable] [unreadable] [unreadable]..
- Mentored Patient-Oriented Research Career Development AwardRalf Nass; Fiscal Year: 2009..The n-octanoyl group is essential for the GH (growth hormone) releasing activity...
- Consequences of generalized lack of GHRHRoberto Salvatori; Fiscal Year: 2005While mutations in the GHRH receptor cause GH deficiency (GHD), mutations in the GHRH gene have never been reported, possibly indicating that lack of GHRH may cause broader consequences than GHD, or even not allow normal development...
- MODIFIED HUMAN GROWTH HORMONEPatent Number: WO9005185-A1; Date:1990-05-17