GH

Summary

Gene Symbol: GH
Description: growth hormone 1
Alias: GH-N, GHB5, GHN, IGHD1B, hGH-N, somatotropin, growth hormone B5, pituitary growth hormone
Species: human

Top Publications

  1. ncbi Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
    Thomas Thum
    Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Circ Res 100:434-43. 2007
  2. doi Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis
    David Aberg
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
    Endocr Dev 17:63-76. 2010
  3. ncbi The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development
    Kerstin Wagner
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 104:233-48. 2007
  4. ncbi Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls
    E Bilic
    Department of Neurology, University Hospital Centre, Zagreb, Croatia
    Eur J Neurol 13:1340-5. 2006
  5. ncbi Variable phenotypes in familial isolated growth hormone deficiency caused by a G6664A mutation in the GH-1 gene
    Ora Hess
    Faculty of Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Clin Endocrinol Metab 92:4387-93. 2007
  6. pmc Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
    Lucila Sackmann-Sala
    Department of Biological Sciences, Ohio University, Athens, Ohio 45701, United States
    Growth Horm IGF Res 19:471-7. 2009
  7. ncbi Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1
    L S Argetsinger
    Department of Physiology, University of Michigan Medical School, Ann Arbor 48109 0622, USA
    J Biol Chem 270:14685-92. 1995
  8. pmc A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions
    Brian M Shewchuk
    University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19103, USA
    Mol Cell Biol 26:6535-46. 2006
  9. ncbi Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients
    Giorgio Sesti
    Unit of Internal Medicine, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    J Hypertens 25:471-7. 2007
  10. pmc Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes
    Burak Salgin
    University Department of Pediatrics, Addenbrooke s Hospital, Level 8, Box 116, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 94:3297-305. 2009

Research Grants

  1. STEPHEN AARON LIEBHABER; Fiscal Year: 2014
  2. Activation of Human Placental Hormonal Expression
    STEPHEN AARON LIEBHABER; Fiscal Year: 2013
  3. Fetal Postnatal Regulation of Expression of the GH Receptor
    Ram K Menon; Fiscal Year: 2010
  4. MOLECULAR PATHOPHYSIOLOGY OF GROWTH DISORDERS
    MICHAEL WAJNRAJCH; Fiscal Year: 2001
  5. Molecular Pathophysiology of Human Growth Disorders
    MICHAEL WAJNRAJCH; Fiscal Year: 2002
  6. Suppression of tadpole limbs: a model for organ size regulation
    RICHARD ELINSON; Fiscal Year: 2009
  7. Preclinical Studies: Aging, NREM sleep and GH release
    Bernard Bergmann; Fiscal Year: 2004
  8. PERINATAL MATURATION OF PITUITARY GROWTH HORMONE RELEASE
    Leona Cuttler; Fiscal Year: 1991
  9. GROWTH HORMONE REGULATION OF HEPATIC GENE EXPRESSION
    Edward Morgan; Fiscal Year: 1992
  10. PHYSIOLOGY AND PATHOPHYSIOLOGY OF GROWTH HORMONE VARIANT
    Susan Kirk; Fiscal Year: 2003

Patents

  1. MODIFIED HUMAN GROWTH HORMONE

Detail Information

Publications213 found, 100 shown here

  1. ncbi Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
    Thomas Thum
    Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Circ Res 100:434-43. 2007
    ..We measured the effect of growth hormone (GH), which increases endogenous IGF-1 levels, on EPC in mice and human subjects...
  2. doi Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis
    David Aberg
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
    Endocr Dev 17:63-76. 2010
    The growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis is not only involved in brain growth, development and myelination, but also in brain plasticity as indexed by neurogenesis...
  3. ncbi The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development
    Kerstin Wagner
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 104:233-48. 2007
    ..We point out what is known about the effects of the variants and show how the interaction of genetic variants affects breast cancer risk...
  4. ncbi Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls
    E Bilic
    Department of Neurology, University Hospital Centre, Zagreb, Croatia
    Eur J Neurol 13:1340-5. 2006
    Neurotrophic effects of the growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin on the central nervous system have become more apparent in the past decade...
  5. ncbi Variable phenotypes in familial isolated growth hormone deficiency caused by a G6664A mutation in the GH-1 gene
    Ora Hess
    Faculty of Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Clin Endocrinol Metab 92:4387-93. 2007
    G to A transition at position 6,664 (G6664A) in human GH-1 results in the substitution of arginine by histidine at position 183 (R183H) of the GH molecule and causes familial isolated GH deficiency type II (IGHD II).
  6. pmc Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
    Lucila Sackmann-Sala
    Department of Biological Sciences, Ohio University, Athens, Ohio 45701, United States
    Growth Horm IGF Res 19:471-7. 2009
    To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in human serum.
  7. ncbi Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1
    L S Argetsinger
    Department of Physiology, University of Michigan Medical School, Ann Arbor 48109 0622, USA
    J Biol Chem 270:14685-92. 1995
    The identification of JAK2 as a growth hormone (GH) receptor-associated, GH-activated tyrosine kinase has established tyrosyl phosphorylation as a signaling mechanism for GH...
  8. pmc A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions
    Brian M Shewchuk
    University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19103, USA
    Mol Cell Biol 26:6535-46. 2006
    ..These data support a model in which the Pit-1 binding sites in the hGH LCR allosterically program the bound Pit-1 complex for chromatin activating functions...
  9. ncbi Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients
    Giorgio Sesti
    Unit of Internal Medicine, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    J Hypertens 25:471-7. 2007
    Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) interfere with cardiac mass (left ventricular mass; LVM) development...
  10. pmc Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes
    Burak Salgin
    University Department of Pediatrics, Addenbrooke s Hospital, Level 8, Box 116, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 94:3297-305. 2009
    Because GH stimulates lipolysis, an increase in circulating free fatty acid levels, as opposed to a direct effect of high GH levels, could underlie the development of insulin resistance in type 1 diabetes (T1D)...
  11. ncbi Serum insulin-like growth factor 1 and growth hormone levels of hypoxic-ischemic newborns
    Mehmet Satar
    Division of Neonatology, Cukurova University, Adana, Turkey
    Biol Neonate 85:15-20. 2004
    ..this prospective study, we aimed at determining the levels of insulin-like growth factor 1 (IGF-1), growth hormone (GH), and cortisol in HI babies and at identifying whether they differ from the levels of control infants...
  12. ncbi Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line
    Shunsuke Miyai
    Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
    Cell Tissue Res 322:269-77. 2005
    ..Pituitary-specific transcription factor-1 (Pit-1) is required for the expression of growth hormone (GH), prolactin (PRL), and the thyroid-stimulating hormone beta subunit (TSH beta) and acts synergistically with the ..
  13. ncbi Isolated autosomal dominant growth hormone deficiency: stimulating mutant GH-1 gene expression drives GH-1 splice-site selection, cell proliferation, and apoptosis
    Souzan Salemi
    Paediatric Endocrinology, University Children s Hospital, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Endocrinology 148:45-53. 2007
    The majority of mutations that cause isolated GH deficiency type II (IGHD II) affect splicing of GH-1 transcripts and produce a dominant-negative GH isoform lacking exon 3 resulting in a 17...
  14. ncbi Human growth hormone and extracellular domain of its receptor: crystal structure of the complex
    A M de Vos
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080
    Science 255:306-12. 1992
    ..The relative extents of the contact areas support a sequential mechanism for dimerization that may be crucial for signal transduction...
  15. ncbi The human growth hormone locus: nucleotide sequence, biology, and evolution
    E Y Chen
    Department of Molecular and Developmental Biology, Genentech, Inc, South San Francisco, California 94080
    Genomics 4:479-97. 1989
    ..This mutation results in a different splicing pattern and, hence, in a novel sequence of the hCS-L gene mRNA and the deduced polypeptide...
  16. ncbi Growth hormone receptor and serum binding protein: purification, cloning and expression
    D W Leung
    Department of Developmental Biology, Genentech, Inc, South San Francisco, California
    Nature 330:537-43. 1987
    ..The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors...
  17. pmc Human growth hormone DNA sequence and mRNA structure: possible alternative splicing
    F M DeNoto
    Nucleic Acids Res 9:3719-30. 1981
    ..Comparison of sequences near the 5' end of the hGH mRNA with a similar region of the alpha subunit of the human glycoprotein hormones reveals an unexpected region of homology between these otherwise unrelated peptide hormones...
  18. ncbi The 20,000-dalton variant of human growth hormone: location of the amino acid deletions
    U J Lewis
    Biochem Biophys Res Commun 92:511-6. 1980
  19. ncbi Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group
    A D Goddard
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    N Engl J Med 333:1093-8. 1995
    Short stature in children who are not deficient in growth hormone (GH) is probably caused by a variety of defects...
  20. ncbi Screening for growth hormone (GH) gene splice-site mutations in sporadic cases with severe isolated GH deficiency using ectopic transcript analysis
    G Binder
    University Children s Hospital, Tubingen, Germany
    J Clin Endocrinol Metab 80:1247-52. 1995
    We screened 10 children with sporadic severe isolated GH deficiency (IGHD) for GH-1 gene splice site mutations using ectopic transcript analysis. None had a history of birth trauma, congenital defects, thyroid disorders, or PRL deficiency...
  21. ncbi A new mutation causing inherited growth hormone deficiency: a compound heterozygote of a 6.7 kb deletion and a two base deletion in the third exon of the GH-1 gene
    Y Igarashi
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Hum Mol Genet 2:1073-4. 1993
  22. ncbi Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency
    J D Cogan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578
    J Clin Endocrinol Metab 76:1224-8. 1993
    The GH1 genes of probands of two families with familial isolated GH deficiency (IGHD) were sequenced...
  23. ncbi A recurring dominant negative mutation causes autosomal dominant growth hormone deficiency--a clinical research center study
    J D Cogan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578, USA
    J Clin Endocrinol Metab 80:3591-5. 1995
    Familial isolated GH deficiency type II (IGHD-II) is an autosomal dominant disorder that has been previously shown in some patients to be caused by heterogeneous GH gene defects that affect GH messenger RNA (mRNA) splicing...
  24. ncbi Brief report: short stature caused by a mutant growth hormone
    Y Takahashi
    Department of Medicine, Kobe University School of Medicine, Japan
    N Engl J Med 334:432-6. 1996
  25. pmc Biologically inactive growth hormone caused by an amino acid substitution
    Y Takahashi
    Third Division, Department of Medicine, Kobe University School of Medicine, Kobe, 650, Japan
    J Clin Invest 100:1159-65. 1997
    Short stature caused by biologically inactive growth hormone (GH) is characterized by lack of GH action despite high immunoassayable GH levels in serum and marked catch-up growth to exogenous GH administration...
  26. ncbi Mutations in intron 3 of GH-1 gene associated with isolated GH deficiency type II in three Japanese families
    T Kamijo
    Department of Paediatrics, Nagoya University School of Medicine, Nagoya Kamiida Daiichi General Hospital, Nagoya, Japan
    Clin Endocrinol (Oxf) 51:355-60. 1999
    Isolated GH deficiency (IGHD) type II is a disorder inherited in an autosomal dominant manner. Three mutations at the donor splice site of intron 3 of the GH-I gene have been identified in five families...
  27. ncbi Autosomal dominant GH deficiency due to an Arg183His GH-1 gene mutation: clinical and molecular evidence of impaired regulated GH secretion
    J Deladoey
    Division of Pediatric Endocrinology, University Children s Hospital, CH 3010 Bern, Switzerland
    J Clin Endocrinol Metab 86:3941-7. 2001
    G to A transition at position 6664 of the GH-1 gene results in the substitution of Arg183 by His (R183H) in human GH protein and causes a new form of autosomal dominant isolated GH deficiency (type II)...
  28. ncbi An exon splice enhancer mutation causes autosomal dominant GH deficiency
    Chanda T Moseley
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2578, USA
    J Clin Endocrinol Metab 87:847-52. 2002
    Familial isolated GH deficiency type II (IGHD II) is caused, in some cases, by heterogeneous IVS3 mutations that affect GH mRNA splicing...
  29. ncbi A defined locus control region determinant links chromatin domain acetylation with long-range gene activation
    Yugong Ho
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell 9:291-302. 2002
    ..These data support a model for long-range gene activation via LCR-mediated targeting and extensive spreading of core histone acetylation...
  30. ncbi A novel and de novo splice-donor site mutation in intron 3 of the GH-1 gene in a patient with isolated growth hormone deficiency
    N Katsumata
    Department of Endocrinology and Metabolism, National Children s Medical Research Center, Tokyo 154 8509, Japan
    Growth Horm IGF Res 11:378-83. 2001
    Heterozygous mutations at the splice-donor site of inron 3 of the GH-1 gene are known to affect growth hormone (GH) mRNA splicing and cause isolated GH deficiency (IGHD), which is inherited in an autosomal dominant trait...
  31. ncbi An exonic mutation of the GH-1 gene causing familial isolated growth hormone deficiency type II
    I Takahashi
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Clin Genet 61:222-5. 2002
    A heterozygous base change was identified in exon 3 of the growth hormone (GH)-1 gene in a Japanese family with autosomal dominant GH deficiency...
  32. ncbi A novel IVS2 -2A>T splicing mutation in the GH-1 gene in familial isolated growth hormone deficiency type II in the spectrum of other splicing mutations in the Russian population
    Olga V Fofanova
    Russian Academy of Medical Sciences, Department of Pediatrics, Endocrinology Research Center, Moscow 117036, Russia
    J Clin Endocrinol Metab 88:820-6. 2003
    Isolated GH deficiency (IGHD) is characterized by genetic heterogeneity, both in familial and sporadic cases...
  33. ncbi Human growth hormone 1 (GH1) gene expression: complex haplotype-dependent influence of polymorphic variation in the proximal promoter and locus control region
    Martin Horan
    Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, UK
    Hum Mutat 21:408-23. 2003
    ..The genetic basis of inter-individual differences in GH1 gene expression thus appears to be extremely complex...
  34. ncbi Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature
    David S Millar
    Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, UK
    Hum Mutat 21:424-40. 2003
    ..Molecular modeling suggested that both K41R and T175A might compromise GH receptor binding...
  35. ncbi Disruption of exon definition produces a dominant-negative growth hormone isoform that causes somatotroph death and IGHD II
    Robin C C Ryther
    Box 1820 Station B, Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Hum Genet 113:140-8. 2003
    ..5-kDa isoform in humans also cause a dose-dependent disruption of GH secretory vesicles when expressed in GC cells and transgenic mice...
  36. ncbi GH1 splicing is regulated by multiple enhancers whose mutation produces a dominant-negative GH isoform that can be degraded by allele-specific small interfering RNA (siRNA)
    Robin C C Ryther
    Box 1820 Station B, Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Endocrinology 145:2988-96. 2004
    The majority of mutations that cause isolated GH deficiency type II affect splicing of GH1 transcripts, leading to the production of a dominant-negative GH isoform...
  37. ncbi Genetic polymorphisms in the human growth hormone-1 gene (GH1) and the risk of breast carcinoma
    Zefang Ren
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Cancer 101:251-7. 2004
    ..The authors investigated the association of breast carcinoma with genetic polymorphisms in the GH1 gene in the Shanghai Breast Cancer Study...
  38. ncbi Polymorphism in the growth hormone gene, weight in infancy, and adult bone mass
    E M Dennison
    Medical Research Council Epidemiology Resource Center, University of Southampton, Southampton General Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 89:4898-903. 2004
    ..We examined associations between common single nucleotide polymorphisms in the human GH (GH1) gene and weight in infancy, adult bone mass and bone loss rates, and circulating GH profiles...
  39. ncbi Variability of isolated autosomal dominant GH deficiency (IGHD II): impact of the P89L GH mutation on clinical follow-up and GH secretion
    Souzan Salemi
    Paediatric Endocrinology, University Children s Hospital, Inselspital, CH 3010 Bern, Switzerland
    Eur J Endocrinol 153:791-802. 2005
    Four distinct familial types of isolated GH deficiency (IGHD) are classified, of which type II, IGHD II, is the autosomal dominant inherited form...
  40. ncbi A novel deletion in the GH1 gene including the IVS3 branch site responsible for autosomal dominant isolated growth hormone deficiency
    Daniela Vivenza
    Dipartimento di Scienze Mediche, Via Solaroli 17, 28100 Novara, Italy
    J Clin Endocrinol Metab 91:980-6. 2006
    The majority of mutations responsible for isolated GH type II deficiency (IGHD II) lead to dominant negative deleteriously increased levels of the GH1 exon 3 skipped transcripts.
  41. ncbi Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke
    Martin Horan
    Institute of Medical Genetics, Cardiff University, Heath Park, CF14 4XN, Cardiff, UK
    Hum Genet 119:527-40. 2006
    An increased prevalence of both hypertension and cerebrovascular stroke is apparent in growth hormone (GH) deficiency whilst hypertension is a frequent complication in acromegaly...
  42. ncbi The human growth hormone gene contains a silencer embedded within an Alu repeat in the 3'-flanking region
    Miguel A Trujillo
    Department of Medicine, Mayo Clinic Mayo Foundation Rochester, Minnesota 55905, USA
    Mol Endocrinol 20:2559-75. 2006
    ..The human (h) GH locus contains 44 complete and four partial Alu elements...
  43. ncbi The insulin-like growth factor-I response to growth hormone is increased in prepubertal children with obesity and tall stature
    Natacha Bouhours-Nouet
    Department of Pediatrics, University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 92:629-35. 2007
    ..stature [CTS; height > +2 SDS)] have normal-high serum IGF-I levels, associated with a low and broad range of GH secretion, respectively...
  44. pmc Human growth hormone (GH1) gene polymorphism map in a normal-statured adult population
    Cristina Esteban
    Department of Pediatrics and Pediatric Endocrinology, Hospital Materno Infantil Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 66:258-68. 2007
    ..The aim of the study was to establish the complete map of GH1 gene SNPs in our control normal population and to analyse its association with adult height...
  45. ncbi Aging and the growth hormone/insulin like growth factor-I axis
    Mark Sherlock
    Department of Endocrinology, Division of Medical Sciences, University of Birmingham, Edgbaston B15 2TT, England
    Pituitary 10:189-203. 2007
    Growth hormone release and IGF-I synthesis decrease with increasing age. The regulation of the GH/IGF-I system is dependent on the integrity of the hypothalamus, pituitary and liver...
  46. ncbi A functional common polymorphism in the vitamin D-responsive element of the GH1 promoter contributes to isolated growth hormone deficiency
    Mara Giordano
    Laboratory of Human Genetics, Department of Medical Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    J Clin Endocrinol Metab 93:1005-12. 2008
    Causal mutations have been detected only in a minority of isolated GH deficiency (IGHD) patients. Idiopathic IGHD might be the result of the interaction between several low-penetrance genetic factors and the environment.
  47. pmc JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells
    Hui Jin
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    Mol Endocrinol 22:1825-41. 2008
    Janus kinase 2 (JAK2), a tyrosine kinase that associates with the GH receptor and is activated by GH, has been implicated as a key mediator of GH signaling...
  48. doi A gene conversion hotspot in the human growth hormone (GH1) gene promoter
    Andreas Wolf
    Institut für Medizinische Informatik und Statistik, Christian Albrechts Universitat Kiel, Kiel, Germany
    Hum Mutat 30:239-47. 2009
    ..and African groups for GH1 having acted as an acceptor of gene conversion, with at least one of the four paralogous GH gene promoters serving as the donor (and specifically GH2 in the Britons and Spaniards)...
  49. doi The growth hormone cascade and its role in mammalian growth
    Ron G Rosenfeld
    Lucile Packard Foundation for Children s Health, Stanford University, Palo Alto, CA 94301, USA
    Horm Res 71:36-40. 2009
    The myriad actions of growth hormone (GH) are still incompletely understood, despite decades of research...
  50. doi Expanding the spectrum of mutations in GH1 and GHRHR: genetic screening in a large cohort of patients with congenital isolated growth hormone deficiency
    Kyriaki S Alatzoglou
    Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, University College London Institute of Child Health, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 94:3191-9. 2009
    It is estimated that 3-30% of cases with isolated GH deficiency (IGHD) have a genetic etiology, with a number of mutations being reported in GH1 and GHRHR...
  51. doi Growth hormone (GH) deficiency type II: a novel GH-1 gene mutation (GH-R178H) affecting secretion and action
    Vibor Petkovic
    University Children s Hospital, Pediatric Endocrinology, Inselspital CH 3010 Bern, Switzerland
    J Clin Endocrinol Metab 95:731-9. 2010
    Main features of the autosomal dominant form of GH deficiency (IGHD II) include markedly reduced secretion of GH combined with low concentrations of IGF-I leading to short stature.
  52. pmc Characterisation of a functional intronic polymorphism in the human growth hormone (GH1) gene
    David S Millar
    Institute of Medical Genetics, Cardiff University, Heath Park, UK
    Hum Genomics 4:289-301. 2010
    ..within intron 4 of the human growth hormone 1 ( GH1 ) gene, has been associated with reduced levels of circulating GH and insulin-like growth factor 1, a reduced risk of colorectal cancer and a predisposition to osteoporosis...
  53. pmc The role of the hGH locus control region in somatotrope restriction of hGH-N gene expression
    Yugong Ho
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 25:877-84. 2011
    Expression of mammalian GH is normally restricted to somatotropes and somatolactotropes (somatotrope lineages) in the anterior pituitary. The basis for this restriction remains incompletely understood...
  54. doi Growth hormone, ghrelin and peptide YY secretion after oral glucose administration in healthy and obese women
    E Outeiriño-Blanco
    Department of Endocrinology, University Hospital A Coruña, A Coruna, Spain
    Horm Metab Res 43:580-6. 2011
    The mechanism of the altered GH secretion in obesity is unclear. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion...
  55. pmc An RNA-independent linkage of noncoding transcription to long-range enhancer function
    Eung Jae Yoo
    Departments of Genetics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:2020-9. 2012
    ..These data extend our understanding of the relationship of long-range enhancer activity to enhancer-dependent noncoding transcription and establish a model that may be of general relevance to additional mammalian loci...
  56. pmc DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function
    Margaret R Fleetwood
    Department of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:25454-65. 2012
    ..In this "neutral" DNA context, HSII was required for the recruitment of HAT activity. These data establish HSII as a nonredundant component of the hGH LCR essential for establishment of robust levels of hGH-N gene expression...
  57. ncbi A novel mechanism of aberrant pre-mRNA splicing in humans
    J D Cogan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2578, USA
    Hum Mol Genet 6:909-12. 1997
    ..Interestingly, we have detected mutations in IVS3 of the human growth hormone (GH) gene that affect a putative, homologous consensus sequence and which also perturb splicing...
  58. ncbi Association of a common polymorphism in the human GH1 gene with colorectal neoplasia
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    J Natl Cancer Inst 94:454-60. 2002
    Growth hormone (GH) may be associated with the development of colorectal tumors directly and/or indirectly via an increased plasma level of insulin-like growth factor-I (IGF-I), which has been associated with colorectal cancer risk...
  59. ncbi A novel dysfunctional growth hormone variant (Ile179Met) exhibits a decreased ability to activate the extracellular signal-regulated kinase pathway
    Mark D Lewis
    Section of Endocrinology, Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Clin Endocrinol Metab 89:1068-75. 2004
    ..The Ile179Met variant was shown to exhibit a similar degree of resistance to proteolysis as wild-type GH, indicating that the introduction of Met does not cause significant misfolding...
  60. pmc Association between fetal growth restriction and polymorphisms at sites -1 and +3 of pituitary growth hormone: a case-control study
    Ronald M Adkins
    Children s Foundation Research Center and Center of Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, USA
    BMC Pregnancy Childbirth 5:2. 2005
    ..DNA sequencing was used to identify 26 single nucleotide polymorphisms in the pituitary growth hormone gene (GH1) at which all subjects were genotyped...
  61. ncbi Association of polymorphisms and haplotypes in the human growth hormone 1 (GH1) gene with breast cancer
    K Wagner
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Heidelberg
    Endocr Relat Cancer 12:917-28. 2005
    ..The effect was marginally stronger in combination with the LCR GC haplotype (OR 0.49, 95% CI 0.23-1.01, P = 0.04)...
  62. ncbi Growth hormone (GH) substitution in GH-deficient patients inhibits 11beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in adipose tissue
    Søren Kildeberg Paulsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 91:1093-8. 2006
    ..Increased tissue activity of cortisol may play a central role in the features of GH deficiency and the metabolic syndrome.
  63. doi Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary report
    Zvi Laron
    Endocrinology and Diabetes Research Unit, Schneider Children s Medical Center of Israel, Petah Tikva, Israel
    Growth Horm IGF Res 18:434-8. 2008
    There is little information on the relationship between growth hormone/insulin-like growth factor-I (GH/IGF-I) deficiency or IGF-I treatment on nonalcoholic fatty liver disease (NAFLD) a disorder linked to obesity and insulin resistance.
  64. ncbi A variation in a Pit-1 site in the growth hormone gene (GH1) promoter induces a differential transcriptional activity
    Mara Giordano
    Laboratorio di Genetica Umana, Dipartimento di Scienze Mediche and IRCAD, Universita del Piemonte Orientale, Novara, Italy
    Mol Cell Endocrinol 249:51-7. 2006
    ..Despite the strong effect of this polymorphism in vitro, the -75G variation was not associated to an impairment of the GH secretion in vivo.
  65. ncbi Isolated growth hormone deficiency and the GH-1 gene: update 2002
    Gerhard Binder
    University Children s Hospital, Tubingen, Germany
    Horm Res 58:2-6. 2002
    This short review will focus on the mechanisms which are thought to be directly involved in GH expression and particularly on the monogenetic disorders which were shown to cause isolated growth hormone deficiency (IGHD) due to ..
  66. doi Expression of Pit-1 in nonsomatotrope cell lines induces human growth hormone locus control region histone modification and hGH-N transcription
    Katherine A Hogan
    Department of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA
    J Mol Biol 390:26-44. 2009
    ..These findings are consistent with a role for Pit-1 as an initiating factor in hGH locus activation during somatotrope ontogeny, acting through binding sites at HS-I of the hGH LCR...
  67. ncbi Functional characterization of the alternatively spliced, placental human growth hormone receptor
    M Urbanek
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia 19104
    J Biol Chem 268:19025-32. 1993
    The human growth hormone family of peptide hormones is encoded by five genes, pituitary growth hormone (hGH-N), and four placentally expressed genes, growth hormone variant (hGH-V), chorionic somatomammotropin A and B (hCS-A, hCS-B), and ..
  68. ncbi [Hypothalamic GH Deficiency and gelastic seizures in a 10-year-old girl with MELAS]
    M Matsuzaki
    Department of Pediatrics, Tokyo Women's Medical College
    No To Hattatsu 23:411-6. 1991
    A case of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, in which a pituitary growth hormone (GH) secretion deficiency of hypothalamic origin was revealed through neuro-endocrinological examinations, was ..
  69. pmc Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone/Chorionic Somatomammotropin genes
    Laura Sedman
    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    Hum Mutat 29:1181-93. 2008
    ..The results imply that the success of an association study targeted to duplicated genes may be enhanced by prior resequencing of the study population in order to determine polymorphism distribution and relevant tag-SNPs...
  70. ncbi Growth hormone antibodies formation in patients treated with recombinant human growth hormone
    G Ahangari
    Department of Molecular Medicine and Immunology, National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran
    Int J Immunopathol Pharmacol 17:33-8. 2004
    ..The magnitude of growth response was similar to those expected from clinical experience with pituitary growth hormone. We examined sera for specific antibodies against rhGH by ELISA methods...
  71. ncbi Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system
    Evert Van Garderen
    Department of Pathology, Utrecht University, Utrecht, The Netherlands
    Mol Cell Endocrinol 197:153-65. 2002
    ..been convincingly shown that progestins, including endogenous progesterone, induce the synthesis of growth hormone (GH) in the normal and the tumorous canine mammary gland...
  72. ncbi Prolactin receptor, growth hormone receptor, and putative somatolactin receptor in Mozambique tilapia: tissue specific expression and differential regulation by salinity and fasting
    A L Pierce
    Hawaii Institute of Marine Biology, University of Hawaii, 46 007 Lilipuna Road, Kaneohe, HI 96744, USA
    Gen Comp Endocrinol 154:31-40. 2007
    In fish, pituitary growth hormone family peptide hormones (growth hormone, GH; prolactin, PRL; somatolactin, SL) regulate essential physiological functions including osmoregulation, growth, and metabolism...
  73. ncbi Growth hormone binding protein and maternal body mass index in relation to placental growth hormone and insulin requirements during pregnancy in type 1 diabetic women
    Jens Fuglsang
    Gynecological Obstetrical Research laboratory Y, Aarhus University Hospital, Skejby Sygehus, DK 8200 Aarhus N, Denmark
    Growth Horm IGF Res 15:223-30. 2005
    In pregnancy, the growth hormone axis is shifted from pituitary growth hormone (GH) to placental growth hormone (PGH)...
  74. ncbi Somatostatin decreases somatostatin messenger ribonucleic acid levels in the rat periventricular nucleus
    M C Aguila
    Department of Neurology, University of Miami, and Department of Veterans Affairs Medical Center, FL, USA
    Peptides 19:1573-9. 1998
    ..Hypothalamic SRIF, the major inhibitor of pituitary growth hormone secretion, inhibits its own release by a negative ultrashort-loop feedback mechanism...
  75. doi Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation
    Anna Hrabia
    Department of Animal Physiology, Agricultural University in Krakow, Al Mickiewicza 24 28, 30 059 Krakow, Poland
    Cell Tissue Res 332:317-28. 2008
    Roles of pituitary growth hormone (GH) in female reproduction are well established...
  76. doi Insulin-like growth factor-I deficiency in children with growth hormone insensitivity: current and future treatment options
    Stephen F Kemp
    Section of Endocrinology, University of Arkansas for Medical Sciences at Arkansas Children s Hospital, Little Rock, AR 72202, USA
    BioDrugs 23:155-63. 2009
    Growth hormone (GH) acts directly at the growth plate and through the production of insulin-like growth factor (IGF)-I...
  77. ncbi Lead attenuation of episodic growth hormone secretion in male rats
    Wallace D Berry
    Department of Poultry Science, Auburn University, Alabama 36849 5416, USA
    Int J Toxicol 21:93-8. 2002
    ..b>Pituitary growth hormone content, episodic growth hormone release, plasma insulin-like growth factor-1 levels, and growth hormone ..
  78. ncbi The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6
    S C Chua
    Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021
    Mamm Genome 4:555-9. 1993
    ..The in vitro physiology of pituitary growth hormone release in lit/lit animals suggests that an abnormality in the growth hormone releasing factor (GRF) ..
  79. ncbi Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study
    A J Swerdlow
    Section of Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK
    Lancet 360:273-7. 2002
    ..There is evidence that raised endogenous levels of growth hormone and IGF-I might be associated with increased risk of certain solid cancers, but there have been no data on long-term risks of solid cancers after growth hormone treatment...
  80. ncbi Decreased pituitary growth hormone response to growth hormone-releasing factor in cafeteria-fed rats: dietary and obesity effects
    G Renier
    Neuroendocrinology Laboratory, Notre Dame Hospital, Montreal, Que, Canada
    Neuroendocrinology 52:284-90. 1990
    The in vivo and in vitro growth hormone (GH) responsiveness to growth hormone-releasing factor [rGRF(1-29)NH2] was evaluated in a dietary obese rat model. Sprague-Dawley rats were divided into two groups after weaning...
  81. pmc Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma
    H Kiaris
    Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 96:14894-8. 1999
    ..This effect is thought to be exerted through suppression of the pituitary growth hormone-hepatic insulin-like growth factor I (IGF-I) axis and direct inhibition of autocrine/paracrine production ..
  82. ncbi Placental growth hormone is not suppressed by oral glucose loading in normal human pregnancy
    H D McIntyre
    Department of Endocrinology, Mater Hospital, Stanley Street, South Brisbane, Q 4101 Australia
    Horm Metab Res 34:250-3. 2002
    Placental growth hormone (PGH) progressively replaces pituitary growth hormone in the maternal circulation from mid-gestation onwards in human pregnancy...
  83. doi Genetic causes and treatment of isolated growth hormone deficiency-an update
    Kyriaki S Alatzoglou
    UCL Institute of Child Health, London, UK
    Nat Rev Endocrinol 6:562-76. 2010
    ..Advances in pharmacogenomics will also optimize the treatment of isolated growth hormone deficiency and other conditions associated with short stature, for which recombinant human growth hormone is a licensed therapy...
  84. ncbi Growth hormone and insulin-like growth factor gene expression prior to the development of the pituitary gland in rainbow trout (Oncorhynchus mykiss) embryos reared at two temperatures
    Mao Li
    Department of Biomedical Sciences, University of Guelph, Guelph, Canada ON N1G 2W1
    Comp Biochem Physiol A Mol Integr Physiol 143:514-22. 2006
    ..for growth hormone-1 (GH1) and -2 (GH2) and insulin-like growth factor-1 (IGF-1) and -2 (IGF-2), and whole embryo GH content was measured in early stage rainbow trout (Oncorhynchus mykiss) embryos reared at two incubation ..
  85. ncbi The glucocorticoid antagonist 17 alpha-methyltestosterone binds to the 10 S glucocorticoid receptor and blocks agonist-mediated dissociation of the 10 S oligomer to the 4 S deoxyribonucleic acid-binding subunit
    B M Raaka
    Department of Medicine, New York University Medical Center, New York 10016
    Mol Endocrinol 3:332-41. 1989
    ....
  86. ncbi Changes in hepatic gene expression related to innate immunity, growth and iron metabolism in GH-transgenic amago salmon (Oncorhynchus masou) by cDNA subtraction and microarray analysis, and serum lysozyme activity
    Tsukasa Mori
    Laboratory of Marine Molecular Biochemistry, Department of Nihon University College of Bioresource Sciences, Kameino 1866, Fujisawa 252 8510, Japan
    Gen Comp Endocrinol 151:42-54. 2007
    Growth hormone (GH) transgenic amago salmon (Oncorhynchus masou) were generated with a construct containing the sockeye salmon GH1 gene fused to the metallothionein-B (MT-B) promoter from the same species...
  87. pmc Structural and enzymatic characterization of Os3BGlu6, a rice beta-glucosidase hydrolyzing hydrophobic glycosides and (1->3)- and (1->2)-linked disaccharides
    Supriya Seshadri
    School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    Plant Physiol 151:47-58. 2009
    ..This correlates with the preference of Os3BGlu6 for short oligosaccharides and hydrophobic glycosides...
  88. pmc Hydrolysis of (1,4)-beta-D-mannans in barley (Hordeum vulgare L.) is mediated by the concerted action of (1,4)-beta-D-mannan endohydrolase and beta-D-mannosidase
    Maria Hrmova
    School of Agriculture, Food and Wine, University of Adelaide and Australian Centre for Plant Functional Genomics, Waite Campus, Glen Osmond, SA 5064, Australia
    Biochem J 399:77-90. 2006
    ..Biol. Chem. 273, 11134-11143], which hydrolyses 4NP (4-nitrophenyl) beta-D-mannoside three times faster than 4NP beta-D-glucoside, and has an action pattern typical of a (1,4)-beta-D-mannan exohydrolase...
  89. pmc Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
    Xiaorong Zhu
    Department of Biochemistry and Molecular Biology, University of Chicago, and the Howard Hughes Medical Institute, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 99:10293-8. 2002
    ..They lack mature GHRH, have low pituitary growth hormone (GH) and hepatic insulin-like growth factor-1 mRNA levels and resemble phenotypically the "little" mouse (..
  90. ncbi Effect of monthly administration of GHRH (fragment 1-29) with osmotic pump on the rat anterior pituitary
    Ewelina Motylewska
    Department of Immunoendocrinology, Medical University of Łódź, Poland
    Endokrynol Pol 56:927-32. 2005
    Growth Hormone-Releasing Hormone (GHRH) is the main factor, which regulates GH secretion and somatotrope proliferation. However, its chronic effect on anterior pituitary gland is still unknown...
  91. pmc Analysis of rice glycosyl hydrolase family 1 and expression of Os4bglu12 beta-glucosidase
    Rodjana Opassiri
    Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    BMC Plant Biol 6:33. 2006
    ....
  92. pmc Isolation, characterization and comparison of Atlantic and Chinook salmon growth hormone 1 and 2
    Kristian R von Schalburg
    Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, V8W 3N5, Canada
    BMC Genomics 9:522. 2008
    Growth hormone (GH) is an important regulator of skeletal growth, as well as other adapted processes in salmonids. The GH gene (gh) in salmonids is represented by duplicated, non-allelic isoforms designated as gh1 and gh2...
  93. ncbi [Renal glucosuria and membranous glomerulonephritis in chronic inflammatory demyelinating polyradiculoneuropathy: CIDP]
    K Kanemoto
    Department of Pediatrics, Seinan Medical Center Hospital, Tsukuba University, Ibaraki, Japan
    Nippon Jinzo Gakkai Shi 41:511-6. 1999
    ..Additionally, pituitary growth hormone deficiency was found by endocrinological examination...
  94. ncbi Hypothalamic-pituitary-gonadal axis in the mutant weaver mouse
    N B Schwartz
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Ill, 60208 3520, USA
    Neuroendocrinology 68:374-85. 1998
    ..b>Pituitary growth hormone (GH) concentration was normal, with control and mutant males showing higher GH than females...
  95. ncbi Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas
    S Petersenn
    IHF Institute for Hormone and Fertility Research, University of Hamburg, Hamburg, Germany Department of Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Endocrinol (Oxf) 52:35-42. 2000
    Somatostatin, acting via specific receptors in the anterior pituitary, tonically inhibits pituitary growth hormone secretion and somatotroph proliferation...
  96. ncbi Blockade of low and high threshold Ca2+ channels by diphenylbutylpiperidine antipsychotics linked to inhibition of prolactin gene expression
    J J Enyeart
    Department of Pharmacology, Ohio State University, Columbus 43210 1239
    J Biol Chem 265:16373-9. 1990
    ..DPBP) antipsychotics on Ca2+ currents and prolactin (PRL) synthesis were studied in rat pituitary growth hormone (GH) cell lines (GH3 and GH4C1)...
  97. ncbi The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster
    Andreas Hofmann
    Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh, Scotland
    Eur J Biochem 270:2557-64. 2003
    ..We therefore hypothesize that the cysteine motif found in the present structure, or possibly even the entire sulfur cluster, forms the molecular basis for annexin function in oxidative stress response...
  98. ncbi Sex differences at the initiation stage of rat liver carcinogenesis--influence of growth hormone
    D Liao
    Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Carcinogenesis 14:2045-9. 1993
    ..One group of male rats in each experiment received continuous infusion of pituitary growth hormone (GH) for one week prior to initiation to feminize the secretory pattern of GH and hepatic functions...
  99. ncbi Physical and linkage mapping of human chromosome 17 loci to dog chromosomes 9 and 5
    P Werner
    Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    Genomics 42:74-82. 1997
    ..Two loci, GLUT4 and PMP22, located on HSA17p, were mapped by FISH to dog chromosome 5 in a region also identified by the whole human chromosome 17 paint, indicating disruption of HSA17 syntenic homology at the centromere...
  100. ncbi [Prokaryotic expression of pilA gene of type I pilus of enteropathogenic Escherichia coli isolated from ducks and the immunoprotection effect of recombinant expression protein challenged with virulent strains]
    An Chun Cheng
    Avian Disease Research Center, College of Animal Science and Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China
    Sheng Wu Gong Cheng Xue Bao 23:440-5. 2007
    ..coli inactivated vaccine (P > 0.05). The results show that pilA recombinant protein has some immunoprotection effect with the challenging of virulent strains of E. coli GH1.2...
  101. doi Rice family GH1 glycoside hydrolases with beta-D-glucosidase and beta-D-mannosidase activities
    Teerachai Kuntothom
    School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand
    Arch Biochem Biophys 491:85-95. 2009
    ..This was primarily due to strong binding of glucosyl residues at the+2 subsite for the rice enzymes, and unfavorable interactions at this subsite with rHvBII...

Research Grants51

  1. STEPHEN AARON LIEBHABER; Fiscal Year: 2014
    ....
  2. Activation of Human Placental Hormonal Expression
    STEPHEN AARON LIEBHABER; Fiscal Year: 2013
    ..hormones are encoded in the multi-gene human growth hormone (hGH) gene cluster that also encompasses the pituitary growth hormone gene, hGH-N...
  3. Fetal Postnatal Regulation of Expression of the GH Receptor
    Ram K Menon; Fiscal Year: 2010
    Expression and function of the growth hormone receptor (GHR) is essential for the action of pituitary growth hormone (GH)...
  4. MOLECULAR PATHOPHYSIOLOGY OF GROWTH DISORDERS
    MICHAEL WAJNRAJCH; Fiscal Year: 2001
    ..We hypothesize that a subset of individuals with familial severe isolated Growth Hormone (GH) deficiency have a mutation in a gene compromising the Growth Hormone axis...
  5. Molecular Pathophysiology of Human Growth Disorders
    MICHAEL WAJNRAJCH; Fiscal Year: 2002
    ..Families and individuals with growth disorders-isolated Growth Hormone (GH) deficiency or GH excess, as well as multiple pituitary hormone deficiencies-are evaluated for mutations in ..
  6. Suppression of tadpole limbs: a model for organ size regulation
    RICHARD ELINSON; Fiscal Year: 2009
    Body size can be altered by pituitary growth hormone, with the largest and smallest nonobese humans varying by about 10-fold in body mass...
  7. Preclinical Studies: Aging, NREM sleep and GH release
    Bernard Bergmann; Fiscal Year: 2004
    ..SWS are associated with important endocrine effects, including the release of pituitary growth hormone (GH). Loss of SWS occurs early in the course of normal aging and is nearly complete by 50 years of age...
  8. PERINATAL MATURATION OF PITUITARY GROWTH HORMONE RELEASE
    Leona Cuttler; Fiscal Year: 1991
    ..research proposal focuses on maturational changes in pituitary function as a possible determinant of growth hormone (GH) release in the developing rat. The factors which regualte GH secretion in immature animals are not understood...
  9. GROWTH HORMONE REGULATION OF HEPATIC GENE EXPRESSION
    Edward Morgan; Fiscal Year: 1992
    The goals of this project are evaluate the roles of the sexually differentiated pituitary growth hormone secretory pattern (GHSP), and of other hormones, in the regulation of multiple hepatic genes in the rat, and to clone cDNAs and ..
  10. PHYSIOLOGY AND PATHOPHYSIOLOGY OF GROWTH HORMONE VARIANT
    Susan Kirk; Fiscal Year: 2003
    ..Because hCS circulates at high concentrations and has approximately 85 percent homology to pituitary growth hormone (GH), many of the GH-like biologic effects seen with pregnant Type I diabetic woman (worsening of ..
  11. Hedgehog Signaling and the Evolution of Genomic Regulatory Architecture
    KEVIN ANTHONY PETERSON; Fiscal Year: 2010
    ..gneural tube, limb bud and somites) will provide essential information for understanding how this important signaling pathway functions in development and disease as well as provide insight into principles of genome organization. ..
  12. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..Specifically, we plan to extend the IGF hypothesis to assess the role of growth hormone (GH)/IGF/insulin-related biochemical markers in colorectal and prostate cancer...
  13. CONTROL OF LYMPHOCYTE DEVELOPMENT
    Randolph Wall; Fiscal Year: 2005
    ..between the B29 gene and the upstream locus control region (LCR) that regulates expression of the pituitary growth hormone gene (located downstream of 829) predicts that it shields the B29 gene from inappropriate activation/..
  14. AGING AND SOMATOMEDINS
    JAMES FLORINI; Fiscal Year: 1990
    ..growth factors (IGF-I and IGF-II) that play a major biological role in mediating the anabolic actions of pituitary growth hormone (GH)...
  15. GERIATRIC PSYCHOPHARMACOLOGY CRC/PE
    Steven Ferris; Fiscal Year: 1992
    ..A particular research emphasis will concern specific subgroups and patients with mixed or multiple diagnoses...
  16. CHEMISTRY AND PHYSIOLOGY OF PLACENTAL LACTOGEN
    Louis Sherwood; Fiscal Year: 1980
    ..of the polypeptide hormone human placental lactogen (hPL), a protein hormone closely related to human pituitary growth hormone and prolactin...
  17. DRUG METABOLISM: SUSCEPTIBILITY TO DELAYED TERATOGENESIS
    Bernard Shapiro; Fiscal Year: 2002
    ..that at the time of perinatal exposure, these compounds interfere with the differentiation of the "pituitary growth hormone (GH)-hepatic p450 axis" resulting in a permanent disruption in the normal responsiveness of hepatic P450 ..
  18. EPIGENETIC ACTIVATION OF THE HUMAN GROWTH HORMONE GENE
    Yugong Ho; Fiscal Year: 2007
    ..Such understanding establishes a basis for advances in diagnosis and treatment of endocrine disorders. ..
  19. PRODUCTION AND FUNCTION OF GHRH IN THE IMMUNE SYSTEM
    DOUGLAS WEIGENT; Fiscal Year: 2003
    ..few years, we have demonstrated that GHRH can be produced by cells of the immune system and stimulate lymphocyte GH production and influence immune function...
  20. Creation of a mouse model of isolated GH deficiency
    Roberto Salvatori; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Absent or reduced secretion of GH (isolated GH deficiency, IGHD) causes growth failure in children...
  21. Molecular analysis of GHRH receptor missense mutations
    Roberto Salvatori; Fiscal Year: 2004
    Isolated GH deficiency (IGHD) is familial in up to 30% of the cases. The most common form (type IB) has autosomal recessive transmission...
  22. MECHANISMS AND STRATEGIES FOR INSULIN RESISTANCE IN AIDS
    Steven Grinspoon; Fiscal Year: 2004
    ..The proposed studies represent a significant collaborative effort between clinical researchers, adipocyte biologists, epidemiologists and nutritional biochemists in satisfaction of the mandate of the RFA. ..
  23. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2004
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  24. 7th Intl Symposium-Neurobiology/Neuroendocrinology/Aging
    Andrzej Bartke; Fiscal Year: 2004
    ..We are also seeking support for the presenters of the Special Lecture and the Keynote Lecture who will be traveling to Bregenz from the United States. ..
  25. MAPPING ZEBRAFISH CHROMOSOMES USING MULTICOLOR FISH
    Ruth Phillips; Fiscal Year: 2002
    ..This would be very helpful in positional candidate cloning of zebrafish mutants. ..
  26. Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..with metabolic syndrome present with increased abdominal adiposity and therefore may have reduced growth hormone (GH) levels...
  27. Hawaii Colorectal Cancer Family Registry
    Loic Le Marchand; Fiscal Year: 2008
    ..We will also propose a CFR pilot study exploring the feasibility of assessing assorted mating as evidence for population stratification. ..
  28. GH Alternative Splicing: Mechanisms and Disease
    JOHN PHILLIPS III; Fiscal Year: 2009
    ..Analysis of growth hormone genes from individuals with GH deficiency shows that aberrant skipping of exon 3 can produce a dominant negative 17.5kD isoform...
  29. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2008
    ..abstract_text> ..
  30. Case-Control Study of Adenoma in Sao Paulo Japanese
    Loic Le Marchand; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  32. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  33. Creation and characterization of GH binding protein gene disrupted mice
    John Kopchick; Fiscal Year: 2007
    ..We and others believe that it is highly likely that the GHBP plays a significant role in the GH/IGF- 1 axis...
  34. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  35. Androgen Effects in HIV-Infected Women
    Steven Grinspoon; Fiscal Year: 2007
    ..The studies outlined in this renewal constitute an important investigative initiative of a targeted, gender-specific therapy in this largely understudied population. ..
  36. Consequences of lifetime isolated Growth Hormone deficiency
    Roberto Salvatori; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): GH deficiency (GHD) in adults has been associated with changes in body composition, cardiovascular function, metabolic parameters associated with cardiovascular risk, and bone density and ..
  37. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 2002
    ....
  38. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  39. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  40. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  41. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2006
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  42. Mammary Carcinogenesis: Growth Hormone and IGF-I
    David Kleinberg; Fiscal Year: 2006
    ..We have proven that GH, through IGF-I, plays a pivotal role in mammary development during puberty and likely during pregnancy...
  43. The TGFbeta Pathway, Gene Variants and Colorectal Neopl*
    Loic Le Marchand; Fiscal Year: 2005
    ..abstract_text> ..
  44. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    DESCRIPTION: Aging is marked by progressively reduced secretion of sex steroids (gonadopause) and GH-IGF-1 (somatopause). In the female, hyposomatotropism is especially evident in the postmenopausal estrogen-deficient state...
  45. Aging:Mechanisms & Prevention:34th Annual Meeting of AGE
    Andrzej Bartke; Fiscal Year: 2005
    ..Financial assistance will be provided to those in training to encourage their participation in the meeting. ..
  46. Genetics Training Program: Implications of Variation
    JOHN PHILLIPS III; Fiscal Year: 2005
    ..This emphasis will help ensure that the benefits of advances in genetics will be available to more members of society. ..
  47. Eighth & Ninth International Symposia on Neurobiology & Neuroendocrinology Aging
    Andrzej Bartke; Fiscal Year: 2007
    ..We are also seeking partial support for the expenses of invited speakers from the United States. [unreadable] [unreadable] [unreadable]..
  48. Mentored Patient-Oriented Research Career Development Award
    Ralf Nass; Fiscal Year: 2009
    ..The n-octanoyl group is essential for the GH (growth hormone) releasing activity...
  49. Consequences of generalized lack of GHRH
    Roberto Salvatori; Fiscal Year: 2005
    While mutations in the GHRH receptor cause GH deficiency (GHD), mutations in the GHRH gene have never been reported, possibly indicating that lack of GHRH may cause broader consequences than GHD, or even not allow normal development...

Patents1

  1. MODIFIED HUMAN GROWTH HORMONE
    Patent Number: WO9005185-A1; Date:1990-05-17