GFER

Summary

Gene Symbol: GFER
Description: growth factor, augmenter of liver regeneration
Alias: ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, FAD-linked sulfhydryl oxidase ALR, ERV1 homolog, erv1-like growth factor, hepatic regenerative stimulation substance, hepatopoietin protein
Species: human

Top Publications

  1. ncbi IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni
    S C Bosshardt
    Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
    Parasite Immunol 19:347-53. 1997
  2. ncbi Expression of alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli and molecular characterization of the recombinant alanine racemase
    Tadao Oikawa
    Department of Biotechnology, Faculty of Engineering, Kansai University, 3 3 35 Yamate cho, Suita, Osaka Fu 564 8680, Japan
    J Biotechnol 125:503-12. 2006
  3. ncbi Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway
    Chengrong Lu
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, Beijing 100850, P R China
    FASEB J 16:90-2. 2002
  4. ncbi Augmenter of liver regeneration: its place in the universe of hepatic growth factors
    A Francavilla
    Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213
    Hepatology 20:747-57. 1994
  5. ncbi Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription
    Yong Li
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center, China
    Eur J Biochem 269:3888-93. 2002
  6. pmc Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes
    Chinnasamy Thirunavukkarasu
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, E 1542 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Hepatol 48:578-88. 2008
  7. pmc Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space
    Vidyadhar N Daithankar
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    Biochemistry 48:4828-37. 2009
  8. pmc The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency
    Alessio Di Fonzo
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, 20122 Milan, Italy
    Am J Hum Genet 84:594-604. 2009
  9. doi Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Free Radic Biol Med 47:1057-66. 2009
  10. doi Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
    Lorenzo Polimeno
    Section of Gastroenterology, Department of Emergency and Organ Transplantation DETO, University of Bari, Bari, Italy
    Free Radic Res 43:865-75. 2009

Research Grants

  1. Characterization of redox-mediated protein in mitochondria
    SONYA ELINA NEAL; Fiscal Year: 2013
  2. Clayton E Mathews; Fiscal Year: 2015
  3. Duojia Pan; Fiscal Year: 2016
  4. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2011
  5. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory J del Zoppo; Fiscal Year: 2010
  6. Carla M Koehler; Fiscal Year: 2016
  7. Colin Thorpe; Fiscal Year: 2016
  8. Mechanisms of Alcoholic Liver Disease
    Chandrashekhar R Gandhi; Fiscal Year: 2013
  9. A Model Organism to Study Allorecognition and Chimerism
    Fadi Lakkis; Fiscal Year: 2009
  10. FUNCTION OF THE SUBUNITS OF EUKARYOTIC CHROMOSOMES
    WILLIAM GARRARD; Fiscal Year: 2013

Detail Information

Publications272 found, 100 shown here

  1. ncbi IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni
    S C Bosshardt
    Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
    Parasite Immunol 19:347-53. 1997
    ..level infections with Schistosoma mansoni, approximately 20% of male CBA/J mice develop hypersplenomegaly syndrome (HSS) while the rest present with moderate splenomegaly syndrome (MSS)...
  2. ncbi Expression of alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli and molecular characterization of the recombinant alanine racemase
    Tadao Oikawa
    Department of Biotechnology, Faculty of Engineering, Kansai University, 3 3 35 Yamate cho, Suita, Osaka Fu 564 8680, Japan
    J Biotechnol 125:503-12. 2006
    We constructed the high-expression system of the alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli BL 21 (DE3) to characterize the enzymological and structural properties of the gene product, Alr...
  3. ncbi Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway
    Chengrong Lu
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, Beijing 100850, P R China
    FASEB J 16:90-2. 2002
    Many growth factors and cytokines are involved in liver regeneration. Of them, only hepatopoietin (HPO)/ALR (augmenter of liver regeneration) is a specifically hepatotrophic factor originally identified from the cytosol of regenerating ..
  4. ncbi Augmenter of liver regeneration: its place in the universe of hepatic growth factors
    A Francavilla
    Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213
    Hepatology 20:747-57. 1994
  5. ncbi Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription
    Yong Li
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center, China
    Eur J Biochem 269:3888-93. 2002
    Hepatopoietin (HPO) is a novel human hepatotrophic growth factor...
  6. pmc Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes
    Chinnasamy Thirunavukkarasu
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, E 1542 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Hepatol 48:578-88. 2008
    Augmenter of liver regeneration (ALR), a protein synthesized and stored in hepatocytes, is associated with mitochondria, and possesses sulfhydryl oxidase and cytochrome c reductase activities...
  7. pmc Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space
    Vidyadhar N Daithankar
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    Biochemistry 48:4828-37. 2009
    Augmenter of liver regeneration (ALR) is both a growth factor and a sulfhydryl oxidase that binds FAD in an unusual helix-rich domain containing a redox-active CxxC disulfide proximal to the flavin ring...
  8. pmc The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency
    Alessio Di Fonzo
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, 20122 Milan, Italy
    Am J Hum Genet 84:594-604. 2009
    ..The role of the human Erv1 ortholog, GFER, in the DRS has been poorly explored...
  9. doi Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Free Radic Biol Med 47:1057-66. 2009
    ..Overexpression of ALR significantly increased the mitochondrial membrane potential, inhibited cytochrome c release, and opposed the loss ..
  10. doi Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
    Lorenzo Polimeno
    Section of Gastroenterology, Department of Emergency and Organ Transplantation DETO, University of Bari, Bari, Italy
    Free Radic Res 43:865-75. 2009
    ..Disulphide bridges formation is catalysed by sulphydryl oxidase enzymes...
  11. pmc Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR
    Lucia Banci
    Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, 50019 Florence, Italy
    Proc Natl Acad Sci U S A 108:4811-6. 2011
    ..reduced and regenerated to a functional state through the interaction with the flavin-dependent sulfhydryl oxidase ALR. Here we present the mechanistic basis of ALR-MIA40 interaction at atomic resolution by biochemical and structural ..
  12. pmc A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
    T G Senkevich
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:12068-73. 2000
    Proteins of the ERV1/ALR family are encoded by all eukaryotes and cytoplasmic DNA viruses for which substantial sequence information is available. Nevertheless, the roles of these proteins are imprecisely known...
  13. ncbi Beneficial effect of indapamide in experimental myocardial ischemia
    F R Boucher
    Laboratoire de Physiologie Cellulaire Cardiaque, , Grenoble, France
    Am J Hypertens 5:22-5. 1992
    ..after 15 min of reperfusion was significantly reduced; 3) the myocardial content of organic hydroperoxides (HPO), taken as an index of lipid peroxidation, was significantly lowered, whereas the activity of superoxide dismutase (..
  14. ncbi A mutant for the yeast scERV1 gene displays a new defect in mitochondrial morphology and distribution
    D Becher
    , , Jahnstrasse 15a, 17487 Greifswald, Germany
    Yeast 15:1171-81. 1999
    ..The homologous mammalian ALR(Augmenter of Liver Regeneration) genes from man, mouse and rat are important at different developmental stages of ..
  15. ncbi Alpha-chymotrypsin catalysis in imidazolium-based ionic liquids
    J A Laszlo
    New Crops and Processing Research, USDA-ARS, National Center for Agricultural Utilization Research, 1815 N. University St, Peoria, IL 61604 USA
    Biotechnol Bioeng 75:181-6. 2001
    ..alpha-Chymotrypsin freeze-dried with K(2)HPO(4), KCl, or poly(ethylene glycol) demonstrated no activity in [bmim][PF(6)] or [omim][PF(6)] at very low water ..
  16. doi Behaviour and dynamics of di-ammonium phosphate in bauxite processing residue sand in Western Australia--I. NH3 volatilisation and residual nitrogen availability
    C R Chen
    Environmental Futures Centre and Griffith School of Environment, Griffith University, Nathan, Queensland, 4111, Australia
    Environ Sci Pollut Res Int 17:1098-109. 2010
    ..Alcoa currently applies 2.7 t ha(-1) of di-ammonium phosphate ((NH(4))(2)HPO(4); DAP)-based fertiliser as a part of rehabilitation of the outer residue sand embankments of its RDAs...
  17. ncbi [Anti-virus effect of hepatocyte stimulating substance (HSS) on duck hepatitis B virus in vivo]
    G Chen
    The 302 Hospital of PLA, Beijing 100039
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:329-32. 1997
    ..day old Beijing ducklings infected by duck hepatitis B virus as experimental model to observe anti-virus effect of HSS. Beijing ducklings hatched within one day were injected intravenously with duck hepatitis B virus (DHBV)...
  18. ncbi Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase
    T Lisowsky
    Botanisches Institut, Henrich Heine Universität Düsseldorf, Germany
    Dig Liver Dis 33:173-80. 2001
    ....
  19. ncbi [Bronchial carcinoma associated with pulmonary osteoarthropathy (Marie-Bamberger)]
    W Pankow
    ,
    Pneumologie 44:1306-11. 1990
    Hypertrophic pulmonary osteoarthropathy (HPO) is characterised by clubbed, or drumstick, fingers and a painful periostitis of the extremities, and occurs most frequently as paraneoplastic symptom in association with bronchial carcinoma...
  20. ncbi Determination of inorganic anions by ion chromatography using a graphitized carbon column dynamically coated with cetyltrimethylammonium ions
    H Nagashima
    Institute of Science and Technology, Inc, Tokyo, Japan
    J Chromatogr A 855:261-6. 1999
    ..in the eluent were examined to optimize the separation of seven common anions (F-, Cl-, NO2-, Br-, NO3-, HPO(4)2- and SO(4)2-). Calibration curves were linear from 0.5 to 5 micrograms/ml for F-, from 1...
  21. ncbi Differential response of retinoic acid pretreated human synovial sarcoma cell line to anticancer drugs
    M Adwankar
    Chemotherapy Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 77:391-4. 1991
    The response of tumorigenic human synovial sarcoma (HSS) cell line to 10(-5)M optimum concentration of retinoic acid (RA) included changes in morphology, growth rate, suppression of anchorage-independent growth, induction of high ..
  22. ncbi [Medin modular implant for total knee arthroplasty--mid-term results]
    P Vavrik
    I ortopedická klinika 1 LF UK a FN Motol, Praha
    Acta Chir Orthop Traumatol Cech 76:30-4. 2009
    ..Pain, range of motion, stability and function were scored on a 100-point scale of the Hospital for Special Surgery (HSS) Scoring System. Subjective satisfaction was essessed by the patient's willingness to undergo the surgery again...
  23. ncbi Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
    Pharmacogenet Genomics 16:297-306. 2006
    ..causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)...
  24. pmc An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine
    T Lewis
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 74:1275-85. 2000
    The African swine fever virus (ASFV) genome contains a gene, 9GL, with similarity to yeast ERV1 and ALR genes. ERV1 has been shown to function in oxidative phosphorylation and in cell growth, while ALR has hepatotrophic activity...
  25. doi Equimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressure
    Gilles Francony
    Department of Anesthesiology and Critical Care, Albert Michallon Hospital, Grenoble, France
    Crit Care Med 36:795-800. 2008
    To compare the effects of equimolar doses of 20% mannitol solution and of 7.45% hypertonic saline solution (HSS) in the treatment of patients with sustained elevated intracranial pressure (ICP).
  26. doi Time-dependent alginate/polyvinyl alcohol hydrogels as injectable cell carriers
    Sang Ho Cho
    Department of Advanced Materials, Hannam University, 461 6 Jeonmin Dong, Yuseong Gu, Daejeon 305 811, South Korea
    J Biomater Sci Polym Ed 20:863-76. 2009
    ..alcohol (PVA) blend hydrogels with controllable gelation rate by using CaSO(4) as a cross-linking agent and Na(2)HPO(4) as a cross-linking retardation agent...
  27. ncbi Effects of small- and large-volume resuscitation on coagulation and electrolytes during experimental endotoxemia in anesthetized horses
    Lucas G Pantaleon
    Marion duPont Scott Equine Medical Center, Virginia Maryland Regional College of Veterinary Medicine, Leesburg, VA, USA
    J Vet Intern Med 21:1374-9. 2007
    ..of a larger project, the objective of this study was to determine the effects of SVR (hypertonic saline solution [HSS] plus hetastarch [HES]) on coagulation and serum electrolytes concentration, and to compare SVR with large- and ..
  28. doi Impairment of D-alanine biosynthesis in Mycobacterium smegmatis determines decreased intracellular survival in human macrophages
    Ofelia Chacon
    Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, NE 68583, USA
    Microbiology 155:1440-50. 2009
    ..in eubacteria is the enantiomeric conversion from l-alanine, a reaction catalysed by d-alanine racemase (Alr)...
  29. ncbi Radiotherapy in painful heel spurs (plantar fasciitis)--results of a national patterns of care study
    Oliver Micke
    Department of Radiotherapy, Munster University Hospital, Munster, Germany
    Int J Radiat Oncol Biol Phys 58:828-43. 2004
    After a general patterns of care study, the German Cooperative Group on Radiotherapy for Benign Diseases conducted a multicenter cohort study to analyze radiotherapy (RT) in painful heel spur syndrome (HSS).
  30. ncbi Targeting enzymes involved in spermidine metabolism of parasitic protozoa--a possible new strategy for anti-parasitic treatment
    A Kaiser
    Institute for Medical Parasitology, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Parasitol Res 91:508-16. 2003
    ..falciparum, i.e. deoxyhypusine synthase (DHS; EC 1.1.1.249) and homospermidine synthase (HSS; EC 2.5.1.45)...
  31. pmc Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation
    Geoffrey K Kilili
    Molecular Cardiology Research Institute, Tufts Medical Center, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 285:15076-87. 2010
    ..Studies of Drosophila suggest that Hippo (hpo) is required for inhibition of cell proliferation mediated by dMer, the orthologue of human merlin...
  32. ncbi A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes
    Rimtautas Gudas
    Department of Orthopaedics and Trauma, Kaunas University Hospital, Kaunas, Lithuania
    Arthroscopy 21:1066-75. 2005
    ....
  33. ncbi [Balancing of soft tissues in total knee arthroplasty for patients with rheumatoid arthritis with knee flexion contracture]
    Weijun Wang
    Department of Clinical Medicine, Ningxia Medical College School, Yinchuan Ningxia 750004, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:1173-6. 2008
    ..To explore the technique of the soft tissue balancing in the total knee arthroplasty (TKA) for the patients of rheumatoid arthritis with flexion contracture...
  34. ncbi Iridium Ziegler-type hydrogenation catalysts made from [(1,5-COD)Ir(mu-O2C8H15)](2) and AlEt3: spectroscopic and kinetic evidence for the Ir(n) species present and for nanoparticles as the fastest catalyst
    William M Alley
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    Inorg Chem 49:8131-47. 2010
    Ziegler-type hydrogenation catalysts, those made from a group 8-10 transition metal precatalyst and an AlR(3) cocatalyst, are often used for large scale industrial polymer hydrogenation; note that Ziegler-type hydrogenation catalysts are ..
  35. ncbi Nucleation and elongation of actin filaments in the presence of high speed supernate from neutrophil lysates: modulating effects of Ca2+ and phosphatidylinositol-4,5-bisphosphate
    M J DiNubile
    Division of Infectious Diseases, Department of Medicine, Cooper Health System, UMDNJ Robert Wood Johnson Medical School, Camden, NJ, USA
    Biochim Biophys Acta 1405:85-98. 1998
    ..High speed supernates (HSS) of dilute neutrophil lysates contain actin monomers and/or oligomers that can be induced to polymerize by certain ..
  36. ncbi Shelf lives of aseptically prepared medicines--stability of hydrocortisone sodium succinate in PVC and non-PVC bags and in polypropylene syringes
    Diane Clare Rigge
    Quality Control North West, Stepping Hill Hospital, Poplar Grove, Stockport, Cheshire SK2 7JE, UK
    J Pharm Biomed Anal 38:332-6. 2005
    Parenteral aseptic preparations of hydrocortisone sodium succinate (HSS) are used frequently in hospitals, but little definitive stability information is available...
  37. ncbi Cardiovascular and pulmonary effects of hetastarch plus hypertonic saline solutions during experimental endotoxemia in anesthetized horses
    Lucas G Pantaleon
    Marion duPont Scott Equine Medical Center, Virginia Maryland Regional College of Veterinary Medicine, Leesburg, VA, USA
    J Vet Intern Med 20:1422-8. 2006
    ..The objective of this study was to determine the cardiopulmonary effects of small-volume resuscitation using hypertonic saline solution (HSS) plus Hetastarch (HES) during experimental endotoxemia in anesthetized horses.
  38. doi Monitoring stress levels in postgraduate medical training
    Justin D Hill
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1078, USA
    Laryngoscope 119:75-8. 2009
    ..and a low degree of personal accomplishment using the Maslach Burnout Inventory-Human Services Survey (MBI-HSS)...
  39. ncbi Five percent, 7.5% or 10% hypertonic saline prevents delayed neuronal death in gerbils
    Shinsuke Hamaguchi
    Department of Anesthesiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Can J Anaesth 49:745-8. 2002
    To clarify the appropriate concentration and dose of hypertonic saline solution (HSS) for preventing delayed neuronal death in the hippocampal CA1 subfield after transient forebrain ischemia in gerbils.
  40. ncbi The influence of limited postoperative weight-bearing on the outcome of drilling in osteochondritis dissecans tali
    Michael Bohnsack
    Department of Orthopedic Surgery, Hannover Medical School, Anna von Borries Str 1 7, 30625 Hannover, Germany
    Arch Orthop Trauma Surg 123:447-50. 2003
    ..This prospective study was performed to assess the influence of limited weight-bearing on the outcome of osteochondral drilling in the treatment of an osteochondritis dissecans tali...
  41. pmc Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
    Dalei Wu
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People s Republic of China
    Protein Sci 17:1066-76. 2008
    Alanine racemase (Alr) is an important enzyme that catalyzes the interconversion of L-alanine and D-alanine, an essential building block in the peptidoglycan biosynthesis...
  42. doi Effect of specific anion on templated crystal nucleation at the liquid-liquid interface
    Sunghee Lee
    Department of Chemistry, Iona College, New Rochelle, New York 10801, USA
    Langmuir 26:9556-64. 2010
    ..The salts used were K(2)HPO(4), KCl, KBr, KI, KNO(3), and KSCN, present at an initial concentration of 10 mM within an aqueous microdroplet ..
  43. ncbi Hallermann-Streiff syndrome associated with small cerebellum, endocrinopathy and increased chromosomal breakage
    J W Hou
    Division of Medical Genetics and Metabolism, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Acta Paediatr 92:869-71. 2003
    Hallermann-Streiff syndrome (HSS) is a rare clinic entity of unknown aetiology. Further clinical and metabolic-genetic evaluations are indicated...
  44. pmc An intronic locus control region plays an essential role in the establishment of an autonomous hepatic chromatin domain for the human vitamin D-binding protein gene
    Tomoko Hiroki
    Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:7365-80. 2007
    ..A minimal hDBP transgene, containing a defined set of liver-specific DNase I hypersensitive sites (HSs), is robustly expressed in mouse liver in a copy-number-dependent manner. Here we evaluate these HSs for function...
  45. doi Pharmacokinetics of laropiprant and glucuronide metabolite in patients with severe renal insufficiency
    Mark Stroh
    Department of Clinical Drug Metabolism, Merck Research Laboratories, West Point, PA 19486 0004, USA
    Am J Ther 16:379-84. 2009
    ..laropiprant 40-mg dose in 8 nondialyzed, severe renal insufficiency patients (RIs) with healthy matched subjects (HSs) (24-hour creatinine clearance <30 mL/min/1.73 m(2) and >80 mL/min/1.73 m(2) for RIs and HSs, respectively)...
  46. doi Genetic recombinant expression and characterization of human augmenter of liver regeneration
    Chun fang Gao
    Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200438, China
    Dig Dis Sci 54:530-7. 2009
    ..To establish a highly effective prokaryotic recombinant expression system for human augmenter of liver regeneration (hALR) and to characterize the recombinant hALR both in vitro and in vivo...
  47. doi A glutathione-specific aldose reductase of Leishmania donovani and its potential implications for methylglyoxal detoxification pathway
    Jyoti Rath
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Gene 429:1-9. 2009
    ..The gene encoding aldose reductase (ALR) has been cloned from Leishmania donovani, a protozoan parasite causing visceral leishmaniasis...
  48. ncbi Structural analysis and mapping of DNase I hypersensitivity of HS5 of the beta-globin locus control region
    Q Li
    School of Medicine, University of Washington, Seattle, Washington, 98195, USA
    Genomics 61:183-93. 1999
    ..The LCR is composed of five DNase I hypersensitive sites (HSs), four of which are formed in erythroid cells. The function of the 5'-most site, HS5, remains unknown...
  49. ncbi Heterologous expression of a bacterial homospermidine synthase gene in transgenic tobacco: effects on the polyamine pathway
    Annette Kaiser
    Institut für Medizinische Parasitologie, Bonn, Germany
    Arch Pharm (Weinheim) 335:143-51. 2002
    Homospermidine synthase (HSS) is a branch-point enzyme that links the secondary pathway (pyrrolizidine alkaloids) to primary metabolism (polyamines)...
  50. doi Head, arm and trunk coordination during reaching in children
    H Sveistrup
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Exp Brain Res 188:237-47. 2008
    ..HST) or "en bloc" pattern was observed with approximately the same frequency as a head-stabilized-in-space (HSS) pattern in the youngest children in the yaw plane for reaches within arm's length...
  51. ncbi [Clinical analysis of 13 infected total knee replacements]
    B Kou
    Arthritis and Clinic Research Center, People's Hospital, Beijing Medical University, Beijing 100044, China
    Zhonghua Wai Ke Za Zhi 38:253-5. 2000
    ..The preoperative average ROM of knees was 55 degrees and the average Hospital for Special Surgery (HSS) knee score was 36.5 points. Clinical results were evaluated after average follow-up for 3 years and 5 months...
  52. ncbi [Anterior cruciate ligament reconstruction using periosteum wrapped autologous hamstring tendons: clinical research]
    Ran Sun
    Department of Orthopedic Surgery, Third Hosipital of Heibei Medical University, Shijiazhuang 050051, China
    Zhonghua Yi Xue Za Zhi 90:182-6. 2010
    ..To develop a surgical technique using a periosteal flap wrapped autologous hamstring tendons in ACL reconstruction and to examine its short-term outcome...
  53. ncbi Thyroid hormone and dietary carbohydrate interact to regulate rat liver S14 gene transcription and chromatin structure
    D B Jump
    Department of Physiology, Michigan State University, East Lansing 48824
    J Biol Chem 265:3474-8. 1990
    ..hypothyroid rats inhibited the formation of three DNase I-hypersensitive sites flanking the 5'-end of the S14 gene (Hss-1 at -65 to -265 base pairs; Hss-2 at -1.2 kilobases and Hss-3 at -2.67 kilobases)...
  54. ncbi Removal of dissolved organic matter by granular-activated carbon adsorption as a pretreatment to reverse osmosis of membrane bioreactor effluents
    Shirra Gur-Reznik
    Faculty of Civil and Environmental Engineering and Grand Water Research Institute, Technion Israel Institute of Technology, Haifa 32000, Israel
    Water Res 42:1595-605. 2008
    ..The pattern and efficiency of DOM adsorption and fate of the hydrophobic (HPO), transphilic (TPI) and hydrophilic (HPI) fractions were characterized, as well as their impact on organic fouling ..
  55. pmc Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat kupffer cells
    Chandrashekhar R Gandhi
    VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    J Cell Physiol 222:365-73. 2010
    Mitogenic effect of augmenter of liver regeneration (ALR), a protein produced and released by hepatocytes, on hepatocytes in vivo but not in vitro suggests that the effect is mediated by nonparenchymal cells...
  56. ncbi Persistent transforming growth factor-beta 1 expression may predict peritoneal fibrosis in CAPD patients with frequent peritonitis occurrence
    C Y Lin
    Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan
    Am J Nephrol 18:513-9. 1998
    ..before onset, once a week during peritonitis, and after peritonitis in high and low peritonitis occurrence (HPO and LPO) patients. Fifteen patients with a LPO rate and 5 patients with a HPO rate were followed up longitudinally...
  57. ncbi Reactivity and selectivity of the N-acetyl-Glu-P-1, N-acetyl-Glu-P-2, N-acetyl-MeIQx, and N-acetyl-IQx nitrenium ions: comparison to carbocyclic N-arylnitrenium ions
    Michael Novak
    Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, USA
    J Am Chem Soc 124:7972-81. 2002
    ..The reactions of the nitrenium ions with AcO(-), HPO(4)(2-), N(3)(-), and 2'-deoxyguanosine (d-G) were characterized in aqueous solution by using a combination of ..
  58. ncbi Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite
    Tunhan Chang
    Division of Biological Chemistry and Molecular Microbiology, The Wellcome Trust Biocentre, The School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 277:50176-82. 2002
    ..anchor biosynthesis in all eukaryotes is the conversion of D-GlcNAcalpha1-6-d-myo-inositol-1-HPO(4)-sn-1,2-diacylglycerol (GlcNAc-PI) to d-GlcNalpha1-6-d-myo-inositol-1-HPO(4)-sn-1,2-diacylglycerol by GlcNAc-PI ..
  59. ncbi Intra-articular fractures of the distal femur: a long-term follow-up study of surgically treated patients
    Maarten V Rademakers
    Department of Orthopaedic Surgery, Academic Medical Center, G4 259, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Orthop Trauma 18:213-9. 2004
    ..To analyze the long-term (5-25 years) functional and radiologic results of surgically treated intra-articular fractures of the distal femur...
  60. ncbi [Cloning, sequence analysis and expression of alanine racemase gene in Pseudomonas putida]
    Qin Cao
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Wei Sheng Wu Xue Bao 46:80-4. 2006
    ..DadX encodes a peptide of 357 amino acids with a calculated molecular weight of 38.82kDa. The putative product of alr gene is a peptide of 409 amino acids with molecular weight of 44.182kDa...
  61. doi Age and stress as determinants of the severity of hyperthyroidism caused by Graves' disease in newly diagnosed patients
    Xander G Vos
    Department of Endocrinology and Metabolism, F5 161, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 160:193-9. 2009
    ..We tested the hypothesis whether advancing age is associated with less exposure to stress, resulting in a lower immunological response, and less severe Graves' hyperthyroidism...
  62. doi Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity
    K Sartorius
    Section of Dermatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Br J Dermatol 161:831-9. 2009
    ..The disease is difficult to treat and has a severe impact on quality of life. A clinically relevant system for scoring disease severity is lacking in HS...
  63. doi Generation and characterization of thymidine/D-alanine auxotrophic recombinant Lactococcus lactis subsp. lactis IL1403 expressing BmpB
    Eun Bae Kim
    Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Curr Microbiol 61:29-36. 2010
    ..lactis subsp. lactis IL1403 strains expressing a heterologous protein, BmpB, using thyA- and alr-targeting integration vectors: ITD (thyA(-)alr(+) bmpB(+)), IAD (thyA(+)alr(-)bmpB(+)), and ITDAD (thyA(-)alr(-) ..
  64. ncbi [Comparison of short-term result between high-flex and conventional posterior-stabilized prosthesis in total knee arthroplasty]
    Jin Li
    Department of Orthopedics, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo Zhejiang, 315040, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:278-81. 2010
    ..To compare the short-term result between the high-flex (HF) and conventional posterior-stabilized (PS) prosthesis in total knee arthroplasty (TKA)...
  65. pmc Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy
    Vidyadhar N Daithankar
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    Biochemistry 49:6737-45. 2010
    The sulfhydryl oxidase augmenter of liver regeneration (ALR) binds FAD in a helix-rich domain that presents a CxxC disulfide proximal to the isoalloxazine ring of the flavin...
  66. doi The effect of pressure on the phase transition behavior of tridecane, pentadecane, and heptadecane: a Fourier transform infrared spectroscopy study
    Motoi Yamashita
    College of Pharmaceutical Sciences, Ritsumeikan University, 1 1 1 Noji higashi, Kusatsu, Shiga 525 8577, Japan
    J Chem Phys 134:144503. 2011
    ..The transition between the high pressure ordered (HPO) and high pressure rotator (HPR) phases has been observed in the pressure ranges of 270-220, 106-95, and 152-181 ..
  67. doi Characterization of biofilm formation on a humic material
    A L Rodrigues
    Institute for Biotechnology and Bioengineering IBB, Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4700 057, Braga, Portugal
    J Ind Microbiol Biotechnol 35:1269-76. 2008
    ..The present work intends to study biofilm formation in the presence of humic substances (HSs) as a carbon source...
  68. ncbi Systematic prediction of new inorganic ferroelectrics in point group 4
    - Abrahams
    Physics Department, Southern Oregon University, Ashland, OR 97520, USA
    Acta Crystallogr B 55:494-506. 1999
    ..modulated NbTe(4), Na(3)Nb(12)O(31)F, Ca(2)FeO(3)Cl, K(4)CuV(5)O(15)Cl, TlBO(2), CrOF(3), PbTeO(3), VO(HPO(3))(H(2)O).3H(2)O, MgB(2)O(OH)(6), beta-tetragonal boron, CuBi(2)O(4), WOBr(4), Na(8)PtO(6), SbF(2)Cl(3), Ba(1...
  69. ncbi An erythroid-specific chromatin opening element reorganizes beta-globin promoter chromatin structure and augments gene expression
    M J Nemeth
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Blood Cells Mol Dis 27:767-80. 2001
    ..Changes include the formation of DNase I hypersensitive sites (HSs) over the promoters of actively expressed genes...
  70. ncbi Reduced thymic expression of islet antigen contributes to loss of self-tolerance
    C E Mathews
    Department of Pediatrics, University of Pittsburgh, and Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann N Y Acad Sci 1005:412-7. 2003
    ..that the expression of GAD65, GAD67, and INS2 were equivalent when comparing NOD at any age to B6, BALB/cJ, and ALR/LtJ...
  71. pmc A novel assay method for an amino acid racemase reaction based on circular dichroism
    Masafumi Noda
    Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Hiroshima 734 8551, Japan
    Biochem J 389:491-6. 2005
    ..based on circular dichroism that can be used for the kinetic study of the activity of amino acid racemases, such as ALR (alanine racemase)...
  72. ncbi Preliminary results after total knee arthroplasty without femoral trochlea: evaluation of clinical results, quality of life and gait function
    Susanne Fuchs
    Department of Orthopaedics, University Hospital Muenster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Knee Surg Sports Traumatol Arthrosc 13:664-9. 2005
    ..The clinical results were evaluated with the Hospital for Special Surgery Scores (HSS) and the Knee Society Clinical Rating Systems (KSS). Pain was rated on a Visual Analog Scale (VAS)...
  73. ncbi Families' perceptions of services in assisted living residences
    Cynthia A Beel-Bates
    Cook DeVos Health Sciences Center, Kirkhof College of Nursing, Grand Valley State University, Grand Rapids, Michigan 49503, USA
    J Gerontol Nurs 33:5-12. 2007
    ..A total of 46 respondents reported assistance with activities of daily living as the most frequently offered ALR service...
  74. doi The disulfide relay of the intermembrane space of mitochondria: an oxygen-sensing system?
    Karl Bihlmaier
    Cell Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Ann N Y Acad Sci 1147:293-302. 2008
    ..Import of these proteins is catalyzed by two essential components, Mia40 and Erv1. Mia40 is a protein in the intermembrane space that directly binds newly imported proteins via disulfide bonds...
  75. doi Weight-bearing flexion angle correlates significantly with severity of knee osteoarthritis
    Yuji Kuroyanagi
    Department of Orthopedic Surgery, Keio University, Tokyo, Japan
    Knee 16:371-4. 2009
    ..Maximum flexion angles during weight-bearing rising correlated significantly with HSS score (r=0.63; 95% confidence interval, 0.40-0...
  76. ncbi Rapid assay of trace ceruloplasmin using an immunonanogold resonance scattering spectral probe
    Zhiliang Jiang
    School of Environment and Resource, Guangxi Normal University, Guilin 541004, China
    Anal Sci 25:463-7. 2009
    ..In a pH 7.8 citric acid-Na(2)HPO(4) buffer solution and in the presence of polyethylene glycol (PEG), an immunoreaction between AuGCP and CP took ..
  77. doi ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus
    Vasiliki Papadopoulou
    Department of Haematology, Imperial College London, Hammersmith Hospital, UK
    Biochem J 427:541-50. 2010
    ..4 kb upstream of BCL6 transcription initiation (HSS-4...
  78. doi The human phenotype ontology
    P N Robinson
    Institute for Medical Genetics, Augustenburger Platz 1, 13353 Berlin, Germany
    Clin Genet 77:525-34. 2010
    ..The Human Phenotype Ontology (HPO) is being developed in an effort to provide such a vocabulary...
  79. doi Trapping oxidative folding intermediates during translocation to the intermembrane space of mitochondria: in vivo and in vitro studies
    Dionisia P Sideris
    Department of Biology, University of Crete and Institute of Molecular Biology and Biotechnology Foundation for Research and Technology Hellas, Heraklion, Crete, Greece
    Methods Mol Biol 619:411-23. 2010
    ..in the IMS by a disulfide relay mechanism that involves introduction of disulfides from the sulfhydryl oxidase Erv1 to the redox-regulated import receptor Mia40 and then on to the substrate...
  80. doi Anodic mesoporous TiO2 layer on Ti for enhanced formation of biomimetic hydroxyapatite
    Tuli Dey
    Department of Materials Science, WW4 LKO, University of Erlangen Nuremberg, Erlangen, Germany
    Acta Biomater 7:1873-9. 2011
    ..These coatings are produced by anodization of Ti at elevated temperature in a glycerol/K(2)HPO(4) electrolyte, followed by an appropriate etching process...
  81. doi Meta-analysis and systematic review of clinical outcomes comparing mobile bearing and fixed bearing total knee arthroplasty
    Holly Smith
    Division of Orthopaedic Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Arthroplasty 26:1205-13. 2011
    ..We also pooled data for post-operative range of motion (ROM) and Hospital for Special Surgery scores (HSS). The standard difference in mean outcome scores for KSS and HSS demonstrated no difference between groups (P = ...
  82. doi Crystal forms of naproxen
    Jung Soon Song
    College of Pharmacy, Duksung Women s University, Seoul, Korea
    Arch Pharm Res 34:87-90. 2011
    ..2)H(2)O/20°C) and 95% RH (saturated solution of Na(2)HPO(4)/20°C), Form 2 and Form 4 were transformed to Form 1, but Form 3 and Form 1 were not transformed and they were ..
  83. doi Gene expression analysis of demineralized bone matrix-induced osteogenesis in human periosteal cells using cDNA array technology
    S Honsawek
    Department of Biochemistry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Thai Red Cross Society, Bangkok, Thailand
    Genet Mol Res 10:2093-103. 2011
    ..We investigated gene expression patterns of osteogenic differentiation in human periosteal (HPO) cells cultured with demineralized bone matrix, using cDNA array technology...
  84. doi Ion permeable microcapsules for the release of biologically available ions for remineralization
    Michael T Davidson
    Department of Chemistry, College of Arts and Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Biomed Mater Res A 100:665-72. 2012
    ..polymerization technique was utilized to prepare microcapsules containing either an aqueous solution of K₂HPO₄, Ca(NO₃)₂, or NaF...
  85. doi Sedimentary transport and fate of polycyclic aromatic hydrocarbons (PAH) from managed burning of moorland vegetation on a blanket peat, South Yorkshire, UK
    Christopher H Vane
    British Geological Survey, Environmental Science Centre, Keyworth, Nottingham, NG12 5GG, UK
    Sci Total Environ 449:81-94. 2013
    ..vegetation and compares them to PAH in catchment vegetation, underlying peats, head water suspended sediment (HSS), stream water and reservoir sediment cores...
  86. ncbi Hip-specific quality of life survey for patients with hip osteoarthritis - development and preliminary validity assessment
    Wiesław Kaczmarek
    Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, Poznan, Poland
    Pol Orthop Traumatol 79:10-8. 2014
    ..Aim. Development and preliminary validation of hip-specific quality of life survey (HSS) of patients with hip osteoarthritis.
  87. doi Urinary glycosaminoglycan (uGAG) excretion in healthy pediatric and adolescent population
    Katarzyna Komosinska-Vassev
    Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, Poland Electronic address
    Clin Biochem 47:1341-3. 2014
    ..on the urinary excretion of total glycosaminoglycans (uGAGs) and their particular types: chondroitin/dermatan sulfates (CS/DSs), heparan sulfates (HSs) and hyaluronan (HA) was analyzed in healthy pediatric and adolescent population.
  88. doi Determination and pharmacokinetic study of four lignans in rat plasma after oral administration of an extract of Valeriana amurensis by ultra-high performance liquid chromatography with tandem mass spectrometry
    Juan Xue
    Key Laboratory of Chinese Materia Medica Ministry of Education, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin, 150040, China
    J Sep Sci 39:1825-33. 2016
    ..The analytes and ethyl 4-hydroxybenzoate (internal standard) were separated on a Waters ACQUITY UPLC HSS T3 chromatographic column...
  89. pmc Spermidine Inversely Influences Surface Interactions and Planktonic Growth in Agrobacterium tumefaciens
    Yi Wang
    Department of Biology, Indiana University, Bloomington, Indiana, USA
    J Bacteriol 198:2682-91. 2016
    ..of the precursors putrescine and carboxyspermidine in the CASDH and CASDC mutants, respectively, but unexpectedly, both mutants accumulated homospermidine; here, we show that this requires a homospermidine synthase (hss) homologue.
  90. doi Can we replace HIV sentinel surveillance platform with prevention of parent-to-child transmission (PPTCT) program data to assess HIV burden and trends in India?
    Rajneesh K Joshi
    Department of Epidemiology and Biostatistics, National AIDS Research Institute ICMR, 73, G Block MIDC Bhosari, Pune 411026, Maharashtra, India Faculty of Health and Biomedical Sciences, Symbiosis International University, Pune, Maharashtra, India
    Trans R Soc Trop Med Hyg 110:393-9. 2016
    Estimates of HIV burden in India are based on HIV sentinel surveillance (HSS), which has limitations such as insufficient sample size for district level analysis and ethical concerns...
  91. doi UHPLC-Q-TOF-MS-based metabolomics approach to compare the saponin compositions of Xueshuantong Injection and Xuesaitong Injection
    Changliang Yao
    Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, China
    J Sep Sci . 2016
    ..A highly efficient chromatographic separation was achieved on an HSS T3 column within 20 min with the holistic metabolites information recorded in the negative MSE mode...
  92. ncbi Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
    L Madisen
    Hutchinson Cancer Center, University of Washington School of Medicine, Seattle 98104
    Genes Dev 8:2212-26. 1994
    ..3' of the IgH C alpha gene contains four tissue-specific and cell stage-specific DNase I hypersensitive sites (HSs), two of which map to the late B cell-specific 3' C alpha enhancer...
  93. ncbi Explosion investigation of asphalt-salt mixtures in a reprocessing plant
    K Hasegawa
    National Research Institute of Fire and Disaster 14 1, Nakahara 3 Chome, Mitaka, 181 8633, Tokyo, Japan
    J Hazard Mater 79:241-67. 2000
    ..Molecules containing intramolecular hydrogen, such as Na(2)HPO(4) and NaHCO(3), do not oxidize asphalt directly, however, their presence chemically promotes the oxidizing ..
  94. ncbi Short-term environmental impact of clam dredging in coastal waters (south of Portugal): chemical disturbance and subsequent recovery of seabed
    M Falcao
    Instituto Nacional de Investigação Agrária e das Pescas INIAP IPIMAR, Centro Regional de Investigação Pesqueira do Sul CRIPSul, Av 5 de Outubro s n, 8700 305 Olhão, Portugal
    Mar Environ Res 56:649-64. 2003
    ..A microcosm experiment showed that after sediment disturbance HPO(4)(2-) dissolved in pore water decreased from 40 to 10 microM being simultaneously sorbed onto iron oxides formed ..
  95. pmc Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
    Michael Overholtzer
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:12405-10. 2006
    ..one known gene, Yap, encoding the mammalian ortholog of Drosophila Yorkie (Yki), a downstream effector of the Hippo(Hpo)-Salvador(Sav)-Warts(Wts) signaling cascade, recently identified in flies as a critical regulator of cellular ..
  96. ncbi Clinical results of posterior cruciate ligament retaining TKA with alumina ceramic condylar prosthesis: comparison to Co-Cr alloy prosthesis
    Tokifumi Majima
    Department of Orthopaedic Surgery, Hokkaido University School of Medicine, N 15, W 7, Kita ku, Sapporo, 060 8631, Japan
    Knee Surg Sports Traumatol Arthrosc 16:152-6. 2008
    ..In the other patients, there were no significant differences in clinical parameters (HSS knee score and range of motion) between the two prostheses...
  97. doi Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells
    Christian Dombrowski
    Stem Cells and Tissue Repair Group, Institute of Medical Biology, A STAR, Singapore
    Stem Cells Dev 18:661-70. 2009
    ..cells (MSCs) is controlled by various growth factors, the activities of which can be modulated by heparan sulfates (HSs)...
  98. ncbi Patient-based outcomes in patellofemoral arthroplasty
    M M Utukuri
    Royal Free Hospital, UK
    J Knee Surg 21:269-74. 2008
    ..Clinical and radiographic assessment was performed using the Hospital for Special Surgery (HSS) knee score...
  99. doi Biofilms formed on humic substances: response to flow conditions and carbon concentrations
    A L Rodrigues
    IBB Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Bioresour Technol 101:6888-94. 2010
    ..Thus, the aim of this study was to investigate the response of biofilms formed with and without humic substances (HSs) to an increase in flow velocity (0.04-0.10 ms(-1)) and HSs concentration (9.7+/-1.0 to 19.8+/-0.4 mgL(-1) C)...
  100. doi Sequential changes in chromatin structure during transcriptional activation in the beta globin LCR and its target gene
    Kihoon Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609 735, Republic of Korea
    Int J Biochem Cell Biol 42:1517-24. 2010
    ..of the globin genes requires the locus control region (LCR) consisting of several hypersensitive sites (HSs)...
  101. doi Comparison of dissolved organic matter fractions in a secondary effluent and a natural water
    Shuang Xue
    School of Environmental Science, Liaoning University, Shenyang 110036, China
    Environ Monit Assess 180:371-83. 2011
    ..DOM was fractionated using XAD resins into five fractions: hydrophobic acid (HPO-A), hydrophobic neutral (HPO-N), transphilic acid (TPI-A), transphilic neutral (TPI-N) and hydrophilic fraction (..

Research Grants71

  1. Characterization of redox-mediated protein in mitochondria
    SONYA ELINA NEAL; Fiscal Year: 2013
    ..The sulfhydryl oxidase Erv1 also functions in this pathway as a putative oxidant for Mia40...
  2. Clayton E Mathews; Fiscal Year: 2015
    ..with protection from T1D in both an at risk human population and in crosses of the T1D-prone NOD with T1D-resistant ALR mice. The goal of this application is to understand how this single amino acid change modifies resistance to T1D...
  3. Duojia Pan; Fiscal Year: 2016
    ..last project period has allowed us to delineate a Hippo kinase cascade comprised of the Ste20-like kinase Hippo (Hpo), the NDR family kinase Warts (Wts), and the transcriptional co activator Yorkie (Yki)...
  4. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2011
    ..with protection from T1D in both an at risk human population and in crosses of the T1D-prone NOD with T1D-resistant ALR mice. The goal of this application is to understand how this single amino acid change modifies resistance to T1D...
  5. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory J del Zoppo; Fiscal Year: 2010
    ..data, we propose that enzymes which degrade matrix heparan sulfate proteoglycans (HSPGs) and heparan sulfates (HSs) are generated following MCA:O, simultaneously with the matrix metalloproteinase pro-MMP-2, and are responsible for ..
  6. Carla M Koehler; Fiscal Year: 2016
    ..The TIM22 import pathway and the Erv1/Mia40 oxidative folding pathway will be targeted...
  7. Colin Thorpe; Fiscal Year: 2016
    ..and a representative of the smaller single-domain Erv-like oxidases, augmenter of liver regeneration (ALR)...
  8. Mechanisms of Alcoholic Liver Disease
    Chandrashekhar R Gandhi; Fiscal Year: 2013
    ..Our work using a mouse model of hepatic deficiency of a protein named augmenter of liver regeneration (ALR) indicates that the defects in ALR gene and serum ALR levels could be reliable diagnostic indicators of the ..
  9. A Model Organism to Study Allorecognition and Chimerism
    Fadi Lakkis; Fiscal Year: 2009
    ..The specific aims of the current proposal are to (1) functionally characterize alr genes, gene products, and interacting proteins;(2) further the genetic characterization of Hydractinia ..
  10. FUNCTION OF THE SUBUNITS OF EUKARYOTIC CHROMOSOMES
    WILLIAM GARRARD; Fiscal Year: 2013
    ..regions in Ig: chromatin that contain B-cell-specific and developmentally regulated DNase I hypersensitive sites (HSs): (1) A silencer (Sis) within the intervening sequence between the joining (J?) region and the most proximal V? ..
  11. Study of redox regulated pathways in the mitochondrion
    DEEPA VINAY DABIR; Fiscal Year: 2010
    ..cerevisiae). Key players in assembly of DDP1 are proteins Erv1, a sulfhydryl oxidase, and Mia40...
  12. JOSEPH KISSIL; Fiscal Year: 2016
    ..a a key regulator of multiple signal transduction pathways including those regulated by small G-proteins and the Hpo/Yap pathway...
  13. Contribution of Sigma Receptor Activation to Neuropathic Pain
    Hsiang En Wu; Fiscal Year: 2013
    ..The proposed studies will examine the central hypothesis that activation of alR receptors in nociceptive sensory neurons contributes to neuropathic and inflammatory pain through inhibition of ..
  14. Wu Min Deng; Fiscal Year: 2016
    ..have revealed that Notch is subject to strict temporal regulation by microRNAs and spatial regulation by the Hippo (Hpo) pathway...
  15. Cognitive Function in SLE (COGNITION)
    Robin L Brey; Fiscal Year: 2010
    ..Texas HSC at San Antonio (UTHSCSA), Johns Hopkins Medical Institutions (JHMI) and the Hospital for Special Surgery (HSS)...
  16. Ethel Cesarman; Fiscal Year: 2014
    ..Weill Cornell Medical College [WCMC], Sloan Kettering Institute [SKI], and Hospital for Special Surgery [HSS]) to provide a unique environment in which we strive to train the next generation of leaders in immunology and ..
  17. The Centers for Education and Research on Therapeutics *
    Alvin Mushlin; Fiscal Year: 2010
    ..Department of Public Health at Weill Medical College of Cornell University with the Hospital for Special Surgery (HSS), the largest and one of the most well-respected orthopedic institutions in the country...
  18. Kenneth H Moberg; Fiscal Year: 2015
    ..Our objectives in this proposal are to test the role of this newly discovered Crumbs-Hpo/Mst2 link in the excessive growth of tsg101 mutant tumors, and to identify novel components of the Crumbs-Hpo/Mst2 ..
  19. Eric P Skaar; Fiscal Year: 2016
    ..aureus machinery responsible for this adaptive response: the heme sensor system (Hss) and the heme regulated transporter (Hrt)...
  20. Joseph E Donnelly; Fiscal Year: 2016
    ..Although not specific to weight management HSS recommendations have been interpreted to be sufficient for that purpose...
  21. Public Reporting on Housing with Support Services for Aged and Disabled Consumers
    Sheryl Zimmerman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Housing with supportive services (HSS) is non-institutional housing with essential services (e.g...
  22. Marjolein C van der Meulen; Fiscal Year: 2016
    ..The Musculoskeletal Training Program represents the continued commitment of the Hospital for Special Surgery (HSS) to train clinicians and scientists in basic and applied research...
  23. Ada Hamosh; Fiscal Year: 2016
    ..data mining of OMIM, we have added 1CD9/10 and SNOMEDCT numbers to OMIM entries and plan to add UMLS, SNOMED, HPO and other ontology classifications to the features of OMIM's clinical synopses...
  24. Beth A Reboussin; Fiscal Year: 2016
    ..analysis (LTA) for studying empirically-derived stages of marijuana use and alternating logistic regressions (ALR) for estimating and modeling the magnitude of clustering in neighborhoods...
  25. MICHAEL H OVERHOLTZER; Fiscal Year: 2014
    ..as internalized cargo is degraded, which reminiscent of the recently described autophagic lysosome reformation (ALR) program that functions similarly during autophagy...
  26. A JEM 1400 Electron Microscope for a Core Facility
    Frederick R Maxfield; Fiscal Year: 2010
    ..This will enable the joint facilities to continue to meet the needs of the research faculties at both WCMC and HSS in future years without needing to invest in another large full-scale instrument.
  27. STRUCTURE OF ANTIMITOGENIC MESANGIAL HEPARAN SULFATES
    Aimin Wang; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) Heparan sulfates (HSs) and heparin, proposed as endogenous defending molecules in the "glomerular self-defense", are inhibitors of mesangial cell growth in human proliferative nephritides, in ..
  28. Mary K Crow; Fiscal Year: 2014
    ..by applicant): The objective of the Rheumatology Research Training Program at Hospital for Special Surgery (HSS) is to prepare outstanding physician and PhD candidates for 1) leadership positions in academic rheumatology and 2) ..
  29. MOLECULAR BASIS OF SYNDROMIC RETINITIS PIGMENTOSA
    Susan Hayflick; Fiscal Year: 1999
    ..Hallervorden-Spatz syndrome (HSS) and characterized by abnormal electroretinogram, lipofuscin accumulation in the retinal pigment epithelium, and ..
  30. Protein Modification by 3,4-Dihydroxyphenylacetaldehyde
    JONATHAN DOORN; Fiscal Year: 2006
    ..primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
  31. THE EFFECTS OF DEXAMETHASONE ON FOLLICULAR DEVELOPMENT
    LAURA ROCKWELL; Fiscal Year: 2001
    Interaction between the hypothalamic-pituitary-adrenal axis (HPA) and the hypothalamic-pituitary-ovarian axis (HPO) is well established but best understood at the level of the central nervous system (CNS) where the adrenal axis has an ..
  32. RISK-TAKING, ALCOHOL, AND HIV PREVENTION IN YOUTH
    Rick Zimmerman; Fiscal Year: 2003
    ..research, we expect that high school-age students who are high on sensation-seeking and impulsive decision-makers (HSS/IDM) will be particularly difficult to reach using conventional skills-based classroom curricula...
  33. Impact of Discordant Patient-Surgeon Expectations on Joint Arthroplasty Outcomes
    Hassan Ghomrawi; Fiscal Year: 2013
    ..This study will use data from the Hospital for Special Surgery (HSS) CERT TJA registry, which was established in 2007 with support from AHRQ and has thus far enrolled more than 8000 ..
  34. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
    ..The ALR mouse is closely related to NOD as evidenced by genetic identity for markers at multiple "Idd" (diabetes ..
  35. GROWTH FACTORS AND LIVER REGENERATION
    Sanjeev Gupta; Fiscal Year: 1993
    ..this proposal is to investigate the role of a putative liver-specific growth factor, hepatic stimulator substance (HSS), in liver regeneration and compare its effects with other mitogens, e.g...
  36. Clustering of underage alcohol use in communities and its contextual influences
    Beth Reboussin; Fiscal Year: 2009
    ..use based on pair wise odds ratios obtained from a statistical method called alternating logistic regression (ALR), (2) evaluate the role of individual, social and community-level environmental contexts on this clustering, and (3)..
  37. STUDY OF BIOMINERALIZATION MECHANISMS IN DENTIN
    Kostas Verdelis; Fiscal Year: 2004
    ..The sponsor and primary mentor is Dr. Boskey, Director of Research at HSS, with Dr. Crenshaw at the Dental Research Center of UNC as co-mentor...
  38. FIRST SCIENTIFIC WORKSHOP ON HALLERVORDEN-SPATZ SYNDROME
    Susan Hayflick; Fiscal Year: 2000
    Hallervorden-Spatz syndrome (HSS) is a rare autosomal recessive neurodegenerative disorder of childhood...
  39. SENSATION SEEKING AND DRUG ABUSE PREVENTION
    Lewis Donohew; Fiscal Year: 1993
    Approximately half of all adolescents and young adults can be classified as high sensation seekers (HSS)...
  40. Globin Gene Switching: Molecular Control
    George Stamatoyannopoulos; Fiscal Year: 2007
    ..goals of this proposal are to investigate the mechanisms of human hemoglobin switching, delineate the function of HSs of the LCR and develop a new approach for the study of the molecular and cellular control of human hemoglobin ..
  41. Regeneration and transdetermination of imaginal discs of Drosophila
    GEROLD A SCHUBIGER; Fiscal Year: 2010
    ..Furthermore, we identified putative regeneration genes such as alr-like, a gene orthologous to the mouse gene augmenter of liver regeneration (alr), Matrix metalloproteinase 1 (Mmp1),..
  42. Computational discovery of cis-regulatory sequences
    John Stamatoyannopoulos; Fiscal Year: 2007
    ..This will be achieved by precise localization of DNaseI hypersensitive sites (HSs) surrounding 100 erythroid-specific and 100 lymphoid lineage -restricted genes...
  43. MobileReminder: A Camera Phone Based Medication Reminder for Older Patients
    Huiping Li; Fiscal Year: 2006
    ..Compared with existing devices, such as Med-On Time, ALR, and the e-pill MED Timer, our camera-phone based solution will offer the following advantages: 1) camera phones ..
  44. Anand Krishnan; Fiscal Year: 2015
    ..Asscitino bochemca- fcrsokrs wih AR willb simtdi cse-cnrlmner rmwihi h chrt Cs efiiins t isigis aceril rom virl ALR will e evlpd n ese sig cliicl nd tillgic aacllctdfrmcmmnityan osialerlldAR css Micrbilprfiligwiha mhsis o eecin f ..
  45. Elucidating the Neurobiology of Postpartum Depression
    Eydie Moses Kolko; Fiscal Year: 2006
    ..Hypothalamic-pituitary-ovarian (HPO and hypothalamic-pituitary-adrenal (HPA) axis function will be assessed in relation to PET measures ..
  46. Identification of Functional DNA Elements by HSqPCR
    George Stamatoyannopoulos; Fiscal Year: 2006
    ..This profile will enable precise localization of all major Dnasel-hypersensitive sites ('HSs' hereafter)...
  47. Musculoskeletal Repair and Regeneration
    Adele L Boskey; Fiscal Year: 2010
    The theme of the Musculoskeletal Core Center at the Hospital for Special Surgery (HSS) is "Musculoskeletal Repair and Regeneration"...
  48. GENETIC ANALYSIS OF THE CHICKEN BETA-GLOBIN LOCUS
    Elliot Epner; Fiscal Year: 2004
    ..2. The role of the upstream hypersensitive sites (HSS) (5'HS1-4) in the chicken beta-globin locus will be investigated including the insulator boundary region (5'HS4)...
  49. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2005
    ....
  50. Contraceptive efficacy and body weight: Does obesity affect the risk of failure?
    Alison Edelman; Fiscal Year: 2007
    ..that increased Body Mass Index (BMI) alters OC availability resulting in inadequate hypothalamic-pituitary-ovarian (HPO) axis suppression during OC use in obese women...
  51. FUNCTION AND CONSERVATION IN GLOBIN LOCUS CONTROL REGION
    Ross Hardison; Fiscal Year: 2001
    ..LCR) is a major regulator of mammalian beta-like globin genes, and is marked by 5 DNase hypersensitive sites (HSs)...
  52. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  53. Understanding Emerging Patterns of Non-Daily Smoking: Field and Lab Assessments
    Saul Shiffman; Fiscal Year: 2010
    ....
  54. ROLE OF THE LCR IN HUMAN BETA-GLOBIN GENE REGULATION
    KENNETH PETERSON; Fiscal Year: 2001
    ..Specific Aim 3 will test the role of the LCR sequences in LCR complex formation and globin gene regulation using transgenic mice containing mutant beta-globin loci by applying FRET. ..
  55. Locus-linked Regulatory Motifs of Globin Gene Switching
    KENNETH PETERSON; Fiscal Year: 2008
    ..abstract_text> ..
  56. PATHOGENESIS OF FUNCTIONAL HYPOTHALAMIC AMENORRHEA
    Sarah Berga; Fiscal Year: 2001
    ..We expect that the results of this proposal will lead directly to the PA-91-lOO objective of developing a "psychosocial intervention for infertility." ..
  57. EFFECTIVE MEDIA STRATEGIES FOR DRUG ABUSE PREVENTION
    Philip Palmgreen; Fiscal Year: 2002
    ....
  58. Six Programs for the Future of Alcohol Safety
    Robert Voas; Fiscal Year: 2007
    ..Voas to become involved in a broader range of programs than if he otherwise were limited by taking on the full management of individual R01 projects. For this effort we are requesting 5 years of support for 75% of Dr. Voas' time. ..
  59. Decision Rules for Multiple Endpoints in Clinical Trials
    AJIT TAMHANE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. Transactivation of Fetal Hemoglobin
    KENNETH PETERSON; Fiscal Year: 2007
    ..This proposal will generate unique tools and new strategies to understand mechanisms of ?-globin gene regulation for treatment of SCD. ..
  61. HARLEM ADHERENCE WITH RETROVIRAL THERAPY STUDY
    Sharon Mannheimer; Fiscal Year: 2002
    ....
  62. EVALUATION OF EFFORTS TO REDUCE BORDER BINGE DRINKING
    Robert Voas; Fiscal Year: 2002
    ..El Paso/Juarez, a border town with a similar border-binge drinking problem will, serve as a comparison site. ..
  63. ENVIRONMENTAL PREVENTION OF COLLEGE ALCOHOL PROBLEMS
    Robert Voas; Fiscal Year: 2003
    ..abstract_text> ..
  64. Synchrotron-Based Infrared Microscope for Chemical Imaging of Disease
    Lisa Miller; Fiscal Year: 2007
    ..This instrument will be unique worldwide. [unreadable] [unreadable] [unreadable]..
  65. Molecular control of fetal G-globin gene expression
    KENNETH PETERSON; Fiscal Year: 2004
    ....
  66. GENETICS OF SEX DETERMINATION AND CELL DEATH IN PLANTS
    Stephen Dellaporta; Fiscal Year: 2004
    ..Hence, understanding the processes of tasselseed-mediated cell death, silkless-mediated cell protection and gibberellin-mediated cell arrest will be of fundamental importance in understanding many health-related processes. ..
  67. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2005
    ..abstract_text> ..
  68. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2005
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
  69. Machine learning analysis of tandem mass spectra
    William Stafford Noble; Fiscal Year: 2010
    ....
  70. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2005
    ....
  71. Lowering the drinking age: The New Zealand example
    Robert Voas; Fiscal Year: 2005
    ..abstract_text> ..