GDNF

Summary

Gene Symbol: GDNF
Description: glial cell derived neurotrophic factor
Alias: ATF, ATF1, ATF2, HFB1-GDNF, HSCR3, glial cell line-derived neurotrophic factor, astrocyte-derived trophic factor
Species: human

Top Publications

  1. ncbi Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis
    K Luukko
    Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 210:463-71. 1997
  2. ncbi Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions
    M Cik
    Department of Biochemical Pharmacology and the Department of Biotechnology and High Throughput Screening, Janssen Research Foundation, B 2340 Beerse, Belgium
    J Biol Chem 275:27505-12. 2000
  3. ncbi GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    L F Lin
    Synergen, Inc, Boulder, CO 80301
    Science 260:1130-2. 1993
  4. ncbi Defects in enteric innervation and kidney development in mice lacking GDNF
    J G Pichel
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda 20892, USA
    Nature 382:73-6. 1996
  5. ncbi Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
    P Akerud
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177 Stockholm, Sweden
    J Neurosci 21:8108-18. 2001
  6. ncbi Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan
    Mark W Barnett
    Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    J Cell Sci 115:4495-503. 2002
  7. ncbi The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands
    Gustavo Paratcha
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Retzius vag 8, A2 2, 17177, Stockholm, Sweden
    Cell 113:867-79. 2003
  8. ncbi Chromosome 5p aberrations are early events in lung cancer: implication of glial cell line-derived neurotrophic factor in disease progression
    Cathie Garnis
    British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, BC, Canada V5Z 3L1
    Oncogene 24:4806-12. 2005
  9. pmc The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding
    Vimal Parkash
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Biol Chem 283:35164-72. 2008
  10. pmc Functional RET G691S polymorphism in cutaneous malignant melanoma
    N Narita
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Oncogene 28:3058-68. 2009

Research Grants

  1. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2013
  2. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2010
  3. Reconstruction of the nigrostriatal pathway
    George M Smith; Fiscal Year: 2013
  4. Dual-hit hypothesis of aging-related DA dysfunction
    ANN CHARLOTTE ESTHER GRANHOLM; Fiscal Year: 2011
  5. APOPTOSIS IN SUBSTANTIA NIGRA
    Robert E Burke; Fiscal Year: 2011
  6. Michael J Zigmond; Fiscal Year: 2014
  7. LAURA RHEA WHITEAKER GAINEY; Fiscal Year: 2016
  8. Developing an Adenoviral Vector Platform for Selective Gene Delivery to Neurons
    Travis B Lewis; Fiscal Year: 2012
  9. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
  10. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009

Detail Information

Publications465 found, 100 shown here

  1. ncbi Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis
    K Luukko
    Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 210:463-71. 1997
    Glial cell line-derived neurotrophic factor (GDNF) is a recently identified survival factor for several populations of neurons in the central and peripheral nervous system that also regulates kidney development...
  2. ncbi Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions
    M Cik
    Department of Biochemical Pharmacology and the Department of Biotechnology and High Throughput Screening, Janssen Research Foundation, B 2340 Beerse, Belgium
    J Biol Chem 275:27505-12. 2000
    The members of the glial cell line-derived neurotrophic factor (GDNF) family signal via binding to the glycosyl phosphatidylinositol-anchored membrane proteins, the GDNF family receptors alpha (GFRalpha), and activation of cRET...
  3. ncbi GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    L F Lin
    Synergen, Inc, Boulder, CO 80301
    Science 260:1130-2. 1993
    ..Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-..
  4. ncbi Defects in enteric innervation and kidney development in mice lacking GDNF
    J G Pichel
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda 20892, USA
    Nature 382:73-6. 1996
    Glial-lial-cell-line-derived neurotrophic factor (GDNF) has been isolated as neurotrophic factor for midbrain dopaminergic neurons...
  5. ncbi Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
    P Akerud
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177 Stockholm, Sweden
    J Neurosci 21:8108-18. 2001
    ..deliver soluble molecules with neuroprotective activity, such as glial cell line-derived neurotrophic factor (GDNF)...
  6. ncbi Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan
    Mark W Barnett
    Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    J Cell Sci 115:4495-503. 2002
    Glial cell line-derived neurotrophic factor, GDNF, is vital to the development and maintenance of neural tissues; it promotes survival of sympathetic, parasympathetic and spinal motor neurons during development, protects midbrain ..
  7. ncbi The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands
    Gustavo Paratcha
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Retzius vag 8, A2 2, 17177, Stockholm, Sweden
    Cell 113:867-79. 2003
    ..Here, we show that the neural cell adhesion molecule NCAM can function as a signaling receptor for members of the GDNF ligand family...
  8. ncbi Chromosome 5p aberrations are early events in lung cancer: implication of glial cell line-derived neurotrophic factor in disease progression
    Cathie Garnis
    British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, BC, Canada V5Z 3L1
    Oncogene 24:4806-12. 2005
    ..The 0.34 Mbp region at 5p13.2 contains Glial Cell Line-Derived Neurotrophic Factor (GDNF), which is a ligand for the RET oncogene product and is normally expressed during lung development (but absent in ..
  9. pmc The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding
    Vimal Parkash
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Biol Chem 283:35164-72. 2008
    Glial cell line-derived neurotrophic factor (GDNF), a neuronal survival factor, binds its co-receptor GDNF family receptor alpha1 (GFR alpha 1) in a 2:2 ratio and signals through the receptor tyrosine kinase RET...
  10. pmc Functional RET G691S polymorphism in cutaneous malignant melanoma
    N Narita
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Oncogene 28:3058-68. 2009
    RET proto-oncogene encodes a receptor tyrosine kinase whose ligand is glial cell line-derived neurotrophic factor (GDNF), and its polymorphism at G691S juxtamembrane region (RETp) is a germline polymorphism...
  11. doi Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease
    Aleksandra Glavaski-Joksimovic
    Department of Pediatrics, Neurobiology Program, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    J Neurosci Res 88:2669-81. 2010
    ..The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF), the most potent neurotrophic factor for DA neurons, has been demonstrated in many experimental models of PD...
  12. doi Characterization of the intracellular localization, processing, and secretion of two glial cell line-derived neurotrophic factor splice isoforms
    Liina Lonka-Nevalaita
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    J Neurosci 30:11403-13. 2010
    ..study, we characterize the processing and secretion mechanisms of the glial cell line-derived neurotrophic factor (GDNF)...
  13. doi Age-associated decrease in serum glial cell line-derived neurotrophic factor levels in patients with major depressive disorder
    Ping Tao Tseng
    Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, corrected Kaohsiung, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 40:334-9. 2013
    ..This study examined serum levels of glial cell line-derived neurotrophic factor (GDNF), one of the neurotrophic factors, in patients with major depressive disorder (MDD) at different disease states.
  14. ncbi Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products
    L Grimm
    Department of Medical Genetics, University of Munich, Goethestrasse 29, 80336 Munich, Germany
    Hum Mol Genet 7:1873-86. 1998
    Glial cell line-derived neurotrophic factor (GDNF), a distant member of the TGF-beta superfamily, is a survival factor for various neurons, making it a potential therapeutic agent for neurodegenerative disorders...
  15. ncbi Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: polymorphism screening and association analysis
    K Lee
    Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chome, Itabashi ku, Tokyo 173 8605, Japan
    Psychiatry Res 104:11-7. 2001
    The glial cell line-derived neurotrophic factor (GDNF) is an important neurotrophic and potential differentiation factor for dopaminergic systems...
  16. ncbi 3' UTR (AGG)n repeat of glial cell line-derived neurotrophic factor (GDNF) gene polymorphism in schizophrenia
    Anna Michelato
    Genetic Unit, I R C C S San Giovanni di Dio, A Fa R, Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy
    Neurosci Lett 357:235-7. 2004
    ..The glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic and potential differentiation factor for dopaminergic systems...
  17. ncbi An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD
    Zahoor Syed
    Addenbrookes Hospital, Cambridge, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 144:375-8. 2007
    ..Glial derived neurotrophic factor (GDNF), nerve growth factor (NGF (beta subunit)), and neurotrophic factor 3 (NT3) are members of the neurotrophin family ..
  18. pmc The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding
    Ivan Alfano
    School of Biological Sciences, Royal Holloway University of London, Egham Hill, Egham, Surrey TW20 OEX, UK
    Biochem J 404:131-40. 2007
    b>GDNF (glial cell-line-derived neurotrophic factor), and the closely related cytokines artemin and neurturin, bind strongly to heparin...
  19. ncbi Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia
    H J Williams
    Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Schizophr Res 97:271-6. 2007
    The glial cell line-derived neurotrophic factor (GDNF) gene is located within a region of chromosome 5 (5p14.1-q13.3) that has been highlighted as a potential schizophrenia susceptibility locus by a number of genome scans...
  20. doi Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population
    Tomoko Yoshimura
    Division of Clinical Science and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Aichi, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1268-72. 2011
    ..Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder...
  21. doi Association study between plasma GDNF and cognitive function in late-onset depression
    Xiaoquan Wang
    Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, PR China
    J Affect Disord 132:418-21. 2011
    ..The glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor-β-family, which plays a role in the development and ..
  22. ncbi The relationship between overexpression of glial cell-derived neurotrophic factor and its RET receptor with progression and prognosis of human pancreatic cancer
    Q Zeng
    Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang Province, China
    J Int Med Res 36:656-64. 2008
    We used immunohistochemical staining to assess protein over-expression of glial cell-derived neurotrophic factor (GDNF) and its RET receptor tyrosine kinase in patients with pancreatic cancer and benign pancreatic neoplasm, and assessed ..
  23. ncbi Electrical activity regulates AChR gene expression via JNK, PKCzeta and Sp1 in skeletal chick muscle
    N Altiok
    Kadir Has University Medical Faculty, Department of Pharmacology, Istanbul, Turkey
    FEBS Lett 487:333-8. 2001
    ..increase of the threonine phosphorylation of protein kinase Czeta (PKCzeta) and activator of transcription factor (ATF2) and a decrease of the phosphorylation of Sp1...
  24. pmc Combinatorial generation of variable fusion proteins in the Ewing family of tumours
    J Zucman
    , INSERM CJF 9201, Paris, France
    EMBO J 12:4481-7. 1993
    ..of band 22q12 to chromosome 11 and 12 result in the fusion of EWS with the transcription factors FLI-1 and ATF1, respectively...
  25. ncbi Enhancement of glial cell line-derived neurotrophic factor expression in rat adrenal glands by toluene exposure
    T Gotohda
    Department of Legal Medicine, Tokushima University School of Medicine, Kuramoto, Japan
    Horm Metab Res 32:301-5. 2000
    ..While glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-beta superfamily, has recently been shown to be expressed in rat ..
  26. pmc Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains
    J Kim
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Nucleic Acids Res 23:2531-7. 1995
    ..First, analysis of GCN4-ATF1 hybrid proteins indicates that a short surface spanning the basic and fork regions of the bZIP domain is the major ..
  27. ncbi Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2
    Keith E Fox
    Research Service, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 281:40341-53. 2006
    ..In this report we used small interfering RNA to deplete CREB and the closely related factor ATF1 to explore the ability of the master adipogenic regulators to promote adipogenesis in the absence of CREB and probe ..
  28. ncbi Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor
    Harry A Otun
    School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Soc Gynecol Investig 12:185-90. 2005
    We have recently identified a novel putative spliced variant of the activating transcription factor 2 (ATF2) in the human myometrium during pregnancy and labor...
  29. ncbi Effects of polychlorinated biphenyls (PCBs) on expression of neurotrophic factors in C6 glial cells in culture
    Gordon H Gurley
    Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008 5410, United States
    Neurotoxicology 28:1264-71. 2007
    ..1% dimethyl sulfoxide (DMSO=vehicle), or normal culture medium. Glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) protein were measured by enzyme-linked immunosorbant assay...
  30. doi Enhancement of regeneration with glia cell line-derived neurotrophic factor-transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury
    Fu Chou Cheng
    Stem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
    J Neurosurg 112:868-79. 2010
    ..The present study evaluates whether the transplantation of glia cell line-derived neurotrophic factor (GDNF)-modified human AFMSCs may enhance regeneration of sciatic nerve after a crush injury.
  31. pmc Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival
    Neil A Shneider
    Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032, USA
    Neural Dev 4:42. 2009
    ..Recently, it was reported that early embryonic gamma-MN precursors are dependent on GDNF. Using this knowledge we characterized genetic strategies to label developing gamma-MNs based on GDNF receptor ..
  32. ncbi Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation
    K Luukko
    Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 213:207-19. 1998
    Neurturin (NTN) is a recently characterized member of the glial cell line-derived neurotrophic factor (GDNF)-family which, like GDNF, can promote the survival of certain populations of neuronal cells in peripheral and central nervous ..
  33. ncbi Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse
    J P Golden
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Exp Neurol 158:504-28. 1999
    The GDNF family of neurotrophic factors currently has four members: neurturin (NRTN), glial cell line-derived neurotrophic factor (GDNF), persephin, and artemin...
  34. ncbi Developmental changes in neurite outgrowth responses of dorsal root and sympathetic ganglia to GDNF, neurturin, and artemin
    H Yan
    Department of Anatomy and Cell Biology, University of Melbourne, Vic, Australia
    Dev Dyn 227:395-401. 2003
    The ability of glial cell line-derived neurotrophic factor (GDNF), neurturin, and artemin to induce neurite outgrowth from dorsal root, superior cervical, and lumbar sympathetic ganglia from mice at a variety of development stages between ..
  35. ncbi Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells
    L You
    Department of Ophthalmology, University of Heidelberg Medical School, Germany
    Invest Ophthalmol Vis Sci 42:2496-504. 2001
    To identify signal-transduction pathways induced by glial cell-derived neurotrophic factor (GDNF) in corneal epithelial cells and to characterize its effect on cell migration.
  36. ncbi [The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats]
    W Zhou
    Ningbo Institute of Microcirculation and Henbane, Ningbo Drug Addiction Research and Treatment Center, Ningbo 315010, China
    Zhonghua Yi Xue Za Zhi 80:135-9. 2000
    To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of ..
  37. ncbi Effects of dopamine agonists bromocriptine, pergolide, cabergoline, and SKF-38393 on GDNF, NGF, and BDNF synthesis in cultured mouse astrocytes
    Kiyoe Ohta
    Clinical Research Center, Utano National Hospital, Ukyo ku, Kyoto 616 8255, Japan
    Life Sci 73:617-26. 2003
    ..growth factor, NGF; brain-derived neurotrophic factor, BDNF; and glial cell line-derived neurotrophic factor, GDNF) in cultured mouse astrocytes, and clarified the role of dopamine D1 and D2 receptors in these effects...
  38. doi RET/GDNF signalling in vagal neural crest-derived neurons of the chick embryo cloaca
    Anne Marie O' Donnell
    Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    Pediatr Surg Int 24:1211-4. 2008
    The growth factor, 'Glial cell line-Derived Neurotrophic Factor' (GDNF), is involved in the development of enteric ganglia, using the tyrosine kinase receptor 'REarranged during Transfection' (RET) to stimulate the proliferation and ..
  39. pmc Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters
    Kevin J Verstrepen
    Centre for Malting and Brewing Science, Department of Food and Microbial Technology, Katholieke Universiteit Leuven, B 3001 Louvain Heverlee, Belgium
    Appl Environ Microbiol 69:5228-37. 2003
    ..Analysis of the fermentation products confirmed that the expression levels of ATF1 and ATF2 greatly affect the production of ethyl acetate and isoamyl acetate...
  40. ncbi Permanent rescue of lesioned neonatal motoneurons and enhanced axonal regeneration by adenovirus-mediated expression of glial cell-line-derived neurotrophic factor
    B J Baumgartner
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 54:766-77. 1998
    ..We tested whether an adenoviral vector carrying the gene for glial cell-line-derived neurotrophic factor (Adv.RSV-GDNF) would prevent neonatal motoneuron death after facial nerve transection or crush...
  41. ncbi EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Chromosomes Cancer 46:1051-60. 2007
    ..is not well defined, with only six cases with specific gene fusions reported to date, consisting of either FUS-ATF1 or EWSR1-ATF1...
  42. pmc Post-treatment effects of local GDNF administration to the inner ears of deafened guinea pigs
    Anette Fransson
    Center for Hearing and Communication Research and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurotrauma 27:1745-51. 2010
    ..Following deafferentation, glial cell-derived neurotrophic factor (GDNF) is known to affect spiral ganglion neuron survival...
  43. ncbi Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development
    Jennifer Whitehead
    Department of Pathology Neuropathology, Northwestern University, Chicago, IL 60611, USA
    Mech Dev 122:27-41. 2005
    Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for motor neurons...
  44. ncbi Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST?
    Marie Noelle Delyfer
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, Institut National de la Santé et de la Recherche Médicale Inserm U592, Universite Pierre et Marie Curie, Paris, France
    Mol Vis 11:677-87. 2005
    We previously demonstrated that exogenous glial cell line-derived neurotrophic factor (GDNF) induces histological and functional protection of photoreceptors in the retinal degeneration (rd1) mouse model...
  45. ncbi Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Int J Cancer 99:560-7. 2002
    ..The cytogenetic hallmark is the translocation t(12;22)(q13;q12) resulting in a chimeric EWS/ATF1 gene in which the 3'-terminal part of EWS at 22q is replaced by the 3'-terminal part of ATF1 at 12q...
  46. ncbi GDNF and IGF-I trophic factors delay hereditary Purkinje cell degeneration and the progression of gait ataxia
    Daniel L Tolbert
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Exp Neurol 183:205-19. 2003
    Neurotrophic factors GDNF and/or IGF-I were chronically infused into shaker mutant rats to rescue cerebellar Purkinje neurons from adult-onset heredodegeneration...
  47. pmc Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving
    Mikko Airavaara
    Intramural Research Program and National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Addict Biol 16:261-72. 2011
    Glial cell line-derived neurotrophic factor (GDNF) activity in ventral tegmental area (VTA) mediates the time-dependent increases in cue-induced cocaine-seeking after withdrawal (incubation of cocaine craving)...
  48. ncbi GDNF pre-treatment aggravates neuronal cell loss in oxygen-glucose deprived hippocampal slice cultures: a possible effect of glutamate transporter up-regulation
    C Bonde
    Anatomy and Neurobiology, SDU Odense University, Winsløwparken 21, DK 5000 Odense C, Denmark
    Neurochem Int 43:381-8. 2003
    ..effects on dopaminergic neurons and spinal motoneurons, glial cell line-derived neurotrophic factor (GDNF) has potent neuroprotective effects in cerebral ischemia...
  49. ncbi Grafting of glial cell line-derived neurotrophic factor secreting cells for hypoxic-ischemic encephalopathy in neonatal rats
    Shinji Katsuragi
    Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake cho, Miyazaki, Japan
    Am J Obstet Gynecol 192:1137-45. 2005
    ..The aim of this study was to examine the neuroprotective effect of glial cell line-derived neurotrophic factor with the use of this delivery system...
  50. ncbi EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma
    Sabrina Rossi
    Department of Pathology, Regional Hospital, Treviso, Italy
    Clin Cancer Res 13:7322-8. 2007
    ..Either FUS-ATF1 or EWSR1-ATF1 have been detected in the few cases published, pointing to the interchangeable role of FUS and EWSR1 ..
  51. pmc Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys
    Louisa C Johnston
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103, USA
    Hum Gene Ther 20:497-510. 2009
    ..Safety and efficacy of an adeno-associated virus (AAV2) encoding human glial cell-derived neurotrophic factor (GDNF) was investigated in aged nonhuman primates...
  52. doi Delayed administration of glial cell line-derived neurotrophic factor (GDNF) protects retinal ganglion cells in a pig model of acute retinal ischemia
    Maria Voss Kyhn
    Department of Ophthalmology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Exp Eye Res 89:1012-20. 2009
    This study investigates whether intravitreal administration of glial cell line-derived neurotrophic factor (GDNF) enhances survival of NeuN positive retinal cells in a porcine model of retinal ischemia...
  53. doi Image-guided convection-enhanced delivery of GDNF protein into monkey putamen
    Francisco Gimenez
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103 0555, USA
    Neuroimage 54:S189-95. 2011
    ..can be used for MRI-monitored infusions into the non-human primate (NHP) putamen to predict the distribution of GDNF protein after convection-enhanced delivery (CED)...
  54. pmc Directing dopaminergic fiber growth along a preformed molecular pathway from embryonic ventral mesencephalon transplants in the rat brain
    Y Jin
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci Res 89:619-27. 2011
    ..pathways were created by expressing green fluorescent protein (GFP), glial cell line-derived neurotrophic factor (GDNF), or a combination of GDNF/GDNF receptor α1 (GFRα1) along the corpus callosum...
  55. ncbi Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    Dipa Natarajan
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:5151-60. 2002
    ..evidence that activation of the receptor tyrosine kinase RET by glial cell line-derived neurotrophic factor (GDNF) is required for the directional migration of ENS progenitors towards and within the gut wall...
  56. ncbi Isolation and characterization of the ATF2 gene encoding alcohol acetyltransferase II in the bottom fermenting yeast Saccharomyces pastorianus
    H Yoshimoto
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanagawa, Japan
    Yeast 15:409-17. 1999
    ..pastorianus ATF2 gene was cloned by colony hybridization using the S. cerevisiae ATF2 gene as a probe. When an atf1 null mutant strain was transformed with a multi-copy plasmid carrying the S...
  57. ncbi GDNF improves cerebellar Purkinje neuron function in aged F344 rats
    P C Bickford
    Veterans Administration Medical Center, Tampa, Florida 33612, USA
    Microsc Res Tech 54:309-16. 2001
    ..Glial cell line-derived neurotrophic factor (GDNF) has been reported to prevent the degeneration of noradrenergic neurons following neurotoxic lesions...
  58. ncbi The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair
    Jun Hayakawa
    Department of Cancer Gene Therapy, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 278:20582-92. 2003
    The activating transcription factor 2 (ATF2) is a member of the ATF/cAMP-response element-binding protein family of basic-leucine zipper proteins involved in cellular stress response...
  59. doi Neuronal differentiation elicited by glial cell line-derived neurotrophic factor and ciliary neurotrophic factor in adrenal chromaffin cell line tsAM5D immortalized with temperature-sensitive SV40 T-antigen
    Tomiyasu Murata
    Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan
    J Neurosci Res 86:1694-710. 2008
    ..we first examined the responsiveness of the cells to ligands of the glial cell line-derived neurotrophic factor (GDNF) family...
  60. pmc Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor
    Sebastien Carnicella
    The Gallo Research Center, University of California, San Francisco, Emeryville, California, USA
    Biol Psychiatry 66:146-53. 2009
    ..Cabergoline is an ergotamine derivative that increases the expression of glial cell line-derived neurotrophic factor (GDNF) in vitro...
  61. doi Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats
    Jingwei Shang
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Neurosci Res 88:2197-206. 2010
    Glial cell line-derived neurotrophic factor (GDNF) and hepatocyte growth factor (HGF) are strong neurotrophic factors, which function as antiapoptotic factors...
  62. ncbi [The repair of acute spinal cord injury in rats by olfactory ensheathing cells graft modified by glia cell line-derived neurotrophic factor gene in combination with the injection of monoclonal antibody IN-1]
    Hui Bo Yan
    Department of Spinal Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China
    Zhonghua Wai Ke Za Zhi 47:1817-20. 2009
    To research the repair effect of transplantation of glial cell line-derived neurotrophic factor (GDNF) modified olfactory ensheathing cells (OECs) combination with injecting axonal growth inhibiting protein antibody (IN-1) in vivo.
  63. doi Glial cell line-derived neurotrophic factor is a key neurotrophin in the postnatal enteric nervous system
    D M Rodrigues
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Neurogastroenterol Motil 23:e44-56. 2011
    ..However, little is known about factors in the postnatal intestine that influence these processes...
  64. ncbi Expression of glial cell line-derived neurotrophic factor in the brain and cerebrospinal fluid of the developing rat
    T Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan
    Int J Dev Neurosci 17:681-91. 1999
    Expression of GDNF in developing rat brain from PND 1 to 14 and on PND 21 was examined immunocytochemically...
  65. ncbi Ultrastructural study of anterograde transport of glial cell line-derived neurotrophic factor from dorsal root ganglion neurons of rats towards the nerve terminal
    K Ohta
    Department of Anatomy and Histology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Fukuoka, Japan
    Cells Tissues Organs 169:410-21. 2001
    The glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic substance in the central and peripheral nervous systems...
  66. ncbi Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells
    K Hisaoka
    Department of Psychiatry and Neuroscience, Institute of Clinical Research, National Kure Medical Center, Kure, Japan
    J Neurochem 79:25-34. 2001
    ..However, the effect of antidepressants on modulation of glial cell line-derived neurotrophic factor (GDNF), which has potent and widespread effects, remains unknown...
  67. ncbi Local administration of glial cell line-derived neurotrophic factor improves behavioral and histological deficit of neonatal Erb's palsy in rats
    Hidenobu Ochiai
    Department of Neurosurgery, Miyazaki Medical College, Miyazaki, Japan
    Neurosurgery 53:973-7; discussion 977-8. 2003
    We sought to evaluate from a behavioral and histological viewpoint the effect of local administration of glial cell line-derived neurotrophic factor (GDNF) on neonatal preganglionic Erb's palsy in rats.
  68. pmc Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons
    Giuseppe Battaglia
    Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy
    PLoS ONE 4:e6591. 2009
    ..25-3 mg/kg, i.p.) increased glial cell line-derived neurotrophic factor (GDNF) mRNA and protein levels in the mouse brain, as assessed by in situ hybridization, real-time PCR, immunoblotting, ..
  69. ncbi Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system
    C A Nosrat
    Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    Cell Tissue Res 286:191-207. 1996
    Glial-cell-line-derived neurotrophic factor (GDNF) is a distant member of the transforming growth factor-beta family and has potent neurotrophic effects on several classes of neurons including dopamine neurons and motoneurons...
  70. ncbi Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells
    R Firestein
    Center for Gerontology, Allegheny University of the Health Sciences and the Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:5892-902. 1998
    Activating transcription factor 2 (ATF2) is regulated by phosphorylation via the Jun N-terminal kinase, and its binding activity is markedly induced at late stages of T and B lymphocyte activation (Feuerstein, N., Firestein, R., Aiyer, N...
  71. pmc Distribution of glial cell line-derived neurotrophic factor receptor alpha-1 in the brain of adult zebrafish
    Carla Lucini
    Department of Biological Structures, Functions and Technology, University of Naples Federico II, Naples, Italy
    J Anat 217:174-85. 2010
    Glial cell line-derived neurotrophic factor (GDNF) is a potent trophic factor for several types of neurons in the central and peripheral nervous systems...
  72. ncbi Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system
    Carl Rosenblad
    NsGene A S, Ballerup, Denmark
    Eur J Neurosci 17:260-70. 2003
    ..To investigate the effect of long-term glial cell line-derived neurotrophic factor (GDNF) overexpression on intact nigrostriatal dopamine neurons, we injected a recombinant lentiviral vector encoding GDNF,..
  73. pmc Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier
    Ailing Fu
    Department of Medicine, UCLA, Los Angeles, CA 90024, USA
    Brain Res 1352:208-13. 2010
    Glial-derived neurotrophic factor (GDNF) is a trophic factor for the nigra-striatal tract in experimental Parkinson's disease (PD)...
  74. ncbi Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF)
    M Saarma
    Program for Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Microsc Res Tech 45:292-302. 1999
    Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease...
  75. ncbi Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats
    Shinji Katsuragi
    Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake cho, Miyazaki, Japan
    Am J Obstet Gynecol 192:1028-37. 2005
    ..We examined the effect of glial cell line-derived neurotrophic factors on long-term learning and memory impairment and morphological changes up to 18 weeks after hypoxic-ischemic stress in neonatal rats...
  76. ncbi GDNF-induced neurite formation was stimulated by protein kinase inhibitors and suppressed by Ras inhibitors
    T Hiwasa
    Department of Biochemistry, School of Medicine, Chiba University, Japan
    Neurosci Lett 238:115-8. 1997
    The effects of various inhibitors on the glial cell line-derived neurotrophic factor (GDNF)-induced neurite formation in TGW human neuroblastoma cells were investigated...
  77. ncbi High-level expression of receptor tyrosine kinase Ret and responsiveness to Ret-activating ligands in pheochromocytoma cell lines from neurofibromatosis knockout mice
    James F Powers
    Institute of Genetics, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Mol Cell Neurosci 20:382-9. 2002
    ..Mouse pheochromocytoma (MPC) cells respond to the Ret-activating ligand GDNF by exhibiting Ret phosphorylation, neurite outgrowth, decreased proliferation, and altered expression of ..
  78. ncbi Bystander effects: intercellular transmission of radiation damage signals
    J B Little
    Harvard School of Public Health, Laboratory of Radiobiology, 665 Huntington Avenue, Boston, MA 02115, USA
    Radiat Prot Dosimetry 99:159-62. 2002
    ..mobility shift assays; a 2-4-fold increase in the phosphorylation levels of JNK, ERK1/2, p90RSK, Elk-1 and ATF2 was observed. These changes were detected by 15 min after irradiation and persisted for at least 1 h...
  79. ncbi Suppression of GDNF production by MPSS treatment following spinal cord injury in the rat
    Shojiro Nakashima
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, 466 8550, Japan
    Neuroreport 15:2337-40. 2004
    ..On the other hand, glial cell line-derived neurotrophic factor (GDNF) acts as a potent survival factor for several neuronal populations, providing a therapeutic promise for ..
  80. pmc Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS
    Claire E McCoy
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 402:491-501. 2007
    ..its related isoform MSK2, phosphorylate the transcription factors CREB (cAMP-response-element-binding protein) and ATF1 (activating transcription factor 1), and the chromatin proteins histone H3 and HMGN1 (high-mobility-group ..
  81. ncbi Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration
    Carmen Cabanes
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, E 03550 San Juan de Alicante, Alicante, Spain
    Neurobiol Dis 26:408-18. 2007
    ..These effects can be explained by the increased levels of glial cell line derived neurotrophic factor (GDNF) around host motoneurons produced by the grafted cells...
  82. doi Olfactory ensheathing cells represent an optimal substrate for hippocampal neurons: an in vitro study
    Rosalia Pellitteri
    Institute of Neurological Sciences, National Research Council, Section of Catania, via P Gaifami 18, 95126 Catania, Italy
    Int J Dev Neurosci 27:453-8. 2009
    ..Some hippocampal cultures were added with growth factors, as bFGF, NGF and GDNF. Furthermore, conditioned medium from OECs cultures was used to feed some hippocampal neurons coverslips...
  83. pmc Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation
    Hung Ming Wu
    College of Medicine, Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan
    Neuropsychopharmacology 34:2344-57. 2009
    ..neurotrophic effects through the increased production of glial cell line-derived neurotrophic factor (GDNF)...
  84. pmc Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector
    Fredric P Manfredsson
    Department of Neuroscience, Powell Gene Therapy Center, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32611, USA
    Mol Ther 17:1857-67. 2009
    Glial cell line-derived neurotrophic factor (GDNF) gene transfer is being developed as a treatment for Parkinson's disease (PD)...
  85. pmc Role of BDNF and GDNF in drug reward and relapse: a review
    Udi E Ghitza
    Center for the Clinical Trials Network, NIDA, NIH, Bethesda, MD, USA
    Neurosci Biobehav Rev 35:157-71. 2010
    Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are neurotrophic factors that are critical for the growth, survival, and differentiation of developing neurons...
  86. doi Expression of GDNF receptors GFRalpha1 and RET is preserved in substantia nigra pars compacta of aging Asian Indians
    Phalguni Anand Alladi
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, Karnataka, India
    J Chem Neuroanat 40:43-52. 2010
    Glial derived neurotrophic factor (GDNF) protects dopaminergic nigral neurons and may prevent the progression of age-related motor deficits and Parkinson's disease...
  87. doi Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion
    Jingwei Shang
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikatacho, Okayama, Japan
    J Neurosci Res 89:86-95. 2011
    Hepatocyte growth factor (HGF) and glial cell line-derived neurotrophic factor (GDNF) are strong neurotrophic factors. However, their potentials in neurogenesis, angiogenesis, synaptogenesis, and antifibrosis have not been compared...
  88. doi Enhanced GDNF expression in dopaminergic cells of monkeys grafted with carotid body cell aggregates
    M R Luquin
    Laboratory of Regenerative Therapy, Centre for Applied Medical Research CIMA, University of Navarra, 31008 Pamplona, Navarra, Spain
    Brain Res 1375:120-7. 2011
    ..in UL-grafted animals, and the number of dopaminergic cells expressing glial cell line-derived neurotrophic factor (GDNF) in all groups. After 1 year, animals showed a significant recovery of the parkinsonism (San Sebastian et al...
  89. doi Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells
    Ping Zhao
    Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, People s Republic of China
    Hum Reprod 26:695-702. 2011
    ..the paracrine roles of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in promoting oocyte maturation, we investigated the expression of these ligands in human granulosa cells and their ..
  90. pmc Combining glial cell line-derived neurotrophic factor gene delivery (AdGDNF) with L-arginine decreases contusion size but not behavioral deficits after traumatic brain injury
    M L Degeorge
    DePaul University, Department of Biological Sciences, Chicago, IL 60614, USA
    Brain Res 1403:45-56. 2011
    ..An adenoviral vector harboring human GDNF was injected unilaterally into FL-SMC of the rat immediately following a unilateral CCI over the FL-SMC...
  91. ncbi Inhibition of the p38 mitogen-activated protein kinase (MAPK) pathway attenuates cerebral vasospasm following experimental subarachnoid hemorrhage in rabbits
    Xing Zhang
    Department of Neurosurgery, Jinling Hospital 305 East Zhongshan Road, Nanjing 210002, P R China
    Ann Clin Lab Sci 41:244-50. 2011
    ..Immunoblotting assays showed enhanced phosphorylation of p38 MAPK and ATF2 and increased caspase-3 cleavage following SAH, which were, however, markedly suppressed by SB203580...
  92. doi FGF2 deficit during development leads to specific neuronal cell loss in the enteric nervous system
    Cornelia Irene Hagl
    Clinic of Pediatric Surgery, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68163, Mannheim, Germany
    Histochem Cell Biol 139:47-57. 2013
    ..Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor-2 (FGF2) play an important role in the differentiation and function of the ENS...
  93. doi Kit ligand and glial-derived neurotrophic factor as alternative supplements for activation and development of ovine preantral follicles in vitro
    F Esmaielzadeh
    Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
    Mol Reprod Dev 80:35-47. 2013
    ..This study investigated the effect of glial-derived neurotropic factor (GDNF) and kit ligand (KL) on the in vitro development of ovine preantral follicles...
  94. ncbi [Effects of Danshen injection on glial cell line-derived neurotrophic factor mRNA of acute spinal cord injury rats and its mechanisms]
    Li Wei
    Orthopedic Institute of Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
    Zhongguo Zhong Xi Yi Jie He Za Zhi 33:933-7. 2013
    To observe effects of Danshen Injection (DSI) on glial cell line-derived neurotrophic factor (GDNF) in the gray matter of acute spinal cord injury (SCI) rats and to discuss its mechanisms.
  95. pmc Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    J Cell Sci 127:2920-33. 2014
    ..as the transcription factor responsible for p27-regulated MnSOD expression, which was further mediated by ERK- and ATF1-dependent transactivation of the cAMP response element (CRE) within the Stat3 promoter...
  96. pmc Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism
    Katrina L Paumier
    Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
    Neuropsychopharmacology 40:874-83. 2015
    ..trophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) may be key mediators of the therapeutic response to antidepressants...
  97. doi Effects of Forskolin on Trefoil factor 1 expression in cultured ventral mesencephalic dopaminergic neurons
    P Jensen
    Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Winsløwparken 21, DK 5000 Odense C, Denmark Department of Neurosurgery, Neurocenter and Regenerative Neuroscience Cluster, University of Berne, CH 3010 Berne, Switzerland Electronic address
    Neuroscience 310:699-708. 2015
    ..for 5, 7 or 10 days in the absence (controls) or presence of either glial cell line-derived neurotrophic factor (GDNF), Forskolin or the combination...
  98. pmc Characterization of dendritic morphology and neurotransmitter phenotype of thoracic descending propriospinal neurons after complete spinal cord transection and GDNF treatment
    Lingxiao Deng
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202 Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Goodman and Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, Indiana 46202
    Exp Neurol 277:103-14. 2016
    ..greater regenerative capacity, which can be further enhanced by glial cell line-derived neurotrophic factor (GDNF)...
  99. doi Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase D1 in human bronchial epithelial cells
    Jun Bon Koo
    Biomedical Research Institute and Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Korea
    J Toxicol Sci 41:77-89. 2016
    ..Moreover, PLD1 siRNA transfection decreased CSE-induced ATF2 phosphorylation and IL-6 expression...
  100. doi Bioactive Components in Human Milk Along the First Month of Life: Effects of Iodine Supplementation during Pregnancy
    Ines Velasco
    Pediatrics, Obstetrics and Gynecology Unit, Riotinto Hospital, Andalusian Health Service, Huelva, Spain
    Ann Nutr Metab 68:130-6. 2016
    ..of neonatal intestine (brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), glial fibrillary acidic protein (GFAP), fibroblast growth factor 21 (FGF21), lysophosphatidic acid (LPA) and ..
  101. doi Blockade of glial-derived neurotrophic factor in laryngeal muscles promotes appropriate reinnervation
    Ignacio Hernández-Morato
    Department of Anatomy and Cell Biology, New York Medical College, Valhalla, New York
    Laryngoscope 126:E337-42. 2016
    ..Glial-derived neurotrophic factor (GDNF) is elevated in rat laryngeal muscles during RLN reinnervation...

Research Grants68

  1. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2013
    ..in motor impairments, has been associated with a reduction of glial cell line-derived neurotrophic factor (GDNF) in the substantia nigra, increased oxidative stress, and an increase in the indirect pathway of the basal ganglia ..
  2. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2010
    ..in motor impairments, has been associated with a reduction of glial cell line-derived neurotrophic factor (GDNF) in the substantia nigra, increased oxidative stress, and an increase in the indirect pathway of the basal ganglia ..
  3. Reconstruction of the nigrostriatal pathway
    George M Smith; Fiscal Year: 2013
    ..Preliminary data is presented showing that a combination of glial cell line-derived neurotrophic factor (GDNF) and its alpha-1co-receptor (GFR-11) or netrin-1 support long distance axon growth from dopaminergic transplants in ..
  4. Dual-hit hypothesis of aging-related DA dysfunction
    ANN CHARLOTTE ESTHER GRANHOLM; Fiscal Year: 2011
    ..Project 0003 will integrate the different treatments (GDNF/BDNF partial deletion, LPS treatment, and methamphetamine) from the perspective of neuroinflammation, and Project ..
  5. APOPTOSIS IN SUBSTANTIA NIGRA
    Robert E Burke; Fiscal Year: 2011
    ..Our specific goals in this proposal are to define the role played by the neurotrophic factors GDNF and BDNF in maintaining the viability of dopamine neurons of the substantia nigra during development and in ..
  6. Michael J Zigmond; Fiscal Year: 2014
    ..in exercise-induced protection members of four distinct NTF families known to protect DA neurons will be examined: GDNF, BDNF, MANF, and VEGF...
  7. LAURA RHEA WHITEAKER GAINEY; Fiscal Year: 2016
    ..Finally, the functional effects of up-regulated Nurr1 signaling by infusion of its downstream mediator GDNF into the VTA of mice will be tested...
  8. Developing an Adenoviral Vector Platform for Selective Gene Delivery to Neurons
    Travis B Lewis; Fiscal Year: 2012
    ..order to assess the efficacy of this vector as a platform for therapy, the reporter transgene will be replaced with GDNF. We will then validate the vector's ability to deliver this therapeutic payload to a high proportion of the SN ..
  9. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..is most commonly caused by mutations that reduce signaling through the glial cell line-derived neurotrophic factor (GDNF) or endothelin-3 (EDN3) signaling pathways ADDIN EN...
  10. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  11. John D Elsworth; Fiscal Year: 2014
    ..dependency and specificity of spine synapse changes in the motor-asymptomatic primate MPTP model, examining GDNF gene transfer and pharmacological strategies for their restoration, using biochemical, electron microscopic and ..
  12. The Efficacy of the Neurotrophic Factor CDNF in Treating Parkinsonian Symptoms
    Amanda M Dettmer; Fiscal Year: 2011
    ..and concern about clinical issues have been significant drawbacks for further clinical development of NTFs such as GDNF and BDNF...
  13. Senlin Li; Fiscal Year: 2016
    ..Glial cell line-derived neurotrophic factor (GDNF) has been the most potent trophic molecule tested so far and in numerous studies has clearly demonstrated a ..
  14. The Neurotrophic Factor GDNF and Alcohol Addiction
    Dorit Ron; Fiscal Year: 2013
    ..goal is to test the hypothesis that growth factors such as the glial cell line-derived neurotrophic factor (GDNF) counteract the adverse actions of alcohol and thus prevent or delay the development of alcohol addiction...
  15. Mitochondrial protection of a GDNF propeptide
    Luke H Bradley; Fiscal Year: 2012
    ..Examination of the glial cell line-derived neurotrophic factor (GDNF) prosequence predicts internal dibasic endopeptidase sites that would yield a smaller, amidated eleven amino acid ..
  16. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The neurorestorative and neuroprotective trophic actions of GDNF on midbrain dopamine (DA) neurons provide a promising but controversial therapeutic approach for the treatment of Parkinson's ..
  17. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..exogenous application of brain derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) delivered from biodegradable microspheres was temporally correlated with recovering visual function (pupil light ..
  18. Michael F Salvatore; Fiscal Year: 2015
    ..rate-limiting enzyme in DA biosynthesis, is regulated by phosphorylation, and is influenced by the growth factor GDNF. Notably, GDNF increases locomotor activity, nigral DA tissue content, and nigral TH phosphorylation at ser31...
  19. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..Indeed, Insulin-like growth factor-1 (IGF-1), glial derived neurotrophic factor (GDNF), and vascular endothelial growth factor (VEGF) delivered at disease onset in ALS rodent models have demonstrated ..
  20. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..We study a subtype of nociceptor that depends on glial cell line-derive neurotrophic factor (GDNF) family ligands (GFLs) for postnatal survival...
  21. Quantitative Analysis of RET Receptor Activation and Signaling
    Adrian Whitty; Fiscal Year: 2013
    ..RET is activated by a family of four neuronal growth factors, GDNF, Neurturin, Artemin (ART) and persephin, in conjunction one of four membrane-bound co-receptors known as GFR1-4...
  22. Survival and growth-promotion mechanisms of the GDNF family ligands (GFLs)
    BRIAN ANTHONY PIERCHALA; Fiscal Year: 2012
    The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) are four homologous neuronal growth factors that regulate the development of the nervous system and the maintenance of the adult nervous system...
  23. Neuroprotective Gene Therapy in the Brain of Senile Rats
    Rodolfo G Goya; Fiscal Year: 2010
    ..factor gene therapy in the brain of aging rats, using the genes for glial cell line-derived neurotrophic factor (GDNF) and insulin-like growth factor I (IGF-I), two neuroprotective molecules of growing clinical interest...
  24. Gdnf and endothelin-3 regulate colorectal enteric nervous system development
    Allan M Goldstein; Fiscal Year: 2013
    ..abstract_text> ..
  25. David M Yurek; Fiscal Year: 2015
    ..feasibility of delivering a gene encoding for the neurotrophic factor glial cell line-derived neurotrophic factor (GDNF) to brain cells as a means to protect the brain against neuronal degeneration that occurs in an animal model of PD...
  26. GDNF and Ret are critical for glomerular development, maintenance, and protection
    CYNTHIA TSUI; Fiscal Year: 2013
    ..Glial cell line-derived neurotrophic factor (GDNF) and its receptor tyrosine kinase, Ret, are upregulated selectively by podocytes in animal models of glomerular ..
  27. Characterization and Plasticity of Visceral Nociceptors
    Brian M Davis; Fiscal Year: 2012
    ..We also found that all members of the GDNF family of growth factors could, like NGF, sensitize primary sensory neurons and that these growth factors produced ..
  28. Function of Ret-GFL signaling in sensory neurons
    Judith Golden; Fiscal Year: 2009
    ..down-regulates TrkA expression and expresses Ret, the receptor for the neurotrophic factors belonging to the GDNF family...
  29. Pankaj J Pasricha; Fiscal Year: 2016
    ..pathway responsible for the normal development of the enteric nervous system, glial derived neurotrophic factor or GDNF, and its cognate receptor, RET...
  30. Analysis of Ret signaling in Drosophila enteric nervous system development.
    Thomas Kidd; Fiscal Year: 2011
    ..kinase, RET, to detect and migrate towards a chemoattractive ligand, Glial Cell Line-Derived Neurotrophic Factor (GDNF)...
  31. TROPHIC MANIPULATIONS OF THE OCULOMOTOR SYSTEM
    Christopher S von Bartheld; Fiscal Year: 2010
    ..on trophic factors with established effects in the oculomotor system: glial cell line-derived neurotrophic factor (GDNF), insulin-like growth factors (IGFs), and cardiotrophin-1 (CT-1)...
  32. Quinn H Hogan; Fiscal Year: 2015
    ..The modified MSCs used in these translational trials will secrete either glial cell derived neurotrophic factor (GDNF) or interleukin 10, which have demonstrated efficacy in preventing or reversing neuropathic pain when delivered by ..
  33. Molecular profiling of gamma motor neuron development
    NEIL ALAN SHNEIDER; Fiscal Year: 2011
    ..We have found that g fusimotor neurons are selectively dependent on target muscle spindle-derived GDNF, and a recent study reports that fusimotor neurons are also selectively dependent on GDNF signaling in ..
  34. Genetic analysis of the neurotrophin receptor p75 in neural development
    Kuo Fen Lee; Fiscal Year: 2012
    ..DRG neurons are lost in adult mutants, including a significant number of glial cell-derived neurotrophic factor (GDNF)-dependent c-Ret+IB4+ nociceptive neurons...
  35. AXONAL GROWTH IN THE CHRONICALLY INJURED SPINAL CORD
    John D Houle; Fiscal Year: 2010
    ..the current funding period further defined the neuroprotective role of glial cell line-derived neurotrophic factor (GDNF) after an acute injury, the use of matrix-degrading enzymes to modify a spinal cord injury site, and the response ..
  36. rAAV-GDNF to study mesolimbic control of body mass
    Ronald J Mandel; Fiscal Year: 2012
    ..by applicant): We have previously discovered that over-expression of glial cell line-derived neurotrophic factor (GDNF) via adeno-associated virus (rAAV) in the nigrostriatal tract in leads to highly significant weight loss in intact ..
  37. The Molecular Mechanisms of the GDNF-mediated Decrease in Alcohol Consumption
    Somayeh Ahmadiantehrani; Fiscal Year: 2010
    ..The GDNF signaling pathway plays a role in the regulation of alcohol consumption...
  38. Heart-Brain Retraining: Forced Aerobic exercise for Stroke Rehabilitation
    SUSAN MARIE LINDER; Fiscal Year: 2013
    ..of neurotrophic factors including brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF)...
  39. APOPTOSIS IN SUBSTANTIA NIGRA
    Robert E Burke; Fiscal Year: 2010
    ..III and IV two important fundamental issues in the neurobiology of glial cell line-derived neurotrophic factor (GDNF) for dopamine neurons...
  40. SHANTHI K SRINIVASAN; Fiscal Year: 2016
    ..Recently we discovered that (i) GDNF transgenic mice when fed a high fat diet resist weight gain and development of hepatic steatosis, despite similar ..
  41. ERIC KIRK LAU; Fiscal Year: 2014
    ..Activating Transcription Factor 2 (ATF2) is an AP1 transcription factor that functions divergently as an oncogene in melanoma and as a tumor suppressor in ..
  42. PAX2 gene targets, binding sites and function
    Patrick D Brophy; Fiscal Year: 2010
    ..Its presence is also required to activate GDNF and thus ureteric bud outgrowth...
  43. ATF2 in DNA damage response.
    ZE apos EV A RONAI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The transcription factor ATF2 contributes to cell cycle and cell death decisions upon its phosphorylation by stress kinases...
  44. RANDAL SCOT TIBBETTS; Fiscal Year: 2016
    ..Members of the CREB (cAMP response element-binding protein) family, including CREB, CREM, and ATF1, mediate transcriptional response to cAMP, calcium, and growth factors...
  45. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..on paracrine regulation of spermatogenesis by examining the in vivo function of Sertoli cell growth factors, GDNF, FGF-2 and IGF-1, which have been implicated as involved in the control of stem spermatogonial replication and ..
  46. microRNA regulation of spermatogonial stem cell self-renewal and differentiation
    RALPH LAWRENCE BRINSTER; Fiscal Year: 2013
    ..Moreover, we and others have demonstrated the importance of glial cell line-derived neurotrophic factor (GDNF) signaling in promoting SSC self-renewal and proliferation...
  47. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..dependent on HDACs during metanephric development;2) Determine the contribution of HDAC1/2 to the regulation of the Gdnf-Ret-Wnt11 pathway;and 2) Identify HDAC-sensitive gene regulatory networks in the MM and UB lineages...
  48. FRANKLIN D COSTANTINI; Fiscal Year: 2014
    ..One cause of low nephron number is a branching defect that reduces the number of UB tips. Signaling by GDNF through the Ret receptor tyrosine kinase is critical for UB formation and branching...
  49. Impact of MC1R Functional Variants on the DNA Damage Response of Human Melanocyte
    SANCY ANN LEACHMAN; Fiscal Year: 2013
    ..the impact of different MC1R variants on the MAP kinases and three of their downstream transcription factors NRF2, ATF2 and USF-1 that regulate the expression of antioxidant genes, DNA repair and apoptosis genes, and the pigmentary ..
  50. Phenotyping pain in a mouse model of pancreatic cancer
    Brian M Davis; Fiscal Year: 2012
    ..g., to abdominal skin). SA2: Test the hypothesis that PDAC increases neurotrophic factors (e.g. NGF, artemin, GDNF) and induces hypertrophy of visceral afferents ...
  51. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013
    ..It has also been found that suppression of cell proliferation and activation of Activating Transcription Factor 2 (ATF2) are independent of TGF-[unreadable] signaling following epithelium debridement...
  52. Kalipada Pahan; Fiscal Year: 2016
    ..While neurotrophins (NGF, NT-3, NT-4/5, and BDNF) and glial cell line-derived neurotrophic factor (GDNF)-related factors (GDNF, neurturin) do not increase myelinogenesis, ciliary neurotrophic factor (CNTF) induces a ..
  53. Sanjay Jain; Fiscal Year: 2016
    ..Glial cell line-derived neurotrophic factor (GDNF), its coreceptor GFR11 and receptor tyrosine kinase RET constitute a signaling system that is critical for ..
  54. Genetic Control of Ureter and Kidney Development
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
    ..b>GDNF is a mesenchymally-derived growth factor that signals to the ureteric bud epithelium via the Ret receptor tyrosine ..
  55. JENNIFER MARIE CHOW; Fiscal Year: 2016
    ..RET is a receptor tyrosine kinase that is the receptor for the glial cell-line deried neurotrophic factor (GDNF) family of neurotrophins...
  56. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ..2) Myofibroblast differentiation involves multiple TGFp signaling pathways including TAK1/p38/ATF2 and PI3-kinase/Akt that control myofibroblast differentiation and survival...
  57. DECIPHERING ROLES OF GDNF-GFRA1 RET SIGNALING IN NORMAL AND INJURED KIDNEY
    Sanjay Jain; Fiscal Year: 2012
    ..Glial cell line-derived neurotrophic factor (GDNF), its coreceptor Gfra1 and receptor Ret constitute a signaling system that is critical for kidney development...
  58. FRANKLIN D COSTANTINI; Fiscal Year: 2016
    ..This project will focus on the cellular events that are regulated by the secreted factor GDNF, which signals through the Ret receptor tyrosine kinase...
  59. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    SUSAN LYNN SEMPLE-ROWLAND; Fiscal Year: 2012
    ..of apoptosis, XIAP), and neurotrophic (rod derived cone viability factor, RdCVF;glial-derived neurotrophic factor, GDNF) therapies...
  60. Neurotrophin Drug Development for Parkinson's Disease
    William M Pardridge; Fiscal Year: 2012
    ..most potent protective factor for this area of the brain is the neurotrophin, glial derived neurotrophic factor (GDNF)...
  61. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2012
    ..Our studies on the transcription factor ATF2 suggest its oncogenic role in melanoma...
  62. HUCBC modulation of Alzheimer's-like pathology and behavioral changes
    Jun Tan; Fiscal Year: 2012
    ..Additional studies showed that HUCBC induce production of host neurotrophins including NGF, BDNF, GDNF, and NT2/3...
  63. Soluble Neuregulins in Neuromuscular and Peripheral Nerve Development
    Jeffrey A Loeb; Fiscal Year: 2013
    ..sensory and motor neuron axons in response to Schwann cell and muscle-derived neurotrophic factors such as BDNF and GDNF, and that this pathway is regulated by protein kinase C...
  64. AGE INDUCED CHANGES IN MONOAMINE PRESYNAPTIC FUNCTION
    Greg Gerhardt; Fiscal Year: 2002
    ..regenerative/protective effects of two putative dopaminotrophic factors, glial cell-derived neurotrophic factor (GDNF) and Neurturin, on dopamine neurons in young and aged Fischer 344 rats...
  65. GDNF in the Enteric Nervous System
    Yun Xia; Fiscal Year: 2007
    ..The research is directed to understanding the role of glial derived neurotropic factor (GDNF) in the enteric nervous system...
  66. NEUROTROPHINS AND AN ANIMAL MODEL OF FIBROMYALGIA
    ALICE LARSON; Fiscal Year: 2003
    ..by the enzyme thiamine monophosphatase (TMPase) and are supported by glial derived neurotrophic factor (GDNF)...
  67. Macrophage Gene Therapy of Neurodegenerative Diseases
    Senlin Li; Fiscal Year: 2007
    ..the highly prevalent Parkinson's disease (PD), local delivery of glial cell line-derived neurotrophic factor (GDNF) has been found beneficial...
  68. DEVELOPMENT OF NEURONS IN GUT--GROWTH FACTORS
    MILES EPSTEIN; Fiscal Year: 2001
    ..A knockout of the gene for Glial Derived Neurotrophic Factor (GDNF) and for its receptor Ret results in similar phenotypes...