GATA-1

Summary

Gene Symbol: GATA-1
Description: GATA binding protein 1
Alias: ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT, erythroid transcription factor, GATA-binding factor 1, NF-E1 DNA-binding protein, erythroid transcription factor 1, globin transcription factor 1, nuclear factor, erythroid 1, transcription factor GATA1
Species: human

Top Publications

  1. ncbi Transcription factor GATA-1 and Down syndrome leukemogenesis
    Andrew G Muntean
    Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Leuk Lymphoma 47:986-97. 2006
  2. doi Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 115:4367-76. 2010
  3. ncbi Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription
    L I Zon
    Division of Hematology, Children s Hospital, Boston, MA 02115
    Blood 81:3234-41. 1993
  4. pmc A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction
    C D Trainor
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Mol Cell Biol 16:2238-47. 1996
  5. ncbi FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
    A P Tsang
    Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:109-19. 1997
  6. ncbi hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation
    M Holmes
    Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 274:23491-8. 1999
  7. pmc Essential and instructive roles of GATA factors in eosinophil development
    Ryutaro Hirasawa
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Exp Med 195:1379-86. 2002
  8. ncbi Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
    Joshua Wechsler
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 32:148-52. 2002
  9. ncbi Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein
    Jian Du
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 277:43481-94. 2002
  10. ncbi Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage
    Kinuko Ohneda
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Acta Haematol 108:237-45. 2002

Research Grants

  1. John D Crispino; Fiscal Year: 2016
  2. Zhe Li; Fiscal Year: 2015
  3. Genetic modulators of erythro-megakaryocytic development
    Stella T Chou; Fiscal Year: 2012
  4. Gerd A Blobel; Fiscal Year: 2016
  5. Carolyn A Felix; Fiscal Year: 2014
  6. John D Crispino; Fiscal Year: 2016
  7. LEONARD IRA ZON; Fiscal Year: 2016
  8. Mortimer Poncz; Fiscal Year: 2015
  9. DON MICHAEL WOJCHOWSKI; Fiscal Year: 2016
  10. Gerd A Blobel; Fiscal Year: 2016

Detail Information

Publications214 found, 100 shown here

  1. ncbi Transcription factor GATA-1 and Down syndrome leukemogenesis
    Andrew G Muntean
    Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Leuk Lymphoma 47:986-97. 2006
    ..Future studies to define the entire class of genes dysregulated by mutations in GATA1 will provide important insights into the etiology of these malignancies...
  2. doi Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 115:4367-76. 2010
    ....
  3. ncbi Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription
    L I Zon
    Division of Hematology, Children s Hospital, Boston, MA 02115
    Blood 81:3234-41. 1993
    ..The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins...
  4. pmc A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction
    C D Trainor
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Mol Cell Biol 16:2238-47. 1996
    ..We propose that GATApal is important for positive regulation of GATA-1 expression in erythroid cells...
  5. ncbi FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
    A P Tsang
    Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:109-19. 1997
    ..These findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors...
  6. ncbi hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation
    M Holmes
    Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 274:23491-8. 1999
    ..Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser...
  7. pmc Essential and instructive roles of GATA factors in eosinophil development
    Ryutaro Hirasawa
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Exp Med 195:1379-86. 2002
    ..Taken together, our findings establish essential and instructive roles of GATA factors in eosinophil development. GATA-1 and GATA-2 could be novel molecular targets for therapeutic approaches to allergic inflammation...
  8. ncbi Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
    Joshua Wechsler
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 32:148-52. 2002
    ..in GATA1, encoding the essential hematopoietic transcription factor GATA1 (GATA binding protein 1 or globin transcription factor 1)...
  9. ncbi Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein
    Jian Du
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 277:43481-94. 2002
    ..Our findings identify novel combinatorial protein-protein interactions for GATA-1, PU.1, and C/EBPepsilon isoforms in eosinophil gene transcription that include GATA-1/PU.1 synergy and repressor activity for C/EBPepsilon(27)...
  10. ncbi Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage
    Kinuko Ohneda
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Acta Haematol 108:237-45. 2002
    ..In addition, recent studies identified several human inherited hematopoietic disorders that are caused by mutations in cis-acting GATA binding motifs or mutations in GATA-1 itself...
  11. ncbi Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis
    Gina Mundschau
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Blood 101:4298-300. 2003
    ..We recently reported that mutations in the transcription factor GATA1 are associated with DS-AMKL...
  12. ncbi RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation
    Kamaleldin E Elagib
    Department of Pathology, University of Virginia, Charlottesville, VA 22908 0904, USA
    Blood 101:4333-41. 2003
    ..By contrast, RUNX1-ETO inhibition of GATA function may constitute a potential mechanism for the blockade of erythroid and megakaryocytic differentiation seen in leukemias with t(8;21)...
  13. ncbi Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21
    Liat Rainis
    Department of Pediatric Hemato Oncology, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel 52621
    Blood 102:981-6. 2003
    ..These findings suggest that acquired intrauterine inactivating mutations in GATA1 and generation of GATA1s cooperate frequently with trisomy 21 in initiating megakaryoblastic proliferation, but are insufficient for progression to AMKL...
  14. pmc GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Jeffrey A Grass
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:8811-6. 2003
    ..Such a mechanism is predicted to be critical for the control of hematopoiesis...
  15. ncbi The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Division of Pediatric Hematology Oncology, Children s Hospital of Michigan, Detroit, Michigan, USA
    Cancer Res 64:728-35. 2004
    ..Additional identification of the mechanisms of differential expression of genes encoding enzymes involved in ara-C metabolism between DS and non-DS myeloblasts may lead to improvements in AML therapy...
  16. pmc Ski negatively regulates erythroid differentiation through its interaction with GATA1
    Nobuhide Ueki
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Mol Cell Biol 24:10118-25. 2004
    ..We propose that Ski cooperates in the process of transformation in erythroid cells by interfering with GATA1 function, thereby contributing to erythroleukemia...
  17. pmc GATA1 function, a paradigm for transcription factors in hematopoiesis
    Rita Ferreira
    Department of Cell Biology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 25:1215-27. 2005
  18. pmc GATA-1 forms distinct activating and repressive complexes in erythroid cells
    Patrick Rodriguez
    Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    EMBO J 24:2354-66. 2005
    ..Based on these findings, we suggest a model for the different roles of GATA-1 in erythroid differentiation...
  19. pmc Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
    Zahra Kadri
    Department of d Hématologie, Institute Cochin, INSERM U56, CNRS UMR 8104, Université René Descartes Hospital Cochin, Paris, France
    Mol Cell Biol 25:7412-22. 2005
    ..These findings provide the first example of a chain of coupling mechanisms between the binding of erythropoietin to its receptor and GATA-1-dependent gene expression...
  20. pmc Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute of Environmental Sciences, Wayne State University, Detroit, MI 48201, USA
    Blood 107:1570-81. 2006
    ....
  21. ncbi Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome
    G Xu
    1Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan
    Leukemia 20:1002-8. 2006
    ..Thus, our data indicate that physical interaction and synergy between GATA1 and RUNX1 are retained in DS-AMKL, although it is still possible that increased RUNX1 activity plays a role in the development of leukemia in DS...
  22. pmc Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters
    Francesca Bosè
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
    Mol Cell Biol 26:3942-54. 2006
    ..This may contribute to the functional cooperation between these factors and provide an explanation for the important role of ubiquitous CP2 in the regulation of erythroid genes...
  23. pmc Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression
    Michael E Layon
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03756, USA
    J Mol Biol 366:737-44. 2007
    ..These results imply that GATA-1 is sufficient to direct chromatin structure reorganization within the beta-globin LCR and an erythroid pattern of gene expression in the absence of other hematopoietic transcription factors...
  24. pmc GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription
    Yuan Yeh Kuo
    Institute of Biochemistry and Molecular Biology, National Taiwan University, College of Medicine, Taipei, Taiwan, Republic of China
    Mol Cell Biol 27:4261-72. 2007
    ..These findings illuminate the role of Gfi-1B in GATA-1-mediated transcription in the survival aspect of erythroid cells...
  25. ncbi Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML
    H Hasle
    Leukemia 22:1428-30. 2008
  26. pmc The role of transcriptional activator GATA-1 at human beta-globin HS2
    Youngran Cho
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609 735, Korea
    Nucleic Acids Res 36:4521-8. 2008
    ....
  27. doi Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia
    Rosa M Ayala
    Servicio de Hematologia, Hospital Universitario 12 de Octubre, Madrid, Espana
    Am J Hematol 84:79-86. 2009
    ..Our study has identified expression of EKLF as a factor with a favorable impact on prognosis in AML...
  28. pmc Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes
    Stefania Bottardi
    Maisonneuve Rosemont Hospital Research Center, Maisonneuve Rosemont Hospital, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 29:1526-37. 2009
    ..Since the absence of Ikaros also affects GATA-1 recruitment to GATA-2 promoter, we propose that the combinatorial effect of Ikaros and GATA-1 is not restricted to globin gene regulation...
  29. pmc GATA-1 associates with and inhibits p53
    Cecelia D Trainor
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 114:165-73. 2009
    ..Based on these findings, we conclude that inhibition of the p53 pathway by GATA-1 may be essential for erythroid cell development and survival...
  30. pmc Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis
    Zahra Kadri
    CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    PLoS Biol 7:e1000123. 2009
    ..These findings clarify the previously suspected cell-autonomous role of pRb during erythropoiesis and may provide a unifying molecular mechanism for several mouse phenotypes and human diseases associated with GATA-1 mutations...
  31. pmc Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy
    Tohru Fujiwara
    University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research, Madison, 53705, USA
    Mol Cell 36:667-81. 2009
    ..These results establish fundamental principles underlying GATA factor mechanisms in chromatin and illustrate a complex network of considerable importance for the control of hematopoiesis...
  32. doi Blasts in transient leukaemia in neonates with Down syndrome differentiate into basophil/mast-cell and megakaryocyte lineages in vitro in association with down-regulation of truncated form of GATA1
    Jun Miyauchi
    Department of Pathology and Laboratory Medicine, Tokyo Dental College Ichikawa General Hospital, 5 11 13 Sugano, Ichikawa, Chiba ken, Japan
    Br J Haematol 148:898-909. 2010
    ....
  33. pmc Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
    Jan Henning Klusmann
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Genes Dev 24:1659-72. 2010
    ..Our study underscores context-dependent requirements during oncogenesis, and explains resistance to transformation of ostensibly similar adult progenitors...
  34. doi Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia
    Rika Kanezaki
    Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Blood 116:4631-8. 2010
    ..001) and lower white blood cell counts (P = .004). Our study indicates that quantitative differences in mutant protein levels have significant effects on the phenotype of TAM and warrants further investigation in a prospective study...
  35. pmc Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia
    Vijay G Sankaran
    Broad Institute, Cambridge, MA, USA
    J Clin Invest 122:2439-43. 2012
    ..no known pathogenic mutations for DBA and identified a mutation in the gene encoding the hematopoietic transcription factor GATA1. This mutation, which occurred at a splice site of the GATA1 gene, impaired production of the full-..
  36. pmc AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL
    M J Stankiewicz
    Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Leukemia 27:1339-47. 2013
    ..The contribution of aberrant AKT signaling during the ontogeny of Down syndrome-transient myeloproliferative disorder/AMKL indicates that AKT is a therapeutic target in this form of AML...
  37. ncbi GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome
    Johann K Hitzler
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, ON, Canada
    Blood 101:4301-4. 2003
    ..Recently mutations of the gene encoding the hematopoietic transcription factor GATA1 were shown to be specific for AMKL of Down syndrome...
  38. ncbi Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome
    Marianne E Greene
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL, USA
    Blood Cells Mol Dis 31:351-6. 2003
    ..To determine whether mutations in the hematopoietic transcription factor GATA1 are associated with leukemia, we assayed for alterations in the GATA1 gene in bone marrow samples from ..
  39. ncbi Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
    Zhe Li
    Division of Hematology Oncology, Childrens Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 37:613-9. 2005
    ....
  40. doi Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations
    Oliver Tunstall-Pedoe
    Department of Haematology, Imperial College London and Imperial Healthcare NHS Trust, London, United Kingdom
    Blood 112:4507-11. 2008
    ..These data indicate that T21 itself profoundly disturbs FL hemopoiesis and they provide a testable hypothesis to explain the increased susceptibility to GATA1 mutations in DS-AMKL and DS-associated transient myeloproliferative disorder...
  41. ncbi Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
    K E Nichols
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA
    Nat Genet 24:266-70. 2000
    ..Our findings underscore the importance of FOG-1:Gata-1 associations in both megakaryocyte and erythroid development, and suggest that other X-linked anaemias or thrombocytopenias may be caused by defects in GATA1...
  42. ncbi Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells
    E Ashihara
    Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Cell Physiol 171:343-56. 1997
    ..Therefore, activation of the expression of the Epo receptor gene and activation of the erythroid differentiation program are two independent events in normal hematopoiesis...
  43. doi Definitive erythropoiesis in chicken yolk sac
    Hiroki Nagai
    Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Dev Dyn 237:3332-41. 2008
    ..It remains unclear whether yolk sac derived hematopoietic progenitors that do not undergo erythropoiesis in the yolk sac may take up intraembryonic niches and contribute to erythropoietic stem cell population after hatching...
  44. ncbi Real-time monitoring of stress erythropoiesis in vivo using Gata1 and beta-globin LCR luciferase transgenic mice
    Mikiko Suzuki
    Graduate School of Comprehensive Human Sciences, the Center for Tsukuba Advanced Research Alliance TARA, Japan Science and Technology Corporation, University of Tsukuba
    Blood 108:726-33. 2006
    ....
  45. doi Primitive erythropoiesis in the mammalian embryo
    James Palis
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, New York 14642, USA
    Int J Dev Biol 54:1011-8. 2010
    ..This surprising finding indicates that the primitive erythroid lineage is indeed mammalian, rather than non-mammalian, in character...
  46. ncbi Uroporphyrinogen III synthase. An alternative promoter controls erythroid-specific expression in the murine gene
    G I Aizencang
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 275:2295-304. 2000
    ..Thus, housekeeping and erythroid-specific transcripts are expressed from alternative promoters of a single mouse URO-synthase gene...
  47. ncbi GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
    J Natl Cancer Inst 97:226-31. 2005
    ....
  48. ncbi Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice
    Lucia Centurione
    Department of Biomorphology, University G D Annunzio, Chieti, Italy
    Blood 104:3573-80. 2004
    ..We suggest that such an increased and pathologic neutrophil emperipolesis may represent one of the mechanisms leading to myelofibrosis by releasing fibrogenic MK cytokines and neutrophil proteases in the microenvironment...
  49. pmc Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development
    Kinuko Ohneda
    Department of Pharmacy, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370 0033, Japan
    J Biol Chem 284:30187-99. 2009
    ..5-kbp region of the Gata1 gene. These data provide compelling evidence that the G(5) string is necessary for Gata1 gene expression in vivo and ZBP-89 is the functional trans-acting factor for this cis-acting region...
  50. pmc Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression
    Roy Drissen
    Medical Research Council Molecular Haematology Unit, John Radcliffe Hospital, Oxford, UK
    Blood 115:3463-71. 2010
    ..5 and mHS-25/6 collectively regulate erythroid Gata1 expression, demonstrating lineage-specific differences in Gata1 cis-element use important for development of these 2 cell types...
  51. ncbi Induction of differentiation of avian erythroblastosis virus-transformed erythroblasts by the protein kinase inhibitor H7: analysis of the transcription factor EF1
    R H Nicolas
    Chester Beatty Laboratories, Institute of Cancer Research, London
    Cell Growth Differ 2:129-35. 1991
    ..mechanism by which the differentiation occurs, we have characterized and analyzed the levels of the erythroid transcription factor EF1, originally described as a factor binding to the beta H-globin promoter...
  52. ncbi fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis
    Pascal Songhet
    University of Cologne, Institute for Developmental Biology, Koln, Germany
    Dev Dyn 236:633-43. 2007
    ..As its knockdown in zebrafish changes expression of gata1, a gene involved in hematopoietic stem cell decisions, FGF1 should be considered to play a role in the pathogenesis of del(5q) syndrome...
  53. pmc Structural and functional analysis of the Entamoeba histolytica EhrabB gene promoter
    Mónica Romero-Díaz
    Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, A, P, 14 740 México, DF 07360, Mexico
    BMC Mol Biol 8:82. 2007
    ..However, the transcription regulation in this parasite is poorly understood...
  54. pmc Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development
    Elias T Zambidis
    Division of Immunology and Hematopoiesis, Sidney Kimmel comprehensive Cancer Center at John Hokins, The John Hopkins School of Medicine, Baltimore, MD, USA
    Blood 106:860-70. 2005
    ....
  55. pmc Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium
    Craig H Pratt
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Vis 14:1414-28. 2008
    ..Thus, the purpose of the present study was to identify TFs that may play a role in this process...
  56. doi Human parvovirus B19 infection and autoimmunity
    Claudio Lunardi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Autoimmun Rev 8:116-20. 2008
    ..Moreover the VP peptide shares similarity with the transcription factor GATA1 that plays an essential role in megakaryopoiesis and in erythropoiesis...
  57. pmc Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation
    M Zingariello
    Department of Biomorphology, University of Chieti, Chieti, Italy
    Biotech Histochem 85:157-70. 2010
    ..These observations support the hypothesis that P-selectin and von Willebrand factor may ensure differential release of the alpha-granule content in response to external stimuli...
  58. ncbi Human uroporphyrinogen-III synthase: genomic organization, alternative promoters, and erythroid-specific expression
    G Aizencang
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genomics 70:223-31. 2000
    ..Thus, human URO-synthase expression is regulated during erythropoiesis by an erythroid-specific alternative promoter...
  59. pmc Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA
    Darren L Bates
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309 0215, USA
    J Mol Biol 381:1292-306. 2008
    ..These findings significantly advance our understanding of the structure and function of GATA and provide an important framework for further investigating the in vivo mechanisms of GATA-dependent gene regulation...
  60. pmc Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development
    Andrew G Muntean
    Ben May Institute for Cancer Research, Univeristy of Chicago, IL, USA
    Blood 106:1223-31. 2005
    ..These studies show that GATA-1 is required for both normal regulation of proliferation and terminal maturation of megakaryocytes, and further, that these functions can be uncoupled by mutations in GATA1...
  61. ncbi GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells)
    M Jasinski
    Division of Hematology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 98:2248-55. 2001
    ..These animals will be valuable to further investigate the consequences of GPI-anchor deficiency on erythroid/megakaryocytic cells...
  62. ncbi Mechanisms and implications of platelet discoid shape
    Joseph E Italiano
    Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 101:4789-96. 2003
    ..Platelets derived from mice lacking the transcription factor GATA1 show similar defects, probably as a direct consequence of absent beta1-tubulin...
  63. ncbi The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development
    Alvin C H Ma
    Division of Hematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Exp Hematol 35:368-73. 2007
    ..However, its role in hematopoiesis during embryonic development is currently unclear. In this study, we examined this issue using morpholino (MO) gene knockdown in zebrafish embryos..
  64. pmc The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription
    Osamu Tanabe
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2832-44. 2007
    ....
  65. pmc Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish
    Ting Xi Liu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Exp Hematol 35:230-9. 2007
    ..We investigated the role of CCAAT enhancer-binding protein-alpha (C/EBPalpha) during zebrafish embryonic blood development...
  66. doi Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
    Dani Bercovich
    Human Molecular Genetics and Pharmacogenetics Laboratory, Migal Galilee Biotechnology Centre, Kiryat Shmona, and Tel Hai Academic College, Israel
    Lancet 372:1484-92. 2008
    ..We tested the hypothesis that mutations in JAK2 might be a common molecular event in acute lymphoblastic leukaemia associated with Down's syndrome...
  67. doi Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes
    Paul S Hartley
    Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Br J Haematol 146:185-92. 2009
    ..These findings imply that circadian clock gene expression regulates platelet turnover in mammals...
  68. doi A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera
    Alvin C H Ma
    Department of Medicine, The University of Hong Kong, Hong Kong
    Exp Hematol 37:1379-1386.e4. 2009
    ..In this study, we generated a zebrafish ortholog of human JAK2(V617F) (referred herewith jak2a(V581F)) by site-directed mutagenesis and examined its relevance as a model of human PV...
  69. pmc Removal of the spleen in mice alters the cytokine expression profile of the marrow micro-environment and increases bone formation
    Fabrizio Martelli
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Ann N Y Acad Sci 1176:77-86. 2009
    ..These results confirm the role of megakaryocytes as regulator of bone formation in mice and suggest that a cross-talk between the spleen and marrow may regulate the total numbers of hemopoietic niches present in an animal...
  70. pmc CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin
    Maria Verrucci
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    J Cell Physiol 225:490-9. 2010
    ..These results indicate that Aplidin effectively alters the natural history of myelofibrosis in Gata1(low) mice and suggest this drug as candidate for clinical evaluation in PMF...
  71. ncbi DNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobin
    S Ottolenghi
    Dipartimento di Genetica e di Biologia dei Microrganismi Università degli Studi di Milano, Italy
    Hemoglobin 13:523-41. 1989
    ..might operate and HPFH might additionally be related to loss of binding to the distal CCAAT box region of either NFE1 (-117 HPFH) or of the ubiquitous CCAAT displacement protein-CDP (13 nucleotides deletion)...
  72. ncbi Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements
    Astrid Borchert
    Institute of Biochemistry, Humboldt University Medical School Charité, Monbijoustrasse 2, 10117 Berlin, Germany
    J Biol Chem 278:2571-80. 2003
    ..The decision, which GPx isoform is expressed in a given cell, appears to be made by alternative splicing of a joint primary transcript...
  73. ncbi Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2
    Tomo Terano
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto, Japan
    Exp Hematol 33:641-51. 2005
    ..To elucidate the functional role of two LIM domains in LMO2, we introduced deletion or mutation in each of the LIM domains and analyzed their phenotypic effects on the hematopoietic system when overexpressed in vivo or in vitro...
  74. pmc Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish
    Lisa J McReynolds
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Hematol 36:1604-1615. 2008
    ..Functions for this pathway in adult hematopoiesis have been challenging to probe in other models...
  75. pmc The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice
    Ramiro E Toribio
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210, USA
    FASEB J 24:1947-57. 2010
    ..The down-regulation of Runx1, Runx2, and Sox9 indicates that PTHrP is a modulator of transcriptional activation during stem cell commitment...
  76. ncbi [Oncogenes and leukemia: history and perspectives]
    Sylvie Gisselbrecht
    Département d Hématologie de l Institut Cochin, INSERM U 567, CNRS UMR 8104, bâtiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 19:201-10. 2003
    ..Treatment of leukemia could therefore benefit from new therapeutic approaches targeting the function of specific oncogene products as already demonstrated for CML and acute promyelocytic leukemia...
  77. ncbi Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development
    Genevieve Kinna
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Mech Dev 123:277-87. 2006
    ..Hence, the primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development...
  78. ncbi Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome
    David S Brink
    Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO 63104 1003, USA
    Adv Anat Pathol 13:256-62. 2006
    ..The pathogenetic role of trisomy 21 in DS-TL is unclear. Though indications for chemotherapy in DS-TL have not been firmly established, the blasts of DS-TL are sensitive to low-dose cytosine arabinoside...
  79. doi Mosaic Down syndrome-associated acute myeloid leukemia does not require high-dose cytarabine treatment for induction and consolidation therapy
    Kazuko Kudo
    Division of Hematology and Oncology, Shizuoka Children s Hospital, Aoi ku, Shizuoka, Japan
    Int J Hematol 91:630-5. 2010
    ..7%, respectively. Our retrospective study reveals that patients with mosaic DS and AMKL have a good prognosis. Reduction in intensity may work in patients with mosaic DS as well as with AML-DS...
  80. ncbi Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis
    Ryuki Hanaoka
    Laboratory of Developmental Molecular Genetics, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto, 606 8501, Japan
    Genes Cells 11:293-303. 2006
    ....
  81. pmc Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6
    Jian Xu
    Children s Hospital Boston, Massachusetts 02115, USA
    Genes Dev 24:783-98. 2010
    ..Our findings provide insight into the mechanism of BCL11A action and new clues for the developmental gene regulatory programs that function at the beta-globin locus...
  82. ncbi Tetrasomy 21 transient leukemia with a GATA1 mutation in a phenotypically normal trisomy 21 mosaic infant: case report and review of the literature
    Claudio Sandoval
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Pediatr Blood Cancer 44:85-91. 2005
    ..Transient leukemia in trisomy 21 mosaicism recapitulates the condition observed in constitutional trisomy 21 at the biological and clinical levels. Infants should be followed for the development of acute leukemia...
  83. ncbi Fractionation of mature eosinophils in GATA-reporter transgenic mice
    Kibom Kim
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Tohoku J Exp Med 220:127-38. 2010
    ..This study, therefore, proposes a useful means to study the experimental allergic and inflammatory systems...
  84. ncbi Homotypic signalling regulates Gata1 activity in the erythroblastic island
    Laura Gutierrez
    Erasmus MC, Department of Cell Biology, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Development 131:3183-93. 2004
    ..This study demonstrates the importance of intercellular signalling in regulating Gata1 activity and that this homotypic signalling between erythroid cells is crucial to normal differentiation...
  85. pmc Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer
    Kurtis Eisermann
    School of Biomedical Sciences, Kent State University, Kent, Ohio, USA
    BMC Genomics 9:337. 2008
    ..To rapidly identify coordinately expressed prostate cancer growth control genes that may be regulated by WT1, we used an in silico approach...
  86. doi The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis
    Laura M Pillay
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Dev Biol 340:306-17. 2010
    ..Our study conclusively demonstrates that Meis1 and Pbx act to specify the erythropoietic cell lineage and inhibit myelopoiesis...
  87. doi Co-culture of carp (Cyprinus carpio) kidney haematopoietic cells with feeder cells resulting in long-term proliferation of T-cell lineages
    Fumihiko Katakura
    Laboratory of Fish Pathology, Department of Veterinary Medicine, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 131:127-36. 2009
    ..These results indicate that multiple blood cells developed in the primary culture and then T-cell lineages dominantly proliferated after several passages...
  88. ncbi The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily
    D L Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, NY 14642, USA
    Endocrine 8:123-34. 1998
    ..3...
  89. ncbi Distinct roles for SCL in erythroid specification and maturation in zebrafish
    Marianne A Juarez
    Department of Internal Medicine, Division of Hematology Oncology and Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:41636-44. 2005
    ..Our results revealed that Scl participates in multiple processes requiring different levels and functions. Further, we identified an Scl hypomorphic phenotype distinct from the null state...
  90. pmc Multipotential differentiation ability of GATA-1-null erythroid-committed cells
    Kenji Kitajima
    Department of Pathology, Medical School and Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Dev 20:654-9. 2006
    ..Our data suggest that GATA-1 is a critical transcription factor to fix erythroid progenitors to the erythroid lineage...
  91. ncbi Platelet pathology in sex-linked GATA-1 dyserythropoietic macrothrombocytopenia II. Cytochemistry
    James G White
    Department of Laboratory Medicine, Pathology and Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Platelets 18:436-50. 2007
    ..The marked decrease in the number and abnormal distribution of GPIb/IX receptors may play a role in GATA-1 megathrombocyte formation...
  92. pmc Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish
    Christiane L Belele
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 114:5162-72. 2009
    The transcription factor Gata1 is required for the development of erythrocytes and megakaryocytes...
  93. doi Proteomic alterations in progeny of irradiated human liver cells
    Ya Hui Zuo
    School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou, China
    J Toxicol Environ Health A 73:520-8. 2010
    ..The upregulated expression of two proteins, mitochondrial heat-shock 60-kD protein (HSP60) and globin transcription factor 1 (GATA-1), was further confirmed by immunoblotting...
  94. pmc Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate
    Jatin Narula
    Department of Bioengineering, Rice University, Houston, Texas, USA
    PLoS Comput Biol 6:e1000771. 2010
    ....
  95. doi ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene
    Jing Chen
    Key State Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
    Biochem J 458:171-83. 2014
    ..In conclusion the results of the present study demonstrate that ZNF16 plays an important role in erythropoiesis and megakaryocytopoiesis via its regulation of the c-Kit/c-Raf/MEK/ERK/c-Jun/HEY1/GATA1 cascade. ..
  96. doi EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300
    Wei Wei Zheng
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Stem Cells 32:2278-89. 2014
    ..Microarray analysis suggested that EDAG knockdown selectively inhibits GATA1-activated target genes. These data provide novel insights into EDAG in regulation of erythroid differentiation...
  97. pmc Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
    Irina Elcheva
    Primate Research Center, University of Wisconsin Madison
    J Vis Exp . 2015
    ..The protocol includes hPSCs transduction procedures and post-transduction analysis of HE and blood progenitors. ..
  98. doi Should any genetic defect affecting α-granules in platelets be classified as gray platelet syndrome?
    Alan T Nurden
    Institut de Rhythmologie et de Modélisation Cardiaque, Plateforme Technologique d Innovation Biomédicale, Hopital Xavier Arnozan, Pessac, France
    Am J Hematol 91:714-8. 2016
    ..Am. J. Hematol. 91:714-718, 2016. © 2016 Wiley Periodicals, Inc. ..
  99. doi The genetic landscape of paediatric de novo acute myeloid leukaemia as defined by single nucleotide polymorphism array and exon sequencing of 100 candidate genes
    Linda Olsson
    Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Br J Haematol 174:292-301. 2016
    ..Twelve genes (BCOR, CEBPA, FLT3, GATA1, KIT, KRAS, NOTCH1, NPM1, NRAS, PTPN11, SMC3 and TP53) were recurrently mutated. We conclude that SNP-A and deep sequencing analyses complement the cytogenetic diagnosis of paediatric AML. ..
  100. ncbi Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor
    D I Martin
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 338:435-8. 1989
    ..The form of HPFH we studied here is an inherited disorder which can be ascribed to the action of a cell-specific DNA-binding factor on a mutant promoter...

Research Grants47

  1. John D Crispino; Fiscal Year: 2016
    ..The research described in this proposal will greatly expand our insights into how loss of the N-terminus of GATA1 alters erythropoiesis and will benefit patients with congenital anemia and DS-AMKL. ..
  2. Zhe Li; Fiscal Year: 2015
    ..It is expected that these studies will significantly enhance our understanding of the role of IGF/IGF1R signaling in blood development, and of how its activation contributes to leukemia in a cellular context-dependent manner. ..
  3. Genetic modulators of erythro-megakaryocytic development
    Stella T Chou; Fiscal Year: 2012
    ..abstract_text> ..
  4. Gerd A Blobel; Fiscal Year: 2016
    ..Moreover, we study mechanisms by which cells "remember" their identity throughout the cell cycle. Progress is this area promises novel approaches to treat blood-related disorders including leukemias and anemias. ..
  5. Carolyn A Felix; Fiscal Year: 2014
    ..The exploitation of zebrafish to model the functions of human MLL in the regulation of normal and malignant blood cell development will streamline future inroads to new molecularly targeted therapies for patients with MLL leukemia. ..
  6. John D Crispino; Fiscal Year: 2016
    ....
  7. LEONARD IRA ZON; Fiscal Year: 2016
    ....
  8. Mortimer Poncz; Fiscal Year: 2015
    ..cells at the Meg-erythroid progenitor (MEP) stage to form self-replicating cells by knockdown of the transcription factor GATA1. Upon re-induction of GATA1, these MEP cells will complete differentiation into Megs...
  9. DON MICHAEL WOJCHOWSKI; Fiscal Year: 2016
    ..Proposed work promises to discover and characterize novel regulators of erythroblast and RBC production as potentially drugable E3 ligase complexes;and as a new RBC progenitor niche in bone marrow with unique expansion potential. ..
  10. Gerd A Blobel; Fiscal Year: 2016
    ..The hematopoietic transcription factor GATA1, an acetylated protein, is essential for the differentiation and commitment of several hematopoietic ..
  11. ROBERT FRANK PAULSON; Fiscal Year: 2016
    ..These studies will provide key basic information concerning the regulation of stress erythropoiesis, which can be built upon to develop new therapies to treat anemia. ..
  12. Eosinophils and lung immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2013
    ....
  13. Differentiation of Th2 cytokine-producing innate cells
    Hua Huang; Fiscal Year: 2009
    ..For diseases such as allergic inflammation, asthma, parasitic infection, and other immune dysregulations, our findings could lead to more effective treatments. ..
  14. MOLECULAR MECHANISMS IN EVI1-INDUCED MYELOID LEUKEMIA
    Archibald Perkins; Fiscal Year: 2000
    ..This will lead to the identification of proteins that bind to EVI1, and will likely yield significant insight into the mechanism by which EVI1 effects transcriptional repression, and by which it causes disease. ..
  15. Control of lymphatic vessel growth and development by platelets
    Mark L Kahn; Fiscal Year: 2013
    ..These studies will explore a completely new cellular and molecular pathway that links lymphatic vascular biology to the blood vascular system and hemostasis with important implications for blood and lymphatic vascular human diseases. ..
  16. REGULATION OF CYTOMEGALOVIRUS INFECTION OF MONOCYTES
    JEFFERY MEIER; Fiscal Year: 2001
    ..We postulate that cis-acting regulatory mechanisms, such as the 21 bp repeats, Gf1-1 sites, and modulator, are responsible for this outcome...
  17. Transcriptional and Epigenetic Regulation of HSC Generated from iPS and ESC
    Alan Friedman; Fiscal Year: 2009
    ..By drawing upon the broad clinical expertise at Johns Hopkins, our aim is to ultimately lead a translational program for safe iPS-HSC therapies, within the overall project time frame. ..
  18. Transcription Factor GATA-1 in Erythro-Megakaryocytic Development and Leukemia
    Mitchell Weiss; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. The 4th International Conference on GATA Factors and Human Disease
    JAMES ENGEL; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2010
    ..These studies will improve our understanding of the causes of anemia and will ultimately lead to curative treatments for children and adults with sickle cell disease and thalassemia syndromes. ..
  21. Fish as Genetic Models for Aging
    Pudur Jagadeeswaran; Fiscal Year: 2002
    ..These results will also serve as preliminary data for a future NIH R01 grant application focusing on screening of Cynolebias mutants for long life span. ..
  22. TRANSCRIPTION-REGULATING VECTORS FOR ANTIVIRAL VACCINES
    Steve Cole; Fiscal Year: 2002
    ..abstract_text> ..
  23. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 2002
    ....
  24. SATURATION MUTAGENESIS OF ZEBRAFISH COAGULATION PATHWAY
    Pudur Jagadeeswaran; Fiscal Year: 2003
    ..Identification of human homologues will further our understanding of how the coagulation cascade functions in vivo, suggest novel targets for antithrombotic therapy and provide candidate genetic markers for thrombotic disease. ..
  25. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..Myelopoiesis at various levels of C/EBP activity and progenitor fate after various times of C/EBP inhibition will be assessed. ..
  26. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2004
    ..A better understanding of the initiation of mammalian hematopoiesis will provide insights into the ontogeny, regulation and expansion of HSCs, as well as the origin of leukemias and bone marrow failure syndromes. ..
  27. Autonomic nervous system control of HIV-1 replication
    Steve Cole; Fiscal Year: 2005
    ..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
  28. Red Cell Gordon Conference
    Leonard Zon; Fiscal Year: 2005
    ....
  29. Comparative Approach to the Hematopoietic Stem Cell
    Leonard Zon; Fiscal Year: 2004
    ..These studies should produce a better molecular characterization of hematopoietic and vasculogenic stem cells and could provide therapies for patients with anemia or leukemia. ..
  30. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  31. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2006
    ..These studies should improve our understanding of the basic molecular biology of globin gene regulation and could be therapeutically useful for patients with sickle anemia and thalassemia. ..
  32. Regulatory Pathways In Megakaryocyte Differentiation
    Adam Goldfarb; Fiscal Year: 2006
    ..Both cell line model systems and primary hematopoietic progenitor cells will be employed for these studies. ..
  33. Combinatorial Genomics in Cancer
    Steve W Cole; Fiscal Year: 2010
    ..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..
  34. International Society for Stem Cell Research Meeting
    Leonard Zon; Fiscal Year: 2006
    ..abstract_text> ..
  35. Initiation of Mammalian Yolk Sac Hematopoiesis
    James Palis; Fiscal Year: 2006
    ..This will ultimately lead to improvements in bone marrow transplantation for the curative treatment of congenital anemias, genetic diseases and several forms of childhood and adult cancers. ..
  36. Mount Desert Island Stem Cell Symposium
    Leonard Zon; Fiscal Year: 2008
    ..Scientific sessions will include platform presentations, a [unreadable] poster session, and a keynote address open to the general public. [unreadable] [unreadable] [unreadable]..
  37. Involvement of RUNX1 in Megakaryocytic Differentiation
    Adam Goldfarb; Fiscal Year: 2008
    ..Aim II will further explore the model in murine model systems of megakaryopoiesis, employing GATA-1 and RUNX1 knockout strains. ..
  38. Mechanisms of erythroid differentiation
    PAUL NEY; Fiscal Year: 2009
    ..Irs2 activates some of the same signaling pathways as the distal Epor. So, we will determine whether Irs2 is functionally redundant with the distal Epor in normal erythroid cells. ..
  39. Role of C/EBPalpha in MDS and MDS Progression
    Alan Friedman; Fiscal Year: 2008
    ..These data will be useful for interpreting expression data from human MDS patients and may uncover a common pathway leading to inhibition of apoptosis and progression to AML. ..
  40. Origin of HSC from Embryonic Stem Cells
    Elias Zambidis; Fiscal Year: 2008
    ..The success of these goals will lay the groundwork for characterizing human stem cells not available by any other means. ..
  41. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  42. Role of Young Thrombocytes and Their Microparticles
    Pudur Jagadeeswaran; Fiscal Year: 2008
    ..Such studies should provide insight into the role of platelet microparticles in hemostasis, mechanisms of their production and platelet maturation. ..
  43. Role of NIX in Erythroid Maturation
    PAUL NEY; Fiscal Year: 2007
    ..We propose to explore that possibility in experiments with Nix mice and other BCL2-related mouse strains. [unreadable] [unreadable] [unreadable]..
  44. Cell Cycle Regulation and Leukemogenesis by CBFb-SMMHC
    Alan Friedman; Fiscal Year: 2007
    ....
  45. Involvement of RUNX1 in Megakaryocytic Differentiation
    Adam Goldfarb; Fiscal Year: 2007
    ..abstract_text> ..
  46. NF-E2 BINDING SITES AND GLOBIN GENE REGULATION
    PAUL NEY; Fiscal Year: 2002
    ..To identify molecules that interact with these motifs, we propose yeast one/two-hybrid screens. Results from these experiments should yield important insights into the regulation of globin gene expression. ..
  47. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..