Galpha13

Summary

Gene Symbol: Galpha13
Description: G protein subunit alpha 13
Alias: G13, guanine nucleotide-binding protein subunit alpha-13, g alpha-13, guanine nucleotide binding protein (G protein), alpha 13
Species: human

Top Publications

  1. ncbi Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins
    R T Windh
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:27351-8. 1999
  2. pmc Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation
    Ashok Kumar
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 186:951-8. 2011
  3. ncbi Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor
    A C Azim
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 95:959-64. 2000
  4. ncbi The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin
    Natalia Wright
    Department of Immunology, Centro de Investigaciones Biologicas, Velazquez 144, 28006 Madrid, Spain
    J Immunol 168:5268-77. 2002
  5. ncbi Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms
    Masayuki Tobo
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    Cell Signal 19:1745-53. 2007
  6. pmc An unexpected new role of mutant Ras: perturbation of human embryonic development
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
    J Mol Med (Berl) 85:227-35. 2007
  7. ncbi Macrogolgin--a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections
    H P Seelig
    Institute of Immunology and Molecular Genetics, Karlsruhe, Germany
    J Autoimmun 7:67-91. 1994
  8. ncbi Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Cell Cycle 5:1607-11. 2006
  9. ncbi G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity
    Vyacheslav A Adarichev
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 285:C922-34. 2003
  10. ncbi [Quantitative analysis of two major secoiridoid glucosides in fruits of Ligustrum lucidum]
    Yang Li
    Institute of Pharmaceutical Research of Fourth Military Medical University, Xi an 710032, China
    Zhongguo Zhong Yao Za Zhi 33:2099-102. 2008

Research Grants

  1. Coordinate Regulation Of Nuclear DGK-theta and PLD
    DANIEL RABEN; Fiscal Year: 2009
  2. BARRY S KREUTZ; Fiscal Year: 2014
  3. Paul C Sternweis; Fiscal Year: 2016
  4. STRUCTURAL ANALYSIS OF G PROTEIN REGULATORY MECHANISMS
    STEPHEN SPRANG; Fiscal Year: 2009
  5. G Proteins and Endothelial Barrier Regulation
    Tatyana Voyno Yasenetskaya; Fiscal Year: 2004
  6. Regulation of adenylyl cyclase VII and its function in the immune system
    Paul C Sternweis; Fiscal Year: 2012
  7. BLOOD PLATELET THROMBOXANE RECEPTORS
    GUY C LEBRETON; Fiscal Year: 2013
  8. G Proteins and Protein Kinase A Anchoring
    Tatyana Voyno Yasenetskaya; Fiscal Year: 2006
  9. Fadi T Khasawneh; Fiscal Year: 2016
  10. REGULATION OF ION CHANNELS BY SPECIFIC G PROTEINS
    MALGORZATA WILK BLASZCZAK; Fiscal Year: 1999

Scientific Experts

Detail Information

Publications191 found, 100 shown here

  1. ncbi Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins
    R T Windh
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:27351-8. 1999
    ..These studies represent the first characterization of S1P receptor activity through G proteins directly and establish fundamental differences in coupling...
  2. pmc Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation
    Ashok Kumar
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 186:951-8. 2011
    ..To our knowledge, this is the first report of Gα13 as a mediator of receptor trafficking...
  3. ncbi Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor
    A C Azim
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 95:959-64. 2000
    ..The differences in subcellular distribution and previous evidence showing quantitatively divergent effects of rac and cdc42 on actin nucleation in permeabilized platelets indicate different signaling roles for these GTPases...
  4. ncbi The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin
    Natalia Wright
    Department of Immunology, Centro de Investigaciones Biologicas, Velazquez 144, 28006 Madrid, Spain
    J Immunol 168:5268-77. 2002
    ..These data indicate that up-regulation by SDF-1alpha of lymphocyte adhesion mediated by alpha(4)beta(7) could contribute to lymphocyte homing to secondary lymphoid tissues...
  5. ncbi Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms
    Masayuki Tobo
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    Cell Signal 19:1745-53. 2007
    ..8. The SRE activity was further increased by extracellular acidification in a manner dependent on the G13 protein/Rho signaling pathway in HEK293 cells expressing GPR4 or other OGR1 receptor family members...
  6. pmc An unexpected new role of mutant Ras: perturbation of human embryonic development
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
    J Mol Med (Berl) 85:227-35. 2007
    ..Neoplasia-associated Ras mutations frequently affect amino acids G12, G13, or Q61 and decrease the intrinsic guanosine triphosphatase (GTPase) activity by ten- to twentyfold...
  7. ncbi Macrogolgin--a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections
    H P Seelig
    Institute of Immunology and Molecular Genetics, Karlsruhe, Germany
    J Autoimmun 7:67-91. 1994
    ..Four overlapping cross hybridizing clones (G1, G12, G13, G14) were found...
  8. ncbi Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Cell Cycle 5:1607-11. 2006
    ..Cancer-associated Ras mutations typically alter amino acids G12, G13 or Q61...
  9. ncbi G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity
    Vyacheslav A Adarichev
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 285:C922-34. 2003
    ..Here, we analyzed which signaling pathways are required for G alpha 13-induced mitogenesis or apoptosis using a novel mutant of G alpha 13...
  10. ncbi [Quantitative analysis of two major secoiridoid glucosides in fruits of Ligustrum lucidum]
    Yang Li
    Institute of Pharmaceutical Research of Fourth Military Medical University, Xi an 710032, China
    Zhongguo Zhong Yao Za Zhi 33:2099-102. 2008
    To develop an HPLC method for determination of two major secoiridoid glucosides (nuezhenoside and G13) from Fructus Ligustri Lucidi. and determinae nuezhenoside and G13 in samples from different acquisition times and different places.
  11. pmc Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands
    Shen Hu
    University of California, School of Dentistry, Los Angeles, CA 90095 1668, USA
    Arthritis Rheum 60:81-92. 2009
    ....
  12. doi New secoiridoid glucosides from Ligustrum lucidum induce ERK and CREB phosphorylation in cultured cortical neurons
    Guangmiao Fu
    Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    Planta Med 76:998-1003. 2010
    ..methyloleoside 7-ethyl ester (2), along with five known ones, oleonuezhenide (3), nuezhenide (4), oleuropein (5), G13 (6), and jaspolyside methyl ester (7), were isolated from the fruits of Ligustrum lucidum...
  13. ncbi Influence of oil contamination on in vitro bond strength of bonding agents to dental substrates
    Adriana Bona Matos
    Department of Restoratve Dentistry, Faculty of Dentistry of the University of São Paulo, Sao Paulo, SP, Brazil
    Am J Dent 21:101-4. 2008
    ..To evaluate the influence of cleaning procedures (pumice, anionic detergent and both procedures together) on the tensile bond strength of etch-and-rinse and self-etch adhesive systems to bovine enamel and dentin in vitro...
  14. ncbi Opioid receptor signalling mechanisms
    M Connor
    Department of Pharmacology, University of Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 26:493-9. 1999
    ..None of the opioid receptors interacts substantially with Gs and mu receptors do not activate Gq, G11, G12, G13, or G14. 3. Differential coupling of different opioid receptors to most types of G-proteins is marginal...
  15. ncbi Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq
    Zhi Xie
    Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0295, USA
    J Biol Chem 277:11979-86. 2002
    ..rPLD2 is activated by Galpha(q), but is inhibited by Galpha(13). Neither Ser/Thr phosphorylation nor palmitoylation is required for these effects...
  16. ncbi Interleukin 10.G microsatellite in the promoter region of the interleukin-10 gene in severe sepsis
    Qiang Shu
    Department of Cardiovascular Surgery, Children s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Chin Med J (Engl) 119:197-201. 2006
    ..This study was conducted to investigate whether IL10.G microsatellite is associated with the incidence and/or the outcome of severe sepsis...
  17. ncbi Concomitant regulation of Ca2+ mobilization and G13 expression in human erythroleukemia cells
    M C Michel
    Dept of Medicine, University of Essen, Germany
    Eur J Pharmacol 348:135-41. 1998
    ..These data are compatible with the idea that, in HEL cells, alpha2-adrenoceptors and neuropeptide Y receptors couple to inhibition of adenylyl cyclase via Gi2 while they couple to Ca2+ elevations via Gi3...
  18. ncbi Phylogenetic analyses among octocorals (Cnidaria): mitochondrial and nuclear DNA sequences (lsu-rRNA, 16S and ssu-rRNA, 18S) support two convergent clades of branching gorgonians
    Juan Armando Sánchez
    Department of Biological Sciences, 109 Cooke Hall, University at Buffalo The State University of New York, Buffalo, NY 14260, USA
    Mol Phylogenet Evol 29:31-42. 2003
    ..The INDELS in the 16S corresponded to informative signature sequences homologous to the G13 helix found in Escherichia coli...
  19. ncbi Residue analysis of tetracyclines in poultry muscle: shortcomings revealed by a proficiency test
    B J A Berendsen
    RIKILT Institute of Food Safety, Bornsesteeg 45, PO Box 230, NL 6700 AE Wageningen, The Netherlands
    Food Addit Contam 23:1141-8. 2006
    ..muscle was organized according to the guidelines of International Laboratory Accreditation Cooperation (ILAC) ILAC-G13:2000 (2000). For the proficiency test, three test materials were prepared...
  20. pmc Development and validation of DNA microarray for genotyping group A rotavirus VP4 (P[4], P[6], P[8], P[9], and P[14]) and VP7 (G1 to G6, G8 to G10, and G12) genes
    Shinjiro Honma
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
    J Clin Microbiol 45:2641-8. 2007
    ..In addition, cross-reactivity to viruses of genotype G11, G13, or G14 or P[1] to P[3], P[5], P[7], P[10] to P[12], P[16], or P[20] was not observed...
  21. ncbi Identification and characterization of RHOA-interacting proteins in bovine spermatozoa
    Sarah E Fiedler
    Department of Medicine, Oregon Health and Sciences University and Veterans Affairs Medical Center, Portland, OR 97239, USA
    Biol Reprod 78:184-92. 2008
    ..Finally, AKAP3 binding to PRKAR2 and ROPN1 is regulated by phosphorylation in vitro...
  22. ncbi Dopamine control of striatal gene expression during development: relevance to knockout mice for the dopamine transporter
    V Fauchey
    UMR CNRS 5541, Laboratoire d Histologie Embryologie, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Eur J Neurosci 12:3415-25. 2000
    ..studied the expression of these mRNAs, in relation to dopamine innervation, in normal mice from gestational day 13 (G13) to adult...
  23. ncbi Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1
    V Radhika
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 279:49406-13. 2004
    b>Galpha13, the alpha-subunit of the heterotrimeric G protein G13, has been shown to stimulate cell migration in addition to inducing oncogenic transformation...
  24. ncbi Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase
    S Bowman
    Department of Biological Sciences, Columbia University, New York, New York 10027
    J Biol Chem 266:7517-23. 1991
    ..Recently, two different complementation groups (G13, G57), consisting of yeast nuclear mutants with defective F1, have been described...
  25. pmc Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways
    C P Thomas
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Biochem J 312:151-8. 1995
    ..Western blot analysis of crude membranes from K562 cells revealed the presence of G12 alpha and G13 alpha; the other known PT-substrates, Gi1 alpha and G0 alpha, were not detected...
  26. ncbi Evidence of temperature-dependent sex determination in the European sea bass (Dicentrarchus labrax L.)
    M Pavlidis
    Institute of Marine Biology of Crete, Heraklion, Greece
    J Exp Zool 287:225-32. 2000
    ..spawned broodstock were divided at the stage of half-epiboly into three groups according to rearing temperature: G13 = 13 degrees C, G15 = 15 degrees C, and G20 = 20 degrees C...
  27. pmc Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA
    Michelle A Booden
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
    Mol Cell Biol 22:4053-61. 2002
    ..Unlike the RGS box of p115 RhoGEF, the RGS box of LARG interacts not only with G alpha 12 and G alpha 13 but also with G alpha q...
  28. pmc The influence of cytosine methylation on the chemoselectivity of benzo[a]pyrene diol epoxide-oligonucleotide adducts determined using nanoLC/MS/MS
    James Glick
    Barnett Institute and Department of Chemistry, Northeastern University, Boston, MA 02115, USA
    J Mass Spectrom 44:1241-8. 2009
    ..In all permethylated cases studied, the relative ratio for adduction was found to be G5 >> G11 > G13 > G7...
  29. pmc Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
    B Klages
    Institut fur Pharmakologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 14195 Berlin, Germany
    J Cell Biol 144:745-54. 1999
    ..In contrast to thrombin, the TXA2 mimetic U46619 led to the selective activation of G12 and G13 in Galphaq-deficient platelets indicating that these G proteins mediate TXA2 receptor-induced shape change...
  30. ncbi RNA editing of the human serotonin 5-HT2C receptor disrupts transactivation of the small G-protein RhoA
    Lori McGrew
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Pharmacol 65:252-6. 2004
    ..The non-edited human 5-HT2C receptor isoform INI activates phospholipase D via the G13 heterotrimer G-protein...
  31. pmc The NMR structure of an internal loop from 23S ribosomal RNA differs from its structure in crystals of 50s ribosomal subunits
    Neelaabh Shankar
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Biochemistry 45:11776-89. 2006
    ..All three structures have a sheared GA pair (trans Hoogsteen/sugar edge A6G13) at the equivalent of A6 and G13. The internal loop has contacts with ribosomal protein L20 and other parts of the RNA in the crystal structures...
  32. doi Polymorphisms in the promoter region of the interleukin-10 (IL-10) gene in women with cervical insufficiency
    Jennifer E Warren
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Am J Obstet Gynecol 201:372.e1-5. 2009
    ..Our objective was to determine whether polymorphisms in the promoter region of the interleukin-10 gene are more common in women with cervical insufficiency compared with controls...
  33. doi Hb Charlieu [alpha106(G13)Leu-->Pro (alpha1)]: a new phenotypically silent hemoglobin variant associated with a mild alpha-thalassemia phenotype
    Philippe Joly
    Unité de Pathologie Moléculaire du Globule Rouge, Fédération de Biochimie et de Biologie Spécialisée, Hopital Edouard Herriot, Hospices Civils and Université Claude Bernard Lyon 1, Lyon Cedex 03, France
    Hemoglobin 34:366-73. 2010
    ..Moreover, genetic counseling and patient information are required in this family to prevent potentially severe alpha-thalassemias in following generations...
  34. ncbi Transmission of Yersinia enterocolitica 4/O:3 to pets via contaminated pork
    M Fredriksson-Ahomaa
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Lett Appl Microbiol 32:375-8. 2001
    ..This study was conducted to investigate sources of Yersinia enterocolitica 4/O:3 infections in dogs and cats...
  35. ncbi Molecular mapping of genes conferring field resistance to South American Leaf Blight ( Microcyclus ulei) in rubber tree
    V Le Guen
    CIRAD, Campus agronomique, BP 701, 97387, Kourou Cedex, French Guiana
    Theor Appl Genet 108:160-7. 2003
    ..One major QTL located on linkage group g13 was detected on the RO 38 map, responsible for 36 to 89% of the phenotypic variance of resistance...
  36. doi High diversity of arbuscular mycorrhizal fungi in a boreal herb-rich coniferous forest
    Maarja Opik
    Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    New Phytol 179:867-76. 2008
    ..Sequence groups related to Glomus intraradices were most common (MO-G3 and MO-G13). Samples of H. nobilis were colonized by more AM fungal taxa (3.68 +/- 0.31) than those of O. acetosella (2...
  37. ncbi A paradigm of undernourishing and neonatal rehabilitation in the newborn rat
    Esther Perez-Torrero
    Departamento de Psicobiologia, Facultad de Psicologia, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria S N Código Postal 028040 Madrid, Spain
    Nutr Neurosci 6:113-5. 2003
    ..An underfed group came from pregnant Wistar rats fed with 50% of the diet from G6 to G12 and with 60% from G13 until G21...
  38. pmc Specificity of TRH receptor coupling to G-proteins for regulation of ERG K+ channels in GH3 rat anterior pituitary cells
    Pablo Miranda
    Departamento de Bioquimica y Biologia Molecular, Edificio Santiago Gascon, Campus del Cristo, Universidad de Oviedo, E 33006, Oviedo, Asturias, Spain
    J Physiol 566:717-36. 2005
    ..In contrast, the introduction of dominant-negative variants of Galpha13 and the small G-protein Rho caused a significant loss of the inhibitory effect of TRH on r-ERG...
  39. doi Structure and sequence motifs of siRNA linked with in vitro down-regulation of morbillivirus gene expression
    Renata Servan de Almeida
    CIRAD, UPR Contrôle des maladies, Montpellier, France
    Antiviral Res 79:37-48. 2008
    ..We also confirm that the presence of at least the sequence motifs U13, A or U19, as well as the absence of G13, cooperate to increase siRNA knockdown rates. Additionally, we observe that G11 is linked with siRNA efficacy...
  40. doi Structural insight into G-protein coupled receptor binding by apelin
    David N Langelaan
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5 Canada
    Biochemistry 48:537-48. 2009
    ..At 5 degrees C, R6-L9 retains its structuring while the functionally critical C-terminal G13-F17 region also becomes highly structured...
  41. ncbi [Efficient fusion expression of G13 domain derived from granulysin in Escherichia coli]
    Xiaoqiang Liu
    Key Laboratory of Ecological Engineering and Biotechnology of Anhui Province, School of Life Science, Anhui University, Hefei 230039, China
    Sheng Wu Gong Cheng Xue Bao 25:235-41. 2009
    The G13 domain derived from granulysin shows high antimicrobial activities against Gram-positive and Gram-negative bacteria but does not lyse Jurkat cells or liposomes...
  42. pmc The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein
    A Khanna
    Department of Biochemistry, University of Oxford, U K
    Biochem J 319:81-9. 1996
    b>G13 is a single-copy gene lying approx. 75 kb centromeric of the complement gene cluster in the class III region of the human MHC. The gene spans approx. 17 kb of DNA and has been shown to encode mRNA of approx. 2...
  43. ncbi Differential effect toward inhibition of papain and cathepsin C by recombinant human salivary cystatin SN and its variants produced by a baculovirus system
    C C Tseng
    Divisions of Basic Sciences and of Restorative and Prosthodontic Sciences, Room 1027 S, College of Dentistry, New York University, 345 East 24th Street, New York, New York 10010 4086, USA
    Arch Biochem Biophys 380:133-40. 2000
    ..Collectively, these results suggest that the N-terminal G12-G13 residues of CsnSN are not essential for papain inhibition but play a role in cathepsin C inhibition; residues Q56-..
  44. pmc Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
    K Haze
    HSP Research Institute, Kyoto Research Park, 17 Chudoji minami, Shimogyo ku, Kyoto 600 8813, Japan
    Biochem J 355:19-28. 2001
    ..This protein encoded by the G13 (cAMP response element binding protein-related protein) gene is constitutively synthesized as a type II ..
  45. ncbi How wet should dentin be? Comparison of methods to remove excess water during moist bonding
    G D Pereira
    Gama Filho University, School of Dentistry, Rio de Janeiro, Brazil
    J Adhes Dent 3:257-64. 2001
    ..The aim of this study was to evaluate the shear bond strength of two adhesive systems when applied on dentin surfaces with different degrees of wetness...
  46. ncbi 5-Hydroxytryptamine 4(a) receptor is coupled to the Galpha subunit of heterotrimeric G13 protein
    Evgeni G Ponimaskin
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut Universität Göttingen, Humboldtallee 23, D 37073 Gottingen, Germany
    J Biol Chem 277:20812-9. 2002
    ..These data suggest that by activating 5-HT(4(a)) receptor-G(13) pathway, serotonin plays a prominent role in regulating neuronal architecture in addition to its classical role in neurotransmission...
  47. ncbi The N-linked glycan g15 within the V3 loop of the HIV-1 external glycoprotein gp120 affects coreceptor usage, cellular tropism, and neutralization
    Svenja Polzer
    Bernhard Nocht Institute for Tropical Medicine, 20359, Hamburg, Germany
    Virology 304:70-80. 2002
    ..neutralization of X4, R5, and R5X4 tropic HIV-1 mutants, which are lacking N-linked glycosylation sites for glycans g13, g14, g15, and g17 in the V3 loop region of gp120...
  48. ncbi G13 is an essential mediator of platelet activation in hemostasis and thrombosis
    Alexandra Moers
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Nat Med 9:1418-22. 2003
    ..We conclude that G(13)-mediated signaling processes are required for normal hemostasis and thrombosis and may serve as a new target for antiplatelet drugs...
  49. ncbi Characterization of G proteins involved in activation of nonselective cation channels and arachidonic acid release by norepinephrine/alpha1A-adrenergic receptors
    Yoshifumi Kawanabe
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Am J Physiol Cell Physiol 286:C596-600. 2004
    ..For these purposes, we used U73122, an inhibitor of phospholipase C (PLC), and dominant negative mutants of G12 and G13 (G12G228A and G13G225A, respectively). U73122 failed to inhibit NSCCs activation by norepinephrine...
  50. ncbi Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy
    Sabine Grüner
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Circulation 110:2946-51. 2004
    ..The activating platelet collagen receptor, glycoprotein VI (GP VI), may serve as a powerful antithrombotic target because its inhibition or absence results in profound protection against arterial thrombosis but no major bleeding in mice...
  51. ncbi [Reorganization of microtubule system in pulmonary endothelial cells in response to thrombin treatment]
    K M Smurova
    Tsitologiia 46:695-703. 2004
    ..Overexpression of activated G12, G13, Gi and Gq proteins, which are involved in thrombin receptor-mediated signaling, resulted in increasing stress ..
  52. pmc Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts
    Shingo Nakayamada
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan
    Arthritis Res Ther 7:R476-84. 2005
    ..an N-terminal regulator of the G-protein signaling domain of p115RhoGEF) and by the C-terminal fragments of Galpha13 (an inhibitor of the interaction of receptors with G13)...
  53. ncbi The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4
    Wenfu Tan
    Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 281:39542-9. 2006
    ....
  54. ncbi Geobacter pickeringii sp. nov., Geobacter argillaceus sp. nov. and Pelosinus fermentans gen. nov., sp. nov., isolated from subsurface kaolin lenses
    Evgenya S Shelobolina
    Department of Microbiology, University of Massachusetts, Morrill Science Center IVN, Amherst, MA 01003, USA
    Int J Syst Evol Microbiol 57:126-35. 2007
    ..Two novel dissimilatory Fe(III)-reducing bacteria, strains G12(T) and G13(T), were isolated from sedimentary kaolin strata in Georgia (USA)...
  55. ncbi Regulation of apoptosis signal-regulating kinase 1 degradation by G alpha13
    Mikhail A Kutuzov
    Department of Pharmacology, University of Illinois, 909 S Wolcott Ave, Chicago, IL 60612, USA
    FASEB J 21:3727-36. 2007
    ..We have shown previously that alpha subunits of heterotrimeric G12 and G13 proteins stimulate ASK1 kinase activity and ASK1-dependent apoptosis...
  56. ncbi [Fannin-Lubbock II hemoglobin [beta111(G13)Val -> Leu y beta119(GH2)Gly -> Asp]: description of 4 new cases]
    F Ataúlfo González
    Servicio de Hematologia y Hemoterapia, Hospital Clinico San Carlos, Madrid, Espana
    Med Clin (Barc) 129:379-81. 2007
    ..The aim of this work is the molecular description of a 4 new cases of the hemoglobin Fannin-Lubbock II, which presents the substitution of 2 amino acids in the same beta globin chain...
  57. pmc Decreased aminoacylation in pathology-related mutants of mitochondrial tRNATyr is associated with structural perturbations in tRNA architecture
    Luc Bonnefond
    Architecture et Reactivite de l ARN, Universite Louis Pasteur de Strasbourg, CNRS, 67084 Strasbourg, France
    RNA 14:641-8. 2008
    ..of G15 and A22 in the tertiary network of human mt-tRNA(Tyr) via nonclassical Watson-Crick G15-C48 and G13-A22 pairings...
  58. doi Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, Japan
    Mutat Res 642:57-67. 2008
    ....
  59. pmc Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6
    Keisuke Yanagida
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Univerfsity of Tokyo, Tokyo, Japan
    J Biol Chem 284:17731-41. 2009
    ..Here we report that p2y5 is a novel LPA receptor coupling to the G13-Rho signaling pathway...
  60. pmc The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin
    Nebojsa Knezevic
    Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Exp Med 206:2761-77. 2009
    ..PAR1-induced dissociation of Galpha subunit from heterotrimeric Gq and G12/G13 proteins is known to signal the increase in endothelial permeability...
  61. pmc Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells
    Yutaro Obara
    Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    PLoS ONE 6:e24284. 2011
    ..These results suggest that LPI, and not cannabinoids, causes neurite retraction in differentiated PC12 cells via a GPR55, G(13) and RhoA signaling pathway...
  62. doi A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers
    Attila A Seyhan
    Systems Biology, Global Biotherapeutics, Pfizer Inc, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Mol Biosyst 8:1553-70. 2012
    ..Their use as patient or treatment selection biomarkers could make the application of anti-ErbB therapeutics more clinically effective...
  63. doi Small molecule-enrichment analysis in response to osmotic stimuli in the intervertebral disc
    H Ma
    Department of Orthopaedic Surgery, Shanghai First Rehabilitation Hospital, Shanghai, P R China
    Genet Mol Res 11:3668-75. 2012
    ..We anticipate that our results will be used to generate hypotheses for laboratory, patient, and population-based studies...
  64. pmc Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins
    Frank Medina
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 288:11325-33. 2013
    ..A direct mechanism for hormonal regulation of the RhoA-type GTPases is their modulation by the G12 and G13 proteins via RH (RGS homology) containing RhoGEFs...
  65. doi Genomic sequence analysis of the MHC class I G/F segment in common marmoset (Callithrix jacchus)
    Azumi Kono
    Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    J Immunol 192:3239-46. 2014
    ..Six putatively functional Caja-G and Caja-F genes (Caja-G1, Caja-G3, Caja-G7, Caja-G12, Caja-G13, and Caja-F4), 13 pseudogenes related either to Caja-G or Caja-F, three non-MHC genes (ZNRD1, PPPIR11, and RNF39), ..
  66. pmc A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance
    Junfeng Xia
    Authors Affiliations Department of Biomedical Informatics
    Mol Cancer Ther 13:1918-28. 2014
    ..that identifies well-known specific recurrent mutations in five driver genes: BRAF (affecting V600), NRAS (G12, G13, and Q61), KIT (W557, V559, L576, K642, and D816), GNAQ (Q209), and GNA11 (Q209)...
  67. doi Activity and specificity of the human SUV39H2 protein lysine methyltransferase
    Maren Kirstin Schuhmacher
    Institute of Biochemistry, Stuttgart University, Pfaffenwaldring 55, 70569 Stuttgart, Germany
    Biochim Biophys Acta 1849:55-63. 2015
    ..on H3 comprising T6-K14, with highly specific readout of R8, S10, T11 and G12 and partial specificity at T6, A7, G13 and K14...
  68. doi GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway
    Calvin R Justus
    Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Exp Cell Res 334:100-13. 2015
    ..Altogether our results indicate that through the G12/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling. ..
  69. doi Influence of polishing protocol on flexural properties of several dental composite resins
    Robert Ramirez-Molina
    Department of Operative Dentistry, School of Dentistry, University of Los Andes, Merida, Venezuela
    Acta Odontol Latinoam 28:64-71. 2015
    ..XR HD, G7 ice, G8 Vit-L-escenceR, G9 GrandioR, G10 TPHR3, G11 AmelogenR Plus, G12 Brilliant Enamel; G13 Filtek™ Z100 and randomly divided into four groups according to the finishing system: C control, J JiffyR, SS ..
  70. pmc The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination
    Jagan R Muppidi
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143
    J Exp Med 212:2213-22. 2015
    ....
  71. doi Higher efficiency soluble prokaryotic expression, purification, and structural analysis of antimicrobial peptide G13
    Yuanyuan Che
    School of Life Sciences, Anhui University, Hefei, Anhui, 230601, PR China
    Protein Expr Purif 119:45-50. 2016
    b>G13 is a 19-residue cationic antimicrobial peptide derived from granulysin...
  72. pmc Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma
    Nitin K Agarwal
    Division of Hematopathology, Department of Pathology
    Blood 127:605-15. 2016
    ..By linking IKKβ-mediated nuclear factor-κB activity with GLI1, we identified a crosstalk between these 2 pathways that can inform the design of novel therapeutic strategies in DLBCL. ..
  73. doi Characterization of Phenacoccus solenopsis (Tinsley) (Homoptera: Pseudococcidae) Resistance to Emamectin Benzoate: Cross-Resistance Patterns and Fitness Cost Analysis
    M B S Afzal
    Dept of Entomology, Fac of Agricultural Sciences and Technology, Bahauddin Zakariya Univ Multan, Multan, Pakistan
    Neotrop Entomol 45:310-9. 2016
    ..decline in emamectin resistance was observed in the resistant population when not exposed to emamectin from G7 to G13. The estimated realized heritability (h (2)) for emamectin resistance was 0.84...
  74. ncbi Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals
    Ya Han Huang
    a Department of Life Sciences, National Central University, Jhongli, Taiwan and
    J Recept Signal Transduct Res 36:633-644. 2016
    ..4 ∼ 6.8, are important to pH homeostasis, immune responses and acid-induced pain. Although G2A mediates the G13-Rho pathway in response to acid, whether G2A activates Gs, Gi or Gq proteins remains debated...
  75. pmc Single Synonymous Mutations in KRAS Cause Transformed Phenotypes in NIH3T3 Cells
    Andrew M Waters
    Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, Maryland, United States of America
    PLoS ONE 11:e0163272. 2016
    Synonymous mutations in the KRAS gene are clustered at G12, G13, and G60 in human cancers. We constructed 9 stable NIH3T3 cell lines expressing KRAS, each with one of these synonymous mutations...
  76. ncbi Multiplex KRASG12/G13 Mutation Testing of Unamplified Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using Droplet Digital Polymerase Chain Reaction
    F Janku
    Department of Investigational Cancer Therapeutics Phase I Clinical Trials Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Oncol . 2016
    ..Novel, multiplex, and accurate diagnostic systems using small amounts of DNA are needed to further the use of plasma cfDNA testing in personalized therapy...
  77. ncbi [Gastrointestinal hormones. I. Hormones of the gastrin group]
    W P Fritsch
    Z Gastroenterol 15:264-76. 1977
    ..subjects several gastrin molecules could be isolated which were nominated as "mini gastrin" (G13), "little gastrin" (G17), "big gastrin" (G34) and "big big gastrin"...
  78. ncbi In vivo assessment of architecture and micro-finite element analysis derived indices of mechanical properties of trabecular bone in the radius
    D C Newitt
    Magnetic Resonance Science Center, University of California, San Francisco 94143 1290, USA
    Osteoporos Int 13:6-17. 2002
    ..a micro-finite element model to derive the directional Young's moduli (E1, E2 and E3), shear moduli (G12, G23 and G13) and anisotropy ratios such as E1/E3...
  79. ncbi First case of a single heterozygote of an abnormal hemoglobin, Hb Stanmore, [beta111(G13)Val-->Ala]
    A Miyazaki
    Department of Clinical Pathology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 8686, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 792:23-31. 2003
    ..mass spectrometry (ESI-MS) and peptide analysis by on-line HPLC-ESI-MS-MS revealed the substitution, [beta111(G13)Val-->Ala], which was confirmed by DNA analysis. This was the second case of Hb Stanmore...
  80. ncbi Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2
    Reema Goel
    Department of Pharmacological and Physiological Sciences, St Louis University Medical School, St Louis, Missouri 63104, USA
    J Biol Chem 279:6701-10. 2004
    ..fibroblasts (IIC9 cells) express the Galpha subunits Galphas, Galphai2, Galphai3, Galphao, Galpha(q/11), and Galpha13. Consistent with reports in other cell types, alpha-thrombin stimulates a subset of the expressed G proteins in ..
  81. ncbi Real-time monitoring of receptor and G-protein interactions in living cells
    Céline Gales
    Department of Biochemistry, Universite de Montreal, P O Box 6128 Down town station, Montreal, H3C 3J7, Canada
    Nat Methods 2:177-84. 2005
    ....
  82. pmc Genomic approach to identifying the putative target of and mechanisms of resistance to mefloquine in mycobacteria
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, 105 Magruder Hall, Corvallis, OR 97331 8797, USA
    Antimicrob Agents Chemother 49:3707-14. 2005
    ..avium genomic library under the control of a strong sigma-70 (G13) promoter in M. smegmatis. Resistant clones were selected in 32 microg/ml of mefloquine (wild-type M. avium, M...
  83. ncbi Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the heterotrimeric G proteins G12 and G13
    Jingzhen Yuan
    Department of Medicine, David Geffen School of Medicine and Molecular Biology Institute, University of California, 900 Veteran Ave, Warren Hall, Rm 11 124, Los Angeles, CA 90095 1786, USA
    Cell Signal 18:1051-62. 2006
    ..Here, we show that addition of aluminum fluoride to COS-7 cells cotransfected with PKD3 and Galpha13 or Galpha12 induced PKD3 activation, which was associated with a transient plasma membrane translocation of ..
  84. ncbi The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration
    D Bian
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Oncogene 25:2234-44. 2006
    ..With the aid of p115RhoGEF-RGS, G12 and G13 minigenes to inhibit G12/13, we found that the G12/13 pathway was required for LPA-induced FAK autophosphorylation ..
  85. ncbi Differential green fluorescent protein expression from mycobacterial promoter constructs in Escherichia coli and Mycobacterium marinum
    Kelly Gall
    Department of Anatomy, Microbiology and Pathology, University of Minnesota Medical School, Duluth, MN 55812, USA
    FEMS Microbiol Lett 255:301-7. 2006
    The Mycobacterium marinum G13 promoter is a sigma 70-like promoter that is more active by green fluorescent protein (gfp) differential fluorescence induction (DFI) assays when M...
  86. ncbi G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles
    Dawei Wang
    Department of Physiology, Cornell University Weill Medical College, New York, NY 10021, USA
    J Biol Chem 281:32660-7. 2006
    ..Thus, Galpha(12)/Galpha(13) critically regulate dorsal ruffle turnover...
  87. doi Angiogenesis-related gene expression analysis in celiac disease
    Ainara Castellanos-Rubio
    Immunogenetics Research Laboratory, Endocrinology, Diabetes and Nutrition Research Group, Hospital de Cruces, Barakaldo, Basque Country
    Autoimmunity 45:264-70. 2012
    ..Finally, cell culture models are useful tools to help dissect complex responses observed in human explants...
  88. doi Proteomic analysis of microvesicles derived from human mesenchymal stem cells
    Han Soo Kim
    Department of Laboratory Medicine, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemoon Gu, Seoul 120 752, Republic of Korea
    J Proteome Res 11:839-49. 2012
    ..Therefore, the MSC-MV proteome provides a comprehensive basis for understanding the potential of MSC-MVs to affect tissue repair and regeneration...
  89. doi Complete molecular genome analyses of equine rotavirus A strains from different continents reveal several novel genotypes and a largely conserved genotype constellation
    Jelle Matthijnssens
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    J Gen Virol 93:866-75. 2012
    ..The genotype constellation of L338 was unique: G13-P[18]-I6-R9-C9-M6-A6-N9-T12-E14-H11...
  90. pmc Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
    Jens G Lohr
    Eli and Edythe Broad Institute, Cambridge, MA 02412, USA
    Proc Natl Acad Sci U S A 109:3879-84. 2012
    ..Our data provide an unbiased view of the landscape of mutations in DLBCL, and this in turn may point toward new therapeutic strategies for the disease...
  91. doi Genetic variation in a wild population of the 'sleep' passion fruit (Passiflora setacea) based on molecular markers
    C B M Cerqueira-Silva
    Departamento de Estudos Básicos e Instrumentais, Universidade Estadual do Sudoeste da Bahia, Itapetinga, BA, Brasil
    Genet Mol Res 11:731-8. 2012
    ..29 (among accessions Ps-G1 and Ps-G13) to 0.69 (among accessions Ps-G21 and Ps-G23)...
  92. pmc Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia
    PeiLin Jia
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Comput Biol 8:e1002587. 2012
    ..This approach can be applied to any other complex diseases/traits where multiple GWAS datasets are available...
  93. doi G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure
    Mikito Takefuji
    Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Circulation 126:1972-82. 2012
    ..Most G(q/11)-coupled receptors, however, can also activate G proteins of the G(12/13) family, but the role of G(12/13) in cardiac remodeling is not understood...
  94. doi The use of bur and laser for root caries treatment: a comparative study
    V Geraldo-Martins
    Universidade de Uberaba, Faculdade de Odontologia, Uberaba, Brazil
    Oper Dent 38:290-8. 2013
    ..25 W; G4: 1.5 W; G5: 1.75 W; G6: 2.0 W; G7: 2.25 W; G8: 2.5 W; G9: 2.75 W; G10: 3.0 W; G11: 3.25 W; G12: 3.5 W; G13: 3.75 W; and G14: 4.0 W...
  95. doi EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol
    Kang Jin Jeong
    Department of Pharmacology, College of Medicine, Konyang University, Daejeon 302 718, Korea
    Mol Oncol 7:121-9. 2013
    ..We observed that both Gi and G13 contribute to LPA-induced EGFR activation...
  96. pmc The genetic landscape of mutations in Burkitt lymphoma
    Cassandra Love
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    Nat Genet 44:1321-5. 2012
    ..We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene...
  97. ncbi Marginal adaptation of indirect restorations using different resin coating protocols
    Alberth David Correa Medina
    Department of Restorative Dentistry, Dental Materials Division, Piracicaba Dental School, UNICAMP University of Campinas, Piracicaba, SP, Brazil
    Braz Dent J 23:672-8. 2012
    ..The same combinations were applied to the cavities in CM: G9, G10, G11, G12, G13, G14, G15, G16, respectively. The fillings were performed with the Sinfony-System (3M/ESPE)...
  98. doi Rapid and accurate species and genomic species identification and exhaustive population diversity assessment of Agrobacterium spp. using recA-based PCR
    M Shams
    Universite de Lyon, F 69622 Lyon, France Université Lyon 1, F 69622 Villeurbanne, France
    Syst Appl Microbiol 36:351-8. 2013
    ..of Agrobacterium presently known, including 11 genomic species of the Agrobacterium tumefaciens complex (G1-G9, G13 and G14, among which only G2, G4, G8 and G14 still received a Latin epithet: pusense, radiobacter, fabrum and ..
  99. pmc Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
    Ryan D Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
    Blood 122:1256-65. 2013
    ..This study further improves our understanding of the processes and pathways involved in lymphomagenesis, and some of the pathways mutated here may indicate new avenues for therapeutic intervention. ..
  100. ncbi Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13
    M V Prasad
    Fels Institute for Cancer Research and Molecular Biology, Temple University, School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 270:18655-9. 1995
    Signal transduction pathways regulated by G12 and G13 heterotrimeric G proteins are largely unknown...
  101. ncbi A peptide corresponding to GPIIb alpha 300-312, a presumptive fibrinogen gamma-chain binding site on the platelet integrin GPIIb/IIIa, inhibits the adhesion of platelets to at least four adhesive ligands
    D B Taylor
    Department of Biology, Memphis State University, Tennessee 38152
    J Biol Chem 267:11729-33. 1992
    ..K., and Taylor, D. B. (1990) Thromb. Res. 60, 291-309). Here we report that the peptide GPIIb alpha 300-312 (G13) inhibits platelet aggregation and binds Fg and Vn...

Research Grants19

  1. Coordinate Regulation Of Nuclear DGK-theta and PLD
    DANIEL RABEN; Fiscal Year: 2009
    ..Two heterotrimeric GTP-binding proteins, Gq and G13, and the lipid kinase PI 3-kinase mediate thrombin activation of this pathway...
  2. BARRY S KREUTZ; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The G12 family of heterotrimeric G proteins, which consists of G12 and G13, has been shown to mediate signals from GPCRs to RhoA activation...
  3. Paul C Sternweis; Fiscal Year: 2016
    ..P115-RhoGEF and its homologs can directly modulate the exchange of GTP on RhoA when activated by the heterotrimeric G13 protein...
  4. STRUCTURAL ANALYSIS OF G PROTEIN REGULATORY MECHANISMS
    STEPHEN SPRANG; Fiscal Year: 2009
    ..we seek to determine how the RGS-RhoGEF family of Rho activators are regulated by GPCRs that act through G12 and G13 class G[unreadable] subunits (G[unreadable]12 and G[unreadable]13)...
  5. G Proteins and Endothelial Barrier Regulation
    Tatyana Voyno Yasenetskaya; Fiscal Year: 2004
    ..The activation of the alpha subunit of heterotrimeric G13 protein by thrombin in endothelial cells is critical for the activation of Rho proteins and assembly of actin ..
  6. Regulation of adenylyl cyclase VII and its function in the immune system
    Paul C Sternweis; Fiscal Year: 2012
    ..This is the first demonstration that the G12/G13 subclass of G proteins can regulate cAMP responses and of a specific function for AC7...
  7. BLOOD PLATELET THROMBOXANE RECEPTORS
    GUY C LEBRETON; Fiscal Year: 2013
    ..The molecular and functional consequences of G13 phosphorylation...
  8. G Proteins and Protein Kinase A Anchoring
    Tatyana Voyno Yasenetskaya; Fiscal Year: 2006
    ..b>Galpha13 is expressed ubiquitously, whereas AKAP 110 expression is restricted to particular locations, including ..
  9. Fadi T Khasawneh; Fiscal Year: 2016
    ..This finding suggests that the IL1 domain of TPR participates in receptor coupling to Gq, but not G13. Similarly, the role of other IL regions in G-protein coupling will be determined by examining the effects of their ..
  10. REGULATION OF ION CHANNELS BY SPECIFIC G PROTEINS
    MALGORZATA WILK BLASZCZAK; Fiscal Year: 1999
    ..both insensitive to pertussis toxin (PTX): the G-protein Gq/11 mediates the activation of K+ current, while G13 mediates the inhibition of the ICa V...
  11. Microtubules in lung endothelial cell barrier regulation
    Alexander Verin; Fiscal Year: 2009
    ..Thrombin-induced signaling involves activation of heterotrimeric G-proteins, G12 and G13. We have demonstrated that depletion of subunits of these proteins attenuates thrombin-induced EC permeability, ..
  12. EFFECT OF HORMONES ON SIGNAL TRANSDUCTION IN BONE
    Paula Stern; Fiscal Year: 2009
    ..is to define the mechanisms of interactions within the signaling pathway, including the interactions between G12/G13 alpha subunits of heterotrimeric G proteins and RhoA and the regulation of the pathway by calcium...
  13. Functional analysis of G alpha 12/G alpha 13 G-proteins
    Danny Dhanasekaran; Fiscal Year: 2004
    Heterotrimeric G proteins, G12 and G13 regulate critical pathways involved in cell growth, differentiation, and apoptosis...
  14. Pharmacological Study of G-proteins in Gene Regulation
    Richard Ye; Fiscal Year: 2007
    ..In Aim 1, we will investigate the signaling pathways utilized by G13 for NF-KappaB activation...
  15. The Role of Adenosine Receptors in Endothelial Cells
    Igor Feoktistov; Fiscal Year: 2005
    ..In Specific Aim I we will explore the coupling of A2B AdoR to other G proteins, in particular Gq, G12 and G13, which our preliminary studies suggest are important in the upregulation of angiogenic factors...
  16. Inhibitors of PAR1-G13 Interface for Arthersclerosis
    Annette Gilchrist; Fiscal Year: 2002
    ..For this application, we have identified peptides based on the carboxyl-terminal sequence of G13 that bind to PAR1...
  17. RECEPTOR COUPLING TO G12 AND G13
    David Manning; Fiscal Year: 2006
    The heterotrimeric G proteins G12 and G13 have received considerable attention for their roles in the regulation of gene transcription, Na+/H+ exchange, and changes in cell contractility and shape...
  18. PACS From 20th to 21st Century
    SAMUEL DWYER; Fiscal Year: 2002
    ..The goal of this G13 Publication Grant is to prepare a critical review of PACS and address important questions related to future ..
  19. Ethanol, neurotrophins, and thalamocortical matching
    SANDRA MOONEY; Fiscal Year: 2006
    ..abstract_text> ..