galectin 3

Summary

Gene Symbol: galectin 3
Description: galectin 3
Alias: CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, galectin-3, 35 kDa lectin, IgE-binding protein, MAC-2 antigen, advanced glycation end-product receptor 3, carbohydrate-binding protein 35, galactose-specific lectin 3, laminin-binding protein, lectin L-29, lectin, galactoside-binding, soluble, 3
Species: human

Top Publications

  1. ncbi Localization of galectin-3 in normal and diseased pancreatic tissue
    C Schaffert
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha 68198 4525, USA
    Int J Pancreatol 23:1-9. 1998
  2. pmc Galectin-3: A novel substrate for c-Abl kinase
    Vitaly Balan
    Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Biochim Biophys Acta 1803:1198-205. 2010
  3. ncbi Galectins. Structure and function of a large family of animal lectins
    S H Barondes
    Department of Psychiatry, University of California, San Francisco 94143
    J Biol Chem 269:20807-10. 1994
  4. ncbi Value and level of galectin-3 in acute myocardial infarction patients undergoing primary percutaneous coronary intervention
    Tzu Hsien Tsai
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Atheroscler Thromb 19:1073-82. 2012
  5. doi Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH
    A Rogier van der Velde
    Department of Cardiology, Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Heart Fail 6:219-26. 2013
  6. ncbi Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation
    Fei Yu
    Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 277:15819-27. 2002
  7. pmc Galectin-3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancers
    Pratima Nangia-Makker
    Tumor Progression and Metastasis, Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 67:11760-8. 2007
  8. doi Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents
    Teak Chin Cheong
    Gastric Cancer Branch, Division of Translational and Clinical Research I, National Cancer Center Research Institute and Hospital, Madu1 dong, Ilsandong gu, Goyang si, Gyeonggi Do, Korea
    Cancer Sci 101:94-102. 2010
  9. ncbi Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid
    E D Rossi
    Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy
    Histopathology 48:795-800. 2006
  10. doi Serum Cyfra 21.1 and galectin-3 protein levels in relation to immunohistochemical cytokeratin 19 and galectin-3 expression in patients with thyroid tumors
    Tijana Isic
    Institute for the Application of Nuclear Energy, INEP, University of Belgrade, Banatska 31b, 11080 Zemun, Belgrade, Serbia
    J Cancer Res Clin Oncol 136:1805-12. 2010

Research Grants

  1. Bacterial IgE-binding proteins
    ERVIN FAULMANN; Fiscal Year: 2003
  2. ACTIVE H+ TRANSPORT IN URINARY ACIDIFICATION
    Qais Al Awqati; Fiscal Year: 2006
  3. Shiga toxin uptake mechanisms and intracellular action
    Olga Kovbasnjuk; Fiscal Year: 2010
  4. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
  5. Fu Tong Liu; Fiscal Year: 2014
  6. Protein inhibitor of galectin-3 to limit fibrosis after myocardial infarction
    MATTHEW LAWRENCE SPRINGER; Fiscal Year: 2013
  7. Michael Demetriou; Fiscal Year: 2014
  8. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
  9. Susan L Deutscher; Fiscal Year: 2016
  10. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2004

Detail Information

Publications253 found, 100 shown here

  1. ncbi Localization of galectin-3 in normal and diseased pancreatic tissue
    C Schaffert
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha 68198 4525, USA
    Int J Pancreatol 23:1-9. 1998
    ..Galectin-3 is expressed in both human and hamster pancreatic tumors and tumor cell lines and this expression is increased over normal...
  2. pmc Galectin-3: A novel substrate for c-Abl kinase
    Vitaly Balan
    Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Biochim Biophys Acta 1803:1198-205. 2010
    ..Further investigation is needed to better understand the functional significance of the novel tyrosine phosphorylated sites of galectin-3...
  3. ncbi Galectins. Structure and function of a large family of animal lectins
    S H Barondes
    Department of Psychiatry, University of California, San Francisco 94143
    J Biol Chem 269:20807-10. 1994
  4. ncbi Value and level of galectin-3 in acute myocardial infarction patients undergoing primary percutaneous coronary intervention
    Tzu Hsien Tsai
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Atheroscler Thromb 19:1073-82. 2012
    ..This study investigated the impact of the circulating galectin-3 level on the 30-day prognostic outcome in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI)...
  5. doi Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH
    A Rogier van der Velde
    Department of Cardiology, Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Heart Fail 6:219-26. 2013
    ..The importance and clinical use of repeated measurements of galectin-3 have not yet been reported...
  6. ncbi Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation
    Fei Yu
    Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 277:15819-27. 2002
    ..Taken together, these results suggest that synexin mediates galectin-3 translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation...
  7. pmc Galectin-3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancers
    Pratima Nangia-Makker
    Tumor Progression and Metastasis, Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 67:11760-8. 2007
    ..We conclude that galectin-3 cleavage is an active process during tumor progression and could be used as a simple, rapid, and reliable surrogate marker for the activities of MMPs in growing breast cancers...
  8. doi Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents
    Teak Chin Cheong
    Gastric Cancer Branch, Division of Translational and Clinical Research I, National Cancer Center Research Institute and Hospital, Madu1 dong, Ilsandong gu, Goyang si, Gyeonggi Do, Korea
    Cancer Sci 101:94-102. 2010
    ..We conclude that galectin-3 is involved in cancer progression and malignancy by modulating the expression of several relevant genes, and inhibition of galectin-3 may be an approach to improve chemotherapy of gastric cancers...
  9. ncbi Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid
    E D Rossi
    Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy
    Histopathology 48:795-800. 2006
    ..The aim of this study was to evaluate the expression of several antibodies considered to be markers of malignancy in malignant and hyperfunctioning thyroid neoplasms and to include the most effective of them in a diagnostic panel...
  10. doi Serum Cyfra 21.1 and galectin-3 protein levels in relation to immunohistochemical cytokeratin 19 and galectin-3 expression in patients with thyroid tumors
    Tijana Isic
    Institute for the Application of Nuclear Energy, INEP, University of Belgrade, Banatska 31b, 11080 Zemun, Belgrade, Serbia
    J Cancer Res Clin Oncol 136:1805-12. 2010
    ....
  11. doi Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner
    M Álvaro Berbís
    Chemical and Physical Biology Department, Centro de Investigaciones Biologicas, CSIC, 28040 Madrid, Spain
    Biochem Biophys Res Commun 443:126-31. 2014
    ..Controls with sequence scrambling underscored inherent specificity. Our studies shed light on how phosphorylation of the N-terminal tail may impact on Gal-3 function and prompt further studies using phosphorylated full-length protein. ..
  12. pmc Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma
    Yung Kuo Lee
    Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 8:e82478. 2013
    ....
  13. ncbi Malignant transformation of thyroid follicular cells by galectin-3
    Yukinori Takenaka
    Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Lett 195:111-9. 2003
    ..These results indicate the transformation of thyroid follicular cells by galectin-3 and possible involvement of galectin-3 in cell cycle...
  14. doi Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?
    Lenka Frol'ová
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, Prague 4 142 20, Czech Republic
    Inflamm Res 58:503-12. 2009
    ..It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease...
  15. pmc Tyrosine-phosphorylated galectin-3 protein is resistant to prostate-specific antigen (PSA) cleavage
    Vitaly Balan
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 287:5192-8. 2012
    ..In addition, the ratio of phosphorylated/dephosphorylated galectin-3 might be used as a complementary value to that of PSA for prognosis of prostate cancer and a novel therapeutic target for the treatment of prostate cancer...
  16. doi Herpes simplex virus type 1 infection increases the carbohydrate binding activity and the secretion of cellular galectin-3
    Ryan D King
    University of Pennsylvania, Philadelphia, 19104 6073, USA
    Arch Virol 154:609-18. 2009
    ..We propose that increased carbohydrate binding and secretion of galectin-3 contribute to an early pro-inflammatory innate immune response to HSV-1 infection...
  17. ncbi Diagnostic utility of MOC-31, HBME-1 and MOC-31 mRNA in distinguishing between carcinoma cells and reactive mesothelial cells in pleural effusions
    Ying Sun
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China
    Acta Cytol 53:619-24. 2009
    ..To evaluate the individual and combined diagnostic utility of MOC-31, HBME-1 and MOC-31mRNA in the differentiation of adenocarcinoma cells from reactive mesothelial cells in pleural effusions...
  18. doi Universal markers of thyroid malignancies: galectin-3, HBME-1, and cytokeratin-19
    Figen Barut
    Department of Pathology, Zonguldak Karaelmas University Faculty of Medicine, 67600, Kozlu, Zonguldak, Turkey
    Endocr Pathol 21:80-9. 2010
    ....
  19. doi Follicular thyroid neoplasms can be classified as low- and high-risk according to HBME-1 and Galectin-3 expression on liquid-based fine-needle cytology
    Guido Fadda
    Divisions of Anatomic Pathology and Histology Endocrinology Endocrine Surgery, Agostino Gemelli School of Medicine, Catholic University of Sacred Heart, Largo Francesco Vito, 1 00168 Rome, Italy
    Eur J Endocrinol 165:447-53. 2011
    ..In this setting immunocytochemical stainings might be helpful. The efficacy of a panel made up of HBME-1 and Galectin-3 antibodies is evaluated in cases processed by liquid-based cytology (LBC)...
  20. ncbi Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model
    Esther Lopez
    Immunology Department, Fundacion Jimenez Diaz Capio, Madrid, Spain
    J Immunol 176:1943-50. 2006
    ..Plasmid-encoding Gal-3 acts as a novel treatment for chronic asthma in mice producing nearly complete blockade of Ag responses with respect to eosinophil airway accumulation, airway hyperresponsiveness, and remodeling...
  21. ncbi Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation
    Shumei Song
    Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Gastroenterology 129:1581-91. 2005
    ..Galectin-3 modulates expression of MUC2 protein, but the specific regulatory mechanisms are unknown. This study sought to determine how galectin-3 increases MUC2 expression...
  22. pmc Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells
    Anna I Markowska
    Graduate Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 286:29913-21. 2011
    ..Finally, we observed reduced suture-induced neovascularization in the corneas of Gal3(-/-) and Mgat5(-/-) mice...
  23. ncbi Implication of galectin-3 in Wnt signaling
    Tatsuo Shimura
    Department of Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 65:3535-7. 2005
    ..The data presented here give credence to the suggestion that gal-3 is a key regulator in the Wnt/beta-catenin signaling pathway and highlight the functional similarities between gal-3 and beta-catenin...
  24. pmc Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3
    Hai Biao Jiang
    Department of Gastroenterology, Shanghai First People s Hospital affiliated to Shanghai Jiaotong University, 85 Wujin Road, Shanghai 200080, China
    World J Gastroenterol 14:2023-8. 2008
    ..To investigate the role of pancreatic stellate cells (PSCs) and galectin-3 (GAL-3) in the proliferation and infiltration of pancreatic cancer cell line SW1990...
  25. doi Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study
    Armando Bartolazzi
    Department of Pathology, St Andrea University Hospital, Rome, Italy
    Lancet Oncol 9:543-9. 2008
    ..We aimed to assess the diagnostic effect of galectin-3 expression analysis in distinguishing preoperatively benign from malignant follicular thyroid nodules when FNA findings were indeterminate...
  26. doi Loss of galectin-3 expression correlates with clear cell renal carcinoma progression and reduced survival
    Axel S Merseburger
    Department of Urology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    World J Urol 26:637-42. 2008
    ..The aim of this study was to analyze the expression of galectin-3 in clear cell renal carcinoma and to assess its prognostic significance...
  27. pmc Expression profiling of Galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry
    Alexandra A Mourad-Zeidan
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 173:1839-52. 2008
    ..Thus, Gal-3 plays an essential role during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression...
  28. ncbi X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution
    J Seetharaman
    Departments of Molecular and Medical Genetics and Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Biol Chem 273:13047-52. 1998
    ....
  29. ncbi Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3
    Cristiane Damas Gil
    Post Graduation in Morphology, São Paulo School of Medicine UNIFESP, Sao Paulo, SP, Brazil
    Cell Biol Int 30:338-44. 2006
    ..Therefore, ANXA1 and Gal-3 changed in their content and localization when neutrophils adhere to endothelia, suggesting a process of sensitive-balance between two endogenous anti- and pro-inflammatory mediators...
  30. ncbi Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation
    N Tinari
    Department of Oncology and Neurosciences, Universita G D Annunzio, Chieti, Italy
    Int J Cancer 91:167-72. 2001
    ..Because both of these galectins as well as 90K are often over-expressed in neoplasm, these interactions may occur in the setting of various carcinomas and contribute to their progression and metastasis...
  31. pmc Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein
    J W Park
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    Nucleic Acids Res 29:3595-602. 2001
    ....
  32. ncbi MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-galectin-3 interactions
    Sophia K Khaldoyanidi
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    J Biol Chem 278:4127-34. 2003
    ....
  33. ncbi HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc
    Yan Zeng
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Bone Miner Res 22:1851-61. 2007
    ..Our studies indicate that HIF-1 alpha regulates galectin-3 expression by interacting with hypoxia regulatory elements in the promoter region. Finally, we show that galectin-3 serves a prosurvival role in the intervertebral disc...
  34. ncbi Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms
    M W Robertson
    Medical Biology Institute, Division of Molecular Biology, La Jolla, California 92037
    Biochemistry 29:8093-100. 1990
    ..However, after neuraminidase treatment of each human IgE, pronounced binding to epsilon BP was observed, thereby indicating that only specific IgE glycoforms can be recognized by epsilon BP...
  35. pmc Expression of galectin-3 modulates T-cell growth and apoptosis
    R Y Yang
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 93:6737-42. 1996
    ..We conclude that galectin-3 is a regulator of cell growth and apoptosis and it may function through a cell death inhibition pathway that involves Bcl-2...
  36. ncbi Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion
    H Inohara
    Tumor Progression and Metastasis Program, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 56:4530-4. 1996
    ..These results provide the first direct evidence for a Mac-2-binding protein function and suggest that it may play a role in tumor cell embolization during metastasis through interaction with galectin-3...
  37. ncbi The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter
    M M Kadrofske
    Department of Biochemistry, Michigan State University, East Lansing 48824, USA
    Arch Biochem Biophys 349:7-20. 1998
    ....
  38. ncbi Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest
    Tadashi Yoshii
    Tumor Progression and Metastasis Program, Karmanos Cancer Institute, Wayne State University, 110 E Warren Ave, Detroit, MI 48201, USA
    J Biol Chem 277:6852-7. 2002
    ..e. p21(WAF1/CIP1) and p27(KIP1) expression levels. These results demonstrate that galectin-3 phosphorylation regulates its anti-apoptotic signaling activity...
  39. ncbi Increased expression of galectin-3 in primary gastric cancer and the metastatic lymph nodes
    Junichi Miyazaki
    Second Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Oncol Rep 9:1307-12. 2002
    ..In conclusion galectin-3 might be a useful tumor marker for gastric cancers with respects to tumor progression and potentiality of lymph node metastasis especially in certain histological types of gastric cancer...
  40. ncbi Nuclear localization of Galectin-3 in transformed thyroid cells: a role in transcriptional regulation
    Igor Paron
    Dipartimento di Scienze e Tecnologie Biomediche, P le Kolbe 1, Universita Degli Studi di Udine, 33100 Udine, Italy
    Biochem Biophys Res Commun 302:545-53. 2003
    ....
  41. pmc NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:3580-90. 2004
    ....
  42. ncbi Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3
    Stephane Califice
    Metastasis Research Laboratory, Experimental Cancer Research Center, University of Liege, Belgium
    Oncogene 23:7527-36. 2004
    ..Thus, our study demonstrates that galectin-3 exerts opposite biological activities according to its cellular localization: nuclear galectin-3 plays antitumor functions and cytoplasmic galectin-3 promotes tumor progression...
  43. pmc Alterations in galectin-3 expression and distribution correlate with breast cancer progression: functional analysis of galectin-3 in breast epithelial-endothelial interactions
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Ave, Detroit, Michigan 48201, USA
    Am J Pathol 165:1931-41. 2004
    ..Such a localized expression of galectin-3 in cancer cells proximal to the stroma could lead to increased invasive potential by inducing novel or better interactions with the stromal counterparts...
  44. ncbi Decreased galectin-3 expression during the progression of cervical neoplasia
    Jeong Won Lee
    Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, 135 710, Seoul, Korea
    J Cancer Res Clin Oncol 132:241-7. 2006
    ..We investigated whether the expression of galectin-3 is associated with the progression of cervical neoplasia...
  45. pmc Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis
    Barbara Cecchinelli
    Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy
    Mol Cell Biol 26:4746-57. 2006
    b>Galectin 3 (Gal-3), a member of the beta-galactoside binding lectin family, exhibits antiapoptotic functions, and its aberrant expression is involved in various aspects of tumor progression...
  46. ncbi Visualization of galectin-3 oligomerization on the surface of neutrophils and endothelial cells using fluorescence resonance energy transfer
    Julie Nieminen
    Glycobiology Laboratory, Research Centre for Infectious Diseases, Faculty of Medicine, Laval University, Quebec G1V 4G2, Canada
    J Biol Chem 282:1374-83. 2007
    ..Furthermore, our data suggest that galectin-3 lattices are robust and could, thus, be involved, as previously proposed, in the restriction of receptor clustering...
  47. ncbi Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
    Eunju Yang
    Chemical Genomics Laboratory, Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 749, Republic of Korea
    Biochem Biophys Res Commun 363:336-41. 2007
    ..Finally, exogenous addition of galectin-3 into HUVECs induced angiogenesis in an APN-dependent manner, implying that APN is a crucial mediator of galectin-3-induced angiogenesis in endothelial cells...
  48. ncbi Involvement of decreased Galectin-3 expression in the pathogenesis and progression of prostate cancer
    Axel S Merseburger
    Department of Urology, Eberhard Karls University Tubingen, Germany
    Prostate 68:72-7. 2008
    ....
  49. doi Expression of galectin-3 in the tumor immune response in colon cancer
    Patrick Dumont
    Laboratory of Pathology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Lab Invest 88:896-906. 2008
    ..These data suggest an involvement of gal-3 in the response of colon cancer cells to proinflammatory stimuli, such as the conditioned medium from activated macrophages...
  50. doi Identification of galectin-3 and mucin-type O-glycans in breast cancer and its metastasis to brain
    M A Mayoral
    Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurologia y Neurocirugia, Del Tlalpan, Mexico
    Cancer Invest 26:615-23. 2008
    ....
  51. doi Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells
    Duck Woo Kim
    Department of Surgery, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Cancer Sci 99:1884-91. 2008
    ..In the presence of cell cycle synchronizing drugs, doxorubicin, etoposide, or nocodazole, suppression of galectin-3 induced cell cycle progression to G0/G1 phase...
  52. doi Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis
    E H Kang
    Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Lupus 18:22-8. 2009
    ..These findings suggest that Gal-3 might contribute to the inflammatory process in SLE...
  53. pmc Regulation of prostate cancer progression by galectin-3
    Yi Wang
    Tumor Progression and Metastasis, Karmanos Cancer Institute, School of Medicine, Wayne State University, 110 East Warren Ave, Detroit, MI 48201, USA
    Am J Pathol 174:1515-23. 2009
    ..The data obtained here implicate galectin-3 in prostate cancer progression and suggest that galectin-3 may serve as both a diagnostic marker and therapeutic target for future disease treatments...
  54. pmc Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on alpha3beta1 integrin
    Chandrassegar Saravanan
    Department of Ophthalmologyand The New England Eye Center, Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, Boston, MA 02111, USA
    J Cell Sci 122:3684-93. 2009
    ..We propose that Gal-3 promotes epithelial cell migration by cross-linking MGAT5-modified complex N-glycans on alpha3beta1 integrin and subsequently activating alpha3beta1-integrin-Rac1 signaling to promote lamellipodia formation...
  55. doi Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression
    Seok Jun Kim
    Gastric Cancer Branch, Division of Translational and Clinical Research I, National Cancer Center Research Institute and Hospital, Jungbalsan ro, Ilsandong gu, Goyang si, Gyeonggi Do, Republic of Korea
    Gastroenterology 138:1035-45.e1-2. 2010
    ..Galectin-3 induces cytoskeletal remodeling to increase cell motility, but the mechanisms of this process are not understood. We investigated the effects of galectin-3 on fascin-1, an actin-bundling protein...
  56. pmc Diagnostic utility of galectin-3 in thyroid cancer
    Connie G Chiu
    Department of Surgery, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Am J Pathol 176:2067-81. 2010
    ....
  57. doi Identification and consequences of galectin-3 expression in pituitary tumors
    A Righi
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Mol Cell Endocrinol 326:8-14. 2010
    ..Given its role in pituitary tumor cell proliferation and in apoptosis, galectin-3 may be a target for the treatment of aggressive pituitary tumors...
  58. doi Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model
    Hugo Sanchez-Ruderisch
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Germany
    FEBS J 277:3552-63. 2010
    ..A previously undescribed orchestrated fine-tuning of this effector system by a tumor suppressor is discovered...
  59. pmc Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response
    Anna I Markowska
    Department of Ophthalmology Tufts University School of Medicine, Boston, MA 02115, USA
    J Exp Med 207:1981-93. 2010
    ..in vitro and that VEGF- and bFGF-mediated angiogenic response is reduced in galectin-3 knockdown cells and Gal3(-/-) animals...
  60. pmc Mutational tuning of galectin-3 specificity and biological function
    Emma Salomonsson
    Section MIG, Department of Laboratory Medicine, Lund University, 223 62 Lund, Sweden
    J Biol Chem 285:35079-91. 2010
    ..Finally, the mutants have helped to define the differences in fine specificity shown by Xenopus, mouse, and human galectin-3 and, as such, the evidence for adaptive change during evolution...
  61. pmc Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1)
    Seok Jun Kim
    Gastric Cancer Branch, Division of Translational and Clinical Research I, National Cancer Center Research Institute and Hospital, Jungbalsan ro, Ilsandong gu, Goyang si, Gyeonggi Do, Republic of Korea
    PLoS ONE 6:e25103. 2011
    ....
  62. doi The expressions and clinical significances of tissue and serum galectin-3 in pancreatic carcinoma
    Ling Xie
    Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People s Republic of China
    J Cancer Res Clin Oncol 138:1035-43. 2012
    ..The aim of this study is to elucidate the relationship between galectin-3 and clinicopathological variables and to evaluate the clinical significance of serum galectin-3 in the diagnosis of pancreas carcinoma...
  63. doi The effect of galectin-3 genetic variants on the susceptibility and prognosis of gliomas in a Chinese population
    Hong jie Chen
    Department of Neurosurgery, Fuzhou General Hospital of Nanjing Command, Fuzhou Fujian 350025, China
    Neurosci Lett 518:1-4. 2012
    ..The results of this study suggest the SNPs at +292 A>C, not SNPs at +191 A>C, of galectin-3 gene were associated with the tumor grade and prognosis of gliomas...
  64. pmc Ligand induced galectin-3 protein self-association
    Adriana Lepur
    Microbiology, Immunology, and Glycobiology MIG Section, Department of Laboratory Medicine, Lund University, 223 62 Lund, Sweden
    J Biol Chem 287:21751-6. 2012
    ....
  65. doi Galectin-3 expression in prostate cancer and benign prostate tissues: correlation with biochemical recurrence
    Judith S Knapp
    Department of Urology, Diakonie Klinikum Stuttgart, Stuttgart, Germany
    World J Urol 31:351-8. 2013
    ..Our aim was to examine Gal-3 expression in tumor, benign tissue adjacent to the tumor (adjacent-benign) and benign prostate specimens and correlated it with biochemical recurrence...
  66. pmc Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling
    Shumei Song
    Department of Gastroenterology, Hepatology, and Nutrition, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e42699. 2012
    ..These results suggest that Gal-3 contributes to pancreatic cancer progression, in part, by binding Ras and activating Ras signaling. Gal-3 may therefore be a potential novel target for this deadly disease...
  67. pmc Galectin-3 regulates p21 stability in human prostate cancer cells
    Y Wang
    Department of Oncology, Tumor Progression and Metastasis, Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI, USA
    Oncogene 32:5058-65. 2013
    ..This study provides a unique insight into the relationship of these two molecules during prostate cancer progression, and may provide a novel therapeutic target. ..
  68. doi Higher bone marrow LGALS3 expression is an independent unfavorable prognostic factor for overall survival in patients with acute myeloid leukemia
    Chieh Lung Cheng
    Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Blood 121:3172-80. 2013
    ..001). In conclusion, BM LGALS3 expression may serve as a new biomarker to predict clinical outcome in patients with AML, and galectin-3 may serve as a potential therapeutic target in those patients with higher expression of this protein...
  69. ncbi The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity
    Heather Dawson
    Head Translational Research Unit TRU, Institute of Pathology, University of Bern, Murtenstrasse 31, Room L414, CH 3010 Bern, Switzerland
    Anticancer Res 33:3053-9. 2013
    ..In addition, the multifunctional members of this group can be intracellular, binding to distinct proteins. The presence of galectins and galectin reactivity were exemplarily studied in the present article...
  70. pmc Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages
    F T Liu
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 147:1016-28. 1995
    ..galectin-3, has been known as epsilon BP for its IgE-binding activity and as Mac-2, a macrophage surface antigen, CBP35, CBP30, L-29, and L-34...
  71. pmc Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma
    M M Lotz
    Laboratory of Cancer Biology, Deaconess Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3466-70. 1993
    The Mac-2 lectin (carbohydrate binding protein 35) is a soluble, 32- to 35-kDa phosphoprotein that binds galactose-containing glycoconjugates...
  72. ncbi The second intron of the human galectin-3 gene has a strong promoter activity down-regulated by p53
    J Raimond
    Laboratoire de Biochimie des Glycoconjugués et Lectines Endogènes, Centre de Biophysique Moléculaire du CNRS, Orleans, France
    FEBS Lett 363:165-9. 1995
    ..This promoter activity is down-modulated by wild-type p53 but not by a mutated form of p53...
  73. ncbi L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I
    M E Huflejt
    Department of Psychiatry, University of California, San Francisco 94143
    J Biol Chem 268:26712-8. 1993
    ....
  74. ncbi Human galectin-3 is a novel chemoattractant for monocytes and macrophages
    H Sano
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 165:2156-64. 2000
    ..These results indicate that galectin-3 is a novel chemoattractant for monocytes and macrophages and suggest that the effect is mediated at least in part through a PTX-sensitive (G protein-coupled) pathway...
  75. ncbi Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands
    N Mazurek
    Gastrointestinal Cancer Research Laboratory, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Biol Chem 275:36311-5. 2000
    ....
  76. ncbi Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected
    Constance M John
    Center for Immunochemistry and VA Medical Center, San Francisco, CA 94121, USA
    Cell Microbiol 4:649-62. 2002
    ..We conclude that because of its location and affinity for gonococcal LOS galectin-3 could play a role in gonococcal infection...
  77. ncbi Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells
    Huei Min Lin
    Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA
    Oncogene 21:8001-10. 2002
    ..The present study reveals a growth promoting activity of galectin-3 through cyclin D(1) induction, and suggests a novel function of nuclear galectin-3 in the regulation of gene transcription...
  78. ncbi Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity
    Galit Elad-Sfadia
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    J Biol Chem 279:34922-30. 2004
    ..These experiments established a novel and specific mechanism controlling the duration and selectivity of signals of active K-Ras, which is extremely important in many human tumors...
  79. ncbi Galectin-3 expression in non-small cell lung carcinoma
    Fabio Puglisi
    Clinical Oncology, University of Udine, Italy
    Cancer Lett 212:233-9. 2004
    ..In the present study, concomitant expression of nuclear galectin-3 and TTF-1 was independently associated with a worse clinical outcome (HR 2.0; P = 0.01)...
  80. ncbi Multifaceted role of galectin-3 on human glioblastoma cell motility
    Charles Debray
    Laboratory of Histology, Faculty of Medicine, Universite Libre de Bruxelles, Belgium
    Biochem Biophys Res Commun 325:1393-8. 2004
    ....
  81. ncbi On the role of galectin-3 in cancer apoptosis
    S Nakahara
    Tumor Progression and Metastasis Program, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Apoptosis 10:267-75. 2005
    ..We also suggest potential directions for further analyses of this multifunctional protein...
  82. pmc Galectin-3 regulates myofibroblast activation and hepatic fibrosis
    Neil C Henderson
    Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, 51 Little France Crescent, EH16 4SA Edinburgh, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 103:5060-5. 2006
    ..Finally, in vivo siRNA knockdown of Galectin-3 inhibited myofibroblast activation after hepatic injury and may therefore provide an alternative therapeutic approach to the prevention and treatment of liver fibrosis...
  83. pmc Galectin-3 expression correlates with apoptosis of tumor-associated lymphocytes in human melanoma biopsies
    Mariana Rodríguez Zubieta
    Fundacion Instituto Leloir, Buenos Aires, Argentina
    Am J Pathol 168:1666-75. 2006
    ..Considering the complex process of cancer immunoediting, various interacting factors must be considered...
  84. ncbi Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans
    Luciana Kohatsu
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 177:4718-26. 2006
    ....
  85. ncbi Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells
    Nachman Mazurek
    Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:21337-48. 2007
    Galectin-3 (GAL3), a beta-galactoside-binding lectin, confers chemoresistance to a wide variety of cancer cell types. It may exhibit anti- or pro-apoptotic activity depending on the nature of the stimulus...
  86. ncbi Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells
    Yihui Shi
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Int J Cancer 121:1175-81. 2007
    ..The combined inhibition of Wnt-2 and Gal-3 may be of superior therapeutic advantage to inhibition by either one of them, giving rise to a potential development of novel drugs for the targeted treatment of colorectal cancer...
  87. pmc The role of galectin-3 in cancer drug resistance
    Tomoharu Fukumori
    Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Drug Resist Updat 10:101-8. 2007
    ..We suggest that targeting galectin-3 could improve the efficacy of anticancer drug chemotherapy in several types of cancer...
  88. ncbi [Association of galectin-3 and E-cadherin expressions with lymph node metastasis of colon cancer]
    Zong hui Wu
    Department of General Surgery, Hospital of Xi nan University, Chongqing 400715, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:1731-3. 2007
    ..To explore the correlation between the expressions of galectin-3 and E-cadherin and lymph node metastasis of colon cancer...
  89. doi Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins
    Cecilia Cederfur
    Department of Laboratory Medicine, Section MIG Microbiology, Immunology, Glycobiology, Lund University, 223 62 Lund, Sweden
    Glycobiology 18:384-94. 2008
    ....
  90. ncbi Serum level of galectin-3 in human bladder cancer
    Manabu Sakaki
    Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 55:127-32. 2008
    ..Higher expression of galectin-3 was observed in bladder cancer tissue than in normal bladder tissue. We suggest the measurement of serum galectin-3 is useful for diagnosis of bladder cancer...
  91. doi Serum galectin-1 and galectin-3 levels in benign and malignant nodular thyroid disease
    Sven Saussez
    Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons Hainaut, Mons, Belgium
    Thyroid 18:705-12. 2008
    ..The goal of this study was to determine if a difference in galectin serum levels could be detected between benign and malignant nodular thyroid diseases...
  92. pmc Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis
    Ya Zhuo
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 283:22177-85. 2008
    ....
  93. pmc Tumor-associated galectin-3 modulates the function of tumor-reactive T cells
    Weiyi Peng
    The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:7228-36. 2008
    ..These findings suggest that Gal-3 may function as an immune regulator to inhibit T-cell immune responses and promote tumor growth, thus providing a new mechanism for tumor immune tolerance...
  94. pmc RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors
    He Yu Zhang
    Department of Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Endocrine 35:101-11. 2009
    ....
  95. doi Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells
    Tamara Delaine
    Organic Chemistry, Lund University, POB 124, SE 221 00 Lund, Sweden
    J Med Chem 51:8109-14. 2008
    ..Two of the compounds were selected for testing in cell culture and were shown to have potent antimigratory effects on human PC-3 prostate and human A549 nonsmall-cell lung cancer cells...
  96. doi The immunological potential of galectin-1 and -3
    Amy Dhirapong
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, School of Medicine, Davis, CA 95616, USA
    Autoimmun Rev 8:360-3. 2009
    ..Therefore, understanding the role of galectins in achieving appropriate proliferative and effector responses to antigens will yield important insights to autoimmune diseases and delineate novel strategies for disease intervention...
  97. doi Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells
    Chi Iou Lin
    Department of Surgery, Brigham and Women s Hospital, 20 Shattuck St, Thorn 1503, Boston, MA 02115, USA
    Biochem Biophys Res Commun 379:626-31. 2009
    ..These observations support further evaluation of Gal-3 as a potential therapeutic target in patients with aggressive PTC...
  98. doi Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas
    Luca Lavra
    S Pietro Fatebenefratelli Hospital, Rome, Italy
    J Pathol 218:66-75. 2009
    ..Interference with Gal-3 expression in these cells stimulated their chemosensitivity. In conclusion, gain-of-function p53 mutant acquires the de novo ability to stimulate Gal-3 expression and to increase chemoresistance in ATCs...
  99. pmc Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface
    Qicheng Zhao
    Gastroenterology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Cancer Res 69:6799-806. 2009
    ..This provides insight into the molecular regulation of metastasis and has important implications for the development of novel therapeutic strategies for prevention of metastasis...
  100. doi The relationship between serum galectin-3 and serum markers of cardiac extracellular matrix turnover in heart failure patients
    Yen Hung Lin
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Clin Chim Acta 409:96-9. 2009
    ..However, the exact relationship is unknown in humans. We assessed the impact of galectin-3 on serum markers of cardiac extracellular matrix (ECM) turnover in HF patients...
  101. ncbi [The expression of galectin-3 and osteopontin in occult metastasis of non-small cell lung cancer]
    Yong Liang
    Department of Thoracic Surgery, Beijing Chao Yang Hospital, Beijing 100020, China
    Zhonghua Wai Ke Za Zhi 47:1061-3. 2009
    ..To study the relationship between expression of galectin-3 (Gal-3) and osteopontin (OPN) in occult metastasis in non-small cell lung cancer...

Research Grants75

  1. Bacterial IgE-binding proteins
    ERVIN FAULMANN; Fiscal Year: 2003
    ..4 billion. Allergy testing, in the clinical laboratory, represents a major market. Laboratory assays to detect IgE response to specific allergens with increased sensitivity and reduced false negative results would be advantageous. ..
  2. ACTIVE H+ TRANSPORT IN URINARY ACIDIFICATION
    Qais Al Awqati; Fiscal Year: 2006
    ..Hensin is secreted as a soluble monomer but gets polymerized by cyclophilin C, and later converted to fibers by galectin 3. Only the fiber form can bind and activate (by tyrosine phosphorylation) its receptor, which we recently ..
  3. Shiga toxin uptake mechanisms and intracellular action
    Olga Kovbasnjuk; Fiscal Year: 2010
    ..In this grant, we will characterize the mechanisms of Stx uptake by the intestinal epithelium and develop pharmacologic methods to stop this uptake, which should allow development of therapy against EHEC. ..
  4. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..We have obtained important information on the functions of endogenous galectin-3 by studying galectin-3-deficient (gal3-/-) mice, and demonstrated that galectin-3 promotes allergic inflammation...
  5. Fu Tong Liu; Fiscal Year: 2014
    ..We also plan to elucidate the cellular basis for galectin-3's regulatory role in a mouse model of atopic dermatitis. ..
  6. Protein inhibitor of galectin-3 to limit fibrosis after myocardial infarction
    MATTHEW LAWRENCE SPRINGER; Fiscal Year: 2013
    ....
  7. Michael Demetriou; Fiscal Year: 2014
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  8. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..To- wards this end, we have identified novel secretory and extracellular matrix proteins (biglycan and galectin 3) and a new GPCR (GPR105) which are differentially highly expressed in CD11c positive macrophages and have ..
  9. Susan L Deutscher; Fiscal Year: 2016
    ..This work is significant and relevant to the VA mission because the peptides discovered here may translate into novel prostate, breast, and ovarian cancer diagnostics and therapeutics for our veterans. ..
  10. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2004
    ..We will examine the roles of the protein kinase C and protein phosphatase families of enzymes in regulating galectin1 cell death. We determine how galectin-3 expression regulates T-cell susceptibility to galectin-1. ..
  11. Mechanism of sepsis development in pulmonary bacterial infection
    Jyotika Sharma; Fiscal Year: 2013
    ....
  12. NORA C HEISTERKAMP; Fiscal Year: 2016
    ..Our preliminary data show that the polyLacNAC-binding lectin Galectin-3 (Gal3) is part of the microenvironment created by stromal cells and identify extracellular Gal3 as a communication ..
  13. Gregory L Stahl; Fiscal Year: 2016
    ..Furthermore, these specific aims may subsequently lead to improved risk stratification, resource utilization, and the development of novel anti-complement therapies to protect against hyperglycemic cardiovascular complications. ..
  14. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..Mice deficient in the innate immune molecule mannose binding lectin are protected from hyperglycemia-induced cardiac fibrogenesis, vascular dysfunction and associated cardiomyopathies. ..
  15. John V Fahy; Fiscal Year: 2016
    ....
  16. Overcoming tumor cell resistance to apoptosis with a natural product, GCS-100
    Linda G Baum; Fiscal Year: 2010
    ....
  17. The Role of Beta-Gal Mediated Interactions in Prostate Cancer Metastasis
    VLADISLAV V GLINSKII; Fiscal Year: 2013
    ..abstract_text> ..
  18. Noorjahan Panjwani; Fiscal Year: 2015
    ..In a recent study, we demonstrated that a carbohydrate- binding protein, galectin-3 (Gal3) is a mediator of the VEGF-mediated angiogenic response...
  19. Lipoic Acid Therapy for Experimental Autoimmune Encephalomyelitis
    DENNIS NEIL BOURDETTE; Fiscal Year: 2013
    ..Current FDA approved therapies for MS cost up to $35,000 a year and are only partially effective. Finding new, cost effective therapies that can slow the progression of MS is of obvious relevance to the health care mission of VHA. ..
  20. Molecular Basis of the Anti-inflammatory Action of MAYP/PSTPIP2
    Violeta Chitu; Fiscal Year: 2012
    ..In addition, they will provide a better understanding of the action of PCH proteins in controlling the inflammatory response. ..
  21. Dean E Brenner; Fiscal Year: 2016
    ..Biosamples will be collected for future biomarker colorectal cancer early detection validation trials and to support EDRN biomarker discovery and prevalidation. ..
  22. Modulation of MUC1 Mucin Trafficking
    Rebecca P Hughey; Fiscal Year: 2010
    ..Our success in these studies will provide novel and fundamental insights into both MUC1-dependent signaling and mislocalization in tumors, which will contribute to a new level of understanding of MUC1 biology in human cancer. ..
  23. SARO ARMENIAN; Fiscal Year: 2014
    ....
  24. JENNIFER EN SIAN HO; Fiscal Year: 2016
    ..This research and training plan will form the basis of a biomarker-guided targeted therapy trial in an at-risk population, to be proposed in an R01 grant application before the end of the K23 award. ..
  25. George J Schwartz; Fiscal Year: 2014
    ..The results of these studies are likely to change our understanding of acid-base physiology and elicit new mechanisms for heretofore unexplained causes of distal renal tubular acidosis. ..
  26. Jianhua Yang; Fiscal Year: 2014
    ..The long-term goal of this proposal is to identify and validate potential druggable enzymatic targets for therapeutic intervention of this devastating disease in children. ..
  27. Methylated Galectin-3 DNA as a Marker for Early Diagnosis of Prostate Cancer
    Hafiz Ahmed; Fiscal Year: 2010
    ..Results from these studies will lead to the development of a non-invasive diagnostic tool not only for early detection, but also for therapeutic guidance and recurrence monitoring of prostate cancer in urine. ..
  28. PABLO ARGUESO; Fiscal Year: 2014
    ..abstract_text> ..
  29. Lei Zheng; Fiscal Year: 2014
    ..This study provides the opportunity to explore the interactions of Tregs and two proteins, Annexin A2 and galectin-3, that have been linked to immune suppression and the progression of PDA. ..
  30. VLADISLAV V GLINSKII; Fiscal Year: 2016
    ....
  31. XIAOSONG JOY JIANG; Fiscal Year: 2016
    ..Galectin-3 (Gal3), a member of 2-galactoside-binding lectin family is known to regulate cell phagocytosis and also is an important ..
  32. Zinaida S Vexler; Fiscal Year: 2016
    ..Understanding the mechanisms regulating repair is an important first step on the way to successful bench-to-bed translation to enhance repair in injured newborn brains. ..
  33. Avraham Raz; Fiscal Year: 2014
    ..abstract_text> ..
  34. Erwin G Van Meir; Fiscal Year: 2016
    ..this proposal we will extend these initial findings by dissecting the underlying mechanisms and determine whether Gal3 has clinical potential...
  35. LEUKOCYTE ADHESION IN ALLERGIC INFLAMMATION
    P Sriramarao; Fiscal Year: 2009
    ..Understanding the role of lectin-carbohydrate interactions in allergic inflammation has the potential to lead to the development of glycan-based therapies (or their mimetics) for the treatment of allergic diseases. ..
  36. 800 MHz Spectrometer for Biomolecular NMR in Missouri
    STEVEN VAN DOREN; Fiscal Year: 2006
    ..The CdtB subunit is sufficient to cause DNA damage and to arrest the cell cycle in mammalian cells. [unreadable] [unreadable]..
  37. ROLE OF TUMOR CELL SURFACE LECTIN IN METASTASIS
    Avraham Raz; Fiscal Year: 2006
    ....
  38. NOVEL FORMULATIONS TO AUGMENT CORNEAL WOUND HEALING
    KATHRYN CRAWFORD; Fiscal Year: 2003
    ..The first stages of drug development will include chemical characterization of the molecules, ophthalmic formulation development, stability analysis, and testing in animal models for corneal wound healing. ..
  39. Tolerogenic Interactions of 4-1BB
    Michael Croft; Fiscal Year: 2010
    ....
  40. INTERACTIONS OF GELATINASES WITH SERUM/MEMBRANE PROTEIN
    Josiah Ochieng; Fiscal Year: 1999
    ..Such studies will provide vital information on the activity of gelatinases on the cell surface as well as in the intracellular spaces. ..
  41. MOLECULAR STUDIES OF FC RECEPTORS FOR IMMUNOGLOBULIN E
    Fu Tong Liu; Fiscal Year: 1993
    ..The long-term goals of this research are: 1) establishment of structure, function and regulation of key components of the IgE system; and 2) development of therapeutic methods for the treatment of human allergic disorders...
  42. Aging and Cancer of the Colon
    STEVEN DUDAS; Fiscal Year: 2004
    ..To our knowledge, this is the first study that proposes to examine these aspects in archival colon cancer specimens in relationship to age. ..
  43. BACTERIAL-BINDING PROTEIN FOR IGE
    Michael Boyle; Fiscal Year: 1999
    ..reagent, a specific antibody to human epsilon heavy chains, with a low-cost high affinity bacterial IgE binding protein. The reagent will improve sensitivity and reduce false negative results for a key screening test to ..
  44. Galectin-3 and Expression of the Asthma Phenotype
    Craig Lilly; Fiscal Year: 2008
    ..These studies will provide new insights into the complex role of lectins and their ligands in allergic diseases. ..
  45. Role of galectin-3 in genital tract immunosuppression
    Alan Diekman; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  46. CARBOHYDRATE BINDING PROTEIN 35
    John Wang; Fiscal Year: 2006
    This project proposes to continue our studies on Carbohydrate Binding Protein 35, which has been renamed galectin-3 (Mr-30,000)...
  47. Notch3 in generation and maintenance of the T lineage.
    Howard T Petrie; Fiscal Year: 2013
    ..stage in N3-deficient mice;assessment of N3 signaling activity in thymus and marrow progenitors, using a N3:Gal3 fusion protein knock-in; and assessment of gene expression in cells that signal through N3, as well as their ..
  48. MOLECULAR BASIS OF INTERCHROMOSOMAL GENE REGULATION
    James E Hopper; Fiscal Year: 2010
    ..cerevisiae. The activities of three proteins, Gal4, Gal80 and Gal3 constitute the primary mechanistic elements of the switch...
  49. MOLECULAR/CELLULAR ACTION OF CRANIN IN NEURAL CELLS
    NEIL SMALHEISER; Fiscal Year: 1993
    ..Information gained via cloning may lead to news means of controlling the expression of cranin in brain, and thus promote optimal axonal growth both in the fetus and in the adult human following insults...
  50. ROLE OF A LAMININ RECEPTOR IN NEUROMUSCULAR DEVELOPMENT
    DENNIS CLEGG; Fiscal Year: 1993
    ..The focus of this grant is to determine the function of aspartactin, a newly discovered muscle surface laminin binding protein whose role in development is unknown...
  51. ACTIVE CONFORMATION OF LAMININ PEPTIDE 11
    Jean Starkey; Fiscal Year: 1999
    The 67 kDa high affinity laminin binding protein (LBP) is a cell surface protein whose expression shows a positive correlation with progression in many solid tumors...
  52. VIRUS BASED BIO-IMAGING & THERAPEUTIC DELIVERY SYSTEMS
    Mark Young; Fiscal Year: 2002
    ..We propose to use site-directed mutagenesis to engineer disulfide linkages and altered pH gating switches at these pores and test for their ability to entrap and release therapeutic materials. ..
  53. Regulation of Bcl2 Function Via Ceramide-Activated PP2A
    Peter Ruvolo; Fiscal Year: 2006
    ..From these results, it is expected that the development of novel anticancer strategies that target mechanisms regulating Bc12 function will occur...
  54. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2008
    ..anti-apoptotic function of galectin-3 and substantiated this function by using cells from galectin-3- deficient (gal3-/-) mice...
  55. Regulation of Skin Wound Epithelialization by Galectin-3
    Fu Tong Liu; Fiscal Year: 2008
    ..Studies of various inflammation models using gal3-/- mice have provided convincing evidence for the role of galectin-3 in promotion of inflammation...
  56. MOLECULAR EVENTS IN UROGENITAL DEVELOPMENT
    Qais Al Awqati; Fiscal Year: 2008
    ..Hence, studies of the early stages of kidney development, the stage at which the number ofnephrons is determined are likely to have wide clinical implications. ..
  57. Immunological Basis of Anti-IgE Therapy
    Fu Tong Liu; Fiscal Year: 2003
    ..We also hope that the studies will lead to a better understanding of the mechanisms of allergic diseases. ..
  58. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2005
    ..a role for galectin-3 in promotion of inflammatory responses and recent studies with galectin-3-deficient (gal3-/-) mice lend strong support to this...
  59. Validation of Galectin-3 as a Target in Cancer Therapy
    Fu Tong Liu; Fiscal Year: 2003
    ..The effect of these inhibitors on adhesion of cancer cells to extracellular matrix proteins and invasive properties of cancer cells will be evaluated. ..
  60. Bone-Homing Molecules on Human Prostate Tumor Cells
    CHARLES DIMITROFF; Fiscal Year: 2004
    ..Molecular analysis of identified E-selectin ligand(s) will provide rationale for the development of anti-metastatic therapeutics against these new targets. ..
  61. Molecular Mechanisms of Cardiac Arrhythmias
    Qing Wang; Fiscal Year: 2005
    ..These studies may provide a new framework for the rational design of therapeutic agents. ..
  62. Pilot Testing of VEGF/PDGF inhibitors for chemoprevention of bone metastasis
    Hyeong Reh Kim; Fiscal Year: 2007
    ..This information will be useful in designing more rational therapeutic interventions aimed at modulating the PDGF/VEGF signaling pathways. [unreadable] [unreadable] [unreadable]..
  63. Enhancing axon regeneration by multi-inhibitor blocking
    RONALD SCHNAAR; Fiscal Year: 2005
    ..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..
  64. TRH Production and Regulation by Human Melanoma
    Julie Ellerhorst; Fiscal Year: 2006
    ..In Specific Aim #2, cell lines will be used for in vitro studies to determine if one or more of the mechanisms of hypothalamic TRH regulation are relevant to the control of TRH production by melanoma cells. [unreadable] [unreadable]..
  65. 67 KD LAMININ BINDING PROTEIN ON HUMAN T LYMPHOCYTES
    Stephen Canfield; Fiscal Year: 2003
    ..A search for genes expressed in activated T cells revealed that the non-integrin, 67 kD laminin binding protein (p67 LBP) is expressed on the surface of a subset (10-15 percent) of activated peripheral blood T cells...
  66. Inflammation & Prognosis in Decompensated Heart Failure
    GARY FELKER; Fiscal Year: 2008
    ..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..
  67. Mechanism of Circadian Susceptibility to Pesticides
    LOUISA HOOVEN; Fiscal Year: 2008
    ..Humans are inevitably exposed to pyrethroids and other pesticides, and this interdisciplinary investigation is likely to lead to novel strategies protective of human health. [unreadable] [unreadable] [unreadable]..
  68. Human Sertoli Cell Model for Study of Male Reproductive Function and Toxicity
    Constance John; Fiscal Year: 2007
    ..There is a great need for more accurate, less costly and time- consuming methods of assessing effects on reproductive function and toxicity. [unreadable] [unreadable] [unreadable]..
  69. MINERALIZATION OF PRIMARY BONE
    JEFFREY GORSKI; Fiscal Year: 2008
    ..Results of this work should better define the differences between primariy and lamellar bone, as well as aid in the diagnosis and treatment of osteoporosis and atherosclerosis. ..
  70. Role of Na, K-ATPase beta isoforms in pump sorting and epithelial integrity
    Olga Vagin; Fiscal Year: 2010
    ....
  71. Molecular Determinants of Coronary Artery Disease
    Qing Wang; Fiscal Year: 2004
    ..The accomplishment of research objectives in this proposal has the potential to have a substantial impact on the understanding of the molecular mechanism of CAD and MI, thereby facilitating better prevention, diagnosis and therapy. ..
  72. MUCIN GLYCOPROTEINS IN COLON CANCER METASTASIS
    Robert S Bresalier; Fiscal Year: 2010
    ..3) Determine the functional mechanism(s) by which galectin-3 modifies expression of MUC2 in colon cancer cells. ..
  73. MENTORED ORIENTED RESEARCH CAREER DEVELOPMENT AWARD
    Jared Gollob; Fiscal Year: 2004
    ....
  74. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  75. Autoimmune Mechanisms in the Response to Renal Cancer
    Julie Ellerhorst; Fiscal Year: 2006
    ..These data will be clinically useful in predicting outcomes of RCC patients, as well as in the understanding of basic mechanisms of host-derived tumor control. ..