Genomes and Genes
Gene Symbol: GABRA1
Description: gamma-aminobutyric acid type A receptor alpha1 subunit
Alias: ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, GABA(A) receptor, alpha 1, gamma-aminobutyric acid (GABA) A receptor, alpha 1
Publications165 found, 100 shown here
- Isolation and characterization of the promoter of the human GABAA receptor alpha 1 subunit geneI Kang
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts 02111
J Neurochem 62:1643-6. 1994..Transcriptional activity of this promoter construct was strongly repressed by chronic administration of lorazepam...
- GABAA alpha-1 subunit gene not associated with depressive symptomatology in mood disordersA Serretti
Department of Neuroscience, School of Medicine, University of Milano, Italy
Psychiatr Genet 8:251-4. 1998..the possibility that the gene for the gamma-aminobutyric acid type A (GABAA) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects...
- Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogueDavid C Chiara
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, United States
Biochemistry 51:836-47. 2012..Etomidate-inhibitable photolabeling of β3Met-227 in βM1 by [³H]TDBzl-etomidate and [³H]azietomidate also provides evidence of a homologous etomidate binding site at the β3-β3 subunit interface in the α1β3 GABA(A)R...
- Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits are important for assemblyI Sarto
Division of Biochemistry and Molecular Biology, Brain Research Institute, University of Vienna, Spitalgasse 4, Austria
Neuropharmacology 43:482-91. 2002..Finally, it was demonstrated that the sequences investigated cause a selective assembly with certain subunits only and thus influence subunit arrangement within GABA(A) receptors...
- Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disordersYasue Horiuchi
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Biol Psychiatry 55:40-5. 2004..The GABRA1 gene encodes one of the subunits of GABA-A receptor and is located on human chromosome 5q34-q35, which is a region ..
- Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disordersA Serretti
Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy
Psychiatry Res 87:7-19. 1999..receptor D2 (DRD2), D4 exon 3 (DRD4), and gamma-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) gene variants on the efficacy of lithium prophylaxis in mood disorders...
- Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5Kuo Chen Chou
Tianjin Institute of Bioinformatics and Drug Discovery, Tianjin 300074, China
Biochem Biophys Res Commun 316:636-42. 2004..The present models might be also useful in understanding the basic mechanism of operation of the GABA-A receptors, stimulating novel strategies for developing more specific drugs and better treatments...
- Mutations in GABAA receptor subunits associated with genetic epilepsiesRobert L Macdonald
Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Avenue, Nashville, TN 37232 8552, USA
J Physiol 588:1861-9. 2010Mutations in inhibitory GABAA receptor subunit genes (GABRA1, GABRB3, GABRG2 and GABRD) have been associated with genetic epilepsy syndromes including childhood absence epilepsy (CAE), juvenile myoclonic epilepsy (JME), pure febrile ..
- Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autismD Q Ma
Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 77:377-88. 2005..were screened in the following genes: GABRG1, GABRA2, GABRA4, and GABRB1 on chromosome 4p12; GABRB2, GABRA6, GABRA1, GABRG2, and GABRP on 5q34-q35.1; GABRR1 and GABRR2 on 6q15; and GABRA5, GABRB3, and GABRG3 on 15q12...
- Whole-genome association studies of alcoholism with loci linked to schizophrenia susceptibilityJunghyun Namkung
Bioinformatics Program, Seoul National University, Seoul 151 747, South Korea
BMC Genet 6:S9. 2005..For the genetic study of complex diseases, association analysis has been recommended because of its higher power than that of the linkage analysis for detecting genes with modest effects on disease...
- Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor β(2) subunitF W Pun
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Mol Psychiatry 16:557-68. 2011..of allelic expression in heterozygotes of SNP rs2229944 (C/T) in GABRB2 or rs2290732 (G/A) in the neighboring GABRA1 was compatible with imprinting effects on gene expression...
- Genetics of bipolar disorderTadafumi Kato
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
Drugs Today (Barc) 41:335-44. 2005..Among recently reported candidate genes, BDNF, G72, AKT1, GRIN2A, XBP1, GRK3, HTR4, IMPA2 and GABRA1 may have some importance...
- Changes in neuronal activity and gene expression in guinea-pig auditory brainstem after unilateral partial hearing lossS Dong
Physiology, School of Biomedical, Biomolecular and Chemical Sciences, M311, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, WA, Australia
Neuroscience 159:1164-74. 2009..Expression of glutamate decarboxylase 1 (GAD1), GABA-A receptor subunit alpha-1 (GABRA1), and potassium channel subfamily K member 15 (KCNK15) was decreased ipsilaterally in the cochlear nucleus and ..
- Advances on the genetics of Mendelian idiopathic epilepsiesStephanie Baulac
CRICM UPMC Paris6 UMR S975 Inserm U975 CNRS UMR 7225, F 75013, Bâtiment Pharmacie, Hôpital de Pitié Salpêtrière, 47 Boulevard de l Hopital, 75013 Paris, France
Clin Lab Med 30:911-29. 2010..dominant transmission have revealed 11 genes (KCNQ2, KCNQ3, CHRNA4, CHRNA2, CHRNB2, SCN1B, SCN1A, SCN2A, GABRG2, GABRA1, and LGI1) and numerous loci for febrile seizures and epilepsies...
- Whole-genome scan identifies quantitative trait loci for chronic pastern dermatitis in German draft horsesE Henrike Mittmann
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bunteweg 17p, 30559, Hannover, Germany
Mamm Genome 21:95-103. 2010..For the Rhenish German and Schleswig draft horses, additional QTL on ECA4 and 10 and for the South German draft horses an additional QTL on ECA7 were found...
- Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunitsP R Schofield
Zentrum fur Molekulare Biologie, University of Heidelberg, FRG
FEBS Lett 244:361-4. 1989..The cloned human GABAA receptor subunits induce the formation of GABA-gated chloride channels when expressed in mammalian cells...
- GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1F K Bedford
Medical Research Council Laboratory of Molecular Cell Biology and Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Nat Neurosci 4:908-16. 2001..Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes...
- Association analysis of chromosome 5 GABAA receptor cluster in Japanese schizophrenia patientsMasashi Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Biol Psychiatry 58:440-5. 2005..A GABA(A) receptor gene cluster on 5q31-35 (beta2 [GABRB2], alpha6 [GABRA6], alpha1 [GABRA1], and gamma2 [GABRG2] subunit genes) is one of the most attractive candidate regions for schizophrenia ..
- No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophreniaRami Abou Jamra
Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
Psychiatr Genet 17:43-5. 2007..abundant gamma-amino-n-butyric acid type A receptor subtype in mammalian brains and the corresponding genes, the GABRA1, GABRB2, and GABRG2 genes, are located in chromosomal region 5q34 that several genome wide scans have implicated ..
- On the molecular mechanism of water reorientationDamien Laage
Chemistry Department, Ecole Normale Superieure, 24 rue Lhomond 75005 Paris, France
J Phys Chem B 112:14230-42. 2008..water reorientation based on molecular dynamics simulations and the analytic framework of the extended jump model (EJM)...
- A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophreniaShashwath A Meda
Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
Neuroimage 53:1007-15. 2010....
- Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorderElaine K Green
Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 153:1347-9. 2010..Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052)...
- A state-dependent salt-bridge interaction exists across the β/α intersubunit interface of the GABAA receptorKurt T Laha
Department of Biological Sciences, Marquette University, Milwaukee, WI 53201 1881, USA
Mol Pharmacol 79:662-71. 2011..These data suggest that β(2)Asp163 and α(1)Arg120 form a state-dependent salt bridge, interacting when GABA is bound to the receptor but not when the receptor is in the unbound state...
- Identification of GABRA1 and LAMA2 as new DNA methylation markers in colorectal cancerSunwoo Lee
Genomictree Inc, Daejeon, Republic of Korea
Int J Oncol 40:889-98. 2012..the two gene-sets, we subsequently selected, through stepwise subtraction processes, two novel genes, GABRA1 and LAMA2, as methylation targets in colorectal cancer...
- Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptomsKe Sheng Wang
Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614 1700, USA
J Neural Transm (Vienna) 119:425-33. 2012..0013 and 0.0162, respectively). In addition, several SNPs in GABRA1, GABRG1, and GABRG3 were associated with AWS (p < 10(-2)) in the COGA sample...
- The altered expression of α1 and β3 subunits of the gamma-aminobutyric acid A receptor is related to the hepatitis C virus infectionM Sidorkiewicz
Department of Medical Biochemistry, Medical University of Łódź, Łódź, Poland
Eur J Clin Microbiol Infect Dis 31:1537-42. 2012..The modulation of α1 and β3 GABA A receptors subunits expression in PBMCs may be associated with ongoing or past HCV infection...
- miR-155 is up-regulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptorsPietro I D'Urso
Department of Biological and Environmental Sciences and Technologies, DiSTeBA, University of Salento, I 73100 Lecce, Italy
Int J Oncol 41:228-34. 2012..We hypothesised that γ-aminobutyric acid A receptor 1 (GABRA1) is a miR-155 target, and studied the correlation between miR-155 up-regulation and the GABRA1 protein in cultured ..
- A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sitesRikke Bergmann
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 8:e52323. 2013..We present a binding mode of DZP in which the pending phenyl moiety of DZP is buried in the binding pocket and thus shielded from solvent exposure. Our full length GABA(A) receptor is made available as Model S1...
- Mutant GABA(A) receptor subunits in genetic (idiopathic) epilepsyShinichi Hirose
Department of Pediatrics, School of Medicine, Fukuoka University, Fukuoka, Japan Central Research Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka, Japan Electronic address
Prog Brain Res 213:55-85. 2014..In fact, mutations or genetic variations of the genes encoding the α1, α6, β2, β3, γ2, or δ subunits (GABRA1, GABRA6, GABRB2, GABRB3, GABRG2, and GABRD, respectively) have been associated with human epilepsy, both with and ..
- Adolescent-onset GABAA α1 silencing regulates reward-related decision makingLaura M Butkovich
Graduate Program in Neuroscience, Emory University, Atlanta, GA, USA
Eur J Neurosci 42:2114-21. 2015..selectively in the medial prefrontal cortex (prelimbic subregion) of mice using viral-mediated gene silencing of Gabra1. Adolescent-onset Gabra1 knockdown delayed the acquisition of a cocaine-reinforced instrumental response but ..
- Gene expression profiling analysis of MENX-associated rat pituitary adenomas contributes to understand molecular mechanisms of human pituitary adenomasHongzhi Zhang
Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P R China
Oncol Lett 11:125-133. 2016..These DEGs interacted with each other. The downregulated DEGs (e.g., GABRA1, GABRA4 and GABRB1) also interacted with each other, and were relevant to neuroactive ligand-..
- c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expressionR Wang
Department of Biotechnology, School of Life Science, Jilin Normal University, Siping, China
Acta Physiol (Oxf) 219:494-509. 2017..The aim of this study was to investigate the role of c-Jun N-terminal kinase (JNK) in expressional regulation of gamma-aminobutyric acid signalling in PVN in CHF rats...
- Phenotypic spectrum of GABRA1: From generalized epilepsies to severe epileptic encephalopathiesKatrine Johannesen
Authors affiliations are listed at the end of the article
Neurology 87:1140-51. 2016To delineate phenotypic heterogeneity, we describe the clinical features of a cohort of patients with GABRA1 gene mutations.
- Do the exome: A case of Williams-Beuren syndrome with severe epilepsy due to a truncating de novo variant in GABRA1Bernt Popp
Institute of Human Genetics, Friedrich Alexander Universität Erlangen Nürnberg FAU, Erlangen, Germany Electronic address
Eur J Med Genet 59:549-53. 2016..Using trio-exome sequencing, we identified a de novo truncating variant c.1200del, p (Lys401Serfs*25) in GABRA1 as the likely cause of the early onset epilepsy...
- Gene Panel Testing in Epileptic Encephalopathies and Familial EpilepsiesRikke S Møller
Danish Epilepsy Centre, University of Southern Denmark, Denmark Institute for Regional Health Services, University of Southern Denmark, Denmark
Mol Syndromol 7:210-219. 2016..The variants were found in 19 different genes including SCN1A, STXBP1, CDKL5, SCN2A, SCN8A, GABRA1, KCNA2, and STX1B...
- Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in ChinaWeixing Feng
Department of Neurology, Beijing Children s Hospital affiliated to Capital Medical University Department of Pediatrics, Beijing Tiantan Hospital, Capital Medical University Pharmacy, Beijing Tiantan Hospital, Capital Medical University and Department of Clinical Pharmacology, College of Pharmaceutical Sciences, Capital Medical, Beijing, China
Ther Drug Monit 38:738-743. 2016..This study aimed to evaluate the effects of various genetic variations on normalized plasma concentration of VPA (NCVPA) and the treatment response in Chinese children with epilepsy administered with VPA...
- High-resolution physical mapping of human 5q31-q33 using three methods: radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresisJ A Warrington
Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717
Genomics 24:395-8. 1994..the predicted order of the 12 loci is cen-ADRB2-PDEA-CSF1R-RPS14-ANX6-SPARC++ +-GLRA1-GLUR1-ADRA1B-IL12- GABRG2-GABRA1-tel...
- Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprintingJiuzhou Song
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202 5122, USA
Am J Med Genet B Neuropsychiatr Genet 117:39-45. 2003..03). Genes encoding GABRA1 and GABRA6, on chromosome 5, did not provide evidence for association with alcoholism...
- Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunitsHenry J Waldvogel
Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
J Comp Neurol 470:339-56. 2004..GABA also acts through GABA(A) receptors containing the alpha(1) subunit on specific striatal GABAergic interneurons and on output neurons of the globus pallidus and substantia nigra pars reticulata...
- No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sampleDanielle M Dick
Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut St, Indianapolis, IN 46202 525, USA
Am J Med Genet B Neuropsychiatr Genet 132:24-8. 2005..Chromosome 5 contains a cluster of GABA(A) receptor genes, GABRA1, GABRA6, GABRB2, and GABRG2, which have been among the most extensively studied in relation to alcohol use...
- [Advances in the studies on the molecular and genetic aspects of epilepsy]Xu Wang
Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan 430074, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:388-93. 2005..SCN1A, SCN2A, and SCN1B, chloride channels CLCN2, and ligand-gated ion channels CHRNA4, CHRNB2, GABRG2, and GABRA1. Interestingly, non-ion channel genes have also been identified as epilepsy genes, and these genes include G-..
- Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptorsAmulya Nidhi Shrivastava
Department of Biochemistry and Molecular Biology, Center for Brain Research, Medical University of Vienna, Vienna 1090, Austria
J Biol Chem 286:14455-68. 2011..We further conclude that blocking the excitatory activity of excessively released ATP under diseased state by P2XR antagonists could simultaneously enhance synaptic inhibition mediated by GABA(A)Rs...
- Selective pyramidal cell reduction of GABA(A) receptor α1 subunit messenger RNA expression in schizophreniaJill R Glausier
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Neuropsychopharmacology 36:2103-10. 2011..The cell type specificity of these findings may reflect a compensatory response to enhance layer 3 pyramidal cell activity in the face of the diminished excitatory drive associated with the lower dendritic spine density on these neurons...
- Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsyPamela Lachance-Touchette
Centre for Excellence in Neuromics of University of Montreal, CHUM Research Center, 1560 Sherbrooke Est, Montreal, QC, Canada H2L 4M1
Eur J Neurosci 34:237-49. 2011..of additional mutations in the GABA(A) receptor by direct sequencing of the complete open reading frame of the GABRA1 and GABRG2 genes from a cohort of French Canadian families with idiopathic generalized epilepsy (IGE)...
- Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET imagesJames F M Myers
Psychopharmacology Unit, University of Bristol, Bristol, UK
J Cereb Blood Flow Metab 32:731-44. 2012..The proposed method for [(11)C]Ro15-4513 analysis may allow more accurate selective binding assays and estimation of drug occupancy for other nonselective ligands...
- [Relationship between gene polymorphism of GABAA receptors gene and childhood autism]Guo Bin Lu
Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China
Zhonghua Yu Fang Yi Xue Za Zhi 46:460-4. 2012..To explore the relationship between gene polymorphism of GABAA receptors and childhood autism by detecting rs140682, rs2081648 and rs140679 site of single nucleotide polymorphism (SNP) in GABAA receptors gene...
- Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2Yuhong Wang
Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA 23298, USA
J Gen Physiol 140:653-69. 2012..plays a key role in modulating KCNQ1 pore conductance and gating kinetics, and the extracellular juxtamembrane (EJM) region plays a modulatory role by interacting with the extracellular surface of KCNQ1...
- Evidence for interaction between markers in GABA(A) receptor subunit genes in an Argentinean autism spectrum disorder populationCarla V Sesarini
Instituto de Ciencias Básicas y Medicina Experimental ICBME, CABA, Argentina
Autism Res 7:162-6. 2014..Single-nucleotide polymorphisms (SNP) located within the GABA receptor (GABAR) subunit genes GABRA1, GABRG2, GABRB3, and GABRD were screened...
- GABRA1 and STXBP1: novel genetic causes of Dravet syndromeGemma L Carvill
From the Division of Genetic Medicine, Department of Pediatrics G L C, C H, J C, E G, H C M, and the Department of Genome Sciences J S, University of Washington, Seattle Neurogenetics Group S W, Department of Molecular Genetics, VIB, Antwerp Laboratory of Neurogenetics S W, A s, P D J, Institute Born Bunge, University of Antwerp, Belgium Epilepsy Centre Kempenhaeghe S W, Oosterhout, the Netherlands Epilepsy Research Centre J M M, S F B, I E S, Department of Medicine, University of Melbourne, Austin Health, Australia Department of Neuropediatrics C H, H M, S V S, I H, University Medical Center, Schleswig Holstein, Christian Albrechts University, Kiel, Germany Danish Epilepsy Centre R S M, H H, M N, Polar Desert Research Center
Neurology 82:1245-53. 2014..To determine the genes underlying Dravet syndrome in patients who do not have an SCN1A mutation on routine testing...
- A novel variant in GABRB2 associated with intellectual disability and epilepsySiddharth Srivastava
Hugo W Moser Research Institute at Kennedy Krieger Institute, Baltimore, Maryland Departments of Neurology and Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland
Am J Med Genet A 164:2914-21. 2014..Mutations in genes encoding various subunits of this receptor (GABRA1, GABRA2, GABRA4, GABRA5, GABRA6, GABRB1, GABRB3, GABRG1, GABRG2, GABRG3, and GABRD) are implicated in a number of ..
- Animal models of absence epilepsies: what do they model and do sex and sex hormones matter?Gilles van Luijtelaar
Donders Centre of Cognition, Radboud University Nijmegen, Nijmegen, The Netherlands Electronic address
Neurobiol Dis 72:167-79. 2014..females show a higher incidence than prepubertal males), BN model (also with a higher prevalence in males) and the Gabra1 deletion mouse in the C57BL/6J strain offer unique possibilities for the investigation of the mechanisms involved ..
- Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastomaChristopher S Hackett
Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
Cell Rep 9:1034-46. 2014..These results suggest that ARG1 and GABA influence both neural development and neuroblastoma and that benzodiazepines in clinical use may have potential applications for neuroblastoma therapy...
- Deletion of the Wolfram syndrome-related gene Wfs1 results in increased sensitivity to ethanol in female miceSirli Raud
Department of Physiology, Institute of Bio and Translational Medicine, University of Tartu, Tartu, Estonia Centre for Excellence in Translational Medicine, University of Tartu, Estonia Electronic address
Neuropharmacology 95:59-67. 2015..No changes were detected in Gabra1 and Gabra3 mRNA following ethanol treatment...
- Insights into Human Astrocyte Response to H5N1 Infection by Microarray AnalysisXian Lin
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
Viruses 7:2618-40. 2015..expressions related to the neuroactive ligand-receptor interaction pathway at 24 hpi, such as MC2R, CHRNG, P2RY13, GABRA1, and HRH2, which participant in synaptic transmission and may take part in CNS disorders induced by H5N1 infection...
- Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific mannerLik Wei Wong
Health Innovation Research Institute, School of Medical Sciences, RMIT University, Melbourne, Vic, Australia
J Neurochem 134:819-32. 2015..Indeed, robust receptor levels remain when the extension and α-helix are removed in β or γ subunits...
- Genetic Causes of Generalized EpilepsiesIngo Helbig
Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
Semin Neurol 35:288-92. 2015..GEFS+) and GGE through studies of large families, discovering causative mutations in SCN1A, SCN1B, GABRG2, and GABRA1. Subsequently, recurrent microdeletions at 15q13.3, 16p13.11, and 15q11...
- Subregional Expression of Hippocampal Glutamatergic and GABAergic Genes in F344 Rats with Social Isolation after WeaningHisaya Iwata
Laboratory of Animal Genetics and Physiology, Department of Animal Science, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan
Comp Med 66:4-9. 2016..In contrast, pwSI tended to decrease the expression of GABAA receptor subunit genes, and Gabra1, Gabra2, Gabra4, Gabra5, Gabrb2, Gabrg1, and Gabrg2 were all significantly decreased in expression compared with ..
- De novo GABRA1 mutations in Ohtahara and West syndromesHirofumi Kodera
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Epilepsia 57:566-73. 2016b>GABRA1 mutations have been identified in patients with familial juvenile myoclonic epilepsy, sporadic childhood absence epilepsy, and idiopathic familial generalized epilepsy...
- Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized RatsMiklós Sárvári
Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences Budapest, Hungary
Front Cell Neurosci 10:149. 2016..Crhr2, Oprm1, Gnrhr, Galr2, Sstr1, Sstr3), neurotransmitter receptors (Htr1a, Htr2c, Htr2a, Gria2, Gria3, Grm5, Gabra1, Chrm5, Adrb1), and vesicular neurotransmitter transporters (Slc32a1, Slc17a7)...
- Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsyLi Ding
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, U S A
Epilepsia 57:1568-1580. 2016..Recently, we reported that mice with a juvenile myoclonic epilepsy mutation (Gabra1[A322D]) exhibited both absence and myoclonic generalized seizures...
- Understanding Genotypes and Phenotypes in Epileptic EncephalopathiesIngo Helbig
Division of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA Division of Department of Neuropediatrics, Christian Albrechts University of Kiel and University Medical Center Schleswig Holstein UKSH, Kiel, Germany
Mol Syndromol 7:172-181. 2016..phenotypes can be seen in patients with mutations in PCDH19, CHD2, SCN8A, or in rare cases GABRA1 and STXBP1...
- Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophreniaShabeesh Balan
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Schizophr Res . 2017..Two SNPs located in the GABRA1 gene, rs4263535 (Pallele=0.002; uncorrected) and rs1157122 (Pallele=0...
- The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsyH L Grabenstatter
Department of Pediatrics, Division of Neurology and Translational Epilepsy Research Program, University of Colorado School of Medicine, Aurora, CO, USA
Neurobiol Dis 62:73-85. 2014..Protein and/or mRNA levels for pSTAT3, and STAT3-regulated genes including: ICER, Gabra1, c-myc, mcl-1, cyclin D1, and bcl-xl were evaluated in WP1066 and vehicle-treated rats during stages of ..
- Evidence of association between gamma-aminobutyric acid type A receptor genes located on 5q34 and female patients with mood disordersKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Neurosci Lett 349:9-12. 2003..In the present study, we examined GABA(A) receptor alpha1 (GABRA1), alpha6 (GABRA6) and gamma2 (GABRG2) subunit genes on 5q34...
- Regulation of the expression of GABAA receptor subunits by an antiepileptic drug QYSXianchun Li
Key Lab of Brain Functional Genomics, MOE and STCSM, Shanghai Institute of Brain Functional Genomics, East China Normal University, Shanghai
Neurosci Lett 392:145-9. 2006..The results showed that treatment of QYS significantly increased the expressions of Gabra1, Gabra2 and Gabr4 and decreased the expression of Gabrg2 in inferior colliculus...
- Seizures of idiopathic generalized epilepsiesReyna M Duron
California Comprehensive Epilepsy Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Epilepsia 46:34-47. 2005..Mutations in GABRA1, GABRG2, and GABRB3 are associated with absence seizures, while mutations in CLCN2 and myoclonin/EFHC1 ..
- A high-resolution comparative radiation hybrid map of equine chromosome 4q12-q22C Dierks
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Foundation, Bunteweg 17p, 30559 Hannover, Germany
Anim Genet 37:513-7. 2006In this study, we present a comprehensive 5000-rad radiation hybrid map of a 40-cM region on equine chromosome 4 (ECA4) that contains quantitative trait loci for equine osteochondrosis...
- Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticusYogendraSinh H Raol
Division of Neurology, Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, Philapelphia, Pennsylvania, USA
Epilepsia 47:1665-73. 2006..and adult rats suggest that status epilepticus (SE) induces changes in the alpha1 subunit of the GABA(A) receptor (GABRA1) in dentate granule neurons (DGNs) that are age dependent and vary inversely with the likelihood of epilepsy ..
- Chorein deficiency leads to upregulation of gephyrin and GABA(A) receptorYutaka Kurano
Department of Psychiatry, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8520, Japan
Biochem Biophys Res Commun 351:438-42. 2006..protein, we compared the protein-level expression and localization of gephyrin and the GABA(A) receptor alpha1 (GABRA1) and gamma2 (GABRG2) subunits...
- Adult-onset autosomal dominant myoclonic epilepsy: report of a family with an overlooked epileptic syndromeYue Loong Hsin
Department of Neurology, Buddhist Tzu Chi General Hospital, and Institute of Medical Sciences, Buddhist Tzu Chi University, Hualien, Taiwan
Seizure 16:160-5. 2007..Myoclonic epilepsy is a common epileptic syndrome with high genetic contribution. We described a pedigree in which 10 individuals presented with a non-progressive, adult-onset myoclonic epilepsy...
- Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophreniaMonica Beneyto
Department of Psychiatry, University of Pittsburgh, W1656 Biomedical Science Tower, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Cereb Cortex 21:999-1011. 2011....
- Amygdala gene expression of NMDA and GABA(A) receptors in patients with mesial temporal lobe epilepsyJosé Carlos de Moura
Department of Surgery and Anatomy, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo USP, SP, Brazil
Hippocampus 22:92-7. 2012..Our results suggest that the NR1 subunit of NMDA receptors is involved in the amygdala hyperexcitability in some of the patients with TLE...
- Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient miceJürgen Innos
Department of Physiology, University of Tartu, Tartu, Estonia
Behav Brain Res 217:21-31. 2011..possible explanation for the anxiolytic-like effect of the deletion of the Lsamp gene is a shift in balance in the Gabra1 and Gabra2 genes in the temporal lobe in favor of the Gabra2 transcript, encoding α2 subunit of GABA(A) receptors ..
- Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor functionKate K O'Toole
Department of Anesthesiology, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 286:37990-9. 2011..Within this subdomain, the α1(K378E) mutation induced a significant reduction in single channel conductance, consistent with our hypothesis that the GABA(A)R α1 ILD contributes directly to the permeation pathway...
- Increased DNA methylation of neuropsychiatric genes occurs in borderline personality disorderGerhard Dammann
Psychiatric Hospital, Muensterlingen, Switzerland
Epigenetics 6:1454-62. 2011..In our study we analyzed DNA methylation patterns of 14 neuropsychiatric genes (COMT, DAT1, GABRA1, GNB3, GRIN2B, HTR1B, HTR2A, 5-HTT, MAOA, MAOB, NOS1, NR3C1, TPH1 and TH)...
- [The expression of GABA(A) receptor alpha1 and GABA(B) receptor 1 in medulla oblongata solitary nucleus and ambiguous nucleus in the cases of tramadol intoxication]Shu Zhang
Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China
Fa Yi Xue Za Zhi 27:401-4. 2011..To observe the expression of GABA(A) receptor alpha1 (GABA(A)alpha1) and GABA(B) receptor 1 (GABA(B)1) in human medulla oblongata solitary nucleus and ambiguous nucleus due to tramadol-induced death...
- Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulationMegan K Mulligan
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
PLoS ONE 7:e34586. 2012..Expression of Gabra1, Gabra2, Gabrb2, Gabrb3, and Gabrg2 is highly variable and heritable among the large cohort of BXD strains derived ..
- Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticityLaurence Desrues
Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, Astrocyte and Vascular Niche, University of Rouen, Mont Saint Aignan, France
PLoS ONE 7:e36319. 2012..This UII-induced disappearance of the repressor activity of GABA(A)R, may play a key role in the initiation of astrocyte proliferation...
- Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cordZhen Guo
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Neurosci 32:8509-20. 2012..We found that receptor genes Gabra1, Gabra5, Gabrb2, Gria3, Grin3a, Grin3b, Galr1, and Npy1r were preferentially expressed in Tlx3-expressing ..
- Potential Impact of miR-137 and Its Targets in SchizophreniaCarrie Wright
Department of Neurosciences, Health Sciences Center, University of New Mexico Albuquerque, NM, USA
Front Genet 4:58. 2013..miR-137 targets, there are other schizophrenia-associated genes that may be targets of miR-137, including ERBB4, GABRA1, GRIN2A, GRM5, GSK3B, NRG2, and HTR2C...
- γ-Amino-butyric acid (GABA) receptor subunit and transporter expression in the gonad and liver of the fathead minnow (Pimephales promelas)Katie Biggs
Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, Canada
Comp Biochem Physiol A Mol Integr Physiol 166:119-27. 2013..gad65, gad67, vesicular GABA transporter (vgat) and GABA transporter 1 (gat1), and select GABAA receptor subunits (gabra1, gabra5, gabrb1, gabrb2, gabrg1, gabrg2)...
- Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptorDavid C Chiara
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 288:19343-57. 2013..We hypothesize that binding at any of these homologous intersubunit sites is sufficient for anesthetic action and that this explains to some degree the puzzling structural heterogeneity of anesthetics. ..
- Gene-wide tagging study of the effects of common genetic polymorphisms in the α subunits of the GABA(A) receptor on epilepsy treatment responseChin Chuan Hung
Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan and Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan
Pharmacogenomics 14:1849-56. 2013..We aimed to identify the effect of SNPs in the α-subunits of GABAA receptors on epilepsy treatment outcomes by using a gene-wide tagging method...
- Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsiesOzlem Yalcin
Department of Molecular Biology and Genetics, T C Istanbul Arel University, Tepekent Buyukcekmece, Istanbul, Turkey
Seizure 21:79-86. 2012..mutations and susceptibility alleles determined in the genes that code for the subunits of GABA receptors (GABRG2, GABRA1, GABRB3, GABRA5, GABA(B1) and GABA(B2)), calcium channels (CACNA1A, CACNA1G, CACNA1H, CACNA1I, CACNAB4, CACNAG2 ..
- Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5qS G Ryan
Department of Pediatrics, University of Texas Health Science Center, San Antonio 78284
Am J Hum Genet 51:1334-43. 1992..RH mapping eliminated the candidate genes GABRA1 and GABRG2, which encode GABA-A receptor components, by showing that they are telomeric to the target region.
- Radiation hybrid map of 13 loci on the long arm of chromosome 5J A Warrington
Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717
Genomics 11:701-8. 1991..encoding growth factors, growth factor receptors, or hormone receptors (IL3, IL4, IL5, CSF1R, FGFA, ADRB2, GRL, GABRA1, and DRD1) as well as four other loci (FER, SPARC, RPS14, and CD14) to generate a radiation hybrid map of the area ..
- Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysisA A Hicks
MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, United Kingdom
Genomics 20:285-8. 1994..87 at a theta of 0.069 (males) and 0.100 (females). These results reveal the clustering of GABRA6, GABRA1, and the GABAA receptor gamma 2-subunit gene (GABRG2) on distal chromosome 5q.
- Assignment of genes encoding GABAA receptor subunits alpha 1, alpha 6, beta 2, and gamma 2 to a YAC contig of 5q33M Kostrzewa
Institut fur Humangenetik, Justus Liebig Universitat Giessen, Germany
Eur J Hum Genet 4:199-204. 1996A gene cluster consisting of the four gamma-aminobutyric acidA (GABAA) receptor subunit genes GABRA1, GABRA6, GABRAB2, and GABRG2 was assigned to a yeast artificial chromosome (YAC) contig of 5q33...
- A primary male autosomal linkage map of the horse genomeG Lindgren
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S 751 24 Uppsala, Sweden
Genome Res 8:951-66. 1998..into 25 linkage groups, 22 of which could be assigned physically to 18 different chromosomes (ECA1, ECA2, ECA3, ECA4, ECA5, ECA6, ECA7, ECA9, ECA10, ECA11, ECA13, ECA15, ECA16, ECA18, ECA19, ECA21, ECA22, and ECA30)...
- No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychosesA Serretti
Department of Neuroscience, Istituto Scientifico H San Raffaele, University of Milan School of Medicine, Italy
Am J Med Genet 88:44-9. 1999..cohort of subjects to evaluate the gene for the gamma-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1)...
- Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsyPatrick Cossette
Centre for Research in Neuroscience, McGill University Health Center Research Institute and McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
Nat Genet 31:184-9. 2002..We report that an Ala322Asp mutation in GABRA1, encoding the alpha1 subunit of the gamma-aminobutyric acid receptor subtype A (GABA(A)), is found in affected ..
- Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumptionSandeep Kumar
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
J Neurochem 82:110-7. 2002..These results suggest that PKCgamma may be involved in GABA(A) receptor adaptations following chronic ethanol consumption...
- Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese HanY T Chang
Mol Psychiatry 7:828-9. 2002
- Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapsesJian Wang
Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1
J Neurosci 23:826-36. 2003..Thus, an activity-dependent physical and functional interaction between CaN and GABA(A) receptors is both necessary and sufficient for inducing LTD at CA1 individual inhibitory synapses...
- Association analysis of exonic variants of the GABA(B)-receptor gene and alpha electroencephalogram voltage in normal subjects and alcohol-dependent patientsGeorg Winterer
Department of Psychiatry, Benjamin Franklin University Hospital, Free University of Berlin, Berlin, Germany
Behav Genet 33:7-15. 2003....
- Absence of GABRA1 Ala322Asp mutation in juvenile myoclonic epilepsy families from IndiaA Kapoor
Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560 064, India
J Genet 82:17-21. 2003An Ala322Asp mutation in the GABRA1 gene was recently reported to be responsible for causing the autosomal dominant (AD) form of juvenile myoclonic epilepsy (JME) in a French-Canadian family...
- A mutation in the GABAA receptor alpha 1 subunit linked to human epilepsy affects channel gating propertiesJanet L Fisher
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Blg 1 Rm D23, Columbia, SC 29209, USA
Neuropharmacology 46:629-37. 2004..Therefore, production of the mutated subunit could cause global hyperexcitability throughout the brain, leading to generalized seizures with juvenile onset...
- Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulationDirk Rüsch
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
J Biol Chem 279:20982-92. 2004..This model also correctly predicts the actions of etomidate on GABA(A) receptors containing a point mutation that increases constitutive gating activity...
- GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cellsMacarena Peran
Departamento de Bioquimica, Facultad de Medicina, Universidad de Malaga, Campus de Teatinos, Malaga 29080, Spain
Neurosci Lett 364:67-70. 2004..We show that the alpha1 and alpha6 subunits immobilize recombinant GABAAR in transfected cells. This is consistent with the immobility of native receptors in CG cells, which express alpha1 and alpha6...
- The juvenile myoclonic epilepsy GABA(A) receptor alpha1 subunit mutation A322D produces asymmetrical, subunit position-dependent reduction of heterozygous receptor currents and alpha1 subunit protein expressionMartin J Gallagher
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37212, USA
J Neurosci 24:5570-8. 2004....
- Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndromeAnthony R Isles
Neurobiology and Developmental Genetics Programmes, The Babraham Institute, Cambridge, UK
Hum Mol Genet 13:1849-55. 2004..levels of a number of GABAA subunits previously shown to be important components of fear processing (Gabra3, Gabra1 and Gabrg2) were also altered...
- Shelley J Russek; Fiscal Year: 2016..identified long-term changes in GABAR a subunit gene expression, including decreases in expression of the a1 gene (Gabra1) in rat hippocampal dentate granule neurons following status epilepticus (SE) that are associated with later ..
- Martin J Gallagher; Fiscal Year: 2014..The hypotheses to be tested are: 1) because 11 subunit expression increases throughout development, GABRA1 epilepsy mutations will reduce total GABAAR subunit protein and produce neurons with smaller IPSC amplitudes ..
- GABA-A Receptor Gene Transfer to Prevent EpileptogenesisSHELLEY RUSSEK; Fiscal Year: 2004..expression play a critical role in the process of epileptogenesis by re- establishing normal levels of GABRA4 and GABRA1 following pilocarpine-induced SE and determining whether development of spontaneous seizures is subsequently ..
- Parent and Peer Influences on Alcohol Use Problems: A Genetically Informed StudyKAITLIN ELIZABETH BOUNTRESS; Fiscal Year: 2013..g. DRD2, DAT1, GABRA1, and OPRM1)...
- Vulnerability Factors and Drinking in AdulthoodMichael Windle; Fiscal Year: 2009..The DNA from the 782 adults will be used to conduct candidate gene analyses for GABRA2, GABRA1, CHRM2, CRHR1, CNR1, 5HTTLPR, and DRD2 for alcohol and depression phenotypes...
- Dimensions and Polarity of Anesthetic Binding SItesJames Trudell; Fiscal Year: 2004..Building a more complete 3-dimensional model of an anesthetic binding site will allow us to define those molecular properties that confer distinct pharmacologies on volatile anesthetics. ..
- Properties of Specific Alcohol Binding SitesJames Trudell; Fiscal Year: 2009..The results may reveal general motifs for action in other systems affected by alcohol and aid in the design of alcohol antagonists. ..
- TREATMENT FOR ALCHOLISM: A PRIMATE MODELKELLY COSGROVE; Fiscal Year: 2002..Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated. ..
- Lafora's Progressive Myoclonus EpilepsyAntonio Delgado Escueta; Fiscal Year: 2003..3) Search for the second gene (EPM2B) for Lafora's PME. These advances raise our hopes for developing treatment(s) for this fatal epilepsy. ..
- PKA & PKC REGULATION OF NT2-N & RECOMBINANT GABARSRobert MacDonald; Fiscal Year: 2003..7) The NT2 and NT2-N GABAR subtype protein phosphorylated by PKA and PKC. 8) The biophysical mechanisms PKA and PKC modification of NT2 and NT2-N GABAR currents. ..
- GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURESRobert MacDonald; Fiscal Year: 2003....
- Physiologic Analysis of Two GABAR Gamma2-Subunit DomainsMartin Gallagher; Fiscal Year: 2006..Such an environment maximizes the probability that the principal investigator will establish a scientific niche and embark upon a successful independent academic career. ..
- Structural Determinants of GABA-A receptor functionJanet Fisher; Fiscal Year: 2007..The results of this work will help us to understand how variations in the alpha subunit composition of native GABARs can affect the properties of neurons and their responses to GABA. ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..