FUT3

Summary

Gene Symbol: FUT3
Description: fucosyltransferase 3 (Lewis blood group)
Alias: CD174, FT3B, FucT-III, Les, galactoside 3(4)-L-fucosyltransferase, Lewis FT, alpha-(1,3/1,4)-fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group), fucosyltransferase III
Species: human

Top Publications

  1. ncbi Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specific
    B W Weston
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109 0650
    J Biol Chem 267:4152-60. 1992
  2. doi Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria
    Eva Maria Matzhold
    Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    Transfusion 49:2097-108. 2009
  3. ncbi Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels
    T F Orntoft
    Department of Clinical Biochemistry, Skejby University Hospital, DK 8200 Aarhus N, Denmark
    J Biol Chem 271:32260-8. 1996
  4. ncbi Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa
    H Pang
    Department of Forensic Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Hum Genet 102:675-80. 1998
  5. doi Genetic variation of FUT3 in Ghanaians, Caucasians, and Mongolians
    Mikiko Soejima
    Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Transfusion 49:959-66. 2009
  6. ncbi A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase
    J F Kukowska-Latallo
    Howard Hughes Medical Institute, Ann Arbor, Michigan
    Genes Dev 4:1288-303. 1990
  7. pmc High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas
    Zahra Madjd
    Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK
    Breast Cancer Res 7:R780-7. 2005
  8. ncbi Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
  9. pmc Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:3256-64. 2005
  10. ncbi Typing for the human lewis blood group system by quantitative fluorescence-activated flow cytometry: large differences in antigen presentation on erythrocytes between A(1), A(2), B, O phenotypes
    G Larson
    Department of Clinical Chemistry and Transfusion Medicine, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Vox Sang 77:227-36. 1999

Scientific Experts

Detail Information

Publications154 found, 100 shown here

  1. ncbi Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specific
    B W Weston
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109 0650
    J Biol Chem 267:4152-60. 1992
    ..These results are consistent with the hypothesis that this gene encodes the human "plasma type" alpha(1,3)fucosyltransferase, and suggest a molecular basis for a family of human alpha(1,3)fucosyltransferase genes...
  2. doi Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria
    Eva Maria Matzhold
    Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    Transfusion 49:2097-108. 2009
    Genes for fucosyltransferases 1 (FUT1:H), 2 (FUT2:Secretor), and 3 (FUT3:Lewis) encode enzymes crucial for ABH and Lewis blood group antigen synthesis. They are highly polymorphic and ethnically and geographically specific.
  3. ncbi Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels
    T F Orntoft
    Department of Clinical Biochemistry, Skejby University Hospital, DK 8200 Aarhus N, Denmark
    J Biol Chem 271:32260-8. 1996
    ..The Lewis gene, FUT3, encodes the only known alpha1-4-fucosyltransferase (FucT), and individuals who are deficient in this enzyme type ..
  4. ncbi Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa
    H Pang
    Department of Forensic Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Hum Genet 102:675-80. 1998
    Five novel missense mutations, viz., C304 A, T370 G, G484 A, G667 A, and G808 A, in the Lewis gene (FUT3) were detected in African (Xhosa) and Caucasian individuals in South Africa...
  5. doi Genetic variation of FUT3 in Ghanaians, Caucasians, and Mongolians
    Mikiko Soejima
    Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Transfusion 49:959-66. 2009
    The FUT3 gene regulates the expression of Lewis blood group antigens. Several lines of evidence suggest association between expression of these antigens and Helicobacter pylori infection or susceptibility to cardiovascular diseases...
  6. ncbi A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase
    J F Kukowska-Latallo
    Howard Hughes Medical Institute, Ann Arbor, Michigan
    Genes Dev 4:1288-303. 1990
    ....
  7. pmc High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas
    Zahra Madjd
    Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK
    Breast Cancer Res 7:R780-7. 2005
    ..The SC101 mAb is a unique Lewisy/b binding antibody that binds to native and extended Lewisy and Lewisb haptens, displaying no cross reactivity with H type 1, H type 2, Lewisx or normal blood group antigens...
  8. ncbi Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
    The human alpha(1,3)-fucosyltransferase genes FUT3, FUT5, and FUT6 form a cluster on chromosome 19p13.3. Expression was studied using reverse transcriptase-polymerase chain reaction, rapid amplification of cDNA ends, and Northern analyses...
  9. pmc Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:3256-64. 2005
    ..The presence of such a DC-SIGN-binding molecule in human milk may both influence antigenic presentation and interfere with pathogen transfer in breastfed infants...
  10. ncbi Typing for the human lewis blood group system by quantitative fluorescence-activated flow cytometry: large differences in antigen presentation on erythrocytes between A(1), A(2), B, O phenotypes
    G Larson
    Department of Clinical Chemistry and Transfusion Medicine, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Vox Sang 77:227-36. 1999
    ..Now genomic typing of the Lewis gene is available. Additionally, flow cytometry has been used for typing. We wanted to compare the results of Lewis typing in healthy individuals using the three methods...
  11. doi Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes
    Kristina Nyström
    Department of Virology, University of Gothenburg, Gothenburg, Sweden
    Glycobiology 19:847-59. 2009
    ..after transcriptional activation of different combinations of dormant human fucosyltransferase genes (FUT1, FUT3, FUT5, and FUT6), whose gene products are responsible for the synthesis of Le antigens...
  12. pmc Mechanisms of GII.4 norovirus persistence in human populations
    Lisa C Lindesmith
    University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Med 5:e31. 2008
    ..4 strains is common in human populations. In this article, we analyze molecular mechanisms governing GII.4 epidemiology, susceptibility, and persistence in human populations...
  13. ncbi Biosynthesis and expression of the Sda and sialyl Lewis x antigens in normal and cancer colon
    Nadia Malagolini
    Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    Glycobiology 17:688-97. 2007
    ....
  14. ncbi Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue
    S Nishihara
    Division of Cell Biology, Institute of Life Science, Soka University, Tokyo, Japan
    FEBS Lett 462:289-94. 1999
    ..fucosylated the distal GlcNAc residue of the polylactosamine chain while the other four alpha1,3FUT members, FUT3, FUT4, FUT5 and FUT6, preferentially fucosylated the inner GlcNAc residue...
  15. ncbi FUT4 and FUT9 genes are expressed early in human embryogenesis
    A Cailleau-Thomas
    U 504 INSERM, Universite de Paris Sud XI, 94807 Villejuif, France
    Glycobiology 10:789-802. 2000
    ..b>FUT3, FUT5, FUT6, and FUT7 were not detected by Northern blot...
  16. ncbi Structure-function analysis of human alpha 1-->3fucosyltransferases. A GDP-fucose-protected, N-ethylmaleimide-sensitive site in FucT-III and FucT-V corresponds to Ser178 in FucT-IV
    E H Holmes
    Pacific Northwest Research Foundation, Seattle, Washington 98122, USA
    J Biol Chem 270:8145-51. 1995
    ..These results support the importance of Ser178 of FucT-IV in donor substrate binding and strongly suggest analogous Cys residues are the GDP-fucose protectable, N-ethylmaleimide-sensitive sites present in FucT-III and -V...
  17. ncbi [Identification of the hemolytic transfusion reaction caused by lewis antibody using serological and molecular biological methods]
    Xiao zhen Hong
    Institute of Transfusion Medicine, Ministry of Health, Hangzhou, 310006, Zhejiang Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:1192-5. 2008
    ..phenotype was identified by using anti-Le(a) and anti-Le(b) blood grouping reagents and the entire coding region of FUT3 gene was amplified by PCR and sequenced directly...
  18. ncbi Molecular cloning and expression of a bovine alpha(1,3)-fucosyltransferase gene homologous to a putative ancestor gene of the human FUT3-FUT5-FUT6 cluster
    A Oulmouden
    Institut de Biotechnologie, Faculte des Sciences, Universite de Limoges, 87060 Limoges, France
    J Biol Chem 272:8764-73. 1997
    Only one bovine gene, corresponding to the human cluster of genes FUT3-FUT5-FUT6, was found by Southern blot analysis. The cognate bovine alpha(1,3)-fucosyltransferase shares 67.3, 69.0, and 69...
  19. ncbi Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases
    Peng Guo
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
    FEBS Lett 562:93-8. 2004
    ..However, it did not cause the increase of SLe(x) synthesis. Transfection of antisense GnTV into H7721 cells showed entirely opposite effects on the expression of above-mentioned SLe(x) and glycosyltransferases as the sense GnTV...
  20. ncbi Substrate and donor specificity of glycosyl transferases
    B Ernst
    University of Basel, Institute of Molecular Pharmacy, Switzerland
    Glycoconj J 16:161-70. 1999
    ..A survey of the involved enzymes: beta(1-3) and beta(1-4)galactosyl transferases, alpha(2-3)sialyl transferase, FucT III and FucT VI reveals that the enzymatic synthesis is highly efficient for the rapid preparation of sialyl Lewis(x)-..
  21. ncbi Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21
    R S McCurley
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Genomics 26:142-6. 1995
    ..We have established physical maps of the FUT3-6 loci to study regulation of this gene family...
  22. ncbi [Clinical evaluation of lung abscess diagnosed by transtracheal aspiration]
    M Konishi
    Second Department of Internal Medicine, Nara Medical University
    Kansenshogaku Zasshi 72:1193-6. 1998
    ..A temperature higher than 38 degrees C was present in 12 patients but temperature les than 37 degrees C in 2. Multiple microorganisms were cultured from TTA in 15 patients. A mean of 2...
  23. ncbi Complete genomic organization of futb encoding a bovine alpha 3-fucosyltransferase: exons in human orthologous genes emerged from ancestral intronic sequences
    A Wierinckx
    Unité de Génétique Moléculaire Animale Université INRA, Universite de Limoges, France
    Mol Biol Evol 16:1535-47. 1999
    ..A short sequence of the latter is homologous to distinct 5'-UT exons of FUT6 (alpha 3-fucosylation) and FUT3 (alpha 4-fucosylation), two human genes whose coding sequences are homologous to coding exon e of futb...
  24. ncbi "Les maladies héréditaires:" 18th century disputes in France
    C López-Beltrán
    Instituto de Investigaciones Filosóficas, Ciudad Universitaria, Mexico
    Rev Hist Sci Paris 48:307-50. 1995
    ..These developments turned out to be crucial for the emergence and strength of 19th century French (and European) hereditarianism, in medicine and other fields...
  25. ncbi Sequence context strongly modulates association of polar residues in transmembrane helices
    Jessica P Dawson
    Department of Molecular Biophysics and Biochemistry, Yale University, Bass Centre Room 420A, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
    J Mol Biol 331:255-62. 2003
    ..occurring TM domains that contain a Glu or Gln residue (Tnf5/CD40 ligand, C79a/Ig-alpha, C79b/Ig-beta, and Fut3/alpha-fucosyltransferase); and (ii)...
  26. ncbi Cytogenetics, conserved synteny and evolution of chicken fucosyltransferase genes compared to human
    P Coullin
    UMR 8125, Cytogénétique et génomique des cancers, Institut Gustave Roussy, Villejuif, France
    Cytogenet Genome Res 103:111-21. 2003
    ..For the two remaining loci, FUT9 and FUT3/5/6, the location may correspond to a new small syntenic area or to an insertion...
  27. ncbi Histo-blood group antigen and human milk oligosaccharides: genetic polymorphism and risk of infectious diseases
    Jacques Le Pendu
    INSERM U419, Institut de Biologie, 9 quai Moncousu, F 44093, Nantes, France
    Adv Exp Med Biol 554:135-43. 2004
    ..Their biosynthesis largely is controlled by the enzyme products of alleles at the ABO, FUT2 and FUT3 loci. We have shown that Norwalk virus (NV) uses structures based on H type 1 as its primary receptor...
  28. ncbi Glycosyltransferases involved in type 1 chain and Lewis antigen biosynthesis exhibit glycan and core chain specificity
    Jan Holgersson
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Glycobiology 16:584-93. 2006
    ..The latter enzyme could use both core 2 and core 3 precursor structures. Furthermore, the specificity of FUT5 and FUT3 in Le(a) and Le(b) synthesis was different, with FUT5 fucosylating H type 1 only on core 2, but FUT3 fucosylating H ..
  29. ncbi Exploring specificity of glycosyltransferases: synthesis of new sugar nucleotide related molecules as putative donor substrates
    Amira Khaled
    Glycochimie Moléculaire et Macromoléculaire, Laboratoire de Chimie Organique Multifonctionnelle, UMR 8182, Institut de Chimie Moleculaire et des Materiaux d Orsay, Batiment 420, Univ Paris Sud, F 91405 Orsay, France
    Carbohydr Res 343:167-78. 2008
    ..The surrogate of UDP-GlcNAc that was already known as its protected acetylated derivative, tested as N-acetylglucosamine donor with LgtA in the presence of Mn(2+) turned out not to be active either...
  30. doi Comprehensive profiles of human milk oligosaccharides yield highly sensitive and specific markers for determining secretor status in lactating mothers
    Sarah M Totten
    Department of Chemistry, University of California, Davis, California 95616, United States
    J Proteome Res 11:6124-33. 2012
    ..different blood types differ in the expression of α1,2 fucosyltransferase (FUT2) and α1,3/4 fucosyltransferase (FUT3)...
  31. pmc The Lewis histo-blood group system: molecular analysis of the 59T>G, 508G>A, and 1067T>A polymorphisms in an Amazonian population
    Tereza Cristina de Oliveira Corvelo
    Immunogenetics Laboratory, Biological Sciences Institute, Federal University of Para, Belem, Para, Brazil
    PLoS ONE 8:e69908. 2013
    The Lewis (FUT3) gene is responsible for the expression of the Le(a) and Le(b) blood group antigens...
  32. doi Glycosyltransferases as marker genes for the quantitative polymerase chain reaction-based detection of circulating tumour cells from blood samples of patients with breast cancer undergoing adjuvant therapy
    Alexandra C Kölbl
    Department of Obstetrics and Gynecology, Ludwig Maximilians University of Munich, Munich D 80337, Germany
    Mol Med Rep 12:2933-8. 2015
    ..b>FUT3 and GALNT6 showed the highest increase in relative expression, while GALNT6 and ST3GAL3 were the first to reach ..
  33. doi Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384
    Juxiang Huang
    Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China
    Immunol Res 64:461-9. 2016
    ..Our identified BIK interactive total feedback molecular network showed FUT3 [fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase Lewis blood group)], PMM2 (phosphomannomutase 2), ..
  34. doi Association of elevated rotavirus-specific antibody titers with HBGA secretor status in Swedish individuals: The FUT2 gene as a putative susceptibility determinant for infection
    Gökçe Günaydin
    Department of Laboratory Medicine, Division of Clinical Immunology and Transfusion Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
    Virus Res 211:64-8. 2016
    ..We investigated the effect of inactivating mutations in the secretor FUT2 (rs601338) and Lewis FUT3 genes (rs28362459, rs3894326, rs812936 and rs778986) on serum IgG antibody titers and neutralizing antibody titers ..
  35. pmc Association of Ulcerative Colitis with FUT2 and FUT3 Polymorphisms in Patients from Southeast China
    Dingyuan Hu
    Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    PLoS ONE 11:e0146557. 2016
    Dysbiosis of intestinal microbiota has been implicated in ulcerative colitis (UC). Fucosyltransferase (FUT) 2 and FUT3 determine expression of histo-blood group antigens in the gut and may affect the intestinal microbiota...
  36. doi Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer
    Takahiro Osuga
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan Division of Clinical Oncology Division of Molecular Oncology, Sapporo Medical University Graduate School of Medicine, Sapporo, Japan
    J Natl Cancer Inst 108:. 2016
    ..With this in mind, we examined requirement of L-fucose in CRC cells and developed fucose-bound nanoparticles as vehicles for delivery of anticancer drugs specific to CRC...
  37. pmc Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..In contrast, lower esophageal sphincter (LES) contraction induced by maximally effective doses of ACh is mediated by muscarinic M3 receptors, linked to ..
  38. ncbi Development and application of a high resolution liquid chromatographic method for the analysis of complex pigment distributions
    R L Airs
    Department of Chemistry, University of York, Heslington, UK
    J Chromatogr A 917:167-77. 2001
    ..significantly more pigment components in extracts from a sediment (Priest Pot, Cumbria, UK), a microbial mat (les Salines de la Trinital, South Catalonia, Spain) and a culture (C...
  39. ncbi Lewis Antigens, alpha1,3 Fucosyltransferses and the Metastatic Potential of Human Primary Liver Cancer
    Fei Liu
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical University
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32:115-120. 2000
    ....
  40. ncbi Reversible model of spheroid formation allows for high efficiency of gene delivery ex vivo and accurate gene assessment in vivo
    Mary L Alpaugh
    Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Hum Gene Ther 13:1245-58. 2002
    ..a dominant-negative E-cadherin mutant (H-2K(d)-E-cad), its control (H-2K(d)-E-cad Delta C25), or alpha-1,3-fucosyltransferase III (FucT-III), an enzyme that increases surface sLe(x/a), were used to transfect either intact (wild-type) or ..
  41. pmc Relationship of sialyl-Lewis(x/a) underexpression and E-cadherin overexpression in the lymphovascular embolus of inflammatory breast carcinoma
    Mary L Alpaugh
    Department of Pathology, University of California at Los Angeles School of Medicine, Los Angeles, California 90024, USA
    Am J Pathol 161:619-28. 2002
    ..Our findings support the cooperative relationship of sLe(x/a) underexpression and E-cadherin overexpression in the genesis of the lymphovascular embolus of IBC...
  42. ncbi Analysis of lewis antigens on cell surface and alpha1,3 fucosyltransferase subtypes in H7721 human hepatocarcinoma cells
    P Guo
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, School of Medicine, Fu Dan University, Shanghai, China
    J Exp Clin Cancer Res 22:135-9. 2003
    ..The absence of FucT-IX expression and FucT-III not being the rate-limiting enzyme for SLea synthesis may be the reasons for the negligible expressions of Lex and SLea on the cell surface, respectively...
  43. ncbi Enzymatic synthesis of the core-2 sialyl Lewis X O-glycan on the tumor-associated MUC1a' peptide
    Ricardo Gutiérrez Gallego
    Section of Glycoscience and Biocatalysis, Department of Bio Organic Chemistry, Bijvoet Center, Utrecht University, The Netherlands
    Biochimie 85:275-86. 2003
    ..All products were characterized by mass spectrometry and NMR spectroscopy...
  44. ncbi Identification of two new single-nucleotide polymorphisms in FUT3 associated with the Lewis-null phenotype
    Laura Cooling
    Transfusion 43:1760-1. 2003
  45. ncbi Two novel FUT3 alleles responsible for Lewis-null phenotypes in Sri Lanka
    Mikiko Soejima
    Transfusion 44:1534-5. 2004
  46. ncbi Synthesis of unnatural sugar nucleotides and their evaluation as donor substrates in glycosyltransferase-catalyzed reactions
    Amira Khaled
    Laboratoire de Chimie Organique Multifonctionnelle, UMR 8614, GDR 2590, Institut de Chimie Moléculaire et des Matériaux d Orsay ICMMO, Universite Paris Sud, Bat 420, F 91405 Orsay, France
    Carbohydr Res 339:2641-9. 2004
    ..1% efficiency as compared with UDP-GlcNAc, the natural donor substrate...
  47. ncbi Influence of the combined ABO, FUT2, and FUT3 polymorphism on susceptibility to Norwalk virus attachment
    Severine Marionneau
    INSERM U601, Institut de Biologie, Nantes, France
    J Infect Dis 192:1071-7. 2005
    ..Partial fucosidase treatment of duodenal tissue sections and binding to a synthetic probe with varying densities of H type 1 trisaccharide indicated that optimal attachment occurred at medium ligand density...
  48. doi Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis
    Thomas M Moehler
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    J Cell Physiol 215:27-36. 2008
    ..We investigated whether cell surface expression of the carbohydrate blood group determinant Lewis(y) (CD174) and its precursor structure H2 (CD173) on endothelial cells is influenced by soluble factors of tumor cells...
  49. pmc Lewis y antigen promotes the proliferation of ovarian carcinoma-derived RMG-I cells through the PI3K/Akt signaling pathway
    Juanjuan Liu
    Department of Obstetrics and Gynecology, China Medical University Shengjing, Hospital, 36 Sanhao Street, Heping, Shenyang, 110004, PR China
    J Exp Clin Cancer Res 28:154. 2009
    ..This study was to investigate the effect and the possible mechanism of Lewis y on the proliferation of human ovarian cancer cells...
  50. doi Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression
    Rickard Nordén
    Department of Virology, University of Gothenburg, Guldhedsgatan 10B, Goteborg, Sweden
    Arch Virol 155:305-13. 2010
    ..Lewis X in infected cells by activating transcription of three normally silent host glycosyltransferase genes, FUT3, FUT5, and FUT6, a process that is initiated by binding of viral RNA to cellular protein kinase R...
  51. doi The relationship between Lewis/Secretor genotypes and serum carbohydrate antigen 19-9 levels in a Korean population
    Hyung Doo Park
    Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Lab Med 30:51-7. 2010
    ....
  52. pmc Knockdown of fucosyltransferase III disrupts the adhesion of circulating cancer cells to E-selectin without affecting hematopoietic cell adhesion
    Xiaoyan Yin
    Department of Biomedical Engineering, Cornell University, 205 Weill Hall, Ithaca, NY 14853, USA
    Carbohydr Res 345:2334-42. 2010
    ..RT-PCR, we demonstrated that FUT4 and FUT7 are the predominant FUTs expressed in hematopoietic cell line, while FUT3 is heavily expressed by multiple cancer cell lines including the prostate cancer cell line MDA PCa2b...
  53. pmc Neutrophil interactions with sialyl Lewis X on human nonsmall cell lung carcinoma cells regulate invasive behavior
    Catherine A St Hill
    Department of Veterinary Clinical Sciences, University of Minnesota, Veterinary Medical Center, St Paul, Minnesota, USA
    Cancer 117:4493-505. 2011
    ....
  54. doi Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults
    Jennifer E Huffman
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK
    Hum Mol Genet 20:5000-11. 2011
    ..glycan features in 2705 individuals from three European populations, that polymorphisms at three loci (FUT8, FUT6/FUT3 and HNF1A) affect plasma levels of N-glycans...
  55. doi CA-S27: a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma
    Atit Silsirivanit
    Department of Biochemistry, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 104:1278-84. 2013
    ..Fucosyltransferase-III (FUT3) was shown to be a regulator of CA-S27 expression...
  56. doi Associations of FUT2 and FUT3 gene polymorphisms with Crohn's disease in Chinese patients
    Ding yuan Hu
    Department of Gastroenterology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    J Gastroenterol Hepatol 29:1778-85. 2014
    FUT2 and FUT3 genes are responsible for the formation of histo-blood group antigens, which act as binding sites for some intestinal microbes...
  57. pmc Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China
    Yu Liang
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People s Republic of China
    PLoS ONE 9:e97923. 2014
    ..However, the genetic determinants of sCEA level in healthy and CRC population remains unclear. Thus we investigated the genetic markers associated with elevated serum sCEA level in these two populations and its clinical implications...
  58. pmc Increased fucosylation has a pivotal role in invasive and metastatic properties of head and neck cancer stem cells
    Vincenzo Desiderio
    Department of Otolaryngology, Medical School, University of Michigan, Ann Arbor, MI, USA Department of Experimental Medicine, Section of Biotechnology and Medical Histology and Embryology, Second University of Naples, Italy
    Oncotarget 6:71-84. 2015
    ..We found fucosyltransferases FUT3 and FUT6 highly up-regulated, increased SLex expression and increased adhesion by shear flow assays in orospheres...
  59. pmc Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways
    Ana Magalhaes
    Institute for Research and Innovation in Health i3S, University of Porto, Portugal Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Portugal
    Biochim Biophys Acta 1852:1928-39. 2015
    ..increased expression of sialyl-Lewis a/x antigens due to transcriptional up-regulation of the B3GNT5, B3GALT5, and FUT3 genes. We observed that H...
  60. doi Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis
    Andreas Wannhoff
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany
    Clin Gastroenterol Hepatol 13:2372-9. 2015
    ..cholangitis, the CA19-9 level can be affected by variants in the fucosyltransferases 2 and 3 genes (FUT2 and FUT3), which regulate the production of CA19-9...
  61. pmc Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis
    Arti Yadav
    The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America
    PLoS ONE 10:e0141602. 2015
    ..E-selectin knockdown in EC-Bcl-2 cells or FAK/FUT3 knockdown in tumor cells significantly reversed EC-Bcl-2-mediated tumor metastasis...
  62. doi A Furan-Based Lewis-Y-(CD174)-Saccharide Mimetic Inhibits Endothelial Functions and In Vitro Angiogenesis
    Sandra Sauer
    Department of Medicine V, University of Heidelberg, Germany
    Adv Clin Exp Med 24:759-68. 2015
    ..Angiogenesis is a fundamental process underlying cancer progression and autoimmune disease. Lewis Y is known as a regulated glycan-structure supporting human endothelial function and angiogenesis...
  63. pmc Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin)
    Adrien Breiman
    INSERM U892, CNRS UMR6299, University of Nantes, 44007 Nantes, France
    Oncotarget 7:14064-82. 2016
    ..g.: Lewis Y) is decreased as a result of repression of the fucosyltransferase genes FUT1 and FUT3. Moreover, we identify the fucose-binding bacterial lectin BC2L-C-Nt as a specific probe for the epithelial state...
  64. doi Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei
    Pirjo Nummela
    Pathology, Research Programs Unit, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland Electronic address
    Hum Pathol 54:47-54. 2016
    ..CA19-9 showed strong immunopositivity in most of the tumors (91.3%), and mutated enzyme FUT3 was demonstrated from the cases showing negative or weak staining...
  65. doi A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes
    Neeraja M Krishnan
    Ganit Labs, Bio IT Centre, Institute of Bioinformatics and Applied Biotechnology, Bangalore, India
    Mol Cancer Res 14:805-19. 2016
    ..Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of certain clinical and ..
  66. ncbi Effect of FUT3 gene silencing with miRNA on proliferation, invasion and migration abilities of human KATO-III gastric cancer cell line
    Y J Cai
    Fourth People s Hospital of Jinan, Taishan Medical College Department of Blood Transfusion Jinan China
    Cell Mol Biol (Noisy-le-grand) 62:15-20. 2016
    This study investigated the effects of FUT3 gene expression inhibition with miRNA on the proliferation, invasion and migration abilities of KATO-III cells. KATO-III cells were transfected with plasmid pcDNA™6...
  67. ncbi Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor
    J Yang
    Center for Hemostasis and Thrombosis Research, Division of Hematology Oncology, New England Medical Center, Boston, MA, USA
    Blood 87:4176-86. 1996
    ..PSGL-1 on mouse myeloid cells is critical for high-affinity binding to P-selectin but not E-selectin...
  68. ncbi Lewis(y) antigen (CD174) and apoptosis in gastric and colorectal carcinomas: correlations with clinical and prognostic parameters
    S E Baldus
    Intitute of Pathology, University of Duesseldorf, Duesseldorf, Germany
    Histol Histopathol 21:503-10. 2006
    Lewis(y) (Le(y)), also designated CD174, represents a carbohydrate blood group antigen which is strongly expressed in neoplastic gastrointestinal tissues. Previous reports indicated an association between Le(y) expression and apoptosis...
  69. doi Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes
    Debora Barreto Teresa
    School of Pharmaceutical Sciences, UNESP, University of Sao Paulo State, Rua Expedicionários do Brasil, 1621, 14 801 902, Araraquara, Sao Paulo, Brazil
    Tumour Biol 31:401-9. 2010
    ..Nonsecretor genotype was associated with axillary lymph node metastasis (P = 0.0149). In conclusion, Lewis and Secretor genotyping could be useful to predict respectively breast cancer susceptibility and axillary lymph nodes metastasis...
  70. doi Difucosylated oligosaccharide Lewis Y is contained within integrin αvβ3 on RL95-2 cells and required for endometrial receptivity
    Dongmei Zhang
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian, People s Republic of China
    Fertil Steril 95:1446-51.e1. 2011
    ..To investigate whether Lewis Y (LeY) carried by integrin αvβ3 influences integrin αvβ3-mediated adhesion in an in vitro implantation model...
  71. doi [Genetic susceptibility to norovirus infection]
    N Ruvoen
    Unité de maladies réglementées zoonoses, ONIRIS Ecole Nationale Vétérinaire, Agroalimentaire et de l alimentation Nantes Atlantique, Site de la Chantrerie, 44307 Nantes, France
    Pathol Biol (Paris) 61:28-35. 2013
    ..Synthesis of these HBGAs requires various glycosyltransferase encoded by the ABO, FUT2, FUT3 genes...
  72. ncbi Persistent Helicobacter pylori infection and genetic polymorphisms of the host
    Nobuyuki Hamajima
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 66:103-17. 2003
    ..To date, the associations with the polymorphisms of fucosyl transferase 2 (FUT2 or secretor gene), FUT3 (Lewis gene), interleukin 1A (IL-1A), IL-1B, IL-1RN, IL-8, IL-10, myeloperoxidase (MPO), and tumor necrosis factor ..
  73. ncbi Biochemical characterization of Silene alba alpha4-fucosyltransferase and Lewis a products
    R Leonard
    Laboratoire de Chimie des Substances Naturelles, Groupe de Glycobiologie Forestière EA1069, Faculté des Sciences et Techniques de Limoges, Limoges, France
    Glycoconj J 22:71-8. 2005
    ..In contrast to human FUT3, the S. alba alpha4-FucT was insensitive to N-ethylmaleimide (NEM) treatment. Measurement of enzyme activity in S...
  74. ncbi Molecular mechanisms of Lewis antigen expression
    Mikiko Soejima
    Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume 830 0011, Japan
    Leg Med (Tokyo) 7:266-9. 2005
    ..In this review, we describe the regulation the expression of type 1 Lewis antigens on erythrocytes or digestive organs by two genes (FUT2 and FUT3), and the ethnic specificity of the polymorphism of these genes for forensic use.
  75. ncbi A single aromatic amino acid at the carboxyl terminus of Helicobacter pylori {alpha}1,3/4 fucosyltransferase determines substrate specificity
    Bing Ma
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 280:36848-56. 2005
    ..Notably, a single aromatic residue (Trp) has also been implicated in controlling Type I acceptor preference for human FucT III, but it is located in an N-terminal hypervariable stem domain.
  76. ncbi Chemoenzymatic synthesis of the 3-sulfated Lewisa pentasaccharide
    Annie Malleron
    Laboratoire de Chimie Organique Multifonctionnelle, UMR 8614, GDR 2590, Bat 420, Universite de Paris Sud, F 91405 Orsay, France
    Carbohydr Res 341:29-34. 2006
    ..The fucosylation of the sulfated tetrasaccharide was performed using soluble or immobilized fucosyltransferase FucT-III to give the title compound...
  77. ncbi Non-isosteric C-glycosyl analogues of natural nucleotide diphosphate sugars as glycosyltransferase inhibitors
    Sébastien Vidal
    Laboratoire de Chimie Organique 2, UMR CNRS 5181, Universite Claude Bernard Lyon 1, CPE Lyon Bâtiment 308, 43 Boulevard du 11 Novembre 1918, F 69622 Villeurbanne, France
    Bioorg Med Chem 14:7293-301. 2006
    ..vitro inhibitory activity of UDP-Gal, GDP-Fuc and UDP-GlcNAc analogues towards glycosyltransferases (beta-1,4-GalT, FUT3 and LgtA) was evaluated through a competition fluorescence assay and IC(50) values of 40 microM, 2 mM and 3...
  78. ncbi Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines
    C Escrevente
    Instituto de Tecnologia Quimica e Biologica, 2781 901 Oeiras, Portugal
    Int J Oncol 29:557-66. 2006
    ..synthetic carbohydrate acceptors and Western blot analysis we concluded that Lea, sLea and Leb were synthesised by FUT3, whereas Lex and Ley were synthesized by FUT4 and FUT9 in both cell lines...
  79. pmc C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells
    Catherine A St Hill
    Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 6:e16281. 2011
    ..Our findings indicate that C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential...
  80. pmc Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition
    Keiichiro Sakuma
    Division of Molecular Pathology, Aichi Cancer Center, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Proc Natl Acad Sci U S A 109:7776-81. 2012
    ..The transcript levels of the glycosyltransferase genes ST3GAL1/3/4 and FUT3 were significantly elevated and that of FUT2 was significantly suppressed by the treatment...
  81. pmc Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion
    Wesley F Zandberg
    Department of Chemistry, Simon Fraser University, 8888 University Dr, Burnaby V5A 1S6, Canada
    J Biol Chem 287:40021-30. 2012
    ..GDP-5T-Fuc itself does not get transferred by either FUT3 or FUT7 at a measurable rate...
  82. doi Virus-induced appearance of the selectin ligand sLeX in herpes simplex virus type 1-infected T-cells: involvement of host and viral factors
    Rickard Nordén
    Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden
    Glycobiology 23:310-21. 2013
    ..found that HSV1 infection of a T-cell line resulted in transcriptional activation of human fucosyltransferase genes FUT3, FUT6 and FUT7, the two latter genes encoding the fucosyltransferases rate limiting for sLeX synthesis...
  83. pmc Molecular characterization of noroviruses and HBGA from infected Quilombola children in Espirito Santo State, Brazil
    Fernando Vicentini
    Departamento de Ciências da Saúde, Universidade Federal do Espirito Santo, São Mateus, Espirito Santo, Brazil
    PLoS ONE 8:e69348. 2013
    ..HBGA phenotype was performed by gel-spinning and FUT2 and FUT3 were analyzed by PCR or sequencing analysis. NoV were detected in 9.2% (12/131) of diarrheic and 1...
  84. doi FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
    Andreas Wannhoff
    Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany
    J Hepatol 59:1278-84. 2013
    ..We aimed at improving diagnostic accuracy of CA19-9 by determining the impact of FUT2/3 genotypes...
  85. doi Noroviruses and histo-blood groups: the impact of common host genetic polymorphisms on virus transmission and evolution
    Nathalie Ruvoën-Clouet
    Unité de maladies réglementées zoonoses, ONIRIS Ecole Nationale Vétérinaire, Agroalimentaire et de l alimentation Nantes Atlantique, Nantes, France INSERM, UMR 892 CNRS, UMR 6299, Universite de Nantes, Nantes, France
    Rev Med Virol 23:355-66. 2013
    ..synthesis of these HBGAs requires the action of several glycosyltransferases that are encoded by the ABO, FUT2, and FUT3 genes...
  86. pmc The human milk metabolome reveals diverse oligosaccharide profiles
    Jennifer T Smilowitz
    Departments of Food Science and Technology
    J Nutr 143:1709-18. 2013
    ..and products of the FUT2 gene and negative correlations between fucose and products of the fucosyltransferase 3 (FUT3) gene...
  87. pmc α3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration
    Jennifer C Brazil
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, GA 30322
    J Immunol 191:4804-17. 2013
    ..Analyses of glycosyltransferase expression identified fucosyltransferase 3 (Fut3) as the key enzyme driving sLe(a) biosynthesis in human intestinal epithelial cells (IECs)...
  88. ncbi The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand
    K L Koszdin
    Ciba Geigy Corp, Summit, NJ 07901
    Biochem Biophys Res Commun 187:152-7. 1992
    ..The substrate specificity of the FucT-VI gene product suggests that FucT-VI may be an enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis x, in myeloid cells...
  89. ncbi Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19
    I Reguigne-Arnould
    INSERM U 178, Villejuif, France
    Cytogenet Cell Genet 71:158-62. 1995
    ..7) and 9 cM proximal to D19S571 (lod score 11.7). Polymorphic markers of FUT3, FUT5, and FUT6 were used for linkage analysis with 14 Généthon microsatellites in Indonesian families...
  90. ncbi Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19
    S Nishihara
    Division of Cell Biology, Soka University, Tokyo, Japan
    Biochem Biophys Res Commun 190:42-6. 1993
    ..These genes were present 13 kb apart in tandem orientation. The FucT-III gene has already been mapped on the Lewis locus of chromosome 19. This demonstrated that FucT-VI gene was localized close to the Lewis locus on chromosome 19...
  91. ncbi Molecular genetic analysis of the human Lewis histo-blood group system
    S Nishihara
    Division of Cell Biology, Soka University, Tokyo, Japan
    J Biol Chem 269:29271-8. 1994
    ..The frequency of occurrence of Le, le1, and le2 in the Japanese population by random sampling study was found to be 66, 30, and 4%, respectively...
  92. ncbi Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees
    R Mollicone
    INSERM U 178, Villejuif, France
    J Biol Chem 269:20987-94. 1994
    ..They are synthesized by two fucosyltransferases, encoded by Lewis (FUT3) and secretor (FUT2) loci...
  93. ncbi Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals
    Y Koda
    Department of Legal Medicine, School of Medicine, Kurume University, Japan
    Blood 82:2915-9. 1993
    ..We isolated the protein-coding region of the Lewis FT cDNA from Le(+) and Le(-) gastric mucosa by polymerase chain reaction (PCR) amplification...
  94. ncbi Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals
    T Kudo
    Division of Cell Biology, Institute of Life Science, Soka University, Tokyo, Japan
    J Biol Chem 271:9830-7. 1996
    ..The phylogenic aspect and biological significance of the Se and Le genes are discussed...
  95. ncbi A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein
    E C Brinkman Van der Linden
    Department of Medical Chemistry, Faculty of Medicine, Van der Boechorststraat 7, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
    J Biol Chem 271:14492-5. 1996
    ..in the liver, we studied the fucosylation of three glycoproteins in sera of individuals with or without inactivated FUT3 and/or FUT6 gene(s) but with a functional FUT5 gene...
  96. ncbi Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII
    A Elmgren
    Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    J Biol Chem 272:21994-8. 1997
    The Lewis alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII, encoded by the FUT3 gene is responsible for the final synthesis of Lea and Leb antigens...
  97. ncbi Evolution of fucosyltransferase genes in vertebrates
    M Costache
    INSERM U178, Universite de Paris Sud XI, 94807 Villejuif Cedex, France
    J Biol Chem 272:29721-8. 1997
    Cloning and expression of chimpanzee FUT3, FUT5, and FUT6 genes confirmed the hypothesis that the gene duplications at the origin of the present human cluster of genes occurred between: (i) the great mammalian radiation 80 million years ..
  98. ncbi Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines
    E Mas
    INSERM U 260, Unité de Recherche de Physiopathologie des Régulations Hormono Nutritionnelles, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Glycobiology 8:605-13. 1998
    ..Transcripts of FUT1, FUT2, FUT3, FUT4, FUT5, and FUT7 were detected by RT-PCR in carcinoma cell lines as well as in normal and tumoral tissues...
  99. ncbi Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells
    B W Weston
    The Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Cancer Res 59:2127-35. 1999
    ..by stable transfection of antisense sequences directed at the human Lewis alpha(1,3/1,4)fucosyltransferase gene, FUT3. The metastatic parental cell line, HT-29LMM, expressed high levels of sialyl Lewis x, sialyl Lewis a, alpha(1,3/1,..
  100. ncbi Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia
    S Yazawa
    Japan Immunoresearch Laboratories, Takasaki, Japan
    Exp Clin Immunogenet 16:125-30. 1999
    ..Genotyping of the Le gene (FUT3) in these patients demonstrated that 2 of them were also FUT3 deficient and were grouped as Lewis- individuals ..
  101. ncbi Molecular analysis of secretor type alpha(1,2)-fucosyltransferase gene mutations in the Chinese and Thai populations
    J G Chang
    Department of Medical Research and Pediatrics, China Medical College Hospital, Taichung, Taiwan
    Transfusion 39:1013-7. 1999
    ..of fucosyltransferase genes alpha(1,2)-fucosyltransferase (FUT2 or Se) and alpha(1,3/1,4)-fucosyltransferase (FUT3 or Le), are responsible for the polymorphism of Lewis blood group phenotypes...

Research Grants4

  1. Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.
    Ardythe L Morrow; Fiscal Year: 2013
    ..Sialyl Lewis a (sLe ) is a major glycan produced by the combined catalytic function of transferases encoded by the FUT3 and a2-3 sialyl transferase genes...
  2. Distinctive Glycan Fingerprints of Pancreatic Cancer for Plasma Detection
    David E Misek; Fiscal Year: 2013
    ..These over-expressed or altered tumor glycoproteins may have utility as biomarkers for early detection of PDAC. ..
  3. EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTS
    Brent Weston; Fiscal Year: 2004
    ..of these glycans on human colon cancer cells is largely controlled by the alpha(1,3)fucosyltransferases FUT3 and FUT6...
  4. Genetic Modifiers in CF: Role of ABH polymorphisms
    JENNIFER TAYLOR COUSAR; Fiscal Year: 2006
    ..1) Determine whether polymorphisms in genes in the ABH pathway (including ABO, FUT2 [Secretor status], and FUT3 [Lewis antigen]) segregate with "severe" or "mild" lung disease, or with CF pathogen colonization; (2) Determine ..