FUNDC1

Summary

Gene Symbol: FUNDC1
Description: FUN14 domain containing 1
Alias: FUN14 domain-containing protein 1
Species: human

Top Publications

  1. pmc Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy
    Ming Chen
    a State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Autophagy 12:689-702. 2016
  2. pmc Interaction of FUN14 domain containing 1, a mitochondrial outer membrane protein, with kinesin light chain 1 via the tetratricopeptide repeat domain
    Won Hee Jang
    Department of Biochemistry, Inje University College of Medicine, Busan 614 735, Republic of Korea
    Biomed Rep 6:46-50. 2017
  3. pmc Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy
    Ziheng Chen
    State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    EMBO Rep . 2017
  4. pmc Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury
    Weilin Zhang
    The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    elife 5:. 2016
  5. pmc Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
    Mengqi Lv
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China
    Protein Cell 8:25-38. 2017
  6. pmc Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy
    Yao Kuang
    a Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, School of Life Sciences, Peking University, Beijing, China
    Autophagy 12:2363-2373. 2016
  7. pmc In Brief: Mitophagy: mechanisms and role in human disease
    Maya Z Springer
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, USA
    J Pathol 240:253-255. 2016
  8. pmc FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy
    Wenxian Wu
    a Guangdong Key Laboratory of Age related Cardiac cerebral Vascular Disease, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong China
    Autophagy 12:1675-6. 2016
  9. pmc FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions
    Wenxian Wu
    Guangdong Key Laboratory of Age related Cardiac cerebral Vascular Disease, Department of Neurology, Institute of Neurology, the Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China
    EMBO J 35:1368-84. 2016
  10. pmc The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy
    Hao Wu
    State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing, China University of Chinese Academy of Sciences Beijing, China
    Autophagy 10:1712-25. 2014

Scientific Experts

  • A Terracciano
  • Lei Liu
  • Quan Chen
  • Du Feng
  • Wenxian Wu
  • Yushan Zhu
  • Hao Wu
  • Wen Li
  • Guo Chen
  • Jun Wang
  • Chongzhuo Zhu
  • Xiaohui Wang
  • Senfang Sui
  • Ziheng Chen
  • Weilin Zhang
  • Bin Zhao
  • Liangqing Zhang
  • Zhe Han
  • Ming Chen
  • Changqian Zhou
  • Longxuan Li
  • Won Hee Jang
  • Mengqi Lv
  • Yueying Wang
  • Yanjun Li
  • Lei Jiang
  • Hao Chen
  • Maya Z Springer
  • Yao Kuang
  • Runzhi Zhu
  • Linbo Chen
  • Xingliang Zhang
  • Haixia Zhuang
  • Xingli Zhang
  • Weili Tian
  • Zhe Hu
  • Qi Ma
  • Li Huang
  • Peng Xue
  • Haijing Jin
  • Lei Huang
  • Sang Hwa Urm
  • Dae Hyun Seog
  • Qi Cheng
  • Sheikh Arslan Sehgal
  • Bin Wen
  • Junhui Peng
  • Young Joo Jeong
  • Sun Hee Choi
  • Yunyu Shi
  • Sami Siraj
  • Qingguo Gong
  • Chongyuan Wang
  • Yajun Tang
  • Fudong Li
  • Chunxia Lin
  • Dong Liu
  • Bin Xia
  • Ming Zheng
  • Xiaojing Wang
  • Ning Tan
  • Kay F Macleod
  • JingJing Wang
  • Zheng Tan
  • Jingjing Zhang
  • Wei Li
  • Ruize Gao
  • Kaili Ma
  • Lei Du
  • Yue Yang
  • Chunling Xu
  • Junling Liu
  • Chuanmao Zhang
  • Pengfei Ding
  • Shupeng Li
  • Yue Lu
  • He Ren
  • Keng Wu
  • Sijie Wang
  • Changying Fu
  • Xiangyu Cai
  • Yuequan Shen
  • Xinqi Liu
  • Kaori Sakakibara
  • Danfeng Xue
  • He Ge Chen
  • Yanfang Chen
  • Ying Li
  • Yusen Chen
  • Yinqin Chen

Detail Information

Publications17

  1. pmc Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy
    Ming Chen
    a State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Autophagy 12:689-702. 2016
    ..We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif to initiate mitophagy in mammalian ..
  2. pmc Interaction of FUN14 domain containing 1, a mitochondrial outer membrane protein, with kinesin light chain 1 via the tetratricopeptide repeat domain
    Won Hee Jang
    Department of Biochemistry, Inje University College of Medicine, Busan 614 735, Republic of Korea
    Biomed Rep 6:46-50. 2017
    ..of the current study revealed an interaction between the TPR domain of KLC1 and FUN14 domain-containing protein 1 (FUNDC1), which is a mitochondrial outer membrane protein mediating hypoxia-induced mitophagy...
  3. pmc Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy
    Ziheng Chen
    State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    EMBO Rep . 2017
    ..is activated by two distinct pathways, one dependent on ubiquitin and the other dependent on receptors including FUNDC1. It is not clear whether these pathways coordinate to mediate mitophagy in response to stresses, or how mitophagy ..
  4. pmc Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury
    Weilin Zhang
    The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    elife 5:. 2016
    ..Hypoxia induced extensive mitochondrial degradation in a FUNDC1-depenent manner in platelets, and this was blocked by in vivo administration of a cell-penetrating peptide ..
  5. pmc Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
    Mengqi Lv
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China
    Protein Cell 8:25-38. 2017
    ..Fun14 domain-containing protein 1 (FUNDC1) was reported to be a new receptor for hypoxia-induced mitophagy in mammalian cells and interact with microtubule-..
  6. pmc Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy
    Yao Kuang
    a Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, School of Life Sciences, Peking University, Beijing, China
    Autophagy 12:2363-2373. 2016
    ..Several mitophagy receptors, including the newly identified FUNDC1, mediate selective removal of damaged or superfluous mitochondria through their specific interaction with LC3...
  7. pmc In Brief: Mitophagy: mechanisms and role in human disease
    Maya Z Springer
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, USA
    J Pathol 240:253-255. 2016
    ..PINK1/Parkin partnership, which modulates turnover of depolarized mitochondria, and stress-induced BNIP3, NIX, and FUNDC1 molecular adaptors, which interact directly with LC3 to promote mitophagy...
  8. pmc FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy
    Wenxian Wu
    a Guangdong Key Laboratory of Age related Cardiac cerebral Vascular Disease, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong China
    Autophagy 12:1675-6. 2016
    ..We have shown that the outer mitochondrial membrane protein FUNDC1 is a novel mitochondrial-associated membrane (MAM) protein, enriched at the MAM by interacting with the ER ..
  9. pmc FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions
    Wenxian Wu
    Guangdong Key Laboratory of Age related Cardiac cerebral Vascular Disease, Department of Neurology, Institute of Neurology, the Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China
    EMBO J 35:1368-84. 2016
    ..MAM) is essential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein FUNDC1 interacts with LC3 to recruit autophagosomes, but the mechanisms integrating these processes are poorly understood...
  10. pmc The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy
    Hao Wu
    State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing, China University of Chinese Academy of Sciences Beijing, China
    Autophagy 10:1712-25. 2014
    ..We previously have identified FUNDC1 as a mitophagy receptor for selectively removing damaged mitochondria in mammalian systems...
  11. pmc Receptor-mediated mitophagy in yeast and mammalian systems
    Lei Liu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Cell Res 24:787-95. 2014
    ..Several protein receptors, including Atg32 in yeast, NIX/BNIP3L, BNIP3 and FUNDC1 in mammalian systems, directly act in mitophagy...
  12. doi A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy
    Guo Chen
    State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin 300071, China
    Mol Cell 54:362-77. 2014
    ..Interactions between LC3 and mitophagy receptors such as FUNDC1, which harbors an LC3-interacting region (LIR), are essential for this selective process...
  13. pmc ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
    Wenxian Wu
    Institute of Neurology, Guangdong Key Laboratory of Age related Cardiac cerebral Vascular Disease, Affiliated Hospital of Guangdong Medical College, Zhanjiang Guangdong, China
    EMBO Rep 15:566-75. 2014
    ..At mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to LC3...
  14. pmc MicroRNA-137 is a novel hypoxia-responsive microRNA that inhibits mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX
    Wen Li
    From the Institute of Neurology, Guangdong Key Laboratory of Age related Cardiac cerebral Vascular Disease
    J Biol Chem 289:10691-701. 2014
    ..miR-137 targets the expression of two mitophagy receptors NIX and FUNDC1. Impaired mitophagy in response to hypoxia caused by miR-137 is reversed by re-expression of FUNDC1 and NIX ..
  15. doi Molecular signaling toward mitophagy and its physiological significance
    Du Feng
    Key Laboratory of Age associated Cardiac cerebral Vascular Disease of Guangdong Province, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China
    Exp Cell Res 319:1697-705. 2013
    ..have been discovered in different physiological settings, including ATG32 in yeast as well as NIX, BNIP3, and FUNDC1 in mammalian cells...
  16. doi Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
    Lei Liu
    The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Nat Cell Biol 14:177-85. 2012
    ..Here we report that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy...
  17. pmc Genome-wide association scan for five major dimensions of personality
    A Terracciano
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Mol Psychiatry 15:647-56. 2010
    ..We infer that a large number of loci may influence personality traits and disorders, requiring larger sample sizes for the GWA approach to confidently identify associated genetic variants...