FTO

Summary

Gene Symbol: FTO
Description: FTO, alpha-ketoglutarate dependent dioxygenase
Alias: ALKBH9, BMIQ14, GDFD, alpha-ketoglutarate-dependent dioxygenase FTO, AlkB homolog 9, fat mass and obesity associated, fat mass and obesity-associated protein
Species: human

Top Publications

  1. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
  2. pmc Life course variations in the associations between FTO and MC4R gene variants and body size
    Rebecca Hardy
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
    Hum Mol Genet 19:545-52. 2010
  3. pmc FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies
    Jens K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetes 60:1637-44. 2011
  4. ncbi Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
  5. pmc The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
  6. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
  7. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
  8. doi Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
    Karani S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
    Am J Clin Nutr 90:425-8. 2009
  9. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  10. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010

Research Grants

  1. Ellen A Schur; Fiscal Year: 2015
  2. MICHAEL L CAMILLERI; Fiscal Year: 2014
  3. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
  4. EDWARD ANTONIO RUIZ-NARVAEZ; Fiscal Year: 2016
  5. Chuan He; Fiscal Year: 2016
  6. Susan Carnell; Fiscal Year: 2015
  7. Michael Rosenbaum; Fiscal Year: 2016
  8. DIANE IHN AE GILBERT-DIAMOND; Fiscal Year: 2014
  9. Paul T Williams; Fiscal Year: 2014
  10. Rudolph L Leibel; Fiscal Year: 2016

Detail Information

Publications277 found, 100 shown here

  1. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
    Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans...
  2. pmc Life course variations in the associations between FTO and MC4R gene variants and body size
    Rebecca Hardy
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
    Hum Mol Genet 19:545-52. 2010
    ..We genotyped variants in FTO (rs9939609) and near MC4R (rs17782313) in 1240 men and 1239 women born in 1946 and participating in the MRC ..
  3. pmc FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies
    Jens K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetes 60:1637-44. 2011
    b>FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span.
  4. ncbi Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
    We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12...
  5. pmc The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
    Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans...
  6. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ..After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2...
  7. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
  8. doi Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
    Karani S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
    Am J Clin Nutr 90:425-8. 2009
    Intronic variation in the FTO (fat mass and obesity-associated) gene has been unequivocally associated with increased body mass index (BMI; in kg/m(2)) and the risk of obesity in populations of different ethnicity.
  9. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  10. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  11. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    Common FTO (fat mass and obesity associated) gene variants have recently been associated with body mass index (BMI) and obesity in several large studies...
  12. ncbi The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
    Kerstin Wahlen
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Lipid Res 49:607-11. 2008
    We investigated the rs9939609 single nucleotide polymorphism of the FTO gene in relation to fat cell function and adipose tissue gene expression in 306 healthy women with a wide range in body mass index (18-53 kg/m(2))...
  13. pmc Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
    ..expressed homeobox (HHEX; rs 1111875); transcription factor-7-like 2 (TCF7L2; rs 10885409); potassium inwardly rectifying channel subfamily J member 11(KCNJ11; rs 5219); and fat mass obesity-associated gene (FTO; rs 9939609)].
  14. pmc FTO genetic variation and association with obesity in West Africans and African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 59:1549-54. 2010
    The FTO gene is one of the most consistently replicated loci for obesity. However, data from populations of African ancestry are limited...
  15. pmc Prevalence of loss-of-function FTO mutations in lean and obese individuals
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 59:311-8. 2010
    Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass- and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(-/-) mice are lean and Fto(+/-) mice are resistant to diet-induced obesity...
  16. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk...
  17. pmc FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome
    Kathryn G Ewens
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e16390. 2011
    ..While not associated with PCOS itself, five SNPs in FTO and two in MC4R were associated with BMI as assessed with a quantitative-TDT analysis, several of which replicated ..
  18. pmc Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
    Amanda F Marvelle
    Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 57:1987-91. 2008
    ..The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort...
  19. doi Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study
    Vanessa Legry
    INSERM, U744, Lille, France
    Metabolism 58:971-5. 2009
    We investigated the association between the rs9939609 (T>A) polymorphism in the FTO (fat mass- and obesity-associated) gene and obesity- and type 2 diabetes mellitus-related phenotypes in the French Multinational MONItoring of Trends ..
  20. pmc Common body mass index-associated variants confer risk of extreme obesity
    Chris Cotsapas
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Hum Mol Genet 18:3502-7. 2009
    ..We found convincing association to the previously described locus including the FTO gene...
  21. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  22. pmc PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 4:e7643. 2009
    ..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
  23. pmc Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    Frida Renstrom
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Hum Mol Genet 18:1489-96. 2009
    Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...
  24. pmc FTO gene variation and measures of body mass in an African population
    Branwen J Hennig
    MRC International Nutrition Group, NPHIRU, EPH, London School of Hygiene and Tropical Medicine, London, UK
    BMC Med Genet 10:21. 2009
    Variation in the fat mass and obesity associated (FTO) gene has been reproducibly associated with body mass index (BMI) and obesity in populations of White European origin. Data from Asians and African-Americans is less conclusive.
  25. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried by 46% of Western Europeans and is associated with an approximately 1...
  26. pmc The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China
    Bo Xi
    Department of Epidemiology, Capital Institute of Pediatrics, 2 Ya Bao Road, 100020 Beijing China
    BMC Med Genet 11:107. 2010
    ..for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European children and adults...
  27. pmc Regulation of Fto/Ftm gene expression in mice and humans
    George Stratigopoulos
    Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1185-96. 2008
    ..studies (GWAS) in European populations have associated a approximately 47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear...
  28. doi Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations
    Wei Huang
    Division of Endocrinology, Department of Puren Hospital, Wuhan University of Science and Technology, Wuhan, China
    Endocrine 39:69-74. 2011
    Genetic variants of FTO and MC4R have been linked with obesity and T2DM in populations of Europeans...
  29. pmc Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004
    Mika Kivimaki
    Department of Epidemiology and Public Health, Faculty of Biomedical Sciences, University College London, United Kingdom
    Am J Epidemiol 173:421-9. 2011
    ..obesity and common mental disorders (CMD) by utilizing the known relation between fat mass and obesity-associated (FTO) genotype and body mass index (BMI; weight (kg)/height (m)(2))...
  30. pmc FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106 7281, USA
    Carcinogenesis 32:748-56. 2011
    ..Polymorphisms in the fat-mass and obesity-associated (FTO) gene have been associated with BMI and larger effects in older versus younger children have been reported...
  31. pmc Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth
    Gaifen Liu
    Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, The Netherlands
    Eur J Epidemiol 26:463-73. 2011
    Recent genome-wide association (GWA) studies identified several common variants for obesity: rs9939609 in FTO, rs7566605 near INSIG2 and both rs17782313 and rs17700633 near the MC4R gene...
  32. doi β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals
    Mette Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 97:E1074-9. 2012
    ..The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes...
  33. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  34. pmc FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness
    Sofia I I Kring
    Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
    PLoS ONE 3:e2958. 2008
    A common single nucleotide polymorphism (SNP) of FTO (rs9939609, T/A) is associated with total body fatness...
  35. pmc Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling
    Marika Kaakinen
    Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland
    Am J Epidemiol 172:653-65. 2010
    The association between variation in the fat mass and obesity-associated (FTO) gene and adulthood body mass index (BMI; weight (kg)/height (m)(2)) is well-replicated...
  36. doi Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study
    Eryn T Liem
    Department of Pediatrics Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    Am J Clin Nutr 91:321-8. 2010
    ..Overweight is a complex trait in which both environmental and genetic factors play a role...
  37. doi A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Circ Cardiovasc Genet 2:260-9. 2009
    b>FTO is the first gene established as contributing to common forms of obesity. The gene is highly expressed in the hypothalamus and is thought to mediate this effect through its influence on energy homeostasis...
  38. pmc FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males
    Robert A Scott
    Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Hum Genet 18:1339-43. 2010
    Studies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk...
  39. doi The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study
    Tiina J Lappalainen
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 17:832-6. 2009
    The common single-nucleotide polymorphism in the FTO (fat mass and obesity associated) gene is consistently associated with an increased risk of obesity...
  40. pmc The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924
    Josefin A Jacobsson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    BMC Med Genet 10:131. 2009
    Common FTO (fat mass and obesity associated) gene variants have recently been strongly associated with body mass index and obesity in several large studies...
  41. ncbi Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population
    Shigeru Karasawa
    Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
    Endocr J 57:293-301. 2010
    The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 +/- 10.2 years), a Japanese community-based study...
  42. doi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  43. pmc The fat mass- and obesity-associated locus and dietary intake in children
    Nicholas J Timpson
    MRC CAiTE Centre, Department of Social Medicine, Bristol University, Bristol, UK
    Am J Clin Nutr 88:971-8. 2008
    A region of chromosome 16 containing the fat mass-and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity.
  44. doi An obesity-associated FTO gene variant and increased energy intake in children
    Joanne E Cecil
    Bute Medical School, University of St Andrews, St Andrews, United Kingdom
    N Engl J Med 359:2558-66. 2008
    Variation in the fat mass and obesity-associated (FTO) gene has provided the most robust associations with common obesity to date. However, the role of FTO variants in modulating specific components of energy balance is unknown.
  45. doi Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
    Emily Sonestedt
    Department of Clinical Sciences in Malmo, Nutrition Epidemiology, Lund University, Malmo, Sweden
    Am J Clin Nutr 90:1418-25. 2009
    The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation.
  46. pmc The FTO gene rs9939609 obesity-risk allele and loss of control over eating
    Marian Tanofsky-Kraff
    Unit on Growth and Obesity, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
    Am J Clin Nutr 90:1483-8. 2009
    Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT).
  47. pmc FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2472-80. 2008
    The FTO gene was recently identified as a susceptibility locus for both obesity and type 2 diabetes by whole-genome association analyses of several European populations...
  48. doi Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women
    Qun Yan
    Shanghai Key Laboratory for Endocrine Tumors, Shanghai Institute of Endocrine and metabolic Disease, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Lu, 200025 Shanghai, People s Republic of China
    Endocrine 36:377-82. 2009
    Variations in the fat mass and obesity-associated (FTO) gene have recently been associated with obesity and type 2 diabetes mellitus among different ethnic populations...
  49. pmc Evaluation of genetic susceptibility loci for obesity in Chinese women
    Jiajun Shi
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Epidemiol 172:244-54. 2010
    ..Two SNPs near the BAT2 and MC4R genes and 3 SNPs within the FTO, SEC16B, and SH2B1 genes were significantly associated with body mass index (weight (kg)/height (m)(2)), body ..
  50. doi Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans
    Hye Ja Lee
    Division of Metabolic Disease, Center for Biomedical Sciences, National Institute of Health, 194 Tongillo, Eunpyung Gu, Seoul 122 701, Republic of Korea
    Clin Chim Acta 411:1716-22. 2010
    Associations with FTO (fat mass and obesity associated) gene variants and BMI have been reported in western adult populations...
  51. doi Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population
    Kikuko Hotta
    Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    J Hum Genet 55:738-42. 2010
    ..factor AP-2β (TFAP2B), methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes...
  52. pmc The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women
    Tariq Ahmad
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 160:1163-9. 2010
    Variation in the Fat-Mass and Obesity-Associated (FTO) gene has been associated with obesity, diabetes, and hypertension...
  53. doi Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence
    Agnieszka Sobczyk-Kopciol
    Department of General Biology and Parasitology, Medical University of Warsaw, Poland
    Addiction 106:739-48. 2011
    To investigate whether the FTO rs9939609 A allele (a risk factor for obesity) is associated with measures of alcohol consumption.
  54. doi The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men
    Christian Benedict
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Neurobiol Aging 32:1159.e1-5. 2011
    Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries...
  55. pmc The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
    Virginia Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine and Robert H, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 676 N St Clair st suite 850, Chicago, IL 60611, USA
    BMC Med Genet 12:52. 2011
    Obesity has been shown to increase breast cancer risk. FTO is a novel gene which has been identified through genome wide association studies (GWAS) to be related to obesity...
  56. doi Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 56:647-51. 2011
    ..are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1...
  57. pmc The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents
    D M Hallman
    Human Genetics Center, University of Texas School of Public Health, Houston, TX 77225, USA
    Int J Obes (Lond) 36:61-8. 2012
    To investigate possible age-related changes in associations between polymorphisms in the fat mass and obesity-associated (FTO) gene and higher body mass index (BMI).
  58. pmc A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 141:2219-25. 2011
    Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce...
  59. pmc Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia
    Rebekah Karns
    Department of Environmental Health, University of Cincinnati College of Medicine, OH, USA
    Ann Hum Genet 76:17-24. 2012
    The association between obesity and the fat mass and obesity-associated (FTO) gene has been widely replicated among Caucasian populations...
  60. doi Genome wide analysis reveals association of a FTO gene variant with epigenetic changes
    Markus Sällman Almén
    Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala, Sweden
    Genomics 99:132-7. 2012
    Variants of the FTO gene show strong association with obesity, but the mechanisms behind this association remain unclear. We determined the genome wide DNA methylation profile in blood from 47 female preadolescents...
  61. doi High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults
    Catherine M Phillips
    Nutrigenomics Research Group, University College Dublin School of Public Health and Population Science, University College Dublin Conway Institute, Dublin, Ireland
    J Nutr 142:824-31. 2012
    Fat mass and obesity-associated (FTO) is the strongest genetic determinant of obesity identified to date. Dietary fat is a key environmental factor that may interact with genotype to affect risk of obesity and metabolic syndrome (MetS)...
  62. pmc Variations in the FTO gene are associated with severe obesity in the Japanese
    Kikuko Hotta
    Laboratory for Obesity, SNP Research Center, RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Hum Genet 53:546-53. 2008
    Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese...
  63. pmc 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
    We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this ..
  64. doi Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Obesity (Silver Spring) 17:330-4. 2009
    ..Variation at the fat-mass and obesity-associated (FTO) gene locus has been reported to be associated with increased body fat...
  65. pmc Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men
    Esther Zimmermann
    Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
    PLoS ONE 4:e4428. 2009
    The A-allele of the single nucleotide polymorphism (SNP), rs9939609, in the FTO gene is associated with increased fatness. We hypothesized that the SNP is associated with morbidity and mortality through the effect on fatness.
  66. doi Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France
    R Attaoua
    IURC, Molecular Endocrinology Laboratory UMR 204, Montpellier Cedex 5, France
    Diabetes Metab 35:476-83. 2009
    The objective of the present study was to investigate the genetic association of the fat-mass-and-obesity-associated (FTO) gene in obese women in the presence of the known influential role of the insulin receptor substrate 2 (IRS-2) gene.
  67. doi Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study
    Jonatan R Ruiz
    Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Huddinge, Sweden
    Arch Pediatr Adolesc Med 164:328-33. 2010
    To examine whether physical activity attenuates the effect of the FTO rs9939609 polymorphism on body fat estimates in adolescents.
  68. pmc Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 5:e10521. 2010
    Single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene are associated with body mass index (BMI) in populations of European descent...
  69. pmc Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women
    Tariq Ahmad
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Diabetes Care 34:675-80. 2011
    Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains unclear.
  70. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
    ..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
  71. pmc Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO)
    Michael Linnebacher
    Department of General, Thoracic, Vascular and Transplant Surgery, University of Rostock, Rostock, Germany
    J Biomed Biotechnol 2010:841451. 2010
    ..Here, we provide conclusive data that the (-1) frame of U79260(FTO) encodes an HLA-A0201-restricted cytotoxic T cell epitope (FSP11; TLSPGWSAV)...
  72. doi Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome
    T M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK
    Diabetologia 51:1153-8. 2008
    Variants in the fat-mass and obesity-associated gene (FTO) influence susceptibility to type 2 diabetes via an effect on adiposity/obesity...
  73. doi Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain
    José L González-Sánchez
    Department of Internal Medicine II, Hospital Clinico San Carlos, Madrid, Spain
    Clin Endocrinol (Oxf) 70:390-3. 2009
    Recently independent studies, including genome-wide scans, have shown that variation in the fat mass and obesity associated gene (FTO) were significantly associated with obesity in populations of European origin.
  74. doi Variation in the FTO gene influences food intake but not energy expenditure
    A Haupt
    Department of Internal Medicine, Division of Diabetology, Endocrinology, Nephrology and Angiology, Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Exp Clin Endocrinol Diabetes 117:194-7. 2009
    Polymorphisms in the FTO (fat mass- and obesity-associated) gene are associated with obesity. The mechanisms how genetic variation in this gene influences body weight are unknown...
  75. doi Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults
    A Jonsson
    Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Diabetologia 52:1334-8. 2009
    Recent reports have suggested that genotypes at the FTO locus interact with physical activity to modify levels of obesity-related traits...
  76. pmc Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
    Anke Tonjes
    Department of Medicine, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
    Eur J Hum Genet 18:104-10. 2010
    The association between common variants in the FTO gene with weight, adiposity and body mass index (BMI) has now been widely replicated...
  77. doi The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients
    Carina Zabena
    Department of Internal Medicine II, Hospital Clinico San Carlos, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Cea Bermúdez 66, 5 G, 28003, Madrid, Spain
    Obes Surg 19:87-95. 2009
    Obesity has emerged as one of the most serious public health concerns in the twenty-first century. the fat mass and obesity associated gene (FTO) has been found to contribute to the risk of obesity in humans...
  78. pmc Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
    Susanne Tan
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:12. 2010
    ..We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS...
  79. doi Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction
    B K Cornes
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Int J Obes (Lond) 33:75-9. 2009
    To further investigate a common variant (rs9939609) in the fat mass- and obesity-associated gene (FTO), which recent genome-wide association studies have shown to be associated with body mass index (BMI) and obesity.
  80. pmc Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls
    S F Field
    Diabetologia 50:2218-20. 2007
  81. pmc Association of the FTO gene with BMI
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 16:902-4. 2008
    Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects...
  82. doi Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans
    N Kloting
    Department of Medicine, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetologia 51:641-7. 2008
    Recently, FTO was identified as a candidate gene contributing to both childhood and severe adult obesity...
  83. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.
  84. doi Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
    J K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetologia 51:971-7. 2008
    ..To get a better estimation of the true risk conferred by these novel loci, we tested a completely unselected population of type 2 diabetes patients from a Norwegian health survey (the HUNT study)...
  85. doi The FTO gene is associated with adulthood obesity in the Mexican population
    Marisela Villalobos-Comparan
    Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México, Mexico City, Mexico
    Obesity (Silver Spring) 16:2296-301. 2008
    Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations...
  86. doi Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents
    J A Jacobsson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    Int J Obes (Lond) 32:1730-5. 2008
    ..Recent genome-wide association studies have provided strong support for association between variants in the FTO gene and obesity...
  87. pmc Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program
    P W Franks
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    Diabetologia 51:2214-23. 2008
    The single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity associated gene (FTO) and the rs7566605 SNP located 10 kb upstream of the insulin-induced gene 2 gene (INSIG2) have been proposed as risk factors for common ..
  88. doi Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, 59000 Lille, France
    Nat Genet 41:157-9. 2009
    ..Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal ..
  89. doi Common genetic variation near MC4R is associated with eating behaviour patterns in European populations
    F Stutzmann
    1CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Int J Obes (Lond) 33:373-8. 2009
    Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation...
  90. doi Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study
    Y Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Int J Obes (Lond) 33:1243-8. 2009
    Susceptibility of fat mass and obesity-associated (FTO) gene polymorphisms to obesity has been reported in various populations. Polymorphisms in the melanocortin 4 receptor (MC4R) gene were recently explored as another susceptible locus...
  91. pmc The Common FTO Genetic Polymorphism rs9939609 is Associated with Increased BMI in Type 1 Diabetes but not with Diabetic Nephropathy
    Harvest F Gu
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden email
    Biomark Insights 5:29-32. 2010
    The fat mass and obesity associated (FTO) gene has an important genetic effect on body mass index (BMI) and risk of obesity, and obesity contributes to the progression of renal diseases, including diabetic nephropathy...
  92. pmc Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
    ..Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight...
  93. pmc Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population
    Yi Cheng Chang
    Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
    Diabetes 57:2245-52. 2008
    Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations...
  94. doi FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome
    Redha Attaoua
    Molecular Endocrinology Laboratory, IURC, 641 Avenue du Doyen Gaston Giraud, 34093 Montpellier Cedex 5, France
    Biochem Biophys Res Commun 373:230-4. 2008
    The FTO (Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans...
  95. doi Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies
    C Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 40:722-6. 2008
    ..0008-0.0004]. In addition, we found evidence for association of SNPs in the genes PPARG, IGF2BP2, HHEX, TCF7L2, and FTO with type 2 diabetes in the same directions as previously described (p<0...
  96. doi A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    Yoon Shin Cho
    Center for Genome Science, National Institute of Health, Seoul, Korea
    Nat Genet 41:527-34. 2009
    ..2 x 10(-3), P = 1.4 x 10(-7) and P = 6.0 x 10(-4), respectively). This large-scale GWA analysis of well-characterized Korean population-based samples highlights previously unknown biological pathways...
  97. doi A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake
    Ann L Hasselbalch
    Institute of Preventive Medicine, Copenhagen Capital Region, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
    J Nutr 140:831-4. 2010
    We investigated the role of the fat mass and obesity associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) in modulating habitual intake of total energy and macronutrients, glycemic index, glycemic load, dietary ..
  98. pmc Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS Genet 6:e1000916. 2010
    ..Apart from previously identified FTO, MC4R, and TMEM18, we detected two new loci for obesity: one in SDCCAG8 (serologically defined colon cancer antigen ..
  99. doi Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79)
    Kandaswamy Ramya
    Madras Diabetes Research Foundation, ICMR Advanced Centre for Genomics of Type 2 Diabetes and Dr Mohan s Diabetes Specialities Centre, Gopalapuram, Chennai, India
    Diabetes Technol Ther 13:33-42. 2011
    ..and rs1588413 (in intron 8), and rs11076023 (3' untranslated region)-across three regulatory regions of the fat mass and obesity-associated (FTO) gene with obesity and type 2 diabetes mellitus (T2DM) in a South Indian population.
  100. doi Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition
    Cristina Razquin
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Irunlarrea 1, Pamplona, Navarra, Spain
    Mol Nutr Food Res 55:136-49. 2011
    ..study of the effects of melanocortin 4 receptor, Peroxisome proliferator-activated receptor γ and fat mass and obesity associated (FTO) gene variants and their interactions with dietary intake, physical activity or drug ..
  101. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI)...

Research Grants47

  1. Ellen A Schur; Fiscal Year: 2015
    ..All twins will be genotyped for variant alleles in the fat mass and obesity-associated (FTO) gene, one of the most common obesity susceptibility genes, in order to compare brain response to visual food cues ..
  2. MICHAEL L CAMILLERI; Fiscal Year: 2014
    ..g. fat mass and obesity-associated gene, FTO) or type II diabetes mellitus (DM, e.g. TCF7L2)...
  3. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..in measuring children's eating behaviour and has published on genetic influences, including effects of the FTO gene...
  4. EDWARD ANTONIO RUIZ-NARVAEZ; Fiscal Year: 2016
    ..Because the FTO gene, the gene most strongly associated with fat mass and obesity in AA as well as European ancestry populations, ..
  5. Chuan He; Fiscal Year: 2016
    ..complexes, will be applied to study other AlkB human homologues, in particular, ABH3, a prostate cancer marker, and FTO, a major factor involved in obesity and energy homeostasis...
  6. Susan Carnell; Fiscal Year: 2015
    ..in measuring children's eating behaviour and has published on genetic influences, including effects of the FTO gene...
  7. Michael Rosenbaum; Fiscal Year: 2016
    ..An extremely common (allelic frequency of ~40%) SNP at the FTO locus (rs9939609) that is associated with early onset obesity and increased food intake in experimental settings ..
  8. DIANE IHN AE GILBERT-DIAMOND; Fiscal Year: 2014
    ..during the 10-minute snacking period and the main exposures will be the child's genotype for the fat mass and obesity associated (FTO) gene rs9939609 allele as well as the exposure to food vs. toy advertisements...
  9. Paul T Williams; Fiscal Year: 2014
    ..g., the weaker effect of FTO polymorphisms on body mass index (BMI) in exercisers compared to non-exercisers...
  10. Rudolph L Leibel; Fiscal Year: 2016
    ..Aim 2 will use mice to address the molecular physiology of a recently discovered pair of adjacent genes (FTO/FTM) - and a related transcription factor, CUTL1 - strongly implicated in obesity by three GWAS;and a gene (MGRN1=..
  11. Functional imaging and eating behavior among FTO genotypes in pre-obese children
    Michael Rosenbaum; Fiscal Year: 2012
    ..An extremely common (allelic frequency of ~40%) SNP at the FTO locus (rs9939609) that is associated with early onset obesity and increased food intake in experimental settings ..
  12. Arthur W Toga; Fiscal Year: 2016
    ..brain-derived neurotrophic factor (BDNF), catechol-O-methyltransferase (COMT), and fat mass and obesity-associated (FTO) polymorphisms on gray and white matter shapes, and (4) genome-wide association studies (GWAS) to identify new ..
  13. Sonia Caprio; Fiscal Year: 2014
    ..The specific aims are: Aim 1: A) To examine the relationships between a panel of 16 gene variants (TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, HHEX, CDC123/CAMK1D, WFS1, TSPAN8/LGR5, THADA, ADAMTS9) and ..
  14. Samie R Jaffrey; Fiscal Year: 2016
    ..of m6A sites in the midbrain transcriptome for analysis and mutagenesis in Aims 2 and 3;(2) To determine how FTO affects the translation of its target mRNAs...
  15. IMMORTALIZATION OF SALIVARY GLAND EPITHELIAL CELL LINES
    JANICE MORAND; Fiscal Year: 1993
    ..Rat parotid and submandibular gland cells will be fused to rat hepatoma (FTO-2B) cells using polyethylene glycol...
  16. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2010
    ..abstract_text> ..
  17. Long-Term Exercise Maintenance via Internet Support
    Paul Williams; Fiscal Year: 2006
    ..We estimate that we will be able to detect differences in exercise cessation rates between the intervention and control group of 0.45% in runners and walkers separately (alpha=0.05, 80% statistical power). ..
  18. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2007
    ..These data could ultimately lead to more efficient use of physical activity and body weight control in the primary and secondary prevention of hypertension. ..
  19. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2007
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  20. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2002
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..
  21. The Family Blood Pressure Program (HyperGEN Network)
    Steven Hunt; Fiscal Year: 2007
    ..unreadable] (End of Abstract) [unreadable] [unreadable]..
  22. MULTIPLE SEVERE OBESITY RISK GENES IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2009
    ..Validation will be tested in a large case/control series, Polynesian families, and, for chromosome 20, in the congenic mouse model. ..
  23. GENETIC EPIDEMIOLOGY OF AGING IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2007
    ..This collection of longitudinally followed pedigrees provides a powerful study design to address a wide range of genetic epidemiological analyses of aging. ..
  24. GENCAC - Utah Field Center
    Steven Hunt; Fiscal Year: 2004
    ..abstract_text> ..
  25. Genotypes, Haplotypes, and Blood Pressure Change from Childhood to Adulthood
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ....
  26. Choline Tracers for Imaging of Cancer
    Timothy DeGrado; Fiscal Year: 2007
    ..abstract_text> ..
  27. Genes, Hormomes, Growth, and Body Fat: Project HeartBeat
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ..Our analyses may also help identify genetic variants that may predispose some individuals toward obesity. ..
  28. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
    ..The study results are highly relevant for identifying health care needs, improving care practices and developing strategies to prevent cleft lip and palate and/or reduce its associated adverse effects. ..
  29. APO E GENOTYPE AND HDL CHANGES WITH EXERCISE TRAINING
    JAMES HAGBERG; Fiscal Year: 2002
    ..Conversely, identifying persons who will improve their lipoprotein lipids the least with exercise training would allow them to focus on interventions that might be more efficacious for them. ..
  30. FOLDING AND CATALYSIS OF THE RIBOZYME FROM RNASE P
    Tao Pan; Fiscal Year: 2002
    ..These results will reveal how to stabilize a complex RNA structure, how to employ multiple domains to improve RNA catalysis and how to isolate ribozymes that can cleave any RNA structure or an RNA-protein complex. ..
  31. CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
    SANDRA HASSTEDT; Fiscal Year: 2002
    ..Identifying a gene that when mutated increases the risk of COPD may increase understanding of pulmonary function, as well as allowing gene-carriers to be identified and made aware of their susceptibility. ..
  32. PET TRACERS FOR MYOCARDIAL FATTY ACID OXIDATION
    Timothy DeGrado; Fiscal Year: 2003
    ..acid (FTP), and the oleate analog, 1 8-[F- 1 8]fluoro-4-thia-9Z-octadecenoic acid (FTO), in isolated rat heart...
  33. ACE GENOTYPE, BP, AND EXERCISE TRAINING IN HYPERTENSIVES
    JAMES HAGBERG; Fiscal Year: 2004
    ..abstract_text> ..
  34. Studies of RNA modifications on the genomic scale
    Tao Pan; Fiscal Year: 2006
    ..These measurements shall reveal the coordination of all modifications at the genomic level and their combinatorial effects on an essential function of tRNA. ..
  35. Genetic variations in calcium and vitamin D related gen*
    Ulrike Peters; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  36. KINETIC/THERMODYNAMIC/STRUCTURAL STUDIES OF RNA FOLDING
    Tao Pan; Fiscal Year: 2007
    ..This broad research program will reveal the structural basis of RNA folding, and the evolutionary and mechanistic link between RNA folding and RNA polymerase. ..
  37. Selenium genetic variation in selenoenzymes and prostate cancer
    Ulrike Peters; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  38. Effects of oral clefts on birth outcomes and cleft risks due to maternal smoking
    GEORGE WEHBY; Fiscal Year: 2008
    ..Another aim is to obtain consistent estimates of the effect of maternal smoking or cleft lip and palate risk. The proposed model can be applied to study other newborn disorders. [unreadable] [unreadable] [unreadable]..
  39. MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASE
    SANDRA HASSTEDT; Fiscal Year: 2009
    ..In addition, this application proposes to implement changes to increase computational speed, allow data exploration, and facilitate data handling and analysis, while continuing to distribute and support PAP. ..
  40. Maternal overnutrition and offspring fat mass, metabolic and vascular function.
    Debbie Lawlor; Fiscal Year: 2009
    ....
  41. GENETIC EPIDEMIOLOGY OF CHANGE IN CVD RISK FACTORS
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ....
  42. GENETIC STUDIES OF OBESITY
    R Price; Fiscal Year: 2008
    ..The identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. [unreadable] [unreadable]..
  43. Pilot for a Multicenter Case-Control Study of Pancreatic Cancer in a High Risk r*
    Paul Brennan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  44. Multicentric Pooled Analysis of Second Primary Cancer
    Paul Brennan; Fiscal Year: 2004
    ..g., ultraviolet light); (ii) an investigation of rare cancer types (e.g., bone cancer or sarcomas); and (iii) an investigation of second primary cancers which may be increased due to treatment of a first primary cancer (e.g., leukemia). ..
  45. The Genetics of Infant Growth and Later Obesity
    Ellen W Demerath; Fiscal Year: 2010
    ....
  46. International Lung Cancer Consortium: Pooled analysis o*
    Paul Brennan; Fiscal Year: 2006
    ..abstract_text> ..
  47. FINE LOCALIZATION OF GENES FOR HUMAN OBESITY
    R Price; Fiscal Year: 2004
    ..They further note that the identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. ..