Genomes and Genes
Gene Symbol: FTO
Description: fat mass and obesity associated
Alias: ALKBH9, AlkB homolog 9, alpha-ketoglutarate-dependent dioxygenase FTO, fat mass and obesity-associated protein, protein fto
Publications246 found, 100 shown here
- A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesityTimothy M Frayling
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
Science 316:889-94. 2007..A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI)...
- FTO gene polymorphisms and obesity risk: a meta-analysisSihua Peng
Department of Pathology, Zhejiang University School of Medicine, Hangzhou, PR China
BMC Med 9:71. 2011The pathogenesis of obesity is reportedly related to variations in the fat mass and an obesity-associated gene (FTO); however, as the number of reports increases, particularly with respect to varying ethnicities, there is a need to ..
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulationCristen J Willer
Genetic Investigation of ANthropometric Traits Consortium
Nat Genet 41:25-34. 2009Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans...
- Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South AsiansH Li
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
Diabetologia 55:981-95. 2012b>FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent...
- Life course variations in the associations between FTO and MC4R gene variants and body sizeRebecca Hardy
MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
Hum Mol Genet 19:545-52. 2010..We genotyped variants in FTO (rs9939609) and near MC4R (rs17782313) in 1240 men and 1239 women born in 1946 and participating in the MRC ..
- Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traitsAngelo Scuteri
Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
PLoS Genet 3:e115. 2007..Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight...
- FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studiesJens K Hertel
Department of Clinical Medicine, University of Bergen, Bergen, Norway
Diabetes 60:1637-44. 2011b>FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span.
- Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groupsAndre Scherag
Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
PLoS Genet 6:e1000916. 2010..Apart from previously identified FTO, MC4R, and TMEM18, we detected two new loci for obesity: one in SDCCAG8 (serologically defined colon cancer antigen ..
- Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008..After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2...
- Variation in FTO contributes to childhood obesity and severe adult obesityChristian Dina
CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
Nat Genet 39:724-6. 2007We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12...
- The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseThomas Gerken
Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
Science 318:1469-72. 2007Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans...
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesityGudmar Thorleifsson
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:18-24. 2009..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
- Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditureJohn R Speakman
Division of Obesity and Metabolic Health, Rowett Research Institute, Aberdeen, Scotland, UK
Obesity (Silver Spring) 16:1961-5. 2008The FTO gene has significant polymorphic variation associated with obesity, but its function is unknown...
- Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO geneKarani S Vimaleswaran
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
Am J Clin Nutr 90:425-8. 2009Intronic variation in the FTO (fat mass and obesity-associated) gene has been unequivocally associated with increased body mass index (BMI; in kg/m(2)) and the risk of obesity in populations of different ethnicity.
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesEleftheria Zeggini
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Genet 40:638-45. 2008..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
- Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studiesShengxu Li
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
Am J Clin Nutr 91:184-90. 2010..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
- Physical activity and the association of common FTO gene variants with body mass index and obesityEvadnie Rampersaud
Department of Medicine, University of Maryland, Baltimore, USA
Arch Intern Med 168:1791-7. 2008Common FTO (fat mass and obesity associated) gene variants have recently been associated with body mass index (BMI) and obesity in several large studies...
- Fine mapping of the association with obesity at the FTO locus in African-derived populationsMohamed T Hassanein
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
Hum Mol Genet 19:2907-16. 2010..replicate and fine map in populations of predominantly African ancestry the association between variation at the FTO locus and body mass index (BMI) that is well established in populations of European ancestry...
- Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant riskDharambir K Sanghera
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
BMC Med Genet 9:59. 2008..expressed homeobox (HHEX; rs 1111875); transcription factor-7-like 2 (TCF7L2; rs 10885409); potassium inwardly rectifying channel subfamily J member 11(KCNJ11; rs 5219); and fat mass obesity-associated gene (FTO; rs 9939609)].
- The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysisKerstin Wahlen
Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
J Lipid Res 49:607-11. 2008We investigated the rs9939609 single nucleotide polymorphism of the FTO gene in relation to fat cell function and adipose tissue gene expression in 306 healthy women with a wide range in body mass index (18-53 kg/m(2))...
- FTO variants are associated with obesity in the Chinese and Malay populations in SingaporeJonathan T Tan
Center for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
Diabetes 57:2851-7. 2008Association between genetic variants at the FTO locus and obesity has been consistently observed in populations of European ancestry and inconsistently in non-Europeans...
- FTO genetic variation and association with obesity in West Africans and African AmericansAdebowale Adeyemo
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
Diabetes 59:1549-54. 2010The FTO gene is one of the most consistently replicated loci for obesity. However, data from populations of African ancestry are limited...
- Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and developmentUlla Sovio
Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom
PLoS Genet 7:e1001307. 2011An age-dependent association between variation at the FTO locus and BMI in children has been suggested...
- Prevalence of loss-of-function FTO mutations in lean and obese individualsDavid Meyre
CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
Diabetes 59:311-8. 2010Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass- and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(-/-) mice are lean and Fto(+/-) mice are resistant to diet-induced obesity...
- FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysisBo Xi
Graduate School, Peking Union Medical College, Beijing 100730, China
Biomed Environ Sci 22:449-57. 2009..To clarify the contradictory findings in patients with obesity and type 2 diabetes by meta-analysis...
- FTO and MC4R gene variants are associated with obesity in polycystic ovary syndromeKathryn G Ewens
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e16390. 2011..While not associated with PCOS itself, five SNPs in FTO and two in MC4R were associated with BMI as assessed with a quantitative-TDT analysis, several of which replicated ..
- Common variants of FTO and the risk of obesity and type 2 diabetes in IndiansGanesh Chauhan
Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology CSIR, Delhi, India
J Hum Genet 56:720-6. 2011Common variants of fat mass and obesity-associated gene (FTO, fat mass- and obesity-associated gene) have been shown to be associated with obesity and type 2 diabetes in population of European and non-European ethnicity...
- A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variantsLaura J Scott
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
Science 316:1341-5. 2007..genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk...
- Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) CohortAmanda F Marvelle
Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Diabetes 57:1987-91. 2008..The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort...
- Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA StudyVanessa Legry
INSERM, U744, Lille, France
Metabolism 58:971-5. 2009We investigated the association between the rs9939609 (T>A) polymorphism in the FTO (fat mass- and obesity-associated) gene and obesity- and type 2 diabetes mellitus-related phenotypes in the French Multinational MONItoring of Trends ..
- Common body mass index-associated variants confer risk of extreme obesityChris Cotsapas
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Hum Mol Genet 18:3502-7. 2009..We found convincing association to the previously described locus including the FTO gene...
- Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 AsiansMaggie C Y Ng
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Diabetes 57:2226-33. 2008..However, the implications of these genes in Asians are unclear...
- PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese populationCheng Hu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
PLoS ONE 4:e7643. 2009..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
- The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, ChinaBo Xi
Department of Epidemiology, Capital Institute of Pediatrics, 2 Ya Bao Road, 100020 Beijing China
BMC Med Genet 11:107. 2010..susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European children and adults...
- A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyApril J Ho
Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:8404-9. 2010A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried by 46% of Western Europeans and is associated with an approximately 1...
- FTO gene variation and measures of body mass in an African populationBranwen J Hennig
MRC International Nutrition Group, NPHIRU, EPH, London School of Hygiene and Tropical Medicine, London, UK
BMC Med Genet 10:21. 2009Variation in the fat mass and obesity associated (FTO) gene has been reproducibly associated with body mass index (BMI) and obesity in populations of White European origin. Data from Asians and African-Americans is less conclusive.
- Replication and extension of genome-wide association study results for obesity in 4923 adults from northern SwedenFrida Renstrom
Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
Hum Mol Genet 18:1489-96. 2009Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...
- Crystal structure of the FTO protein reveals basis for its substrate specificityZhifu Han
National Institute of Biological Sciences, No 7 Science Park Road, Beijing 102206, China
Nature 464:1205-9. 2010Recent studies have unequivocally associated the fat mass and obesity-associated (FTO) gene with the risk of obesity...
- Regulation of Fto/Ftm gene expression in mice and humansGeorge Stratigopoulos
Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
Am J Physiol Regul Integr Comp Physiol 294:R1185-96. 2008..studies (GWAS) in European populations have associated a approximately 47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear...
- Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTOMarcel den Hoed
Department of Human Biology, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 90:1426-32. 2009The common rs9939609 single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is associated with adiposity, possibly by affecting satiety responsiveness.
- Clinical risk factors, DNA variants, and the development of type 2 diabetesValeriya Lyssenko
Department of Clinical Sciences, Lund University, Malmo, Sweden
N Engl J Med 359:2220-32. 2008..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
- Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004Mika Kivimaki
Department of Epidemiology and Public Health, Faculty of Biomedical Sciences, University College London, United Kingdom
Am J Epidemiol 173:421-9. 2011..obesity and common mental disorders (CMD) by utilizing the known relation between fat mass and obesity-associated (FTO) genotype and body mass index (BMI; weight (kg)/height (m)(2))...
- FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-AmericansNora L Nock
Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106 7281, USA
Carcinogenesis 32:748-56. 2011..Polymorphisms in the fat-mass and obesity-associated (FTO) gene have been associated with BMI and larger effects in older versus younger children have been reported...
- Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populationsWei Huang
Division of Endocrinology, Department of Puren Hospital, Wuhan University of Science and Technology, Wuhan, China
Endocrine 39:69-74. 2011Genetic variants of FTO and MC4R have been linked with obesity and T2DM in populations of Europeans...
- β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individualsMette Thomsen
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
J Clin Endocrinol Metab 97:E1074-9. 2012..The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes...
- Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79)Kandaswamy Ramya
Madras Diabetes Research Foundation, ICMR Advanced Centre for Genomics of Type 2 Diabetes and Dr Mohan s Diabetes Specialities Centre, Gopalapuram, Chennai, India
Diabetes Technol Ther 13:33-42. 2011..and rs1588413 (in intron 8), and rs11076023 (3' untranslated region)-across three regulatory regions of the fat mass and obesity-associated (FTO) gene with obesity and type 2 diabetes mellitus (T2DM) in a South Indian population.
- Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youthGaifen Liu
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, The Netherlands
Eur J Epidemiol 26:463-73. 2011Recent genome-wide association (GWA) studies identified several common variants for obesity: rs9939609 in FTO, rs7566605 near INSIG2 and both rs17782313 and rs17700633 near the MC4R gene...
- Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes riskHana Lango
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Diabetes 57:3129-35. 2008..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
- FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatnessSofia I I Kring
Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
PLoS ONE 3:e2958. 2008A common single nucleotide polymorphism (SNP) of FTO (rs9939609, T/A) is associated with total body fatness...
- Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based studyMandy van Hoek
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Diabetes 57:3122-8. 2008..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
- Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modelingMarika Kaakinen
Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland
Am J Epidemiol 172:653-65. 2010The association between variation in the fat mass and obesity-associated (FTO) gene and adulthood body mass index (BMI; weight (kg)/height (m)(2)) is well-replicated...
- Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulationCamilla H Andreasen
Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
Diabetes 57:95-101. 2008Three independent studies have shown that variation in the fat mass and obesity-associated (FTO) gene associates with BMI and obesity...
- The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeksAbel Lopez-Bermejo
Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, 17007 Girona, Spain
J Clin Endocrinol Metab 93:1501-5. 2008Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single-nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates.
- FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunctionAmélie Bravard
INSERM, IFR, Oullins, France
Diabetes 60:258-68. 2011A strong association between genetic variants and obesity was found for the fat mass and obesity-associated gene (FTO)...
- A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French CanadiansZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Circ Cardiovasc Genet 2:260-9. 2009b>FTO is the first gene established as contributing to common forms of obesity. The gene is highly expressed in the hypothalamus and is thought to mediate this effect through its influence on energy homeostasis...
- FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent malesRobert A Scott
Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Eur J Hum Genet 18:1339-43. 2010Studies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk...
- Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) StudyEryn T Liem
Department of Pediatrics Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Am J Clin Nutr 91:321-8. 2010..Overweight is a complex trait in which both environmental and genetic factors play a role...
- Association of FTO gene variants with adiposity in African-American adolescentsSureka Bollepalli
Division of Endocrinology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
Obesity (Silver Spring) 18:1959-63. 2010..Specifically, variants of the fat mass and obesity associated (FTO) gene have been associated with obesity in populations of European descent...
- Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese populationShigeru Karasawa
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Endocr J 57:293-301. 2010The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 +/- 10.2 years), a Japanese community-based study...
- The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924Josefin A Jacobsson
Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
BMC Med Genet 10:131. 2009Common FTO (fat mass and obesity associated) gene variants have recently been strongly associated with body mass index and obesity in several large studies...
- The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention StudyTiina J Lappalainen
School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
Obesity (Silver Spring) 17:832-6. 2009The common single-nucleotide polymorphism in the FTO (fat mass and obesity associated) gene is consistently associated with an increased risk of obesity...
- Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus StudyX Lin
Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
Diabetologia 52:600-8. 2009....
- The fat mass- and obesity-associated locus and dietary intake in childrenNicholas J Timpson
MRC CAiTE Centre, Department of Social Medicine, Bristol University, Bristol, UK
Am J Clin Nutr 88:971-8. 2008A region of chromosome 16 containing the fat mass-and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity.
- Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesityEmily Sonestedt
Department of Clinical Sciences in Malmo, Nutrition Epidemiology, Lund University, Malmo, Sweden
Am J Clin Nutr 90:1418-25. 2009The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation.
- An obesity-associated FTO gene variant and increased energy intake in childrenJoanne E Cecil
Bute Medical School, University of St Andrews, St Andrews, United Kingdom
N Engl J Med 359:2558-66. 2008Variation in the fat mass and obesity-associated (FTO) gene has provided the most robust associations with common obesity to date. However, the role of FTO variants in modulating specific components of energy balance is unknown.
- The FTO gene rs9939609 obesity-risk allele and loss of control over eatingMarian Tanofsky-Kraff
Unit on Growth and Obesity, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
Am J Clin Nutr 90:1483-8. 2009Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT).
- Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese populationYi Cheng Chang
Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
Diabetes 57:2245-52. 2008Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations...
- Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMIRachel M Freathy
Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
Diabetes 57:1419-26. 2008Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides...
- rs9939609 in the FTO gene is associated with obesity but not with several biochemical parameters in Sardinian obese childrenPatrizia Zavattari
Servizio di Endocrinologia Pediatrica, Ospedale Microcitemico ASL Cagliari, Italy
Ann Hum Genet 75:648-54. 2011..association of the intronic single nucleotide polymorphism (SNP) rs9939609 of the fat mass and obesity-associated (FTO) gene with obesity and with a number of obesity-related features...
- Evaluation of genetic susceptibility loci for obesity in Chinese womenJiajun Shi
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Epidemiol 172:244-54. 2010..Two SNPs near the BAT2 and MC4R genes and 3 SNPs within the FTO, SEC16B, and SH2B1 genes were significantly associated with body mass index (weight (kg)/height (m)(2)), body ..
- The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescentsD M Hallman
Human Genetics Center, University of Texas School of Public Health, Houston, TX 77225, USA
Int J Obes (Lond) 36:61-8. 2012To investigate possible age-related changes in associations between polymorphisms in the fat mass and obesity-associated (FTO) gene and higher body mass index (BMI).
- The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) studyAlex S F Doney
Diabetes Research Group, Biomedical Research Institute, University of Dundee, Dundee, United Kingdom
Circ Cardiovasc Genet 2:255-9. 2009Common variation in the fat mass and obesity (FTO)-related gene is associated with increased body fat and susceptibility to type 2 diabetes...
- High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adultsCatherine M Phillips
Nutrigenomics Research Group, University College Dublin School of Public Health and Population Science, University College Dublin Conway Institute, Dublin, Ireland
J Nutr 142:824-31. 2012Fat mass and obesity-associated (FTO) is the strongest genetic determinant of obesity identified to date. Dietary fat is a key environmental factor that may interact with genotype to affect risk of obesity and metabolic syndrome (MetS)...
- Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependenceAgnieszka Sobczyk-Kopciol
Department of General Biology and Parasitology, Medical University of Warsaw, Poland
Addiction 106:739-48. 2011To investigate whether the FTO rs9939609 A allele (a risk factor for obesity) is associated with measures of alcohol consumption.
- The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white womenTariq Ahmad
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Am Heart J 160:1163-9. 2010Variation in the Fat-Mass and Obesity-Associated (FTO) gene has been associated with obesity, diabetes, and hypertension...
- FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal womenYiqing Song
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Obesity (Silver Spring) 16:2472-80. 2008The FTO gene was recently identified as a susceptibility locus for both obesity and type 2 diabetes by whole-genome association analyses of several European populations...
- Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of PolynesiaRebekah Karns
Department of Environmental Health, University of Cincinnati College of Medicine, OH, USA
Ann Hum Genet 76:17-24. 2012The association between obesity and the fat mass and obesity-associated (FTO) gene has been widely replicated among Caucasian populations...
- Genome wide analysis reveals association of a FTO gene variant with epigenetic changesMarkus Sällman Almén
Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala, Sweden
Genomics 99:132-7. 2012Variants of the FTO gene show strong association with obesity, but the mechanisms behind this association remain unclear. We determined the genome wide DNA methylation profile in blood from 47 female preadolescents...
- Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese womenQun Yan
Shanghai Key Laboratory for Endocrine Tumors, Shanghai Institute of Endocrine and metabolic Disease, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Lu, 200025 Shanghai, People s Republic of China
Endocrine 36:377-82. 2009Variations in the fat mass and obesity-associated (FTO) gene have recently been associated with obesity and type 2 diabetes mellitus among different ethnic populations...
- Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in KoreansHye Ja Lee
Division of Metabolic Disease, Center for Biomedical Sciences, National Institute of Health, 194 Tongillo, Eunpyung Gu, Seoul 122 701, Republic of Korea
Clin Chim Acta 411:1716-22. 2010Associations with FTO (fat mass and obesity associated) gene variants and BMI have been reported in western adult populations...
- The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly menChristian Benedict
Department of Neuroscience, Uppsala University, Uppsala, Sweden
Neurobiol Aging 32:1159.e1-5. 2011Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries...
- Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese populationKikuko Hotta
EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Hum Genet 56:647-51. 2011..are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1...
- The role of the fat mass and obesity associated gene (FTO) in breast cancer riskVirginia Kaklamani
Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine and Robert H, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 676 N St Clair st suite 850, Chicago, IL 60611, USA
BMC Med Genet 12:52. 2011Obesity has been shown to increase breast cancer risk. FTO is a novel gene which has been identified through genome wide association studies (GWAS) to be related to obesity...
- A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMIDolores Corella
Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 141:2219-25. 2011Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce...
- Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese populationKikuko Hotta
Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Japan
J Hum Genet 55:738-42. 2010..methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes...
- Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC studyJan Bressler
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 5:e10521. 2010Single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene are associated with body mass index (BMI) in populations of European descent...
- Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA studyJonatan R Ruiz
Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Huddinge, Sweden
Arch Pediatr Adolesc Med 164:328-33. 2010To examine whether physical activity attenuates the effect of the FTO rs9939609 polymorphism on body fat estimates in adolescents.
- Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish menEsther Zimmermann
Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
PLoS ONE 4:e4428. 2009The A-allele of the single nucleotide polymorphism (SNP), rs9939609, in the FTO gene is associated with increased fatness. We hypothesized that the SNP is associated with morbidity and mortality through the effect on fatness.
- Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. womenTariq Ahmad
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Diabetes Care 34:675-80. 2011Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains unclear.
- Variations in the FTO gene are associated with severe obesity in the JapaneseKikuko Hotta
Laboratory for Obesity, SNP Research Center, RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
J Hum Genet 53:546-53. 2008Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese...
- 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescentsTimo D Müller
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
BMC Med Genet 9:85. 2008We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this ..
- Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levelsEva Fisher
Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
Obesity (Silver Spring) 17:330-4. 2009..Variation at the fat-mass and obesity-associated (FTO) gene locus has been reported to be associated with increased body fat...
- Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern FranceR Attaoua
IURC, Molecular Endocrinology Laboratory UMR 204, Montpellier Cedex 5, France
Diabetes Metab 35:476-83. 2009The objective of the present study was to investigate the genetic association of the fat-mass-and-obesity-associated (FTO) gene in obese women in the presence of the known influential role of the insulin receptor substrate 2 (IRS-2) gene.
- Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO)Michael Linnebacher
Department of General, Thoracic, Vascular and Transplant Surgery, University of Rostock, Rostock, Germany
J Biomed Biotechnol 2010:841451. 2010..Here, we provide conclusive data that the (-1) frame of U79260(FTO) encodes an HLA-A0201-restricted cytotoxic T cell epitope (FSP11; TLSPGWSAV)...
- Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preferenceFlorianne Bauer
Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
Am J Clin Nutr 90:951-9. 2009..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
- Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndromeElisabeth Wehr
Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University Graz, A 8036 Graz, Austria
Metabolism 59:575-80. 2010Variants in the fat mass and obesity-associated gene (FTO) are associated with obesity and type 2 diabetes mellitus. Women with polycystic ovary syndrome (PCOS) are frequently affected by obesity and impaired glucose tolerance...
- Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adultsA Jonsson
Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
Diabetologia 52:1334-8. 2009Recent reports have suggested that genotypes at the FTO locus interact with physical activity to modify levels of obesity-related traits...
- Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndromeT M Barber
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK
Diabetologia 51:1153-8. 2008Variants in the fat-mass and obesity-associated gene (FTO) influence susceptibility to type 2 diabetes via an effect on adiposity/obesity...
- Variant rs9939609 in the FTO gene is associated with obesity in an adult population from SpainJosé L González-Sánchez
Department of Internal Medicine II, Hospital Clinico San Carlos, Madrid, Spain
Clin Endocrinol (Oxf) 70:390-3. 2009Recently independent studies, including genome-wide scans, have shown that variation in the fat mass and obesity associated gene (FTO) were significantly associated with obesity in populations of European origin.
- Variation in the FTO gene influences food intake but not energy expenditureA Haupt
Department of Internal Medicine, Division of Diabetology, Endocrinology, Nephrology and Angiology, Clinical Chemistry, University of Tubingen, Tubingen, Germany
Exp Clin Endocrinol Diabetes 117:194-7. 2009Polymorphisms in the FTO (fat mass- and obesity-associated) gene are associated with obesity. The mechanisms how genetic variation in this gene influences body weight are unknown...
- Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in GermanyAnke Tonjes
Department of Medicine, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
Eur J Hum Genet 18:104-10. 2010The association between common variants in the FTO gene with weight, adiposity and body mass index (BMI) has now been widely replicated...
- IMMORTALIZATION OF SALIVARY GLAND EPITHELIAL CELL LINESJANICE MORAND; Fiscal Year: 1993..Rat parotid and submandibular gland cells will be fused to rat hepatoma (FTO-2B) cells using polyethylene glycol...
- PET TRACERS FOR MYOCARDIAL FATTY ACID OXIDATIONTimothy DeGrado; Fiscal Year: 2003..acid (FTP), and the oleate analog, 1 8-[F- 1 8]fluoro-4-thia-9Z-octadecenoic acid (FTO), in isolated rat heart...
- Functional imaging and eating behavior among FTO genotypes in pre-obese childrenMichael Rosenbaum; Fiscal Year: 2012..An extremely common (allelic frequency of ~40%) SNP at the FTO locus (rs9939609) that is associated with early onset obesity and increased food intake in experimental settings ..
- GENCAC - Utah Field CenterSteven Hunt; Fiscal Year: 2004..abstract_text> ..
- GENETIC EPIDEMIOLOGY OF AGING IN UTAH PEDIGREESSteven Hunt; Fiscal Year: 2007..This collection of longitudinally followed pedigrees provides a powerful study design to address a wide range of genetic epidemiological analyses of aging. ..
- The Family Blood Pressure Program (HyperGEN Network)Steven Hunt; Fiscal Year: 2007..unreadable] (End of Abstract) [unreadable] [unreadable]..
- MULTIPLE SEVERE OBESITY RISK GENES IN UTAH PEDIGREESSteven Hunt; Fiscal Year: 2009..Validation will be tested in a large case/control series, Polynesian families, and, for chromosome 20, in the congenic mouse model. ..
- Maternal overnutrition and offspring fat mass, metabolic and vascular function.Debbie Lawlor; Fiscal Year: 2009....
- GENETIC EPIDEMIOLOGY OF CHANGE IN CVD RISK FACTORSDAVID MICHAEL HALLMAN; Fiscal Year: 2010....
- Multicentric Pooled Analysis of Second Primary CancerPaul Brennan; Fiscal Year: 2004..g., ultraviolet light); (ii) an investigation of rare cancer types (e.g., bone cancer or sarcomas); and (iii) an investigation of second primary cancers which may be increased due to treatment of a first primary cancer (e.g., leukemia). ..
- The Genetics of Infant Growth and Later ObesityEllen W Demerath; Fiscal Year: 2010....
- GENETIC STUDIES OF OBESITYR Price; Fiscal Year: 2008..The identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. [unreadable] [unreadable]..
- Pilot for a Multicenter Case-Control Study of Pancreatic Cancer in a High Risk r*Paul Brennan; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- FINE LOCALIZATION OF GENES FOR HUMAN OBESITYR Price; Fiscal Year: 2004..They further note that the identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. ..
- International Lung Cancer Consortium: Pooled analysis o*Paul Brennan; Fiscal Year: 2006..abstract_text> ..
- HERITAGE FAMILY STUDY, PHASE 4Tuomo Rankinen; Fiscal Year: 2010..abstract_text> ..