FOXP2

Summary

Gene Symbol: FOXP2
Description: forkhead box P2
Alias: CAGH44, SPCH1, TNRC10, forkhead box protein P2, CAG repeat protein 44, forkhead/winged-helix transcription factor, trinucleotide repeat containing 10, trinucleotide repeat-containing gene 10 protein
Species: human

Top Publications

  1. ncbi cDNAs with long CAG trinucleotide repeats from human brain
    R L Margolis
    Laboratory of Molecular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Genet 100:114-22. 1997
  2. ncbi A forkhead-domain gene is mutated in a severe speech and language disorder
    C S Lai
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 413:519-23. 2001
  3. ncbi FOXP2: novel exons, splice variants, and CAG repeat length stability
    Heather A Bruce
    Laboratory of Genetic Neurobiology, Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Genet 111:136-44. 2002
  4. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
  5. pmc Accelerated protein evolution and origins of human-specific features: Foxp2 as an example
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 162:1825-35. 2002
  6. pmc Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
    Kay D Macdermot
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:1074-80. 2005
  7. ncbi Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations
    Julio Sanjuan
    Psychiatric Unit, Faculty of Medicine, Clinical Hospital, Valencia, Spain
    Psychiatr Genet 16:67-72. 2006
  8. pmc Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia
    Lars Feuk
    The Centre for Applied Genomics and Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 79:965-72. 2006
  9. pmc High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, The University of Oxford, Oxford, OX3 7BN, UK
    Am J Hum Genet 81:1232-50. 2007
  10. doi Multiple transcription start sites for FOXP2 with varying cellular specificities
    Diane I Schroeder
    Biomedical Informatics Program, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Gene 413:42-8. 2008

Research Grants

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
  2. Stephanie Ann White; Fiscal Year: 2016
  3. FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions
    Genevieve Konopka; Fiscal Year: 2010
  4. Bennett G Novitch; Fiscal Year: 2014
  5. Investigating the role of CNTNAP2 gene in vocal learning in mutant songbirds
    Carlos Lois; Fiscal Year: 2013
  6. Transfusion-associated immune hemolysis
    Karina Yazdanbakhsh; Fiscal Year: 2010
  7. JERALD MICHAEL BOWERS; Fiscal Year: 2014
  8. Transcriptional Regulation of Myogenic Stem Cells
    Daniel J Garry; Fiscal Year: 2013
  9. Sudha K Iyengar; Fiscal Year: 2016
  10. FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions
    Genevieve Konopka; Fiscal Year: 2013

Detail Information

Publications222 found, 100 shown here

  1. ncbi cDNAs with long CAG trinucleotide repeats from human brain
    R L Margolis
    Laboratory of Molecular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Genet 100:114-22. 1997
    ..These genes are therefore candidates for diseases featuring anticipation, neurodegeneration, or abnormalities of neurodevelopment...
  2. ncbi A forkhead-domain gene is mutated in a severe speech and language disorder
    C S Lai
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 413:519-23. 2001
    ..Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, ..
  3. ncbi FOXP2: novel exons, splice variants, and CAG repeat length stability
    Heather A Bruce
    Laboratory of Genetic Neurobiology, Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Genet 111:136-44. 2002
    ..2) with a breakpoint between exons 3b and 4 have recently been associated with a speech and language disorder (SPCH1)...
  4. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..b>FOXP2 is the first gene relevant to the human ability to develop language...
  5. pmc Accelerated protein evolution and origins of human-specific features: Foxp2 as an example
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 162:1825-35. 2002
    ..Using comparative analysis of human, chimpanzee, and mouse protein sequences, we identified two genes (PRM2 and FOXP2) with significantly enhanced evolutionary rates in the hominid lineage...
  6. pmc Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
    Kay D Macdermot
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:1074-80. 2005
    b>FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a unique entry point into neuromolecular mechanisms influencing human speech and language acquisition...
  7. ncbi Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations
    Julio Sanjuan
    Psychiatric Unit, Faculty of Medicine, Clinical Hospital, Valencia, Spain
    Psychiatr Genet 16:67-72. 2006
    A mutation in the FOXP2 gene has been the first genetic association with a language disorder. Language disorder is considered as a core symptom of schizophrenia...
  8. pmc Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia
    Lars Feuk
    The Centre for Applied Genomics and Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 79:965-72. 2006
    Mutations in FOXP2 cause developmental verbal dyspraxia (DVD), but only a few cases have been described...
  9. pmc High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, The University of Oxford, Oxford, OX3 7BN, UK
    Am J Hum Genet 81:1232-50. 2007
    We previously discovered that mutations of the human FOXP2 gene cause a monogenic communication disorder, primarily characterized by difficulties in learning to make coordinated sequences of articulatory gestures that underlie speech...
  10. doi Multiple transcription start sites for FOXP2 with varying cellular specificities
    Diane I Schroeder
    Biomedical Informatics Program, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Gene 413:42-8. 2008
    b>FOXP2 is a forkhead transcription factor implicated in developmental verbal dyspraxia, a human speech and language disorder. FOXP2 is expressed in complex patterns during brain, lung, heart, and gut development and on into adulthood...
  11. doi Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders
    Fabrice Laroche
    INSERM Avenir, Institut Jacques Monod UMR7592, Paris, France
    Psychiatr Genet 18:295-301. 2008
    ..Genetic studies have reported an association between autism and DLX2, HOXA1, EN2, ARX, and FOXP2 genes whereas only three studies of EN2, OTX2, and FOXP2 were performed on schizophrenia...
  12. doi A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Cell 137:961-71. 2009
    It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language...
  13. pmc A functional genetic link between distinct developmental language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    N Engl J Med 359:2337-45. 2008
    Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment.
  14. ncbi FOXP2 polymorphisms in patients with schizophrenia
    Julio Sanjuan
    Unidad de Psiquiatria, Facultad de Medicina, Hospital Clinico, Universitat de Valencia, Blasco Ibaez 15, 46010 Valencia, Spain
    Schizophr Res 73:253-6. 2005
    b>FOXP2 was described as the first gene involved in our ability to acquire spoken language...
  15. pmc Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain
    Elizabeth Spiteri
    Program in Neurogenetics, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 81:1144-57. 2007
    Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the only known cause of developmental speech and language disorders in humans...
  16. ncbi [Effect of apoptosis of CD4+ CD25+ regulatory T lymphocytes on polarization of helper T lymphocytes and potential interventional influence of Xuebijing injection in septic rats]
    Xin gui Dai
    Intensive Care Unit, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:135-8. 2009
    ..To evaluate the influence of apoptosis of CD4(+)CD25(+) regulatory T lymphocyte (Treg) on polarization of helper T lymphocyte (Th) and effect of Xuebijing injection in septic rats...
  17. ncbi [Evolution of human brain and intelligence]
    Laszlo Lakatos
    Pszichiátriai magánrendelés, Szekesfehervar
    Ideggyogy Sz 61:220-9. 2008
    ..The appearance and stabilisation of FOXP2 gene structure as feature of modern man coincided with the first presence and quick spread of Homo sapiens on the ..
  18. pmc Reconstructing phylogenies and phenotypes: a molecular view of human evolution
    Brenda J Bradley
    Department of Zoology and Christ s College, University of Cambridge, UK
    J Anat 212:337-53. 2008
    ..Loci involved in speech (e.g. FOXP2), brain development (e.g. ASPM), and skull musculature (e.g...
  19. pmc Alternative splicing and gene duplication in the evolution of the FoxP gene subfamily
    M Emilia Santos
    Departamento de Biologia Animal, Faculdade de Ciencias da Universidade de Lisboa, Lisboa, Portugal
    Mol Biol Evol 28:237-47. 2011
    ..Its four members, FoxP1-P4, have been extensively characterized functionally. FoxP1, FoxP2, and FoxP4 are involved in lung, heart, gut, and central nervous system (CNS) development...
  20. doi [Effects of Cordyceps extract on cytokines and transcription factors in peripheral blood mononuclear cells of asthmatic children during remission stage]
    Wen Sun
    Department of Traditional Chinese Medicine, Children s Hospital, Fudan University, Shanghai 201102, China
    Zhong Xi Yi Jie He Xue Bao 8:341-6. 2010
    ..To explore the effects of Cordyceps extract in regulating the imbalance of Th1/Th2 ratio and inhibiting the inflammatory reaction, and to find the theoretical basis of Cordyceps extract for treating asthma in remission stage...
  21. pmc Area postrema projects to FoxP2 neurons of the pre-locus coeruleus and parabrachial nuclei: brainstem sites implicated in sodium appetite regulation
    Matthew K Stein
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Res 1359:116-27. 2010
    ..Both pontine cell groups express the transcription factor FoxP2 and become c-Fos activated following sodium depletion...
  22. ncbi FoxP2 expression in avian vocal learners and non-learners
    Sebastian Haesler
    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    J Neurosci 24:3164-75. 2004
    ..b>FOXP2 is the first gene linked to human speech and has been the target of positive selection during recent primate ..
  23. pmc Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells
    Thirajit Boonsaen
    Department of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Biochem J 405:359-67. 2007
    ..2 kb promoter fragment. The results presented here show that Foxa2 and USFs regulate the distal promoter of the rat PC gene in a cell-specific manner...
  24. doi Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitis
    Maria Serena Longhi
    Institute of Liver Studies, King s College London School of Medicine at King s College Hospital, Denmark Hill, London, UK
    Hepatology 47:581-91. 2008
    ..Suppressor function and FOXP3 expression of both expanded and newly generated T-regs were higher in normal controls than in AIH patients...
  25. doi Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2
    Kaoru Takahashi
    Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Tokyo 194 8511, Japan
    J Comp Neurol 509:180-9. 2008
    ..By using the developing monkey brain as a model for human development, we investigated the expression pattern of the FOXP2 gene, a member of the FOX family of transcription factors in the developing monkey brain, and compared its ..
  26. doi Characterization of regulatory T cells in patients with dermatomyositis
    E Antiga
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    J Autoimmun 35:342-50. 2010
    ..05). These data suggest that the depletion of T(reg) and their main effector cytokines in the skin and the serum of patients with DM may be an important factor in the pathogenesis of the disease...
  27. ncbi Genetic components of vocal learning
    Constance Scharff
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Ann N Y Acad Sci 1016:325-47. 2004
    ..Special attention is given to a particular gene, FOXP2, which has been implicated in a human speech and language disorder...
  28. ncbi Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c
    Yifang Chen
    Department of Pathology, Immunology, and Laboratory Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 175:1080-9. 2005
    ....
  29. ncbi Induction of FoxP3+CD4+25+ regulatory T cells following hemopoietic stem cell transplantation: role of bone marrow-derived facilitating cells
    Kendra N Taylor
    Division of Thoracic Surgery, Department of Surgery Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 179:2153-62. 2007
    ..The transplantation of donor FC may provide an alternative approach to permit clinical SC engraftment and induction of transplantation tolerance in the future...
  30. doi Absence of amplification of CD4+CD25(high) regulatory T cells during in vitro expansion of tumor-infiltrating lymphocytes in melanoma patients
    Anne Chantal Knol
    INSERM, U601, 9 Quai Moncousu Nantes Cedex 01, France
    Exp Dermatol 17:436-45. 2008
    ..These cells were indeed Treg cells as they expressed Foxp3. In conclusion, our work suggests that CD4+CD25(high) Foxp3 expressing T cells are not expanded during in vitro amplification of TIL obtained from melanoma-invaded LNs...
  31. pmc Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells
    Eriko Fujita
    Divisions of Development and Differentiation, Department of Human Inherited Metabolic Disease, National Institute of Neuroscience, 4 1 1 Ogawahigashi machi, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 105:3117-22. 2008
    Previous studies have demonstrated that mutation in the forkhead domain of the forkhead box P2 (FOXP2) protein (R553H) causes speech-language disorders...
  32. doi The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortex
    T Hisaoka
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 166:551-63. 2010
    Foxp1 and Foxp2, which belong to the forkhead transcription factor family, are expressed in the developing and adult mouse brain, including the striatum, thalamus, and cerebral cortex...
  33. doi Knockdown of FoxP2 alters spine density in Area X of the zebra finch
    S B Schulz
    Freie Universitat Berlin, Laboratory of Animal Behavior, Berlin, Germany
    Genes Brain Behav 9:732-40. 2010
    Mutations in the gene encoding the transcription factor FoxP2 impair human speech and language...
  34. pmc FoxP2 regulation during undirected singing in adult songbirds
    Ikuko Teramitsu
    Interdepartmental Programs in Molecular, Cellular, and Integrative Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 26:7390-4. 2006
    ..To date, FOXP2 (forkhead box P2), a transcriptional repressor, is the only molecule directly linked to human speech...
  35. pmc Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Eur J Hum Genet 17:1354-8. 2009
    ..One exception is the identification of rare heterozygous mutations of the FOXP2 gene in a monogenic syndrome characterised by impaired sequencing of articulatory gestures, disrupting speech (..
  36. pmc Song practice promotes acute vocal variability at a key stage of sensorimotor learning
    Julie E Miller
    Department of Physiological Science, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e8592. 2010
    ..In juvenile and adult male zebra finches, endogenous levels of FoxP2, a molecule critical for language, decrease two hours after morning song onset within area X, part of the basal ..
  37. doi The potential effect and mechanism of high-mobility group box 1 protein on regulatory T cell-mediated immunosuppression
    Ying Zhang
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to Chinese PLA General Hospital, Beijing, People s Republic of China
    J Interferon Cytokine Res 31:249-57. 2011
    ..HMGB1 appears to be involved in modulating cell-mediated immunity by influencing proliferation of effector T cells, secretion of IL-2, and cell polarization...
  38. ncbi Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype
    T Schlake
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg, Germany
    Dev Dyn 217:368-76. 2000
    ..Our results implicate Whn as a transcriptional regulator of hair keratin genes and reveal the nude phenotype as the first example of an inherited skin disorder that is caused by loss of expression rather than mutation of keratin genes...
  39. ncbi Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells
    Mark Christian
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Biol Chem 277:20825-32. 2002
    ..These results provide the first evidence of regulated expression of FKHR and demonstrate that FKHR has an integral role in PKA-dependent endometrial differentiation through its ability to bind and functionally cooperate with C/EBPbeta...
  40. ncbi Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP
    Maria K Dahle
    Department of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
    J Biol Chem 277:22902-8. 2002
    ..In summary, winged helix transcription factors of the FOXC/FOXD families function as regulators of the RI alpha subunit of PKA and may integrate hormonal signals acting through protein kinase B and cAMP in a cell-specific manner...
  41. ncbi [The aetiopathogenesis of auditory hallucinations in psychosis]
    J Sanjuan
    Unidad de Psiquiatria, Facultad de Medicina Universidad de Valencia, 46010 Valencia, Espana
    Rev Neurol 43:280-6. 2006
    ..Neither of these approaches are listening to each other. Neither of them look at the molecular genetic vulnerability to auditory hallucinations in psychosis...
  42. doi Expression of Foxp4 in the developing and adult rat forebrain
    Kaoru Takahashi
    Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan
    J Neurosci Res 86:3106-16. 2008
    ..the expression pattern of Foxp4, a member of the Foxp subfamily, and compared its pattern with the patterns of Foxp2 and Foxp1 in the developing rat brain...
  43. ncbi [Significance of CD4+ CD25+ CD127(low) regulatory T cells and notch1 pathway in the pathogenesis of aplastic anemia]
    Xiao Xiao Yin
    Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, China
    Zhonghua Xue Ye Xue Za Zhi 29:308-11. 2008
    ....
  44. pmc Conservation and diversity of Foxp2 expression in muroid rodents: functional implications
    Polly Campbell
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    J Comp Neurol 512:84-100. 2009
    b>FOXP2, the first gene causally linked to a human language disorder, is implicated in song acquisition, production, and perception in oscine songbirds, the evolution of speech and language in hominids, and the evolution of echolocation in ..
  45. doi The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation
    Pedro Farinha
    Pathology and Laboratory Medicine, BC Cancer Agency Center for Lymphoid Cancers, Vancouver, BC, Canada
    Blood 115:289-95. 2010
    ..008 and P < .001, respectively), while only FOXP3(+) pattern predicted RT (P = .004). We conclude that FOXP3(+) cell distribution significantly predicts survival and RT in FL...
  46. ncbi The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development
    Deidre Mattiske
    Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC 27710, USA
    Dev Biol 290:447-58. 2006
    ..We conclude that alongside its previously known roles in kidney, cardiovascular and eye development, Foxc1 has essential functions during at least two stages of gonad development-germ cell migration and folliculogenesis...
  47. ncbi De-novo balanced translocation between 7q31 and 10p14 in a girl with central precocious puberty, moderate mental retardation, and severe speech impairment
    Tomoki Kosho
    Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Dysmorphol 17:31-4. 2008
    No causative gene has been found for idiopathic central precocious puberty; and FOXP2, located in 7q31, is the only known gene for speech and language disturbances...
  48. pmc Cre fate mapping reveals lineage specific defects in neuronal migration with loss of Pitx2 function in the developing mouse hypothalamus and subthalamic nucleus
    Jennifer M Skidmore
    Department of Pediatrics, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Mol Cell Neurosci 37:696-707. 2008
    ..arrested in Pitx2(cre/null) embryos, and subclasses of subthalamic nucleus neurons identified by Lmx1b, Foxp1, and Foxp2-gene expression revealed differing sensitivities to Pitx2 dosage...
  49. doi Mycobacterium bovis bacillus Calmette-Guérin killed by extended freeze-drying targets plasmacytoid dendritic cells to regulate lung inflammation
    Micheline Lagranderie
    Laboratoire d Immunothérapie, Institut Pasteur, Paris, France
    J Immunol 184:1062-70. 2010
    ..EFD BCG reduced allergic inflammation by recruiting pDCs that promoted Tregs; EFD BCG acted as a peroxisome proliferator-activated receptor gamma agonist and thus could be used in asthma and other inflammatory diseases...
  50. pmc Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    Estelle Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:5138-43. 2005
    ..Here, we show that, among the Foxp transcriptional factor family, which includes Foxp1, Foxp2, and Foxp3, only Foxp3 has the ability to inhibit IL-2, IL-4, and IFN-gamma production by primary T helper cells...
  51. ncbi A model of early molecular regionalization in the chicken embryonic pretectum
    J L Ferran
    Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain
    J Comp Neurol 505:379-403. 2007
    ..We examined in detail Pax3, Pax6, Pax7, Tcf4, Meis1, Meis2, Nkx2.2, Lim1, Dmbx1, Dbx1, Six3, FoxP2, Zic1, Ebf1, and Shh mRNA expression, as well as PAX3 and PAX7 immunoreaction, between stages HH11 and HH28...
  52. doi Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder
    Martin Poot
    Department of Medical Genetics, University Medical Centre Utrecht, Mail stop KC 04 084 2, P O Box 85090, 3508, Utrecht, The Netherlands
    Neurogenetics 11:81-9. 2010
    ..an additional de novo deletion encompassing the distal part of intron1 and exon 2 of CNTNAP2, which contains FOXP2 binding sites...
  53. pmc Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2
    T Kume
    Howard Hughes Medical Institute, Nashville, Tennessee 37232 2175, USA
    Mol Cell Biol 20:1419-25. 2000
    ..These data suggest that Mf2 can play a unique role in kidney development, but there is functional redundancy in this organ and other tissues with other forkhead/winged helix genes...
  54. ncbi The songbird as a model for the generation and learning of complex sequential behaviors
    Michale S Fee
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    ILAR J 51:362-77. 2010
    ..multiple times during evolution to play a role in learned vocal communication, such as the transcription factor FoxP2 and its molecular targets...
  55. pmc Translocation breakpoint at 7q31 associated with tics: further evidence for IMMP2L as a candidate gene for Tourette syndrome
    Chirag Patel
    Department of Clinical Genetics, Birmingham Women s Hospital NHS Foundation Trust, Birmingham, UK
    Eur J Hum Genet 19:634-9. 2011
    ..The deleted region (7q31.1-7q31.2) of 7.2 Mb of genomic DNA also encompasses numerous genes, including FOXP2, associated with verbal dyspraxia, and the CFTR gene.
  56. ncbi Qa-1b and CD94-NKG2a interaction regulate cytolytic activity of herpes simplex virus-specific memory CD8+ T cells in the latently infected trigeminal ganglia
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 176:1703-11. 2006
    ..Our results demonstrate the operation of a regulatory system in vivo that serves to protect irreplaceable neurons from destruction by the immune system...
  57. ncbi Molecular genetic determinants of human brain size
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 345:911-6. 2006
    ..Understanding the mechanism for developmental control of brain organogenesis by these genes, and others such as FOXP2, shall provide fresh perspectives on the evolution of human intelligence.
  58. pmc Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly
    A J Mears
    Departments of Ophthalmology and Medical Genetics, University of Alberta, Edmonton, Alberta, Canada
    Am J Hum Genet 63:1316-28. 1998
    ....
  59. pmc Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae
    Kenneth L Scott
    Department of Molecular and Human Genetics, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 23:4522-31. 2003
    ..cerevisiae. Inhibition of histone deacetylation results in a DNA damage checkpoint response mediated by the spindle checkpoint pathway that compensates for loss of the primary DNA damage checkpoint pathway...
  60. pmc Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
    Weiguo Shu
    Molecular Cardiology Research Center, Department of Medicine, University of Pennsylvania Medical Center, 956 Biomedical Research Building II III, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:9643-8. 2005
    ..The gene responsible for the phenotype was mapped to chromosome 7q31 and identified as the FOXP2 gene, coding for a transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain...
  61. ncbi Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis
    Jerry Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Immunol 176:3950-7. 2006
    ....
  62. pmc Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells
    Haiying Liu
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow G11 6NT, United Kingdom
    Proc Natl Acad Sci U S A 103:7048-53. 2006
    ..In the process, BLP also expands the Tregs, which recover their suppressive activity when the infection has subsided, in time to limit potential autoimmunity that might result from the overactivated effectors...
  63. ncbi Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and review
    P A Lennon
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 143:791-8. 2007
    ..family, in which half the members had severe specific language impairment, aided the localization of the SPCH1 locus to 7q31 within markers D7S2459 (107.1 Mb) and D7S643 (120.5 Mb)...
  64. pmc FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    Tao Zuo
    Program in Molecular, Cellular, and Developmental Biology and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Cell 129:1275-86. 2007
    ..Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene...
  65. ncbi Intratumoral FOXP3 expression in infiltrating breast carcinoma: Its association with clinicopathologic parameters and angiogenesis
    Sachin Gupta
    Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Acta Oncol 46:792-7. 2007
    ..A linear association of intratumoral FOXP3 expression with invasion, size and vascularity suggests a utility of FOXP3, an indicator of Treg activity as a marker of tumor progression and metastasis in breast carcinoma...
  66. pmc Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40
    Wanda Niedbala
    Division of Immunology, Infection, and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 104:15478-83. 2007
    ..Therefore, our findings uncovered a previously unrecognized function of NO via the NO-p53-IL-2-OX40-survivin signaling pathway for T cell differentiation and development...
  67. pmc Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area X
    Sebastian Haesler
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Biol 5:e321. 2007
    The gene encoding the forkhead box transcription factor, FOXP2, is essential for developing the full articulatory power of human language...
  68. pmc Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 99:56-70. 2008
    ..with schizophrenia or autism including Sema3a, Trfr2 and Vldlr were found to be altered as were protein levels of Foxp2. E18 infection of C57BL6J mice with a sublethal dose of human influenza virus led to significant gene alterations ..
  69. pmc Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant
    Philaiporn Vivatbutsiri
    Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Japan
    J Anat 212:603-11. 2008
    ..These results suggest that there is a close association between meningeal development and the apical growth of the skull bones...
  70. doi Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectives
    Hermann Ackermann
    Center for Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Strasse 3, D 72076 Tuebingen, Germany
    Trends Neurosci 31:265-72. 2008
    ..Recent genetic studies indicate that distinct mutations of a specific regulatory gene (FOXP2) promoted the emergence of articulate speech during the course of hominid evolution...
  71. ncbi Transcription factor FOXC2 demarcates the jugular lymphangiogenic region in avian embryos
    K Rutscher
    Centre of Anatomy, Department of Anatomy and Cell Biology, University Medicine Gottingen, Gottingen, Germany
    Lymphology 41:11-7. 2008
    ..Our data suggest that FoxC2, in addition to its late functions during lymph collector differentiation, has an early function during lymphendothelial commitment of venous ECs in the jugular region...
  72. pmc Foxp3 processing by proprotein convertases and control of regulatory T cell function
    Edwin F de Zoeten
    Division of Gastroenterology Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Biol Chem 284:5709-16. 2009
    ..The mechanism by which Foxp3 is processed likely extends to other members of the FoxP subfamily, because Foxp1 and Foxp2 also have N-terminal RXXR proteolytic cleavage motifs at similar locations to Foxp3...
  73. doi FOXP2 as a molecular window into speech and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 25:166-77. 2009
    Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits...
  74. doi Characterization of grass carp (Ctenopharyngodon idellus) Foxp1a/1b/2: evidence for their involvement in the activation of peripheral blood lymphocyte subpopulations
    Mu Yang
    School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People s Republic of China
    Fish Shellfish Immunol 28:289-95. 2010
    ..In this study, we obtained the complete cDNAs of grass carp Foxp1a, Foxp1b and Foxp2. They possess the conserved leucine zipper domain, zinc finger domain and forkhead domain when compared with their ..
  75. pmc Late-postnatal cannabinoid exposure persistently increases FoxP2 expression within zebra finch striatum
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Dev Neurobiol 70:195-203. 2010
    ..We are currently working to identify physiological substrates for this altered song learning. FoxP2 is a transcription factor associated with altered vocal development in both zebra finches and humans...
  76. pmc Recent advances in the genetics of language impairment
    Dianne F Newbury
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Genome Med 2:6. 2010
    ..So far, variants in four specific genes have been associated with spoken language disorders - forkhead box P2 (FOXP2) and contactin-associated protein-like 2 (CNTNAP2) on chromosome7 and calcium-transporting ATPase 2C2 (ATP2C2) and ..
  77. doi Regulatory T cells/T-helper cell 17 functional imbalance in uraemic patients on maintenance haemodialysis: a pivotal link between microinflammation and adverse cardiovascular events
    Jianbin Zhang
    Department of Nephrology, First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China
    Nephrology (Carlton) 15:33-41. 2010
    ..The aim of the present study was to assess the Treg/Th17 pattern in uraemic patients on MHD and to explore the significance of Treg/Th17 imbalance in the development and outcome of acute cardiovascular events...
  78. pmc Chiari I malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiency
    Christopher W Carr
    Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Eur J Hum Genet 18:1216-20. 2010
    Human FOXP2 deficiency has been identified as a cause of hereditary developmental verbal dyspraxia...
  79. pmc FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies
    Amparo Tolosa
    Department of Genetics, Faculty in Biology, University of Valencia, C Doctor Moliner 50, Burjassot, Valencia, Spain
    BMC Med Genet 11:114. 2010
    ..b>FOXP2 shows two important features as a convincing candidate gene for schizophrenia vulnerability: FOXP2 is the first ..
  80. doi Humanized Foxp2 specifically affects cortico-basal ganglia circuits
    S Reimers-Kipping
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Neuroscience 175:75-84. 2011
    It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution and influence aspects of speech and language...
  81. pmc Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding
    Yuan Ping Chu
    Department of Biochemistry and Molecular Biology, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Protein Sci 20:908-24. 2011
    ..The solution structure of FOXP1 A39P/C61Y mutant was similar to the X-ray structure of the FOXP2 monomer...
  82. pmc Genes expressed in specific areas of the human fetal cerebral cortex display distinct patterns of evolution
    Nelle Lambert
    Institut de Recherches en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 6:e17753. 2011
    ..Genes differentially expressed between cortical regions were also enriched for transcriptional targets of FoxP2, a key gene for the acquisition of language abilities in humans...
  83. pmc Foxp2 mutations impair auditory-motor association learning
    Simone Kurt
    Institute of Neurobiology, University of Ulm, Ulm, Germany
    PLoS ONE 7:e33130. 2012
    Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-described examples of monogenic speech and language disorders...
  84. doi Analysis of two language-related genes in autism: a case-control association study of FOXP2 and CNTNAP2
    Claudio Toma
    Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Spain
    Psychiatr Genet 23:82-5. 2013
    ..Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder...
  85. doi Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid
    E Antiga
    Department of Critical Care, Section of Dermatology, University of Florence, Florence, Italy
    J Eur Acad Dermatol Venereol 28:222-30. 2014
    ..Although regulatory T cells (Tregs) are affected in several autoimmune skin diseases, only two studies have been performed in patients with bullous pemphigoid (BP) with contrasting results...
  86. pmc Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neurons
    Glenn S Belinsky
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
    Stem Cell Res 12:101-18. 2014
    ..and single-cell PCR for 13 genes: ACTB, HPRT, vGLUT1, βTUBIII, COMT, DISC1, GAD1, PAX6, DTNBP1, ERBB4, FOXP1, FOXP2, and GIRK2...
  87. pmc Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication event
    Xiaowei Song
    Department of Herpetology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China College of Life Science, Sichuan University, Chengdu, Sichuan, China University of Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e83858. 2013
    As one of the most conserved genes in vertebrates, FoxP2 is widely involved in a number of important physiological and developmental processes...
  88. doi Etiological yield of SNP microarrays in idiopathic intellectual disability
    G Eda Utine
    Hacettepe University, Department of Pediatrics, Ankara, Turkey Hacettepe University, Department of Pediatric Genetics, Ankara, Turkey Electronic address
    Eur J Paediatr Neurol 18:327-37. 2014
    ..Two separate patients had deletions in FOXP2 and UBE2A genes, respectively, for which only few patients have recently been reported...
  89. ncbi The plateau zokors' learning and memory ability is related to the high expression levels of foxP2 in the brain
    Ben Yuan Ma
    Department of Biology, Qinghai University, Xining 810016, China
    Sheng Li Xue Bao 66:135-44. 2014
    ..Forkhead box p2 (FOXP2) is a transcription factor implicated in the neural control of orofacial coordination and sensory-motor ..
  90. doi Brain mechanisms of acoustic communication in humans and nonhuman primates: an evolutionary perspective
    Hermann Ackermann
    Neurophonetics Group, Centre for Neurology General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D 72076
    Behav Brain Sci 37:529-46. 2014
    ..ii) subsequent vocal-laryngeal elaboration of cortico-basal ganglia circuitries, driven by human-specific FOXP2 mutations...
  91. doi Genetic and Developmental Perspective of Language Abnormality in Autism and Schizophrenia: One Disease Occurring at Different Ages in Humans?
    Haoran George Wang
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neuroscientist 22:119-31. 2016
    ..We found many functional genes, for example, FOXP2, COMT, GABRB3, and DISC1, are actually implicated in both of them...
  92. doi Downregulation of FOXP2 promoter human hepatocellular carcinoma cell invasion
    Xia Yan
    Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China
    Tumour Biol 36:9611-9. 2015
    ..However, the mechanism underlying hepatocarcinogenesis remains unclear. Forkhead box P2 (FOXP2) has been implicated in various human cancer types. However, the role of FOXP2 in HCC remains unknown...
  93. pmc Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes
    Matthew L Kraushar
    Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School and
    J Neurosci 35:10911-26. 2015
    ..Thalamic WNT3 regulates neocortical translation of two such mRNAs, Foxp2 and Apc, to promote FOXP2 expression while inhibiting APC expression, thereby driving neocortical neuronal ..
  94. doi Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation
    Mohammad Khaja Mafij Uddin
    Department of Biochemistry, Hamamatsu University School of Medicine
    Biomed Res 36:235-45. 2015
    ..Our data therefore provide for a detailed understanding of the role of mesenchymal Foxc2 in aortic arch remodelling and in the development of ventricular septum. ..
  95. pmc Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: A comparative analysis of the primate basal ganglia
    Mary Ann Raghanti
    Department of Anthropology, Kent State University, Kent, Ohio, 44242
    J Comp Neurol 524:2117-29. 2016
    ..uniquely human cognitive and behavioral abilities, including the association of the human-specific sequence of the FOXP2 gene with decreased dopamine in the dorsomedial striatum of mice...
  96. pmc Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development
    Jeffry M Cesario
    Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010 United States
    Gene Expr Patterns 20:111-9. 2016
    ..of oral development, repressed the expression of the genes encoding forkhead box transcription factors, Foxp1 and Foxp2, in the oral region...
  97. pmc Partial Conservation between Mice and Humans in Olfactory Bulb Interneuron Transcription Factor Codes
    Nana Fujiwara
    Burke Medical Research Institute White Plains, NY, USA
    Front Neurosci 10:337. 2016
    ..This study compared the co-expression of Foxp2, Meis2, Pax6, and Sp8 transcription factors with Calretinin, Calbindin, or Th in human and mouse OB interneurons...
  98. pmc Role of miRNA-9 in Brain Development
    Balachandar Radhakrishnan
    School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
    J Exp Neurosci 10:101-120. 2016
    ..Targeting Foxp1 and Foxp2, and Map1b by miR-9 regulates the radial migration of neurons and axonal development...
  99. pmc Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy
    Yuan yuan Ding
    Department of Pharmacology, College of Pharmacy, Third Military Medical University Chongqing, China
    Front Pharmacol 7:471. 2016
    ..In conclusion, TP can effectively ameliorate myocardial damage and inhibit cardiac hypertrophy, which is at least partly related to the elevation of Foxp3 expression in cardiomyocytes...
  100. ncbi Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member
    S L Brody
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Genomics 45:509-18. 1997
    ....

Research Grants32

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. Stephanie Ann White; Fiscal Year: 2016
    ..We use songbirds to investigate FoxP2- a conserved transcription factor whose mutation causes a severe language disorder as an entry point into the ..
  3. FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions
    Genevieve Konopka; Fiscal Year: 2010
    ..The transcription factor FOXP2 is the only gene currently identified that is mutated in patients with isolated language disturbances, and it has ..
  4. Bennett G Novitch; Fiscal Year: 2014
    ..transcription factor family are progressively expressed as motor neuron differentiation proceeds, beginning with Foxp2 in dividing progenitors, followed by Foxp4 as the cells differentiate, and then Foxp1 in subsets of postmitotic ..
  5. Investigating the role of CNTNAP2 gene in vocal learning in mutant songbirds
    Carlos Lois; Fiscal Year: 2013
    ..In recent years a number of genes, including the transcription factor FoxP2 and its target CNTNAP2, have been linked to language specific impairments and to ASD in humans, suggesting that ..
  6. Transfusion-associated immune hemolysis
    Karina Yazdanbakhsh; Fiscal Year: 2010
    ..In our grant application, we will expand our animal studies to focus on the triggers that make immune cells accept or reject transfused blood. ..
  7. JERALD MICHAEL BOWERS; Fiscal Year: 2014
    ..Moreover, the gene FOXP2 is known to be expressed in several areas of the brain involved in vocal communication in animals and language in ..
  8. Transcriptional Regulation of Myogenic Stem Cells
    Daniel J Garry; Fiscal Year: 2013
    ..This proposal will decipher the molecular pathways that govern muscle stem cells and may ultimately lead to novel therapies directed towards an enhanced regenerative response in patients with myopathic diseases. ..
  9. Sudha K Iyengar; Fiscal Year: 2016
    ..A decade ago, identification of a highly penetrant, discrete genetic variant in FOXP2 in a single family was the first step for the field of speech and language disorders...
  10. FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions
    Genevieve Konopka; Fiscal Year: 2013
    ..mouse brain, and 3) Ascertain how Fdxp2 and Foxpl cooperatively regulate gene expression during CNS development by generating Foxpl conditional knockout mice and conducting genome wide Foxp2 promoter binding analysis.
  11. FoxP3 as the X-Linked Breast Cancer Suppressor Gene
    Yang Liu; Fiscal Year: 2010
    ....
  12. Neurogenomics in a Model for Procedural Learning
    AUSTIN HILLIARD; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): FoxP2 is currently the only molecule directly linked to a developmental onset human speech and language disorder...
  13. Characterization and Genetic Analysis of Basal Ganglia Axon Pathfinding
    JOSH LEITCH BONKOWSKY; Fiscal Year: 2013
    ..pathfinding, I have generated novel enhancer lines specific for basal ganglia neurons, including dlx(mini):gfp and foxP2-enhancerA:egfp. Aim 2...
  14. DEVELOPMENT OF SYNAPTIC INPUTS ON SPINAL INTERNEURONS
    Francisco J Alvarez; Fiscal Year: 2013
    ..Thus, we divided V1s in an early generated group (that includes Renshaw cells and lack expression of FoxP2) and a late generated group (that includes IaINs and are FoxP2+)...
  15. The role of stress and FoxP2 in adult vocal learning: tests using a parrot model
    Timothy F Wright; Fiscal Year: 2013
    ..the primary stress hormone in birds) on learning in juveniles and adults, and iii) the role of the gene FoxP2 in learning in juveniles and adults...
  16. The Role of FoxP2 in Olfactory Bulb Interneuron Neurogenesis
    Zegary J Allen; Fiscal Year: 2010
    ..In this study I aim to determine the role of the recently identified winged helix/forkhead transcription factor Foxp2 in the generation of olfactory bulb interneurons...
  17. Foxp2 and vocal communication: a new mammalian model
    Polly Campbell; Fiscal Year: 2009
    ..We focus on the expression and function of Foxp2, a gene implicated in both the evolution of human language and the genesis of human communicative disorders...
  18. Identification of targets of FoxP2 in the brain
    Daniel Geschwind; Fiscal Year: 2006
    ..Recently a mutation in the FOXP2 gene was identified in a family with a speech and language development disorder including orofacial dyspraxia and ..
  19. Structure and Function of the FOXP Family of Transcription Factors
    Lin Chen; Fiscal Year: 2009
    ..Mutations in FOXP proteins have been linked to human autoimmune disease (FOXP3) and speech disorder (FOXP2). Other members of the FOXP family have been implicated in tumor suppression (FOXP1) and lung development (FOXP4)...
  20. Role of the Foxn4 Gene during Retinogenesis
    Mengqing Xiang; Fiscal Year: 2007
    ..abstract_text> ..
  21. Role of FoxP2 in AEC (trans)differentiation
    Zea Borok; Fiscal Year: 2008
    ..b>FoxP2 is the only member of the Fox family of transcription factors (TF) that is exclusively expressed in distal lung ..
  22. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  23. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  24. The Genetics of Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2009
    ..speech and language impairment, who also have a chromosomal translocation that appears to involve the FOXP2 gene. The FOXP2 gene is known to be a regulatory gene implicated in developmental speech and language disorder...
  25. Identifying human adaptations: theory and applications
    Molly Przeworski; Fiscal Year: 2009
    ..Thus, the proposed research will generate new statistical tools for the detection of regions of functional importance and will identify the first set of candidates for human-specific adaptations in gene expression regulation. ..
  26. De novo induction of Foxp3+ regulatory T cells in tumor microenvironment
    F XIAOFENG QIN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. MOLECULAR GENETICS OF AUTISM
    Thomas Wassink; Fiscal Year: 2006
    ..The WNT2 findings will be further examined in two-independent patient samples. ..
  28. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
    ..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  29. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010
    ..These studies will also help understand human smell and taste variations and disorders. ..
  30. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010
    ....
  31. Collaboration on Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2005
    ..abstract_text> ..