Genomes and Genes
Gene Symbol: FOXP2
Description: forkhead box P2
Alias: CAGH44, SPCH1, TNRC10, forkhead box protein P2, CAG repeat protein 44, forkhead/winged-helix transcription factor, trinucleotide repeat containing 10, trinucleotide repeat-containing gene 10 protein
Publications222 found, 100 shown here
- cDNAs with long CAG trinucleotide repeats from human brainR L Margolis
Laboratory of Molecular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hum Genet 100:114-22. 1997..These genes are therefore candidates for diseases featuring anticipation, neurodegeneration, or abnormalities of neurodevelopment...
- A forkhead-domain gene is mutated in a severe speech and language disorderC S Lai
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nature 413:519-23. 2001..Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, ..
- FOXP2: novel exons, splice variants, and CAG repeat length stabilityHeather A Bruce
Laboratory of Genetic Neurobiology, Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hum Genet 111:136-44. 2002..2) with a breakpoint between exons 3b and 4 have recently been associated with a speech and language disorder (SPCH1)...
- Molecular evolution of FOXP2, a gene involved in speech and languageWolfgang Enard
Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
Nature 418:869-72. 2002..b>FOXP2 is the first gene relevant to the human ability to develop language...
- Accelerated protein evolution and origins of human-specific features: Foxp2 as an exampleJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 162:1825-35. 2002..Using comparative analysis of human, chimpanzee, and mouse protein sequences, we identified two genes (PRM2 and FOXP2) with significantly enhanced evolutionary rates in the hominid lineage...
- Identification of FOXP2 truncation as a novel cause of developmental speech and language deficitsKay D Macdermot
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Am J Hum Genet 76:1074-80. 2005b>FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a unique entry point into neuromolecular mechanisms influencing human speech and language acquisition...
- Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinationsJulio Sanjuan
Psychiatric Unit, Faculty of Medicine, Clinical Hospital, Valencia, Spain
Psychiatr Genet 16:67-72. 2006A mutation in the FOXP2 gene has been the first genetic association with a language disorder. Language disorder is considered as a core symptom of schizophrenia...
- Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxiaLars Feuk
The Centre for Applied Genomics and Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
Am J Hum Genet 79:965-72. 2006Mutations in FOXP2 cause developmental verbal dyspraxia (DVD), but only a few cases have been described...
- High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disordersSonja C Vernes
Wellcome Trust Centre for Human Genetics, The University of Oxford, Oxford, OX3 7BN, UK
Am J Hum Genet 81:1232-50. 2007We previously discovered that mutations of the human FOXP2 gene cause a monogenic communication disorder, primarily characterized by difficulties in learning to make coordinated sequences of articulatory gestures that underlie speech...
- Multiple transcription start sites for FOXP2 with varying cellular specificitiesDiane I Schroeder
Biomedical Informatics Program, Stanford University School of Medicine, Stanford, California 94305 5120, USA
Gene 413:42-8. 2008b>FOXP2 is a forkhead transcription factor implicated in developmental verbal dyspraxia, a human speech and language disorder. FOXP2 is expressed in complex patterns during brain, lung, heart, and gut development and on into adulthood...
- Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disordersFabrice Laroche
INSERM Avenir, Institut Jacques Monod UMR7592, Paris, France
Psychiatr Genet 18:295-301. 2008..Genetic studies have reported an association between autism and DLX2, HOXA1, EN2, ARX, and FOXP2 genes whereas only three studies of EN2, OTX2, and FOXP2 were performed on schizophrenia...
- A humanized version of Foxp2 affects cortico-basal ganglia circuits in miceWolfgang Enard
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Cell 137:961-71. 2009It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language...
- A functional genetic link between distinct developmental language disordersSonja C Vernes
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
N Engl J Med 359:2337-45. 2008Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment.
- FOXP2 polymorphisms in patients with schizophreniaJulio Sanjuan
Unidad de Psiquiatria, Facultad de Medicina, Hospital Clinico, Universitat de Valencia, Blasco Ibaez 15, 46010 Valencia, Spain
Schizophr Res 73:253-6. 2005b>FOXP2 was described as the first gene involved in our ability to acquire spoken language...
- Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brainElizabeth Spiteri
Program in Neurogenetics, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
Am J Hum Genet 81:1144-57. 2007Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the only known cause of developmental speech and language disorders in humans...
- [Effect of apoptosis of CD4+ CD25+ regulatory T lymphocytes on polarization of helper T lymphocytes and potential interventional influence of Xuebijing injection in septic rats]Xin gui Dai
Intensive Care Unit, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:135-8. 2009..To evaluate the influence of apoptosis of CD4(+)CD25(+) regulatory T lymphocyte (Treg) on polarization of helper T lymphocyte (Th) and effect of Xuebijing injection in septic rats...
- [Evolution of human brain and intelligence]Laszlo Lakatos
Pszichiátriai magánrendelés, Szekesfehervar
Ideggyogy Sz 61:220-9. 2008..The appearance and stabilisation of FOXP2 gene structure as feature of modern man coincided with the first presence and quick spread of Homo sapiens on the ..
- Reconstructing phylogenies and phenotypes: a molecular view of human evolutionBrenda J Bradley
Department of Zoology and Christ s College, University of Cambridge, UK
J Anat 212:337-53. 2008..Loci involved in speech (e.g. FOXP2), brain development (e.g. ASPM), and skull musculature (e.g...
- Alternative splicing and gene duplication in the evolution of the FoxP gene subfamilyM Emilia Santos
Departamento de Biologia Animal, Faculdade de Ciencias da Universidade de Lisboa, Lisboa, Portugal
Mol Biol Evol 28:237-47. 2011..Its four members, FoxP1-P4, have been extensively characterized functionally. FoxP1, FoxP2, and FoxP4 are involved in lung, heart, gut, and central nervous system (CNS) development...
- [Effects of Cordyceps extract on cytokines and transcription factors in peripheral blood mononuclear cells of asthmatic children during remission stage]Wen Sun
Department of Traditional Chinese Medicine, Children s Hospital, Fudan University, Shanghai 201102, China
Zhong Xi Yi Jie He Xue Bao 8:341-6. 2010..To explore the effects of Cordyceps extract in regulating the imbalance of Th1/Th2 ratio and inhibiting the inflammatory reaction, and to find the theoretical basis of Cordyceps extract for treating asthma in remission stage...
- Area postrema projects to FoxP2 neurons of the pre-locus coeruleus and parabrachial nuclei: brainstem sites implicated in sodium appetite regulationMatthew K Stein
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Brain Res 1359:116-27. 2010..Both pontine cell groups express the transcription factor FoxP2 and become c-Fos activated following sodium depletion...
- FoxP2 expression in avian vocal learners and non-learnersSebastian Haesler
Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
J Neurosci 24:3164-75. 2004..b>FOXP2 is the first gene linked to human speech and has been the target of positive selection during recent primate ..
- Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cellsThirajit Boonsaen
Department of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
Biochem J 405:359-67. 2007..2 kb promoter fragment. The results presented here show that Foxa2 and USFs regulate the distal promoter of the rat PC gene in a cell-specific manner...
- Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitisMaria Serena Longhi
Institute of Liver Studies, King s College London School of Medicine at King s College Hospital, Denmark Hill, London, UK
Hepatology 47:581-91. 2008..Suppressor function and FOXP3 expression of both expanded and newly generated T-regs were higher in normal controls than in AIH patients...
- Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2Kaoru Takahashi
Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Tokyo 194 8511, Japan
J Comp Neurol 509:180-9. 2008..By using the developing monkey brain as a model for human development, we investigated the expression pattern of the FOXP2 gene, a member of the FOX family of transcription factors in the developing monkey brain, and compared its ..
- Characterization of regulatory T cells in patients with dermatomyositisE Antiga
Department of Dermatological Sciences, University of Florence, Florence, Italy
J Autoimmun 35:342-50. 2010..05). These data suggest that the depletion of T(reg) and their main effector cytokines in the skin and the serum of patients with DM may be an important factor in the pathogenesis of the disease...
- Genetic components of vocal learningConstance Scharff
Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
Ann N Y Acad Sci 1016:325-47. 2004..Special attention is given to a particular gene, FOXP2, which has been implicated in a human speech and language disorder...
- Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1cYifang Chen
Department of Pathology, Immunology, and Laboratory Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
J Immunol 175:1080-9. 2005....
- Induction of FoxP3+CD4+25+ regulatory T cells following hemopoietic stem cell transplantation: role of bone marrow-derived facilitating cellsKendra N Taylor
Division of Thoracic Surgery, Department of Surgery Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 179:2153-62. 2007..The transplantation of donor FC may provide an alternative approach to permit clinical SC engraftment and induction of transplantation tolerance in the future...
- Absence of amplification of CD4+CD25(high) regulatory T cells during in vitro expansion of tumor-infiltrating lymphocytes in melanoma patientsAnne Chantal Knol
INSERM, U601, 9 Quai Moncousu Nantes Cedex 01, France
Exp Dermatol 17:436-45. 2008..These cells were indeed Treg cells as they expressed Foxp3. In conclusion, our work suggests that CD4+CD25(high) Foxp3 expressing T cells are not expanded during in vitro amplification of TIL obtained from melanoma-invaded LNs...
- Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cellsEriko Fujita
Divisions of Development and Differentiation, Department of Human Inherited Metabolic Disease, National Institute of Neuroscience, 4 1 1 Ogawahigashi machi, Kodaira, Tokyo 187 8502, Japan
Proc Natl Acad Sci U S A 105:3117-22. 2008Previous studies have demonstrated that mutation in the forkhead domain of the forkhead box P2 (FOXP2) protein (R553H) causes speech-language disorders...
- The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortexT Hisaoka
Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
Neuroscience 166:551-63. 2010Foxp1 and Foxp2, which belong to the forkhead transcription factor family, are expressed in the developing and adult mouse brain, including the striatum, thalamus, and cerebral cortex...
- Knockdown of FoxP2 alters spine density in Area X of the zebra finchS B Schulz
Freie Universitat Berlin, Laboratory of Animal Behavior, Berlin, Germany
Genes Brain Behav 9:732-40. 2010Mutations in the gene encoding the transcription factor FoxP2 impair human speech and language...
- FoxP2 regulation during undirected singing in adult songbirdsIkuko Teramitsu
Interdepartmental Programs in Molecular, Cellular, and Integrative Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 26:7390-4. 2006..To date, FOXP2 (forkhead box P2), a transcriptional repressor, is the only molecule directly linked to human speech...
- Assessing the impact of FOXP1 mutations on developmental verbal dyspraxiaSonja C Vernes
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
Eur J Hum Genet 17:1354-8. 2009..One exception is the identification of rare heterozygous mutations of the FOXP2 gene in a monogenic syndrome characterised by impaired sequencing of articulatory gestures, disrupting speech (..
- Song practice promotes acute vocal variability at a key stage of sensorimotor learningJulie E Miller
Department of Physiological Science, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e8592. 2010..In juvenile and adult male zebra finches, endogenous levels of FoxP2, a molecule critical for language, decrease two hours after morning song onset within area X, part of the basal ..
- The potential effect and mechanism of high-mobility group box 1 protein on regulatory T cell-mediated immunosuppressionYing Zhang
Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to Chinese PLA General Hospital, Beijing, People s Republic of China
J Interferon Cytokine Res 31:249-57. 2011..HMGB1 appears to be involved in modulating cell-mediated immunity by influencing proliferation of effector T cells, secretion of IL-2, and cell polarization...
- Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotypeT Schlake
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg, Germany
Dev Dyn 217:368-76. 2000..Our results implicate Whn as a transcriptional regulator of hair keratin genes and reveal the nude phenotype as the first example of an inherited skin disorder that is caused by loss of expression rather than mutation of keratin genes...
- Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cellsMark Christian
Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
J Biol Chem 277:20825-32. 2002..These results provide the first evidence of regulated expression of FKHR and demonstrate that FKHR has an integral role in PKA-dependent endometrial differentiation through its ability to bind and functionally cooperate with C/EBPbeta...
- Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMPMaria K Dahle
Department of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
J Biol Chem 277:22902-8. 2002..In summary, winged helix transcription factors of the FOXC/FOXD families function as regulators of the RI alpha subunit of PKA and may integrate hormonal signals acting through protein kinase B and cAMP in a cell-specific manner...
- [The aetiopathogenesis of auditory hallucinations in psychosis]J Sanjuan
Unidad de Psiquiatria, Facultad de Medicina Universidad de Valencia, 46010 Valencia, Espana
Rev Neurol 43:280-6. 2006..Neither of these approaches are listening to each other. Neither of them look at the molecular genetic vulnerability to auditory hallucinations in psychosis...
- Expression of Foxp4 in the developing and adult rat forebrainKaoru Takahashi
Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan
J Neurosci Res 86:3106-16. 2008..the expression pattern of Foxp4, a member of the Foxp subfamily, and compared its pattern with the patterns of Foxp2 and Foxp1 in the developing rat brain...
- [Significance of CD4+ CD25+ CD127(low) regulatory T cells and notch1 pathway in the pathogenesis of aplastic anemia]Xiao Xiao Yin
Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, China
Zhonghua Xue Ye Xue Za Zhi 29:308-11. 2008....
- Conservation and diversity of Foxp2 expression in muroid rodents: functional implicationsPolly Campbell
Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
J Comp Neurol 512:84-100. 2009b>FOXP2, the first gene causally linked to a human language disorder, is implicated in song acquisition, production, and perception in oscine songbirds, the evolution of speech and language in hominids, and the evolution of echolocation in ..
- The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformationPedro Farinha
Pathology and Laboratory Medicine, BC Cancer Agency Center for Lymphoid Cancers, Vancouver, BC, Canada
Blood 115:289-95. 2010..008 and P < .001, respectively), while only FOXP3(+) pattern predicted RT (P = .004). We conclude that FOXP3(+) cell distribution significantly predicts survival and RT in FL...
- The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle developmentDeidre Mattiske
Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC 27710, USA
Dev Biol 290:447-58. 2006..We conclude that alongside its previously known roles in kidney, cardiovascular and eye development, Foxc1 has essential functions during at least two stages of gonad development-germ cell migration and folliculogenesis...
- De-novo balanced translocation between 7q31 and 10p14 in a girl with central precocious puberty, moderate mental retardation, and severe speech impairmentTomoki Kosho
Department of Medical Genetics, Shinshu University School of Medicine, Matsumoto, Japan
Clin Dysmorphol 17:31-4. 2008No causative gene has been found for idiopathic central precocious puberty; and FOXP2, located in 7q31, is the only known gene for speech and language disturbances...
- Cre fate mapping reveals lineage specific defects in neuronal migration with loss of Pitx2 function in the developing mouse hypothalamus and subthalamic nucleusJennifer M Skidmore
Department of Pediatrics, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Mol Cell Neurosci 37:696-707. 2008..arrested in Pitx2(cre/null) embryos, and subclasses of subthalamic nucleus neurons identified by Lmx1b, Foxp1, and Foxp2-gene expression revealed differing sensitivities to Pitx2 dosage...
- Mycobacterium bovis bacillus Calmette-Guérin killed by extended freeze-drying targets plasmacytoid dendritic cells to regulate lung inflammationMicheline Lagranderie
Laboratoire d Immunothérapie, Institut Pasteur, Paris, France
J Immunol 184:1062-70. 2010..EFD BCG reduced allergic inflammation by recruiting pDCs that promoted Tregs; EFD BCG acted as a peroxisome proliferator-activated receptor gamma agonist and thus could be used in asthma and other inflammatory diseases...
- Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cellsEstelle Bettelli
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:5138-43. 2005..Here, we show that, among the Foxp transcriptional factor family, which includes Foxp1, Foxp2, and Foxp3, only Foxp3 has the ability to inhibit IL-2, IL-4, and IFN-gamma production by primary T helper cells...
- A model of early molecular regionalization in the chicken embryonic pretectumJ L Ferran
Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain
J Comp Neurol 505:379-403. 2007..We examined in detail Pax3, Pax6, Pax7, Tcf4, Meis1, Meis2, Nkx2.2, Lim1, Dmbx1, Dbx1, Six3, FoxP2, Zic1, Ebf1, and Shh mRNA expression, as well as PAX3 and PAX7 immunoreaction, between stages HH11 and HH28...
- Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorderMartin Poot
Department of Medical Genetics, University Medical Centre Utrecht, Mail stop KC 04 084 2, P O Box 85090, 3508, Utrecht, The Netherlands
Neurogenetics 11:81-9. 2010..an additional de novo deletion encompassing the distal part of intron1 and exon 2 of CNTNAP2, which contains FOXP2 binding sites...
- Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2T Kume
Howard Hughes Medical Institute, Nashville, Tennessee 37232 2175, USA
Mol Cell Biol 20:1419-25. 2000..These data suggest that Mf2 can play a unique role in kidney development, but there is functional redundancy in this organ and other tissues with other forkhead/winged helix genes...
- The songbird as a model for the generation and learning of complex sequential behaviorsMichale S Fee
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
ILAR J 51:362-77. 2010..multiple times during evolution to play a role in learned vocal communication, such as the transcription factor FoxP2 and its molecular targets...
- Translocation breakpoint at 7q31 associated with tics: further evidence for IMMP2L as a candidate gene for Tourette syndromeChirag Patel
Department of Clinical Genetics, Birmingham Women s Hospital NHS Foundation Trust, Birmingham, UK
Eur J Hum Genet 19:634-9. 2011..The deleted region (7q31.1-7q31.2) of 7.2 Mb of genomic DNA also encompasses numerous genes, including FOXP2, associated with verbal dyspraxia, and the CFTR gene.
- Qa-1b and CD94-NKG2a interaction regulate cytolytic activity of herpes simplex virus-specific memory CD8+ T cells in the latently infected trigeminal gangliaSusmit Suvas
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 176:1703-11. 2006..Our results demonstrate the operation of a regulatory system in vivo that serves to protect irreplaceable neurons from destruction by the immune system...
- Molecular genetic determinants of human brain sizeBor Luen Tang
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
Biochem Biophys Res Commun 345:911-6. 2006..Understanding the mechanism for developmental control of brain organogenesis by these genes, and others such as FOXP2, shall provide fresh perspectives on the evolution of human intelligence.
- Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomalyA J Mears
Departments of Ophthalmology and Medical Genetics, University of Alberta, Edmonton, Alberta, Canada
Am J Hum Genet 63:1316-28. 1998....
- Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiaeKenneth L Scott
Department of Molecular and Human Genetics, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 23:4522-31. 2003..cerevisiae. Inhibition of histone deacetylation results in a DNA damage checkpoint response mediated by the spindle checkpoint pathway that compensates for loss of the primary DNA damage checkpoint pathway...
- Altered ultrasonic vocalization in mice with a disruption in the Foxp2 geneWeiguo Shu
Molecular Cardiology Research Center, Department of Medicine, University of Pennsylvania Medical Center, 956 Biomedical Research Building II III, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:9643-8. 2005..The gene responsible for the phenotype was mapped to chromosome 7q31 and identified as the FOXP2 gene, coding for a transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain...
- Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitisJerry Y Niederkorn
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Immunol 176:3950-7. 2006....
- Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cellsHaiying Liu
Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow G11 6NT, United Kingdom
Proc Natl Acad Sci U S A 103:7048-53. 2006..In the process, BLP also expands the Tregs, which recover their suppressive activity when the infection has subsided, in time to limit potential autoimmunity that might result from the overactivated effectors...
- Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and reviewP A Lennon
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
Am J Med Genet A 143:791-8. 2007..family, in which half the members had severe specific language impairment, aided the localization of the SPCH1 locus to 7q31 within markers D7S2459 (107.1 Mb) and D7S643 (120.5 Mb)...
- FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogeneTao Zuo
Program in Molecular, Cellular, and Developmental Biology and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH 43210, USA
Cell 129:1275-86. 2007..Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene...
- Intratumoral FOXP3 expression in infiltrating breast carcinoma: Its association with clinicopathologic parameters and angiogenesisSachin Gupta
Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Acta Oncol 46:792-7. 2007..A linear association of intratumoral FOXP3 expression with invasion, size and vascularity suggests a utility of FOXP3, an indicator of Treg activity as a marker of tumor progression and metastasis in breast carcinoma...
- Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40Wanda Niedbala
Division of Immunology, Infection, and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
Proc Natl Acad Sci U S A 104:15478-83. 2007..Therefore, our findings uncovered a previously unrecognized function of NO via the NO-p53-IL-2-OX40-survivin signaling pathway for T cell differentiation and development...
- Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area XSebastian Haesler
Max Planck Institute for Molecular Genetics, Berlin, Germany
PLoS Biol 5:e321. 2007The gene encoding the forkhead box transcription factor, FOXP2, is essential for developing the full articulatory power of human language...
- Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disordersS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 99:56-70. 2008..with schizophrenia or autism including Sema3a, Trfr2 and Vldlr were found to be altered as were protein levels of Foxp2. E18 infection of C57BL6J mice with a sublethal dose of human influenza virus led to significant gene alterations ..
- Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutantPhilaiporn Vivatbutsiri
Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Japan
J Anat 212:603-11. 2008..These results suggest that there is a close association between meningeal development and the apical growth of the skull bones...
- Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectivesHermann Ackermann
Center for Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Strasse 3, D 72076 Tuebingen, Germany
Trends Neurosci 31:265-72. 2008..Recent genetic studies indicate that distinct mutations of a specific regulatory gene (FOXP2) promoted the emergence of articulate speech during the course of hominid evolution...
- Transcription factor FOXC2 demarcates the jugular lymphangiogenic region in avian embryosK Rutscher
Centre of Anatomy, Department of Anatomy and Cell Biology, University Medicine Gottingen, Gottingen, Germany
Lymphology 41:11-7. 2008..Our data suggest that FoxC2, in addition to its late functions during lymph collector differentiation, has an early function during lymphendothelial commitment of venous ECs in the jugular region...
- Foxp3 processing by proprotein convertases and control of regulatory T cell functionEdwin F de Zoeten
Division of Gastroenterology Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
J Biol Chem 284:5709-16. 2009..The mechanism by which Foxp3 is processed likely extends to other members of the FoxP subfamily, because Foxp1 and Foxp2 also have N-terminal RXXR proteolytic cleavage motifs at similar locations to Foxp3...
- FOXP2 as a molecular window into speech and languageSimon E Fisher
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
Trends Genet 25:166-77. 2009Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits...
- Characterization of grass carp (Ctenopharyngodon idellus) Foxp1a/1b/2: evidence for their involvement in the activation of peripheral blood lymphocyte subpopulationsMu Yang
School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People s Republic of China
Fish Shellfish Immunol 28:289-95. 2010..In this study, we obtained the complete cDNAs of grass carp Foxp1a, Foxp1b and Foxp2. They possess the conserved leucine zipper domain, zinc finger domain and forkhead domain when compared with their ..
- Late-postnatal cannabinoid exposure persistently increases FoxP2 expression within zebra finch striatumKen Soderstrom
Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
Dev Neurobiol 70:195-203. 2010..We are currently working to identify physiological substrates for this altered song learning. FoxP2 is a transcription factor associated with altered vocal development in both zebra finches and humans...
- Recent advances in the genetics of language impairmentDianne F Newbury
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
Genome Med 2:6. 2010..So far, variants in four specific genes have been associated with spoken language disorders - forkhead box P2 (FOXP2) and contactin-associated protein-like 2 (CNTNAP2) on chromosome7 and calcium-transporting ATPase 2C2 (ATP2C2) and ..
- Regulatory T cells/T-helper cell 17 functional imbalance in uraemic patients on maintenance haemodialysis: a pivotal link between microinflammation and adverse cardiovascular eventsJianbin Zhang
Department of Nephrology, First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China
Nephrology (Carlton) 15:33-41. 2010..The aim of the present study was to assess the Treg/Th17 pattern in uraemic patients on MHD and to explore the significance of Treg/Th17 imbalance in the development and outcome of acute cardiovascular events...
- Chiari I malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiencyChristopher W Carr
Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS 39216, USA
Eur J Hum Genet 18:1216-20. 2010Human FOXP2 deficiency has been identified as a cause of hereditary developmental verbal dyspraxia...
- FOXP2 gene and language impairment in schizophrenia: association and epigenetic studiesAmparo Tolosa
Department of Genetics, Faculty in Biology, University of Valencia, C Doctor Moliner 50, Burjassot, Valencia, Spain
BMC Med Genet 11:114. 2010..b>FOXP2 shows two important features as a convincing candidate gene for schizophrenia vulnerability: FOXP2 is the first ..
- Humanized Foxp2 specifically affects cortico-basal ganglia circuitsS Reimers-Kipping
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Neuroscience 175:75-84. 2011It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution and influence aspects of speech and language...
- Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA bindingYuan Ping Chu
Department of Biochemistry and Molecular Biology, National Cheng Kung University College of Medicine, Tainan, Taiwan
Protein Sci 20:908-24. 2011..The solution structure of FOXP1 A39P/C61Y mutant was similar to the X-ray structure of the FOXP2 monomer...
- Genes expressed in specific areas of the human fetal cerebral cortex display distinct patterns of evolutionNelle Lambert
Institut de Recherches en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
PLoS ONE 6:e17753. 2011..Genes differentially expressed between cortical regions were also enriched for transcriptional targets of FoxP2, a key gene for the acquisition of language abilities in humans...
- Foxp2 mutations impair auditory-motor association learningSimone Kurt
Institute of Neurobiology, University of Ulm, Ulm, Germany
PLoS ONE 7:e33130. 2012Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-described examples of monogenic speech and language disorders...
- Analysis of two language-related genes in autism: a case-control association study of FOXP2 and CNTNAP2Claudio Toma
Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Spain
Psychiatr Genet 23:82-5. 2013..Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder...
- Regulatory T cells in skin lesions and blood of patients with bullous pemphigoidE Antiga
Department of Critical Care, Section of Dermatology, University of Florence, Florence, Italy
J Eur Acad Dermatol Venereol 28:222-30. 2014..Although regulatory T cells (Tregs) are affected in several autoimmune skin diseases, only two studies have been performed in patients with bullous pemphigoid (BP) with contrasting results...
- Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neuronsGlenn S Belinsky
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
Stem Cell Res 12:101-18. 2014..and single-cell PCR for 13 genes: ACTB, HPRT, vGLUT1, βTUBIII, COMT, DISC1, GAD1, PAX6, DTNBP1, ERBB4, FOXP1, FOXP2, and GIRK2...
- Rapid diversification of FoxP2 in teleosts through gene duplication in the teleost-specific whole genome duplication eventXiaowei Song
Department of Herpetology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China College of Life Science, Sichuan University, Chengdu, Sichuan, China University of Chinese Academy of Sciences, Beijing, China
PLoS ONE 8:e83858. 2013As one of the most conserved genes in vertebrates, FoxP2 is widely involved in a number of important physiological and developmental processes...
- Etiological yield of SNP microarrays in idiopathic intellectual disabilityG Eda Utine
Hacettepe University, Department of Pediatrics, Ankara, Turkey Hacettepe University, Department of Pediatric Genetics, Ankara, Turkey Electronic address
Eur J Paediatr Neurol 18:327-37. 2014..Two separate patients had deletions in FOXP2 and UBE2A genes, respectively, for which only few patients have recently been reported...
- The plateau zokors' learning and memory ability is related to the high expression levels of foxP2 in the brainBen Yuan Ma
Department of Biology, Qinghai University, Xining 810016, China
Sheng Li Xue Bao 66:135-44. 2014..Forkhead box p2 (FOXP2) is a transcription factor implicated in the neural control of orofacial coordination and sensory-motor ..
- Brain mechanisms of acoustic communication in humans and nonhuman primates: an evolutionary perspectiveHermann Ackermann
Neurophonetics Group, Centre for Neurology General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D 72076
Behav Brain Sci 37:529-46. 2014..ii) subsequent vocal-laryngeal elaboration of cortico-basal ganglia circuitries, driven by human-specific FOXP2 mutations...
- Genetic and Developmental Perspective of Language Abnormality in Autism and Schizophrenia: One Disease Occurring at Different Ages in Humans?Haoran George Wang
Department of Psychology, University of Toronto, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Neuroscientist 22:119-31. 2016..We found many functional genes, for example, FOXP2, COMT, GABRB3, and DISC1, are actually implicated in both of them...
- Downregulation of FOXP2 promoter human hepatocellular carcinoma cell invasionXia Yan
Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China
Tumour Biol 36:9611-9. 2015..However, the mechanism underlying hepatocarcinogenesis remains unclear. Forkhead box P2 (FOXP2) has been implicated in various human cancer types. However, the role of FOXP2 in HCC remains unknown...
- Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell SubtypesMatthew L Kraushar
Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School and
J Neurosci 35:10911-26. 2015..Thalamic WNT3 regulates neocortical translation of two such mRNAs, Foxp2 and Apc, to promote FOXP2 expression while inhibiting APC expression, thereby driving neocortical neuronal ..
- Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formationMohammad Khaja Mafij Uddin
Department of Biochemistry, Hamamatsu University School of Medicine
Biomed Res 36:235-45. 2015..Our data therefore provide for a detailed understanding of the role of mesenchymal Foxc2 in aortic arch remodelling and in the development of ventricular septum. ..
- Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: A comparative analysis of the primate basal gangliaMary Ann Raghanti
Department of Anthropology, Kent State University, Kent, Ohio, 44242
J Comp Neurol 524:2117-29. 2016..uniquely human cognitive and behavioral abilities, including the association of the human-specific sequence of the FOXP2 gene with decreased dopamine in the dorsomedial striatum of mice...
- Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw developmentJeffry M Cesario
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010 United States
Gene Expr Patterns 20:111-9. 2016..of oral development, repressed the expression of the genes encoding forkhead box transcription factors, Foxp1 and Foxp2, in the oral region...
- Partial Conservation between Mice and Humans in Olfactory Bulb Interneuron Transcription Factor CodesNana Fujiwara
Burke Medical Research Institute White Plains, NY, USA
Front Neurosci 10:337. 2016..This study compared the co-expression of Foxp2, Meis2, Pax6, and Sp8 transcription factors with Calretinin, Calbindin, or Th in human and mouse OB interneurons...
- Role of miRNA-9 in Brain DevelopmentBalachandar Radhakrishnan
School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
J Exp Neurosci 10:101-120. 2016..Targeting Foxp1 and Foxp2, and Map1b by miR-9 regulates the radial migration of neurons and axonal development...
- Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac HypertrophyYuan yuan Ding
Department of Pharmacology, College of Pharmacy, Third Military Medical University Chongqing, China
Front Pharmacol 7:471. 2016..In conclusion, TP can effectively ameliorate myocardial damage and inhibit cardiac hypertrophy, which is at least partly related to the elevation of Foxp3 expression in cardiomyocytes...
- Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family memberS L Brody
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, 63110, USA
Genomics 45:509-18. 1997....
- NIH Director's Pioneer AwardERICH JARVIS; Fiscal Year: 2009..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
- Stephanie Ann White; Fiscal Year: 2016..We use songbirds to investigate FoxP2- a conserved transcription factor whose mutation causes a severe language disorder as an entry point into the ..
- FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive FunctionsGenevieve Konopka; Fiscal Year: 2010..The transcription factor FOXP2 is the only gene currently identified that is mutated in patients with isolated language disturbances, and it has ..
- Bennett G Novitch; Fiscal Year: 2014..transcription factor family are progressively expressed as motor neuron differentiation proceeds, beginning with Foxp2 in dividing progenitors, followed by Foxp4 as the cells differentiate, and then Foxp1 in subsets of postmitotic ..
- Investigating the role of CNTNAP2 gene in vocal learning in mutant songbirdsCarlos Lois; Fiscal Year: 2013..In recent years a number of genes, including the transcription factor FoxP2 and its target CNTNAP2, have been linked to language specific impairments and to ASD in humans, suggesting that ..
- Transfusion-associated immune hemolysisKarina Yazdanbakhsh; Fiscal Year: 2010..In our grant application, we will expand our animal studies to focus on the triggers that make immune cells accept or reject transfused blood. ..
- JERALD MICHAEL BOWERS; Fiscal Year: 2014..Moreover, the gene FOXP2 is known to be expressed in several areas of the brain involved in vocal communication in animals and language in ..
- Transcriptional Regulation of Myogenic Stem CellsDaniel J Garry; Fiscal Year: 2013..This proposal will decipher the molecular pathways that govern muscle stem cells and may ultimately lead to novel therapies directed towards an enhanced regenerative response in patients with myopathic diseases. ..
- Sudha K Iyengar; Fiscal Year: 2016..A decade ago, identification of a highly penetrant, discrete genetic variant in FOXP2 in a single family was the first step for the field of speech and language disorders...
- FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive FunctionsGenevieve Konopka; Fiscal Year: 2013..mouse brain, and 3) Ascertain how Fdxp2 and Foxpl cooperatively regulate gene expression during CNS development by generating Foxpl conditional knockout mice and conducting genome wide Foxp2 promoter binding analysis.
- FoxP3 as the X-Linked Breast Cancer Suppressor GeneYang Liu; Fiscal Year: 2010....
- Neurogenomics in a Model for Procedural LearningAUSTIN HILLIARD; Fiscal Year: 2010DESCRIPTION (provided by applicant): FoxP2 is currently the only molecule directly linked to a developmental onset human speech and language disorder...
- Characterization and Genetic Analysis of Basal Ganglia Axon PathfindingJOSH LEITCH BONKOWSKY; Fiscal Year: 2013..pathfinding, I have generated novel enhancer lines specific for basal ganglia neurons, including dlx(mini):gfp and foxP2-enhancerA:egfp. Aim 2...
- DEVELOPMENT OF SYNAPTIC INPUTS ON SPINAL INTERNEURONSFrancisco J Alvarez; Fiscal Year: 2013..Thus, we divided V1s in an early generated group (that includes Renshaw cells and lack expression of FoxP2) and a late generated group (that includes IaINs and are FoxP2+)...
- The role of stress and FoxP2 in adult vocal learning: tests using a parrot modelTimothy F Wright; Fiscal Year: 2013..the primary stress hormone in birds) on learning in juveniles and adults, and iii) the role of the gene FoxP2 in learning in juveniles and adults...
- The Role of FoxP2 in Olfactory Bulb Interneuron NeurogenesisZegary J Allen; Fiscal Year: 2010..In this study I aim to determine the role of the recently identified winged helix/forkhead transcription factor Foxp2 in the generation of olfactory bulb interneurons...
- Foxp2 and vocal communication: a new mammalian modelPolly Campbell; Fiscal Year: 2009..We focus on the expression and function of Foxp2, a gene implicated in both the evolution of human language and the genesis of human communicative disorders...
- Identification of targets of FoxP2 in the brainDaniel Geschwind; Fiscal Year: 2006..Recently a mutation in the FOXP2 gene was identified in a family with a speech and language development disorder including orofacial dyspraxia and ..
- Structure and Function of the FOXP Family of Transcription FactorsLin Chen; Fiscal Year: 2009..Mutations in FOXP proteins have been linked to human autoimmune disease (FOXP3) and speech disorder (FOXP2). Other members of the FOXP family have been implicated in tumor suppression (FOXP1) and lung development (FOXP4)...
- Role of the Foxn4 Gene during RetinogenesisMengqing Xiang; Fiscal Year: 2007..abstract_text> ..
- Role of FoxP2 in AEC (trans)differentiationZea Borok; Fiscal Year: 2008..b>FoxP2 is the only member of the Fox family of transcription factors (TF) that is exclusively expressed in distal lung ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- The Genetics of Specific Language ImpairmentJAMES TOMBLIN; Fiscal Year: 2009..speech and language impairment, who also have a chromosomal translocation that appears to involve the FOXP2 gene. The FOXP2 gene is known to be a regulatory gene implicated in developmental speech and language disorder...
- Identifying human adaptations: theory and applicationsMolly Przeworski; Fiscal Year: 2009..Thus, the proposed research will generate new statistical tools for the detection of regions of functional importance and will identify the first set of candidates for human-specific adaptations in gene expression regulation. ..
- De novo induction of Foxp3+ regulatory T cells in tumor microenvironmentF XIAOFENG QIN; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MOLECULAR GENETICS OF AUTISMThomas Wassink; Fiscal Year: 2006..The WNT2 findings will be further examined in two-independent patient samples. ..
- A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENESThomas Wassink; Fiscal Year: 2004..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
- Evolution of vertebrate sensory genesJianzhi Zhang; Fiscal Year: 2010..These studies will also help understand human smell and taste variations and disorders. ..
- Genetic Determinants of Brain Structure and Disease Risk in SchizophreniaThomas H Wassink; Fiscal Year: 2010....
- Collaboration on Specific Language ImpairmentJAMES TOMBLIN; Fiscal Year: 2005..abstract_text> ..