FMNL2

Summary

Gene Symbol: FMNL2
Description: formin like 2
Alias: FHOD2, formin-like protein 2, formin homology 2 domain containing 2, formin homology 2 domain-containing protein 2
Species: human

Top Publications

  1. ncbi Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1161-8. 2003
  2. doi Overexpression of FMNL2 is closely related to metastasis of colorectal cancer
    Xi ling Zhu
    Department of Pathology, Southern Medical University, Guangzhou 510515 Guangdong Province, China
    Int J Colorectal Dis 23:1041-7. 2008
  3. pmc MicroRNA-613 targets FMNL2 and suppresses progression of colorectal cancer
    Bai Li
    Department of Colorectal and Anal Surgery, The First Hospital of Jilin University Changchun 130021, P R China
    Am J Transl Res 8:5475-5484. 2016
  4. pmc Critical roles for multiple formins during cardiac myofibril development and repair
    Michelle Rosado
    Biology Department and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454
    Mol Biol Cell 25:811-27. 2014
  5. pmc The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation
    Sonja Kuhn
    1 Center of Advanced European Studies and Research, Group Physical Biochemistry, Ludwig Erhard Allee 2, Bonn 53175, Germany 2 Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, Dortmund 44227, Germany
    Nat Commun 6:7088. 2015
  6. pmc Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1
    Katharina Grikscheit
    Institute of Pharmacology, Biochemical Pharmacological Center BPC, University of Marburg, 35032 Marburg, Germany
    J Cell Biol 209:367-76. 2015
  7. doi MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer
    Guifeng Lu
    Department of Pathology, Southern Medical University, Guangzhou City 510515, Guangdong Province, People s Republic of China Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou 510515, Guangdong Province, People s Republic of China
    Exp Mol Pathol 99:173-9. 2015
  8. doi Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα
    Ying Wang
    Institute of Pharmacology, University of Marburg, 35043 Marburg, Germany
    Dev Cell 34:475-83. 2015
  9. pmc Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer
    Yuanfeng Zeng
    Department of Pathology, Southern Medical University, Guangzhou, China
    Cancer Sci 106:1385-93. 2015
  10. doi Expression of multiple formins in adult tissues and during developmental stages of mouse brain
    Priyanka Dutta
    Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246 Nadia, West Bengal, India Electronic address
    Gene Expr Patterns 19:52-9. 2015

Scientific Experts

  • M Katoh
  • Priyanka Dutta
  • Helle Lybaek
  • Maria Gardberg
  • Wilko Thiele
  • Li Liang
  • Xi ling Zhu
  • Yan qing Ding
  • Xiaoli Ren
  • Sonja Kuhn
  • Yanqing Ding
  • Yuanfeng Zeng
  • Huijun Xie
  • Guifeng Lu
  • Ying Wang
  • Wenting Liao
  • Jennifer Block
  • Jianmei Wang
  • Xiaojing Zhang
  • X L Ren
  • J Y Wang
  • Christine Péladeau
  • Bai Li
  • Ellen V S Hessel
  • Qingjun Meng
  • SaiNan Xin
  • Robert Grosse
  • Shashank Shekhar
  • Qian Wu
  • Katharina Grikscheit
  • Yuling Li
  • Guoyang He
  • Michelle Rosado
  • Klemens Rottner
  • Frieda Kage
  • Matthias Geyer
  • Xiling Zhu
  • Xianzheng Li
  • Koko Moriya
  • Jian Guan
  • Yufa Li
  • T M Kitzing
  • Yuriko Katoh
  • Marian J A Groot Koerkamp
  • Z H Li
  • Yuan Lin
  • X M Li
  • Zhicheng Zeng
  • B Wang
  • Frank C P Holstege
  • G Y He
  • Allan Heibein
  • Shaoshan Yang
  • John W Copeland
  • Y L Li
  • Z M Chen
  • Q Feng
  • Sarah J Copeland
  • Y Q Ding
  • Hui Men
  • P X Wu
  • Bo Li
  • Cathy Fernandes
  • Melissa T Maltez
  • M Ye
  • L Liu
  • Yanguang Li
  • Zhongshi Xie
  • X S Ye
  • L Liang
  • Martien J H Kas
  • S N Xin
  • Hein A van Lith
  • L Z Yi
  • Zhihong Li
  • Mingming Ren
  • Xiaoliang Lan
  • G F Lu
  • Xiang Song
  • W T Liao
  • Pierre N E de Graan
  • J Yao
  • Marina de Wit
  • Z G Wu
  • Inge G Wolterink-Donselaar
  • Si Chen
  • Yudan Qiao
  • Shengli An
  • Mikael Kerleau
  • Gert Bange

Detail Information

Publications40

  1. ncbi Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1161-8. 2003
    ..9 (nucleotide position 100576-125849, forward orientation). FMNL2 gene, corresponding to KIAA1902 and FHOD2 cDNAs, was located within NT_005151...
  2. doi Overexpression of FMNL2 is closely related to metastasis of colorectal cancer
    Xi ling Zhu
    Department of Pathology, Southern Medical University, Guangzhou 510515 Guangdong Province, China
    Int J Colorectal Dis 23:1041-7. 2008
    Formin-like 2 (FMNL2) is a member of diaphanous-related formins which can control the actin-dependent processes such as cell motility and invasion...
  3. pmc MicroRNA-613 targets FMNL2 and suppresses progression of colorectal cancer
    Bai Li
    Department of Colorectal and Anal Surgery, The First Hospital of Jilin University Changchun 130021, P R China
    Am J Transl Res 8:5475-5484. 2016
    ..quantitative PCR (qPCR) and western blot techniques were used to assess expression of miR-613 and formin-like 2 (FMNL2) in CRC cell lines and tissues...
  4. pmc Critical roles for multiple formins during cardiac myofibril development and repair
    Michelle Rosado
    Biology Department and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454
    Mol Biol Cell 25:811-27. 2014
    ..Using RNA interference silencing, we find that the formins mDia2, DAAM1, FMNL1, and FMNL2 are required nonredundantly for myofibrillogenesis...
  5. pmc The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation
    Sonja Kuhn
    1 Center of Advanced European Studies and Research, Group Physical Biochemistry, Ludwig Erhard Allee 2, Bonn 53175, Germany 2 Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, Dortmund 44227, Germany
    Nat Commun 6:7088. 2015
    ..The crystal structures of the N-terminal domains of human FMNL1 and FMNL2 in complex with active Cdc42 show that Cdc42 mediates contacts with all five armadillo repeats of the formin with ..
  6. pmc Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1
    Katharina Grikscheit
    Institute of Pharmacology, Biochemical Pharmacological Center BPC, University of Marburg, 35032 Marburg, Germany
    J Cell Biol 209:367-76. 2015
    ..We identify formin-like 2 (FMNL2) as being specifically required for actin assembly and turnover at newly formed cell-cell contacts as well as for ..
  7. doi MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer
    Guifeng Lu
    Department of Pathology, Southern Medical University, Guangzhou City 510515, Guangdong Province, People s Republic of China Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou 510515, Guangdong Province, People s Republic of China
    Exp Mol Pathol 99:173-9. 2015
    ..Moreover, ectopic miR-34a suppressed tumor growth and metastasis of CRC cells in vivo. FMNL2 and E2F5 were identified as direct targets of miR-34a...
  8. doi Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα
    Ying Wang
    Institute of Pharmacology, University of Marburg, 35043 Marburg, Germany
    Dev Cell 34:475-83. 2015
    ..Here, we uncover formin-like 2 (FMNL2) as a critical regulator of β1-integrin internalization downstream of protein kinase C (PKC)...
  9. pmc Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer
    Yuanfeng Zeng
    Department of Pathology, Southern Medical University, Guangzhou, China
    Cancer Sci 106:1385-93. 2015
    Formin-like2 (FMNL2) is a member of the diaphanous-related formins family, which act as effectors and upstream modulators of Rho GTPases signaling and control the actin-dependent processes, such as cell motility or invasion...
  10. doi Expression of multiple formins in adult tissues and during developmental stages of mouse brain
    Priyanka Dutta
    Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246 Nadia, West Bengal, India Electronic address
    Gene Expr Patterns 19:52-9. 2015
    ..Expression of FMNL2 and Fhdc1 are high in adult mouse brain as compare to embryonic stages...
  11. pmc Analysis of the miRNA-mRNA-lncRNA networks in ER+ and ER- breast cancer cell lines
    Qian Wu
    The State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    J Cell Mol Med 19:2874-87. 2015
    ..In the co-expression networking, CD74 and FMNL2 gene which is involved in the immune response and metastasis, respectively, had a stronger correlation with ER...
  12. doi MicroRNA-206 functions as a tumor suppressor in colorectal cancer by targeting FMNL2
    X L Ren
    Department of Pathology, Southern Medical University, Guangzhou City, 510515, Guangdong Province, People s Republic of China
    J Cancer Res Clin Oncol 142:581-92. 2016
    ..MicroRNAs play important roles in the progression of CRC. This study aimed to investigate the role of miR-206 and its novel mechanism in the invasion and metastasis of CRC...
  13. pmc Formin and capping protein together embrace the actin filament in a ménage à trois
    Shashank Shekhar
    Cytoskeleton Dynamics and Cell Motility, Department of Biochemistry, Biophysics and Structural Biology, I2BC, CNRS, 91198 Gif sur Yvette, France
    Nat Commun 6:8730. 2015
    ..Their mutually weakened binding enables rapid displacement of one by the other. We show that formin FMNL2 behaves similarly, thus suggesting that this is a general property of formins...
  14. pmc Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer
    Huijun Xie
    Department of Pathology, Nanfang Hospital, Guangzhou, Guangdong, China
    Oncotarget 7:26680-91. 2016
    ..hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC tissues, circ_001569 negatively correlated with miR-145, and miR-145 correlated negatively with E2F5, BAG4 ..
  15. pmc FMNL2/FMNL3 formins are linked with oncogenic pathways and predict melanoma outcome
    Maria Gardberg
    Department of Pathology University of Turku and Turku University Hospital Turku Finland
    J Pathol Clin Res 2:41-52. 2016
    ..Here, we studied formin-like protein 2 and 3 (FMNL2 and FMNL3) in melanoma by analysing their role in the invasive properties of melanoma cells and by evaluating ..
  16. pmc A specific FMNL2 isoform is up-regulated in invasive cells
    Christine Péladeau
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada
    BMC Cell Biol 17:32. 2016
    ..In particular, increased FMNL2 expression correlates with increased invasiveness of colorectal cancer (CRC) in vivo and for a variety of CRC cell-..
  17. doi Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a
    Ellen V S Hessel
    Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Neurosci 44:2950-2957. 2016
    ..2). FS-QTL2a contained 44 genes expressed in the brain at post natal day 14. Four of these (Arl6ip6, Cytip, Fmnl2 Ifih1) contained a non-synonymous SNP comparing CSS2 and C57BL/6J, six genes (March7, Nr4a2, Gpd2, Grb14, Scn1a, ..
  18. doi Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models
    J Y Wang
    Department of General Surgery, Shenzhen Children s Hospital, Shenzhen, Guangdong Province, China
    Genet Mol Res 15:. 2016
    ..EMT-related protein (formin-like 2, FMNL2; E-cadherin; vimentin; and cytokeratin-19, CK-19) expression was analyzed by western blot and immunofluorescent ..
  19. pmc LncRNA-RMRP Acts as an Oncogene in Lung Cancer
    Qingjun Meng
    Department of Thoracic Surgery, Cangzhou Central Hospital, Cangzhou, Hebei, China
    PLoS ONE 11:e0164845. 2016
    ..In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206...
  20. pmc FMNL2 drives actin-based protrusion and migration downstream of Cdc42
    Jennifer Block
    Institute of Genetics, University of Bonn, Karlrobert Kreiten Strasse 13, 53115 Bonn, Germany
    Curr Biol 22:1005-12. 2012
    ..Here we show that the Diaphanous-related formin FMNL2, also known as FRL3 or FHOD2, accumulates at lamellipodia and filopodia tips...
  21. doi MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2
    Li Liang
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, PR China
    Gastroenterology 144:624-635.e4. 2013
    ..We investigated whether microRNAs regulate levels of FMNL2 in colorectal cancer (CRC) cells.
  22. ncbi Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3
    Koko Moriya
    Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Biosci Biotechnol Biochem 76:1201-9. 2012
    ..However, two proteins, formin-like2 (FMNL2) and formin-like3 (FMNL3), both of them are members of the formin family of proteins, were associated mainly with ..
  23. ncbi [Expression of FMNL2 and its relation to the metastatic potential of human colorectal cancer cells]
    Xi ling Zhu
    Department of Pathology, Southern Medical University, Guangzhou 510515, China zmgw fimmu com
    Nan Fang Yi Ke Da Xue Xue Bao 28:1775-8. 2008
    To explore the association of FMNL2 expression with the metastatic potential of colorectal cancer cells.
  24. ncbi Identification and characterization of human DAAM2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:915-20. 2003
    ..Among Formin-homology proteins, FDD (Formin-like, Diaphanous, Daam) domain was conserved in FMNL1/FMNL/KW-13, FMNL2/KIAA1902/FHOD2, DIAPH1, DIAPH2, DAAM1 and DAAM2, but not in Fmn1, Fmn2, FHOD1 and Grid2ip...
  25. ncbi Identification and characterization of human FNBP3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:651-6. 2003
    FMNL1, FMNL2, FMNL3, DAAM1, DAAM2, DIAPH1 and DIAPH2 constitute the Formin-homology subfamily with FDD, FH1 and FH2 domains. FMNL2 gene is linked to FNBP3 (also known as HYPA) gene on human chromosome 2q23...
  26. ncbi Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:1015-9. 2003
    ..FMNL1/KW-13/FMNL, FMNL2/KIAA1902/FHOD2, FMNL3/KIAA2014, DAAM1, DAAM2, DIAPH1 and DIAPH2 are Formin-homology proteins with the FDD domain, while Fmn1, ..
  27. ncbi Identification and characterization of human DIAPH3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:473-8. 2004
    ..3% total-amino-acid identity with DIAPH1, and 57.3% total-amino-acid identity with DIAPH2. FMNL1/FMNL, FMNL2/FHOD2, FMNL3/WBP3, DAAM1, DAAM2, DIAPH1, DIAPH2 and DIAPH3 were classified as the FDD-type Formin homology ..
  28. ncbi Identification and characterization of human FHOD3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:615-20. 2004
    ..FHOD1/FHOS, GRID2IP, Fmn1 and Fmn2 are non-FDD-type Formin homology proteins, while FMNL1, FMNL2/FHOD2, FMNL3, DAAM1, DAAM2, DIAPH1, DIAPH2 and DIAPH3 are FDD-type Formin homology proteins...
  29. ncbi Identification and characterization of human FHDC1, mouse Fhdc1 and zebrafish fhdc1 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:929-34. 2004
    ..FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2 are FDD-type Formin homology proteins, while FHOD1, FHOD3, GRID2IP,..
  30. ncbi Identification and characterization of the human FMN1 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:121-6. 2004
    ..Fmn1, Fmn2, FHOD1, FHOD3, GRID2IP and FHDC1 are non-FDD-type Formin homology proteins, while FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2 are FDD-type Formin homology proteins...
  31. ncbi Characterization of FMN2 gene at human chromosome 1q43
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:469-74. 2004
    ..FMN1, FHOD1, FHOD3, GRID2IP and FHDC1 are non-FDD-type Formin homology proteins, while FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2 are FDD-type Formin homology proteins...
  32. ncbi Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Oncol Rep 12:939-43. 2004
    ..cerevisiae homolog of human Formin-homology proteins, such as FMN1, FMN2, FHOD1, FHOD3, FHDC1, GRID2IP, FMNL1, FMNL2, FMNL3, DIAPH1, DIAPH2, DIAPH3, DAAM1 and DAAM2...
  33. pmc An 8.9 Mb 19p13 duplication associated with precocious puberty and a sporadic 3.9 Mb 2q23.3q24.1 deletion containing NR4A2 in mentally retarded members of a family with an intrachromosomal 19p-into-19q between-arm insertion
    Helle Lybaek
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Helse Bergen HF, Norway
    Eur J Hum Genet 17:904-10. 2009
    ..9-Mb deletion of 2q23.3q24.1. This novel microdeletion involves seven genes, of which FMNL2, a suggested regulator of Rho-GTPases, and NR4A2, an essential gene for differentiation of dopaminergic neurons, ..
  34. doi Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
    T M Kitzing
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    Oncogene 29:2441-8. 2010
    ..Importantly, by knocking down all Rho proteins, we identified formin-like 2 (FMNL2) as a specific RhoC effector, showing selective interaction of FMNL2 with active RhoC, but not RhoA or RhoB...
  35. pmc Characterization of Diaphanous-related formin FMNL2 in human tissues
    Maria Gardberg
    Department of Pathology, University of Turku and Turku University Central Hospital, Turku, Finland
    BMC Cell Biol 11:55. 2010
    ..In spite of this, very little is known of the tissue distribution and cellular location of any mammalian formin. Here we have carried out a comprehensive analysis of the formin family member formin -like 2 (FMNL2) in human tissues.
  36. doi FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition
    Yufa Li
    Department of Pathology, School of Basic Medical Sciences, Southern Medical University, 1838, North Guangzhou Street, Baiyun Region, Guangzhou 510515, Guangdong Province, People s Republic of China
    Mol Cancer Res 8:1579-90. 2010
    b>FMNL2 is a member of diaphanous-related formins that control actin-dependent processes such as cell motility and invasion...
  37. doi Down-regulation of formin-like 2 predicts poor prognosis in hepatocellular carcinoma
    Li Liang
    Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, People s Republic of China
    Hum Pathol 42:1603-12. 2011
    ..Our results suggest that formin-like 2 is a valuable marker for the progression of hepatocellular carcinoma. Down-regulation is associated with poor overall survival...
  38. doi FMNL2 is a positive regulator of cell motility and metastasis in colorectal carcinoma
    Xi ling Zhu
    Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, People s Republic of China
    J Pathol 224:377-88. 2011
    b>FMNL2 is a member of diaphanous-related formins which act as effectors of Rho family GTPases and control the actin-dependent processes such as cell motility or invasion...
  39. doi Discovery of a novel tumour metastasis-promoting gene, NVM-1
    Wilko Thiele
    University of Heidelberg, Medical Faculty Mannheim, Germany KIT Campus Nord, Institut für Toxikologie und Genetik, Karlsruhe, Germany
    J Pathol 225:96-105. 2011
    ..Up-regulation of FMNL2 and MT1E and down-regulation of TIMP4 and MHC-I is observed as a consequence of NVM-1 expression...
  40. ncbi Sequence identification of 2,375 human brain genes
    M D Adams
    Receptor Biochemistry and Molecular Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Nature 355:632-4. 1992
    ..These data represent an approximate doubling of the number of human genes identified by DNA sequencing and may represent as many as 5% of the genes in the human genome...