FLG

Summary

Gene Symbol: FLG
Description: filaggrin
Alias: ATOD2, filaggrin, epidermal filaggrin
Species: human

Top Publications

  1. doi Clinical severity correlates with impaired barrier in filaggrin-related eczema
    Ikue Nemoto-Hasebe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Invest Dermatol 129:682-9. 2009
  2. ncbi Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
    Frances J D Smith
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 38:337-42. 2006
  3. doi Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth
    Klaus Bønnelykke
    Copenhagen Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    Pediatr Allergy Immunol 21:954-61. 2010
  4. ncbi Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
    Aileen Sandilands
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 39:650-4. 2007
  5. doi Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis
    Ek Greisenegger
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria
    J Eur Acad Dermatol Venereol 24:607-10. 2010
  6. ncbi Filaggrin null alleles are not associated with hand eczema or contact allergy
    A Lerbaek
    National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Ledreborg Alle 40, 1, 2820 Gentofte, Denmark
    Br J Dermatol 157:1199-204. 2007
  7. ncbi Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis
    Susanne Stemmler
    J Invest Dermatol 127:722-4. 2007
  8. doi Filaggrin loss-of-function mutations and association with allergic diseases
    Elke Rodriguez
    Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Muenchen, Neuherberg and ZAUM Center for Allergy and Environment, Technical University Munich, Biedersteiner Str 29, 80802 Munich, Germany
    Pharmacogenomics 9:399-413. 2008
  9. doi Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 122:560-8.e4. 2008
  10. ncbi Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus
    R B Presland
    Department of Oral Biology, University of Washington, Seattle 98195
    J Biol Chem 267:23772-81. 1992

Research Grants

  1. DENNIS ROOP; Fiscal Year: 2015
  2. Nature of mamalian Cutaneous Permeablilty Barrier
    Peter M Elias; Fiscal Year: 2012
  3. Filaggrin Mutations and the Prognosis of Atopic Dermatitis
    David J Margolis; Fiscal Year: 2013
  4. Mark H Kaplan; Fiscal Year: 2016
  5. ENDOTHELIAL CELLS AND OSTEOCLAST DEVELOPMENT
    Patricia Collin Osdoby; Fiscal Year: 1999
  6. GENES CONTROLLING PIGMENTATION
    Ruth Halaban; Fiscal Year: 1999
  7. FLAGELLAR REGULATION AND SALMONELLA VIRULENCE
    ALISON O BRIEN; Fiscal Year: 2000
  8. CELL SURFACE AND OSTEOCLAST DEVELOPMENT
    Philip Osdoby; Fiscal Year: 2000
  9. Genetic Studies of Immune Responsiveness to Cockroach
    Kathleen Barnes; Fiscal Year: 2007
  10. AIRWAY DISEASE AND COCKROACH EXPOSURE IN PUBLIC HOUSING
    Kathleen Barnes; Fiscal Year: 2008

Detail Information

Publications215 found, 100 shown here

  1. doi Clinical severity correlates with impaired barrier in filaggrin-related eczema
    Ikue Nemoto-Hasebe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Invest Dermatol 129:682-9. 2009
    Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function, have been shown to be a major predisposing factor for atopic dermatitis (AD; eczema)...
  2. ncbi Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
    Frances J D Smith
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 38:337-42. 2006
    ..We have identified homozygous or compound heterozygous mutations R501X and 2282del4 in the gene encoding filaggrin (FLG) as the cause of moderate or severe ichthyosis vulgaris in 15 kindreds...
  3. doi Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth
    Klaus Bønnelykke
    Copenhagen Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    Pediatr Allergy Immunol 21:954-61. 2010
    ..in Childhood (COPSAC) was one of the discovery cohorts of the association between eczema and variants in the filaggrin coding gene (FLG)...
  4. ncbi Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
    Aileen Sandilands
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 39:650-4. 2007
    We recently reported two common filaggrin (FLG) null mutations that cause ichthyosis vulgaris and predispose to eczema and secondary allergic diseases...
  5. doi Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis
    Ek Greisenegger
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria
    J Eur Acad Dermatol Venereol 24:607-10. 2010
    Recently, mutations in the filaggrin gene (FLG) have been shown to be a major predisposing factor for atopic dermatitis (AD).
  6. ncbi Filaggrin null alleles are not associated with hand eczema or contact allergy
    A Lerbaek
    National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Ledreborg Alle 40, 1, 2820 Gentofte, Denmark
    Br J Dermatol 157:1199-204. 2007
    The filaggrin protein is a key component of stratum corneum and homo- or heterozygotes for the filaggrin variant alleles R501X and 2282del4 have varying degrees of impaired skin barrier...
  7. ncbi Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis
    Susanne Stemmler
    J Invest Dermatol 127:722-4. 2007
  8. doi Filaggrin loss-of-function mutations and association with allergic diseases
    Elke Rodriguez
    Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Muenchen, Neuherberg and ZAUM Center for Allergy and Environment, Technical University Munich, Biedersteiner Str 29, 80802 Munich, Germany
    Pharmacogenomics 9:399-413. 2008
    ..Recently, attention has been drawn to the protein filaggrin, an integral part of the epidermis that plays a key role in engineering and maintaining the barrier function...
  9. doi Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 122:560-8.e4. 2008
    ..These genes encode proteins thought to be involved in the regulation of posttranslation processing of filaggrin (FLG), the strongest identified genetic risk factor for eczema to date.
  10. ncbi Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus
    R B Presland
    Department of Oral Biology, University of Washington, Seattle 98195
    J Biol Chem 267:23772-81. 1992
    b>Filaggrin is an intermediate filament-associated protein which functions to aggregate keratin intermediate filaments in the stratum corneum of mammalian epidermis...
  11. ncbi Organization, structure, and polymorphisms of the human profilaggrin gene
    S Q Gan
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Biochemistry 29:9432-40. 1990
    ..as a large polyprotein precursor and is subsequently proteolytically processed into individual functional filaggrin molecules. We have isolated genomic DNA and cDNA clones encoding the 5'- and 3'-ends of the human gene and mRNA...
  12. ncbi Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules
    V P Sybert
    J Invest Dermatol 84:191-4. 1985
    ..The basic defect in ichthyosis vulgaris is unknown. We have tested for the presence of filaggrin and its precursor, profilaggrin, in the epidermis of affected and unaffected individuals from 2 families with ..
  13. pmc Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21
    L J McKinley-Grant
    Dermatology Branch, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 86:4848-52. 1989
    ..We have isolated a cDNA clone encoding human filaggrin and used this to demonstrate that the human gene encodes a polyprotein precursor containing numerous tandem ..
  14. pmc Profilaggrin is a major epidermal calcium-binding protein
    N G Markova
    Skin Biology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892
    Mol Cell Biol 13:613-25. 1993
    ..It contains 10 to 12 tandemly repeated filaggrin units and is processed into the intermediate filament-associated protein filaggrin by specific dephosphorylation ..
  15. ncbi Filaggrin repeat number polymorphism is associated with a dry skin phenotype
    Rebecca S Ginger
    Unilever R and D Colworth, Sharnbrook, Beds, MK44 1LQ, UK
    Arch Dermatol Res 297:235-41. 2005
    ..by a gene located in the epidermal differentiation complex of Chromosome 1q21 and is composed of multiple filaggrin repeats connected by highly conserved linker peptides...
  16. ncbi Skin barrier function and allergic risk
    Thomas J Hudson
    Nat Genet 38:399-400. 2006
  17. ncbi Filaggrin null alleles are not associated with psoriasis
    Yiwei Zhao
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    J Invest Dermatol 127:1878-82. 2007
    ..It has recently been shown in several replicate studies that prevalent null alleles for the filaggrin gene (FLG) on 1q21 are an important genetic factor in AD...
  18. ncbi Loss-of-function mutations in the filaggrin gene: no contribution to disease susceptibility, but to autoantibody formation against citrullinated peptides in early rheumatoid arthritis
    U Huffmeier
    Institute of Human Genetics, University Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 67:131-3. 2008
    Autoantibody formation to citrullinated (pro)filaggrin has proven to be a highly specific serological marker for rheumatoid arthritis (RA)...
  19. ncbi The filaggrin story: novel insights into skin-barrier function and disease
    John A McGrath
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, The Guy s, King s College and St Thomas School of Medicine, London, UK
    Trends Mol Med 14:20-7. 2008
    Recent reports have uncovered the key role of the protein filaggrin in maintaining an effective skin barrier against the external environment...
  20. doi Association between P478S polymorphism of the filaggrin gene and risk of psoriasis in a Chinese population in Taiwan
    Ya Ching Chang
    Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Arch Dermatol Res 300:133-7. 2008
    Abnormal keratinocyte terminal differentiation is one of the important characteristics of psoriatic lesions. Filaggrin (FLG) is a key protein that facilitates the terminal differentiation of the epidermis...
  21. doi Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan
    Toshifumi Nomura
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Invest Dermatol 128:1436-41. 2008
    Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of ichthyosis vulgaris (IV) and shown to be major predisposing factors for atopic dermatitis (AD)...
  22. doi Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population
    Sebastian Müller
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 20:358-61. 2009
    ..Two loss of function polymorphisms FLG R501X- and 2282del4, in the Filaggrin (FLG) gene encoding for an epidermal barrier protein were recently identified...
  23. doi Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations
    R Gruber
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Br J Dermatol 161:1391-5. 2009
    ..Loss-of-function mutations in the filaggrin (FLG) gene underlie the most prevalent skin disorder of cornification, ichthyosis vulgaris (IV), which presents ..
  24. doi Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure
    M L A Schuttelaar
    Departments of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Allergy 64:1758-65. 2009
    b>Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear.
  25. doi FLG mutations in ichthyosis vulgaris and atopic eczema: spectrum of mutations and population genetics
    M Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Br J Dermatol 162:472-7. 2010
    b>Filaggrin is a key protein involved in skin barrier function...
  26. pmc Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations
    Gráinne M O'Regan
    Department of Paediatric Dermatology, Our Lady s Children s Hospital, Crumlin, Dublin, Ireland
    J Allergy Clin Immunol 125:170-4.e1-2. 2010
    ..The genetic basis is incompletely understood; however, loss of function mutations in the filaggrin gene (FLG) are the most significant and widely replicated genetic risk factor reported to date...
  27. doi Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema
    J M Jungersted
    Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
    Allergy 65:911-8. 2010
    Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in ..
  28. doi Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study
    J P Thyssen
    Department of Dermato Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Br J Dermatol 163:115-20. 2010
    Hand eczema is prevalent in the general population. It remains unclear whether or not filaggrin gene (FLG) null mutations increase the overall risk of hand eczema or only increase the risk of hand eczema in subjects with atopic dermatitis.
  29. doi Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus
    Claudia Cramer
    IUF Institut für Umweltmedizinische Forschung, Dusseldorf, Germany
    J Allergy Clin Immunol 125:1254-1260.e5. 2010
    ..Especially barrier disturbances as found in children with mutations in the filaggrin gene (FLG) seem to play an important role.
  30. pmc Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes
    Gráinne M O'Regan
    National Children s Research Centre, Our Lady s Children s Hospital, Dublin, Ireland
    J Allergy Clin Immunol 126:574-80.e1. 2010
    b>Filaggrin (FLG) has a central role in the pathogenesis of atopic dermatitis (AD). FLG is a complex repetitive gene; highly population-specific mutations and multiple rare mutations make routine genotyping complex...
  31. doi Lower prevalence of common filaggrin mutations in a community sample of atopic eczema: is disease severity important?
    Robert Gruber
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Wien Klin Wochenschr 122:551-7. 2010
    Recent studies have shown an association of loss-of-function mutations in the filaggrin gene (FLG) with ichthyosis vulgaris and atopic eczema (AE)...
  32. pmc Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity
    S Kezic
    Coronel Institute of Occupational Health, Academic Medical Center, Amsterdam, The Netherlands
    Allergy 66:934-40. 2011
    b>Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA)...
  33. pmc Filaggrin gene defects are independent risk factors for atopic asthma in a Polish population: a study in ECAP cohort
    Joanna Ponińska
    Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland
    PLoS ONE 6:e16933. 2011
    b>FLG null variants of which 2282del4 and R501X are the most frequent in Caucasians are established risk factors for atopic dermatitis (AD) with an effect probably mediated through impairment of epidermal barrier...
  34. pmc Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency
    Sanja Kezic
    Coronel Institute of Occupational Health, Academic Medical Center, Amsterdam, The Netherlands
    J Allergy Clin Immunol 129:1031-9.e1. 2012
    b>Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH...
  35. ncbi Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci
    W O Cookson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 27:372-3. 2001
    ..These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity...
  36. ncbi Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
    Colin N A Palmer
    Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 38:441-6. 2006
    ..b>Filaggrin is a key protein that facilitates terminal differentiation of the epidermis and formation of the skin barrier...
  37. ncbi Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
    J Allergy Clin Immunol 118:214-9. 2006
    ..One of the characteristic features of AD and causative factor for the disease is an impaired epidermal skin barrier based on a primary defect of epidermal differentiation...
  38. ncbi Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood
    Jonathan N W N Barker
    St John s Institute of Dermatology, King s College London, St Thomas s Hospital, London, UK
    J Invest Dermatol 127:564-7. 2007
    ..We have recently shown that null mutations in the filaggrin gene (FLG) are an important predisposing factor for childhood eczema and eczema-associated asthma, but ..
  39. ncbi Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis
    Stephan Weidinger
    J Invest Dermatol 127:724-6. 2007
  40. ncbi Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis
    Toshifumi Nomura
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Allergy Clin Immunol 119:434-40. 2007
    b>Filaggrin is a key protein involved in skin barrier function...
  41. ncbi Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis
    Aileen Sandilands
    Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Dundee, UK
    J Invest Dermatol 127:1282-4. 2007
    Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema)...
  42. ncbi Loss-of-function mutations in the filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients comorbid for atopic disease
    Regina C Betz
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Invest Dermatol 127:2539-43. 2007
    ..Association of AA with atopic disease has been repeatedly reported. Loss-of-function mutations in the filaggrin gene (FLG) may be considered as promising candidates in AA, as they have been observed to be a strong risk ..
  43. ncbi Filaggrin mutations are genetic modifying factors exacerbating X-linked ichthyosis
    Haihui Liao
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    J Invest Dermatol 127:2795-8. 2007
    ..Owing to the high population frequency of FLG mutations, filaggrin is a possible genetic modifier in other genodermatoses.
  44. ncbi Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data
    Hansjörg Baurecht
    Institute for Medical Statistics and Epidemiology IMSE, Technical University Munich TUM, Munich, Germany
    J Allergy Clin Immunol 120:1406-12. 2007
    With an impressive series of replication studies, filaggrin (FLG) has become the gene with the most widely replicated association to atopic eczema (AE)...
  45. ncbi Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort
    Thomas Hubiche
    Service de Dermatologie, CHU Bordeaux, Hôpital Saint André, France
    Acta Derm Venereol 87:499-505. 2007
    ..A functional relevance has already been established for filaggrin variants, but not for SPINK5 and KLK7 polymorphisms...
  46. ncbi De novo occurrence of the filaggrin mutation p.R501X with prevalent mutation c.3321delA in a Japanese family with ichthyosis vulgaris complicated by atopic dermatitis
    Takahiro Hamada
    J Invest Dermatol 128:1323-5. 2008
  47. ncbi R501X and 2282del4 filaggrin mutations do not confer susceptibility to psoriasis and atopic dermatitis in Italian patients
    Emiliano Giardina
    Dermatology 216:83-4. 2008
  48. ncbi Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:1430-5. 2008
    ..b>Filaggrin is crucial for the maintenance of the skin barrier function...
  49. ncbi Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma
    Angela J Rogers
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1332-7. 2007
    Loss-of-function mutations in the filaggrin gene (FLG) have been strongly associated with atopic dermatitis and allergic phenotypes in multiple populations...
  50. ncbi Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema
    Sara J Brown
    J Invest Dermatol 128:1591-4. 2008
  51. doi Filaggrin expression in oral, nasal, and esophageal mucosa
    Anna De Benedetto
    J Invest Dermatol 128:1594-7. 2008
  52. doi Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families
    Elisabeth Ekelund
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Acta Derm Venereol 88:15-9. 2008
    Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema...
  53. doi Unique and recurrent mutations in the filaggrin gene in Singaporean Chinese patients with ichthyosis vulgaris
    Huijia Chen
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    J Invest Dermatol 128:1669-75. 2008
    b>Filaggrin is an abundant protein of the outer epidermis that is essential for terminal differentiation of keratinocytes and formation of an effective barrier against water loss and pathogen/allergen/irritant invasion...
  54. doi Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum
    Sanja Kezic
    J Invest Dermatol 128:2117-9. 2008
  55. doi Filaggrin null mutations and childhood atopic eczema: a population-based case-control study
    Sara J Brown
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    J Allergy Clin Immunol 121:940-46.e3. 2008
    Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown.
  56. doi The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study
    John Henderson
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    J Allergy Clin Immunol 121:872-7.e9. 2008
    Atopic disease is a major health problem. Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma.
  57. doi Filaggrin mutations, atopic eczema, hay fever, and asthma in children
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 121:1203-1209.e1. 2008
    Mutations in the filaggrin gene (FLG) have been shown to play a significant role in ichthyosis vulgaris and eczema, 2 common chronic skin diseases...
  58. doi Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study
    Hisako Enomoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    J Hum Genet 53:615-21. 2008
    b>Filaggrin (FLG) plays an important role in the barrier function of the skin...
  59. pmc Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark
    PLoS Med 5:e131. 2008
    Loss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individuals may potentiate the effect of environmental exposures...
  60. doi Atopic eczema and the filaggrin story
    Sara J Brown
    Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Semin Cutan Med Surg 27:128-37. 2008
    The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema represents the single most significant breakthrough in understanding the genetic basis of this complex disorder...
  61. doi Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study
    C M de Jongh
    Coronel Institute of Occupational Health, Academic Medical Centre, University of Amsterdam, P O Box 22700, Amsterdam 1100 DE, The Netherlands
    Br J Dermatol 159:621-7. 2008
    Polymorphisms in the filaggrin (FLG) gene, which result in loss of filaggrin production, may alter the skin barrier and are a well-known predisposing factor for atopic dermatitis.
  62. doi The role of filaggrin loss-of-function mutations in atopic dermatitis
    Gráinne M O'Regan
    Department of Paediatric Dermatology, Our Lady s Children s Hospital, Crumlin, Dublin, Ireland
    Curr Opin Allergy Clin Immunol 8:406-10. 2008
    ..To provide a comprehensive summary of recent genetic advances as they relate to the pathogenesis of atopic dermatitis...
  63. doi An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma
    Ingo Marenholz
    Max Delbrück Centrum MDC for Molecular Medicine, Berlin, Germany
    J Allergy Clin Immunol 123:911-6. 2009
    Asthma prediction in early infancy is essential for the development of new preventive strategies. Loss-of-function mutations in the filaggrin gene (FLG) were identified as risk factors for eczema and associated asthma.
  64. doi Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease
    J Van Limbergen
    Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Inflamm Bowel Dis 15:1492-8. 2009
    Pediatric inflammatory bowel disease (IBD) has a high prevalence of coexistent atopy. Filaggrin (FLG) loss-of-function variants (null-alleles) are associated with eczema and asthma in association with eczema...
  65. doi Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease
    Elke Rodriguez
    Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Munich and ZAUM Center for Allergy and Environment, Technische Universitat Munchen, Munich, Germany
    J Allergy Clin Immunol 123:1361-70.e7. 2009
    The discovery of filaggrin (FLG) null mutations as a major risk factor for eczema represents a milestone toward the understanding of an important mechanism in this complex disease...
  66. pmc Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco, 94121, USA
    Curr Opin Allergy Clin Immunol 9:437-46. 2009
    ..We will review here emerging evidence that the inflammation in atopic dermatitis results from inherited and acquired insults to the barrier and the therapeutic implications of this new paradigm...
  67. pmc Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis
    Rosanne A H M van den Oord
    Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9DX
    BMJ 339:b2433. 2009
    To investigate whether filaggrin gene defects, present in up to one in 10 western Europeans and North Americans, increase the risk of developing allergic sensitisation and allergic disorders.
  68. doi Filaggrin null mutations in childhood atopic dermatitis among the Chinese
    G K Ching
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Int J Immunogenet 36:251-4. 2009
    Atopic dermatitis (AD) is associated with loss or reduced expression of filaggrin (FLG). We evaluated five FLG null mutations, namely R501X, 2282del4, R2447X, S2554X, and S2889X, in 174 Chinese children with AD and 191 matched controls...
  69. doi FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema
    I Nemoto-Hasebe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Br J Dermatol 161:1387-90. 2009
    Mutations in the gene encoding filaggrin (FLG) have been shown to predispose to atopic eczema (AE).
  70. pmc Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children
    S J Brown
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Dermatol 161:884-9. 2009
    Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological features of filaggrin haploinsufficiency have not been clearly defined.
  71. doi Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:R7-R12. 2009
    Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD.
  72. doi Novel and recurrent mutations in the filaggrin gene in Chinese patients with ichthyosis vulgaris
    X Zhang
    Laboratory of Genetics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
    Br J Dermatol 163:63-9. 2010
    Ichthyosis vulgaris (IV) is a common inherited skin disorder, and the filament aggregating protein (filaggrin) is a key protein involved in skin barrier function...
  73. doi The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population
    J P Thyssen
    National Allergy Research Centre, Department of Dermato Allergology, Copenhagen University Hospital Gentofte, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Br J Dermatol 162:1278-85. 2010
    It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization...
  74. doi Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model
    Michael Mildner
    Department of Dermatology, Medical University of Vienna, Vienna, Austria
    J Invest Dermatol 130:2286-94. 2010
    Loss-of-function mutations in the filaggrin gene are associated with ichthyosis vulgaris and atopic dermatitis...
  75. doi Filaggrin null mutations and association with contact allergy and allergic contact dermatitis: results from a tertiary dermatology clinic
    Berit Christina Carlsen
    National Allergy Research Centre, Department of Dermato Allergology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
    Contact Dermatitis 63:89-95. 2010
    b>Filaggrin null (FLG) mutations lead to skin barrier disruption with a reduced resistance towards exogenous agents and also influence the course of disease in atopic dermatitis.
  76. doi Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis
    H Zhang
    Department of Dermatology, Xinhua Hospital, Shanghai, China
    Allergy 66:420-7. 2011
    Recently, loss-of-function mutations in the filaggrin gene (FLG) have been identified as the cause of ichthyosis vulgaris (IV) and also predisposing factors for atopic dermatitis (AD) and AD-associated phenotypes...
  77. doi Latex allergy and filaggrin null mutations
    Berit C Carlsen
    National Allergy Research Centre, Department of Dermato Allergology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
    J Dent 39:128-32. 2011
    ..Health care workers share a high occupational risk for developing latex allergy. Filaggrin null mutations increase the risk of type I sensitizations to aeroallergens and it is possible that filaggrin ..
  78. ncbi Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age
    C Flohr
    Department of Children s Allergies, MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, UK
    Br J Dermatol 163:1333-6. 2010
    b>Filaggrin loss-of-function (FLG) mutations are associated with eczema and skin barrier impairment, but it is unclear whether skin barrier impairment precedes phenotypic eczema in FLG mutation carriers.
  79. doi Nickel reactivity and filaggrin null mutations--evaluation of the filaggrin bypass theory in a general population
    Katrine Ross-Hansen
    Department of Dermato Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
    Contact Dermatitis 64:24-31. 2011
    It was recently shown that filaggrin null mutation carrier status was associated with nickel allergy and self-reported intolerance to costume jewellery...
  80. doi Filaggrin polymorphism P478S, IgE level, and atopic phenotypes
    I J Wang
    Department of Pediatrics, Taipei Hospital, Department of Health, Taipei, Taiwan
    Br J Dermatol 164:791-6. 2011
    ..Whether environmental exposures may modulate the effect of the skin barrier gene on atopic dermatitis (AD) remains to be elucidated...
  81. doi Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling
    Irena Angelova-Fischer
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Exp Dermatol 20:351-6. 2011
    b>Filaggrin gene (FLG) loss-of-function mutations have been shown to represent the strongest so far known genetic risk factor for atopic dermatitis (AD)...
  82. doi Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis
    Aleksandra Lesiak
    Department of Dermatology, Medical University of Lodz, Lodz, Poland
    Exp Dermatol 20:491-5. 2011
    Although filaggrin mutations are presently believed to play a key role in the development of atopic dermatitis (AD), obviously also immunological factors involved in acquired immune response are important for the development of allergic ..
  83. doi Association between filaggrin null mutations and concomitant atopic dermatitis and contact allergy
    B C Carlsen
    National Allergy Research Centre, Department of Dermato Allergology, Copenhagen University Hospital Gentofte, Hellerup, Denmark
    Clin Exp Dermatol 36:467-72. 2011
    The phenotypic traits of people with the filaggrin mutation (FLG) genotype and atopic dermatitis (AD) are still under elucidation, and the association with concomitant AD and contact allergy (CA) has not previously been examined.
  84. pmc Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function
    Robert Gruber
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Am J Pathol 178:2252-63. 2011
    Although it is widely accepted that filaggrin (FLG) deficiency contributes to an abnormal barrier function in ichthyosis vulgaris and atopic dermatitis, the pathomechanism of how FLG deficiency provokes a barrier abnormality in humans is ..
  85. doi Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population
    Liang Dan Sun
    Institute of Dermatology and Department of Dermatology, No 1 Hospital, Anhui Medical University, Hefei, Anhui, China
    Nat Genet 43:690-4. 2011
    ..0 × 10(-8), OR = 1.17) and replicated another previously reported locus at 1q21.3 (FLG, rs3126085, P(combined) = 5.90 × 10(-12), OR = 0.82) in the Chinese sample. The 20q13...
  86. doi Filaggrin loss-of-function mutation R501X and 2282del4 carrier status is associated with fissured skin on the hands: results from a cross-sectional population study
    J P Thyssen
    National Allergy Research Centre, Department of Dermato Allergology, Copenhagen University Hospital Gentofte, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Br J Dermatol 166:46-53. 2012
    b>Filaggrin metabolites act as osmolytes and are important for skin hydration. Carriers of filaggrin loss-of-function mutations have a higher prevalence of atopic dermatitis and dry skin...
  87. doi Interaction between filaggrin null mutations and tobacco smoking in relation to asthma
    Nikolaj Drimer Berg
    Research Centre for Prevention and Health, Glostrup University Hospital, The Capital Region of Denmark, Glostrup, Denmark
    J Allergy Clin Immunol 129:374-80, 380.e1-2. 2012
    The mechanisms underlying the association between filaggrin (FLG) deficiency and asthma are not known...
  88. doi Mutations analysis in filaggrin gene in northern China patients with atopic dermatitis
    M Li
    Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Eur Acad Dermatol Venereol 27:169-74. 2013
    Recently, we have reported filaggrin mutations (FLG) of atopic dermatitis in southern China. However, there have been few detailed reports of FLG mutations of patients with AD in northern China by now.
  89. doi IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion
    Danuta Gutowska-Owsiak
    MRC Human Immunology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Exp Dermatol 21:104-10. 2012
    ..Recent findings indicated that filaggrin is essential during barrier formation and its insufficiency underlies the pathogenesis of atopic eczema...
  90. doi Clinical course of occupational irritant contact dermatitis of the hands in relation to filaggrin genotype status and atopy
    L Landeck
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Br J Dermatol 167:1302-9. 2012
    b>Filaggrin loss-of-function mutations and atopy may alter the clinical course of irritant contact dermatitis (ICD).
  91. pmc Common FLG mutation K4671X not associated with atopic dermatitis in Han Chinese in a family association study
    Ruhong Cheng
    Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS ONE 7:e49158. 2012
    b>Filaggrin gene (FLG) mutations have been identified as the cause of ichthyosis vulgaris (IV) and major predisposing factors for atopic dermatitis (AD). The relationship among AD, IV and FLG mutations has not been clarified yet...
  92. pmc Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study
    Charlotte Giwercman Carson
    Copenhagen Prospective Studies on Asthma in Childhood COPSAC, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    PLoS ONE 7:e48678. 2012
    b>Filaggrin null mutations result in impaired skin barrier functions, increase the risk of early onset atopic dermatitis and lead to a more severe and chronic disease...
  93. pmc Vitamin D status, filaggrin genotype, and cardiovascular risk factors: a Mendelian randomization approach
    Tea Skaaby
    Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark
    PLoS ONE 8:e57647. 2013
    ..Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of ..
  94. doi Association between loss-of-function mutations in the filaggrin gene and self-reported food allergy and alcohol sensitivity
    Allan Linneberg
    Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark alllin01 regionh dk
    Int Arch Allergy Immunol 161:234-42. 2013
    Loss-of-function mutations of the filaggrin (FLG) gene cause an impaired skin barrier and increase the risk of atopic dermatitis. Interestingly, FLG mutations have also been found to be associated with a high risk of peanut allergy.
  95. ncbi Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis
    Aileen Sandilands
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    J Invest Dermatol 126:1770-5. 2006
    Mutations in the filament aggregating protein (filaggrin) gene have recently been identified as the cause of the common genetic skin disorder ichthyosis vulgaris (IV), the most prevalent inherited disorder of keratinization...
  96. ncbi Filaggrin mutations in children with severe atopic dermatitis
    Nilesh Morar
    National Heart and Lung Institute, Molecular Genetics Division, Imperial College, London, UK
    J Invest Dermatol 127:1667-72. 2007
    ..b>Filaggrin (FLG) is one of these...
  97. ncbi Rat epidermal cathepsin L-like proteinase: purification and some hydrolytic properties toward filaggrin and synthetic substrates
    A Kawada
    Department of Dermatology, National Defense Medical College, Saitama
    J Biochem 118:332-7. 1995
    ..The enzyme effectively proteolyzed rat epidermal filaggrin into small fragments at pH 4.0-6...
  98. ncbi [Clinical features of the nephrotic syndrome associated with ichthyosis vulgaris and analysis of related gene mutation]
    Zhi hui Li
    Department of Nephrology, Kidney Laboratory of Hunan Pediatric Research Institute, Hunan Children s Hospital, Changsha 410007, China
    Zhonghua Er Ke Za Zhi 48:44-9. 2010
    To study clinical features of 3 children who presented with nephrotic syndrome (NS) associated with ichthyosis vulgaris (IV), and to detect relationship between NS associated with IV in patients and FLG gene or NPHS2 gene.
  99. ncbi Identification of a genetic locus for ichthyosis vulgaris on chromosome 10q22.3-q24.2
    Ping Liu
    Key Laboratory of Molecular Biophysics of Ministry of Education, Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    J Invest Dermatol 128:1418-22. 2008
    ..29% in China. To date, only one gene responsible for IV, the filaggrin gene (FLG), was identified, but genetic heterogeneity exists...
  100. pmc Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens
    Tiffany C Scharschmidt
    Department of Dermatology, Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 124:496-506, 506.e1-6. 2009
    Mutations in the human filaggrin gene (FLG) are associated with atopic dermatitis (AD) and are presumed to provoke a barrier abnormality...

Research Grants11

  1. DENNIS ROOP; Fiscal Year: 2015
    ..complex (EDC), a conserved cluster of epidermal differentiation genes including loricrin (LOR) and filaggrin (FLG), both of which play important roles in the formation and maintenance of epidermal barrier function...
  2. Nature of mamalian Cutaneous Permeablilty Barrier
    Peter M Elias; Fiscal Year: 2012
    ..recent linkage studies show that inherited mutations in a stratum corneum (SC) structural protein, filaggrin (FLG) occur in up to 30 percent of AD patients of European origin...
  3. Filaggrin Mutations and the Prognosis of Atopic Dermatitis
    David J Margolis; Fiscal Year: 2013
    ..This defect was due to a loss- of-function mutation for the production of a protein called filaggrin (FLG). The gene is located on chromosome 1q21...
  4. Mark H Kaplan; Fiscal Year: 2016
    ..component in disease;family history of allergy is one of the strongest predictors of AD, and mutations in the filaggrin (FLG) gene, a component of the Epidermal Differentiation Complex (EDC), have emerged as a predisposing factor ..
  5. ENDOTHELIAL CELLS AND OSTEOCLAST DEVELOPMENT
    Patricia Collin Osdoby; Fiscal Year: 1999
    ..will be analyzed in chick marrow mononuclear cell cultures and a human preosteoclastic cell line (FLG 29.1), both capable of forming osteoclast-like giant cells in vitro...
  6. GENES CONTROLLING PIGMENTATION
    Ruth Halaban; Fiscal Year: 1999
    ..goal will be accomplished by transfecting melanoma cells, with eukaryotic expression vectors encoding a) anti-sense bFGF mRNA; b) a kinase-truncated, dominant negatively acting bFGF receptor (FGFR1/FLG); and c) an inducible mi minigene.
  7. FLAGELLAR REGULATION AND SALMONELLA VIRULENCE
    ALISON O BRIEN; Fiscal Year: 2000
    ..typhimurium that differ only at the mviS locus and to compare the virulence of the flg+mviS+ and flg+mviS- strains for C57BL/6J mice and the survival of each member of the isogenic pair: i) in ..
  8. CELL SURFACE AND OSTEOCLAST DEVELOPMENT
    Philip Osdoby; Fiscal Year: 2000
    ..Highly purified chick osteoclasts and a human leukemic cell line (FLG 29.1) will be used as sources for chicken and human antigens...
  9. Genetic Studies of Immune Responsiveness to Cockroach
    Kathleen Barnes; Fiscal Year: 2007
    ..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..
  10. AIRWAY DISEASE AND COCKROACH EXPOSURE IN PUBLIC HOUSING
    Kathleen Barnes; Fiscal Year: 2008
    ..We hope that with the data to be generated, we will positively impact the health of urban US populations who are disproportionally suffering from asthma morbidity and mortality. ..
  11. Genome-Wide Association Studies of Asthma in Populations of African Descent
    Kathleen Barnes; Fiscal Year: 2008
    ..Findings from this study will provide a better understanding of the complex pathways related to risk of asthma and associated phenotypes. [unreadable] [unreadable] [unreadable]..