FKBP51

Summary

Gene Symbol: FKBP51
Description: FK506 binding protein 5
Alias: AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, peptidyl-prolyl cis-trans isomerase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, 54 kDa progesterone receptor-associated immunophilin, FF1 antigen, FKBP-51, HSP90-binding immunophilin, PPIase FKBP5, T-cell FK506-binding protein, androgen-regulated protein 6, peptidylprolyl cis-trans isomerase, rotamase
Species: human

Top Publications

  1. ncbi The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness
    Tina R Hubler
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    Endocrinology 144:2380-7. 2003
  2. ncbi Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
  3. doi Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 28:389-98. 2008
  4. ncbi Two FKBP-related proteins are associated with progesterone receptor complexes
    D F Smith
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198
    J Biol Chem 268:18365-71. 1993
  5. ncbi Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90
    J C Young
    Department of Cellular Biochemistry, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 273:18007-10. 1998
  6. ncbi A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins
    Todd H Davies
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 277:4597-600. 2002
  7. ncbi Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors
    Stephane Giraudier
    INSERM U362, Pavillon de Recherche 1, Institut Gustave Roussy, Villejuif Cedex, France Laboratoire d Hématologie and Laboratoire de Toxicologie, Hopital Henri Mondor, Creteil, France
    Blood 100:2932-40. 2002
  8. pmc Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
    Cindy R Sinars
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
    Proc Natl Acad Sci U S A 100:868-73. 2003
  9. ncbi FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Biol Chem 280:4609-16. 2005
  10. ncbi Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children
    K C Koenen
    Mol Psychiatry 10:1058-9. 2005

Research Grants

  1. IMMUNOPHILIN INTERACTIONS WITH STEROID RECEPTORS
    David Smith; Fiscal Year: 2006
  2. Role of calcineurin in store-operated calcium entry of pulmonary endothelium
    AUDREY ANNE VASAUSKAS; Fiscal Year: 2013
  3. Chad A Dickey; Fiscal Year: 2016
  4. THE ROLE OF PIN1 IN MITOSIS WITH DESIGNED INHIBITORS
    FELICIA ETZKORN; Fiscal Year: 2002
  5. Pharmacogenomics and Mechanisms of Cytidine Analogues
    Liewei Wang; Fiscal Year: 2013
  6. Donna L Cioffi; Fiscal Year: 2016
  7. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
  8. Social, Genetic Determinants of Blood Pressure in Underserved African Americans
    SANDRA MARIE COULON; Fiscal Year: 2013
  9. Joel D Richter; Fiscal Year: 2015
  10. Yeast Ess1, a Conserved PPlase Essential for Mitosis
    Steven D Hanes; Fiscal Year: 2010

Detail Information

Publications282 found, 100 shown here

  1. ncbi The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness
    Tina R Hubler
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    Endocrinology 144:2380-7. 2003
    b>FKBP51 and FKBP52 are large molecular weight FK506-binding immunophilins that have diverse biochemical functions. Best studied is the role that they play as components of steroid hormone receptors...
  2. ncbi Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
  3. doi Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 28:389-98. 2008
    ..This reaction pattern suggests that subjects carrying these variants are at risk of displaying chronically elevated cortisol levels after repeated stress constituting a risk factor for stress-related diseases...
  4. ncbi Two FKBP-related proteins are associated with progesterone receptor complexes
    D F Smith
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198
    J Biol Chem 268:18365-71. 1993
    ..the present study, we obtained partial amino acid sequences for two avian progesterone receptor components, p50 and p54. From sequence comparisons with known proteins, they appear to be distinct members of the FKBP family of ..
  5. ncbi Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90
    J C Young
    Department of Cellular Biochemistry, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 273:18007-10. 1998
    ..C90) was found to mediate the interaction of hsp90 with TPR-containing sequences from the hsp90 cofactors FKBP51/54 and FKBP52...
  6. ncbi A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins
    Todd H Davies
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 277:4597-600. 2002
    ..dissociation of the cytoplasmic GR heterocomplex, binding of hormone-induced substitution of one immunophilin (FKBP51) for another (FKBP52), and concomitant recruitment of the transport protein dynein while leaving Hsp90 unchanged...
  7. ncbi Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors
    Stephane Giraudier
    INSERM U362, Pavillon de Recherche 1, Institut Gustave Roussy, Villejuif Cedex, France Laboratoire d Hématologie and Laboratoire de Toxicologie, Hopital Henri Mondor, Creteil, France
    Blood 100:2932-40. 2002
    ..Using a differential display technique, we found that the immunophilin FKBP51 was 2 to 8 times overexpressed in megakaryocytes derived from patients' CD34(+) cells in comparison to normal ..
  8. pmc Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
    Cindy R Sinars
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
    Proc Natl Acad Sci U S A 100:868-73. 2003
    ..b>FKBP51 (the 51-kDa FKBP) associates with heat shock protein 90 (Hsp90) and appears in functionally mature steroid ..
  9. ncbi FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Biol Chem 280:4609-16. 2005
    ..Increasing the levels of FKBP51 reduced the transcriptional activity of the receptor, as reported...
  10. ncbi Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children
    K C Koenen
    Mol Psychiatry 10:1058-9. 2005
  11. ncbi Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element
    Jeffrey A Magee
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 147:590-8. 2006
    ..Rather, the distal enhancer complex and basal transcription apparatus communicate indirectly with one another, implicating a regulatory mechanism that has not been previously appreciated for AR target genes...
  12. pmc The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort
    Magnus Lekman
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 63:1103-10. 2008
    ..The present study aimed at studying the associated FKBP5 markers in the ethnically diverse Sequenced Treatment Alternatives to Relieve Depression (STAR*D) sample of non-hospitalized patients treated with citalopram...
  13. pmc FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway
    Wei Jiang
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Neoplasia 10:235-43. 2008
    ..In conclusion, our study demonstrates that FKBP5 plays an important role in glioma growth and chemoresistance through regulating signal transduction of the NF-kappaB pathway...
  14. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...
  15. doi Genetic variants in FKBP5 affecting response to antidepressant drug treatment
    Julia Kirchheiner
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Helmholtzstr 20, 89081 Ulm, Germany
    Pharmacogenomics 9:841-6. 2008
    ..We aimed to analyze whether these findings could be reproduced in a different sample of otherwise comparable inpatients with major depression...
  16. pmc Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder
    Erick T Tatro
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Brain Res 1286:1-12. 2009
    ..FKBP52, inhibited cortisol-activated GR nuclear translocation, while knockdown of FKBP5, coding for immunophilin FKBP51, was associated with increased baseline GR nuclear localization...
  17. doi The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 34:S186-95. 2009
    ..In addition, they are also associated with faster response to antidepressant treatment. FKBP5 might thus be an interesting therapeutic target for the prevention and treatment of stress-related psychiatric disorders...
  18. pmc FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
    Huadong Pei
    Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Cell 16:259-66. 2009
    ..However, how PHLPP is targeted to Akt is not clear. Here we show that FKBP51 (FK506-binding protein 51) acts as a scaffolding protein for Akt and PHLPP and promotes dephosphorylation of Akt...
  19. pmc FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A
    S Periyasamy
    Center for Diabetes and Endocrine Research CeDER, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614 2598, USA
    Oncogene 29:1691-701. 2010
    ..Tetratricopeptide repeat (TPR) proteins (FKBP52, FKBP51 and Cyp40) interact with AR in PCa cells, suggesting roles in AR-mediated gene transcription and cell growth...
  20. pmc FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells
    Li Ni
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 30:1243-53. 2010
    ..Here, we report that the Hsp90 cochaperone FKBP51 is upregulated in LAPC-4 AI tumors grown in castrated mice and describe a molecular mechanism by which FKBP51 ..
  21. pmc Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide
    Alec Roy
    Psychiatry Service, Department of Veterans Affairs, New Jersey VA Health Care System, East Orange, NJ 07018, USA
    Neuropsychopharmacology 35:1674-83. 2010
    ..These data suggest that childhood trauma and variants of the FKBP5 gene may interact to increase the risk for attempting suicide...
  22. pmc Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 35:1684-92. 2010
    ..This study provides further evidence of a gene x environment effect of FKBP5 and childhood abuse on the risk for PTSD in AAs. Further study is required in other populations...
  23. doi FKBP5 and resistant attachment predict cortisol reactivity in infants: gene-environment interaction
    Maartje P C M Luijk
    Centre for Child and Family Studies, Leiden University, The Netherlands
    Psychoneuroendocrinology 35:1454-61. 2010
    ..Findings are discussed from the perspective of gene-environment interaction...
  24. pmc Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks
    Casey Sarapas
    Department of Psychology, University of Illinois at Chicago, USA
    Dis Markers 30:101-10. 2011
    ..An analysis of indirect effects revealed that homozygosity for any of 4 PTSD risk-related polymorphisms at FKBP5 predicted FKBP5 expression, which mediated indirect effects of genotype on plasma cortisol and PTSD severity...
  25. pmc Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies
    Divya Mehta
    Max Planck Institute of Psychiatry, Kraepelinstrasse, Munich, Germany
    Arch Gen Psychiatry 68:901-10. 2011
    ..Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an increased risk to develop posttraumatic stress disorder (PTSD)...
  26. doi Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90
    Andreas Bracher
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Acta Crystallogr D Biol Crystallogr 67:549-59. 2011
    ..FK506-binding protein 51 (FKBP51) has been shown to reduce glucocorticoid receptor signalling and has been genetically associated with human stress ..
  27. pmc Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population
    Katja Appel
    Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    Neuropsychopharmacology 36:1982-91. 2011
    ..Given the large effect sizes, rs1360780 could be included into prediction models for depression in individuals exposed to childhood abuse...
  28. pmc The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress
    Luciana I Gallo
    Instituto de Biología y Medicina Experimental Consejo Nacional de Investigaciones Científicas y Técnicas IBYME CONICET, Buenos Aires, Argentina
    J Biol Chem 286:30152-60. 2011
    Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker MitoTracker...
  29. pmc Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study
    Petra Zimmermann
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Psychiatry 168:1107-16. 2011
    ..The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode...
  30. doi FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior
    Chadi Touma
    Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 70:928-36. 2011
    ..However, translational studies including genetic animal models are lacking...
  31. doi Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
    Natalia M Galigniana
    Instituto de Biologia y Medicina Experimental IByME CONICET, Buenos Aires, Argentina
    J Neurochem 122:4-18. 2012
    ..Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of ..
  32. pmc Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions
    Torsten Klengel
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Neurosci 16:33-41. 2013
    ..This identification of molecular mechanisms of genotype-directed long-term environmental reactivity will be useful for designing more effective treatment strategies for stress-related disorders...
  33. pmc Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults
    Pamela Belmonte Mahon
    The Johns Hopkins Mood Disorders Center, Baltimore, MD, USA
    Psychopharmacology (Berl) 227:231-41. 2013
    ..Variations in the genes encoding these proteins, FKBP5 and CRHR1, have been associated with several neuropsychiatric disorders...
  34. doi Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression
    A Menke
    Department of Molecular Genetics of Affective Disorders, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Genes Brain Behav 12:289-96. 2013
    ..This finding suggests that endocrine alterations in depressed patients are determined by genetic variants and may allow identification of specific subgroups...
  35. pmc FKBP5 and attention bias for threat: associations with hippocampal function and shape
    Negar Fani
    Departments of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA Psychiatry 70:392-400. 2013
    ..The study of intermediate phenotypes, such as emotion-processing biases and their neural substrates, provides a way to clarify the mechanisms by which FKBP5 dysregulation mediates risk for psychiatric disorders...
  36. doi FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
    Dina Collip
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Br J Psychiatry 202:261-8. 2013
    ..FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma...
  37. doi Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders
    Alessandra Minelli
    Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
    Depress Anxiety 30:1170-6. 2013
    ....
  38. doi Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood
    Arlette F Buchmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159 Mannheim, Germany
    Eur Neuropsychopharmacol 24:837-45. 2014
    ....
  39. ncbi Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition
    G Baughman
    Regulatory Biology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186 5800, USA
    Biochem Biophys Res Commun 232:437-43. 1997
    We previously described the isolation of an FK506-binding protein, FKBP51, that is predominantly expressed in murine T cells and is capable of mediating drug-dependent calcineurin inhibition in vitro...
  40. pmc Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    Erick T Tatro
    Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
    J Neuroimmune Pharmacol 4:218-26. 2009
    ..Immunophilins FKBP51 and FKBP52 are expressed in cortical neurons and regulate the function of the glucocorticoid receptor (GR)...
  41. doi Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells
    S Romano
    Department of Biochemistry and Medical Biotechnology, Federico II University of Naples, Naples, Italy
    Cell Death Differ 17:145-57. 2010
    FK506-binding protein 51 (FKBP51) is an immunophilin with isomerase activity, which performs important biological functions in the cell. It has recently been involved in the apoptosis resistance of malignant melanoma...
  42. ncbi Expression of long- and short-type FK506 binding proteins in hyperthermophilic archaea
    Akira Ideno
    Marine Biotechnology Institute, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 292:57-63. 2002
    ..clarify the difference between their roles in archaeal cells, they were expressed in Escherichia coli, and their PPIase and chaperone-like protein-folding activities were investigated...
  43. ncbi Archaeal peptidyl prolyl cis-trans isomerases (PPIases) update 2004
    Tadashi Maruyama
    Japan Marine Science and Technology Center, 2 15 Natsushima cho, Yokosuka shi, Kanagawa 237 0061, Japan
    Front Biosci 9:1680-720. 2004
    ..This is a cyclosporin A (CsA) sensitive CyP with a molecular weight of 19.4 kDa. The PPIase activity and CsA sensitivity of HbsCyP19 is higher at higher salt concentration in the medium...
  44. ncbi Archaeal peptidyl prolyl cis-trans isomerases (PPIases)
    T Maruyama
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi shi, Iwate 026 0001, Japan
    Front Biosci 5:D821-36. 2000
    ..It is a cyclosporin A (CsA) sensitive CyP with a MW of 19.4kDa. The PPIase activity and CsA sensitivity of this CyP is higher at higher salt concentration in the medium...
  45. doi Identification of functional FKB protein in Echinococcus granulosus: its involvement in the protoscolicidal action of rapamycin derivates and in calcium homeostasis
    Andrea C Cumino
    Laboratorio de Zoonosis Parasitarias, Departamento de Biologia, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata UNMdP, Funes 3350, Nivel Cero, 7600 Mar del Plata, Argentina
    Int J Parasitol 40:651-61. 2010
    ..These proteins display a peptidyl-prolyl rotamase function that is believed to catalyze protein folding and they are well-validated anti-proliferative drug targets ..
  46. ncbi Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex
    G Wiederrecht
    Department of Immunology Research, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 267:21753-60. 1992
    ..has been purified to homogeneity, migrates with an apparent mass of 51 kDa on denaturing gels, and has been termed FKBP51. Like FKBP12, FKBP51 has PPIase activity, but, unlike FKBP12.FK-506, FKBP51...
  47. pmc A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus
    B M Benton
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202
    J Cell Biol 127:623-39. 1994
    The gene (FPR3) encoding a novel type of peptidylpropyl-cis-trans-isomerase (PPIase) was isolated during a search for previously unidentified nuclear proteins in Saccharomyces cerevisiae...
  48. pmc FK506 binding protein from the hyperthermophilic archaeon Pyrococcus horikoshii suppresses the aggregation of proteins in Escherichia coli
    Akira Ideno
    Marine Biotechnology Institute Co, Ltd, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, Iwate 026 000, Japan
    Appl Environ Microbiol 68:464-9. 2002
    The 29-kDa FK506 binding protein (FKBP) gene is the only peptidyl-prolyl cis-trans isomerase (PPIase) gene in the genome of Pyrococcus horikoshii...
  49. pmc Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin
    N Maki
    Corporate Research and Development Laboratory, Saitama, Japan
    Proc Natl Acad Sci U S A 87:5440-3. 1990
    ..This is in contrast to the result that as many as 20 copies of the cyclophilin gene and possible pseudogenes may be present in the mammalian genome...
  50. ncbi FKBP-type peptidyl-prolyl cis-trans isomerase from a sulfur-dependent hyperthermophilic archaeon, Thermococcus sp. KS-1
    T Iida
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 222:249-55. 1998
    A gene encoding an FK506 binding protein (FKBP)-type peptidyl-prolyl cis-trans isomerase (PPIase) was cloned from a hyperthermophilic archaeon, Thermococcus sp. KS-1, and sequenced...
  51. ncbi FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitro
    M Furutani
    Kamaishi Laboratories, Marine Biotechnology Institute Co Ltd, 3 75 1 Heita Kamaishi, Iwate 026 0001, Japan
    Biochemistry 39:453-62. 2000
    ..MTFK exhibited FK506 sensitive PPIase (peptidyl prolyl cis-trans isomerase) activity which accelerated the speed of ribonuclease T1 refolding, which is ..
  52. ncbi FK506-binding protein-type peptidyl-prolyl cis-trans isomerase from a halophilic archaeum, Halobacterium cutirubrum
    T Iida
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, 026 0001, Iwate, Japan
    Gene 256:319-26. 2000
    ..archaeum, Halobacterium cutirubrum, has been shown to have a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase)...
  53. ncbi A novel role for the immunophilin FKBP52 in copper transport
    Reiko Sanokawa-Akakura
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Biol Chem 279:27845-8. 2004
    FK506-binding protein 52 (FKBP52) is an immunophilin that possesses peptidylprolyl cis/trans-isomerase (PPIase) activity and is a component of a subclass of steroid hormone receptor complexes...
  54. doi FKBP family proteins: immunophilins with versatile biological functions
    Cong Bao Kang
    School of Biological Science, Nanyang Technological University, Singapore, Singapore
    Neurosignals 16:318-25. 2008
    ..of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity...
  55. ncbi The 28.3 kDa FK506 binding protein from a thermophilic archaeum, Methanobacterium thermoautotrophicum, protects the denaturation of proteins in vitro
    A Ideno
    Marine Biotechnology Institute Co, Ltd, Kamaishi, Iwate, Japan Sekisui Chemical Co, Ltd, Minase Research Institute, Osaka, Japan
    Eur J Biochem 267:3139-49. 2000
    Two families of FK506 binding protein (FKBP) type peptidyl-prolyl cis-trans isomerase (PPIase) have been found in Archaea. One is the 16-18 kDa short type FKBP family, and another is the 26-30 kDa long type FKBP family...
  56. pmc FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae
    J Heitman
    Department of Biochemistry, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 88:1948-52. 1991
    ..In vitro, FK 506 binds and inhibits the activity of FK 506-binding protein (FKBP), a peptidylprolyl rotamase (cis-trans isomerase). Cyclosporin A acts similarly on a different proline rotamase, cyclophilin...
  57. doi SUMO-conjugating enzyme (Sce) and FK506-binding protein (FKBP) encoding rice (Oryza sativa L.) genes: genome-wide analysis, expression studies and evidence for their involvement in abiotic stress response
    Neha Nigam
    Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India
    Mol Genet Genomics 279:371-83. 2008
    ..of two major stress proteins namely SUMO-conjugating enzyme (Sce) and peptidyl prolyl cis-trans isomerase (PPIase) in rice (Oryza sativa L.)...
  58. ncbi Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes
    R L Barent
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Mol Endocrinol 12:342-54. 1998
    b>FKBP51, FKBP52, and Cyp40 bind competitively to Hsp90 through their respective tetratricopeptide repeat (TPR) domains, and any one of the three immunophilins can be isolated in mature steroid receptor complexes...
  59. ncbi NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein
    Martin Vogtherr
    Institut für Organische Chemie der Universität Frankfurt, Marie Curie Str 11, 60439 Frankfurt, Germany
    J Mol Biol 318:1097-115. 2002
    We have solved the solution structure of the peptidyl-prolyl cis-trans isomerase (PPIase) domain of the trigger factor from Mycoplasma genitalium by homo- and heteronuclear NMR spectroscopy...
  60. ncbi The Escherichia coli FKBP-type PPIase SlyD is required for the stabilization of the E lysis protein of bacteriophage phi X174
    Thomas G Bernhardt
    Department of Biochemistry and Biophysics, Texas A and M University, 77843 2128, USA
    Mol Microbiol 45:99-108. 2002
    ..The slyD gene encodes a FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)...
  61. doi Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate
    Cahyo Budiman
    Department of Material and Life Science, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan
    FEBS J 276:4091-101. 2009
    ..SIB1 is a homodimeric protein with peptidyl prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) activity. Each monomer consists of 205 amino acid residues...
  62. doi Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus
    Christian Löw
    Institut fur Physik, Biophysik, Martin Luther Universitat Halle Wittenberg, D 06099 Halle Saale, Germany
    J Mol Biol 398:375-90. 2010
    SlyD (sensitive to lysis D; product of the slyD gene) is a prolyl isomerase [peptidyl-prolyl cis/trans isomerase (PPIase)] of the FK506 binding protein (FKBP) type with chaperone properties...
  63. ncbi Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)
    M C Coss
    Laboratory of Experimental Immunology, NCI Frederick Cancer Research and Development Center, National Institute of Health, Maryland 21702 1201, USA
    J Biol Chem 270:29336-41. 1995
    ..FKBP65 contains four predicted peptidylprolyl cistrans-isomerase (PPIase) signature domains, and, although similar in size, is distinct from FKBP52 (also identified as FKBP59, hsp56, or ..
  64. ncbi Structural and functional studies of FkpA from Escherichia coli, a cis/trans peptidyl-prolyl isomerase with chaperone activity
    F A Saul
    Unité d Immunologie Structurale C N R S U R A 2185, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Mol Biol 335:595-608. 2004
    The protein FkpA from the periplasm of Escherichia coli exhibits both cis/trans peptidyl-prolyl isomerase (PPIase) and chaperone activities...
  65. pmc Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2
    J B Nielsen
    Merck Research Laboratories, Rahway, NJ 07065
    Proc Natl Acad Sci U S A 89:7471-5. 1992
    ..Furthermore, fkb2 null mutations confer no change in rapamycin sensitivity. These findings show that yFKBP-13 and yFKBP-12 have distinct functions within the cell...
  66. doi Association study between a functional polymorphism of FK506-binding protein 51 (FKBP5) gene and personality traits in healthy subjects
    Naoshi Shibuya
    Department of Psychiatry, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Neurosci Lett 485:194-7. 2010
    ..FK506-binding protein 51 (FKBP51 or FKBP5) is a co-chaperone of heat-shock protein 90, and plays an important role in the negative feedback ..
  67. pmc FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness
    Xinyu Zhang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 49:1037-47. 2008
    ..Over-expression of the FK506-binding immunophilin FKBP51 also causes a generalized state of glucocorticoid resistance...
  68. doi Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions
    Ville Paakinaho
    Institute of Biomedicine Medical Biochemistry, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
    Mol Endocrinol 24:511-25. 2010
    Recent studies have identified FKBP51 (FK506-binding protein 51) as a sensitive biomarker of corticosteroid responsiveness in vivo...
  69. pmc Requirements for peptidyl-prolyl isomerization activity: a comprehensive mutational analysis of the substrate-binding cavity of FK506-binding protein 12
    Teikichi Ikura
    Laboratory of Structural Biology, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Protein Sci 16:2618-25. 2007
    Peptidyl-prolyl isomerase (PPIase) activity is exhibited by many proteins belonging to the PPIase family. However, the catalytic mechanism of this activity remains to be completely elucidated...
  70. doi Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain
    Tamar Unger
    Department of Structural Biology, Weizmann Institute of Science, 76100, Rehovot, Israel
    J Struct Funct Genomics 11:113-23. 2010
    ..The wFK73_1 domain is responsible for binding FK506 and for peptidyl prolyl cis/trans isomerase (PPIase) activity, while the wFK73_2 and wFK73_3 domains lack these activities...
  71. ncbi Peptide binding induces large scale changes in inter-domain mobility in human Pin1
    Doris M Jacobs
    Institut für Organische Chemie und Chemische Biologie, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt, Germany
    J Biol Chem 278:26174-82. 2003
    Pin1 is a peptidyl-prolyl cis/trans isomerase (PPIase) essential for cell cycle regulation...
  72. ncbi Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides rapamycin and FK506 inhibit progestin- and glucocorticosteroid receptor-mediated transcription in human breast cancer T47D cells
    S Le Bihan
    URA 1218 Centre Nationale de la Recherche Scientifique, Chatenay Malabry, France
    Mol Endocrinol 12:986-1001. 1998
    ..to the heat shock proteins of 90 kDa and 70 kDa (hsp90 and hsp70), the FK506-binding immunophilin FKBP52 but not FKBP51, although the latter was part of unliganded PR heterocomplex associated with hsp90...
  73. ncbi Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506
    Todd H Davies
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Biochemistry 44:2030-8. 2005
    ..In this work, we have investigated the effects of four TPR proteins (FKBP52, FKBP51, Cyp40, and PP5) on hormone-binding function of glucocorticoid receptor (GR) endogenously expressed in mammalian ..
  74. pmc Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders
    John H Fingert
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA
    Mol Vis 16:596-601. 2010
    ....
  75. ncbi [Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]
    De Li Zhang
    Peking University Center for Human Disease Genomics, China National Center for Human Genome Research, Beijing 100083, China
    Yi Chuan Xue Bao 29:377-83. 2002
    ..respectively, are drosophila serine-arginine-rich protein 54 (SRp54) and human arginine-rich nuclear protein 54 (p54)...
  76. doi Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy
    Peixin Yang
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 198:130.e1-7. 2008
    ..To establish a link between oxidative stress signaling and diabetic embryopathy, levels of phosphorylated-p66Shc (which is a key signaling molecule that mediates oxidative stress-induced apoptosis) were evaluated...
  77. pmc Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock
    P J Mark
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands WA, Australia
    Cell Stress Chaperones 6:59-70. 2001
    ..Together with its partner cochaperones, cyclophilin 40 (CyP40) and FKBP51, FKBP52 belongs to a distinct group of structurally related immunophilins that modulate steroid receptor function ..
  78. ncbi Peptidyl prolyl cis/trans-isomerases: comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates
    Ralph Golbik
    Institute of Biochemistry, Department of Enzymology, Martin Luther University Halle Wittenberg, Kurt Mothes Strasse 3, 06120 Halle Saale, Germany
    Biochemistry 44:16026-34. 2005
    ..The proline residue in PPIase substrates at the P1' subsite, which follows the isomerizing peptide bond, appears to be the common recognition ..
  79. ncbi Cloning and characterization of ppiB, a Bacillus subtilis gene which encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase
    M Herrler
    Philipps Universitat Marburg, Fachbereich Chemie Biochemie, Germany
    Mol Microbiol 11:1073-83. 1994
    ..and internal peptide fragments of the purified 17 kDa Bacillus subtilis peptidyl-prolyl cis-trans isomerase (PPIase) revealed sequence identity to conserved regions of a number of eukaryotic and prokaryotic cyclophilins...
  80. pmc Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases
    Angelika Kühlewein
    Department Chemie, OC II, TU Munchen, Lichtenbergstr 4, D 85747 Garching, Germany
    Protein Sci 13:2378-87. 2004
    E. coli Par10 is a peptidyl-prolyl cis/trans isomerase (PPIase) from Escherichia coli catalyzing the isomerization of Xaa-Pro bonds in oligopeptides with a broad substrate specificity. The structure of E...
  81. ncbi Functional conservation of phosphorylation-specific prolyl isomerases in plants
    J L Yao
    Horticulture and Food Research Institute of New Zealand, Private Bag, 92169 Auckland, New Zealand
    J Biol Chem 276:13517-23. 2001
    The phosphorylation-specific peptidyl prolyl cis/trans isomerase (PPIase) Pin1 in humans and its homologues in yeast and animal species play an important role in cell cycle regulation...
  82. doi A novel method for monitoring glucocorticoid-induced changes of the glucocorticoid receptor in kidney transplant recipients
    Yan Chen
    University of Southern California, Los Angeles, CA, USA
    Transpl Immunol 20:249-52. 2009
    ....
  83. ncbi Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A
    M Milad
    Department of Biochemistry and Molecular Biology, Mayo Medical School, Rochester, Minnesota 55905, USA
    Mol Endocrinol 9:838-47. 1995
    ..P23 is a novel protein of unknown function and p54 or FKBP54 has been recently shown to be another FK506-binding protein related to p59...
  84. ncbi The Aspergillus niger cypA gene encodes a cyclophilin that mediates sensitivity to the immunosuppressant cyclosporin A
    P M Derkx
    Danisco Cultor Innovation Copenhagen, PO Box 17, Langebrogade 1, DK 1001, Copenhagen, Denmark
    Mol Genet Genomics 266:527-36. 2001
    ..and characterization of a gene, cypA, from Aspergillus niger that encodes a peptidyl prolyl cis-trans isomerase (PPIase) belonging to the cyclophilin family...
  85. ncbi Characterization of native and recombinant peptidyl prolyl cis-trans isomerases derived from Methanococcus thermolithotrophicus based on cDNA sequence
    K Murayama
    Division of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, Tokyo, Japan
    Electrophoresis 21:1733-9. 2000
    ..In this study, recombinant protein for native peptidyl prolyl cis-trans isomerase (N-PPIase) and double-labeled (13C- and 15N-) protein (DL-PPIase) appeared on the sodium dodecyl sulfate (SDS) ..
  86. pmc Neisseria meningitidis encodes an FK506-inhibitable rotamase
    B A Sampson
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021 6399
    Proc Natl Acad Sci U S A 89:1164-8. 1992
    ..In prokaryotes homologs of cyclophilins have been identified and found to have rotamase activity...
  87. ncbi Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation
    W D Jarvis
    Department of Medicine, Medical College of Virginia, Richmond, Virginia, USA
    J Pharmacol Exp Ther 290:1384-92. 1999
    ..was associated with phosphorylation and activation of the c-Jun NH(2)-terminal kinase (JNK1) SAPK enzymes p46 and p54-JNK2 and transient increases in expression of the transcription factor c-Jun, a primary JNK substrate...
  88. doi Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 93:99-110. 2011
    ..Large immunophilins, FKBP51 and FKBP52 are also co-chaperones of Hsp90-tau complexes...
  89. ncbi Extended binding sites of cyclophilin as revealed by the interaction with HIV-1 Gag polyprotein derived oligopeptides
    M Schutkowski
    Max Planck Gesellschaft zur Förderung der Wissenschaften e V, Arbeitsgruppe Enzymologie der Peptidbindung, Halle Saale, Germany
    FEBS Lett 394:289-94. 1996
    ..putative binding region for the complex of Pr55gag and the human cytosolic peptidyl prolyl cis/trans isomerase (PPIase) 18 kDa cyclophilin (Cyp18)...
  90. pmc Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires
    Trevor J Pemberton
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    BMC Genomics 7:244. 2006
    The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis/trans isomerisation ..
  91. doi hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures
    Marija Marko
    RNA Processing Laboratory, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635 Athens, Greece
    Exp Cell Res 316:390-400. 2010
    ..and pull-down assays, we have identified PSF (polypyrimidine tract-binding protein-associated splicing factor) and p54(nrb), two highly related proteins involved in transcription and RNA processing, as new binding partners of hnRNP M...
  92. ncbi Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe
    H K Huang
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Sci 114:3779-88. 2001
    Pin1/Ess1p is a highly conserved WW domain-containing peptidyl-prolyl isomerase (PPIase); its WW domain binds specifically to phospho-Ser/Thr-Pro sequences and its catalytic domain isomerizes phospho-Ser/Thr-Pro bonds...
  93. ncbi Immunophilin AtFKBP13 sustains all peptidyl-prolyl isomerase activity in the thylakoid lumen from Arabidopsis thaliana deficient in AtCYP20-2
    Anna Edvardsson
    Division of Cell Biology, Linkoping University, SE 581 85 Linkoping, Sweden
    Biochemistry 46:9432-42. 2007
    The physiological roles of immunophilins are unclear, but many possess peptidyl-prolyl isomerase (PPIase) activity, and they have been found in all organisms examined to date, implying that they are involved in fundamental, protein-..
  94. doi Peptidyl-prolyl isomerase activity in chloroplast thylakoid lumen is a dispensable function of immunophilins in Arabidopsis thaliana
    Björn Ingelsson
    Department of Clinical and Experimental Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Plant Cell Physiol 50:1801-14. 2009
    ..folding catalysts, although only two of them, AtFKBP13 and AtCYP20-2, possess peptidyl-prolyl cis/trans isomerase (PPIase) activity...
  95. ncbi The regulation of type 7 adenylyl cyclase by its C1b region and Escherichia coli peptidylprolyl isomerase, SlyD
    S Z Yan
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 276:8500-6. 2001
    ..Escherichia coli SlyD protein, a cis-trans peptidylprolyl isomerase (PPIase), copurifies with AC7 C1b (7C1b)...
  96. pmc Cyclophilin A (CyPA) induces chemotaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CyPA and the ectodomain of CD147
    Fei Song
    Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer Biology, Xijing Hospital, The Fourth Military Medical University, 17 West Changle Road, Xi an 710032, China
    J Biol Chem 286:8197-203. 2011
    Cyclophilin A (CyPA) is a ubiquitously distributed peptidylprolyl cis-trans isomerase (PPIase) that possesses diverse biological functions...
  97. ncbi Isoforms of Jun kinase are differentially expressed and activated in human monocyte/macrophage (THP-1) cells
    S C Dreskin
    Division of Allergy and Clinical Immunology, and Division of Nephrology, Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 166:5646-53. 2001
    ..cellular responses to LPS, including enhanced activation of total JNK activity and increased phosphorylation of p54 JNK as well as p46 JNK...
  98. pmc The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1
    W M Yang
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    EMBO J 20:4814-25. 2001
    ..that belong to a subgroup of proteins, known as immunophilins, with peptidylprolyl cis-trans isomerase (PPIase) activity...
  99. ncbi Structural analysis of the mitotic regulator hPin1 in solution: insights into domain architecture and substrate binding
    Elena Bayer
    Max Planck Institute for Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    J Biol Chem 278:26183-93. 2003
    ..We have determined the solution structure of the two domain protein hPin1-(1-163) and its separately expressed PPIase domain (50-163) (hPin1PPIase) with an root mean square deviation of <0.5 A over backbone atoms using NMR...
  100. doi Response of the adipose tissue transcriptome to dihydrotestosterone in mice
    Yonghua Zhang
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Quebec, Canada
    Physiol Genomics 35:254-61. 2008
    ....
  101. pmc Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly
    Nicola Minshall
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    Mol Biol Cell 20:2464-72. 2009
    The RNA helicase p54 (DDX6, Dhh1, Me31B, Cgh-1, RCK) is a prototypic component of P-(rocessing) bodies in cells ranging from yeast to human...

Research Grants60

  1. IMMUNOPHILIN INTERACTIONS WITH STEROID RECEPTORS
    David Smith; Fiscal Year: 2006
    ..Over the last few years, evidence has accumulated that two of the immunophilins, FKBP52 and FKBP51, can increase or decrease, respectively, the hormone binding affinity (HBA) of glucocorticoid receptor (GR)...
  2. Role of calcineurin in store-operated calcium entry of pulmonary endothelium
    AUDREY ANNE VASAUSKAS; Fiscal Year: 2013
    ..CN is inhibited by the immunophilin FKBP51-FK506 immunosuppressant drug complex...
  3. Chad A Dickey; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Hsp90-associated enzyme-FK506 binding protein 51 (FKBP51)-was recently found to co-localize with tau in neurons and physically interact with the microtubule (MT)-associated protein tau in brain ..
  4. THE ROLE OF PIN1 IN MITOSIS WITH DESIGNED INHIBITORS
    FELICIA ETZKORN; Fiscal Year: 2002
    ..the folding process is accelerated by the peptidyl-prolyl isomerase (PPIase enzymes)...
  5. Pharmacogenomics and Mechanisms of Cytidine Analogues
    Liewei Wang; Fiscal Year: 2013
    ....
  6. Donna L Cioffi; Fiscal Year: 2016
    ..goal of the proposed research is to determine the mechanisms by which the large, molecular weight immunophilins, FKBP51 and FKBP52, regulate store-operated calcium (SOC) entry in pulmonary endothelial cells...
  7. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..a promising approach that involves regulation of GR by tetratricopeptide repeat (TPR) proteins, such as FKBP52, FKBP51, Cyp40 and PP5...
  8. Social, Genetic Determinants of Blood Pressure in Underserved African Americans
    SANDRA MARIE COULON; Fiscal Year: 2013
    ....
  9. Joel D Richter; Fiscal Year: 2015
    ..Translational control by CPEB regulates not only early development, but neuronal synaptic cellular senescence as well. Thus, these experiments have important implications of human infertility, neurodegeneration, and cancer etiology. ..
  10. Yeast Ess1, a Conserved PPlase Essential for Mitosis
    Steven D Hanes; Fiscal Year: 2010
    ..One exception is a PPIase called Ess1, which is essential for growth in the yeast, Saccharomyces cerevisiae...
  11. Bekh Bradley; Fiscal Year: 2014
    ..It is anticipated that these findings may be helpful towards mitigating risk factors and promoting resilience to traumatic stressors. ..
  12. The Importance of Prolyl 3-hydroxylation in recessive Osteogenesis Imperfecta
    ERICA PAIGE HOMAN; Fiscal Year: 2013
    ..In addition to its function as a 3-hydroxylase, CypB functions as a cis/trans isomerase (PPIase)[9]...
  13. STEVEN M M SOUTHWICK; Fiscal Year: 2015
    ..Findings on risk factors can be used to improve future prevention and treatment strategies, while findings on protective factors can be applied to bolster resilience in rescue and recovery workers prior to trauma exposure. ..
  14. Genetic and Molecular Analyses of Protein Biogenesis in the Neuroretina
    Paulo A Ferreira; Fiscal Year: 2013
    ..Aim 3. Test the hypothesis that the cis-trans prolyl isomerase (PPIase) activity in the CY domain of RanBP2 controls the biogenesis of selective proteins that are critical to the ..
  15. Kerry J Ressler; Fiscal Year: 2016
    ..Such a strategy has the potential to help redefine psychobiological subtypes of PTSD as well as to reduce the burden of chronic PTSD on our healthcare system. ..
  16. Charles B Nemeroff; Fiscal Year: 2016
    ..Such a strategy has the potential to help redefine psychobiological subtypes of PTSD as well as to reduce the burden of chronic PTSD on our healthcare system. ..
  17. STACY SCHMIDT DRURY; Fiscal Year: 2016
    ....
  18. Developmental Pathways to Suicide Attempt
    Holly C Wilcox; Fiscal Year: 2012
    ....
  19. Neuroendophenotypes and Risk for Posttraumatic Stress Disorder
    Negar Fani; Fiscal Year: 2012
    ..I will also examine of associations among FKBP5 genetic status, childhood maltreatment history, and WM integrity in the AF, CB, and CC (using Diffusion Tensor Imaging) in individuals with variable PTSD symptoms. ..
  20. LACCASE REGULATION AND VIRULENCE IN CRYPTOCOCCUS
    James Cook; Fiscal Year: 2009
    ..In Specific Aim 1, we will assess for functional conservation of VAD1 within the RCK/p54 protein subfamily of DEXD/H box proteins to which Vad1 exhibits significant homology...
  21. ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS.
    NICHOLAS DAVIDSON; Fiscal Year: 2009
    ..The number and identity of these factors is unknown. We have used a two-hybrid screen to clone a candidate factor, p54, whose interactions, distribution and function make it a candidate apo B RNA editing associated protein...
  22. Designed Inhibitors of Pin1 in Mitosis
    FELICIA ETZKORN; Fiscal Year: 2009
    ..The unique peptidyl-prolyl isomerase (PPIase) enzymatic activity of Pin1 in the regulation of biological processes is interesting for fundamental reasons...
  23. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
    ..phosphatase (ALP), ATPase, nucleotide triphosphate pyrophosphohydrolase (NTPPase) and inorganic pyrophosphatase (PPiase), in regulating the mineralization of isolated MVs from rat growth plate, and in promoting or inhibiting in vivo ..
  24. Role of FKBP52 in androgen signaling and hypospadias
    Weinian Shou; Fiscal Year: 2009
    ..In the GR system, FKBP52 is known to increase the binding affinity for hormone, while FKBP51 (a closely-related SRA-TPR) serves to attenuate (but not abolish) this function...
  25. CATALYZED AMIDE ISOMERIZATION: SYNTHETIC ROTAMASES
    Thomas Lectka; Fiscal Year: 2001
    ..mild, selective catalysts for amide isomerization (AI), culminating in the systematic development of model rotamase enzymes that catalyze the folding of peptides through the cis-trans isomerization of proline residues...
  26. STRUCTURE/FUNCTION ANALYSIS OF MITOTIC REGULATORS
    JOSEPH NOEL; Fiscal Year: 2001
    ..The human peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 is a conserved mitotic regulator essential for the G2 to M transition of the eukaryotic cell cycle...
  27. TOWARDS RATIONALLY DESIGNED IMMUNOSUPPRESSANTS
    TIMOTHY CURRAN; Fiscal Year: 1992
    ..when it is bound to cyclophilin, a cytoplasmic protein that possesses peptidyl prolyl cis-trans isomerase (rotamase) enzymatic activity...
  28. Role of the Prolylisomerase Pin1 in Oncogenesis
    Gerburg Wulf; Fiscal Year: 2007
    ..4) To study the effect of the inhibition of Pin1's PPIase activity as potential cancer therapy in vitro and in vivo...
  29. STRUCTURE/FUNCTION OF HIV1 CAPSID/CYCLOPHILIN COMPLEX
    Wesley Sundquist; Fiscal Year: 2001
    ..of Pro90 in CA bound to cyclophilin A suggests that this residue may act as a substrate for cyclophilin rotamase activity...
  30. MOLECULAR MECHANISMS OF DELAYED PRECONDITIONING
    RAKESH KUKREJA; Fiscal Year: 2006
    ..that rapid pacing triggers signaling pathway leading to the phosphorylation of p38, p44/p42 (ERK I & 2) and p46/p54 JNK kinases. Using selective blockers we will determine the role of these kinase(s) in cardioprotection...
  31. AN ANIMAL MODEL OF GLUCOCORTICOID RESISTANCE
    Jonathan Scammell; Fiscal Year: 2007
    ..monkeys results from over expression of a potent form of the glucocorticoid receptor-associated cochaperone FKBP51. This finding has uncovered a novel function of this FK506-binding immunophilin, which results in a dramatic ..
  32. ACISR - Early-Onset Mood & Anxiety Disorder
    David Brent; Fiscal Year: 2006
    ..The Center will enhance the development of the next generation of intervention and services researchers and will disseminate new research information to families, practitioners, and researchers. ..
  33. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    David Brent; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study [unreadable] [unreadable]..
  34. TESTING THE EXERCISE PLUS PROGRAM FOLLOWING HIP FRACTURE
    Barbara Resnick; Fiscal Year: 2002
    ....
  35. eNOS: Metabolism & Vascular Biology in Health & Disease
    M Laughlin; Fiscal Year: 2007
    ..The strong group of investigators submitting this application is uniquely qualified and prepared to accomplish these goals. ..
  36. The Role of PP2A in Yeast Cell Cycle Progression
    Yu Jiang; Fiscal Year: 2009
    ..To test the hypothesis that the Tap42-PP2Ac complex controls the G2 gene expression through the Fkh1/2 transcription factors. This study is part of our long-term goals to understand the role of PP2A in cell growth control. ..
  37. Testing a Restorative Care Nursing Program
    Barbara Resnick; Fiscal Year: 2006
    ..The ultimate goal is to alter the current philosophy of care in long-term care to focus on function, improve clinical outcomes, and inform policy makers on the effectiveness of restorative care programs. ..
  38. TPR Proteins in Steroid Receptor Signaling & Physiology
    EDWIN SANCHEZ; Fiscal Year: 2009
    ..the chaperone Hsp90 which in turn can be bound by one of four tetratricopeptide repeat (TPR) proteins: FKBP52, FKBP51, Cyp40 and PP5. This fact means that SRs exists in distinct heteromeric complexes defined by TPR protein content...
  39. Molecular basis of arsenic-induced cell transformation
    Zigang Dong; Fiscal Year: 2007
    ..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
  40. Cardiomyocyte Signaling Through Focal Adhesion
    MARIA HEIDKAMP; Fiscal Year: 2003
    ..Their effects on FAF and SA will be investigated. A better understanding of the signaling pathways which contribute to cardiac hypertrophy would enable novel, therapeutic agents of disease prevention to be discovered. ..
  41. Interactions between ocular tissue and RSV
    Sailen Barik; Fiscal Year: 2004
    ..be proven, it would establish an animal model for RSV-eye interaction, and open new directions in ocular immunopathology, RNA virus-activated signaling pathways in the eye, and antiviral drug regimen targeting the eye ..
  42. HEAT SHOCK AND STEROID RECEPTOR SIGNALING
    EDWIN SANCHEZ; Fiscal Year: 2005
    ....
  43. Severe Asthma and the Glucocorticoid Receptor Complex
    Gregory Hawkins; Fiscal Year: 2006
    ..This will also lay the ground work for future functional studies using coding sequence variants identified in the GR complex proteins. [unreadable] [unreadable] [unreadable]..
  44. 2007 Vascular Cell Biology Gordon Research Conference
    Bradford Berk; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2009
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  46. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2007
    ....
  47. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  48. Peri-Partum Depression and Genetics of Glucocorticoid Receptor Regulating Genes
    Elisabeth Binder; Fiscal Year: 2007
    ..Such 'a priori' identification of women at risk will directly contribute to treatment planning and enhancement of perinatal health, obstetrical outcome, and infant well-being. [unreadable] [unreadable] [unreadable]..
  49. Physiological Roles of Receptor-Associated Immunophilins
    MARC COX; Fiscal Year: 2007
    ..The goals of this project are to understand roles of the steroid hormone receptor-associated immunophilins (FKBP51 and FKBP52) in glucocorticoid receptor (GR)-mediated physiological processes, and to assess the likelihood that ..
  50. REGULATION OF THE CAMP SPECIFIC PHOSPHODIESTERASES
    Graeme Bolger; Fiscal Year: 2003
    ..5. The two-hybrid system will be used to clone cDNAs encoding proteins that interact with 4 novel PDE4 isoforms. ..
  51. REVERSIBLE PROTEIN PHOSPHORYLATION IN APICOMPLEXANS
    Sailen Barik; Fiscal Year: 2004
    ..These results should form the cornerstone in the detailed elucidation of the regulatory pathways and possible drug-target interactions in Plasmodium in particular, and Apicomplexans in general. ..
  52. CARDIOVASCULAR RESEARCH TRAINING
    Bradford Berk; Fiscal Year: 2004
    ..The University of Rochester is a research-intensive institution with a long tradition and commitment to training investigators which should facilitate the success of this program in cardiovascular research. ..
  53. Study on Ultraviolet-induced Signal Transduction
    Zigang Dong; Fiscal Year: 2010
    ..These preclinical studies are designed to lead to the development of new strategies for the chemoprevention of human skin cancers. ..
  54. Novel Polyamine-conjugated Dendrimers for Pretargeted Chemotherapy of Ovarian Can
    SRINATH PALAKURTHI; Fiscal Year: 2006
    ..This novel approach reduces the toxic side effects associated with the chemotherapeutics used for the ovarian cancer treatment. [unreadable] [unreadable] [unreadable] [unreadable]..
  55. Mechanisms of RNA virus-host interaction
    Sailen Barik; Fiscal Year: 2009
    ..Together, these results should lead to a better understanding of the replication of RSV in particular and of RNA viruses in general, and pave the way for a more reliable management of the viral diseases. ..
  56. Viral Stress-inducible Gene Expression
    Ganes Sen; Fiscal Year: 2005
    ..These studies will illuminate the modes of cross-talk between the TLR and the Jak-STAT signaling pathways for appropriate gene induction in virus-infected cells. ..
  57. Regulation of mTOR by Mechanically-Induced Signal Events
    TROY HORNBERGER; Fiscal Year: 2006
    ..abstract_text> ..
  58. Docking Site Mutations in the Fe-and MoFe-proteins.
    Nara Gavini; Fiscal Year: 2002
    ..We believe that these studies will provide new insights regarding how the components of this complex metalloenzyme maintain such high specificity in their interactions. ..
  59. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2010
    ..abstract_text> ..