FGFR2

Summary

Gene Symbol: FGFR2
Description: fibroblast growth factor receptor 2
Alias: BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2, BEK fibroblast growth factor receptor, bacteria-expressed kinase, keratinocyte growth factor receptor, protein tyrosine kinase, receptor like 14
Species: human

Top Publications

  1. pmc Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene
    T Miki
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:246-50. 1992
  2. doi FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
    Kaiko Kunii
    Pharmacology, Merck Research Laboratories, Boston, MA 02115, USA
    Cancer Res 68:2340-8. 2008
  3. doi Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
  4. ncbi Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line
    Anne Goriely
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Science 301:643-6. 2003
  5. pmc Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
    Petra E A Huijts
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res 9:R78. 2007
  6. pmc K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes
    Y Hattori
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Proc Natl Acad Sci U S A 87:5983-7. 1990
  7. ncbi Cancer genomics and genetics of FGFR2 (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Chuo Ward, Tokyo 104 0045, Japan
    Int J Oncol 33:233-7. 2008
  8. pmc Paternal origin of FGFR2 mutations in sporadic cases of Crouzon syndrome and Pfeiffer syndrome
    R L Glaser
    Department of Pediatrics, Center for Craniofacial Development and Disorders, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 66:768-77. 2000
  9. ncbi Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs
    T Ueda
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 59:6080-6. 1999
  10. ncbi A novel insertion in the FGFR2 gene in a patient with Crouzon phenotype and sacrococcygeal tail
    Pablo Lapunzina
    Section of Medical Genetics, Hospital Universitario La Paz, 28046 Madrid, Spain
    Birth Defects Res A Clin Mol Teratol 73:61-4. 2005

Research Grants

  1. Rashmi Bansal; Fiscal Year: 2016
  2. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
  3. MARJA MARIE HURLEY; Fiscal Year: 2016
  4. FIBROBLAST GROWTH FACTOR RECEPTORS IN CRANIOSYNOSTOSIS
    ETHYLIN JABS; Fiscal Year: 1999
  5. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
  6. Jacob V P Eswarakumar; Fiscal Year: 2014
  7. PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2012
  8. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
  9. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert E Friesel; Fiscal Year: 2011
  10. Moosa Mohammadi; Fiscal Year: 2016

Detail Information

Publications248 found, 100 shown here

  1. pmc Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene
    T Miki
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:246-50. 1992
    Expression cDNA cloning and structural analysis of the human keratinocyte growth factor receptor (KGFR) revealed identity with one of the fibroblast growth factor (FGF) receptors encoded by the bek gene (FGFR-2), except for a divergent ..
  2. doi FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
    Kaiko Kunii
    Pharmacology, Merck Research Laboratories, Boston, MA 02115, USA
    Cancer Res 68:2340-8. 2008
    ..In a panel of gastric cancer cell lines, fibroblast growth factor receptor 2 (FGFR2) was overexpressed and tyrosine phosphorylated selectively in FGFR2-amplified cell lines ..
  3. doi Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
    ..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
  4. ncbi Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line
    Anne Goriely
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Science 301:643-6. 2003
    ..Here, we describe a sensitive method to quantify substitutions at nucleotide 755 of the fibroblast growth factor receptor 2 (FGFR2) gene in sperm...
  5. pmc Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
    Petra E A Huijts
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res 9:R78. 2007
    ..Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer...
  6. pmc K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes
    Y Hattori
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Proc Natl Acad Sci U S A 87:5983-7. 1990
    ..The K-sam gene had significant homologies with bek, FLG, and chicken basic fibroblast growth factor receptor gene...
  7. ncbi Cancer genomics and genetics of FGFR2 (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Chuo Ward, Tokyo 104 0045, Japan
    Int J Oncol 33:233-7. 2008
    b>FGFR2 gene encodes FGFR2b in epithelial cells, and FGFR2c in mesenchymal cells. FGFR2b is a high affinity receptor for FGF1, FGF3, FGF7, FGF10 and FGF22, while FGFR2c for FGF1, FGF2, FGF4, FGF6, FGF9, FGF16 and FGF20...
  8. pmc Paternal origin of FGFR2 mutations in sporadic cases of Crouzon syndrome and Pfeiffer syndrome
    R L Glaser
    Department of Pediatrics, Center for Craniofacial Development and Disorders, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 66:768-77. 2000
    ..are both autosomal dominant craniosynostotic disorders that can be caused by mutations in the fibroblast growth factor receptor 2 (FGFR2) gene...
  9. ncbi Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs
    T Ueda
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 59:6080-6. 1999
    ..as an amplified gene from human gastric cancer cell line KATOIII, and its product is identical to fibroblast growth factor receptor 2. The K-sam gene is located on human chromosome 10q26 and is preferentially amplified in the poorly ..
  10. ncbi A novel insertion in the FGFR2 gene in a patient with Crouzon phenotype and sacrococcygeal tail
    Pablo Lapunzina
    Section of Medical Genetics, Hospital Universitario La Paz, 28046 Madrid, Spain
    Birth Defects Res A Clin Mol Teratol 73:61-4. 2005
    Mutations in the FGFR2 gene are present in several syndromes with craniosynostosis, such as Pfeiffer's, Apert's, and Crouzon's.
  11. doi Expression and signaling of the tyrosine kinase FGFR2b/KGFR regulates phagocytosis and melanosome uptake in human keratinocytes
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Rome, Italy
    FASEB J 25:170-81. 2011
    ..growth factor KGF/FGF7 promotes the melanosome uptake through activation of its receptor tyrosine kinase FGFR2b/KGFR. The aim of the present study was to investigate the contribution of KGFR expression, activation, and signaling in ..
  12. ncbi Ocular abnormalities in Apert syndrome: genotype/phenotype correlations with fibroblast growth factor receptor type 2 mutations
    Suzanne K Jadico
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J AAPOS 10:521-7. 2006
    ..and other craniofacial malformations, is caused by point mutations (Ser252Trp or Pro253Arg) in the fibroblast growth factor receptor 2 gene...
  13. pmc Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
    Veronica C Ardi
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:25854-66. 2009
    ....
  14. doi Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis
    Hichem Miraoui
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, Paris, France
    Hum Mol Genet 19:1678-89. 2010
    ..In this study, we have used microarray analysis to investigate the signaling pathways that are activated by FGFR2 mutations in Apert craniosynostosis...
  15. doi Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women
    Jie Liang
    Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing, China
    Carcinogenesis 29:2341-6. 2008
    b>Fibroblast growth factor receptor 2 (FGFR2) belongs to the FGFR family, which plays an important role in cell growth, invasiveness, motility and angiogenesis...
  16. ncbi Fibroblast growth factor receptor 2 (FGFR2): genomic sequence and variations
    R G Ingersoll
    Institute of Genetic Medicine, Center for Craniofacial Development and Disorders, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore 21287 3914, USA
    Cytogenet Cell Genet 94:121-6. 2001
    Fibroblast growth factor receptors (FGFRs) play an important role in development and tumorigenesis. Mutations in FGFR2 cause more than five craniosynostosis syndromes. The FGFR2 genomic structure is the largest of the FGFR family...
  17. ncbi FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1155-9. 2003
    ..b>FGFR2 gene on human chromosome 10q26 is amplified in diffuse-type gastric cancer, while WDR11 gene on human chromosome ..
  18. ncbi Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells
    Allison B Moffa
    Cellular and Molecular Biology Graduate Program, University of Michigan Health System, Ann Arbor, MI, USA
    Mol Cancer Res 2:643-52. 2004
    ..our laboratory (SUM-52PE) has a 12-fold amplification and high-level overexpression of the oncogene fibroblast growth factor receptor 2 (FGFR2)...
  19. ncbi Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome
    K A Przylepa
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Genet 13:492-4. 1996
    ..Mutations in Crouzon, Jackson-Weiss, Pfeiffer and Apert syndromes have been reported in the FGFR2 extracellular domain...
  20. ncbi Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Ca(v)1.3)
    R Rosenthal
    Institut für Klinische Physiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    FASEB J 15:970-7. 2001
    In contrast to the fibroblast growth factor receptor 1 (FGFR1), little is known about intracellular signaling of FGFR2. The signaling cascade of FGFR2 was studied using the perforated patch configuration of the patch-clamp technique in ..
  21. ncbi Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling
    P J Marie
    INSERM U349, Hopital Lariboisiere, Paris, France
    Histol Histopathol 17:877-85. 2002
    ....
  22. ncbi Clinically mild, atypical, and aged craniofacial syndrome is diagnosed as Crouzon syndrome by identification of a point mutation in the fibroblast growth factor receptor 2 gene (FGFR2)
    Toyoki Maeda
    Division of Molecular and Clinical Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Higashi ku, Maidashi, Fukuoka 812 8582
    Intern Med 43:432-5. 2004
    ..A point mutation in fibroblast growth factor receptor 2 (FGFR2) was identified that had previously been seen only in sporadic cases of Crouzon syndrome...
  23. ncbi P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation
    Tiziano Baroni
    Institute of Histology and General Embryology, University of Perugia, Perugia, Italy
    J Cell Physiol 202:524-35. 2005
    ..fibroblast growth factor 2 (FGF2) signaling caused by mutations in the fibroblast growth factor receptor (FGFR2) leads to human craniosynostosis such as the Apert syndrome...
  24. ncbi The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
    ..Our findings support the hypothesis that there are two different FGFR-1- and FGFR-2-dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD...
  25. ncbi Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes
    Christopher J Robinson
    Cancer Research UK and Department of Medical Oncology, University of Manchester, Christie Hospital National Health Service Trust, Wilmslow Road, Manchester M20 4BX
    J Biol Chem 280:42274-82. 2005
    ..A cooperative mechanism of FGF1 dimerization could explain how 2:2:1 signaling complexes form at the cell surface, an environment rich in heparan sulfate...
  26. ncbi The neural cell adhesion molecule binds to fibroblast growth factor receptor 2
    Claus Christensen
    Protein Laboratory, Copenhagen University, Denmark
    FEBS Lett 580:3386-90. 2006
    ..In this study, we show by surface plasmon resonance analysis that NCAM can bind to FGFR2 with an affinity similar to that for the NCAM-FGFR1 interaction...
  27. pmc Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway
    Imad Shams
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell Biol 27:6903-12. 2007
    ..studies have implicated heterozygous mutations in fibroblast growth factor 10 (FGF10) and in FGF receptor 2 (FGFR2) in LADD syndrome...
  28. doi Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis
    Sebastián Giulianelli
    Laboratory of Hormonal Carcinogenesis, Institute of Experimental Biology and Medicine IBYME National Research Council of Argentina CONICET, Buenos Aires, Argentina
    Int J Cancer 123:2518-31. 2008
    ..In summary, this is the first study reporting differences between CAF from HD and HI tumors suggesting that CAF-HI actively participate in driving HI tumor growth...
  29. pmc Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
    M C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:30-6. 2009
    ..17 (95% CI 1.06-1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia.
  30. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  31. pmc Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues
    Y A Luqmani
    Department of Medical Oncology, Charing Cross Hospital Medical School, London, UK
    Br J Cancer 66:273-80. 1992
    The expression of basic fibroblast growth factor (bFGF) and two of its receptors, FGFR1 and FGFR2, was detected using the polymerase chain reaction, and quantified by comparison to the relative amount of product obtained following co-..
  32. pmc Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy
    G Yan
    W Alton Jones Cell Science Center, Inc, Lake Placid, New York 12946
    Mol Cell Biol 13:4513-22. 1993
    ..Multiple autocrine and potentially intracrine ligand-receptor loops resulting from these alterations within the FGF-FGF-R family may underlie the autonomy of malignant tumor cells...
  33. ncbi Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome
    A O Wilkie
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Nat Genet 9:165-72. 1995
    ..Pro253Arg) in the linker between the second and third extracellular immunoglobulin (Ig) domains of fibroblast growth factor receptor 2 (FGFR2) in all 40 unrelated cases of Apert syndrome studied...
  34. ncbi Structural and functional diversity in the FGF receptor multigene family
    D E Johnson
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Adv Cancer Res 60:1-41. 1993
  35. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways...
  36. ncbi Exclusive paternal origin of new mutations in Apert syndrome
    D M Moloney
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Nat Genet 13:48-53. 1996
    ..from one or other of two specific nucleotide substitutions, both C-->G transversions, in the fibroblast growth factor receptor 2 (FGFR2) gene...
  37. ncbi Trp290Cys mutation in exon IIIa of the fibroblast growth factor receptor 2 (FGFR2) gene is associated with Pfeiffer syndrome
    M Tartaglia
    Laboratorio di Biologia Cellulare, Istituto Superiore di Sanita, Rome, Italy
    Hum Genet 99:602-6. 1997
    ..Mutations in the genes encoding fibroblast growth factor receptors 1 and 2 (FGFR1 and FGFR2) have recently been implicated in the aetiology of such a syndrome, as well as of other craniosynostotic ..
  38. ncbi Modulation of keratinocyte growth factor receptor expression in human cultured keratinocytes
    C Marchese
    Istituto Nazionale Ricerca sul Cancro di Genova, Sezione di Biotecnologie, Rome, Italy
    Cell Growth Differ 8:989-97. 1997
    ..biological effects through binding to the KGF receptor (KGFR), a splicing transcript variant of FGF receptor 2 (FGFR2)...
  39. ncbi Analysis of the mutational spectrum of the FGFR2 gene in Pfeiffer syndrome
    L R Cornejo-Roldan
    Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, USA
    Hum Genet 104:425-31. 1999
    ..correlated with specific mutations in the human fibroblast growth factor receptor (FGFR) genes, FGFR1 and FGFR2. In this study, we set out to examine the exons in FGFR2 most commonly associated with mutations in PS, exons IIIa ..
  40. ncbi A novel mutation, Ala315Ser, in FGFR2: a gene-environment interaction leading to craniosynostosis?
    D Johnson
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Eur J Hum Genet 8:571-7. 2000
    ..We describe a novel heterozygous mutation of FGFR2 (943G --> T, encoding the amino acid substitution Ala315Ser) in a girl with non-syndromic unicoronal ..
  41. ncbi FGF2 promotes skeletogenic differentiation of cranial neural crest cells
    S Sarkar
    Developmental Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Development 128:2143-52. 2001
    ..In longer-term cultures, both endochondral and membrane bone are formed. FGFR1, FGFR2 and FGFR3 are all detectable by immunohistochemistry in the mesencephalic region, with particularly intense ..
  42. ncbi Mutation in the FGFR2 gene in a Taiwanese patient with Beare-Stevenson cutis gyrata syndrome
    T J Wang
    Department of Paediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Clin Genet 61:218-21. 2002
    ..Molecular genetic analysis of the FGFR2 gene in this patient's DNA revealed a missense A --> G mutation on nucleotide 1303 of the FGFR2 cDNA...
  43. ncbi A Non-sequence-specific double-stranded RNA structural element regulates splicing of two mutually exclusive exons of fibroblast growth factor receptor 2 (FGFR2)
    Stephanie J Muh
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6144, USA
    J Biol Chem 277:50143-54. 2002
    Alternative splicing of fibroblast growth factor receptor 2 (FGFR2) mutually exclusive exons IIIb and IIIc represents a tightly regulated and functionally relevant example of post-transcriptional gene regulation...
  44. pmc Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
    Omar A Ibrahimi
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Hum Mol Genet 13:2313-24. 2004
    Gain-of-function missense mutations in FGF receptor 2 (FGFR2) are responsible for a variety of craniosynostosis syndromes including Apert syndrome (AS), Pfeiffer syndrome (PS) and Crouzon syndrome (CS)...
  45. ncbi A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome
    Hind Guenou
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, Paris, University Paris 7, Hopital Lariboisiere, Paris, France
    Hum Mol Genet 14:1429-39. 2005
    ..In this study, we investigated the role of fibroblast growth factor receptor-2 (Fgfr2) in the abnormal osteoblast differentiation in SCS...
  46. ncbi Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations
    Andrew O M Wilkie
    Weatherall Institute of Molecular Medicine, NDCLS, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Cytokine Growth Factor Rev 16:187-203. 2005
    ..with FGFR1 and FGFR3 mutations; identification of fundamental differences in the cellular mechanisms of mutant FGFR2 and FGFR3 action; and the direct identification of FGFR2 and FGFR3 mutations in sperm...
  47. ncbi Mutation screening in patients with syndromic craniosynostoses indicates that a limited number of recurrent FGFR2 mutations accounts for severe forms of Pfeiffer syndrome
    Elisabeth Lajeunie
    1INSERM U 393, Hopital Necker Enfants Malades, Paris, France
    Eur J Hum Genet 14:289-98. 2006
    ..Mutations preferentially occurred in exons 8 and 10 of FGFR2 encoding the third Ig loop of the receptor...
  48. ncbi Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F
    Nan E Hatch
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 281:27292-305. 2006
    ..Additionally, we show that trafficking and autoactivation of wild type FGFR2 is glycosylation-dependent...
  49. ncbi AKT and MAPK signaling in KGF-treated and UVB-exposed human epidermal cells
    Lavinia Vittoria Lotti
    Department of Experimental Medicine, University Sapienza, Viale Regina Elena, Rome, Italy
    J Cell Physiol 212:633-42. 2007
    ..We also demostrated increasing expression of KGFR substrates, such as PAK4 during keratinocyte differentiation parallel to the receptor upregulation.
  50. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0...
  51. pmc hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc
    David M Mauger
    Box 3053 424 CARL, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Mol Cell Biol 28:5403-19. 2008
    ..In this study, we identify hnRNP H and hnRNP F proteins as being novel silencers of fibroblast growth factor receptor 2 exon IIIc...
  52. doi Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
    Sara A Byron
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
    Cancer Res 68:6902-7. 2008
    ..Because we have recently shown activating mutations in fibroblast growth factor receptor 2 (FGFR2) in 16% of endometrioid endometrial cancers, we sought to determine the genetic context in ..
  53. pmc Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women
    Timothy R Rebbeck
    Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Carcinogenesis 30:269-74. 2009
    b>FGFR2 and MAP3K1 are members of the RAS/RAF/MEK/ERK-signaling pathway and have been identified from genome-wide association studies to be breast cancer susceptibility genes...
  54. pmc Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
    Jiyoung Y Cha
    Lineberger Comprehensive Cancer Center, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 284:6227-40. 2009
    Alternative splice variants of fibroblast growth factor receptor 2 (FGFR2) IIIb, designated C1, C2, and C3, possess progressive reduction in their cytoplasmic carboxyl termini (822, 788, and 769 residues, respectively), with preferential ..
  55. ncbi Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma
    Takahiro Toyokawa
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Oncol Rep 21:875-80. 2009
    ..029). In conclusion, the co-expression of K-sam and KGF in gastric cancer might be a useful prognostic factor...
  56. pmc Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer
    Xuegong Zhu
    Department of Medicine, and the Endocrine Oncology Site Group, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 23:1397-405. 2009
    ..In particular, the disease-predisposing allele of FGFR2 is inherited as a 7.5-kb region within intron 2 that harbors eight single nucleotide polymorphisms...
  57. pmc Variation in the FGFR2 gene and the effects of postmenopausal hormone therapy on invasive breast cancer
    Ross L Prentice
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 18:3079-85. 2009
    ..Single nucleotide polymorphisms (SNP) in the fibroblast growth factor receptor 2 (FGFR2) gene are substantially associated with postmenopausal breast cancer risk and could ..
  58. ncbi Expression of fibroblast growth factor receptor 2 IIIc in human uterine cervical intraepithelial neoplasia and cervical cancer
    Rieko Kawase
    Department of Pathology, Integrative Oncological Pathology, Nippon Medical School, Tokyo 113 8602, Japan
    Int J Oncol 36:331-40. 2010
    Fibroblast growth factor receptors (FGFRs) 1-3 have IIIb and IIIc isoforms, and we reported that FGFR2 IIIb is highly expressed in cervical keratinizing squamous cell carcinoma (SCC)...
  59. ncbi Polymorphisms in second intron of the FGFR2 gene are associated with the risk of early-onset breast cancer in Chinese Han women
    Fangmeng Fu
    Department of General Surgery, Affiliated Union Hospital of Fujian Medical University, Union Clinical School, Fujian Medical University, Fuzhou, PR China
    Tohoku J Exp Med 226:221-9. 2012
    b>Fibroblast growth factor receptor 2 (FGFR2) plays an important role in tumor cell growth, invasiveness, motility, and angiogenesis...
  60. pmc FGFR2 point mutations in 466 endometrioid endometrial tumors: relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features
    Sara A Byron
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America
    PLoS ONE 7:e30801. 2012
    Mutations in multiple oncogenes including KRAS, CTNNB1, PIK3CA and FGFR2 have been identified in endometrial cancer...
  61. pmc Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation
    Toshiyuki Ishiwata
    Department of Pathology and Integrative Oncological Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Am J Pathol 180:1928-41. 2012
    ....
  62. ncbi Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop
    T Miki
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Science 251:72-5. 1991
    ..This expression cloning approach may be generally applicable to the isolation of genes that constitute limiting steps in mitogenic signaling pathways...
  63. pmc Analysis of phenotypic features and FGFR2 mutations in Apert syndrome
    W J Park
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Am J Hum Genet 57:321-8. 1995
    A phenotypic and genotypic survey was conducted on 36 Apert syndrome patients. In all but one patient, an FGFR2 mutation, either S252W or P253R, was found in exon IIIa (exon U or 7)...
  64. ncbi FGFR2 mutations in Pfeiffer syndrome
    E Lajeunie
    Nat Genet 9:108. 1995
  65. ncbi Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes
    P Rutland
    Mothercare Unit of Clinical Genetics, Institute of Child Health, London, UK
    Nat Genet 9:173-6. 1995
    Mutations in the fibroblast growth factor receptor 2 (FGFR2) gene have been identified in Crouzon syndrome, an autosomal dominant condition causing premature fusion of the cranial sutures (craniosynostosis)...
  66. ncbi Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2
    E W Jabs
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 3914
    Nat Genet 8:275-9. 1994
    ..Recently mutations in fibroblast growth factor receptor 2 (FGFR2) have been found in patients with another craniosynostotic syndrome, Crouzon syndrome...
  67. ncbi Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome
    W Reardon
    Mothercare Unit of Clinical Genetics and Fetal Medicine, Institute of Child Health, London, UK
    Nat Genet 8:98-103. 1994
    ..We now present evidence that mutations in the fibroblast growth factor receptor 2 gene (FGFR2) cause Crouzon syndrome...
  68. pmc Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA
    E Gilbert
    INSERM U211, Institut de Biologie, Centre Hospitalier Régional de Nantes, France
    Mol Cell Biol 13:5461-8. 1993
    The fibroblast growth factor receptor 2 gene pre-mRNA can be spliced by using either the K-SAM exon or the BEK exon. The exon chosen has a profound influence on the ligand-binding specificity of the receptor obtained...
  69. pmc FGFR2 exon IIIa and IIIc mutations in Crouzon, Jackson-Weiss, and Pfeiffer syndromes: evidence for missense changes, insertions, and a deletion due to alternative RNA splicing
    G A Meyers
    Center for Medical Genetics, Johns Hopkins Hospital, Baltimore, MD 21287 3914, USA
    Am J Hum Genet 58:491-8. 1996
    b>Fibroblast growth factor receptor 2 (FGFR2) mutations have been associated with the craniosynostotic conditions Crouzon, Jackson-Weiss, and Pfeiffer syndromes...
  70. ncbi Genotype-phenotype correlation for nucleotide substitutions in the IgII-IgIII linker of FGFR2
    M Oldridge
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 6:137-43. 1997
    Dominantly acting, allelic mutations of the fibroblast growth factor receptor 2 (FGFR2) gene have been described in five craniosynostosis syndromes...
  71. ncbi Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues
    S E Hughes
    Division of Histopathology, United Medical and Dental Schools, London, United Kingdom
    J Histochem Cytochem 45:1005-19. 1997
    ..a systematic analysis of the expression of the fibroblast growth factor receptor (FGFR) multigene family (FGFR1, FGFR2, FGFR3, and FGFR4) in archival serial sections of normal human adult tissues representing the major organ systems, ..
  72. ncbi The mutations in FGFR2-associated craniosynostoses are clustered in five structural elements of immunoglobulin-like domain III of the receptor
    D Steinberger
    Institut fur Humangenetik, Justus Liebig Universitat, Giessen, Germany
    Hum Genet 102:145-50. 1998
    Exons 5 and 7 of the fibroblast growth factor receptor 2 (FGFR2) gene code for immunoglobulin-like domain III (IgIII) and for the region connecting the second and the third Ig domain of the receptor...
  73. ncbi Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)
    M Igarashi
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 273:13230-5. 1998
    ..is unique among FGFs in that it binds and signals only through the FGF receptor (FGFR2b) isoform KGF receptor (KGFR) expressed specifically by epithelial cells...
  74. ncbi A novel FGFR2 gene mutation in Crouzon syndrome associated with apparent nonpenetrance
    E T Everett
    Department of Oral Facial Development, Indiana University School of Dentistry, Indianapolis 46202, USA
    Cleft Palate Craniofac J 36:533-41. 1999
    To determine whether specific mutations within the fibroblast growth factor receptor 2 (FGFR2) gene that are associated with Crouzon syndrome can be present in an individual who had been assumed to be "clinically normal."
  75. ncbi Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
    A N Plotnikov
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Cell 101:413-24. 2000
    ..with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively...
  76. ncbi Clustering of FGFR2 gene mutations inpatients with Pfeiffer and Crouzon syndromes (FGFR2-associated craniosynostoses)
    W Kress
    Department of Human Genetics, University of Wurzburg, Germany
    Cytogenet Cell Genet 91:134-7. 2000
    ..Mutations in FGFR2 were identified in 25 Crouzon and 5 Pfeiffer syndrome patients, whereas no sequence alterations were found in the ..
  77. ncbi Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    J H Jang
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cancer Res 61:3541-3. 2001
    ..Here we report two identical mutations in FGFR2 that cause craniosynostosis syndromes, Crouzon, Apert, and Pfeiffer in gastric carcinoma...
  78. pmc Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
    O A Ibrahimi
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:7182-7. 2001
    ..Two activating mutations, Ser-252 --> Trp and Pro-253 --> Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS...
  79. pmc Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis
    Shih hsin Kan
    Weatherall Institute of Molecular Medicine, The John Radcliffe Hospital, Oxford, United Kingdom
    Am J Hum Genet 70:472-86. 2002
    ..of three members of the fibroblast growth-factor-receptor family of signal-transduction molecules-namely, FGFR1, FGFR2, and FGFR3-contribute significantly to disorders of bone patterning and growth...
  80. ncbi The endocytic pathway followed by the keratinocyte growth factor receptor
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
    Histochem Cell Biol 118:1-10. 2002
    ..activates a receptor tyrosine kinase, the KGF receptor (KGFR), which is a splicing variant of the fibroblast growth factor receptor 2. The endocytic pathway followed by KGF and its receptor was analyzed here using immunofluorescence ..
  81. ncbi Inhibition of human bladder tumour cell growth by fibroblast growth factor receptor 2b is independent of its kinase activity. Involvement of the carboxy-terminal region of the receptor
    Isabelle Bernard-Pierrot
    UMR144, CNRS Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex, France
    Oncogene 23:9201-11. 2004
    The b isoform of fibroblast growth factor receptor 2, FGFR2b/FGFR2-IIIb/Ksam-IIC1/KGFR, a tyrosine kinase receptor, is expressed in a wide variety of epithelia and is downregulated in several human carcinomas including prostate, salivary ..
  82. pmc Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization
    Omar A Ibrahimi
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Biol 25:671-84. 2005
    ..Additionally, structural and biochemical analysis of an activating FGFR2 mutation resulting in Pfeiffer syndrome confirms the physiological significance of receptor-receptor contacts in ..
  83. pmc Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia
    Anne Goriely
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 102:6051-6. 2005
    ..C>G transversions at position 755 of FGF receptor 2 (FGFR2) cause Apert syndrome; this mutation, encoding the gain-of-function substitution Ser252Trp, occurs with a birth ..
  84. ncbi Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells
    Allison B Moffa
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, Michigan, USA
    J Cell Physiol 210:720-31. 2007
    Gene amplification and protein overexpression of fibroblast growth factor receptor 2 (FGFR2) characterize the SUM-52 breast cancer cell line developed in our laboratory...
  85. pmc Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer
    Kazumitsu Cho
    Department of Integrative Pathology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Am J Pathol 170:1964-74. 2007
    Keratinocyte growth factor (KGF) and KGF receptor (KGFR) have been implicated in cancer growth as well as tissue development and repair...
  86. pmc Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    P M Pollock
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA
    Oncogene 26:7158-62. 2007
    ..We have identified a total of 11 different FGFR2 mutations in 3/10 (30%) of endometrial cell lines and 19/187 (10%) of primary uterine tumors...
  87. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were ..
  88. ncbi The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer
    Tetsuo Kondo
    Department of Pathology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 13:4713-20. 2007
    ..We reported recently that FGF receptor 2 (FGFR2) is down-regulated through extensive DNA promoter methylation in thyroid cancer...
  89. ncbi Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy
    Traffic 8:1854-72. 2007
    The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/..
  90. doi Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis
    Jiyoung Y Cha
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Mol Cancer Res 6:435-45. 2008
    We identified the IIIb C2 epithelial cell-specific splice variant of fibroblast growth factor receptor 2 (FGFR2 IIIb C2) receptor tyrosine kinase in a screen for activated oncogenes expressed in T-47D human breast carcinoma cells...
  91. pmc Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ..A recent genome-wide association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in FGFR2 (rs2981582), TNRC9 (rs3803662), and MAP3K1 (rs889312) are associated with increased breast cancer risks in the ..
  92. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-..
  93. pmc Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer
    Kerstin B Meyer
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
    PLoS Biol 6:e108. 2008
    The recent whole-genome scan for breast cancer has revealed the FGFR2 (fibroblast growth factor receptor 2) gene as a locus associated with a small, but highly significant, increase in the risk of developing breast cancer...
  94. doi FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations
    Leon Raskin
    Department of of Internal Medicine, University of Michigan Medical School and School of Public Health, Ann Arbor, MI 48109, USA
    Cancer Epidemiol Biomarkers Prev 17:1060-5. 2008
    Genetic variation in FGFR2 is a newly described risk factor for breast cancer...
  95. pmc Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer
    Carmen Behrens
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:6014-22. 2008
    ....
  96. pmc Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma
    Michael G Gartside
    Division of Cancer and Cell Biology, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Mol Cancer Res 7:41-54. 2009
    We report that 10% of melanoma tumors and cell lines harbor mutations in the fibroblast growth factor receptor 2 (FGFR2) gene...
  97. pmc FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation
    Miriam S Udler
    Department of Public Health and Primary Care, University of Cambridge, UK
    Hum Mol Genet 18:1692-703. 2009
    Genome-wide association studies have identified FGFR2 as a breast cancer (BC) susceptibility gene in populations of European and Asian descent, but a causative variant has not yet been conclusively identified...
  98. pmc ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing
    Claude C Warzecha
    Department of Medicine, Renal Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell 33:591-601. 2009
    Cell-type-specific expression of epithelial and mesenchymal isoforms of Fibroblast Growth Factor Receptor 2 (FGFR2) is achieved through tight regulation of mutually exclusive exons IIIb and IIIc, respectively...
  99. doi Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma
    Chunyu Zhang
    Department of Surgery, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Clin Cancer Res 15:4017-27. 2009
    ..The aim of the present study was to investigate the specific role of TF in the esophageal cancer microenvironment...
  100. pmc Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia
    Uljana A Boyarskikh
    Pharmacogenomics Group, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
    Eur J Hum Genet 17:1688-91. 2009
    Polymorphisms within intron 2 of the FGFR2 gene have been associated with increased risk of breast cancer (BC) in European and Asian populations...
  101. doi FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan
    Takakazu Kawase
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Int J Cancer 125:1946-52. 2009
    ..2 genome-wide association studies demonstrated that single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2 (FGFR2) gene at intron 2 are significantly associated with the risk of female breast cancer...

Research Grants66

  1. Rashmi Bansal; Fiscal Year: 2016
    ....
  2. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..Pilot data suggest that Fgf receptor 2 (Fgfr2) during embryogenesis increases the number of "intermediate" progenitors in the SVZ, which in turn is associated ..
  3. MARJA MARIE HURLEY; Fiscal Year: 2016
    ..abstract_text> ..
  4. FIBROBLAST GROWTH FACTOR RECEPTORS IN CRANIOSYNOSTOSIS
    ETHYLIN JABS; Fiscal Year: 1999
    ..Mutational analysis of candidate genes in this region revealed mutations in the Fibroblast Growth Factor Receptor 2 gene (FGFR2) in all four of these conditions...
  5. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
    ..address the function of FGF signaling in the adult cerebrum, we conditionally deleted floxed alleles of Fgfr1 and Fgfr2 in an Fgfr3 null background...
  6. Jacob V P Eswarakumar; Fiscal Year: 2014
    ..Dominant gain-of-function mutations in the fibroblast growth factor receptor 2 (FGFR2) account for the majority of the human craniosynostosis syndromes including Crouzon, ..
  7. PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2012
    ..of cases of coronal craniosynostosis and Apert, Crouzon and Pfeiffer syndromes and micro-CT and micro-MR of two Fgfr2 mouse models for these syndromes...
  8. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
    ..10 transgenic mice after administration of OVA peptide. ..
  9. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert E Friesel; Fiscal Year: 2011
    ..Activating mutations in human FGFR1, FGFR2, and FGFRS are associated with skeletal dysplasias including craniosynostosis and dwarfing syndromes...
  10. Moosa Mohammadi; Fiscal Year: 2016
    ..Since substrate recruitment and phosphorylation by RTKs is a general event in RTK signaling, the mechanistic insights gained under Aim IV will also be directly applicable to the entire RTK superfamily. ..
  11. John Y L Chiang; Fiscal Year: 2016
    ..The long-term objectives of this research are to elucidate the molecular mechanism of regulation of CYP7A1 and bile acid metabolism, and pathogenesis and treatment of metabolic diseases such as fatty liver disease, diabetes and obesity. ..
  12. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..We can also analyze tyrosine phosphorylation of the proteins and determine if they physically interact with each other in the embryo. ..
  13. Growth Factor Signaling in Intestinal Development
    Steven Cohn; Fiscal Year: 2009
    ..The operant FGFR3 signaling pathways in intestinal epithelial cell lines, especially those impinging on TCF-4, will be investigated using a combination of biochemical and molecular approaches. ..
  14. ENDOTHELIAL CELL SENESCENCE GENES
    Thomas Maciag; Fiscal Year: 2000
    ..These studies should yield a better understanding of FGF-1 and precursor IL-1alpha signaling in HUVEC populations and firmly establish precursor IL-1alpha as a modifier of HUVEC senescence. ..
  15. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2009
    ..Drugs targeting to nuclear receptor and signaling pathways, and miRNA antagomirs may be developed for treating metabolic liver diseases. ..
  16. John Y L Chiang; Fiscal Year: 2016
    ..Drugs targeting to nuclear receptor and signaling pathways, and miRNA antagomirs may be developed for treating metabolic liver diseases. ..
  17. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    ..We will also study the role of adult stem cells in teeth, which may help to lay the groundwork for efforts to build new teeth. ..
  18. David M Ornitz; Fiscal Year: 2016
    ....
  19. Heparan sulfate proteoglycans in aging and development
    GREGORY COLE; Fiscal Year: 2009
    ..We predict that these proposed studies will provide important new insight into the function of agrin in the developing and aging nervous system. ..
  20. Michael J Econs; Fiscal Year: 2014
    ....
  21. Lumicrine regulation of epididymal function
    Barry T Hinton; Fiscal Year: 2010
    ..This proposal is part of a long term goal to understand the mechanisms by which the epididymis maintains an optimal luminal microenvironment for sperm maturation and survival, and therefore male fertility. ..
  22. Kenneth E White; Fiscal Year: 2016
    ..We expect our studies will provide novel, translational insight into rare, and common syndromes of altered FGF23 expression such as CKD-MBD, and into the basic biology of phosphate metabolism. ..
  23. CARLTON MATTHEW BATES; Fiscal Year: 2016
    ..Furthermore, conditional deletion of Fgfr1 and Fgfr2 in the metanephric mesenchyme (MM) with a Pax3cre line led to renal dysgenesis...
  24. Amin S Ghabrial; Fiscal Year: 2016
    ..3. To test the hypothesis that Polychaetoid and Too Many Leaders are downstream effectors of Notch signaling during tip cell competition. ..
  25. FGF Receptor in Myelin Function and Disease
    Rashmi Bansal; Fiscal Year: 2012
    ..Clarification of the role of FGF signaling in these processes can be expected to contribute to an informed clinical intervention to encourage remyelination and/or discourage demyelination. ..
  26. Studies of the Roles of Twist1 and E12 in Tooth Morphogenesis
    Yongbo Lu; Fiscal Year: 2012
    ..laboratory have shown that Twist1, together with its heterodimeric binding partner, E12, regulates FGF receptor 2 (Fgfr2) and Fgf10 promoter activities...
  27. PRODUCTION OF ALTERNATIVE FGF RECEPTOR FORMS IN TUMORS
    Gilbert J Cote; Fiscal Year: 2010
    ..A better understanding of this process may shed light on the transformation of astrocytes and provide new targets for suppressing their malignant growth. ..
  28. High throughput assays for modulators of splicing switches during the EMT
    RUSS PAUL CARSTENS; Fiscal Year: 2011
    ..A change in fibroblast growth factor receptor 2 (FGFR2) splicing occurs during the EMT and using an innovative luciferase-based splicing reporter ..
  29. FRS2-mediated Signals in Prostatic Tumorigenesis and Development
    Fen Wang; Fiscal Year: 2013
    ..linking the FGFR kinases to downstream signaling targets, which is differentially phosphorylated by the FGFR1 and FGFR2 kinases in prostate epithelial cells...
  30. NIAMS: CORT
    Thomas O Carpenter; Fiscal Year: 2010
    ..Most importantly the CORT will provide a successful working model of translational research for Yale and the wider biomedical academic community. ..
  31. Jean M Hebert; Fiscal Year: 2016
    ..In Aim 3, we determine whether and how Foxg1 participates in regulating Cdkn1a transcription in early telencephalic cells in vivo and whether Foxg1, Smad4, and Cdkn1a genetically interact. ..
  32. Developing Neuroendocrine Brain, Androgen, and Fibroblast Growth Factor Signaling
    WILSON CHUNG; Fiscal Year: 2010
    ..Therefore, novel insights in how FGF expression is regulated by testosterone may help us better understand the mechanisms involved in the onset of Kallmann syndrome. ..
  33. David M Ornitz; Fiscal Year: 2015
    ....
  34. WNTs, FGFs, and BMPs Induce and Maintain the Telencephalon
    Jean M Hebert; Fiscal Year: 2013
    ....
  35. Alternative splicing and epithelial-mesenchymal plasticity in prostate tumors
    MARIANO A GARCIABLANCO; Fiscal Year: 2013
    In epithelial cells alternative splicing of fibroblast growth factor receptor-2 (FGFR2) transcripts leads to the expression of the FGFR2(IIIb) isoform, whereas in mesenchymal cells the same process results in the synthesis of FGFR2(IIIc)..
  36. The role of FGF8 during cardiovascular development
    Anne M Moon; Fiscal Year: 2013
    ..abstract_text> ..
  37. Developing Neuroendocrine Brain, Androgen, and Fibroblast Growth Factor Signaling
    WILSON CHUNG; Fiscal Year: 2013
    ..The department of Biological Sciences has provided research facilities and guaranteed start-up funding. Furthermore, Dr. Chung is allowed to spend 75% of his time in order to establish his research program. ..
  38. STROMAL INFLUENCES ON BREAST CANCER PROGRESSION
    SANDRA MCLESKEY; Fiscal Year: 1999
    ..Transcription of such genes might be an important downstream event of FGFR stimulation and the protein products of such genes might be important in determining the phenotype of the tumor. ..
  39. TRANSCRIPTIONAL REGULATION BY FIBROBLAST GROWTH FACTOR
    Dwight Towler; Fiscal Year: 2001
    ..We propose to identify protein-DNA interactions and kinase cascades conferring FGFR1/FGFR2-regulated gene expression in osteoblasts, using osteocalcin (OC) and interstitial collagenase (MMP) FGF response ..
  40. CELLULAR COMMUNICATION IN MORPHOGENESIS
    Mark Krasnow; Fiscal Year: 2003
    ..Mutant clones that fail to attract are presumably unable to respond to hypoxia. A variation of the well established FLP/FRT system that allows examination of clones in living larvae is suggested for this purpose. ..
  41. FIBROBLAST GROWTH FACTOR RECEPTOR IN EARLY DEVELOPMENT
    Thomas Musci; Fiscal Year: 1992
    ..Understanding the early molecular events that direct differentiation pathways and control embryonic development is essential to the full understanding of the pathogenesis of these conditions...
  42. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 2001
    ..The analysis of these transgenic mice is anticipated to elucidate the role of these heparin binding growth factors in cardiac and skeletal muscle development. ..
  43. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 1993
    ..The analysis of these transgenic mice is anticipated to elucidate the role of these heparin binding growth factors in cardiac and skeletal muscle development...
  44. REGULATION OF FGF RECEPTOR SPLICING IN PROSTATE CANCER
    Russ Carstens; Fiscal Year: 2007
    ..Maintenance of this pathway requires mutually exclusive splicing of fibroblast growth factor receptor 2 (FGFR2) exons IIIb and IIIc to yield FGFR2-IIIb in epithelial cells and FGFR2-IIIc in mesenchymal (..
  45. FGF receptor signaling specificity in C.elegans
    MICHAEL KOELLE; Fiscal Year: 2007
    ..In this way, we will gain a clearer understanding of how specific responses are elicited by the activation of FGF receptors. ..
  46. Monoclonal Antibody to FGF Receptor 2 for Treatment of Gastric and Other Cancers
    K Jin Kim; Fiscal Year: 2009
    ..is to characterize monoclonal antibodies (mAbs) that bind and block the Fibroblast Growth Factor (FGF) Receptor 2 (FGFR2) for potential use in cancer therapy...
  47. A Novel Mitigation Agent for Gastrointestinal Syndrome of Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2009
    ..The results of these pre-clinical studies will provide the basis for eventual approval through the animal rule. A preliminary drug development plan has already been discussed with the FDA. ..
  48. ANGIOTENSIN REGULATION OF GENE EXPRESSION
    MICHAL STACHOWIAK; Fiscal Year: 2000
    ....
  49. Potential of a dominant-negative FGF mutant as a therapeutic in cancer
    Yoshikazu Takada; Fiscal Year: 2012
    ....
  50. Wei Hsu; Fiscal Year: 2016
    ....
  51. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..in numerous human craniosynostosis syndromes, with the majority of these syndromes implicating FGF receptors 2 (FGFR2). However, the precise role of TGF-beta1 and FGF-2 in cranial suture development has not been explained...
  52. FGF RECEPTOR SIGNALING IN BONE DEVELOPMENT
    Joseph Schlessinger; Fiscal Year: 2009
    ..Gene inactivation experiments in mice have shown that FGFR2 and FGFR3 play an important role in bone development...
  53. FGFR2 IN SKELETOGENESIS--MUTATIONAL ANALYSIS IN MICE
    HYUN DUCK NAH CEDERQUIST; Fiscal Year: 2002
    ..Recent genetic studies have linked various activating mutations in the fibroblast growth factor receptor 2 (FGFR2) gene to a subset of craniosynostosis syndromes, which have in common craniofacial skeletal ..
  54. Role of endocytosis by the neural crest in cardio-craniofacial development
    ANNA LUISE KEYTE; Fiscal Year: 2013
    ....
  55. Role of receptor tyrosine kinase signaling in branching morphogenesis
    PENGFEI PAUL LU; Fiscal Year: 2010
    ..Thus, Specific Aim 1 is to analyze the role of FGFR2 in the mammary epithelium during postnatal branching morphogenesis...
  56. Douglas G Burrin; Fiscal Year: 2015
    ..These studies in premature pigs are highly translational and will lead to new clinical practices in nutritional support and prevention of liver disease in infants. ..
  57. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
    ..This proposal will investigate the role of dietary inorganic phosphate in cancer initiation, promotion and progression. ..
  58. Marc R Freeman; Fiscal Year: 2015
    ..Our work will provide fundamental knowledge about how astrocytes develop and regulate their growth in the brain, and is expected to provide critical insights into how defects in astrocyte growth or function cause disease. ..
  59. FGF in sensory system development
    OLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010
    ..Moreover, a better understanding of the molecular pathways regulating normal development will be critical for rational strategies for hair cell replacement and regeneration in adult onset deafness. ..
  60. EMT, Extravasation and metastasis by N-Cadherin signaling
    Rachel B Hazan; Fiscal Year: 2013
    ..We will rule out the role of N-cadherin adhesion in this process. We believe these studies will broaden our understanding of mechanisms that regulate breast cancer metastasis and will provide insights into therapeutic application. ..
  61. Zebrafish Jaw Morphogenesis: Understanding Development Beyond the Embryo
    CRAIG ALBERTSON; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This proposal seeks to understand post-embryonic craniofacial development in an important model system - the zebrafish - by combining experimental embryology with statistical shape analyses. ..
  62. Dermatan sulfate and its role in tissue repair
    Katherine Radek; Fiscal Year: 2009
    ..Finding a dependence for DS by the essential FGFR2-IIIB ligands would predict that a disorder of DS synthesis or degradation would disrupt normal wound repair...
  63. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ..FGFR1 and FGFR2, negatively regulate growth of the bones and fibrous tissues, respectively...
  64. Defective nuclear FGFR1 signaling - a new model for PD
    MICHAL STACHOWIAK; Fiscal Year: 2003
    ..abstract_text> ..
  65. REGULATION OF FGF ACTIVITY BY FGF RECEPTOR SIGNALING
    Pamela Maher; Fiscal Year: 2000
    ....
  66. Oligodendrocyte Differentiation and Myelin Biogenesis
    Rashmi Bansal; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..