FGF13

Summary

Gene Symbol: FGF13
Description: fibroblast growth factor 13
Alias: FGF-13, FGF2, FHF-2, FHF2, fibroblast growth factor 13, fibroblast growth factor homologous factor 2
Species: human

Top Publications

  1. ncbi Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development
    I Munoz-Sanjuan
    Department of Molecular Biology and Genetics, Department of Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Development 126:409-21. 1999
  2. ncbi Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing
    I Munoz-Sanjuan
    Department of Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 275:2589-97. 2000
  3. pmc Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase
    Jon Schoorlemmer
    Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
    J Biol Chem 277:49111-9. 2002
  4. ncbi Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons
    Ellen K Wittmack
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:6765-75. 2004
  5. ncbi Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
    I Ding
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892-1002, USA
    Acta Oncol 36:337-40. 1997
  6. ncbi Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows
    C Pfarrer
    Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University, D 35392 Giessen, Germany
    Placenta 27:758-70. 2006
  7. ncbi Evaluation of the transfection property of a peptide ligand for the fibroblast growth factor receptor as part of PEGylated polyethylenimine polyplex
    Gururaj A Rao
    Department of Pharmaceutics, University of Florida, Gainesville, U S A
    J Drug Target 16:79-89. 2008
  8. pmc Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation
    Jing Zheng
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Perinatal Research Laboratories, PAB1 Meriter Hospital, Madison, WI 53715, USA
    Biol Reprod 78:143-50. 2008
  9. pmc Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways
    K Wang
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, WI 53715, USA
    Placenta 30:1045-51. 2009
  10. ncbi FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium
    Giannoula Soufla
    Department of Virology, Medical School, University of Crete, PO Box 1527, Heraklion 71003, Crete, Greece
    Cancer Lett 259:146-55. 2008

Research Grants

  1. Antidepressants and Fibroblast Growth Factor
    Italo Mocchetti; Fiscal Year: 2006
  2. Rashmi Bansal; Fiscal Year: 2016
  3. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2012
  4. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
  5. MARJA MARIE HURLEY; Fiscal Year: 2016
  6. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2010
  7. William L Murphy; Fiscal Year: 2016
  8. Injury and Recovery in Developing Brain
    Flora M Vaccarino; Fiscal Year: 2013
  9. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
  10. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2013

Detail Information

Publications260 found, 100 shown here

  1. ncbi Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development
    I Munoz-Sanjuan
    Department of Molecular Biology and Genetics, Department of Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Development 126:409-21. 1999
    ..Finally, we show that a secreted version of cFHF-2 activates the expression of HoxD13, HoxD11, Fgf-4 and BMP-2 ectopically, consistent with cFHF-2 playing a role in anterior-posterior patterning of the limb...
  2. ncbi Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing
    I Munoz-Sanjuan
    Department of Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 275:2589-97. 2000
    ....
  3. pmc Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase
    Jon Schoorlemmer
    Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
    J Biol Chem 277:49111-9. 2002
    ..Binding of p38delta to IB2 is mediated by the carboxyl-terminal half of the scaffold (IB2(Delta1-436)). FHF2 also binds weakly to IB2(Delta1-436) and can thereby increase p38delta interaction with IB2(Delta1-436)...
  4. ncbi Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons
    Ellen K Wittmack
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:6765-75. 2004
    ..b>FHF2 is abundantly expressed in the hippocampus and DRG neurons and colocalizes with Na(v)1...
  5. ncbi Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
    I Ding
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892-1002, USA
    Acta Oncol 36:337-40. 1997
    ..FGF(1/2) dose was 3 microg per i.v. injection given 24 and 4 hrs before the first radiation dose. FGF2 treated mice had a significant survival advantage over saline-treated mice with a DMF of 1.22 +/- 0.07 (p < 0...
  6. ncbi Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows
    C Pfarrer
    Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University, D 35392 Giessen, Germany
    Placenta 27:758-70. 2006
    ..b>FGF2 signals dominated in maternal vascular endothelia (VE), immature TGC, and MTC, whereas staining in other cell types ..
  7. ncbi Evaluation of the transfection property of a peptide ligand for the fibroblast growth factor receptor as part of PEGylated polyethylenimine polyplex
    Gururaj A Rao
    Department of Pharmaceutics, University of Florida, Gainesville, U S A
    J Drug Target 16:79-89. 2008
    ..The 7-mer peptide (MQLPLAT), targeted toward the fibroblast growth factor 2 (FGF2) receptor, was recently identified using a phage-display library method as possessing a high degree of specificity ..
  8. pmc Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation
    Jing Zheng
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Perinatal Research Laboratories, PAB1 Meriter Hospital, Madison, WI 53715, USA
    Biol Reprod 78:143-50. 2008
    Fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) are two key regulators of placental angiogenesis...
  9. pmc Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways
    K Wang
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, WI 53715, USA
    Placenta 30:1045-51. 2009
    ..In this study, we examined if hypoxia affected fibroblast growth factor-2 (FGF2)- and vascular endothelial growth factor (VEGF)-stimulated cell proliferation via the mitogen-activated protein ..
  10. ncbi FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium
    Giannoula Soufla
    Department of Virology, Medical School, University of Crete, PO Box 1527, Heraklion 71003, Crete, Greece
    Cancer Lett 259:146-55. 2008
    ..Fibroblast growth factor-2 (FGF2) is also mitogenic for various cell types and is associated with regulation of tumor angiogenesis and metastasis...
  11. ncbi Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter
    Regina C Armstrong
    Department of Anatomy, Physiology, and Genetics at the Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Neurosci 22:8574-85. 2002
    This study takes advantage of fibroblast growth factor 2 (FGF2) knock-out mice to determine the contribution of FGF2 to the regeneration of oligodendrocytes in the adult CNS...
  12. ncbi FGFs-1 and -2, and TGF beta 1 as inductive signals modulating in vitro odontoblast differentiation
    F J Unda
    Departamento de Biologia Celular y Ciencias Morfologicas Facultad de Medicina y Odontologia, Universidad Pais Vasco Euskal Herriko Unibertsitatea, Leioa 48940, Vizcaya, Spain
    Adv Dent Res 15:34-7. 2001
    We have studied the expression of FGF1 and FGF2 during mouse odontogenesis by immunohistochemistry. FGF1 was detected in differentiated odontoblasts and at the secretory pole of ameloblasts...
  13. pmc Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells
    Kai Wang
    Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 79:704-10. 2008
    A critical process for vascular endothelial growth factor (VEGF)- and fibroblast growth factor 2 (FGF2)-regulated cellular function is reversible protein phosphorylation, which is tightly controlled by a balance of protein kinases and ..
  14. doi Fibroblast growth factor-2 mRNA expression in the brainstem and spinal cord of normal and chronic spinally transected urodeles
    Marie Moftah
    INSERM U 862, Neurocentre Magendie, Pathophysiology of Spinal Networks, Bordeaux, France
    J Neurosci Res 86:3348-58. 2008
    ..the molecular basis of spinal cord regeneration in urodeles, but it is believed that fibroblast growth factor-2 (FGF2) may play an important role by inducing proliferation of neural progenitor cells...
  15. ncbi Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging
    Keith A Horvath
    Division of Cardiothoracic Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Ann Thorac Surg 74:481-6; discussion 487. 2002
    ..of this study was to investigate whether an experimental link could be made between the ability of a novel fibroblast growth factor 2 (FGF2) gene formulation to promote neovascularization, and its ability to restore myocardial function.
  16. ncbi Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway
    Eric Sulpice
    Institut des Vaisseaux et du Sang IVS, Centre de Recherche de l association Claude Bernard, Hopital Lariboisiere, 8 rue Guy Patin, 75475 Paris Cedex 10, France
    Blood 100:3087-94. 2002
    ..the effects of PF-4 on the intracellular signal transduction induced by basic fibroblast growth factor (FGF2)...
  17. ncbi In vivo involvement of heparan sulfate proteoglycan in the bioavailability, internalization, and catabolism of exogenous basic fibroblast growth factor
    S Colin
    Service de Biochimie et Génétique Moléculaire, CEA Saclay, F 91191 Gif sur Yvette Cedex, France
    Mol Pharmacol 55:74-82. 1999
    The in vivo bioavailability of exogenous fibroblast growth factor 2 (FGF2) was studied after i.v. injection of uniformly 14C-labeled FGF2 into young rats. 14C-FGF2 was rapidly accumulated in almost all solid organs within 5 min...
  18. ncbi Distribution of cells expressing Jun and Fos proteins and synthesizing DNA in the adrenal cortex of hypophysectomized rats: regulation by ACTH and FGF2
    Thompson Eusebio Pavan Torres
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508 900, SP, Brazil
    Cell Tissue Res 329:443-55. 2007
    ..The effects of adrenocorticotropic hormone (ACTH) and fibroblast growth factor 2 (FGF2) on Fos and Jun protein expression were investigated, and DNA synthesis was assessed by using bromodeoxyuridine (..
  19. ncbi Uptake of adenoviral vectors via fibroblast growth factor receptors involves intracellular pathways that differ from the targeting ligand
    D K Hoganson
    Selective Genetics, Inc, 11035 Roselle Street, San Diego, California 92121, USA
    Mol Ther 3:105-12. 2001
    ..delivery of adenoviral gene therapy vectors has been achieved by introducing basic fibroblast growth factor (FGF2) onto viral capsids...
  20. ncbi FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cells
    C Martin
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C Ramón y Cajal 7, 47005 Valladolid, Spain
    Dev Biol 297:402-16. 2006
    ..Fibroblast growth factor 2 (FGF2) has been involved in the regulation of these processes, and although it has been suggested that they work in an ..
  21. pmc Focal adhesion kinase (FAK) expression and activation during lens development
    Maria I Kokkinos
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia
    Mol Vis 13:418-30. 2007
    ..of FAK expression and tyrosine phosphorylation (Y397) in the developing lens and investigated its regulation by FGF2. We also examined FAK expression and activation during disrupted fiber differentiation in mice expressing a ..
  22. pmc Action of fibroblast growth factor-2 on the intervertebral disc
    Xin Li
    Department of Biochemistry, Rush University Medical Center, Cohn Research BD 516, 1735 W, Harrison, Chicago, IL 60612, USA
    Arthritis Res Ther 10:R48. 2008
    Fibroblast growth factor 2 (FGF2) is a growth factor that is immediately released after cartilage injury and plays a pivotal role in cartilage homeostasis...
  23. ncbi Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element
    M Bidder
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 39:8917-28. 2000
    ..via protein-DNA interactions at the Ets cognate, and minimally two mechanisms convey MMP1 promoter upregulation by FGF2: (a) transcriptional activation via Fra1/c-Jun containing DNA-protein interactions at the AP1 cognate and (b) ..
  24. ncbi Role of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells
    S A Mousa
    DuPont Pharmaceuticals Company, Wilmington, Delaware 19880 0400, USA
    J Cell Biochem 74:135-43. 1999
    ..of soluble vitronectin, or fibrinogen to RPE cell cultures resulted in a small to moderate increase in VEGF and FGF2 in the media, while each of these growth factors was dramatically increased after addition of thrombospondin 1 (..
  25. doi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
    Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis...
  26. pmc Endogenous FGF-2 is critically important in PTH anabolic effects on bone
    Maria Giovanna Sabbieti
    Department of Comparative Morphology and Biochemistry, University of Camerino, Camerino MC, Italy
    J Cell Physiol 219:143-51. 2009
    ..and fibroblast growth factor-2 (FGF-2) expression in osteoblasts and the anabolic response to PTH is reduced in Fgf2-/- mice...
  27. pmc Establishment of a functional ovine fetoplacental artery endothelial cell line with a prolonged life span
    Yang Song
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 76:29-35. 2007
    ..These OFPAE cells produce nitric oxide (NO), proliferate, and migrate in response to fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF)...
  28. pmc Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
    D L Miller
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 20:2260-8. 2000
    Fibroblast growth factor 1 (FGF1) and FGF2, the prototypic members of the FGF family of growth factors, have been implicated in a variety of physiological and pathological processes...
  29. ncbi Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1
    F J Unda
    Departamento de Biologia Celular y Ciencias Morfologicas, Facultad de Medicina y Odontologia, Universidad Pais Vasco Euskal Herriko Unibertsitatea, Leioa, Vizcaya, Spain
    Dev Dyn 218:480-9. 2000
    ..of 17-day-old mouse embryos were cultured in the presence of combinations of the following growth factors: FGF1, FGF2, and TGFbeta1...
  30. ncbi Site-specific interactions of neurotrophin-3 and fibroblast growth factor (FGF2) in the embryonic development of the mouse cochlear nucleus
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06030, USA
    J Neurobiol 66:897-915. 2006
    Neurotrophins and FGF2 contribute to formation of the cochlea, but their roles in cochlear nucleus development are unknown...
  31. ncbi The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2
    Stacey L House
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    Am J Physiol Heart Circ Physiol 293:H354-65. 2007
    ..Our laboratory has previously shown that cardiac-specific overexpression of fibroblast growth factor-2 (FGF2) results in increased recovery of contractile function and decreased infarct size following ischemia-reperfusion ..
  32. doi Relative role of upstream regulators of Akt, ERK and CREB in NCAM- and FGF2-mediated signalling
    Dorte Kornerup Ditlevsen
    Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Panum Institute, Building 6 2, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Neurochem Int 53:137-47. 2008
    ..For comparison, we also evaluated the role of upstream signalling cascades on fibroblast growth factor 2 (FGF2)-mediated phosphorylation of ERK, Akt, and CREB and found that FGF2 required the activity of both FGFR and Src-..
  33. doi Analysis of segregation distortion and association of the bovine FGF2 with fertilization rate and early embryonic survival
    X Wang
    College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi 712100, China
    Anim Genet 40:722-8. 2009
    Fibroblast growth factor 2 (FGF2) plays an important role in fertility and early embryo development...
  34. doi FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner
    Jacqueline Ameri
    Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Stem Cells 28:45-56. 2010
    ..Studies in lower vertebrates have demonstrated that FGF2 primarily patterns the ventral foregut endoderm into liver and lung, whereas FGF4 exhibits broad anterior-posterior ..
  35. pmc Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-γ
    Byung Jae Lee
    Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Exp Mol Med 43:169-78. 2011
    ..Fibroblast growth factor 2 (FGF2), which is the downstream mediator of TGF-β, is important in wound healing...
  36. ncbi Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury
    Takeshi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 10:462-7. 2004
    To examine the role of fibroblast growth factor 2 (FGF2) in regulating lens cell proliferation and epithelial-mesenchymal transition (EMT) in response to injury.
  37. ncbi Fibroblast growth factor 2: from laboratory evidence to clinical application
    Chu Huang Chen
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Vasc Pharmacol 2:33-43. 2004
    Fibroblast growth factor 2 (FGF2) is expressed ubiquitously in mesodermal and neuroectodermal cells...
  38. ncbi Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage
    Andy J Fischer
    Department of Neuroscience, Ohio State University, Columbus 43210, USA
    Mol Vis 10:973-86. 2004
    ..The purpose of this study was to assay whether growth factors influence the expression of filamentous proteins in Muller glia in the intact retinas of postnatal chickens...
  39. pmc Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene
    Kesi Chen
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    BMC Neurosci 9:94. 2008
    The Fgf2 gene is expressed in the brain neuroepithelium during embryonic development and in astroglial cells throughout life...
  40. doi Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling
    Su Jin Park
    Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, Seoul, Republic of Korea
    Bone 45:994-1003. 2009
    Fibroblast growth factor 2 (FGF2), the potent bone anabolic agent, regulates the bone development, as well as the growth, remodeling and healing of the fracture...
  41. ncbi Cell-mediated delivery of fibroblast growth factor-2 and vascular endothelial growth factor onto the chick chorioallantoic membrane: endothelial fenestration and angiogenesis
    D Ribatti
    Department of Human Anatomy, University of Bari Medical School, Bari, Italy
    J Vasc Res 38:389-97. 2001
    Fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) exert their angiogenic activity by interacting with endothelial cells in a distinct manner...
  42. pmc The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling
    Siyun Liao
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 42:106-20. 2007
    Our laboratory showed that overexpression of fibroblast growth factor-2 (FGF2) protected the heart against ischemia-reperfusion injury...
  43. pmc FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha
    Caroline Conte
    Institut National de la Sante et de la Recherche Medicale INSERM, U858, Toulouse, France
    PLoS ONE 3:e3078. 2008
    Fibroblast growth factor 2 (FGF2) is a major angiogenic factor involved in angiogenesis and arteriogenesis, however the regulation of its expression during these processes is poorly documented...
  44. pmc The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury
    Siyun Liao
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 48:1245-54. 2010
    Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low [LMW] and high molecular weight [HMW]), which are localized to different cellular compartments, indicating unique biological activity...
  45. doi Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist
    Patrizia Alessi
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy
    Eur Cytokine Netw 20:225-34. 2009
    ..One proposed mechanism of tumor escape from anti-VEGF therapy is the up-regulation of fibroblast growth factor-2 (FGF2). FGF2 is a pleiotropic, angiogenesis inducer belonging to the family of the heparin-binding FGF growth factors...
  46. pmc ATP differentially upregulates fibroblast growth factor 2 and transforming growth factor α in neonatal and adult mice: effect on neuroproliferation
    C Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 177:335-46. 2011
    ..hypotheses that ATP induces the synthesis and secretion of two neurotrophic factors, fibroblast growth factor 2 (FGF2) and transforming growth factor alpha (TGFα), and that these neurotrophic factors have a role in inducing ..
  47. ncbi Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2
    Irina Kiprianova
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
    Exp Neurol 189:252-60. 2004
    ..We have used mice with a null mutation of the fgf2 gene to explore the relevance of endogenous FGF-2 in brain ischemia...
  48. ncbi Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    J Neurosci Res 84:980-92. 2006
    ..spinal cord treated with intrathecal infusion of epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF2) into the lumbar spinal cord region of normal and symptomatic transgenic (Tg) mice with a mutant human Cu/Zn ..
  49. pmc Extracellular matrix-mediated differentiation of periodontal progenitor cells
    Smit J Dangaria
    Brodie Laboratory for Craniofacial Genetics, Departments of Oral Biology and Orthodontics, UIC College of Dentistry, The University of Illinois at Chicago, Chicago, IL 60565, USA
    Differentiation 78:79-90. 2009
    ..of diseased periodontal tissues, we have tested the effect of periodontal ECM signals, fibroblast growth factor 2 (FGF2), connective tissue growth factor (CTGF), and the cell adhesion peptide Arg-Gly-Asp (RGD) on the differentiation of ..
  50. ncbi Gene expression profile in fibroblast growth factor 2-transformed endothelial cells
    Patrizia Dell'Era
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, 25123 Brescia, Italy
    Oncogene 21:2433-40. 2002
    Fibroblast growth factor-2 (FGF2) exerts paracrine and autocrine functions on endothelial cells...
  51. ncbi In vivo analysis of oligodendrocyte lineage development in postnatal FGF2 null mice
    Joshua C Murtie
    Program in Molecular and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Glia 49:542-54. 2005
    Analysis of fibroblast growth factor 2 null (FGF2-/-) and wild-type (FGF2+/+) mice was used to interpret the potential in vivo role of endogenous FGF2 on oligodendrocyte lineage cell (OLC) responses during oligodendrogenesis and ..
  52. ncbi Fibroblast growth factor 2 is more dynamic than vascular endothelial growth factor A during the follicle-luteal transition in the cow
    R S Robinson
    Division of Animal Physiology, University of Nottingham, Loughborough, Leics LE12 5RD, United Kingdom
    Biol Reprod 77:28-36. 2007
    ..we examined the temporal changes in vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) during the follicular-luteal transition and CL ..
  53. pmc Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons
    Alessia Bachis
    Department of Neuroscience, Georgetown University Medical Center, EP04, New Research Building, 3970 Reservoir Road, NW, Washington, DC 20057, USA
    Neuropharmacology 55:1114-20. 2008
    ..Fibroblast growth factor 2 (FGF2) is a growth factor essential for the proper formation of synaptic connections in the cerebral cortex, maturation ..
  54. pmc Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6
    Jason R Spence
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Mol Vis 13:57-65. 2007
    ..To elucidate the early cellular events that take place during induction of retina regeneration in the embryonic chick, focusing on the relationship between fibroblast growth factor (FGF) signaling and the regulation of Pax6 and Mitf...
  55. ncbi FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase
    Riccardo Caldini
    Department of Experimental Pathology and Oncology, University of Florence, Italy
    J Cell Physiol 202:125-34. 2005
    ..We have analyzed whether poly(ADP-ribose) polymerase activity is involved in basic fibroblast growth factor (FGF2)-mediated upregulation of urokinase-type plasminogen activator (uPA) mRNA...
  56. pmc Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2
    S Ortega
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 95:5672-7. 1998
    Basic fibroblast growth factor (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary...
  57. ncbi Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault
    S Iseki
    Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Development 126:5611-20. 1999
    ..Subcutaneous insertion of FGF2-soaked beads onto the coronal suture on E15 resulted in up-regulation of osteopontin and Fgfr1 in the sutural ..
  58. ncbi Identification of FGF2-response element in the rat bone sialoprotein gene promoter
    Emi Shimizu-Sasaki
    Department of Endodontics, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    Connect Tissue Res 44:103-8. 2003
    ..Basic fibroblast growth factor (FGF2) is recognized as a potent mitogen for a variety of mesenchymal cells...
  59. ncbi Sequence analysis of the fibroblast growth factor 2 gene from the spontaneously hypertensive and hypertrophic heart rats
    Jeremy P Dwyer
    Department of Physiology, University of Melbourne, Victoria, Australia
    Clin Exp Hypertens 26:209-18. 2004
    ..This locus (Lvm1; left ventricular mass locus 1) contains the gene Fgf2 that codes for the potent cardiac growth factor, Fibroblast Growth Factor 2 (FGF2)...
  60. ncbi siRNA mediated knockdown of fibroblast growth factor receptors 1 or 3 inhibits FGF-induced anchorage-independent clonogenicity but does not affect MAPK activation
    Norman R Estes
    Biochemistry and Molecular Biology Department, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35255, USA
    Oncol Rep 15:1407-16. 2006
    ..of individual FGFRs, in anchorage-independent growth, we determined the effects of down-regulation of each FGFR on FGF2- and FGF4-mediated soft agar colony formation in these cells...
  61. ncbi Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3
    Maura Camozzi
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy
    J Biol Chem 281:22605-13. 2006
    ..PTX3 binds fibroblast growth factor-2 (FGF2), inhibiting its pro-angiogenic and pro-restenotic activity...
  62. ncbi Gene expression changes of inflammatory mediators in posterior laryngitis due to laryngopharyngeal reflux and evolution with PPI treatment: a preliminary study
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
    Laryngoscope 117:2050-6. 2007
    ..growth factor beta 1 (TGFbeta1), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF2), and tumor necrosis factor alpha (TNFalpha) -- in posterior larynx tissue would be increased in those with ..
  63. ncbi Functional evolutionary history of the mouse Fgf gene family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:18-27. 2008
    ..However, all Fgfs are evolutionarily related. We propose that an Fgf13-like gene is the ancestor of the iFgf subfamily and the most likely evolutionary ancestor of the entire Fgf family...
  64. pmc Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
    Clare L Parish
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 118:149-60. 2008
    ..Mouse VM neurospheres (VMNs) expanded with FGF2, differentiated with sonic hedgehog and FGF8, and transfected with Wnt5a (VMN-Wnt5a) generated 10-fold more DA ..
  65. pmc Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graft
    Tatsuya Yoshida
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Orthop Surg Res 4:31. 2009
    ..In the course of establishing such a model, we made a preliminary examination of the effect of muscle coverage or fibroblast growth factor 2 (FGF-2) administration radiographically...
  66. pmc IRES-based vector coexpressing FGF2 and Cyr61 provides synergistic and safe therapeutics of lower limb ischemia
    Audrey Rayssac
    INSERM, U858, Toulouse, France
    Mol Ther 17:2010-9. 2009
    ..entry site (IRES)-based bicistronic vector expressing two angiogenic molecules, fibroblast growth factor 2 (FGF2), and Cyr61...
  67. doi Regulation of angiogenesis-related prostaglandin f2alpha-induced genes in the bovine corpus luteum
    Yulia Zalman
    Department of Animal Sciences, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Biol Reprod 86:92. 2012
    ..We found that PG regulated angiogenesis-modulating factors in a luteal stage-dependent way. A robust increase in FGF2 expression (mRNA and protein) occurred in the PG-refractory Day 4 CL promoting CL survival and function...
  68. doi Fibroblast growth factor 2 inhibits up-regulation of bone morphogenic proteins and their receptors during osteoblastic differentiation of human mesenchymal stem cells
    Emmanuel Biver
    Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer, France
    Biochem Biophys Res Commun 427:737-42. 2012
    ..They exert their actions via BMP receptors (BMPR), including BMPR1A, BMPR1B and BMPR2. Fibroblast growth factor 2 (FGF2) is expressed by cells of the osteoblastic lineage, increases their proliferation and is secreted during the ..
  69. pmc Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis
    Giang D Nguyen
    Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 8:e64368. 2013
    ..The transition from Q111 pNSCs to fibroblast growth factor 2 (FGF2)-responsive dNSCs was marked by potentiation in the number of dNSCs and altered proliferative potential...
  70. doi Renal heparan sulfate proteoglycans modulate fibroblast growth factor 2 signaling in experimental chronic transplant dysfunction
    Kirankumar Katta
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Pathol 183:1571-84. 2013
    ..heparan sulfate proteoglycan perlecan was observed, along with massive accumulation of fibroblast growth factor 2 (FGF2)...
  71. doi Activation of the CXCL12/CXCR4 signaling axis may drive vascularization of the ovine placenta
    K E Quinn
    Department of Animal and Range Sciences, New Mexico State University, Las Cruces, NM 88003, USA
    Domest Anim Endocrinol 47:11-21. 2014
    ..Greater levels of fibroblast growth factor 2 (FGF2) mRNA was observed in CAR on day 20 of gestation than on day 30...
  72. doi Thyroid hormone induced angiogenesis through the integrin αvβ3/protein kinase D/histone deacetylase 5 signaling pathway
    Xin Liu
    Key Laboratory of Hormones and Development Ministry of Health, Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, 300070 Tianjin, China
    J Mol Endocrinol 52:245-54. 2014
    ..As a potent pro-angiogenic growth factor, basic fibroblast growth factor (bFGF (FGF2)) is a downstream target gene of HDAC5...
  73. pmc Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription
    Cynthia L Neben
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Hum Mol Genet 23:5659-71. 2014
    ..that cause BBDS reduce receptor levels at the plasma membrane and diminish responsiveness to extracellular FGF2. In this study, we find that these mutations, despite reducing canonical signaling, enhance nucleolar occupancy of ..
  74. pmc A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2
    Sonja Zacherl
    From the Heidelberg University Biochemistry Center BZH, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Biol Chem 290:3654-65. 2015
    Previous studies proposed a role for the Na/K-ATPase in unconventional secretion of fibroblast growth factor 2 (FGF2). This conclusion was based upon pharmacological inhibition of FGF2 secretion in the presence of ouabain...
  75. pmc Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs
    Isabel Ben-Batalla
    Department of Hematology and Oncology, BMT with Section of Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncotarget 6:6341-58. 2015
    ..factors active besides the VEGF axis including hepatocyte growth factor (HGF) and basic fibroblast growth factor (FGF2)...
  76. doi Synergistic effect of PDGF and FGF2 for cell proliferation and hair inductive activity in murine vibrissal dermal papilla in vitro
    Masahiro Kiso
    Department of Dermatology, The Jikei University School of Medicine, Japan
    J Dermatol Sci 79:110-8. 2015
    ..DPCs are promising cell sources for hair regeneration therapy for alopecia patients. However, once DPCs are put into conventional two-dimensional culture conditions, they quickly lose their capability to produce hair follicles...
  77. pmc Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the chronic renal insufficiency cohort study
    Jayanta Gupta
    Division of Biostatistics and Epidemiology, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas
    Wound Repair Regen 24:705-11. 2016
    ..with diabetes, rs11938826 and rs1960669, both intronic SNPs in the gene basic fibroblast growth factor-2 (FGF2), were significantly associated with LEA in covariate-adjusted analysis (OR: 2.83 (95% CI: 1.73, 4.62); p-value: 0...
  78. doi Novel harmful recessive haplotypes for reproductive traits in pigs
    J Häggman
    Department of Agricultural Sciences, University of Helsinki, Helsinki, Finland
    J Anim Breed Genet . 2016
    ..Three possible candidate genes were found in this chromosomal region: MAD2LI, FGF2 and ANXA5. Further analysis is needed to confirm the role of these genes on pig reproductive performance.
  79. pmc FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia
    Elie Traer
    Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon
    Cancer Res 76:6471-6482. 2016
    ..model of resistance whereby extrinsic microenvironmental proteins FLT3 ligand (FL) and fibroblast growth factor 2 (FGF2) protect FLT3-ITD+ MOLM14 cells from AC220, providing time for subsequent accumulation of ligand-independent ..
  80. ncbi Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2
    S Iseki
    Department of Human Anatomy, Oxford, UK
    Development 124:3375-84. 1997
    ..Fibroblast growth factor type 2 (FGF2) protein, which has a high affinity for the FGFR2 splice variant associated with craniosynostosis, is locally ..
  81. ncbi Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Dev Biol 208:166-88. 1999
    ..By separately blocking EGF and FGF2 signaling, we also show that EGF alone and FGF2 alone can independently elicit neural stem cell proliferation and ..
  82. ncbi FGF2 promotes skeletogenic differentiation of cranial neural crest cells
    S Sarkar
    Developmental Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Development 128:2143-52. 2001
    ..We now show that, in vitro, mesencephalic neural crest cells respond to exogenous FGF2 in a dose-dependent manner, with 0...
  83. ncbi Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF
    Guifu Wu
    Angiogenesis Research Center, Division of Cardiology, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 285:H2420-9. 2003
    ..86 +/- 1.03-fold) and IL-1beta (3.93 +/- 0.89-fold) and slightly increased by TNF-alpha but not by FGF2, IGF-1, or PDGFs...
  84. ncbi Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney
    Dylan L Steer
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0693, USA
    Dev Biol 272:310-27. 2004
    ..Disruption of endogenous HS sulfation with chlorate resulted in diminished FGF2 binding and proliferation, which markedly altered kidney area but did not have a statistically significant effect ..
  85. ncbi Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
    Amanda E Serls
    Department of Pathology, University of Colorado Health Sciences Center, The Children s Hospital, 1056 East 19th Avenue, Denver, CO 80218, USA
    Development 132:35-47. 2005
    ..of cardiac mesoderm, ventral foregut endoderm explants respond to exogenous fibroblast growth factor (FGF) 1 and FGF2 in a dose-dependent manner, with lower concentrations activating liver specific genes and higher concentrations ..
  86. ncbi Lysophosphatidic acid induces clonal generation of mouse neurospheres via proliferation of Sca-1- and AC133-positive neural progenitors
    Stanislav I Svetlov
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Stem Cells Dev 13:685-93. 2004
    ..produce neurospheres in serum-free medium containing epidermal growth factor (EGF) and fibroblast growth factor (FGF2)...
  87. ncbi Novel vascularization strategies
    M Simons
    Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    IDrugs 2:396-7. 1999
    ..Several early trials of angiogenic agents including VEGF165 and FGF2 were presented at this meeting...
  88. ncbi The nucleotide analog cidofovir suppresses basic fibroblast growth factor (FGF2) expression and signaling and induces apoptosis in FGF2-overexpressing endothelial cells
    Sandra Liekens
    Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
    Mol Pharmacol 71:695-703. 2007
    ..shown that cidofovir inhibits the development of vascular tumors induced by basic fibroblast growth factor (FGF2)-overexpressing endothelial cells (FGF2-T-MAE) in mice...
  89. ncbi Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis
    Marjorie Pick
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria 3800, Australia
    Stem Cells 25:2206-14. 2007
    ..4 (BMP4), vascular endothelial growth factor (VEGF), stem cell factor (SCF), and basic fibroblast growth factor (FGF2), singly and in combination, on the generation of hematopoietic cells from human embryonic stem cells (HESCs)...
  90. pmc Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries
    Dan Liao
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Biochem Biophys Res Commun 372:668-73. 2008
    ..muscle cell (SMC) proliferation of porcine carotid arteries in response to injury, basic fibroblast growth factor (FGF2), and FGF2 conjugated with cytotoxin saporin (SAP)...
  91. doi Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion
    Antje D Ebert
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Traffic 11:813-26. 2010
    Fibroblast growth factor 2 (FGF2) is a potent mitogen that is exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism...
  92. ncbi Fibroblast growth factor 2 regulates bone sialoprotein gene transcription in human breast cancer cells
    Zhengyang Li
    Department of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Oral Sci 52:125-32. 2010
    ..Fibroblast growth factor 2 (FGF2) is recognized as a potent mitogen for a variety of mesenchymal cells...
  93. doi Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal
    Jie Na
    School of Medicine, Tsinghua University, Beijing, China
    Stem Cell Res 5:157-69. 2010
    ..for more than 3months in the presence of ERK1/2 inhibitors in a chemically defined culture system containing FGF2 and activin A but no BMP4...
  94. pmc Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels
    Chaojian Wang
    Ion Channel Research Unit, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:24253-63. 2011
    ..This proline is conserved among all FHFs, and mutation of the homologous residue in FGF13 also leads to loss of interaction with a specific VGSC CT (Na(V)1...
  95. pmc Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levels
    Wen Tzu Lai
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Stem Cells 29:1102-11. 2011
    ..Previously, we reported that fibroblast growth factor 2 (Fgf2) reversibly inhibited multilineage differentiation of primary mouse MSCs and now identify a unique compliment of ..
  96. doi Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells
    Seong Moon Cheong
    Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Kyungbuk, 790 784, Republic of Korea
    Exp Cell Res 318:550-7. 2012
    ..we show that Dab2 is required for the TGFβ-induced gene expression of angiogenic factors such as VEGF and FGF2. Taken together, these results suggest that Dab2, which is expressed in cancer cells, is pivotal for endothelial ..
  97. doi HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity
    Amal Seffouh
    Institut de Biologie Structurale Jean Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique Commissariat à l Énergie Atomique et aux Énergies Alternatives Université Joseph Fourier, Grenoble, France
    FASEB J 27:2431-9. 2013
    ..fibroblast growth factor (FGF)-induced mitogenesis and found that the enzyme could differentially regulate FGF1 and FGF2 activities...
  98. pmc Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients
    Rajendra Gharbaran
    John Theurer Cancer Center, Hackensack University Medical Center, d, Jurist Research Building, 40 Prospect Avenue, Hackensack, NJ 07601, USA
    J Hematol Oncol 6:62. 2013
    ....
  99. pmc Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF
    William C Bowen
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e95487. 2014
    ..medium for mouse hepatocytes and demonstrate that in addition to EGFR ligands and HGF, the growth factors FGF1 and FGF2 are also important mitogenic factors for mouse hepatocytes. Smaller mitogenic response was also noticed for PDGF AB...
  100. doi Effects of BMP-2 and FGF2 on the osteogenesis of bone marrow-derived mesenchymal stem cells in hindlimb-unloaded rats
    Xiaodan Qian
    Institute of Cell and Development, College of Life Sciences, Zhejiang University, Zi Jin Gang Campus, Hangzhou, 310058, Zhejiang, People s Republic of China
    Cell Biochem Biophys 70:1127-36. 2014
    ..by 28-day of hindlimb unloading for male Sprague-Dawley rat, and performed intramuscular injection of BMP-2 and FGF2 at a given interval during hindlimb unloading. Then, the bone marrow (BM) was collected from hindlimb femur of rat...

Research Grants68

  1. Antidepressants and Fibroblast Growth Factor
    Italo Mocchetti; Fiscal Year: 2006
    ..by preliminary data showing that antidepressants increase the synthesis of basic fibroblast growth factor (FGF2), a neurotrophic factor that exerts neurotrophic activity on catecholaminergic neurons and promotes neurogenesis in ..
  2. Rashmi Bansal; Fiscal Year: 2016
    ..In Aim III we will over-express FGF1 or FGF2 postnatally in neurons of transgenic mice to test a potentially paradigm shifting hypothesis that FGF/FGFR ..
  3. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2012
    ..characterize a humanized monoclonal antibody (mAb) that binds and inhibits human Fibroblast Growth Factor 2 (FGF2;basic FGF) for potential use in cancer therapy...
  4. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..cortical morphogenesis will be compared amongst mice lacking Fgfr2 versus mice with a combined deletion of Fgfr1, Fgf2 and Fgf3...
  5. MARJA MARIE HURLEY; Fiscal Year: 2016
    ..Our studies support an important role for the nuclear isoforms of Fibroblast Growth Factor 2 (FGF2) in FGF23 production and biologic function...
  6. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2010
    ..proposed research is to characterize a monoclonal antibody (mAb) that binds and blocks Fibroblast Growth Factor 2 (FGF2) for potential use in cancer therapy...
  7. William L Murphy; Fiscal Year: 2016
    ..be used to regulate the effects of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF2) on endothelial cells in 2-dimensional and 3-dimensional culture environments...
  8. Injury and Recovery in Developing Brain
    Flora M Vaccarino; Fiscal Year: 2013
    ..The factors under investigation include Fibroblast growth factor 2 (FGF2), the Epidermal growth factor receptor (EGFR), TrkB and its ligand Brain derived neurotropic growth factor (BDNF), ..
  9. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
    ..Previous immunohistochemical analyses suggested that nuclear FGF2 and at least one receptor are up-regulated in astrocytes in response to damage (Eddleston and Mucke, 1993;Ridet et ..
  10. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..that in addition to its role in promoting osteoblast (OB) function and bone formation, fibroblast growth factor 2 (FGF2) is a negative regulator of mesenchymal stem cell differentiation into mature adipocytes (AD)...
  11. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..data) a significant decrease in the frontal cortical gene expression of somatostatin, fibroblast growth factor-2 (FGF2) and growth arrest and DNA-damage-inducible-beta (GADD45B), and an increase in gene expression of serum/..
  12. Gadiparthi N Rao; Fiscal Year: 2016
    ..Interestingly enough, blockade of either CREB or STAT3 inhibits VEGFC and FGF2-induced expression of DLL4 and cleaved NOTCH1 in HRMVECs...
  13. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ..The hypotheses are that certain FGFs released from bone matrix (FGF2), the suture cells, and the dura mater (other that FGF2 or 7) diffuse to the extracellular matrix of the developing ..
  14. Katia Del Rio-Tsonis; Fiscal Year: 2014
    ..following retinectomy, via the process of trans-differentiation if exposed to ectopic fibroblast growth factor 2 (FGF2)...
  15. Ningjun Li; Fiscal Year: 2014
    ..In preliminary studies, we found that the level of an important stem cell niche factor, fibroblast growth factor-2 (FGF2), the number of CD133 positive stem cells and their responses to high salt intake were significantly decreased in ..
  16. Dvelopment of multi-component peptide vehicles for in vivo neuronal gene therapy
    Ester J Kwon; Fiscal Year: 2010
    ..of NPCs through the delivery of therapeutic genes encoding mitogenic factors such as fibroblast growth factor 2 (FGF2) can cause increased recruitment to damaged areas in the brain...
  17. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    ..Studies performed in this funding period show that rPAI-123 inhibits fibroblast growth factor-2 (FGF2) signaling pathways and functions...
  18. Neurodevelopmental Basis of Anxiety and Depressive Behavior
    Sarah M Clinton; Fiscal Year: 2010
    ..will manipulate hippocampal development via administration of the neurotrophic factor Fibroblast Growth Factor-2 (FGF2) to determine whether it can reshape low novelty-seekers'neural emotional circuits and assuage the emergence ..
  19. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..IL-8 and IL-12), as well as deregulation of a number of genes that have been associated with dementia (GLS, SOD2, FGF2 and CHMP2B)...
  20. Generation of a Novel Therapeutic for Prostate Cancer Bone Metastasis
    DONALD EDWARD STAUNTON; Fiscal Year: 2010
    ..CT400P must maintain: 1) high affinity for FGFRs and lack of integrin binding, 2) efficient antagonism of FGF1 and FGF2- induced cell proliferation, and 3) efficient reversal of cancer cell chemoresistance...
  21. David M Ornitz; Fiscal Year: 2015
    ..Following myocardial infarction, hearts lacking Fgf2 show reduced fibroblast proliferation and collagen deposition, decreased endothelial proliferation and vascular ..
  22. Marco C Bottino; Fiscal Year: 2016
    ..types in a location specific manner, through the addition of calcium phosphate and fibroblast growth factor-2 (CaP/FGF2) and FGF2, will lead to alveolar and periodontal tissue regeneration in the appropriate locations...
  23. FGF-2 Autocrine Signaling in Lung Cancer
    Lynn E Heasley; Fiscal Year: 2012
    ..Importantly, we show that fibroblast growth factor 2 (FGF2) and FGF receptors (FGFRs) are frequently co-expressed in NSCLC...
  24. Danny J Schust; Fiscal Year: 2016
    ..from human embryonic stem cells (hESC) that have been treated with BMP4 (BMP-hESC) and inhibitors of activin and FGF2 signaling...
  25. Ales Cvekl; Fiscal Year: 2016
    ..In addition, FGF2 stimulates expression of a small group of microRNAs that targets 3'-UTR of c-Maf...
  26. Thanh Huu Tran; Fiscal Year: 2014
    ..and a transient increase in SC population, and such phenotypes may be caused by Sulf-mediated repression of FGF2 signaling during SC differentiation...
  27. ROBERT MICHAEL ROBERTS; Fiscal Year: 2016
    ..Aim 2 is to determine whether or not the various LIF-and FGF2-dependent piPSC at our disposal are superior donors than somatic cells for nuclear transfer...
  28. Monoclonal Antibody to FGF Receptor 2 for Treatment of Gastric and Other Cancers
    K Jin Kim; Fiscal Year: 2009
    ..In particular, FGF2 (basic FGF) is a powerful stimulator of angiogenesis, the new blood vessel formation needed by tumors to grow, ..
  29. FGF2 IN VASCULAR DISEASE
    Michael Reidy; Fiscal Year: 2001
    ..to quantitate the role of a gene in vivo by directly comparing the behavior of cells which can or cannot express FGF2 or FGFR1...
  30. Edward P Ingenito; Fiscal Year: 2016
    ..capacity in vitro, spontaneously form alveolar-like structures in matrigel and secrete growth factors including FGF2, FGF7, FGF10, and HGF that can promote remodeling...
  31. Xingbin Ai; Fiscal Year: 2014
    ..Aged skeletal muscle has reduced levels of FGF2 and elevated Wnts and TGF2, leading to decreased proliferation of resident stem cells (so called satellite cells) ..
  32. Ian M Bird; Fiscal Year: 2016
    ..to cause severe detrimental alterations in the functional angiogenic and NO synthetic responses to VEGF and FGF2 via alterations in specific G-protein coupling transducers (GNA14 and GNA14)...
  33. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..and identified the genes encoding Cdx4, Meisl, Pbx2, the E3 ligase Triadl, Mkp2, programmed cell death protein 5, FGF2, Yaf2, and TGFp2 as potential HoxAIO- target-genes...
  34. Christine M Finck; Fiscal Year: 2014
    ..2: Optimize derivation of distal airway cells through growth factor supplementation, specifically FGF2, 7,10...
  35. Melissa B Rogers; Fiscal Year: 2015
    ..The association of RUNX2 and Hes1 will be examined in MC3T3-E1 pre-osteoblasts that express BMP2 in response to FGF2. These findings will be confirmed in primary aortic valve interstitial cells and diseased valves from the CAVD ..
  36. Mechanism of keratinocyte RXRalpha mediated melanoma skin cancer development
    ARUP K INDRA; Fiscal Year: 2013
    ..RXR[unreadable], directly or indirectly, represses keratinocytic expression of endothelin 1 (ET-1), SCF, POMC and FGF2 which may serve to regulate melanocytic mitogenesis in a paracrine manner...
  37. Mina Mina; Fiscal Year: 2016
    ..The effects of FGF2 on proliferation and differentiation of [unreadable]SMACreERT2;Ai9 expressing cells will be examined in vivo after ..
  38. Syndecan-1 and the Arterial Response to Injury
    Alexander W Clowes; Fiscal Year: 2013
    ..of PDGF-B mRNA and migrate and proliferate more than SMCs from wild-type mice in response to PDGF-BB, serum, EGF, FGF2, and thrombin...
  39. L Darryl Quarles; Fiscal Year: 2016
    ..Activation of FGFR1/PI3K/Akt/?-catenin and HMW-FGF2-dependent integrative fibroblastic growth factor receptor signaling (INFS) appear to couple bone mineralization ..
  40. Jo El J Schultz; Fiscal Year: 2014
    ..provided by applicant): The overall goal of this proposal is to investigate the molecular target(s) underlying FGF2-mediated cardioprotection...
  41. Transcriptional Role of BRCA1 in Breast Cancer
    Wen Hwa Lee; Fiscal Year: 2012
    ..To elucidate regulatory modes of BRCA1-mediated, but ZBRK1 independent, transcriptional modulation of FGF2, RFC1, TIP30 and TFDP1;and Aim 3...
  42. Signaling mechanisms of FGF2-induced cardioprotection
    Jo El Schultz; Fiscal Year: 2009
    The overall goal of this proposal is to investigate the molecular target(s) underlying FGF2-mediated cardioprotection...
  43. Renato V Iozzo; Fiscal Year: 2016
    ..The parent proteoglycan is pro-angiogenic by acting as a co-receptor for FGF2 and VEGFA via the N-terminal heparin sulfate chains...
  44. Neurodevelopmental Underpinnings of Rodent Anxiety and Depressive Behavior
    Sarah M Clinton; Fiscal Year: 2013
    ..as maternal care; and 3) how early life manipulation of hippocampal circuitry (via exposure to the growth factor FGF2) impacts brain development and later emotional behavior...
  45. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..We will test the hypothesis that mediators of Fgf2 and Tgf-Beta2 activity are the same in MCC and SUT, and that they differ from mediators of Fgf2 and Tgf-Beta2 ..
  46. Roles of FGF2 and TGFbeta in cardiac hypertrophy
    Thomas Doetschman; Fiscal Year: 2005
    Roles of FGF2 and TGFbeta1 in cardiac hypertrophy...
  47. Recombinant Polymers for Systemic Cancer Gene Therapy
    Peter Swann; Fiscal Year: 2007
    ..the polymeric backbone, lysine (K) residues to condense plasmid DMA, a targeting ligand (fibroblast growth factor, FGF2) for biorecognition by cancer cells, histidine (H) residues to allow escape from the endosomes, and cysteine (C) ..
  48. NEUROTROPHIC SUPPORT IN AGING AND ALZHEIMERS DISEASE
    Felix Eckenstein; Fiscal Year: 2003
    DESCRIPTION: (Applicant's abstract) Basic fibroblast growth factor (FGF2) is a potent mitogen and neurotrophic factor. The mature CNS contains a surprisingly high level of this factor...
  49. HSP27/FGF2 REGULATION OF CELL MIGRATION IN BREAST CANCER
    RANDOLPH PIOTROWICZ; Fiscal Year: 2002
    ..endothelial cell migration in a wounding model, stimulated by the 18 kDa form of basic-fibroblast growth factor (FGF2), is likely to be attributable to HSP27's role as a regulator of the F-actin polymerization required for cell ..
  50. Kristen L Billiar; Fiscal Year: 2014
    ..such as transforming growth factor beta1 (TGF-beta1), endothelin-1 (ET-1), and fibroblast growth factor 2 (FGF2)...
  51. Gene Expression Analysis in Microcaptured Retinal Cells
    Ruben Adler; Fiscal Year: 2005
    ..brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), or basic fibroblast growth factor-2 (FGF2), slows photoreceptor cell death caused by specific mutations or exposure to constant light...
  52. Retinal gene expression changes during oxidative damage
    NAEL AL ABDULLA; Fiscal Year: 2007
    ..Expression of fibroblast growth factor 2 (FGF2) or brain-derived neurotrophic factor (BDNF) in the retina prevents hyperoxia-induced retinal degeneration...
  53. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2007
    ..five hypotheses by addressing the following Specific Aims: 1) Determine the concentration of CAR, integrins, and FGF2 receptor on fresh human HNSCC samples and derived cell lines; 2) Establish the correlation between expression of ..
  54. FIBROBLAST GROWTH FACTOR RECEPTORS IN CRANIOSYNOSTOSIS
    ETHYLIN JABS; Fiscal Year: 1999
    ..g., FGF1 and FGF2) binding properties of mutant FGFR2s; 6) altered ligand-activated tyrosine kinase activity of mutant FGFR2s, 7) ..
  55. Fibroblast Growth Factor Homologous Factors: Modulation of L-type Calcium Channel
    JESSICA AMENTA HENNESSEY; Fiscal Year: 2013
    ..are modulators of voltage-gated sodium channels and the Pitt lab has recently characterized the role of FGF13 in modulating voltage-gated sodium channels in the heart...
  56. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    Regina C Armstrong; Fiscal Year: 2010
    ..Importantly, our preliminary data in FGF2-I- mice demonstrates that it is possible to overcome chronic lesion effects on endogenous oligodendrocyte lineage ..
  57. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
    ..expression of FGF-2, Cox-1, Cox-2, Bcl related genes, prostaglandin synthesis and apoptosis in wild-type mice and FGF2 -/- mice treated at various times following systemic treatment with anti-CD3 or in DO11...
  58. INTRACELLULAR FGFS:NOVEL REGULATIONS OF CARDIAC NAV CHANNELS
    Jeanne M Nerbonne; Fiscal Year: 2012
    ..Parallel experiments will be completed on myocytes isolated from mice (Fgf13-/-) harboring a targeted disruption of the Fgf13 locus...
  59. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..Other factors such as FGF2, IGF-1 and mechanical stimulation, known to signal through MARK, also stimulate RUNX2 phosphorylation...
  60. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..Basic Fibroblast growth factor (FGF2) is expressed by cortical progenitor cells and increases their proliferation both in vitro and in vivo...
  61. ROLE OF FIBROBLAST GROWTH FACTORS IN PROSTATE GROWTH
    Michael Ittmann; Fiscal Year: 2003
    ..The investigators have shown increased expression of FGF7 and FGF2 in BPH that is correlated with epithelial and stromal proliferation, respectively...
  62. Stephen Waxman; Fiscal Year: 2016
    ..3. Study FHF2-mediated regulation of Nav1.7 and Nav1.8 Na channels that drive chronic pain. 4...
  63. HUMAN HEPATOCYTE GROWTH FACTORS
    WALLACE MC KEEHAN; Fiscal Year: 2006
    ..Whether FGF1 and/or FGF2 ablation in mice impacts compensatory growth of liver, cholesterol/bile acid metabolism and response to CCI4 damage ..
  64. Role of Heparan Sulfate in FGF Action
    ALAN RAPRAEGER; Fiscal Year: 2005
    ..FGF1 and FGF2 are the prototypes of the family initially described as promoting neuronal proliferation, neurite extension and ..
  65. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..kinetics of clearance of tagged Ap from the CP-CSF in aging and after flow inhibition induced by acetazolamide or FGF2, and Hi) characterize the age-modified expression of the Ap transporters, LRP-1 and the receptor for advanced ..
  66. Mechanistic Role of NELL-1 in Premature Suture Closure
    Kang Ting; Fiscal Year: 2003
    ..CBFA1 has recently been shown to play an important role in FGFR1 induced CS. TGF-beta1 and FGF2, which affect CBFA1 expression and induce cranial suture closure, induce NELL-1 expression in FRCC cells...
  67. Phase ii intraperitoneal rhIL 12
    Ralph Freedman; Fiscal Year: 2002
    ..Furthermore, decreased expression of the proangiogenic molecules FGF2 and VEGF on peritoneal cavity tumor was detected at higher dosing levels of IP rhIL- 12...
  68. KERATOCYTE CRYSTALLIN PROTEINS AND CORNEAL TRANSPARENCY
    JAMES JESTER; Fiscal Year: 2003
    ..of keratocyte crystallins in vitro and determine the effects of light/dark and cytokine stimulation (TGFbeta, IL1, FGF2, PDGF) on crystalline protein expression; and (5) modulate keratocyte crystalline protein expression in vivo by ..