FGF-2

Summary

Gene Symbol: FGF-2
Description: fibroblast growth factor 2
Alias: BFGF, FGF-2, FGFB, HBGF-2, fibroblast growth factor 2, basic fibroblast growth factor bFGF, fibroblast growth factor 2 (basic), heparin-binding growth factor 2, prostatropin
Species: human

Top Publications

  1. pmc HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway
    Feng Zhou
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People s Republic of China
    PLoS ONE 8:e53145. 2013
  2. pmc EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1
    Miguel Sáinz-Jaspeado
    Sarcoma Research Group, Laboratori d Oncologia Molecular, Institut d Investigació Biomèdica de Bellvitge IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    PLoS ONE 8:e71449. 2013
  3. ncbi Both hPTH(1-34) and bFGF increase trabecular bone mass in osteopenic rats but they have different effects on trabecular bone architecture
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 18:2105-15. 2003
  4. pmc Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells
    Valentina Masola
    Department of Experimental Biomedical Sciences, University of Padova, 35122 Padova, Italy
    J Biol Chem 287:1478-88. 2012
  5. ncbi The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 94:663-72. 1999
  6. pmc Interleukin-1β enhances cell migration through AP-1 and NF-κB pathway-dependent FGF2 expression in human corneal endothelial cells
    Jeong Goo Lee
    Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Biol Cell 105:175-89. 2013
  7. doi Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway
    X Zhu
    1 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, PR China 2 Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, PR China 3 Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, PR China 4 Department of Laboratory Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, PR China
    Oncogene 33:1986-96. 2014
  8. pmc Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells
    Tao Ren
    Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China
    Cancer Sci 105:186-94. 2014
  9. ncbi Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 163:1929-35. 1999
  10. pmc Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity
    Camilla Skiple Skjerpen
    Department of Biochemistry at The Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    EMBO J 21:4058-69. 2002

Research Grants

  1. Roles of FGF2 and TGFbeta in cardiac hypertrophy
    Thomas Doetschman; Fiscal Year: 2005
  2. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
  3. Patricio E Ray; Fiscal Year: 2016
  4. MICHELLE R GARCIA; Fiscal Year: 2014
  5. Pathogenesis of HIV-HUS in children
    Patricio E Ray; Fiscal Year: 2012
  6. William L Murphy; Fiscal Year: 2016
  7. Multipotent lung mesenchymal cells in neonatal lung injury
    Marc B Hershenson; Fiscal Year: 2010
  8. Dimitri T Azar; Fiscal Year: 2014
  9. Gadiparthi N Rao; Fiscal Year: 2016
  10. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010

Detail Information

Publications272 found, 100 shown here

  1. pmc HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway
    Feng Zhou
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People s Republic of China
    PLoS ONE 8:e53145. 2013
    ..Together, these results provide the first evidence that Tat might contribute to KS pathogenesis by synergizing with vIL-6, and identify PI3K/AKT pathway as a potential therapeutic target in AIDS-related KS patients...
  2. pmc EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1
    Miguel Sáinz-Jaspeado
    Sarcoma Research Group, Laboratori d Oncologia Molecular, Institut d Investigació Biomèdica de Bellvitge IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    PLoS ONE 8:e71449. 2013
    ..vitro, this phenomenon correlated with inactivation of EphA2 receptor, lack of AKT response and downregulation of bFGF. We also demonstrated that secreted bFGF from EWS cells acted as chemoattractant for endothelial cells...
  3. ncbi Both hPTH(1-34) and bFGF increase trabecular bone mass in osteopenic rats but they have different effects on trabecular bone architecture
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 18:2105-15. 2003
    ..Recently, bFGF has been found to increase trabecular bone mass in osteoporotic rats...
  4. pmc Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells
    Valentina Masola
    Department of Experimental Biomedical Sciences, University of Padova, 35122 Padova, Italy
    J Biol Chem 287:1478-88. 2012
    ..In conclusion, heparanase plays a role in the tubular-interstitial compartment favoring the FGF-2-dependent EMT of tubular cells. Hence, heparanase is an interesting pharmacological target for the prevention of renal fibrosis...
  5. ncbi The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 94:663-72. 1999
    ..the same time, the Tat basic sequence retrieves into a soluble form extracellular basic fibroblast growth factor (bFGF) bound to heparan sulfate proteoglycans by competing for heparin-binding sites...
  6. pmc Interleukin-1β enhances cell migration through AP-1 and NF-κB pathway-dependent FGF2 expression in human corneal endothelial cells
    Jeong Goo Lee
    Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Biol Cell 105:175-89. 2013
    ....
  7. doi Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway
    X Zhu
    1 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, PR China 2 Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, PR China 3 Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, PR China 4 Department of Laboratory Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, PR China
    Oncogene 33:1986-96. 2014
    ..These novel findings also suggest that targeting the PI3K/AKT signal may be a potentially effective therapeutic approach in AIDS-KS patients...
  8. pmc Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells
    Tao Ren
    Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China
    Cancer Sci 105:186-94. 2014
    ..Apurinic/apyrimidinic endonuclease 1 (APE1) and fibroblast growth factor 2 (FGF2) and its receptor 3 (FGFR3) signaling pathway plays an important role in the angiogenic process...
  9. ncbi Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 163:1929-35. 1999
    ..Inflammatory cytokines induce the tissue expression of both basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), two angiogenic molecules highly produced in primary KS lesions...
  10. pmc Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity
    Camilla Skiple Skjerpen
    Department of Biochemistry at The Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    EMBO J 21:4058-69. 2002
    ..A correlation between the mitogenic potential of FGF-1 mutants and their ability to bind to CK2 alpha was observed. The possible involvement of CK2 in the FGF-induced stimulation of DNA synthesis is discussed...
  11. doi Association between genetic polymorphisms in fibroblast growth factor (FGF)1 and FGF2 and risk of endometriosis and adenomyosis in Chinese women
    Shan Kang
    Department of Obstetrics and Gynaecology, Hebei Cancer Institute, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011, China
    Hum Reprod 25:1806-11. 2010
    ..We investigated whether FGF1 -1385A/G and FGF2 754C/G polymorphisms are associated with a risk of developing EM and adenomyosis...
  12. doi Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor-alpha in diverticular disease of the colon: a case-control study
    A Tursi
    Gastroenterology Service, ASL BAT, Andria Bt, Italy
    Neurogastroenterol Motil 24:836-e396. 2012
    ..We assessed the mucosal expression of bFGF, SD1, and TNF-α in DD according to the severity of the disease...
  13. doi Elevated serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder
    Xiaohua Liu
    Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China Electronic address
    Psychiatry Res 218:54-60. 2014
    ....
  14. ncbi Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2
    David C West
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    J Biol Chem 280:13457-64. 2005
    ..Npn-1 was also found to potentiate the growth stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins...
  15. ncbi FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus
    Jørgen Wesche
    Institute for Cancer Research at The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    J Biol Chem 281:11405-12. 2006
    ..The data indicate that the drugs block translocation from endosomes to the cytosol implying that Hsp90 is required for translocation of FGF-1 and FGF-2 across the endosomal membrane...
  16. pmc Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain
    Barbara Margosio
    Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Int J Biochem Cell Biol 40:700-9. 2008
    ..The finding that this domain is active in inhibiting angiogenesis indicates that the type III repeats represent a novel antiangiogenic domain of thrombospondin-1...
  17. doi YY1 Over-expression in human brain gliomas and meningiomas correlates with TGF-beta1, IGF-1 and FGF-2 mRNA levels
    Stavroula Baritaki
    Department of Clinical Virology, Medical School, University of Crete, Crete, Greece
    Cancer Invest 27:184-92. 2009
    ..We suggest that mRNA profiling of the above genes in the early stages of disease development could be useful for prognostic purposes, and these genes can be considered as potential targets for therapeutic approaches against brain tumors...
  18. pmc Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells
    Fang Zong
    Department of Laboratory Medicine, Division of Pathology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 4:e7346. 2009
    ..Our study opens a new perspective in the proteoglycan field and provides more evidence of nuclear interactions of syndecan-1...
  19. pmc Activation of matrix-metalloproteinase-2 and membrane-type-1-matrix-metalloproteinase in endothelial cells and induction of vascular permeability in vivo by human immunodeficiency virus-1 Tat protein and basic fibroblast growth factor
    E Toschi
    Laboratory of Virology, Istituto Superiore di Sanita, 00161 Rome, Italy
    Mol Biol Cell 12:2934-46. 2001
    ..Specifically, extracellular Tat cooperates with basic fibroblast growth factor (bFGF) in promoting KS and endothelial cell growth and locomotion and in inducing KS-like lesions in vivo...
  20. ncbi Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells
    Marwan E El-Sabban
    Department of Human Morphology, Faculty of Medicine, American University of Beirut, Lebanon
    Blood 99:3383-9. 2002
    ..secrete biologically active forms of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and, accordingly, induce angiogenesis in vitro...
  21. pmc Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis
    Marianne Valesky
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Med 8:103-12. 2002
    ..of human melanoma are their high degree of vascularity and high-level expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1)...
  22. pmc Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Mol Cancer 4:14. 2005
    ..Since pancreatic cancers over-express a number of heparin-binding growth factors and their receptors, the expression and function of this enzyme in pancreatic cancer was analyzed...
  23. ncbi Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
    ..This signaling pattern is similar to the autocrine-paracrine mechanism which operates in endothelial cells to support neovascular growth...
  24. doi Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2
    David I R Holmes
    Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, United Kingdom
    Cell Signal 20:569-79. 2008
    ..These findings support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability...
  25. doi Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1
    Haijie Yang
    Research Laboratories, National Neuroscience Institute, Singapore 308433
    J Biol Chem 283:5287-95. 2008
    ..In this report, we have demonstrated that basic fibroblast growth factor (bFGF) alone effectively induces mouse BMSC neuronal differentiation...
  26. doi FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells
    Kyung Ae Yoon
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, South Korea
    J Cell Physiol 220:245-56. 2009
    ..Our results indicate that ERM directly regulates Sdf-1 gene expression by interacting with its cis-acting element in response to FGF2 stimulation in TM4 cells...
  27. pmc Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
    Veronica C Ardi
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:25854-66. 2009
    ....
  28. pmc Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1
    Youli Hu
    Centre for Neuroendocrinology, University College London Medical School, Royal Free Campus, London NW32PF
    J Biol Chem 284:29905-20. 2009
    ..FGF2.heparin complex...
  29. doi Effect of bFGF on invasion of ovarian cancer cells through the regulation of Ets-1 and urokinase-type plasminogen activator
    Ting Li
    Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Affiliated to Tongji University, Shanghai, China
    Pharm Biol 48:161-5. 2010
    The aim of the study was to explore the role of basic fibroblast growth factor (bFGF) in ovarian cancer progression...
  30. pmc HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells
    Ashwani Khurana
    Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 71:2152-61. 2011
    ..03 and P ≥ 0.0001, respectively). Collectively, these results reveal an important link between loss of HSulf-1 under hypoxic microenvironment and increased growth factor signaling, cell migration, and invasion...
  31. doi A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes
    Louise J Hutley
    Metabolic Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland 4101, Australia
    Mol Cell Endocrinol 339:165-71. 2011
    ..These results suggest that changes in endogenous FGF-2 levels contribute to FGF-1's early adipogenic effects and highlight the complexity of the paracrine interplay between FGFs within human AT...
  32. pmc Caveolin-1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae
    Lin Feng
    Department of Obstetrics and Gynecology, University of California Irvine, Irvine, California 92697, USA
    J Cell Physiol 227:2480-91. 2012
    ....
  33. doi FGF-2 and Anosmin-1 are selectively expressed in different types of multiple sclerosis lesions
    Diego Clemente
    Grupo de Neurobiología del Desarrollo GNDe, Hospital Nacional de Parapléjicos Servicio de Salud de Castilla La Mancha, Finca La Peraleda s n, E 45071 Toledo, Spain
    J Neurosci 31:14899-909. 2011
    ....
  34. ncbi Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
    M Mohammadi
    Department of Pharmacology, New York University Medical Center, New York, NY 10016, USA
    Science 276:955-60. 1997
    ..This structural information will facilitate the design of new inhibitors for use in the treatment of cancer and other diseases in which cell signaling by tyrosine kinases plays a crucial role in disease pathogenesis...
  35. ncbi Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors
    Sarah Knox
    Commonwealth Scientific Industrial Research Organization CSIRO Molecular Science, North Ryde 2113, Australia
    J Biol Chem 277:14657-65. 2002
    ....
  36. ncbi Genetic variation in the promoter region of the basic fibroblast growth factor gene
    Michal Beranek
    Centre of Biostatistics and Analyses, Brno, Czech Republic
    Hum Immunol 64:374-7. 2003
    Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes...
  37. doi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
    b>Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis...
  38. ncbi Three-dimensional structures of acidic and basic fibroblast growth factors
    X Zhu
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125
    Science 251:90-3. 1991
    ..These sites include beta-sheet strand 10, which is adjacent to the site of an extended sequence insertion in several oncogene proteins of the FGF family, and which shows sequence conservation among the FGF family and interleukin-1 beta...
  39. pmc Three-dimensional structure of human basic fibroblast growth factor
    A E Eriksson
    Institute of Molecular Biology, Department of Physics, University of Oregon, Eugene
    Proc Natl Acad Sci U S A 88:3441-5. 1991
    The three-dimensional structure of human basic fibroblast growth factor (bFGF) has been determined by x-ray crystallography and refined to a crystallographic residual of 17.4% at 2.2-A resolution...
  40. pmc Human basic fibroblast growth factor: nucleotide sequence and genomic organization
    J A Abraham
    EMBO J 5:2523-8. 1986
    ..All of the basic, heparin-binding endothelial cell mitogens of similar amino acid composition that have been described must therefore be products of this single gene...
  41. ncbi Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
    B Ensoli
    Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Nature 371:674-80. 1994
    Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice...
  42. pmc Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
    M Mohammadi
    Department of Pharmacology, New York University Medical Center, 10016, USA
    Mol Cell Biol 16:977-89. 1996
    ..Binding of the Grb2/Sos complex to phosphorylated Shc and pp90 may therefore be the key link between FGFR1 and the Ras signaling pathway, mito-genesis, and neuronal differentiation...
  43. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways...
  44. ncbi High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy
    F J Moy
    Department of Structural Biology, Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Biochemistry 35:13552-61. 1996
    ..9 A resolution X-ray structure by Zhu et al. (1991) yields a backbone atomic rms difference of 0.94 A, indicative of a close similarity between the NMR and X-ray structures...
  45. ncbi Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization
    C Perollet
    Growth Factor and Cell Differentiation Laboratory, University Bordeaux Institut des Vaisseaux et du Sang, Paris, France
    Blood 91:3289-99. 1998
    ..These results indicate that PF-4 interacts with FGF-2 by complex formation, inhibiting FGF-2 dimerization, binding to FGF receptors, and internalization. This mechanism most likely contributes to the antiangiogenic properties of PF-4...
  46. pmc Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2
    S Ortega
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 95:5672-7. 1998
    ....
  47. pmc A new 34-kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor
    E Arnaud
    INSERM U397, Endocrinologie et Communication Cellulaire, Institut Louis Bugnard, C H U Rangueil, 31403 Toulouse Cedex 04, France
    Mol Cell Biol 19:505-14. 1999
    Four isoforms of human fibroblast growth factor 2 (FGF-2) result from alternative initiations of translation at three CUG start codons and one AUG start codon...
  48. ncbi Structural basis for FGF receptor dimerization and activation
    A N Plotnikov
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Cell 98:641-50. 1999
    ..A general model for FGF- and heparin-induced FGFR dimerization is inferred from the crystal structure, unifying a wealth of biochemical data...
  49. ncbi Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
    A N Plotnikov
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Cell 101:413-24. 2000
    ..These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing...
  50. ncbi Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
    J Schlessinger
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 6:743-50. 2000
    ..This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling...
  51. pmc Fibroblast growth factors
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Genome Biol 2:REVIEWS3005. 2001
    ..When inappropriately expressed, some FGFs can contribute to the pathogenesis of cancer. A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems...
  52. pmc Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
    O A Ibrahimi
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:7182-7. 2001
    ..substitutions cause AS, we determined the crystal structures of these two FGFR2 mutants in complex with fibroblast growth factor 2 (FGF2)...
  53. ncbi Identification of a new fibroblast growth factor receptor, FGFR5
    M Sleeman
    Genesis Research and Development Corporation Ltd, 1 Fox Street, Parnell, Auckland, New Zealand
    Gene 271:171-82. 2001
    ..However, biological data suggest that FGF-2 binding to these proteins is with lower affinity than its cognate receptor FGFR2C. The above data indicate that this receptor should be considered as the fifth member of the FGFR family...
  54. ncbi Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism
    Dayanand D Deo
    Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:21237-45. 2002
    ..We have shown that basic fibroblast growth factor (bFGF) supplementation induces rapid proliferation of human umbilical vein endothelial cells (HUVEC), which is reduced ..
  55. pmc Expression of basic fibroblast growth factor is associated with poor outcome in non-Hodgkin's lymphoma
    I Pazgal
    Institute of Hematology and Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Petah Tiqva, 49100, Israel
    Br J Cancer 86:1770-5. 2002
    ....
  56. ncbi Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro
    Patricia Collin-Osdoby
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    J Bone Miner Res 17:1859-71. 2002
    ..adjacent to a bone chip was used to investigate if a potent angiogenic stimulator, basic fibroblast growth factor (bFGF), could promote OC recruitment, differentiation, and resorption in vivo...
  57. ncbi Immunohistochemical expression of basic fibroblast growth factor, vascular endothelial growth factor, and their receptors in stage IV non-Hodgkin lymphoma
    Ching Liang Ho
    Division of Hematopathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Appl Immunohistochem Mol Morphol 10:316-21. 2002
    ..of two important angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), are associated with a poor prognosis...
  58. ncbi Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma
    Friedegund Meier
    Department of Dermatology, University of Tuebingen, Germany
    Exp Dermatol 12:296-306. 2003
    ..The described results of the current and previous studies emphasise the key role of FGF-2 in melanoma development and progression, underscoring the promise of FGF-2 as a target for therapy...
  59. ncbi Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth
    Roger G Fahmy
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Nat Med 9:1026-32. 2003
    ..Egr-1 DNAzymes also repressed neovascularization of rat cornea. Thus, microvascular endothelial cell growth, neovascularization, tumor angiogenesis and tumor growth are processes that are critically dependent on Egr-1...
  60. ncbi Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells
    Simona Taverna
    Dipartimento Biologia Cellulare e dello Sviluppo, Universita di Palermo, Palermo 90128, Italy
    J Biol Chem 278:51911-9. 2003
    ..The comparison of the stimulatory effects of shed vesicles and vesicle-free conditioned medium showed that vesicles represent a major reservoir of FGF-2. Thus, FGF-2 can be released from cells through vesicle shedding...
  61. pmc Spider angiomas in patients with liver cirrhosis: role of vascular endothelial growth factor and basic fibroblast growth factor
    Chung Pin Li
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    World J Gastroenterol 9:2832-5. 2003
    To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated with spider angiomas in patients with liver cirrhosis.
  62. ncbi hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling
    Jin Ping Lai
    Division of Gastroenterology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gastroenterology 126:231-48. 2004
    ..Heparin-binding growth factor signaling is regulated by sulfation of cell-surface heparan sulfate proteoglycans (HSPGs). We hypothesized that hSulf1, a recently described sulfatase, regulates growth signaling in HCCs...
  63. ncbi Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma
    Francis J Giles
    Department of Leukemia, MD Anderson Cancer Center, The University of Texas, PO Box 428, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Leuk Res 28:595-604. 2004
    Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and angiogenin are important angiogenic factors...
  64. ncbi Growth factor production in human endothelial cells after Chlamydia pneumoniae infection
    Dirk Prochnau
    Department of Internal Medicine Cardiology, Friedrich Schiller University of Jena, Jena, Germany
    Int J Med Microbiol 294:53-7. 2004
    ..pneumoniae on expression of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in human endothelial cells...
  65. ncbi Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers
    Guangwen Wang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    Biochem Biophys Res Commun 330:934-42. 2005
    ..Furthermore, we found that the combination of noggin and basic fibroblast growth factor (bFGF) was sufficient to maintain the prolonged growth of hES cells while retaining all hES cell features...
  66. ncbi Basic fibroblast growth factor (FGF-2) overexpression is a risk factor for esophageal cancer recurrence and reduced survival, which is ameliorated by coexpression of the FGF-2 antisense gene
    Christie Barclay
    Department of Physiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Cancer Res 11:7683-91. 2005
    ..The aim of this study was to characterize FGF-2 and FGF-AS in esophageal cancer and to correlate their expression with clinicopathologic findings and outcome...
  67. pmc Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes
    Richard F Loeser
    Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 52:3910-7. 2005
    To determine the effects of basic fibroblast growth factor (bFGF) on the chondrocyte anabolic activity promoted by insulin-like growth factor 1 (IGF-1) and osteogenic protein 1 (OP-1).
  68. pmc Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    Xiuqin Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:15694-700. 2006
    ..This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity...
  69. ncbi Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells
    Laure Emmanuelle Zaragosi
    Institut de Recherche, Signalisation, Biologie du Développement et Cander, UMR6543 Centre National de la Recerche Scientifique, Centre de Biochimie, Faculte des Sciences, Université Nice Sophia Antiplis, Nice, France
    Stem Cells 24:2412-9. 2006
    ..This decrease is associated with a decrease in fibroblast growth factor 2 (FGF2) expression and can be circumvented by chronic treatment with exogenous FGF2...
  70. ncbi Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion
    Marco Timmer
    Department of Neuroanatomy, Hannover Medical School, Center for Systems Neuroscience Hannover, 30625 Hannover, Germany
    J Neurosci 27:459-71. 2007
    ..The lack of FGF-2 seems to be (over)compensated during development, but, after lesion, compensation mechanisms fail. The transgenic mice showed that endogenous FGF-2 protects DA neurons from 6-OHDA neurotoxicity...
  71. ncbi Chromatin compaction and cell death by high molecular weight FGF-2 depend on its nuclear localization, intracrine ERK activation, and engagement of mitochondria
    Xin Ma
    Institute of Cardiovascular Sciences, SBRC, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Physiol 213:690-8. 2007
    b>Fibroblast growth factor 2 (FGF-2) is produced as CUG-initiated, 22-34 kDa or AUG-initiated 18 kDa isoforms (hi- and lo-FGF-2, respectively), with potentially distinct functions...
  72. ncbi The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cytokine Growth Factor Rev 18:327-34. 2007
    ..This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature...
  73. ncbi Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells
    Natsuko Kakudo
    Department of Plastic and Reconstructive Surgery, Kansai Medical University, 10 15 Fumizono, Moriguchi, Osaka, Japan
    Biochem Biophys Res Commun 359:239-44. 2007
    ..The results of FGF-2 supplementation suggest the potential applications of FGF-2 and ASCs in adipose tissue regeneration...
  74. pmc Candidate gene and locus analysis of myopia
    Donald O Mutti
    College of Optometry, The Ohio State University, Columbus, OH 43210 1240, USA
    Mol Vis 13:1012-9. 2007
    ..We attempted to replicate these findings and to conduct a candidate gene and locus evaluation of genetic involvement in common forms of myopia...
  75. pmc FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability
    Frederique M D Tholozan
    School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, United Kingdom
    Mol Biol Cell 18:4222-31. 2007
    ..The lens capsule is also a source of soluble factors including fibroblast growth factor 2 (FGF-2) and perlecan, an extracellular matrix component that enhances FGF-2 activity...
  76. ncbi Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes
    Prasuna Muddasani
    Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 282:31409-21. 2007
    The pathology of joint destruction is associated with elevated production of basic fibroblast growth factor (bFGF) and matrix metalloproteinase-13 (MMP-13)...
  77. pmc Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor (FGF-2): a novel mechanism for the control of FGF-2 and thrombin activity
    P J Yu
    Department of Cardiothoracic Surgery, The Seymour Cohn Cardiovascular Research Laboratory, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 27:2594-601. 2008
    ..This post-translational control mechanism adds a novel level of complexity to the regulation of FGF-2, and links the activities of thrombin and FGF-2 in patho-physiological processes in which both molecules are expressed...
  78. doi VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Atherosclerosis 200:51-7. 2008
    ..These results indicate that the FGF-2-mediated enhancement of PlGF expression was dependent on VEGF function, and the FGF-2/VEGF axis participates in FGF-2-mediated angiogenesis indirectly via PlGF as well as directly...
  79. doi Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes
    Mojca Globocnik Petrovic
    Eye Clinic, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Clin Exp Ophthalmol 36:168-72. 2008
    Basic fibroblast growth factor (bFGF) expression is implicated in proliferative diabetic retinopathy (PDR)...
  80. doi Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms
    Sarah J Goodger
    Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK
    J Biol Chem 283:13001-8. 2008
    ..We propose that, depending on saccharide structure, there are different architectures and modes of ternary complex assembly that differ in stability and/or efficiency of transmembrane signaling...
  81. doi Active caspase-1 is a regulator of unconventional protein secretion
    Martin Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 132:818-31. 2008
    ..By this mechanism, stress-induced activation of caspase-1 directly links inflammation to cytoprotection, cell survival, and regenerative processes...
  82. doi A direct role for phosphatidylinositol-4,5-bisphosphate in unconventional secretion of fibroblast growth factor 2
    Koen Temmerman
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Traffic 9:1204-17. 2008
    b>Fibroblast growth factor 2 (FGF-2) is a mitogen that is exported from cells by an endoplasmic reticulum/Golgi-independent secretory pathway...
  83. doi Expression of angiogenesis-related genes regulates different steps in the process of tumor growth and metastasis in human urothelial cell carcinoma of the urinary bladder
    M Chikazawa
    Department of Urology, Kochi Medical School, Nankoku, Kochi, Japan
    Pathobiology 75:335-45. 2008
    ..This study was designed to determine the relative activity of angiogenesis-related genes in the regulation of tumorigenicity and subsequent metastases of urothelial cell carcinomas (UC) of the urinary bladder...
  84. doi Upregulation of fibroblast growth factor-2 by visfatin that promotes endothelial angiogenesis
    Yun Hee Bae
    Department of Physiology, School of Medicine, Pusan National University, Busan 602 739, South Korea
    Biochem Biophys Res Commun 379:206-11. 2009
    ..These data further suggest an integral role for visfatin-FGF-2 signaling axis in modulating endothelial angiogenesis...
  85. pmc Sclera-related gene polymorphisms in high myopia
    Hui Ju Lin
    Department of Ophthalmology, China Medical University Hospital, Taichung 404, Taiwan
    Mol Vis 15:1655-63. 2009
    Transforming growth factor-beta2 (TGF-beta2), basic fibroblast growth factor (bFGF), and fibromodulin (FMOD) are important extracellular matrix components of the sclera and have been shown to be associated with the development of high ..
  86. ncbi Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer
    D Marzioni
    Department of Molecular Pathology and Innovative Therapies, Marche Polytechnic University, School of Medicine, Ancona, Italy
    Int J Immunopathol Pharmacol 22:627-38. 2009
    Basic fibroblast growth factor (bFGF) is a heparin-binding cationic protein involved in a variety of pathological conditions including angiogenesis and solid tumour growth...
  87. ncbi Polymorphisms in the promoter region of the basic fibroblast growth factor gene are not associated with myocardial infarction in a Slovene population with type 2 diabetes
    S Kariz
    Izola General Hospital, Izola, Slovenia
    J Int Med Res 37:1596-603. 2009
    Basic fibroblast growth factor (bFGF) is a multifunctional growth factor that may play a significant role in atherosclerotic vascular complications in patients with type 2 diabetes...
  88. pmc The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury
    Siyun Liao
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 48:1245-54. 2010
    b>Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low [LMW] and high molecular weight [HMW]), which are localized to different cellular compartments, indicating unique biological activity...
  89. pmc Fibroblast growth factor type 2 signaling is critical for DNA repair in human keratinocyte stem cells
    Ghida Harfouche
    CEA, IRCM, Laboratory of Genomics and Radiobiology of Keratinopoiesis, Evry, France
    Stem Cells 28:1639-48. 2010
    ..We propose that, apart from its well-known role as a strong mitogen and prosurvival factor, FGF2 helps to maintain genomic integrity in stem cells by activating stress-induced DNA repair...
  90. pmc Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway
    Chunwei Shi
    Department of Obstetrics and Gynecology, St Joseph s Hospital and Medical Center, Phoenix, Arizona, United States of America
    PLoS ONE 6:e21482. 2011
    ..Limited data suggest its involvement in cell migration and apoptosis. However, the underlying signaling mechanisms and novel functions of ECSM2 remain to be explored...
  91. doi Overexpression of human HMW FGF-2 but not LMW FGF-2 reduces the cytotoxic effect of lentiviral gene transfer in human corneal endothelial cells
    Monika Valtink
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, Dresden, Germany
    Invest Ophthalmol Vis Sci 53:3207-14. 2012
    ..The effect of FGF-2 overexpression of each of the five known isoforms on HCEC cell survival after lentiviral gene transfer in different culture media was investigated...
  92. doi Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1
    Natalia Platonova
    INSERM U1029, Talence, France
    Blood 121:1229-37. 2013
    ..It is well established that fibroblast growth factor 2 (FGF2) induces lymphangiogenesis...
  93. doi MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth
    Bisheng Zhou
    Key Laboratory of Molecular Biophysics of the Ministry of Education, Department of Genetics and Developmental Biology, College of Life Science and Technology, Center for Human Genome Research, Cardio X Institute, Huazhong University of Science and Technology, Wuhan, PR China
    Cancer Lett 333:159-69. 2013
    ....
  94. doi Fibroblast growth factor 2 is of prognostic value for patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:68-74. 2014
    Patients with locally advanced SCCHN have a poor prognosis. This study investigated the prognostic value of the tumor cell expression of the fibroblast growth factor 2 (FGF-2) in patients treated with surgery followed by radiotherapy.
  95. pmc Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion
    Stacey J Coleman
    Centre for Tumour Biology Barts Cancer Institute a CRUK Centre of Excellence, Queen Mary University of London, London, UK
    EMBO Mol Med 6:467-81. 2014
    ..These findings suggest a novel therapeutic approach, where preventing nuclear FGF/FGFR mediated proliferation and invasion in PSCs leads to disruption of the tumour microenvironment, preventing pancreatic cancer cell invasion. ..
  96. pmc Down-modulation of monocyte transendothelial migration and endothelial adhesion molecule expression by fibroblast growth factor: reversal by the anti-angiogenic agent SU6668
    Hong Zhang
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Pathol 160:2219-30. 2002
    Basic and acidic fibroblast growth factor (bFGF and aFGF, respectively) and vascular endothelial growth factor (VEGF) exert angiogenic actions and have a role in wound healing, inflammation, and tumor growth...
  97. ncbi The human basic fibroblast growth factor gene is located on the long arm of chromosome 4 at bands q26-q27
    M Lafage-Pochitaloff
    U 119 INSERM, Marseille, France
    Oncogene Res 5:241-4. 1990
    ..This location is on the same chromosome as that of a related gene, FGF.5, but on a distinct region...
  98. ncbi Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity
    A Chellaiah
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:34785-94. 1999
    ..These data demonstrate that multiple regions of the FGFR regulate ligand binding specificity and that these regions are distinct with respect to different members of the FGF family...
  99. ncbi Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
    I Ding
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892-1002, USA
    Acta Oncol 36:337-40. 1997
    ..FGF2 may prove a useful treatment response modifier in clinical fractionated irradiation...
  100. ncbi Expression and localization of basic fibroblast growth factor and its mRNA in solitary fibrous tumor
    X Li
    Department of Pathology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:384-92. 2001
    ..Basic fibroblast growth factor (bFGF or FGF-2) is a mitogenic and angiogenic polypeptide produced by diverse cell types, including the cells derived ..

Research Grants67

  1. Roles of FGF2 and TGFbeta in cardiac hypertrophy
    Thomas Doetschman; Fiscal Year: 2005
    ..For each growth factor the pathways that correlate with hypertrophy, pressure overload, activation of the renin angiotensin system, or upregulation of fetal cardiac genes will be assessed. ..
  2. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..transcription is rapidly induced in endothelial cells in response to angiogenic signals, mediated by fibroblast growth factor 2 and epidermal growth factor...
  3. Patricio E Ray; Fiscal Year: 2016
    ....
  4. MICHELLE R GARCIA; Fiscal Year: 2014
    ..factors known to regulate luteal angiogenesis including vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2)...
  5. Pathogenesis of HIV-HUS in children
    Patricio E Ray; Fiscal Year: 2012
    ....
  6. William L Murphy; Fiscal Year: 2016
    ..This proposed research program will develop a new class of materials that can be used to control the effects of growth factors during engineered tissue development, particularly vascular tissue development. ..
  7. Multipotent lung mesenchymal cells in neonatal lung injury
    Marc B Hershenson; Fiscal Year: 2010
    ..epithelial growth and repair, inhibits squamous differentiation and contains basic fibroblast growth factor (bFGF/FGF-2), keratinocyte growth factor (KGF) and vascular endothelial cell growth factor (VEGF)...
  8. Dimitri T Azar; Fiscal Year: 2014
    ..Transcriptional up regulation of VEGF and pericellular/transcellular ECM degradation may be two distinct mechanisms by which enzymatically active MT1-MMP promotes angiogenesis. ..
  9. Gadiparthi N Rao; Fiscal Year: 2016
    ....
  10. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
    ..In our earlier study, we showed that fibroblast growth factor 2 (FGF-2) is the direct mediator of EMT...
  11. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2012
    ..is to thoroughly characterize a humanized monoclonal antibody (mAb) that binds and inhibits human Fibroblast Growth Factor 2 (FGF2;basic FGF) for potential use in cancer therapy...
  12. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2010
    ..objective of the proposed research is to characterize a monoclonal antibody (mAb) that binds and blocks Fibroblast Growth Factor 2 (FGF2) for potential use in cancer therapy...
  13. Huntington's Disease and Neurogenesis
    Lisa M Ellerby; Fiscal Year: 2012
    ..We are developing a potential therapy to protect neurons or replace them in Huntington's disease. ..
  14. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..data showing that in addition to its role in promoting osteoblast (OB) function and bone formation, fibroblast growth factor 2 (FGF2) is a negative regulator of mesenchymal stem cell differentiation into mature adipocytes (AD)...
  15. Ian M Bird; Fiscal Year: 2016
    ..This leads to indepth understanding of the inter/intracellular mechanisms at the maternal-fetal interface in normal and abnormal pregnancies (e.g. preeclampsia with lUGR). ..
  16. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..Knowledge thus gained will help us to advance towards our long-term objective to develop RNA interference based therapies to treat HIV infection and counteract the deleterious effects of opioid-abuse. ..
  17. Ales Cvekl; Fiscal Year: 2016
    ....
  18. Gadiparthi N Rao; Fiscal Year: 2015
    ....
  19. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..this line, we have designed and synthesized several bioactive peptides, such as FGF-P (binding domain of fibroblast growth factor 2), TPO-P (binding domain shared by thrombopoietin and erythropoietin) and NPY (Neuropeptide Y) and ..
  20. Generation of a Novel Therapeutic for Prostate Cancer Bone Metastasis
    DONALD EDWARD STAUNTON; Fiscal Year: 2010
    ..This new drug may ultimately be used to treat several types of cancer. ..
  21. Thanh Huu Tran; Fiscal Year: 2014
    ..We will also utilize lentivirus expressing the dominant negative Sulf2 to acutely inactivate Sulfs. ..
  22. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..The data will provide a foundation for clarifying the underlying potential pathological mechanisms of MDD in HIV-infected individuals. ..
  23. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ....
  24. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..Both aspects may offer promising leads to correct or reverse the excitatory and inhibitory neuron imbalances that are present in the cerebral cortex of neuropsychiatric and impulse control disorders. ..
  25. Injury and Recovery in Developing Brain
    Flora M Vaccarino; Fiscal Year: 2013
    ..The factors under investigation include Fibroblast growth factor 2 (FGF2), the Epidermal growth factor receptor (EGFR), TrkB and its ligand Brain derived neurotropic ..
  26. Selection of Therapeutic Agents for Articular Cartilage Repair
    Stephen B Trippel; Fiscal Year: 2013
    ..This research project is designed to determine which potential therapeutic agents are good candidates for articular cartilage gene therapy. ..
  27. Rashmi Bansal; Fiscal Year: 2016
    ....
  28. Katia Del Rio-Tsonis; Fiscal Year: 2014
    ..their retina, following retinectomy, via the process of trans-differentiation if exposed to ectopic fibroblast growth factor 2 (FGF2)...
  29. MARJA MARIE HURLEY; Fiscal Year: 2016
    ..Our studies support an important role for the nuclear isoforms of Fibroblast Growth Factor 2 (FGF2) in FGF23 production and biologic function...
  30. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    ....
  31. Neurodevelopmental Basis of Anxiety and Depressive Behavior
    Sarah M Clinton; Fiscal Year: 2010
    ..Ultimately this work hopes to improve our understanding of the neurobiology of emotional disorders and help to develop improved treatments. ..
  32. LIISA TIINA KUHN; Fiscal Year: 2016
    ....
  33. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
    ..This leads us to the hypothesis that FGF receptors act cell autonomously in the absence of injury to suppress astrogliosis. ..
  34. David M Ornitz; Fiscal Year: 2015
    ..This knowledge will be essential to effectively design and implement FGF-based therapies for the treatment of human CVD. ..
  35. Ningjun Li; Fiscal Year: 2014
    ..abstract_text> ..
  36. Dvelopment of multi-component peptide vehicles for in vivo neuronal gene therapy
    Ester J Kwon; Fiscal Year: 2010
    ..and differentiation of NPCs through the delivery of therapeutic genes encoding mitogenic factors such as fibroblast growth factor 2 (FGF2) can cause increased recruitment to damaged areas in the brain...
  37. Marco C Bottino; Fiscal Year: 2016
    ....
  38. FGF-2 Autocrine Signaling in Lung Cancer
    Lynn E Heasley; Fiscal Year: 2012
    ..Importantly, we show that fibroblast growth factor 2 (FGF2) and FGF receptors (FGFRs) are frequently co-expressed in NSCLC...
  39. GROWTH FACTOR BIOAVAILABILITY AND GINGIVAL OVERGROWTH
    MARY FARACH CARSON; Fiscal Year: 2000
    ..Basic fibroblast growth factor (bFGF), also called fibroblast growth factor 2 (FGF-2), has been implicated in the development of overgrowth disease, including that of the gingiva...
  40. FGF2 IN VASCULAR DISEASE
    Michael Reidy; Fiscal Year: 2001
    ..The applicant will test the hypothesis that FGFR1 regulates two processes important for vascular pathologies: the initial mitogenic stimulation of cells and the movement of cells into the intima and/or sites of neovascularization. ..
  41. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ....
  42. Danny J Schust; Fiscal Year: 2016
    ..We will test this hypothesis in vitro using iPSCs derived from the umbilical cords of babies born to mothers with severe preeclampsia and gestational age-matched control iPSCs. ..
  43. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Therefore, the goal of these studies is to identify novel targets for the treatment of myeloid malignancy. ..
  44. ROBERT MICHAEL ROBERTS; Fiscal Year: 2016
    ..As the pig is an important reservoir for Salmonella, the LDLR-/- model will have a dual purpose for both agricultural and biomedical applications. ..
  45. Melissa B Rogers; Fiscal Year: 2015
    ..End of Abstract) ..
  46. Mechanism of keratinocyte RXRalpha mediated melanoma skin cancer development
    ARUP K INDRA; Fiscal Year: 2013
    ..abstract_text> ..
  47. Mina Mina; Fiscal Year: 2016
    ..These findings will be critical for the development of improved treatments for vital pulp therapy and improved dentin regeneration. ..
  48. Syndecan-1 and the Arterial Response to Injury
    Alexander W Clowes; Fiscal Year: 2013
    ....
  49. Edward P Ingenito; Fiscal Year: 2016
    ..This trial design will allow us to recover the LMSC-treated organ for histological analysis to characterize responses to LMSC treatment at the cellular level. ..
  50. Xingbin Ai; Fiscal Year: 2014
    ..Our findings may open new venues for prevention and therapy of aging-related impairment of skeletal muscle regeneration. ..
  51. L Darryl Quarles; Fiscal Year: 2016
    ..Such knowledge will help us understand and better manage patients with hyperphosphatemic and hypophosphatemic disorders. ..
  52. Jo El J Schultz; Fiscal Year: 2014
    ..Results of this proposal will provide new insights into FGF2-induced cardioprotection and may eventually lead to the pharmacologic or genetic development of FGF2 as a therapy against ischemic heart disease. ..
  53. Transcriptional Role of BRCA1 in Breast Cancer
    Wen Hwa Lee; Fiscal Year: 2012
    ..Especially, these natural factors that specifically suppress proliferation and induce breast cancer cell death will potentially provide a novel tumor dormancy therapy for treating breast cancer. ..
  54. Signaling mechanisms of FGF2-induced cardioprotection
    Jo El Schultz; Fiscal Year: 2009
    ..Results of this proposal will provide new insights into FGF2-induced cardioprotection and may eventually lead to the pharmacologic or genetic development of FGF2 as a therapy against ischemic heart disease. ..
  55. Renato V Iozzo; Fiscal Year: 2016
    ....
  56. Christine M Finck; Fiscal Year: 2014
    ..2: Optimize derivation of distal airway cells through growth factor supplementation, specifically FGF2, 7,10. 3: Optimize spatial cues utilizing 3-dimensional hydrogel scaffolds with potential transplantation in vivo, time permitting. ..
  57. Neurodevelopmental Underpinnings of Rodent Anxiety and Depressive Behavior
    Sarah M Clinton; Fiscal Year: 2013
    ..The overarching goal of the proposed research is to identify neurodevelopmental mechanisms that may underlie key aspects of individual differences in emotionality and susceptibility to depression and anxiety. ..
  58. NEUROTROPHIC SUPPORT IN AGING AND ALZHEIMERS DISEASE
    Felix Eckenstein; Fiscal Year: 2003
    ..The volume of hippocampus, neuronal and glial numbers, and cytoarchitecture of hippocampus of old FGF2 knockout and FGF-2 overexpressing mice will be determined. ..
  59. HSP27/FGF2 REGULATION OF CELL MIGRATION IN BREAST CANCER
    RANDOLPH PIOTROWICZ; Fiscal Year: 2002
    ..In addition, other consequences of the HMW FGF2/HSP27 interaction (e.g., FGF2 sequestering or nuclear translocation ) will be investigated. ..
  60. Kristen L Billiar; Fiscal Year: 2014
    ..in response to cytokines such as transforming growth factor beta1 (TGF-beta1), endothelin-1 (ET-1), and fibroblast growth factor 2 (FGF2)...
  61. Anti-angiogenesis of HC-HA Covalent Complex and PTX3 Purified from Fetal Membrane
    Scheffer C G Tseng; Fiscal Year: 2011
    ..to HC"HA to produce a new class of angiogenesis inhibitors, which will not only suppress angiogenesis mediated by bFGF and VEGF but will also be more useful and effective by curtailing additional inflammation and scarring...
  62. SIGNALING MECHANISMS IN REGULATION OF TUMOR ANGIOGENESIS
    DOMINIC E COSGROVE; Fiscal Year: 2012
    ..of many types of cancers is associated with up-regulation of several proangiogenic factors (HIF- 1a, VEGF, bFGF, PDGF, and MMP's etc.) which promotes tumor angiogenesis...
  63. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..
  64. Monoclonal Antibody to FGF Receptor 2 for Treatment of Gastric and Other Cancers
    K Jin Kim; Fiscal Year: 2009
    ..The antibody will have the potential to be an effective drug for various types of cancer including gastric, pancreatic, breast, ovarian and uterine. ..
  65. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..Morphometric and immunocytochemical analyses will include areas where FGF1 and FGF2 are jointly expressed during development. ..
  66. ROLE OF FIBROBLAST GROWTH FACTORS IN PROSTATE GROWTH
    Michael Ittmann; Fiscal Year: 2003
    ..Their final goal is to define the role of FGF 17 as an epithelial derived paracrine inducer of stromal cell proliferation. ..
  67. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    Regina C Armstrong; Fiscal Year: 2010
    ..These findings can then direct repair strategies that may be a valuable complement to strategies that abrogate myelin damage in MS and other demyelinating diseases. ..