FCGR2B

Summary

Gene Symbol: FCGR2B
Description: Fc fragment of IgG receptor IIb
Alias: CD32, CD32B, FCG2, FCGR2, IGFR2, low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc fragment of IgG, low affinity II, receptor for (CD32), Fc fragment of IgG, low affinity IIb, receptor (CD32), Fc fragment of IgG, low affinity IIb, receptor for (CD32), Fc gamma RIIb, Fc gamma receptor IIb, fc-gamma RII-b, fc-gamma-RIIb, fcRII-b, igG Fc receptor II-b
Species: human

Top Publications

  1. ncbi Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses
    P A Warmerdam
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Int Immunol 5:239-47. 1993
  2. ncbi A regulatory role for Fc gamma receptors (CD16 and CD32) in hematopoiesis
    B de Andres
    Department of Pathology, The University of Iowa College of Medicine, Iowa City 52242, USA
    Immunol Lett 68:109-13. 1999
  3. ncbi Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines
    L Pricop
    Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 166:531-7. 2001
  4. ncbi Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais
    U Siriboonrit
    Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Tissue Antigens 61:374-83. 2003
  5. pmc Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution
    P Sondermann
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 18:1095-103. 1999
  6. ncbi The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus
    Mikhail Olferiev
    Hospital for Special Surgery, Research Division, New York, USA
    J Biol Chem 282:1738-46. 2007
  7. ncbi A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1
    D N Burshtyn
    Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 272:13066-72. 1997
  8. pmc Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen
    L Ding
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20851 1448, USA
    Immunology 104:28-36. 2001
  9. ncbi Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Clin Immunol 122:338-42. 2007
  10. ncbi Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination
    W Q Qiu
    Division of Molecular Biology, Sloan Kettering Institute, New York, NY 10021
    Science 248:732-5. 1990

Detail Information

Publications233 found, 100 shown here

  1. ncbi Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses
    P A Warmerdam
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Int Immunol 5:239-47. 1993
    A group of Fc receptor molecules, classified CD32, recognize the Fc moiety of IgG with low affinity...
  2. ncbi A regulatory role for Fc gamma receptors (CD16 and CD32) in hematopoiesis
    B de Andres
    Department of Pathology, The University of Iowa College of Medicine, Iowa City 52242, USA
    Immunol Lett 68:109-13. 1999
    Progenitor cells of the T- and B-lineages in mice express (CD32) and Fc gamma RIII (CD16) but as the developing lymphocytes begin to express clonal antigen receptors, CD16 and CD32 are downregulated in T-cells, and CD16 is downregulated ..
  3. ncbi Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines
    L Pricop
    Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 166:531-7. 2001
    ....
  4. ncbi Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais
    U Siriboonrit
    Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Tissue Antigens 61:374-83. 2003
    ..These results provided evidence that FcgammaR polymorphisms may be an important predisposing factor also in Thais in a complex manner...
  5. pmc Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution
    P Sondermann
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 18:1095-103. 1999
    ....
  6. ncbi The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus
    Mikhail Olferiev
    Hospital for Special Surgery, Research Division, New York, USA
    J Biol Chem 282:1738-46. 2007
    ..The -343 G --> C polymorphism in the human FCGR2B promoter is associated with systemic lupus erythematosus...
  7. ncbi A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1
    D N Burshtyn
    Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 272:13066-72. 1997
    ..The contribution of a hydrophobic amino acid two residues upstream of the tyrosine in the SHP-1-binding motif may be an important feature that distinguishes inhibitory receptors from those that provide activation signals...
  8. pmc Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen
    L Ding
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20851 1448, USA
    Immunology 104:28-36. 2001
    ....
  9. ncbi Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Clin Immunol 122:338-42. 2007
    ....
  10. ncbi Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination
    W Q Qiu
    Division of Molecular Biology, Sloan Kettering Institute, New York, NY 10021
    Science 248:732-5. 1990
    ..Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus...
  11. pmc In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation
    N Bewarder
    Biochemie II, Fakultat fur Chemie, Universitat Bielefeld, Germany
    Mol Cell Biol 16:4735-43. 1996
    ..Comparison of the phosphorylation pattern of each PTK observed in vitro with the phosphorylation pattern observed in vivo suggests that Lyn is the most likely candidate for FcgammaRIIa/c and FcgammaRIIb1 phosphorylation in vivo...
  12. ncbi Studies on the association of Fc gamma receptor IIA, IIB, IIIA and IIIB polymorphisms with rheumatoid arthritis in the Japanese: evidence for a genetic interaction between HLA-DRB1 and FCGR3A
    C Kyogoku
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Genes Immun 3:488-93. 2002
    ..This study was performed to examine whether FCGR2B-I232T was associated with susceptibility to rheumatoid arthritis in the Japanese...
  13. ncbi Evidence for non-random distribution of Fcgamma receptor genotype combinations
    W Ludo van der Pol
    Department of Immunology, Laboratory for Immunotherapy, KC 02 085 2, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Immunogenetics 55:240-6. 2003
    ..00001). This study provides important information for the interpretation of studies reporting associations of FcgammaR alleles with disease, and underscores the apparent differences in FcgammaR heterogeneity between ethnic groups...
  14. ncbi Polymorphisms of the Fc gamma receptor type IIB gene are not associated with systemic lupus erythematosus in the Swedish population
    V Magnusson
    University of Uppsala, Uppsala, Sweden
    Arthritis Rheum 50:1348-50. 2004
  15. ncbi Platelet count, previous infection and FCGR2B genotype predict development of chronic disease in newly diagnosed idiopathic thrombocytopenia in childhood: results of a prospective study
    Marrie Bruin
    University Children s Hospital The Wilhelmina Children s Hospital, University Medical Centre, Utrecht, The Netherlands
    Br J Haematol 127:561-7. 2004
    ..57) and FGR2B-232I/T genotype (OR 7.9, CI 0.96-65.27). The latter may point at an immune-modulating role of Fc gamma RIIb in ITP...
  16. ncbi Molecular analysis of expression and function of hFcgammaRIIbl and b2 isoforms in myeloid cells
    Trupti Joshi
    The Ohio State University Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Mol Immunol 43:839-50. 2006
    ..Finally, both b1 and b2 isoforms of FcgammaRIIb downregulate phagocytosis to a similar extent. Thus we conclude that FcgammaRIIbl and b2 are both functional inhibitory receptors in the phagocytic process...
  17. ncbi FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling
    Hajime Kono
    Department of Allergy and Rheumatology, Faculty of Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Hum Mol Genet 14:2881-92. 2005
    ..We have identified a polymorphism FCGR2B c...
  18. ncbi Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts
    R Andres Floto
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge CB2 2XY, UK
    Nat Med 11:1056-8. 2005
    ..FcgammaRIIbT(232) is unable to inhibit activatory receptors because it is excluded from sphingolipid rafts, resulting in the unopposed proinflammatory signaling thought to promote SLE...
  19. ncbi Association of Fcgamma receptor IIB gene polymorphism with genetic susceptibility to systemic lupus erythematosus in Chinese populations--a family-based association study
    Faming Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 69 Meishan Road, Hefei, Anhui 230032, China
    J Dermatol Sci 43:35-41. 2006
    ....
  20. pmc Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE
    Meggan Mackay
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Exp Med 203:2157-64. 2006
    ....
  21. ncbi Capture of flowing human neutrophils by immobilised immunoglobulin: roles of Fc-receptors CD16 and CD32
    Christopher A Skilbeck
    Department of Physiology, The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
    Cell Immunol 241:26-31. 2006
    ..and activation of flowing human neutrophils through their Fc-receptors, FcRgammaIIIB (CD16) and FcRgammaIIA (CD32)...
  22. ncbi The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 54:3828-37. 2006
    ..The purpose of this study was to unravel the role of the inhibitory FcgammaRIIb in rheumatoid arthritis (RA) by studying the effect of the FCGR2B 695T>C polymorphism on susceptibility to RA, severity of the disease, and DC function.
  23. ncbi Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
    Ji Yih Chen
    Department of Medicine, Chang Gung Memorial Hospital, Taiwan, Republic of China
    Arthritis Rheum 54:3908-17. 2006
    ....
  24. pmc Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria
    Menna R Clatworthy
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 104:7169-74. 2007
    ....
  25. pmc High synovial expression of the inhibitory FcgammaRIIb in rheumatoid arthritis
    Sofia E Magnusson
    Department of Cell and Molecular Biology, Programme for Molecular Immunology, Uppsala University, Husargatan 3, Uppsala, 751 24, Sweden
    Arthritis Res Ther 9:R51. 2007
    ..Anti-inflammatory drugs that target activating FcgammaRs may represent valuable therapeutics in this disease...
  26. pmc A transmembrane polymorphism in FcgammaRIIb (FCGR2B) is associated with the production of anti-cyclic citrullinated peptide autoantibodies in Taiwanese RA
    J Y Chen
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao Yuan, Taiwan, Republic of China
    Genes Immun 9:680-8. 2008
    ..038 (95% CI 1.046-3.973)) and the 187-Ile allele was associated with early-onset of RA in Taiwanese patients (P=0.045, OR 1.548 (95% CI 1.007-2.379)). Thus, FcgammaRIIb SNP 187-Ile/Thr may influence the RA phenotypes in Taiwanese RA...
  27. doi Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B
    Willemijn B Breunis
    Department of Pediatric Hematology, Immunology and Infectious Disease at Emma Children s Hospital, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
    Hum Mutat 30:E640-50. 2009
    ..No CNV of the FCGR2A and FCGR2B genes was observed in over 600 individuals...
  28. doi FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese
    Xu Jie Zhou
    Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, People s Republic of China
    Nephrol Dial Transplant 25:97-101. 2010
    ..We aimed to clarify the genetic association of FCGR gene polymorphisms with anti-GBM disease in Chinese patients...
  29. doi The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease
    Mark H Wenink
    Department of Rheumatology, Nijmegen Centre of Molecular Life Sciences and Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, The Netherlands
    J Immunol 183:4509-20. 2009
    ..This TLR4-FcgammaRIIb interaction was shown to dependent on the PI3K and Akt pathway...
  30. doi Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease
    Xu Jie Zhou
    Renal Division, Peking University First Hospital, Peking University Institute of Nephrology and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, People s Republic of China
    Int Immunol 22:45-51. 2010
    ..Here, we investigated CNV of three FCGR genes, including two (FCGR3A and FCGR3B) for activating FcgammaRs and one (FCGR2B) for inhibitory FcgammaR by duplex quantitative real-time PCR...
  31. pmc A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus
    Lisa C Willcocks
    Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 107:7881-5. 2010
    ..We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and ..
  32. doi SNPs of Fc-gamma receptor genes and chronic periodontitis
    L Chai
    Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China
    J Dent Res 89:705-10. 2010
    ..003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese...
  33. pmc Copy number, linkage disequilibrium and disease association in the FCGR locus
    Heather A Niederer
    Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    Hum Mol Genet 19:3282-94. 2010
    ..Thus CN of FCGR3B, which controls IC responses and uptake by neutrophils, and variations in FCGR2B, which controls factors such as antibody production and macrophage activation, are important in SLE pathogenesis...
  34. pmc Association of Fcγ receptor IIB polymorphism with cryptococcal meningitis in HIV-uninfected Chinese patients
    Xiu Ping Hu
    Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 7:e42439. 2012
    ..The aim of the present study was to identify the association between FCGR polymorphisms and cryptococcal meningitis...
  35. ncbi Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility
    Chieko Kyogoku
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 46:1242-54. 2002
    ..examine the possibility that another susceptibility gene of primary significance exists within the FcgammaR region, we screened for polymorphisms of the human FCGR2B gene, and examined whether these polymorphisms are associated with SLE.
  36. ncbi A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling
    Xiaoli Li
    University of Alabama at Birmingham, AL 35294 0006, USA
    Arthritis Rheum 48:3242-52. 2003
    ..The transmembrane domain of FcgammaRIIb may also contribute to receptor signaling. Therefore, we investigated the biologic significance of single-nucleotide polymorphisms (SNPs) throughout the coding region...
  37. ncbi Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations
    Z T Chu
    Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, China
    Tissue Antigens 63:21-7. 2004
    ..recently identified a single-nucleotide polymorphism encoding a non-synonymous substitution, Ile232Thr (I232T), of FCGR2B and its association with SLE in Japanese and in Thais...
  38. ncbi A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus
    Kaihong Su
    Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 172:7186-91. 2004
    ..We have identified 10 novel single-nucleotide polymorphisms in the promoter region of human FCGR2B gene and characterized two functionally distinct haplotypes in its proximal promoter...
  39. pmc Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes
    D G Brooks
    DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
    J Exp Med 170:1369-85. 1989
    ..A minimum of three genes (Fc gamma RIIa, IIa', and Fc gamma RIIb) encode these transcripts, which demonstrate highly related extracellular and membrane spanning domains...
  40. ncbi Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy
    T Valerius
    Department of Medicine III, University of Erlangen Nurnberg, Germany
    Blood 82:931-9. 1993
    ..of which polymorphonuclear phagocytes (PMN) normally express both low-affinity receptor classes--Fc gamma RII (CD32) and Fc gamma RIII (CD16)...
  41. pmc Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI
    B Wang
    Department of Dermatology I, University of Vienna Medical School, Austria
    J Exp Med 175:1353-65. 1992
    ..by preincubation of the tissue with monoclonal antibodies (mAb) against either Fc epsilon RII/CD23 or Fc gamma RII/CD32, nor by the addition of lactose...
  42. ncbi Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32)
    S Werwitzke
    Department of Clinical Immunology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Ann Rheum Dis 67:154-61. 2008
    ..Moreover, soluble Fc gamma Rs inhibit IC-caused Arthus reaction in vivo. Therefore, recombinant human soluble Fc gamma RII (CD32) was evaluated as a novel therapeutic strategy in lupus-like disease in NZB/NZW F(1) hybrids.
  43. ncbi Evidence that human Fc gamma receptor IIA (CD32) subtypes are not receptors for oxidized LDL
    P M Morganelli
    Veterans Administration Hospital, White River Junction, VT 05009, USA
    Arterioscler Thromb Vasc Biol 17:3248-54. 1997
    ..In humans, the homologous Fc gamma R is Fc gamma RIIA (CD32), which is abundantly expressed on monocytes and macrophages and shares 60% sequence identity with murine Fc gamma ..
  44. ncbi Beta 2-adrenoceptor stimulation augments the IL-4-induced CD23 expression and release and the expression of differentiation markers (CD14, CD18) by the human monocytic cell line, U 937
    N Paul-Eugene
    Laboratoire d Immuno Allergologie, Institut Henri Beaufour, Les Ulis, France
    Clin Exp Allergy 23:317-25. 1993
    ..Salbutamol down-regulated the expression of Fc gamma RI (CD64) and Fc gamma RII (CD32) whereas IL-4 was ineffective...
  45. ncbi Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors
    Carolyn Mold
    Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico, Albuquerque, NM 87108, USA
    J Immunol 168:6375-81. 2002
    ..Injection of CRP protected wild-type, FcR gamma-chain-, Fc gamma RIIb-, and Fc gamma RIII-deficient mice from infection...
  46. ncbi Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases
    Andrew Saxon
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1680, USA
    Curr Opin Allergy Clin Immunol 4:563-8. 2004
    ....
  47. pmc Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent
    Dongqi Xing
    Vascular Biology and Hypertension Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Pathol 172:22-30. 2008
    ..OVX NTG, CRPtg, and CRPtg lacking Fc gamma RI, Fc gamma RIIb, Fc gamma RIII, or the common gamma chain (FcR gamma) had their common carotid artery ligated...
  48. ncbi Regulation of signal transduction by the Fc gamma receptor family members and their involvement in autoimmunity
    K Mark Coggeshall
    Program in Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, Okla, USA
    Curr Dir Autoimmun 5:1-29. 2002
    ..A number of recent findings reveal that such cells express inhibitory receptors, including the elusive CD32/Fc gamma RIIB isoform, and express inhibitory phosphatases like SHP-1 and SHIP...
  49. doi Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages
    Tomohiro Arikawa
    Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Clin Immunol 133:382-92. 2009
    Galectin-9 up-regulated Fc gamma RIIb expression of mouse peritoneal macrophages in vitro but down-regulated Fc gamma RIII expression...
  50. ncbi Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response
    D Qin
    Department of Microbiology and Immunology and Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    J Immunol 164:6268-75. 2000
    ..FDCs in GCs, but not in primary follicles, express high levels of the IgG Fc receptor Fc gamma RIIB. This regulated expression of Fc gamma RIIB on FDC and its relation to recall Ab responses were examined both ..
  51. ncbi IgG and complement receptor expression in children treated by peritoneal dialysis
    Antonia H M Bouts
    Emma Children s Hospital AMC, University of Amsterdam, The Netherlands
    Pediatr Nephrol 20:1161-7. 2005
    ..WBCs were isolated from blood and PDE, labelled with FITC-conjugated CD16 (FcgammaRIII), CD32 (FcgammaRII), CD64 (FcgammaRI), CD11b (CR3) and CD35 (CR1) monoclonal antibodies, and analysed by flow cytometry...
  52. ncbi Early changes in murine epidermal cell phenotype by contact sensitizers
    K D Coutant
    Novartis Pharma, Preclinical Safety, Toxicology Pathology, Basel, Switzerland
    Toxicol Sci 48:74-81. 1999
    ..with the strong contact sensitizer, TNBS, Langerhans cells (LCs) demonstrated a rapid up-regulation of CD45, CD40, CD32/16 (Fc gamma RII/III) and CD23 (Fc epsilon RII) molecules...
  53. ncbi Macrophages activated by C-reactive protein through Fc gamma RI transfer suppression of immune thrombocytopenia
    Kristopher D Marjon
    University of New Mexico, Albuquerque, NM 87108, USA
    J Immunol 182:1397-403. 2009
    ..Suppression of ITP by CRP-treated splenocytes required Fc gamma RI on the donor cell and Fc gamma RIIb in the recipient mice...
  54. ncbi Analysis of factors contributing to the formation of mononuclear cell aggregates ("escapees") in flow cytometric immunophenotyping
    J W Gratama
    Department of Clinical and Tumor Immunology, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Cytometry 29:250-60. 1997
    ..Platelets, monocytes, and granulocytes express the polymorphic class IIa IgG receptor (Fc gammaRIIa; CD32)...
  55. ncbi Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors
    T Nishimura
    Laboratory of Immunoregulation, Department of Immunology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Int Immunol 13:1075-84. 2001
    ..We report here the characterization of the promoter structure of the human Fc gamma RIIB gene and the isolation of the promoter region-binding proteins by a yeast one-hybrid assay...
  56. ncbi Expression of activated Fc gamma RII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects
    Deon Kanters
    Department of Pulmonary Diseases, University Medical Center Utrecht UMCU, Utrecht, The Netherlands
    J Allergy Clin Immunol 120:1073-81. 2007
    ..Systemic responses include priming of peripheral blood eosinophils, which is enhanced after allergen challenge. In a subpopulation of asthmatic subjects, neutrophils are associated with bronchial inflammation...
  57. ncbi Change in expression of Fc gamma RIII (CD16) on neutrophils from human immunodeficiency virus-infected individuals
    P Boros
    Department of Biochemistry, Mount Sinai Medical School, New York City, New York 10029
    Clin Immunol Immunopathol 54:281-9. 1990
    ..We have examined the expression of Fc gamma RIII (CD16), CD11b, and Fc gamma RII (CD32) on neutrophils from human immunodeficiency virus (HIV)-I-infected individuals by two-color FACS...
  58. ncbi Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis
    Ranhy Bang
    Department of Veterans Affairs Medical Center and The University of New Mexico, School of Medicine, Albuquerque, New Mexico 87108, USA
    J Biol Chem 280:25095-102. 2005
    ..to elucidate amino acid residues important for the interaction of CRP with human FcgammaRI (CD64) and FcgammaRIIa (CD32). Several mutations of the CRP structure were studied based on the published crystal structure of CRP...
  59. ncbi Detection of anti-CD32 alloantibody in donor plasma implicated in development of transfusion-related acute lung injury
    Motoko Nishimura
    Research Section, Tokyo Metropolitan Red Cross Blood Center, 4 1 31 Hiro o, Tokyo 150 0012, Japan
    Cell Biochem Funct 25:179-83. 2007
    ..Anti-CD32 (Fc gamma RIII) alloantibodies were detected in all the plasma samples using two different clones of the monoclonal ..
  60. ncbi Engineering therapeutic antibodies for improved function
    L G Presta
    Genentech, Inc, South San Francisco, CA 94080, USA
    Biochem Soc Trans 30:487-90. 2002
    The binding sites on human IgG1 for human Fc gamma receptor (Fc gamma R) I, Fc gamma RIIa, Fc gamma RIIb, Fc gamma RIIIa and neonatal FcR have been mapped...
  61. ncbi Fc receptor-mediated immunity against Bordetella pertussis
    M E Rodriguez
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 167:6545-51. 2001
    ..This process was mediated by the PMN IgG receptors, FcgammaRIIa (CD32) and FcgammaRIIIb (CD16), working synergistically...
  62. pmc A role for complement in feedback enhancement of antibody responses by IgG3
    Teresita Díaz de Ståhl
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    J Exp Med 197:1183-90. 2003
    ..FcR gamma -/-), resulting in reduced expression of Fc gamma RI and lack of Fc gamma RIII, and mice lacking Fc gamma RIIB (Fc gamma RIIB-/-), responded equally well to immunization with IgG3-complexed Ag as wild-type controls...
  63. ncbi Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease
    Pierre Bruhns
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Immunity 18:573-81. 2003
    The ability of IVIG to induce expression of Fc gamma RIIB and thereby prevent antibody-induced inflammation has been used as a probe to dissect the effector cell components in the KRNxNOD (K/BxN) arthritis model...
  64. ncbi Heparin-induced thrombocytopenia
    F Fabris
    Istituto di Semeiotica Medica, Via Ospedale 105, 35100 Padua, Italy
    Haematologica 85:72-81. 2000
    ..The aim of this article is to review the most recent advances in the field and to give critical guidelines for the clinical diagnosis and treatment of HIT II...
  65. ncbi Reactivity of monoclonal antibodies to human CD antigens with cells from mink
    B Aasted
    Department of Veterinary Pathobiology, Immunological Laboratory, Faculty of Life Sciences, University of Copenhagen, Stigbojlen 7, DK 1870 Frederiksberg C, Copenhagen, Denmark
    Vet Immunol Immunopathol 119:27-37. 2007
    ..2 mAbs), CD14 (3 mAbs), CD18 (5 mAbs), CD20 (atypical reaction), CD21, CD25 (atypical reaction), CD29 (3 mAbs), CD32, CD41, CD42a, CD44 (4 mAbs), CD45, CD45RO, CD47 (2 mAbs), CD49d (3 mAbs), CD61 (2 mAbs), CD62P, CD66abcd, CD71, ..
  66. ncbi Phagocytosis and intracellular killing of serum-opsonized Staphylococcus aureus by mouse fibroblasts expressing human Fcgamma receptor type IIa (CD32)
    P H Nibbering
    Dept of Infectious Diseases, University Hospital, Leiden, The Netherlands
    Front Biosci 1:a25-33. 1996
    ..Taken together, these data show that phagocytosis but not intracellular killing of S. aureus is mediated via FcgammaRIIa on cells expressing this receptor...
  67. doi Expression of complement receptor 2 (CD21), membrane IgM and the inhibitory receptor CD32 (FcgammaRIIb) in the lymphoid tissues of neonatal calves
    Kuldeep S Chattha
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Vet Immunol Immunopathol 137:99-108. 2010
    ..The inhibitory receptor CD32 (FcgammaRII) when co-ligated with mIgM by antigen-antibody complexes raises the threshold for activation...
  68. ncbi Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies
    M Ghannadan
    Department of Internal Medicine I, University of Vienna, Austria
    J Invest Dermatol 111:689-95. 1998
    ..Also, cutaneous MC (from both juvenile foreskin and adult mammary skin), but not lung MC, were found to bind the CD32 MoAb IV.3, 2E1, and FLI8.26 (Fc gammaRII)...
  69. ncbi Cross-reaction of anti-human CD monoclonal antibodies on guinea pig cells: a summary of the guinea pig section of the HLDA8 animal homologues data
    Todd M Lasco
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Vet Immunol Immunopathol 119:131-6. 2007
    ..Our results indicate that 15 anti-human CD9, CD10, CD14, CD20 (two clones), CD22, CD25, CD29 (two clones), CD32, CD47 (two clones), CD49d, CD49e, and CD86 mAbs exhibit clear cross-reactivity with guinea pig splenocytes...
  70. ncbi Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects
    R Castelli
    Department of Medicine and Medical Specialities Division of Internal Medicine, IRCCS Fondazione Ospedale Maggiore Policlinico of Milan, Via Pace 9 Milan, Italy
    Cardiovasc Hematol Disord Drug Targets 7:153-62. 2007
    ..The anti-heparin/PF4 IgG immune-complexes activates platelets through binding with the Fcgamma RIIa (CD32) receptor inducing endothelial lesions with thrombocytopenia and thrombosis...
  71. ncbi Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH
    Odette de Bouteiller
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, 69571 Dardilly Cedex, France
    J Biol Chem 280:38133-45. 2005
    ..Expression of TLR3-CD32 in HEK293T cells and the myeloid cell line U937 resulted in surface localization of the receptor, whereas the ..
  72. pmc Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32)
    W W Shanaka I Rodrigo
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Crittenden Avenue, Rochester, NY 14642, USA
    J Virol 80:10128-38. 2006
    ..FcgammaRIA (CD64) and FcgammaRIIA (CD32), which predominate on the surface of such dengue virus-permissive cells, were compared for their influence on the ..
  73. pmc Maternal immunization with ovalbumin prevents neonatal allergy development and up-regulates inhibitory receptor Fc gamma RIIB expression on B cells
    Jefferson R Victor
    Laboratory of Dermatology and Immunodeficiencies, School of Medicine, University of Sao Paulo, LIM 56, Sao Paulo, Brazil
    BMC Immunol 11:11. 2010
    ....
  74. pmc Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus
    Yi Li
    Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0221, USA
    Arthritis Res Ther 11:R6. 2009
    ..The goal of this study was to determine whether expression of Fc receptor (FcgammaR) I on circulating monocytes is associated with systemic inflammation and renal disease in SLE patients...
  75. ncbi Antigenic profile of human thymus in concurrence with "Clusters of Thymic Epithelial Staining" classification
    F Figen Kaymaz
    Department of Histology and Embryology, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
    Ann Anat 185:163-71. 2003
    ..for various monoclonal antibodies recognizing CD antigens (CD1, CD1a, CD6, CD9, CD14, CD16, CD29, CD30, CD32, CD44, CD45RB, CD47, CD48, CD49a, CD49b, CD49c, CD49d, CD49e, CD49f, CD51, CD53, CD54, CD56, CD57, CD63, CD85, CD95,..
  76. doi T cell responses to steroid cytochrome P450 21-hydroxylase in patients with autoimmune primary adrenal insufficiency
    Eirik Bratland
    Department of Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
    J Clin Endocrinol Metab 94:5117-24. 2009
    ..Autoantibodies against the steroidogenic cytochrome P450 enzyme 21-hydroxylase (21OH) are found in most patients, and 21OH is therefore a likely target for antigen-specific T cells...
  77. ncbi Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells
    Zhihua Kou
    Department of Medicine, Infectious Diseases Division, University of Rochester, Rochester, New York 14642, USA
    J Med Virol 80:134-46. 2008
    ..detection of infected cells, and the addition of monoclonal antibodies to either FcgammaRI (CD64) or FcgammaRII (CD32) led to a 50-70% reduction in antibody-dependent enhancement (ADE) of DV infection...
  78. doi Intravenous immunoglobulins induce CD32-mediated platelet aggregation in vitro
    A Pollreisz
    Department of Surgery, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Br J Dermatol 159:578-84. 2008
    ..In a previous study we have shown that rabbit antithymocyte globulin causes platelet aggregation in vitro via the Fc IgG receptor (CD32).
  79. ncbi Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3
    V Kindler
    Division of Hematology, Geneva University Hospital, Switzerland
    J Immunol 159:2085-90. 1997
    ..In vitro, human B cell activation has been investigated extensively by coculturing tonsillar B cells with CD32-transfected fibroblasts coated with anti-CD40 Abs, in the presence of cytokines (the CD40 system)...
  80. ncbi Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle
    Takashi Saito
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, Yokohama, Japan
    Zoolog Sci 20:441-7. 2003
    ..rat masseter muscle during the shift of rat feeding behavior, we analyzed the expressions of IGF-I, IGF-II, IGFR1, IGFR2, and IGFBP1~6 mRNAs in rat masseter muscle between 0 and 70 days after birth using the competitive, reverse ..
  81. ncbi IGG and complement receptor expression on peripheral white blood cells in uraemic children
    Antonia H M Bouts
    Emma Children s Hospital, G8 218, Academic Medical Center, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Nephrol Dial Transplant 19:2296-301. 2004
    ..We measured the effect of uraemia and dialysis treatment on FcgammaR and CR expression on leukocytes in blood...
  82. pmc Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus
    Kaihong Su
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 178:3272-80. 2007
    ..and lymphoid cells is regulated by the naturally occurring regulatory single nucleotide polymorphisms in the FCGR2B promoter...
  83. pmc Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion
    Zhihua Xiao
    Chemical and Biological Engineering, State University of New York, Buffalo, NY 14260, USA
    Blood 112:1091-100. 2008
    ..Cell activation was inhibited by both chondroitinase ABC and anti-CD32/FcgammaRII blocking mAb, IV.3. Confocal microscopy demonstrated that immune complexes colocalize with CD32a...
  84. pmc Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3
    Karl R Karlsson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Exp Hematol 36:1167-75. 2008
    ..To develop a simple and efficient method for producing homogeneous populations of monocytes and macrophages from human embryonic stem cells (hES)...
  85. ncbi The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein
    D Simmons
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Nature 333:568-70. 1988
    ..been described; FcRI, a high-affinity (Ka approximately equal to 10(8) M-1) receptor expressed on monocytes; FcRII (CD32), a low-affinity (Ka approximately equal to 10(6) M-1) receptor expressed on B cells, granulocytes, macrophages and ..
  86. pmc Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice
    J Wang
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Exp Med 184:831-8. 1996
    ..with control B cells, Lyn-/- B cells were hyper responsive to anti-IgM-induced proliferation and defective in Fc gamma RIIB-mediated suppression of B cell antigen receptor (BCR) signaling, indicating that Lyn is involved in the ..
  87. pmc Expression of Fc gamma and complement receptors in monocytes of X-linked agammaglobulinaemia and common variable immunodeficiency patients
    A L B Amoras
    Center for Investigation in Pediatrics, Department of Pediatrics, State University of Campinas Medical School, Campinas, SP, Brazil
    Clin Exp Immunol 150:422-8. 2007
    ..Surface expression of Fc gammaRI (CD64), Fc gammaRII (CD32) and Fc gammaRIII (CD16), CR1 (CD35) and CR3 (CD11b and CD18) was measured by determination of the proportion of ..
  88. ncbi An IgM class anti-neutrophil cytoplasm antibody inhibits neutrophil adhesion and apoptosis via a Syk dependent signaling cascade
    M J Hayes
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Mol Immunol 41:457-68. 2004
    ..this antibody they are readily phagocytosed by macrophages and we show that 'blocking' antibodies to FcgammaRIIa (CD32) on the macrophage inhibit this process...
  89. ncbi B-cell subsets in blood and lymphoid organs in Macaca fascicularis
    Y Vugmeyster
    Bioanalytical Research and Development, Genentech Inc, South San Francisco, California, USA
    Cytometry A 61:69-75. 2004
    ..Cynomolgus monkeys (Macaca fascicularis) are widely used animal models in biomedical research. However, the phenotypic characteristics of cynomolgus monkey (CM) B cells in peripheral blood (PB) and lymphoid organs are poorly understood...
  90. pmc Comparison of sample fixation and the use of LDS-751 or anti-CD45 for leukocyte identification in mouse whole blood for flow cytometry
    Melissa L Maes
    College of Nursing, The University of Arizona, Tucson, Arizona 85724, USA
    J Immunol Methods 319:79-86. 2007
    ..Samples were incubated with CD16/CD32 Fc receptor blocker, and either 10 microg/ml LDS-751 or phosphate buffered saline (PBS)...
  91. ncbi The retinol acid receptor B gene is hypermethylated in patients with familial partial lipodystrophy
    Rene Cortese
    Epigenomics AG Berlin, Berlin, Germany
    J Mol Endocrinol 38:663-71. 2007
    ..genes related to fat metabolism, aging, and a tendency to different methylation patterns: CSPG2, ESR1, IGF1R, IGFR2, LMNA, MLH1, RANBP1, RARB, ZMPSTE24, and TGFBR1...
  92. ncbi An FcgammaRIIa-binding peptide that mimics the interaction between FcgammaRIIa and IgG
    Angela C Cendron
    Burnet Institute, Austin Campus, Studley Road, Heidelberg, VIC 3084, Australia
    Mol Immunol 45:307-19. 2008
    A disulphide-constrained peptide that binds to the low affinity Fc receptor, FcgammaRIIa (CD32) has been identified and its structure solved by NMR...
  93. ncbi Expression cloning of complementary DNA encoding three distinct isoforms of guinea pig Fc receptor for IgG1 and IgG2
    T Yamashita
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
    J Immunol 151:2014-23. 1993
    ..gamma 1/gamma 2R-B1, is identical to the previously isolated cDNA clone homologous to the b2 isoform of human Fc gamma RIIB and that of murine Fc gamma RII, encoding a transmembrane glycoprotein containing two Ig-like extracellular ..
  94. pmc Regulation and targeting of T-cell immune responses by IgE and IgG antibodies
    R Bheekha Escura
    Department of Immuno Dermatology, Sandoz Research Institute, Vienna, Austria
    Immunology 86:343-50. 1995
    ..of various Der pI/IgG ratios failed to bind significantly to the Fc receptor for IgG on B cells (Fc gamma RII; CD32)...
  95. ncbi Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell
    G Sarmay
    Department of Immunology, Lorand Eotvos University, God, Hungary
    Immunol Lett 57:159-64. 1997
    Co-clustering of Fc gamma RIIb and B-cell receptor (BCR) inhibits cell activation by interrupting BCR stimulated signal transduction...
  96. ncbi Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship
    P Stanier
    Division of Paediatrics, Obstetrics and Gynaecology, Queen Charlotte s and Chelsea Hospital, Goldhawk Road, London, W6 OXG, United Kingdom
    Genomics 51:144-7. 1998
    ..The localization of Tagln2 was also determined and was found to map between Fcgr2 and D1Mit149 on distal mouse chromosome 1...
  97. ncbi Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1
    R Lesourne
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U 255, Institut Curie, 75005 Paris, France
    J Biol Chem 276:6327-36. 2001
    b>Fc gamma RIIB are IgG receptors that inhibit immunoreceptor tyrosine-based activation motif (ITAM)-dependent cell activation...
  98. ncbi Differentiation of regulatory T cells 1 is induced by CD2 costimulation
    A Wakkach
    Institut National de la Santé et de la Recherche Médicale Unité 343, Hopital de l Archet, Nice, France
    J Immunol 167:3107-13. 2001
    ..both high IL-10 secretion and regulatory function were observed after the first stimulation of naive T cells with CD32-CD58 L cells...
  99. ncbi Antidisialoganglioside/granulocyte macrophage-colony-stimulating factor fusion protein facilitates neutrophil antibody-dependent cellular cytotoxicity and depends on FcgammaRII (CD32) and Mac-1 (CD11b/CD18) for enhanced effector cell adhesion and azurophi
    Leonid S Metelitsa
    Department of Pediatrics, Division of Hematology Oncology, Children s Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles 90027, USA
    Blood 99:4166-73. 2002
    ..Thus, hu14.18/GM-CSF facilitates PMN ADCC against neuroblastoma cells associated with FcgammaRII and Mac-1-dependent enhanced adhesion and degranulation...
  100. ncbi Expression of Fcgamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis
    A L Hepburn
    Rheumatology Section, Faculty of Medicine, Imperial College London, Hammersmith Hospital, UK
    Rheumatology (Oxford) 43:547-54. 2004
    ..However, little data exist on the in vivo expression of specific Fcgamma and complement receptors in systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), two diseases in which IC are important in pathogenesis...
  101. ncbi A novel method for simultaneous analysis of specific platelet antibodies: SASPA
    Xuan Duc Nguyen
    Institute of Transfusion Medicine and Immunology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Red Cross Blood Service of Baden Württemberg Hessen, 68167 Mannheim, Germany
    Br J Haematol 127:552-60. 2004
    ..the simultaneous immobilization of platelet-GP [IIb/IIIa, Ib/IX, human leucocyte antigen (HLA) class I, or Ia/IIa, CD32, GPIV or CD109, Ib/IX, HLA class I]...

Research Grants57

  1. Development of Soluble FcR-Ig Fusion Proteins
    Leslie Johnson; Fiscal Year: 2004
    ..aims of this project are the generation of novel sFcR-Ig molecules based on FcgammaRIII (CD16) FcgammaRIIb (CD32b) and FcgammaRIla (CD32a) and the evaluation of these proteins in vitro and in animal models of autoimmune ..
  2. Role of anti-Fc Gamma RIIB antibody in tumor clearance
    CHRISTOPHER RANKIN; Fiscal Year: 2004
    ..A successful study could therefore impact on and benefit a large numbers of cancer patients in the future. ..
  3. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2005
    ..has a dual objective: to elucidate the structure-function relationship of two low-affinity Fc-gamma-Rs (CD16 and CD32) and to use these as a model system to address fundamental issues in the biophysics of cell adhesion...
  4. C-Reactive Protein Regulation of the Interferon Response in SLE
    Carolyn Mold; Fiscal Year: 2010
    ..CRP levels increase the activation threshold of monocytes and dendritic cells (DC) by increasing expression Fc gamma RIIb, an inhibitory receptor. This then limits innate responses that promote autoimmunity...
  5. Philip W Shaul; Fiscal Year: 2016
    ..Unique preventative or treatment measures to combat the HTN that complicates obesity and other chronic inflammatory conditions will potentially follow. ..
  6. FcgRIIB links CRP signals with ITGAM functions: a G x G x G model of SLE.
    Alexander J Szalai; Fiscal Year: 2010
    Studies show that small variations in the CRP, FCGR2B, and ITGAM genes are associated with systemic lupus erythematosus (SLE)...
  7. Follicular dendritic cell activation and HIV pathogenesis
    Gregory F Burton; Fiscal Year: 2010
    ..FDCs trap ICs (including HIV) using CD32 (Fc?RIIB) and CD21 (Complement Receptor 2), although other as yet unknown receptors may also make contributions in ..
  8. Complement Genetics and Clinical Variability of Systemic Lupus Erythematosus
    CHACK Y YU; Fiscal Year: 2012
    ..We have also observed CNVs for the FCGR2-HSP70B-FCGR3 (FRH) complex including FCGR3B and FCGR3A at chromosome 1q23...
  9. FOLLICULAR ANTIGEN BINDING DENDRITIC CELLS
    John Tew; Fiscal Year: 2009
    ..FDCs that we believe are important in FDC-B cell-T cell interactions including: Ag-Ab complexes, CD21L, CD23, CD32/FcyRIIB, CD40, CD44, CD54/ICAM-1, CD106/VCAM-1, and CD320/8D6;3) Products secreted by FDCs that influence GC ..
  10. The Role of CD32 in the Basophil Response to Specific Immunotherapy
    Donald W Macglashan; Fiscal Year: 2012
    ..will test th hypothesis that blocking IgG exerts an influence on the human basophil response through cell surface CD32b (FcgRIIb)...
  11. Development of a Novel Bi-Specific Antibody Based Therapeutic that Simultaneously
    Maria Concetta Veri; Fiscal Year: 2010
    ..specificity for B-cells by incorporating specificity for the B cell receptor (CD79B) and an inhibitory receptor (CD32B) to enable exploitation of physiologic negative signaling via activation-inhibition coupling for pharmacologic ..
  12. Comparison of B Cell Differentiation in Mice and Humans
    MAX DALE COOPER; Fiscal Year: 2010
    ..transgenes, and (iv) examine the effects of ligating cell surface receptors (preBCR, BCR, IL7R, CD19, CD32, and CD40) on growth and differentiation of these B lineage cells...
  13. DIFFERENTIAL CYTOKINE SECRETION BY BASOPHILS
    John Schroeder; Fiscal Year: 2002
    ..Perturbation of CD40L or CD32 (IgG receptor) will be tested for effects on IL-4/IL-13 secretion...
  14. Modulation of B-cell tolerance by coreceptor molecules
    ROBERT RICKERT; Fiscal Year: 2005
    ..co-receptors as applied to the physiologic context of immune complexes and C3d-bound antigen co-engaging CD19/CD21/CD32 and the BCR...
  15. Tissue-Specific Expression and Regulation of the Inhibitory lgG Fc Receptor
    Kaihong Su; Fiscal Year: 2009
    ..mechanisms underlying the tissuespecific regulation of FcgammaRllb by characterizing the regulatory elements in FCGR2B gene and the tissue-specific transcription factors...
  16. NOVEL CD32 ISOFORMS MODULATE NK CELL FUNCTIONS
    PENELOPE MOREL; Fiscal Year: 2003
    ..These studies are of potential significance because NK cells have not been previously shown to express CD32 and thus this potentially represents a new means of activating and/or regulating NK cell lysis...
  17. FOLLICULAR ANTIGEN BINDING DENDRITIC CELLS
    John Tew; Fiscal Year: 2006
    ..The specific aims are: 1. To determine whether FDC morphology and surface molecules (i.e., CD21, CD21L, CD23, CD32, CD35, CD4O, CD54, CD64, CD1O6, FDC-M1, FDC-M2 & IgG) can be regulated in vitro by manipulating GC B and T ..
  18. ANALYSIS OF B-CELL RECEPTOR CALCIUM SIGNALING
    Andrew Scharenberg; Fiscal Year: 2004
    ..abstract_text> ..
  19. MAPPING CHROMOSOMES AND GENES IN RELATION TO LEUKEMIA
    Raju Chaganti; Fiscal Year: 2005
    ..4. Investigate the functional significance of FCGR2B gene deregulation in translocations involving the 1q21-22 region 5...
  20. IGG PLACENTAL TRANSPORT: ENDOTHELIAL CAVEOLAE
    John Robinson; Fiscal Year: 2004
    ..Our approaches to testing the predictions of this hypothesis incorporate methods of cell biology, immunology, biochemistry, ultrastructural analysis, and molecular biology. ..
  21. Mechanism of Antibody Therapy in Human B Cell Lymphoma
    Wen Kai Weng; Fiscal Year: 2007
    ..The knowledge generated from this project will help us to design better ways to use monoclonal antibodies and to develop new reagents to treat patients with B cell lymphoma. [unreadable] [unreadable]..
  22. Targeting FcRs on DCs for Ag-Specific Tolerance
    Adam Boruchov; Fiscal Year: 2008
    ..We have identified the activating (CD32a) and inhibitory (CD32b) isoforms of Fc-gammaRII co-expressed on populations of freshly isolated human DCs and on human DCs derived from ..
  23. Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic Cancer
    Changyi Chen; Fiscal Year: 2008
    ..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
  24. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2009
    ..abstract_text> ..
  25. Signaling by IgG receptors leading to phagocytosis
    KENNETH COGGESHALL; Fiscal Year: 2006
    ..The results will provide a better understanding of molecular process involved in clearance of infectious agents in humans. ..
  26. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    ..congenic (congenic for the Nba2 interval on C57BL/6 genetic background) mice down-regulate the expression of the Fcgr2b gene (encoding the inhibitory Fc receptor Fc3RIIB)...
  27. Inhibitory Fcgamma receptors: Role in Autoimmunity
    MARY CROW; Fiscal Year: 2007
    ..abstract_text> ..
  28. Novel Biological Activities of Anti-Viral Antibody
    Donald Forthal; Fiscal Year: 2006
    ..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
  29. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2007
    ..The data obtained from the proposed research will be useful in understanding and designing therapies to inhibit IC mediated tissue injury in autoimmune and infectious diseases. ..
  30. Allergy Therapy with Chimeric Human Ig Proteins
    Andrew Saxon; Fiscal Year: 2007
    ..Further, understanding of the mechanisms underlying the control of activating receptors by inhibitory receptors will have broad reaching implications for the manipulation the immune response. ..
  31. Tissue engineering of small diameter vascular graft
    Changyi Chen; Fiscal Year: 2006
    ..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
  32. MECHANISMS OF EOSINOPHIL DEGRANULATION IN HUMAN DISEASE
    Hirohito Kita; Fiscal Year: 2010
    ..Relevance: Patients with asthma have persistent respiratory problems. This research will investigate how the interaction of immune cells and our environment cause and worsen the disease. ..
  33. Molecular Surgeon Symposium on Vascular Injury, Repair
    Changyi Chen; Fiscal Year: 2005
    ..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
  34. ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSION
    Changyi Chen; Fiscal Year: 2002
    ....
  35. MATERNAL ALCOHOL IMPAIRS FETAL ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2002
    ..Understanding the modulatory role of GSH availability in AM function will broaden our understanding of GSH supplements not only as a possible therapy for infants exposed to ETOH in utero but premature infants in general. ..
  36. MYCOPLASMA INFECTIONS AND CHILDHOOD ASTHMA
    T Atkinson; Fiscal Year: 2002
    ..Finally, I plan to investigate the effects of infection in a mouse model of asthma, which will permit the use of deletional mutant strains in the investigation of pathogenic mechanisms. ..
  37. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2002
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets. ..
  38. FCGAMMA RECEPTOR IN IMMUNE-COMPLEX MEDIATED INFLAMMATION
    Luminita Pricop; Fiscal Year: 2002
    ....
  39. Developmental Pathobiology of Lymphocyte Fcy Receptors
    Richard Lynch; Fiscal Year: 2003
    ..Recent findings suggest that FcgRlll (CD16), an ITAM-containing protein kinase-activation receptor, and FcgRll (CD32), an ITIM-containing protein kinase-inhibitory receptor, mediate positive and negative lymphopoietic signals, ..
  40. PHOSPHATIDYLINOSITOL 3 KINASE IN B CELL ACTIVATION
    KENNETH COGGESHALL; Fiscal Year: 2003
    ..Such information may reveal novel therapeutic targets in a variety of pathologic conditions and contribute to the etiology of such diseases. ..
  41. Genetic Polymorphisms in Wegener's Granulomatosis
    JEFFREY EDBERG; Fiscal Year: 2003
    ....
  42. NOVEL SEROTHERAPY STRATEGIES--PLASMA CELL MALIGNANCIES
    STEVEN TREON; Fiscal Year: 2004
    ..Analogous to our work with Muc-1, we will also attempt to identify other PCD selective targets by generating and examining mAbs specific to the plasma cell glycoform of CD138. ..
  43. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
    ..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
  44. Reprogramming Activation of Cytotoxic T lymphocytes
    Luminita Pricop; Fiscal Year: 2004
    ..Our scope is to explore the potential to induce tolerogenic MDC8s to be used for deletion of antigen-specific CTLs as a therapeutic approach in autoimmune diseases. ..
  45. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
    ..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
  46. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
    ..abstract_text> ..
  47. ALCOHOL'S EFFECTS ON THE DEVELOPING ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2006
    ..abstract_text> ..
  48. CLINICAL AND FUNDAMENTAL IMMUNOLOGY
    Andrew Saxon; Fiscal Year: 2006
    ..abstract_text> ..
  49. Systemic Vasculitis: Host Factors in Tissue Injury
    JEFFREY EDBERG; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  50. FcRlll Blockade as a Treatment for Autoimmune Disease
    Leslie Johnson; Fiscal Year: 2004
    ..the studies outlined in this application will provide the basis for expanded production, characterization and further safety and efficacy studies of this molecule in small animals and primates, ultimately leading to human clinical trials ..
  51. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2009
    ..abstract_text> ..
  52. THE FUNCTION OF T-BET IN T HELPER CELL DEVELOPMENT
    Stanford Peng; Fiscal Year: 2003
    ..abstract_text> ..
  53. Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis Patients
    Hirohito Kita; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. XENOBIOTICS AND ALLERGIC INFLAMMATION
    Andrew Saxon; Fiscal Year: 2005
    ..The projects are supported by a DEP collection and fractionation core, a mouse core, and a administrative, patient and sample coordination core. ..
  55. HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIA
    Changyi Chen; Fiscal Year: 2002
    ....