FCER1A

Summary

Gene Symbol: FCER1A
Description: Fc fragment of IgE receptor Ia
Alias: FCE1A, FcERI, high affinity immunoglobulin epsilon receptor subunit alpha, Fc IgE receptor, alpha polypeptide, Fc epsilon RI alpha-chain, Fc epsilon receptor Ia, Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, Fc-epsilon RI-alpha, high affinity immunoglobulin epsilon receptor alpha-subunit, igE Fc receptor subunit alpha, immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
Species: human

Top Publications

  1. ncbi GM-CSF downmodulates c-kit, Fc(epsilon)RI(alpha) and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells
    P Welker
    Department of Dermatology and Allergy, Humboldt University, Berlin, Germany
    Arch Dermatol Res 293:249-58. 2001
  2. ncbi Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria
    Jin Sik Bae
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    J Allergy Clin Immunol 119:449-56. 2007
  3. pmc Regulation of the high affinity IgE receptor (Fc epsilonRI) in human neutrophils: role of seasonal allergen exposure and Th-2 cytokines
    Martin P Alphonse
    Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 3:e1921. 2008
  4. ncbi Sequence variants in the FcepsilonRI alpha chain gene
    Toshiki Shikanai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 93:37-41. 2002
  5. ncbi A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases
    Masanari Hasegawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:1927-33. 2003
  6. ncbi Genetic polymorphisms of the novel FCERIA gene region: relation to total serum IgE levels
    Daniel P Potaczek
    Ann Allergy Asthma Immunol 98:500-1. 2007
  7. ncbi Two different transcription factors discriminate the -315C>T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T
    Shunsuke Kanada
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 180:8204-10. 2008
  8. doi Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma
    Nami Shrestha Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, South Korea
    Respir Med 102:1132-9. 2008
  9. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
  10. doi FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding
    Daniel P Potaczek
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Immunogenetics 61:649-55. 2009

Research Grants

  1. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
  2. Adapter molecules on C3a receptor signaling in mast cells
    Hydar Ali; Fiscal Year: 2009
  3. Joshua A Boyce; Fiscal Year: 2016
  4. Structural Studies of IgE Receptors
    Theodore S Jardetzky; Fiscal Year: 2010
  5. Stephen C Dreskin; Fiscal Year: 2015
  6. STRUCTURE AND FUNCTION OF THE HIGH AFFINITY IGE RECEPTOR
    Michael Robertson; Fiscal Year: 1999
  7. Efficacy of IgE in Mediating Allergic Reactions in Vivo
    Donald W Macglashan; Fiscal Year: 2010
  8. Bridget S Wilson; Fiscal Year: 2016
  9. Immunological response to Chinese herbal medicine in food allergy
    Julie Wang; Fiscal Year: 2013
  10. Targeting sphingosine kinases in FceRI-mediated allergic responses
    Sarah Spiegel; Fiscal Year: 2012

Patents

  1. HYBRID Fc RECEPTOR MOLECULES

Scientific Experts

Detail Information

Publications179 found, 100 shown here

  1. ncbi GM-CSF downmodulates c-kit, Fc(epsilon)RI(alpha) and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells
    P Welker
    Department of Dermatology and Allergy, Humboldt University, Berlin, Germany
    Arch Dermatol Res 293:249-58. 2001
    ..GM-CSF may therefore function as a regulatory factor in mast cell growth and differentiation under normal and pathological conditions...
  2. ncbi Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria
    Jin Sik Bae
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    J Allergy Clin Immunol 119:449-56. 2007
    ..Although the mechanism that underlies aspirin hypersensitivity is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU)...
  3. pmc Regulation of the high affinity IgE receptor (Fc epsilonRI) in human neutrophils: role of seasonal allergen exposure and Th-2 cytokines
    Martin P Alphonse
    Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 3:e1921. 2008
    ....
  4. ncbi Sequence variants in the FcepsilonRI alpha chain gene
    Toshiki Shikanai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 93:37-41. 2002
    ..We conclude that homozygosity for the C allele of FcepsilonRI alpha chain variant is associated with lower IgE levels...
  5. ncbi A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases
    Masanari Hasegawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:1927-33. 2003
    ..Our findings for the first time demonstrate the presence of FcepsilonRIalpha polymorphism related to the allergic diseases...
  6. ncbi Genetic polymorphisms of the novel FCERIA gene region: relation to total serum IgE levels
    Daniel P Potaczek
    Ann Allergy Asthma Immunol 98:500-1. 2007
  7. ncbi Two different transcription factors discriminate the -315C>T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T
    Shunsuke Kanada
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 180:8204-10. 2008
    ..The findings demonstrate that a -315 SNP significantly affects human FcepsilonRI alpha-chain promoter activity and expression level of FcepsilonRI on basophils by binding different transcription factors to the SNP site...
  8. doi Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma
    Nami Shrestha Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, South Korea
    Respir Med 102:1132-9. 2008
    ....
  9. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
    ..Functional variants in the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) on chromosome 1q23 (rs2251746 and rs2427837) were strongly associated with total IgE levels in all cohorts with P ..
  10. doi FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding
    Daniel P Potaczek
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Immunogenetics 61:649-55. 2009
    ..Indeed, we confirmed preferential binding of the YY1 transcription factor to the -18483C allele, resulting in lower transcriptional activity when compared with the -18483A allele...
  11. doi FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients
    Y Niwa
    Atopy Allergy Research Center, Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Immunogenet 37:139-41. 2010
    Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects...
  12. ncbi The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor
    H Kuster
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Disease, Rockville, Maryland 20852
    J Biol Chem 267:12782-7. 1992
    ....
  13. ncbi Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation
    D Maurer
    Department of Dermatology, University of Vienna Medical School, Austria
    J Immunol 157:607-16. 1996
    ..This receptor occurs on the surface of these cells as a multimeric structure containing Fc epsilon RI alpha- and Fc epsilon RI gamma-chains but, unlike its counterpart on basophils, lacking Fc epsilon RI beta...
  14. doi Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life
    C M Chen
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Allergy 64:1327-32. 2009
    In a recent genome wide scan, a functional promoter variant (rs2251746) in the gene encoding the alpha chain of the high affinity receptor for immunoglobulin E (IgE) (FCER1A) was identified as major determinant of serum IgE levels.
  15. doi Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk
    J M Mahachie John
    Systems and Modeling Unit, Department of Electrical Engineering and Computer Science, University of Liege, Liege, Belgium
    Allergy 65:875-82. 2010
    ..The high-affinity receptor for IgE, which is composed of one alpha (FCER1A), one beta (FCER1B), and two gamma (FCER1G) subunits, represents the central receptor of IgE-induced reactions...
  16. pmc Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)
    T Bieber
    Department of Dermatology, University of Munich Medical School, Germany
    J Exp Med 175:1285-90. 1992
    ..Specific transcripts for Fc epsilon RI alpha and Fc epsilon RI gamma were detected in LC and correspond to those of human basophils and of the human ..
  17. pmc Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9
    J R Tversky
    Department of Medicine, Johns Hopkins Asthma and Allergy Center, Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
    Clin Exp Allergy 38:781-8. 2008
    ..Whether or not TLR9 and/or Fc epsilon RI levels and their function on dendritic cells relate to allergic status is unknown...
  18. ncbi Quantitation of tryptase, chymase, Fc epsilon RI alpha, and Fc epsilon RI gamma mRNAs in human mast cells and basophils by competitive reverse transcription-polymerase chain reaction
    H Z Xia
    Department of Medicine, Virginia Commonwealth University, Richmond 23298, USA
    J Immunol 154:5472-80. 1995
    Competitive reverse transcription-PCR assays developed for human tryptase, chymase, Fc epsilon RI alpha, and Fc epsilon RI gamma mRNA molecules were applied to the HMC-1 leukemic mast cell line, the KU812 leukemic basophil cell line, ..
  19. doi Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on Fc(epsilon)RI expression
    Sun Yup Shim
    Institute of Marine Life Science, Pukyong National University, Busan, Republic of Korea
    Bioorg Med Chem 17:4734-9. 2009
    ..stolonifera...
  20. ncbi Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19
    K Hupp
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 143:3787-91. 1989
    ..gene for FC epsilon RI gamma is found at the distal end of mouse chromosome 1, clustered in a region where Fc epsilon RI alpha has also been linked to Fc gamma RII...
  21. ncbi Rat CD16 is defined by a family of class III Fc gamma receptors requiring co-expression of heteroprotein subunits
    D L Farber
    Department of Biological Sciences, University of California, Santa Barbara 93106
    J Immunol 146:4352-61. 1991
    ..insertion sequences containing the unique LFAVDTGL motif conserved in all other class III Fc gamma and Fc epsilon RI alpha receptor sequences...
  22. ncbi Modulation of high-affinity IgE receptor expression in blood monocytes: opposite effect of IL-4 and glucocorticoids
    P Gosset
    INSERM U416, Institut Pasteur, Lille, France
    J Allergy Clin Immunol 107:114-22. 2001
    ..The expression of high-affinity IgE receptor (Fc epsilon RI) is increased in blood monocytes (BMs) from allergic patients compared with those of nonatopic subjects (NASs)...
  23. ncbi Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc epsilon RI): role in asthma
    A S Gounni
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    FASEB J 15:940-9. 2001
    ..We have examined the expression of Fc epsilon RI by PMNS: mRNA and cell surface expression of Fc epsilon RI alpha chain was identified on PMNs from asthmatic subjects...
  24. ncbi Developing antibodies for targeting immunoglobulin and membrane-bound immunoglobulin E
    Tse Wen Chang
    Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Allergy Asthma Proc 27:S7-14. 2006
    ..Fc receptors (FcERI) on mast cells and basophils and by the low-affinity IgE...
  25. ncbi [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors
    A Buku
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pept Res 66:132-7. 2005
    ..In contrast to MCD peptide, [Ala12]MCD showed a 50% inhibition of IgE binding to the Fc epsilon RI alpha mast cell receptor by using rat basophilic leukemia (RBL-2H3) mast cells and fluorescence polarization...
  26. doi Systems biology of ovine intestinal parasite resistance: disease gene modules and biomarkers
    Haja N Kadarmideen
    Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Davies Laboratory, PMB PO Aitkenvale, Townsville, QLD 4814, Australia
    Mol Biosyst 7:235-46. 2011
    ..0132) and positive regulation of NFκβ transcription factor activity (p = 0.00208). We report FCER1A, a gene encoding a high-affinity receptor for the Fc region of immunoglobulin E, which is linked to innate ..
  27. ncbi Multiple drug hypersensivity: insight into the underlying mechanism and correlation with autoimmune diseases
    G Colombo
    Allergy and Immunology Department, IRCCS San Raffaele Hospital, Milan, Italy
    Eur Ann Allergy Clin Immunol 41:50-5. 2009
    ....
  28. ncbi CD52 is expressed on human mast cells and is a potential therapeutic target in Waldenstrom's Macroglobulinemia and mast cell disorders
    Daniel Ditzel Santos
    Bing Center for Waldenstrom s Macroglobulinemia, Dana Farber Cancer Institute
    Clin Lymphoma Myeloma 6:478-83. 2006
    ..One potential target of alemtuzumab is bone marrow mast cells (BMMCs), which provide growth and survival signaling for WM lymphoplasmacytic cells...
  29. ncbi [Eosinophil, beneficial or harmful: a cell entirely part of immune response]
    M Capron
    Centre d Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France
    C R Seances Soc Biol Fil 188:39-46. 1994
    ..eosinophils expressed IgE binding molecules belonging to different gene superfamilies (CD23, Mac2/epsilon BP and FceRI), as well as two different IgA receptors (Fc alpha R, and secretory component binding site), participating both in ..
  30. doi Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha)
    Daniel P Potaczek
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Immunol Res 45:75-84. 2009
    Our knowledge on the variability of FCER1A gene encoding for alpha-subunit of the high-affinity immunoglobulin E receptor (FcepsilonRI) that plays a central role in the pathogenesis of allergy and related disorders, has been recently much ..
  31. ncbi Antihistamines do not inhibit the flare induced by the intradermal injection of autologous plasma in chronic urticaria patients
    R Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, MI, Italy
    Eur Ann Allergy Clin Immunol 41:181-6. 2009
    There is some evidence suggesting that factors other than autoantibodies to FceRI or IgE and histamine released from mast cells may play a role in skin autoreactivity that characterizes many patients with chronic urticaria (CU) and, ..
  32. doi Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells
    Ekaterina Shumilina
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 26:699-706. 2010
    ..Antigen stimulation via the FceRI receptor was followed by Ca(2+) entry leading to increase of cytosolic Ca(2+) activity in pdk1(wt) BMMCs, an ..
  33. doi GATEWAY technology and E. coli recombinant system produce a properly folded and functional recombinant allergen of the lipid transfer protein of apple (Mal d 3)
    Jean Philippe Borges
    Surfaces Cellulaires et Signalisation chez les Végétaux, UMR UPS CNRS 5546, Universite de Toulouse, 24 Chemin de Borde Rouge, 31326 Castanet, Tolosan, France
    Protein Expr Purif 70:277-82. 2010
    ..in vitro degranulation activity measured on transformed rat basophil leukemia cells expressing the human Fc epsilon RI alpha-subunit of rMal d 3 is similar to those of the native allergen purified from apple fruits...
  34. ncbi [Mast cell Toll-like receptors (TLRs)]
    Ewa Brzezińska-Błaszczyk
    Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi, 92 213 Łódź
    Postepy Hig Med Dosw (Online) 64:11-21. 2010
    ..What is more, it is now suggested that TLRs might regulate IgE-FceRI-dependent mast cell stimulation...
  35. pmc Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, University of Ghent, 9000 Ghent, Belgium
    J Exp Med 207:2097-111. 2010
    ..take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI(+) DCs readily did...
  36. ncbi The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding
    J Hakimi
    Department of Immunopharmacology, Roche Research Center, Hoffmann La Roche, Inc, Nutley, New Jersey 07110
    J Biol Chem 265:22079-81. 1990
    The alpha subunit of the FcERI binds IgE with high affinity...
  37. pmc Specific inhibition of immunoglobulin E-mediated allergic reaction using antisense Fc epsilon RI alpha oligodeoxynucleotides
    H M Kim
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    Immunology 93:589-94. 1998
    ..the ability of an antisense immunoglobulin E (IgE) receptor alpha-subunit oligodeoxynucleotide (Fc epsilon RI alpha ODN) specifically to inhibit IgE-mediated allergic reactions in the mouse...
  38. ncbi [The high-affinity IgE receptor: lessons from structural analysis]
    Ulrich Blank
    Institut Pasteur, Unite d Immuno Allergie, 25, rue du Docteur Roux, 75724 Paris, France
    Med Sci (Paris) 19:63-9. 2003
    The high affinity receptor for IgE, FcERI, is at the core of the allergic reaction. This receptor is expressed mainly on mast cells and basophils...
  39. ncbi Oxidative stress in allergic and inflammatory skin diseases
    Yoshimichi Okayama
    Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Curr Drug Targets Inflamm Allergy 4:517-9. 2005
    ..Mast cells generate mainly intracellular ROS following the aggregation of FceRI; these ROS may act as secondary messengers in the induction of several biological responses...
  40. ncbi Cytogenetic mapping of immunity-related genes in the domestic horse
    P Musilova
    Department of Genetics and Reproduction, Veterinary Research Institute, Brno 621 32, Czech Republic
    Anim Genet 36:507-10. 2005
    Chromosomal locations of 19 horse immunity-related loci (CASP1, CD14, EIF5A, FCER1A, IFNG, IL12A, IL12B, IL12RB2, IL1A, IL23A, IL4, IL6, MMP7, MS4A2, MYD88, NOS2A, PTGS2, TFRC and TLR2) were determined by fluorescence in situ ..
  41. ncbi Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab
    Irina Mirkina
    Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A 1235 Vienna, Austria
    Immunol Lett 109:120-8. 2007
    Aggregation of the alpha-chain of the high affinity IgE receptor (Fc epsilon RI alpha) on mast cells or basophils after cross-linking of receptor-bound IgE by its antigen or an anti-IgE antibody results in cell activation and release of ..
  42. pmc A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study
    Mark Granada
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 129:840-845.e21. 2012
    ..Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation...
  43. ncbi FES/FER kinase signaling in hematopoietic cells and leukemias
    Andrew W B Craig
    Department of Biochemistry, Queen s University, Division of Cancer Biology and Genetics, Queen s Cancer Research Institute, Kingston, Ontario K7L 3N6 Canada
    Front Biosci (Landmark Ed) 17:861-75. 2012
    ..In mast cells, SH2 ligands of FES/FER include KIT receptor PTK, and the high affinity IgE receptor (FceRI) that trigger rapid activation of FES/FER and signaling to regulators of the actin cytoskeleton and membrane ..
  44. ncbi [Association analysis between single-nucleotide polymorphisms in the FCER1A gene and serum total IgE level in patients with allergic rhinitis]
    Yuan Zhang
    Key Laboratory of Otorhinolaryngology, Head and Neck Surgery Capital Medical University, Ministry of Education, Beijing Institute of Otorhinolaryngology, Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47:289-93. 2012
    To investigate whether the single nucleotide polymorphisms (SNP) in the FCER1A gene are associated with serum total IgE level in Chinese allergic rhinitis (AR) cohort.
  45. doi Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics
    Daniel P Potaczek
    Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
    Pediatr Allergy Immunol 24:441-9. 2013
    Recently, three genome-wide association studies (GWAS) demonstrated FCER1A, the gene encoding a ligand-binding subunit of the high-affinity IgE receptor, to be a major susceptibility locus for serum IgE levels...
  46. pmc Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali
    Bakary Maiga
    Malaria Research and Training Center Department of Epidemiology of Parasitic Diseases Faculty of Medicine, Pharmacy and Odonto Stomatology, BP 1805, Bamako, USTTB, Mali Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    PLoS ONE 8:e75675. 2013
    ..Moreover, polymorphisms in FCER1A, RAD50, TNF, SLC22A4, and IL13 genes were correlated with antibody production (p-value<0.003)...
  47. pmc Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice
    Yun Jung Lee
    Department of Medicine Y J L, C L, M L, G K S, K I, A S B, P L, G P S, Brigham and Women s Hospital and Harvard Medical School, Department of Genetics and Complex Diseases K I, School of Public Health, Harvard University, and Department of Cell Biology J S, R N K, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02115 Department of Cardiology C L, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, People s Republic of China Institute of Cardiology M L, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430072, People s Republic of China and NutriOmique team M A, S A, K C, Institute of Cardiometabolism and Nutrition, INSERM, Unité Mixte de Recherche en Santé Unité 1166, and NutriOmique team M A, S A, K C, Universite Pierre et Marie Curie Paris 6, Paris F 75013 France
    Endocrinology 156:4047-58. 2015
    ..IgE receptor FcϵR1-deficient (Fcer1a(-/-)) mice and diet-induced obesity (DIO) mice demonstrated that FcϵR1 deficiency in DIO mice increased food ..
  48. ncbi The nucleotide sequence of dinitrophenyl-specific IgE and Fc(epsilon)RI alpha-subunit obtained from FE-3 hybridoma cells
    Y Tokeshi
    1st Department of Physiology, School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Hybrid Hybridomics 20:361-8. 2001
    ....
  49. ncbi Regulation of human Fc epsilon RI alpha-chain gene expression by multiple transcription factors
    Chiharu Nishiyama
    Allergy Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 168:4546-52. 2002
    Transcriptional regulation of the gene-encoding human Fc epsilon RI alpha-chain was analyzed in detail. EMSA revealed that either YY1 or PU.1 bound to the region close to that recognized by Elf-1...
  50. ncbi Inhibition of mast cell leukotriene release by thiourea derivatives
    Taracad K Venkatachalam
    Department of Chemistry, Parker Hughes Institute, 2699 Patton Road, Roseville, MN 55113, USA
    Bioorg Med Chem Lett 13:485-8. 2003
    ..thiazolyl and benzothiazolyl thioureas and examined their in vitro effects on the high affinity IgE receptor/FcERI-mediated mast cell leukotriene release...
  51. ncbi The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase
    Christine Tkaczyk
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:48474-84. 2003
    ..However, PI 3-kinase may contribute to the later phase of Fc epsilon RI-mediated degranulation in human mast cells...
  52. ncbi Roles of the transmembrane domain and the cytoplasmic domain of Fc epsilon RI alpha in immunoglobulin E-mediated up-regulation of surface Fc epsilon RI expression
    Y Okayama
    Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Clin Exp Allergy 37:451-8. 2007
    Human mast cells express both Fc epsilon RI alpha and Fc gamma RI alpha. IgE up-regulates Fc epsilon RI alpha expression, but IgG1 does not up-regulate Fc gamma RI alpha expression...
  53. doi Hyperexpression of the high-affinity IgE receptor-beta chain in chronic allergic keratoconjunctivitis
    Akira Matsuda
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 50:2871-7. 2009
    ....
  54. ncbi [Anti-IgE therapy in persistent allergic asthma]
    Roman Skiepko
    Klinika Alergologii i Chorob Wewnetrznych, Uniwersytetu Medycznego w Białymstoku
    Przegl Lek 66:141-4. 2009
    ..By reducing serum IgE levels, as well as FceRI and FceRII receptor expression on inflammatory cells, omalizumab inhibits development of inflammatory cascade...
  55. pmc Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children
    Monica Vasudev
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e32556. 2012
    ..While adult human conventional (cDC) and plasmacytoid (pDC) dendritic cells have been shown to express FcεRI, it is not known if this receptor is expressed in childhood and how its expression is governed by IgE...
  56. pmc Antigen-conjugated human IgE induces antigen-specific T cell tolerance in a humanized mouse model
    Günther Baravalle
    Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143
    J Immunol 192:3280-8. 2014
    ..Thus, targeting FcεRI on DCs via Ag-Fcε fusion protein may serve an alternative method to induce Ag-specific T cell tolerance in humans. ..
  57. ncbi mRNA variants encoding multiple forms of the high-affinity IgE receptor alpha subunit in transformed and nontransformed mast cells
    M W Robertson
    Medical Biology Institute, La Jolla, Calif
    Int Arch Allergy Appl Immunol 96:289-95. 1991
    ..Finally, mRNA variants have been translated in a cell-free system and the protein products partially characterized...
  58. ncbi Detergent-resistant membrane domains are required for mast cell activation but dispensable for tyrosine phosphorylation upon aggregation of the high affinity receptor for IgE
    T Yamashita
    Division of Hygienic Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    J Biochem 129:861-8. 2001
    Aggregation of the high affinity receptor for IgE (FceRI) on mast cells results in the rapid phosphorylation of tyrosines on the beta and gamma chains of the receptor by the Src family kinase Lyn, which initiates the signaling cascades ..
  59. ncbi Characterization of 'adult-type' mast cells derived from human bone marrow CD34(+) cells cultured in the presence of stem cell factor and interleukin-6. Interleukin-4 is not required for constitutive expression of CD54, Fc epsilon RI alpha and chymase, an
    Y Shimizu
    Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Clin Exp Allergy 32:872-80. 2002
    ..In vitro-derived human mast cells exhibit different properties, depending in part on the source of progenitor cells. Most investigations have used fetal liver, cord blood or peripheral blood. Few have used adult bone marrow...
  60. ncbi A review of asthma genetics: gene expression studies and recent candidates
    Giovanni Malerba
    Department of Mother and Child and Biology Genetics, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    J Appl Genet 46:93-104. 2005
    ..such as the A1AR and CLCA1 genes (chromosome 1), IL-1RN and DPP10 (2q14), HLA-G and TNF-a (6p21), GPRA (7p14), FceRI and GSTP1 (11q13), NOS1, IFNG, STAT6, VDR, and other genes (12q13-26), PHF11 and flanking genes (13q14), AACT and ..
  61. ncbi Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation
    Florian Hennersdorf
    University Clinic of Tubingen, Department of Internal Medicine II, Division of Hematology and Immunology, Tubingen, Germany
    Cell Res 15:325-35. 2005
    ..reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FceRI)...
  62. ncbi Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population
    Nina Joshi
    Genetics Branch, Center for Cancer Research, National Cancer Institute NIH, EPS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Res 66:6851-60. 2006
    ..such as antigen presentation, survival of T cells, and T-cell activation (HLA-DRA, HLA-DPA1, HLA-DBQ1, CD58, and FCER1A)...
  63. ncbi The autologous serum skin test in a cohort of chronic idiopathic urticaria patients compared to respiratory allergy patients and healthy individuals
    Emma Guttman-Yassky
    Department of Dermatology, Rambam Medical Center, Haifa, Israel
    J Eur Acad Dermatol Venereol 21:35-9. 2007
    A positive autologous serum skin test (ASST) is considered to reflect the presence of anti-FceRI and/or anti-IgE autoantibodies that are capable of activating mast and basophil cell degranulation...
  64. ncbi Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?
    Surajit Ganguly
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:32758-64. 2007
    ..Moreover, Fcer1a mRNA levels increased approximately 100-fold at night to levels that were higher than in other tissues examined...
  65. doi What do we know about the genetics of aspirin intolerance?
    N S Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    J Clin Pharm Ther 33:465-72. 2008
    ..Similarly, HLA-DB1*0609, ALOX5, FCER1A and HNMT have been identified as possible genetic markers for AIU...
  66. pmc Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells
    Trong Le
    Department of Pediatrics, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 123:217-23. 2009
    ..Immature human blood monocytoid dendritic cells (mDCs) express high-affinity receptors for IgE (Fc epsilon RI), yet their exact function and regulation remain poorly understood...
  67. pmc Polymerization of actin does not regulate desensitization in human basophils
    Donald MacGlashan
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Leukoc Biol 85:627-37. 2009
    ..These studies demonstrate that desensitization is not the result of two signaling pathways once considered relevant to down-regulation of IgE-mediated signaling...
  68. doi Antitumor IgE adjuvanticity: key role of Fc epsilon RI
    Elisa A Nigro
    Department of Biology and Genetics, University of Milan, Milan, Italy
    J Immunol 183:4530-6. 2009
    ..This finding suggests that the adjuvant effect of IgE could be exploited for human therapeutics...
  69. doi A circadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro
    Xiaojia Wang
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Brain Behav Immun 25:127-34. 2011
    ..The expression of fcer1a gene and FcεRIα protein displayed a circadian pattern following serum shock, with mean periods of 18.9 and 28...
  70. pmc Different implications of paternal and maternal atopy for perinatal IgE production and asthma development
    Chih Chiang Wu
    Department of Pediatrics, Show Chwan Memorial Hospital, 6 Lu Kung Road, Lu Kong, Changhua 50544, Taiwan
    Clin Dev Immunol 2012:132142. 2012
    ..Maternally transmitted genes GSTP1 and FceRI-beta are associated with lung function and allergic sensitization, respectively...
  71. doi Immunogenomic analysis of insect bite hypersensitivity in a model horse population
    Leona Vychodilova
    Institute of Animal Genetics, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, Brno, Czech Republic
    Vet Immunol Immunopathol 152:260-8. 2013
    ..When treated as a continuous trait, total IgE levels were associated with genes IGHE, FCER1A, IL4, IL4R, IL10, IL1RA, and JAK2...
  72. doi Chronic idiopathic urticaria and Graves' disease
    R M Ruggeri
    Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    J Endocrinol Invest 36:531-6. 2013
    ..disorder caused by circulating and functionally active IgG autoantibodies specific for the IgE receptor (FceRI) present on mast cells and basophils or for IgE itself...
  73. pmc Maternal allergy is associated with surface-bound IgE on cord blood basophils
    Adam P Matson
    Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA
    Pediatr Allergy Immunol 24:614-21. 2013
    ....
  74. doi A role of FCER1A and FCER2 polymorphisms in IgE regulation
    V Sharma
    Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
    Allergy 69:231-6. 2014
    Both FCER2 and FCER1A encode subunits of IgE receptors. Variants in FCER1A were previously identified as major determinants of IgE levels in genome-wide association studies.
  75. doi Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data
    V Sharma
    Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
    Allergy 69:1077-84. 2014
    Genome-wide association studies (GWAS) repeatedly identified 1q23 (FCER1A), 5q31 (RAD50-IL13 and IL4), and 12q13 (STAT6) as major susceptibility loci influencing the regulation of total serum IgE levels...
  76. pmc IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms
    Jing Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    EMBO Mol Med 6:952-69. 2014
    ..IgE induces CD4+ T-cell production of IL6 and IFN-γ, but reduces their production of IL10. FcεR1 deficiency (Fcer1a-/-) protects apolipoprotein E-deficient (Apoe-/-) mice from angiotensin-II infusion-induced AAAs and reduces ..
  77. pmc Nasal sensitization with ragweed pollen induces local-allergic-rhinitis-like symptoms in mice
    Yukinori Kato
    Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medical Science, University of Fukui, Fukui, Japan
    PLoS ONE 9:e103540. 2014
    ..b>Fcer1a(-/-) mice were defective in sneezing but developed normal eosinophilic infiltration...
  78. doi Anti-Eimeria activity of berberine and identification of associated gene expression changes in the mouse jejunum infected with Eimeria papillata
    Mohamed A Dkhil
    Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia
    Parasitol Res 114:1581-93. 2015
    ..g., Colec11, Saa2, Klra8, Clec1b, and Crtam, especially the genes Cpa3, Fcer1a, and Mcpt1, Mcpt2, and Mcpt4 involved in mast cell activity...
  79. pmc A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand
    Yi Sun
    From the Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, United Kingdom and
    Mol Cell Proteomics 14:1265-74. 2015
    ..These findings demonstrate how a protein microarray resource can be used to gain important insight into the function of platelet receptors and provide a mechanistic basis for the initiation of PEAR1 signaling in platelet aggregation. ..
  80. pmc Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation
    Hiam Abdala-Valencia
    Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 and
    J Immunol 195:1377-87. 2015
    ..Collectively, our data indicate that CD151 exerts negative regulation over IgE-induced late phase responses and cytokine production in mast cells. ..
  81. pmc Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
    John D Eicher
    Population Sciences Branch, National Heart Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA
    Am J Hum Genet 99:40-55. 2016
    ..not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants...
  82. ncbi Luteolin inhibits mast cell-mediated allergic inflammation
    S K Kritas
    Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece
    J Biol Regul Homeost Agents 27:955-9. 2013
    ..IgE with multivalent antigens initiate the activation of mast cells by promoting aggregation of FceRI. This cross-linking receptor-bound IgE by multivalent Ag initiates a cascade of intracellular reactions leading to ..
  83. pmc A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation
    Daocheng Zhu
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California, USA
    Nat Med 8:518-21. 2002
    ..and anti-dansyl IgE-mediated passive cutaneous anaphylaxis in transgenic mice expressing human Fc epsilon RI alpha. Our results show that this chimeric protein is able to form complexes with both Fc epsilon RI and Fc gamma ..
  84. ncbi Application of human Fc epsilon RI alpha-chain-transfected RBL-2H3 cells for estimation of active serum IgE
    Kayoko Takagi
    National Institute of Health Sciences, Division of Biochemistry and Immunochemistry, Tokyo, Japan
    Biol Pharm Bull 26:252-5. 2003
    ..The results suggested that our system will be useful for detecting FcepsilonRIalpha-bindable IgE in human serum...
  85. ncbi Immunoglobulin E-bearing antigen-presenting cells in atopic dermatitis
    Natalija Novak
    Division of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Allergy Asthma Rep 4:263-9. 2004
    ..Although intracellular expression of the Fc epsilon RI alpha-chain is induced by interleukin-4 (IL-4), the upregulation of surface levels on dendritic cells (DC) from ..
  86. pmc Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma
    Danielle M Backes
    Department of Epidemiology, Brown Public Health, Brown University, Providence, RI 02912, USA
    J Neurooncol 113:229-38. 2013
    ..Statistically significant associations were found between rs2494262 and rs2427824 of the FCER1A gene, which encodes the alpha chain of the high affinity immunoglobulin E receptor, and glioma risk (nominal trend ..
  87. pmc Epigenetic regulation of CD34 and HIF1A expression during the differentiation of human mast cells
    Aurelia Walczak-Drzewiecka
    Laboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Immunogenetics 65:429-38. 2013
    ..While the expression of CD34 dramatically decreased, the expression of mast cell-specific genes, including FCER1A, MS4A2, TPSB2, and CMA1, steadily increased...
  88. pmc CD3 zeta subunit can substitute for the gamma subunit of Fc epsilon receptor type I in assembly and functional expression of the high-affinity IgE receptor: evidence for interreceptor complementation
    F D Howard
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, MA
    Proc Natl Acad Sci U S A 87:7015-9. 1990
    ..subunit results in expression of IgE receptors at the oocyte surface as detected by binding of IgE or anti-Fc epsilon RI alpha subunit monoclonal antibody to intact oocytes...
  89. pmc Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients?
    E Fiebiger
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, University of Vienna Medical School, Austria
    J Clin Invest 96:2606-12. 1995
    ..As opposed to the selective occurrence of IgG anti-Fc epsilon RI alpha autoantibodies in CU patients, IgG anti-IgE antibodies were detected in all groups investigated (CU: 69%; ..
  90. ncbi The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase
    Y Ota
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 5430, USA
    Science 276:418-20. 1997
    ..Complex adaptor proteins such as Cbl can directly regulate the functions of the proteins they bind...
  91. pmc Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum
    Willem Lexmond
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA, USA
    J Immunol Methods 373:192-9. 2011
    ..In summary, we established and validated a standardized ELISA for the detection of sFcεRI. This novel method now allows for comparative analysis of sFcεRI levels in health and disease...
  92. ncbi Mucosal immunity and sublingual immunotherapy in respiratory disorders
    G Vitaliti
    Department of Pediatrics, University of Catania, Italy
    J Biol Regul Homeost Agents 26:S85-93. 2012
    ..in oral mucosa of dendritic cells (DCs) which express the high-affinity receptor for immunoglobulin (Ig)E (FcERI)...
  93. doi Current concepts of IgE regulation and impact of genetic determinants
    D P Potaczek
    Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
    Clin Exp Allergy 42:852-71. 2012
    ..association studies (GWAS) provided the power to identify genetic determinants for total serum IgE levels: 1q23 (FCER1A), 5q31 (RAD50, IL13, IL4), 12q13 (STAT6), 6p21.3 (HLA-DRB1) and 16p12 (IL4R, IL21R)...
  94. ncbi The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells
    L G Rider
    National Institute of Arthritis and Musculoskeletal Diseases, National Institutes of Health, Bethesda, MD 20892
    Gene 138:219-22. 1994
    Two isoforms of lck/yes-related novel (LYN) protein tyrosine kinase (PTK) appear to play a role in B-cell-IgM and FcERI receptor signaling...
  95. ncbi Anaphylaxis mediated through a humanized high affinity IgE receptor
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:1645-51. 1996
    ..a combination of transgenic and embryonic stem cell technology to generate a mouse line in which the murine Fc epsilon RI alpha-chain has been replaced with its human homologue...
  96. ncbi Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex
    J S Song
    Section on Chemical Immunology, NIAMSD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:26962-70. 1996
    ..The findings of this study may also be relevant to other members of the immune recognition receptor family that share the T-cell antigen receptor zeta/gamma chains...
  97. ncbi Interaction of human IgE with soluble forms of IgE high affinity receptors
    J Liu
    Department of Pharmaceutical Research and Development, Genentech, Inc, South San Francisco, California 94080, USA
    Pharm Res 14:1388-93. 1997
    ..The binding of IgE and IgE Fc epsilon RI alpha chain, the extracellular portion of IgE high affinity receptor (sFc epsilon RI alpha) was compared with the ..
  98. ncbi A tea catechin suppresses the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells
    Y Fujimura
    Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 49:2527-31. 2001
    ..Moreover, immunoblot analysis revealed that the total cellular expression of the Fc epsilon RI alpha chain decreased upon treatment with EGCg...
  99. ncbi Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail
    Z Kibar
    Department of Biochemistry, McGill University, Montreal, Canada
    Nat Genet 28:251-5. 2001
    ..The 0.6-cM/0.7-megabase (Mb) Lp interval is delineated proximally by D1Mit113/Apoa2/Fcer1g and distally by Fcer1a/D1Mit149/Spna1 and contains a minimum of 17 transcription units...

Research Grants63

  1. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): By crosslinking IgE bound to the high affinity IgE receptor, FceRI, allergens initiate a complex sequence of events leading to release of mast cell inflammatory mediators...
  2. Adapter molecules on C3a receptor signaling in mast cells
    Hydar Ali; Fiscal Year: 2009
    It is well documented that aggregation of high affinity IgE receptors (FceRI) on mast cells mediates allergic and hypersensitivity diseases. Not surprisingly, this receptor has been the subject of intense research investigation...
  3. Joshua A Boyce; Fiscal Year: 2016
    ..afferent and efferent pathways of host responses, including the following areas: signal transduction via TCR and FceRI pathways;various protein kinases and adaptor proteins;counterregulatory receptors such as gp49B1 and the leukocyte ..
  4. Structural Studies of IgE Receptors
    Theodore S Jardetzky; Fiscal Year: 2010
    ..The interaction of IgE antibodies with two receptors, FceRI and CD23, couples the diversity of the IgE repertoire to effector cells of the immune system...
  5. Stephen C Dreskin; Fiscal Year: 2015
    ..binds to peanut allergens, little is known about how these allergens cross-link IgE/IgE receptor complexes (IgE/FceRI) to activate mast cells and basophils...
  6. STRUCTURE AND FUNCTION OF THE HIGH AFFINITY IGE RECEPTOR
    Michael Robertson; Fiscal Year: 1999
    ..One goal is to define the molecular features of the Fc epsilon RI alpha-subunit involved in IgE binding...
  7. Efficacy of IgE in Mediating Allergic Reactions in Vivo
    Donald W Macglashan; Fiscal Year: 2010
    ..Other aims in project by Macglashan address issues of FceRI expression, how the beta subunit of this receptor is controlled and its influence on overall expression of FceRI ..
  8. Bridget S Wilson; Fiscal Year: 2016
    ..The anchoring biology will remain focused on signaling through the high affinity IgE receptor (FceRI), a key player in allergies and asthma, and on the modulation of FceRI signaling by positive crosstalk with the ..
  9. Immunological response to Chinese herbal medicine in food allergy
    Julie Wang; Fiscal Year: 2013
    ..with decreased IgE, increased lgG2a, decreased peripheral basophils, and decreased cell surface expression of FceRI on mast cells and basophils...
  10. Targeting sphingosine kinases in FceRI-mediated allergic responses
    Sarah Spiegel; Fiscal Year: 2012
    ..Sphingolipid signaling is central to human allergic diseases and potentially amenable to therapeutic targeting. The proposed studies hold much promise for treatment of allergic disorders. ..
  11. Novel strategies for asthma therapy by regulating mast cell signaling by MyD88
    Hydar Ali; Fiscal Year: 2010
    ..is a substantial body of evidence that demonstrates an important role for mast cell high affinity IgE receptor (FceRI) in the pathogenesis of asthma...
  12. Jack H Freed; Fiscal Year: 2016
    ..In the second project on the dynamics of antigen-mediated clustering of Immunoglobulin E (IgE)-receptor (FceRI) complexes in membranes, it will be determined how protein-lipid and protein- protein interactions dictate their ..
  13. Regulation of mediator release from human mast cell by extracellular adenosine.
    GREGORIO VALENZUELA GOMEZ; Fiscal Year: 2012
    ..Our preliminary data reveal that high extADO (10-4 M) inhibits FceRI-mediated degranulation of MCTC (skin) mast cells, whereas low extADO (10-7 M) augments mediator release from the ..
  14. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    JEAN PIERRE M KINET; Fiscal Year: 2013
    The high affinity receptor for IgE (FceRI) is central to allergic reactions. It is a tetrameric structure (a[3y2) when expressed on mast cells and basophils...
  15. Jeremy S Edwards; Fiscal Year: 2015
    ..As a result, arbitrarily large aggregates may emerge through the multivalent cross-linking of FceRI/IgE complexes by the antigen...
  16. Ruslan Medzhitov; Fiscal Year: 2014
    ..We will examine the phenotype of allergen-activated basophils and compare it to the FceRI and IL-3 receptor activated basophils...
  17. CHARACTERIZATION OF DIFFERENT TYPES OF HUMAN MAST CELLS
    Lawrence Schwartz; Fiscal Year: 2009
    ..Aim 2 examines the activation of skin-derived MCTC cells through FcyRIIA as well as FceRI. Degradation of cytokines by proteases released from the same MCTC cells will be studied in vitro, and the in vivo ..
  18. Allergies, Genetic Susceptibility and Adult Glioma Risk
    Dominique S Michaud; Fiscal Year: 2011
    ..SNPs (both alleles and haplotypes) of genes strongly related to allergies or asthma (IL-4, IL-4Ralpha, IL-13, FceRI-p, IL-10, CTLA- 4), and known functional variants of two detoxification genes (GSTP1 and GSTT1) in relation to the ..
  19. Fc epsilon RI as a Receptor for Antigen Surveillance at Mucosal Surfaces
    THERESA SINGLETON; Fiscal Year: 2009
    The objective of this proposal is to test the hypothesis that FceRI can function as a receptor for antigen surveillance when expressed by dendritic cells (DC)...
  20. Immune Cell Responses in Food Hypersensitivity
    John Schroeder; Fiscal Year: 2009
    ..In particular, most all human DC subtypes thus far described express the high affinity IgE receptor (FceRI), indicating that these APCs function not only in sensitization but also in effector phases of allergic reactions...
  21. Mitchell H Grayson; Fiscal Year: 2016
    ..Paramyxoviral infection induces expression of the high affinity receptor for IgE (FceRI) on lung DC, followed by viral specific IgE...
  22. Studies on the role of FcERI-mediated DC activation in the gastrointestinal tract
    Barbara Platzer; Fiscal Year: 2010
    ..e. Fc-epsilon receptor I (FceRI). Due to the absence of FceRI on DCs in the rodent system little is known about its function and in vivo relevance...
  23. INDUCTION OF FOOD ALLERGY BY INTESTINAL DENDRITIC CELLS
    MITCHELL GRAYSON; Fiscal Year: 2009
    ..In the lung, viral infection induced expression of the high affinity receptor for IgE (FceRI) on DC. Cross-linking of this receptor led to release of a chemoattractant for Th2 cells...
  24. PROTEIN TYROSINE KINASES AND MAST CELL ACTIVATION
    Toshiaki Kawakami; Fiscal Year: 2001
    ..and their roles in the signal transduction pathway triggered by crosslinking of the high-affinity IgE receptor (FceRI)...
  25. Tec Kinases ltk and RlK in Mast Cell Signaling
    Leslie Berg; Fiscal Year: 2009
    ..we find that Itk-/- bone marrow-derived mast cells secrete enhanced levels of IL-4, IL-6, and IL-13 following FceRI stimulation...
  26. RECEPTOR AGGREGATION AND ITS EFFECTS
    BYRON B GOLDSTEIN; Fiscal Year: 2012
    ..Building on this work we will extend the model, adding the kinases, Fyn,which associates with FcERI, and Csk, which regulates the activity of Lyn and Fyn, as well as Csk-binding protein, a Lyn substrate that ..
  27. MONONUCLEAR PHAGOCYTE FUNCTION IN IMMUNOLOGIC DISEASES
    Robert P Kimberly; Fiscal Year: 2010
    ..is conferred by the unique cytoplasmic domain sequences of the "activating" receptors associated with the FceRI common gamma-chain...
  28. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    ..in EE patients, particularly tissue eosinophilia, cytokine and chemokine profiles, and levels of CD23, FceRI and tryptase, and (2) use the EST to monitor disease status following nutritional or corticosteroid treatments...
  29. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
    ..Our laboratory has produced monoclonal antibodies (mAbs) with a capacity to inhibit FceRI-mediated MC activation to use them as tools to identify and characterize novel inhibitory mechanisms of FcR-..
  30. Immune Dysregulation in Allergic Asthma
    Mary Lipscomb; Fiscal Year: 2006
    ..observation showing that basophils that don't release histamine following high affinity IgE receptor (FceRI) crossing-linking are deficient in the tyrosine kinase, Syk...
  31. Mechanism of IgE Mediated FceRI Regulation
    Jean Pierre Kinet; Fiscal Year: 2001
    DESCRIPTION (provided by the applicant): IgE mediates allergic responses by binding to a specific receptor, FceRI, on immune cells. Upon multivalent antigen binding, FceRI receptors become cross-linked, thus initiating activation events...
  32. Observing the IgE and FceRI signaling pathway via dielectric-filled nanoapertures
    CHRISTOPHER VAUGHN DAIGNEAU KELLY; Fiscal Year: 2012
    ..for near-field optical microscopy (ANOMs) Specific Aim 2: Characterize the optical properties of ANOMs for quantitative super-resolution microscopy Specific Aim 3: Measure local membrane heterogeneity induced by FC?RI clustering ..
  33. IGC REGULATION OF IGE-MEDIATED BASOPHIL DEGRANULATION
    John Cambier; Fiscal Year: 2001
    ..Adapted from Investigator's abstract) Binding of allergen to IgE complexed to its high affinity receptors (FceRI) on mast cells and basophils initiates release of histamine and other mediators...
  34. Allergy Therapy with Chimeric Human Ig Proteins
    Andrew Saxon; Fiscal Year: 2007
    ..Activation signals mediated by ITAMs (immunoreceptor tyrosine-based activation motifs) in the FceRI are subject to negative regulation by the ITIM (immunoreceptor tyrosine-based inhibitory motifs)-containing ..
  35. Immunological Basis of Egg Allergy
    Anna Nowak Wegrzyn; Fiscal Year: 2009
    ..effector function of IgE antibodies will be assessed by basophil release test with the use of passively sensitized FceRI-transfected rat basophil leukemia cell line stimulated with native and heat-inactivated egg proteins. 3...
  36. REDIRECTING THE IMMUNE RESPONSE TO ALLERGENS
    PAUL GUYRE; Fiscal Year: 2001
    ..Anti-CD64:FceRI, in which anti-CD64 is linked to the a-chain of FceRl, is designed to suppress IgE-specific responses even when ..
  37. Molecular Mechanisms Leading to Human Asthma
    Jean Pierre Kinet; Fiscal Year: 2005
    ..Project 4: Regulation of IgE receptor expression and function. The IgE/FceRI network plays a central role in allergic inflammation...
  38. Molecular Mechanisms Leading to Human Asthma
    Jean Pierre Kinet; Fiscal Year: 2001
    ..Project 4: Regulation of IgE receptor expression and function. The IgE/FceRI network plays a central role in allergic inflammation...
  39. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..and its individual functional domains, can negatively regulate mouse MC activation induced by signaling via FceRI or c-Kit (the SCF receptor) in vitro or in vivo, and will identify and characterize RabGEFI-interacting proteins ..
  40. IGA RECEPTORS ON HUMAN PHAGOCYTES
    LILIAN SHEN; Fiscal Year: 2000
    ..recent findings indicate that the FcaR ligand-binding chain associates with other membrane protein, in particular FceRI g chain, to form a multi-chain receptor complex...
  41. FUNCTION OF FCERI ON EPIDERMAL LANGERHANS CELLS
    TERESA BORKOWSKI; Fiscal Year: 2001
    ..Recently the high affinity receptor of IgE (FcERI) has been identified on LC. FcERI complex plays a central role in allergic inflammation...
  42. Tracking the 3-D intracellular spatial trajectory of an individual IgE molecule
    JAMES WERNER; Fiscal Year: 2009
    ..We will study the receptor mediated endocytosis of FceRI receptors on the rat mast cell line RBL-2H3...
  43. CELLULAR ASSEMBLY AND TRANSPORT OF THE IGE RECEPTOR
    Michael Robertson; Fiscal Year: 2004
    ..initiating requirement of the allergic response involves the interaction of IgE with its high affinity receptor (FceRI) expressed on hematopoietic cells...
  44. RECEPTOR AGGREGATION AND ITS EFFECTS
    Byron Goldstein; Fiscal Year: 2002
    ..The high affinity receptor for IgE, FceRI, expressed on basophils and stable transfectants, is the model system that will be used to study signaling ..
  45. THE ROLE OF SPHINGOSINE KINASE IN MAST CELL SIGNALING
    OKSOON CHOI; Fiscal Year: 2003
    ..In addition, the signaling mechanisms, which are upstream and downstream of FceRI-mediated mast cells...
  46. FUNCTIONAL STUDIES OF HTM4, A CD20/FCE RIB HOMOLOGUE
    CHAKAR ADRA; Fiscal Year: 2002
    ..forms the high affinity receptor far IgE on mast cells and functions as an amplifier of signals transduced by the FceRI. These three leucocyte proteins are highly relevant for both basic research and clinical applications: Anti-CD20 ..
  47. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    QIANA MATTHEWS; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Antigen stimulation to mast cells through high affinity receptors for IgE (FceRI) leads to Ca2+ mobilization and, as a consequence, the release of inflammatory mediators that are responsible for ..
  48. Immune Regulation of Cysteinyl Leukotriene Biosynthesis
    Bing K Lam; Fiscal Year: 2010
    ..Mast cells (MCs) respond to activation by innate stimuli or cross linking of the high-affinity receptor for IgE (FceRI) by generating eicosanoids, particularly the cysteinyl leukotrienes (cysLTs) and prostaglandin (PG) D2, providing ..
  49. REGULATION OF FCERI EXPRESSION
    Donald MacGlashan; Fiscal Year: 2000
    DESCRIPTION (Adapted from Investigator's abstract): The investigator has recently demonstrated that FceRI expression can be both down-regulated and up-regulated on human basophils and appears to be regulated by the IgE antibody...
  50. REGULATION OF MAST CELL CYTOKINE PRODUCTION
    Erwin Gelfand; Fiscal Year: 2002
    ..protein kinases which control the transcriptional regulation of cytokine production following aggregation of FceRI. We have cloned, characterized and identified a family of (four) serine/threonine protein kinases, the MEK kinases,..
  51. MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Erwin Gelfand; Fiscal Year: 2003
    ..to play an essential role in the activation of JNK and ERK5 following occupancy of mast cell surface receptors (FceRI, Kit or IL-3)...
  52. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2003
    ..He will investigate 1) whether there are differences between individuals in the betaWT/betaT ratio, and 2) whether these differences correlate with allergic status. ..
  53. NK CELL RECEPTORS AND THEIR LIGANDS
    LEWIS LANIER; Fiscal Year: 2005
    ..However, many of these activating receptors are associated with DAP12, CD3zeta, or the FcERI-y adaptor proteins...
  54. Role of the IgE-FceRI network in allergic inflammation
    Jean Pierre Kinet; Fiscal Year: 2005
    ..Role of the IgE-FceRi network in allergic inflammation...
  55. Src Family Kinase Regulation in Allergy
    Becky Vonakis; Fiscal Year: 2007
    Secretion of inflammatory mediators after allergen-induced aggregation of the high affinity IgE receptor (FceRI) on mast cells is a critical component of the pathogenesis of asthma and other allergic disorders...
  56. INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM
    Emelia Benjamin; Fiscal Year: 2003
    ..The proposed study provides a unique opportunity to assess the prognostic importance of inflammatory markers and is likely to yield new information that will directly improve the prevention and management of CVD. ..
  57. Lyn Kinase Regulation of FceRI-induced Mediator Release
    Becky Vonakis; Fiscal Year: 2003
    ..Initiation of signal transduction through the high affinity receptor for IgE (FcERI) requires phosphorylation of distinct tyrosine residues in the receptor's beta and gamma chains...
  58. Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study
    Emelia J Benjamin; Fiscal Year: 2010
    ..The proposed study will fundamentally contribute insight about the relations of inflammation and aging. ..
  59. Vascular Function in the Framingham Third Generation
    Emelia Benjamin; Fiscal Year: 2005
    ..The combination of investigator expertise and a well-characterized multi-generational sample will provide a unique vascular function data set, and will increase the understanding of the pathophysiology of HTN and CVD. ..
  60. Lyn Kinase-Mediated Regulation of Allergic Inflammation
    Becky Vonakis; Fiscal Year: 2005
    ..Initiation of signal transduction through the high affinity receptor for IgE (FceRI) requires phosphorylation of distinct tyrosine residues in the receptor's beta and gamma chains...
  61. Alteration of Human Dendritic Cell Subsets by RSV
    Michelle Gill; Fiscal Year: 2008
    ..This award will facilitate the transition of the candidate into an independent, academic physician scientist. ..
  62. Framingham: Inflammation, Genes & Cardiovascular Disease
    Emelia Benjamin; Fiscal Year: 2008
    ..These insights will fundamentally contribute to knowledge about the pathophysiology of CVD and may lead to improved prevention, risk stratification and management of CVD. ..
  63. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship. ..

Patents1

  1. HYBRID Fc RECEPTOR MOLECULES
    Patent Number: WO9106570-A1; Date:1991-05-16