FBLIM1

Summary

Gene Symbol: FBLIM1
Description: filamin binding LIM protein 1
Alias: CAL, FBLP-1, FBLP1, filamin-binding LIM protein 1, CSX-associated LIM, MIG2-interacting protein, migfilin, mitogen-inducible 2 interacting protein
Species: human

Top Publications

  1. ncbi A new member of the LIM protein family binds to filamin B and localizes at stress fibers
    Toshiro Takafuta
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania 19041, USA
    J Biol Chem 278:12175-81. 2003
  2. ncbi Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation
    Yizeng Tu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell 113:37-47. 2003
  3. pmc A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
    Hiroshi Akazawa
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Cell Biol 164:395-405. 2004
  4. ncbi Migfilin and its binding partners: from cell biology to human diseases
    Chuanyue Wu
    Department of Pathology, University of Pittsburgh, 707B Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Cell Sci 118:659-64. 2005
  5. ncbi Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration
    Yongjun Zhang
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:12397-407. 2006
  6. pmc Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma
    D J Papachristou
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Histopathology 51:499-508. 2007
  7. pmc Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome
    J E Lai-Cheong
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
    J Invest Dermatol 128:2156-65. 2008
  8. pmc Structural basis of the migfilin-filamin interaction and competition with integrin beta tails
    Yatish Lad
    Department of Pharmacology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:35154-63. 2008
  9. pmc Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk
    Sujay Subbayya Ithychanda
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:35113-21. 2009
  10. pmc Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling
    Jianping Zhao
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:34308-20. 2009

Research Grants

  1. Saliva and Serum Inflammatory Biomarkers in Periodontitis: A Study in Older Women
    Jean Wactawski Wende; Fiscal Year: 2010
  2. Alexandra M Machikas; Fiscal Year: 2014
  3. Chicago Endothelial Function Study
    Louise C Hawkley; Fiscal Year: 2010
  4. Lisa Ostrin; Fiscal Year: 2016
  5. Stimuli promoting the survival of spiral ganglion neurons
    Steven H Green; Fiscal Year: 2011
  6. Sherie L Morrison; Fiscal Year: 2015
  7. TILIA N KIMM; Fiscal Year: 2014
  8. Collaborative Model Addressing Mental Health in the Perinatal Period
    Cynthia D Connelly; Fiscal Year: 2012
  9. Vascular Calcium Channel Expression in Hypertension
    Nancy J Rusch; Fiscal Year: 2012
  10. Ian McKeague; Fiscal Year: 2016

Detail Information

Publications188 found, 100 shown here

  1. ncbi A new member of the LIM protein family binds to filamin B and localizes at stress fibers
    Toshiro Takafuta
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania 19041, USA
    J Biol Chem 278:12175-81. 2003
    ..The association between filamin B and FBLP-1 may play a hitherto unknown role in cytoskeletal function, cell adhesion, and cell motility...
  2. ncbi Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation
    Yizeng Tu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell 113:37-47. 2003
    Cell-extracellular matrix adhesion is an important determinant of cell morphology. We show here that migfilin, a LIM-containing protein, localizes to cell-matrix adhesions, associates with actin filaments, and is essential for cell shape ..
  3. pmc A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
    Hiroshi Akazawa
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Cell Biol 164:395-405. 2004
    ..yeast two-hybrid screening, we identified a novel LIM domain-containing protein, named CSX-associated LIM protein (Cal), that interacts with CSX/NKX2-5...
  4. ncbi Migfilin and its binding partners: from cell biology to human diseases
    Chuanyue Wu
    Department of Pathology, University of Pittsburgh, 707B Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Cell Sci 118:659-64. 2005
    ..One of the most recently identified is migfilin, a widely expressed protein consisting of an N-terminal filamin-binding domain, a central proline-rich domain and ..
  5. ncbi Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration
    Yongjun Zhang
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:12397-407. 2006
    ..We report here that migfilin, a recently identified component of cell-matrix adhesions, is a biphasic regulator of cell migration...
  6. pmc Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma
    D J Papachristou
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Histopathology 51:499-508. 2007
    ..Mitogen inducible gene-2 (Mig-2), kindlin and migfilin are recently identified cell-matrix adhesion proteins...
  7. pmc Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome
    J E Lai-Cheong
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
    J Invest Dermatol 128:2156-65. 2008
    ..In this study, we identified two previously unreported binding proteins of kindlin-1: kindlin-2 and migfilin. Co-immunoprecipitation and confocal microscopy studies show that these three proteins bind to each other and ..
  8. pmc Structural basis of the migfilin-filamin interaction and competition with integrin beta tails
    Yatish Lad
    Department of Pharmacology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:35154-63. 2008
    ..b>Migfilin is a recently identified adaptor protein that localizes at cell-cell and cell-extracellular matrix adhesion sites,..
  9. pmc Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk
    Sujay Subbayya Ithychanda
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:35113-21. 2009
    ..that all repeats in this subgroup can actually bind glycoprotein Ibalpha, integrins, and a cytoskeleton regulator migfilin in similar manners. These data provide a new view on the ligand specificity of the filamin repeats...
  10. pmc Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling
    Jianping Zhao
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:34308-20. 2009
    ..Here we show that migfilin, an integrin-proximal adaptor protein, interacts with Src and contributes to cell-ECM-mediated survival signaling...
  11. pmc Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin
    Sujay Subbayya Ithychanda
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochemistry 50:4229-31. 2011
    ..nuclear magnetic resonance spectroscopy that the autoinhibition can be relieved by integrin or integrin regulator migfilin. We further demonstrate that repeats 19 and 21 can simultaneously engage ligands...
  12. doi Migfilin regulates esophageal cancer cell motility through promoting GSK-3β-mediated degradation of β-catenin
    Huan He
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Mol Cancer Res 10:273-81. 2012
    b>Migfilin, a protein component of focal adhesions, has been implicated in regulation of cell-extracellular matrix adhesion and motility but the underlying mechanisms are not fully elucidated...
  13. pmc Migfilin, a molecular switch in regulation of integrin activation
    Sujay Subbayya Ithychanda
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:4713-22. 2009
    ..Here we show structurally that migfilin, a novel cytoskeletal adaptor highly enriched in the integrin adhesion sites, strongly interacts with the same ..
  14. doi Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial
    Panos Chondros
    Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands
    Lasers Med Sci 24:681-8. 2009
    ..BOP) at experimental sites, probing pocket depth (PPD), gingival recession (REC), and clinical attachment level (CAL). Primary outcome variables were changes in PPD and CAL...
  15. ncbi Augmented contributions of voltage-gated Ca2+ channels to contractile responses in spontaneously hypertensive rat mesenteric arteries
    K Matsuda
    Bockus Research Institute, Graduate Hospital, Philadelphia, PA 19146, USA
    Am J Hypertens 10:1231-9. 1997
    ..compared to normotensive subjects suggests that there is a greater contribution from voltage-gated Ca2+ channels (CaL) to vascular force maintenance in hypertensive arteries...
  16. pmc Does "mainstreaming" guarantee access to care for medicaid recipients with asthma?
    Y A Bair
    Graduate Group in Epidemiology and the Center for Health Services Research in Primary Care, University of California, Davis, USA
    J Gen Intern Med 16:475-81. 2001
    ..Recent reforms in the federal Medicaid program have attempted to integrate beneficiaries into the mainstream by providing them with managed care options. However, the effects of mainstreaming have not been systematically evaluated...
  17. ncbi Influence of fast, body weight and diet on serum cholesterol, triglycerides, and phospholipids concentrations in the aging rat
    J Boudet
    INSERM U 90, , Paris, France
    Horm Metab Res 20:734-7. 1988
    ..intake and daily body weight gain of old rats (40-50 weeks of age) were not significantly different with both diets tested (2900 and 3250 cal/kg). In conclusion old Wistar rats develop increased concentrations of serum lipids parameters.
  18. ncbi Prospective randomized trial to assess caloric and protein needs of critically Ill, anuric, ventilated patients requiring continuous renal replacement therapy
    C D Scheinkestel
    Department of Intensive Care, Alfred Hospital, Melbourne, Australia, Australia
    Nutrition 19:909-16. 2003
    ..We also determined whether these feeding regimes affected patient outcome...
  19. pmc Electrophysiological actions of phenytoin on N-methyl-D-aspartate receptor-mediated responses in rat hippocampus in vitro
    A J Laffling
    Department of Pharmacology, Syntex Research Centre, Edinburgh
    Br J Pharmacol 115:67-72. 1995
    ..3 x 10-6 M to 1 x 10-4M) attenuated the effects of the sodium channel activator,veratridine (2 x 10-6 M), on the CAl population spike amplitude (recorded in normal Krebs solution),indicating that the previously observed lack of ..
  20. ncbi Interaction of [D-Trp6, Des-Gly10] LHRH ethylamide and hydroxy propyl beta-cyclodextrin (HPbetaCD): thermodynamics of interaction and protection from degradation by alpha-chymotrypsin
    K N Koushik
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198-6025, USA
    Pharm Dev Technol 6:595-606. 2001
    ..an exothermic reaction between deslorelin and HPbetaCD with a low enthalpy of binding of approximately -600 cal/mol and a binding affinity of approximately -1.25 x 10(2) M-1...
  21. pmc Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones
    C H Davies
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 116:1859-69. 1995
    ..6 From these data it is concluded that the mGluRs in CAl pyramidal neurones responsible for these excitatory effects are similar to the mGluRs expressed by non-neuronal ..
  22. ncbi Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches
    J L Wennstrom
    Department of Periodontology, Institute of Odontology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Clin Periodontol 28:753-61. 2001
    ..In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated...
  23. ncbi [Studies on Chlamydia pneumoniae, strain TWAR infection. 2. Seroepidemiology of TWAR on healthy controls and patients with acute respiratory infections]
    T Kishimoto
    Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 64:986-93. 1990
    ..MFA) using in situ inclusions of Chlamydia pneumoniae (TW-183), Chlamydia trachomatis (L2) and Chlamydia psittaci (Cal 10) as antigens respectively...
  24. ncbi Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase
    Alex Grunau
    Department of Biochemistry, University of Leicester, UK
    Biochemistry 45:1421-34. 2006
    ..Similar heat capacity change (DeltaC(p)) values for 2',5'-ADP (-210 cal mol(-)(1) K(-)(1)), NADP(+) (-230 cal mol(-)(1) K(-)(1)), and H(4)NADP (-220 cal mol(-)(1) K(-)(1)) indicate no ..
  25. ncbi [Studies on Chlamydia pneumoniae, strain TWAR, infection. I. Experimental infection of C. pneumoniae in mice and serum antibodies against TWAR by MFA.]
    T Kishimoto
    Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 64:124-31. 1990
    ..pneumoniae TW-183, C. psittaci Cal 10 and C. trachomatis L2 strains were assayed by MFA using in situ inclusions of each strain and compared...
  26. ncbi Supragingival plaque may modify the effects of subgingival bacteria on attachment loss
    Mine Tezal
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    J Periodontol 77:808-13. 2006
    ..This study evaluates the role of supragingival plaque level on the relationship between subgingival microorganisms and the risk of attachment loss...
  27. ncbi Acute effects of prolactin on passive calcium absorption in the small intestine by in vivo perfusion technique
    N Krishnamra
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Can J Physiol Pharmacol 76:161-8. 1998
    ..81 +/- 1.84 to 30.56 +/- 1.57 mmol/g dry weight (p < 0.05) by stimulating the lumen to plasma calcium flux (CaL-P). The jejunum responded to 0.2, 0.4, and 0...
  28. ncbi Evaluation of the first year of a pilot program in community pharmacy: HIV/AIDS medication therapy management for Medi-Cal beneficiaries
    Jan D Hirsch
    University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, 9500 Gilman Drive, Mail Code 0714, La Jolla, CA 92093 0714, USA
    J Manag Care Pharm 15:32-41. 2009
    ..In January 2005, a pilot program to evaluate MTM services for patients with HIV/AIDS began in California, allowing 10 HIV/AIDS specialty pharmacies to receive compensation for the MTM services that they provided to HIV/AIDS patients...
  29. ncbi Local anti-infective therapy: pharmacological agents. A systematic review
    Philip J Hanes
    Department of Periodontics, Medical College of Georgia, School of Dentistry, Augusta, GA 30912 1220, USA
    Ann Periodontol 8:79-98. 2003
    ..Over the past 20 years, locally delivered, anti-infective pharmacological agents, most recently employing sustained-release vehicles, have been introduced to achieve this goal...
  30. doi Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial
    Michele Paolantonio
    Department of Periodontology, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Periodontol 80:1479-92. 2009
    ..The present multicenter randomized study investigated the effects of a xanthan-based chlorhexidine (Xan-CHX) gel used as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis...
  31. ncbi Cost and utilization impacts of oral antihistamines in the California Medi-Cal program
    Joel W Hay
    Department of Pharmaceutical Economics and Policy, University of Southern California, Los Angeles, CA 90089, USA
    Value Health 8:506-16. 2005
    ..There are no empirical studies comparing the costs of treatment of SGAs relative to FGAs...
  32. ncbi Bioabsorbable membrane and bioactive glass in the treatment of intrabony defects in patients with generalized aggressive periodontitis: results of a 5-year clinical and radiological study
    Reiner Mengel
    Department of Periodontology, Philipps University Marburg, Marburg, Germany
    J Periodontol 77:1781-7. 2006
    ....
  33. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
    The aim of this study was to compare the performance of fecal lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil elastase (PMN-e), as well as serum C-reactive protein (CRP) in patients with inflammatory bowel diseases (..
  34. ncbi In most poorly controlled glyburide-treated type 2 diabetic patients drug withdrawal causes further increase in glycemia not accompanied by changes in insulin secretion
    A Lev-Ran
    Zamenhof Clinic, General Sick Fund, Tel-Aviv, Israel
    Horm Metab Res 30:108-10. 1998
    ..6%). Serum glucose, insulin and C-peptide were assayed before and 1 h and 2 h after a simulated meal load (355 Cal), after which the drug was replaced with placebo for 4 weeks, and the test repeated...
  35. ncbi Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practice
    J L Mahon
    Department of Medicine, University of Western Ontario, Canada
    Chest 115:38-48. 1999
    ..aim), and drug usage (secondary aim), between groups of patients with irreversible chronic airflow limitation (CAL) who were undergoing theophylline Theo-Dur; Key Pharmaceuticals; Kenilworth, NJ) therapy guided by n of 1 trials or ..
  36. ncbi Interleukin-1 gene polymorphisms and long-term stability following guided tissue regeneration therapy
    M De Sanctis
    Department of Periodontology, Bologna University, Italy
    J Periodontol 71:606-13. 2000
    ..The aim of the present study was to evaluate the impact of genotype on the maintenance of gained clinical attachment obtained after guided tissue regeneration (GTR) surgical therapy in deep intrabony defects...
  37. ncbi Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study
    A Sculean
    Department of Periodontology and Conservative Dentistry, University of Saarland, Homburg, Germany
    J Clin Periodontol 28:397-403. 2001
    ..However, it is yet unknown whether the combination of EMD and GTR may additionally favor the regeneration process...
  38. ncbi Surgical treatment of periodontal intrabony defects with calcium sulfate implant and barrier versus collagen barrier or open flap debridement alone: a 12-month randomized controlled clinical trial
    Michele Paolantonio
    Department of Periodontology, University G D Annunzio School of Dentistry, Chieti, Italy
    J Periodontol 79:1886-93. 2008
    ....
  39. ncbi Effect of platelet-rich plasma on the healing of intrabony defects treated with Beta tricalcium phosphate and expanded polytetrafluoroethylene membranes
    Ferenc Dori
    Department of Periodontology, Semmelweis University, Budapest, Hungary
    J Periodontol 79:660-9. 2008
    ....
  40. doi The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    Xiaoyan Qi
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 2:295-304. 2009
    ..We addressed the importance of altered Ca(2+) handling, studying underlying mechanisms and consequences...
  41. ncbi Factors associated with periodontal diseases in a dental teaching clinic population in northern Jordan
    Yousef S Khader
    Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    J Periodontol 74:1610-7. 2003
    ..a dental teaching center serving a local population in northern Jordan was performed to identify the factors associated with probing depth (PD), clinical attachment level (CAL), gingival recession (GR), and number of missing teeth (MT).
  42. ncbi The Alternaria alternata melanin biosynthesis gene restores appressorial melanization and penetration of cellulose membranes in the melanin-deficient albino mutant of Colletotrichum lagenarium
    Y Takano
    Laboratory of Plant Pathology, Faculty of Agriculture, Kyoto University, Japan
    Fungal Genet Biol 21:131-40. 1997
    ..The ALM gene transformed the albino mutant (Pks1-) to melanin-producing phenotypes, designated CAL transformants...
  43. ncbi Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia
    C W Cutler
    Department of Periodontics, Baylor College of Dentistry TAMUHSC, Dallas, TX 75266 0677, USA
    J Periodontol 70:1313-21. 1999
    ..The objective of the present study was to determine if diabetes has a similar dysregulatory effect on the gingival response to AP in humans...
  44. ncbi Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronidazole gel
    G S Griffiths
    Department of Periodontology, Eastman Dental Institute and Hospital for Oral Health Care Sciences, University College London, UK
    J Clin Periodontol 27:910-7. 2000
    ..This 2-centre study compared the clinical effects of subgingival scaling (SRP) with SRP plus subgingival application of 25% metronidazole gel, Elyzol (SRP+gel), in patients with chronic adult periodontitis...
  45. ncbi Cathepsins B and L increased during response of periodontal ligament cells to mechanical stress in vitro
    Masaru Yamaguchi
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Sakaecho Nishi, Chiba, Japan
    Connect Tissue Res 45:181-9. 2004
    ..A recent immunocytochemical study demonstrated that cathepsins B (CAB) and L (CAL) were localized in the periodontal ligament (PDL) of the rat molar, and they were expressed in compressed sites ..
  46. pmc Evidence for dimer participation and evidence against channel mechanism in A23187-mediated monovalent metal ion transport across phospholipid vesicular membrane
    B S Prabhananda
    Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400 005, India
    Biophys J 75:1749-58. 1998
    The decay of the pH difference (DeltapH) across soybean phospholipid vesicular membrane by ionophore A23187 (CAL)-mediated H+/M+ exchange (M+ = Li+, Na+, K+, and Cs+) has been studied in the pH range 6-7.6...
  47. ncbi Five-year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration
    Anton Sculean
    Department of Conservative Dentistry and Periodontology, Section of Periodontology, Johannes Gutenberg University, Mainz, Germany
    J Clin Periodontol 31:545-9. 2004
    ..Treatment with enamel matrix proteins (EMD) or guided tissue regeneration (GTR) has been shown to enhance periodontal regeneration. However, until now there are limited data on the long-term results following these treatment modalities...
  48. doi Biomechanical evaluation of an augmented coracoacromial ligament transfer for acromioclavicular joint instability
    Mathias Wellmann
    Department of Orthopaedic Surgery, Hannover Medical School, Hannover, Germany
    Arthroscopy 24:1395-401. 2008
    The purpose of this study was to establish and biomechanically evaluate an augmented coracoacromial ligament (CAL) transfer technique that eliminates the biomechanical drawbacks of the conventional Weaver-Dunn procedure and restores the ..
  49. ncbi Periodontal treatment with an Er: YAG laser compared to scaling and root planing. A controlled clinical study
    F Schwarz
    Department of Periodontology and Conservative Dentistry, University of the Saarland, Homburg, Germany
    J Periodontol 72:361-7. 2001
    ..The aim of the present study was to compare the effectiveness of an Er:YAG laser to that of scaling and root planing for non-surgical periodontal treatment...
  50. ncbi Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis
    P Purucker
    Department of Periodontology and Synoptic Dentistry, University Hospital Charite, Humboldt University at Berlin, Germany
    J Periodontol 72:1241-5. 2001
    ..The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with GAgP...
  51. ncbi The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid
    Nezih Azmak
    Department of Periodontology, Faculty of Dentistry, Ege University, Izmir, Turkey
    J Periodontol 73:608-15. 2002
    ....
  52. ncbi Vitamin D receptor alleles, periodontal disease progression, and tooth loss in the VA dental longitudinal study
    Koji Inagaki
    Department of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, Boston, MA, USA
    J Periodontol 74:161-7. 2003
    ..The relationship between the vitamin D receptor (VDR) genotype and periodontal disease is not known. This study compared periodontal disease progression among polymorphisms of 2 VDR genes in men in the VA Dental Longitudinal Study...
  53. ncbi Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress
    Joanna J Kamma
    J Clin Periodontol 31:894-902. 2004
    ..Cytokine production may also be influenced by smoking and stress leading to an imbalance that disturbs the host-parasite relationship...
  54. ncbi Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus
    Bernard Thebaud
    Department of Pediatrics, Division of Neonatology, University of Alberta, Edmonton, T6G 2J3, AB, Canada
    Pediatr Res 63:176-81. 2008
    ..This paradigm suggests that activation of the voltage-sensitive L-type calcium channels (CaL), which increases cytosolic calcium ([Ca2+]i), is a passive consequence of membrane depolarization...
  55. ncbi Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and xanthan-based chlorhexidine gels in the treatment of chronic periodontitis
    Rajan Gupta
    Department of Periodontics, D A V C Dental College in Yamunanagar, Haryana, India
    J Contemp Dent Pract 9:25-32. 2008
    ....
  56. pmc Diminished treatment response of periodontally diseased patients infected with the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans
    Sheila Cavalca Cortelli
    Department of Periodontology, Dental Research Division, University of Taubate, Taubate, Sao Paulo, Brazil
    J Clin Microbiol 47:2018-25. 2009
    ..Probing depth (PD), clinical attachment level (CAL), and gingival and plaque indices (GI and PI, respectively) were monitored at baseline and at 12 months, along with ..
  57. ncbi Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral and expanded polytetrafluoroethylene membranes
    Ferenc Dori
    Department of Periodontology, Semmelweis University, Budapest, Hungary
    J Periodontol 78:983-90. 2007
    ..This study aimed to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with ABBM and GTR by means of a non-resorbable expanded polytetrafluoroethylene (ePTFE) membrane...
  58. ncbi [Reactivity of Chlamydia pneumoniae strains in the IDEIA CHLAMYDIA test kit designed for detection of Chlamydia trachomatis]
    N Miyashita
    Department of Microbiology, Kawasaki Medical School
    Kansenshogaku Zasshi 67:549-55. 1993
    ..8 x 10(4); and YK-41, 4.0 x 10(4) per assay. The number of EBs of C. trachomatis L2/434/Bu and C. psittaci Cal 10 were 1.0 x 10(3) and 2.7 x 10(4) per assay, respectively. The results demonstrated that the EBs of C...
  59. ncbi Canadian physical therapists' interest in web-based and computer-assisted continuing education
    Sunita Mathur
    School of Rehabilitation Sciences, University of British Columbia, T325 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5
    Phys Ther 85:226-37. 2005
    Distance education via computer-assisted learning (CAL), including Web-based and CD-ROM learning, confers a number of advantages compared with traditional learning methods...
  60. pmc Differential interactions of Na+ channel toxins with T-type Ca2+ channels
    Hui Sun
    Excigen, Inc, Baltimore, MD 21224, USA
    J Gen Physiol 132:101-13. 2008
    Two types of voltage-dependent Ca(2+) channels have been identified in heart: high (I(CaL)) and low (I(CaT)) voltage-activated Ca(2+) channels...
  61. ncbi Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model
    Takahito Yamamoto
    Drug Metabolism Laboratory, Medicinal Development Research Laboratories, Taisho Pharmaceutical Co, Ltd, 403, Yoshino Cho 1 Chome, Kita ku, Saitama shi, Saitama 331 9530, Japan
    Curr Drug Metab 7:135-46. 2006
    ..When the K(i) values (K(i-cal)) obtained from the microtiter plate (MTP) assay and the reported K(i) values (K(i-rep)) for these drugs were used ..
  62. ncbi Isolation of cell wall mutants in Aspergillus nidulans by screening for hypersensitivity to Calcofluor White
    Terry W Hill
    Department of Biology, Rhodes College, Memphis, TN 38112, USA
    Mycologia 98:399-409. 2006
    ..All cal mutants are impaired for sporulation at 30 C or 42 C or both, and in eight of the 10 mutations this sporulation ..
  63. ncbi Impaired healing response of periodontal furcation defects following flap debridement surgery in smokers. A controlled clinical trial
    Leonardo Trombelli
    Research Center for Study of Periodontal Diseases, University of Ferrara, Ferrara, Italy
    J Clin Periodontol 30:81-7. 2003
    ..The purpose of the present parallel-design, controlled clinical trial was to evaluate the treatment outcome of periodontal furcation defects following flap debridement surgery (FDS) procedure in cigarette smokers compared to non-smokers...
  64. ncbi Intermolecular C-H bond activation reactions promoted by transient titanium alkylidynes. Synthesis, reactivity, kinetic, and theoretical studies of the Ti[triple bond]C linkage
    Brad C Bailey
    Molecular Structure Center and School of Informatics, Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Am Chem Soc 129:8781-93. 2007
    ..9(5) at 40 degrees C) with activation parameters DeltaH = 24(7) kcal/mol and DeltaS = -2(3) cal/mol.K, and the post-rate-determining step to be C-H bond activation of benzene (primary KIE = 1...
  65. pmc Proteomic but not enzyme-linked immunosorbent assay technology detects amniotic fluid monomeric calgranulins from their complexed calprotectin form
    Irina A Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, 333 Cedar Street LCI 804, P O Box 208063, New Haven, CT 06520 8063, USA
    Clin Diagn Lab Immunol 12:837-44. 2005
    Four proteomic biomarkers (human neutrophil peptide 1 [HNP1], HNP2 [defensins], calgranulin C [Cal-C], and Cal-A) characterize the fingerprint of intra-amniotic inflammation (IAI)...
  66. doi Viscero-visceral hyperalgesia: characterization in different clinical models
    Maria Adele Giamberardino
    Department of Medicine and Science of Aging, G D Annunzio University of Chieti, Italy
    Pain 151:307-22. 2010
    ..b) irritable bowel syndrome (IBS)+dysmenorrhea (Dys) (T10-L1); (c) dysmenorrhea/endometriosis+urinary calculosis (Cal)(T10-L1); and (d) gallstone+left urinary calculosis (Gs+LCal) (unknown common projection) were compared with ..
  67. ncbi Secondary prevention of low-back pain. A clinical trial
    M Donchin
    Department of Social Medicine, Hebrew University Hadassah School of Public Health and Community Medicine, Jerusalem, Israel
    Spine (Phila Pa 1976) 15:1317-20. 1990
    ..Participants were randomly assigned to one of three groups: a calisthenics program (CAL) for 3 months with biweekly sessions of flexion exercises, a back school program (5 sessions), and a control group...
  68. ncbi Inkoo and Tahyna, the European California serogroup bunyaviruses: sequence and phylogeny of the S RNA segment
    O Vapalahti
    Department of Virology, University of Helsinki, Finland
    J Gen Virol 77:1769-74. 1996
    Inkoo (INK) and Tahyna (TAH) viruses, European representatives of the California serogroup (CAL), genus Bunyavirus, family Bunyaviridae, are transmitted by mosquitoes and frequently infect man...
  69. ncbi Computer assisted learning. A review
    M Schittek
    Department of Periodontology, Centre for Oral Health Sciences, Malmo University, Carl Gustavs väg 34, 214 21 Malmö, Sweden
    Eur J Dent Educ 5:93-100. 2001
    ..Current research indicates that computer connected databases and computer assisted learning (CAL) may enhance learning and provide the clinician with information for decision-making when treating patients...
  70. ncbi Opioids and the apoptotic pathway in human cancer cells
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, H 109, Hershey, PA 17033, USA
    Neuropeptides 37:79-88. 2003
    ..Using three human cancer cell lines: MIA PaCa-2 pancreatic adenocarcinoma, HT-29 colon adenocarcinoma, and CAL-27 squamous cell carcinoma of the head and neck, and OGF and the opioid antagonist naltrexone (NTX) at a dosage (10(..
  71. ncbi A chronology for late prehistoric Madagascar
    David A Burney
    Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA
    J Hum Evol 47:25-63. 2004
    ..Multiple lines of evidence point to the earliest human presence at ca. 2300 14C yr BP (350 cal yr BC)...
  72. ncbi Evaluation of an interactive educational tool for primary care researchers
    Sara Shaw
    Department of Primary Care and Population Sciences, University College London, London, UK
    Med Teach 26:483-6. 2004
    This paper describes an evaluation of a computer-assisted learning (CAL) resource for primary care researchers...
  73. ncbi Inequality of access to surgical specialty health care: why children with government-funded insurance have less access than those with private insurance in Southern California
    Edward C Wang
    Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Pediatrics 114:e584-90. 2004
    ..In California, 3.25 million children depend on Medi-Cal for their health insurance. In Southern California alone, the figure is as high as 1.81 million. However, 9...
  74. ncbi The number of N-point digital discs
    Martin N Huxley
    School of Mathematics, Cardiff University, Cardiff, UK
    IEEE Trans Pattern Anal Mach Intell 29:159-61. 2007
    A digital disc is the set of all integer points inside some given disc. Let {\cal D}_{N} be the number of different digital discs consisting of N points (different up to translation)...
  75. ncbi Effect of platelet-rich plasma on the healing of intra-bony defects treated with a natural bone mineral and a collagen membrane
    Ferenc Dori
    Department of Periodontology, Semmelweis University, Budapest, Hungary
    J Clin Periodontol 34:254-61. 2007
    ..However, at present, it is unknown to what extent the use of PRP may additionally enhance the clinical outcome of the therapy compared with treatment with NBM+GTR...
  76. ncbi Gingival concentrations of interleukin-23 and -17 at healthy sites and at sites of clinical attachment loss
    S Reid Lester
    Department of Periodontics and Preventive Sciences, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Periodontol 78:1545-50. 2007
    ..The presence of interleukin (IL)-23 has not been reported within inflamed gingiva, so we evaluated its concentration within gingiva from normal sites and sites of chronic periodontal disease...
  77. ncbi Ring inversion, structural stability and vibrational assignments of sulfolane c-C4H8SO2 and 3-sulfolene c-C4H6SO2
    Hassan M Badawi
    Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
    Spectrochim Acta A Mol Biomol Spectrosc 70:983-90. 2008
    ..that corresponds to a planar ring but at the MP2 level with a double minimum with a low barrier of about 193 cal mol(-1) to ring planarity in reasonable agreement with experimental results...
  78. doi Patterned imprint mark due to the folded shoulder stock: a possible finding in contact shots from submachine guns
    Markus Grosse Perdekamp
    Institute of Legal Medicine, University Hospital Freiburg, 79104 Freiburg, Germany
    Forensic Sci Int 178:e1-5. 2008
    ..The paper presents the injury pattern in a 36-year-old man who committed suicide with a Scorpion SA Vz 61 submachine gun cal. 7.65mm Browning from former Czechoslovakia.
  79. doi The missing link in the mystery of normal automaticity of cardiac pacemaker cells
    Edward G Lakatta
    National Institutes of Health, National Institute on Aging, Laboratory of Cardiovascular Science, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 1123:41-57. 2008
    ..nonlinear terminal DD and therefore ultimately control the chronotropic state by determining the timing of the I CaL activation that initiates the next AP...
  80. doi Herpes simplex virus seroprevalence among children, adolescents and adults in Greece
    H Papadogeorgakis
    Department of Microbiology, A Sygros Dermatology Hospital, University of Athens, Greece
    Int J STD AIDS 19:272-8. 2008
    ..for type-specific antibodies to HSV-1 and HSV-2 using HerpeSelect IgG ELISA tests (Focus Diagnostics Cypress, Cal, USA). Overall age-adjusted seroprevalence of HSV-1 and HSV-2 was 72.0% and 10.2%, respectively...
  81. pmc Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies
    Hilary Mackay
    Department of Chemistry, Hope College, 35 E 12th Street, P O Box 9000, Holland, MI 49422, USA
    Bioorg Med Chem 16:9145-53. 2008
    ..The heat capacities (DeltaC(p)) were determined to be -116 and -499 cal mol(-1)K(-1), respectively...
  82. doi Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease
    Hong Ren Yu
    Department of Pediatrics, Chang Gung University, Kaohsiung Hsien 833, Taiwan
    Pediatr Cardiol 31:1151-6. 2010
    ..Coronary artery lesions (CAL) are the major complications of KD...
  83. ncbi The effects of gender and obesity on myocardial tolerance to ischemia
    C Clark
    Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Physiol Res 60:291-301. 2011
    ..In separate experiments, 18-week-fed (HCD and CD) rats underwent 45 min in vivo coronary artery ligation (CAL) followed by 2 hours reperfusion. Hearts were stained with TTC and infarct size determined...
  84. doi Projecting the impact of the Affordable Care Act on California
    Peter Long
    Blue Shield of California Foundation, San Francisco, USA peter long blueshieldcafoundation org
    Health Aff (Millwood) 30:63-70. 2011
    ..Enrollment in Medi-Cal, the state's Medicaid program, is expected to increase by 1.7 million people, while 4...
  85. ncbi [Determination of 46 plasticizers in food contact polyvinyl chloride packaging materials and their migration into food simulants by gas chromatography-mass spectrometry]
    Chunhai Guo
    Hebei Entry Exit Inspection and Quarantine Bureau, Shjiazhuang 050051, China
    Se Pu 29:42-8. 2011
    ..The cal-ibration curves were linear in the ranges of 0.1-2.0 mg/L with the correlation coefficients of 0.9910-0. 999 9...
  86. doi Uncovering genetic and molecular interactions among floral meristem identity genes in Arabidopsis thaliana
    Valentina Grandi
    Department of Biomolecular Sciences and Biotechnology, Universita degli Studi di Milano, Via Celoria 26, Milan, Italy
    Plant J 69:881-93. 2012
    ..Genes controlling floral meristem identity include LEAFY (LFY), APETALA1 (AP1), CAULIFLOWER (CAL), LATE MERISTEM IDENTITY 1 (LMI1), SHORT VEGETATIVE PHASE (SVP) and AGAMOUS-LIKE24 (AGL24)...
  87. doi One-step, inexpensive high yield strategy for Candida antarctica lipase A isolation using hydroxyapatite
    Aleksandra Dimitrijević
    Faculty of Chemistry, University of Belgrade, Studentski trg 12, 11000 Belgrade, Serbia
    Bioresour Technol 107:358-62. 2012
    Lipase A from Candida antarctica (CAL A) was purified to apparent homogeneity in a single step using hydroxyapatite (HAP) chromatography. CAL A bound to HAP was eluted with 10mM Na-phosphate buffer, pH 7.0 containing 0.5% Triton X-100...
  88. pmc Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia
    Matthew S Davids
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Blood 120:3501-9. 2012
    ..CLL cells cocultured with stroma were treated with the PI3K δ-isoform inhibitor CAL-101 (GS1101). CAL-101 caused CLL cell de-adhesion, leading to increased CLL cell priming...
  89. pmc Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases
    Ben Davidson
    Division of Pathology, Oslo University Hospital, Norwegian Radium Hospital, N 0424 Oslo, Norway
    Gynecol Oncol 128:364-70. 2013
    The objective of this study is to analyze the expression and clinical role of integrin-linked kinase (ILK), α-parvin, β-parvin and migfilin in advanced-stage serous ovarian carcinoma.
  90. doi Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study
    Birte Holtfreter
    Dept of Restorative Dentistry, Periodontology and Endodontology, University of Medicine, Ernst Moritz Arndt University Greifswald, Greifswald
    Eur Respir J 42:1524-35. 2013
    ..Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth...
  91. doi Nd:YAG laser as an adjunctive treatment to nonsurgical periodontal therapy: a meta-analysis
    Fabrizio Sgolastra
    Department of Life, Health and Environmental Sciences, University of L Aquila, San Salvatore 1, Building Delta 6, 67100, L Aquila, Italy
    Lasers Med Sci 29:887-95. 2014
    ..Weighted mean differences and 95% confidence intervals were calculated for the clinical attachment level (CAL), probing depth (PD), and changes in plaque index (PI) and gingival crevicular fluid (GCF)...
  92. doi Reversible interconversion between a monomeric iridium hydroxo and a dinuclear iridium μ-oxo complex
    Richard J Burford
    Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4
    J Am Chem Soc 136:3256-63. 2014
    ..1(5) kcal mol(-1) and ΔS(‡) = -13(2) cal K(-1)...
  93. doi Pooled safety analysis of calcipotriol plus betamethasone dipropionate gel for the treatment of psoriasis on the body and scalp
    K Kragballe
    Department of Dermatology, Arhus University Hospital, Arhus, Denmark
    J Eur Acad Dermatol Venereol 28:10-21. 2014
    ..The objective was to perform a large-scale assessment of tolerability of fixed combination gel (Cal/BD)...
  94. doi Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects
    Monali Shah
    Department of Periodontics, K M Shah Dental College and Hospital, Vadodara, India
    Cell Tissue Bank 16:371-9. 2015
    ..At baseline, using standardized protocol, recession, probing depths (PD), and clinical attachment levels (CAL) were measured, following which periodontal surgery was carried out, with placement of the respective graft ..
  95. doi QKI-5 suppresses cyclin D1 expression and proliferation of oral squamous cell carcinoma cells via MAPK signalling pathway
    X Fu
    Department of Orthodontics, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Int J Oral Maxillofac Surg 44:562-7. 2015
    ..We found QKI-5 expression to be significantly decreased in the oral cancer cell line CAL-27. QKI-5 overexpression also reduced the proliferation of CAL-27 cells, which correlated with cyclin D1...
  96. doi Establishment and characterization of triple drug resistant head and neck squamous cell carcinoma cell lines
    Sindhu Valiyaveedan Govindan
    Integrated Head and Neck Oncology Research Program, DSRG 5, Mazumdar Shaw Centre for Translational Research, Mazumdar Shaw Medical Foundation, Narayana Health, Bangalore, Karnataka 560099, India
    Mol Med Rep 12:3025-32. 2015
    ..Using two head and neck squamous cell carcinoma cell lines, Hep-2 (larynx) and CAL-27 (oral cavity), the present study sequentially exposed these cells to increasing concentrations of the ..
  97. pmc Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution
    Oleg V Tsodikov
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, 40536 0596, Lexington, KY, USA
    BMC Struct Biol 15:13. 2015
    Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy...
  98. pmc Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1
    Tobias Hilbert
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Mediators Inflamm 2015:948540. 2015
    ..We hypothesized that the combination of structurally different TLR7 ligands exponentiates the resulting immune response...
  99. ncbi Long-term outcome following regenerative periodontal treatment of intrabony defects
    Kanyawat Rattanasuwan
    Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University, Yothi Road, Ratchathewi, Bangkok, 10400, Thailand
    Odontology . 2016
    ..regenerative periodontal therapy of an intrabony defect in terms of tooth survival and clinical attachment level (CAL) stability. The association between failure and patient as well as tooth variables was assessed...
  100. pmc Pre-Clovis occupation 14,550 years ago at the Page-Ladson site, Florida, and the peopling of the Americas
    Jessi J Halligan
    Department of Anthropology, Florida State University, Tallahassee, FL 32306, USA
    Sci Adv 2:e1600375. 2016
    ..Seventy-one radiocarbon ages show that ~14,550 calendar years ago (cal yr B.P.), people butchered or scavenged a mastodon next to a pond in a bedrock sinkhole within the Aucilla River...
  101. pmc Characteristics of coronary arterial lesions in patients with coronary heart disease and hypertension
    Jing xia Zhang
    Department of Cardiology, Tianjin Chest Hospital, Jizhao Road, Jinnan District, Tianjin, 300222 China
    Springerplus 5:1208. 2016
    The aim of this study was to investigate the correlations between risk factors such as hypertension and the complex degrees of coronary arterial lesions (CAL).

Research Grants63

  1. Saliva and Serum Inflammatory Biomarkers in Periodontitis: A Study in Older Women
    Jean Wactawski Wende; Fiscal Year: 2010
    ..examinations were conducted according to standardized protocols to assess indices of oral and periodontal health (CAL, ACH, bleeding, plaque, calculus, tooth loss, DMFT, oral bone density)...
  2. Alexandra M Machikas; Fiscal Year: 2014
    ..Using adult and aged female Fisher 344 rats, a coronary artery ligation (CAL) model of I/R will be used to address the question...
  3. Chicago Endothelial Function Study
    Louise C Hawkley; Fiscal Year: 2010
    ..INITIAL BUDGET PERIOD DIRECT COSTS ONLY PERSONNEL (Applicant organization only) Months Devoted to Project ROLE ON Cal. Acad. Summer INST...
  4. Lisa Ostrin; Fiscal Year: 2016
    ..Austin Roorda (Univ. Cal. Berkeley), who has agreed to give guidance on retinal imaging and image analysis, and 3) Dr. Ronald Harwerth (Univ...
  5. Stimuli promoting the survival of spiral ganglion neurons
    Steven H Green; Fiscal Year: 2011
    ..Physiologi,cal activity and stimulation by cochlear implants consists of impulses of various frequencies...
  6. Sherie L Morrison; Fiscal Year: 2015
    ..and primary cells when used in combination with inhibitors of mTOR (rapamycin or temsirolimus) or PI3 kinase d (CAL-101). B...
  7. TILIA N KIMM; Fiscal Year: 2014
    ..Results of these experiments will also be incorporated into a freely-available model. ..
  8. Collaborative Model Addressing Mental Health in the Perinatal Period
    Cynthia D Connelly; Fiscal Year: 2012
    ..A total of 16 clinics will participate, each serving Medi-Cal CPSP mothers throughout San Diego County...
  9. Vascular Calcium Channel Expression in Hypertension
    Nancy J Rusch; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The L-type Ca2+ (CaL) channels are multi-protein complexes that include a pore- forming 11C subunit and smaller ancillary subunits...
  10. Ian McKeague; Fiscal Year: 2016
    ..The key aim of the project is to develop new methods of statisti- cal inference for finding such genetic loci, leading to the identification of chromosomal regions that are potentially ..
  11. Transporters and Trafficking in Polarized Epithelial Cells
    Mark Donowitz; Fiscal Year: 2013
    ..trafficking of CFTR, its B band, and the mutant (508 will be studied for how the PDZ domain containing proteins CAL and the NHERFs coordinate setting plasma membrane and organellar distribution of CFTR under basal and cAMP-..
  12. Can Medicaid Benefits Reduce Access Disparities for Minority Children &Youth?
    LONNIE ROSCOE SNOWDEN; Fiscal Year: 2012
    ..provided by applicant): The study goal is to examine the aggressive enforcement of Medicaid's (Medi-Cal's) Early Periodic Screening Diagnosis and Treatment program (EPSDT) to learn whether reducing important ..
  13. Paul E Wischmeyer; Fiscal Year: 2014
    ..The intervention group will receive additional protein/energy via PN. This parenteral solution contains 1.2 cal/ml, similar to the EN solution...
  14. Small-Molecule Targeting of CFTR:PDZ Trafficking Interactions
    Dean R Madden; Fiscal Year: 2011
    ..We have now shown that the CFTR-Associated Ligand CAL is implicated in regulating the post-maturational stability of F508-CFTR...
  15. Abul Anisuzzaman; Fiscal Year: 2014
    ..The proposal also describes progress CAL has made in providing support to the FERN Chemistry Program to date...
  16. Adaptations to robotic resistance during treadmill training in SCI rats
    Ray D de Leon; Fiscal Year: 2013
    ..The PI's laboratory at Cal State LA has been studying robotic-applied forces in the rodent models of spinal cord injury and thus has all the ..
  17. Mechanical Stress and the Heat-Treatment of Soft Tissue
    JAY HUMPHREY; Fiscal Year: 2003
    ..of multiaxial stresses on the thermal process as well as the effects of thermal damage on the multiaxial mechani-cal properties. No such data are available...
  18. Breast Cancer Care and Survivorship in Underserved Women
    Rose C Maly; Fiscal Year: 2010
    ..The Breast and Cervical Cancer Treatment Program (BCCTP) is a federally legislated Medicaid ("Medi-Cal" in California) program to address the needs of low-income, un- and under-insured women with breast cancer...
  19. Adolescent Health Literacy: Improving Use of Preventive Health Services
    MICHAEL LEE PRELIP; Fiscal Year: 2010
    ..We will engage beneficiaries of public health insurance namely Medicaid (Medi-cal) and SCHIP (Healthy Families) clients whose health care is managed by Health Net...
  20. Amybeth Cohen; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The mission of the Cal State Fullerton MARC U*STAR Program is to prepare promising minority students for graduate school and a research career in biomedical or behavioral science...
  21. Improving Quantitative Skills of Life Science Majors at Cal State Los Angeles
    James P Henderson; Fiscal Year: 2012
    ..By applying new pedagogical approaches, such as the scientific teaching approach, we expect that students will improve their quantitative skills and better understand the connections between the scientific disciplines. ..
  22. Erick Guerrero; Fiscal Year: 2014
    ..e., leadership, readiness for change, Medi-Cal billing) in mediating the effect of Medicaid expansion (referred as Medi-Cal in California) on service delivery (i...
  23. GREGORY GEORGE ZAHARCHUK; Fiscal Year: 2016
    ..acute ischemic stroke, and the presence of good collaterals has been linked to improved clinical and radiologi- cal outcome measures both with and without successful recanalization...
  24. CFTR/REGULATION OF CL SECRETION IN NORMAL AND CF AIRWAYS
    William Guggino; Fiscal Year: 2009
    ..We discovered a new protein, CAL that tethers CFTR within the Golgi and targets CFTR for degradation in the lysosome...
  25. MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
    Donald R Menick; Fiscal Year: 2013
    ..status in an animal model of pathological pressure overload hypertrophy, with a parallel model of physiologi- cal volume overload hypertrophy serving as a control for any effects of growth per se...
  26. Jun Qin; Fiscal Year: 2016
    ..proposal will focus on investigating an emerging regulatory machinery, which involves filamin as a "brake" and migfilin as a "booster" for integrin activation...
  27. CARLOS GABRIEL GUTIERREZ; Fiscal Year: 2016
    ..We propose an integrated four-year institutional program that assists talented Cal State LA science students in becoming outstanding within their science discipline, supports their motivation for a ..
  28. Northern California Healthy Indian Communities/University of California, Davis Me
    DENNIS MICHAEL STYNE; Fiscal Year: 2010
    ..5. Develop the Nor-Cal Tribal Institutional Review Board, to review and determine the relevance of research projects which are identified ..
  29. Sally J Rogers; Fiscal Year: 2016
    ..a sample of 108 young children with ASD, ages 15-30 months, will be enrolled in one of three national sites (Univ Cal Davis, Vanderbilt, Univ...
  30. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..mono) fat; 6 percent polyunsaturated (poly) fat, with 150 mg of cholesterol/1000 calories and 10 g/1000 cal. of fiber)...
  31. Replacement Ocular Battery (ROBatt)
    GEORGE L DEGEORGE; Fiscal Year: 2011
    ..and Toxicology of Chemicals (ECETOC) data bank, including Corrosive (EEC R41, GHS/EPA Cat 1), Severe (EEC R36, GHS CaL 2, HMIS 2), Moderate (EPA Cat. 3, HMIS 2), Mild (HMIS 1) and Non-irritating (EPA Cat 4, HMIS 0)...
  32. Robert L Vellanoweth; Fiscal Year: 2016
    ..D. programs at major research universities. These institutions are California State University, Los Angeles (Cal State LA), a minority institution, which awards the M.S. as its highest science degree, and two Ph.D...
  33. A Continuum Model for Cartilage Growth Biomechanics
    STEPHEN KLISCH; Fiscal Year: 2009
    ..proposed research are to enhance health related research in our predominantly undergraduate engineering program at Cal Poly, San Luis Obispo and to engage undergraduate students in biomedical research to help prepare them for careers ..
  34. Regulation of Vascular Tone and Ca channels by Integrins
    Michael Davis; Fiscal Year: 2009
    ..vascular tone: 1) mechanotransduction of intravascular pressure through the voltage-gated, L-type Ca2+ channel (CaL), which is the primary Ca2+ entry pathway in VSM, and 2) the effects of biologically active matricryptins (i.e...
  35. LINDA M TUNSTAD; Fiscal Year: 2016
    California State University Los Angeles (Cal State LA) Los Angeles City College, East Los Angeles College, and Pasadena City College have established a very successful collaborative for developing the careers of talented community ..
  36. TAMI FOY; Fiscal Year: 2016
    ..By achieving the above aims, Cal State Fullerton will provide efficient, consistent, and friendly customer service to its faculty and students, ..
  37. CARLOS GABRIEL GUTIERREZ; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The California State University Los Angeles (Cal State LA) MBRS RISE project has been very successful in developing the careers of talented minority students who have continued into PhD...
  38. Integration of Biomedical Research into Education of Future PhD Candidates
    JILL ADLER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The long-range goal of the Cal Poly Pomona RISE (Research Initiative for Scientific Enhancement) is to increase the number of underrepresented minority students who complete Ph.D...
  39. Physiology of LGR7 and LGR8 in Gonadal Tissues
    Aaron Hsueh; Fiscal Year: 2007
    ..relaxin is produced by ovarian luteal cells whereas INSL3 is produced by testis Leydig cells as well as ovarian the cal and luteal cells, their physiological roles in the gonads are unclear...
  40. La Jolla Immunology Conference
    STEPHEN PHILIP SCHOENBERGER; Fiscal Year: 2013
    ..The La Jolla Institute for Allergy and Immunology as well as participants from UC Irvine, UC Riverside, UCLA, USC, Cal-Tech, and Cedars-Sinai Medical Center...
  41. PREGNANT ADDICTS AND OFFSPRING: EVALUATING INTERVENTION
    Judy Howard; Fiscal Year: 1993
    ..Of 2 recruited English-speaking, Medi-Cal-eligible, non-teenaged substance-abusing women, 90 will be randomly assigned to the experimental group receiving ..
  42. DNA CONFORMATION AND ENEDIYNE TARGET RECOGNITION
    Peter Dedon; Fiscal Year: 1999
    ..and four enediyne antitumor antibiotics: neocarzinostatin (NCS), esperamicin A1 (ESP A1), calicheamicin gamma1[I] (CAL), and C-1027...
  43. Philip Williams; Fiscal Year: 2014
    ..tial anti-Alzheimer drug leads will be evaluated in a series of biochemical assays to assess parameters criti- cal to CNS drug development...
  44. ETIOLOGY OF DISORDERS OF OLFACTORY EPITHELIA
    Joel Maruniak; Fiscal Year: 1991
    ..They further point the way to development of sorely needed clini- cal interventions that could prevent or ameliorate some types of human olfactory dysfunction...
  45. MECHANISMS OF SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS
    Robert Malenka; Fiscal Year: 1993
    ..It has been proposed that the induction of LTP in the CAl region of the hippocampus requires activation of postsynaptic N-methyl-D-aspartate (NMDA) receptors and concomitant ..
  46. PHASE III STUDY OF FENRETINIDE IN BLADDER CARCINOFENESIS
    Scott Lippman; Fiscal Year: 2001
    ..includes superficial (Ta) primary or recurrent (>1 year after primary) bladder tumors not requiring intraves'cal therapy...
  47. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2005
    ..CaMKII), or the g or B isoform of protein kinase C (PKC) is deleted (knocked out) specifically and separately in CAl or CA3 pyramidal cells of the hippocampus...
  48. METABOLIC STUDIES OF PARENTERAL NUTRITION IN INFANTS
    RALPH DELL; Fiscal Year: 1980
    ..This project consists of four subprojects. The objective of the first is to determine the effect of both quantity (65 Cal/kg.d vs. 130 Cal/kg.d) and quality (0.5 gm/kg.d vs. 3 gm/kg...
  49. Evaluation of California Initiatives to Reduce Violence*
    Corinne Peek Asa; Fiscal Year: 2004
    ..The first initiative was Cal/OSHA's 1993 release of "Guidelines for Security and Safety of Health Care and Community Service Workers...
  50. Ovarian Steroid Hormones and Hippocampal Plasticity
    William Levy; Fiscal Year: 2004
    ..LTP) and long-term depression (LTD) of the CA3-CA1 synapses and 2) estradiol increases the excitability of CAl pyramidal neurons...
  51. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Alcino Silva; Fiscal Year: 2004
    ..The specific aims of this proposal are: 1- To determine the role of a-CaMKII in either CAl, CA3 or dentate gyrus in learning and memory...
  52. DEVELOPMENT OF A CHRONIC ARTIFICIAL LUNG
    Bartley Griffith; Fiscal Year: 2001
    ..biocompatibility, and design have enabled us to develop a promising prototype (chronic artificial pump-lung, CAL)...
  53. GENE TARGETING APPROACHES TO LEARNING AND MEMORY STUDIES
    Joshua Trachtenberg; Fiscal Year: 2006
    ..The specific aims of this proposal are: 1- To determine the role of a-CaMKII in either CAl, CA3 or dentate gyrus in learning and memory...
  54. The Connecticut Longitudinal Study in the Fourth Decade
    Sally E Shaywitz; Fiscal Year: 2010
    ..Directly responsive to the RFA cal for: "basic research onthe neurobiological underpinnings of reading fluency, vocabulary development, reading ..
  55. Regulation of Osteoclast Activity by Calcium and cGMP
    Harry C Blair; Fiscal Year: 2010
    ..This will include studies of rearrangement of membrane- attachment proteins in response to NO, including VASP, migfilin and the alph-v-beta3 integrin...
  56. DIETARY CHANGE THROUGH BLACK CHURCHES
    Ken Resnicow; Fiscal Year: 2000
    ..MCI=Tx1) that will include culturally sensitive written materials, audio tapes, a video, and one telephone booster cal; Group 3 will receive the same intervention as Group 2, plus three additional telephone calls (MCI+3T=Tx2)...
  57. REGULATION OF BRAIN GLUTAMATE RECEPTORS
    Markus Kessler; Fiscal Year: 1991
    ..Membranes will then be prepared from the excised CAl fields...
  58. GLOBAL RESEARCH TRAINING FOR RURAL CALIFORNIA MINORITIES
    SUSAN OPAVA; Fiscal Year: 2003
    ..This application builds on the successes of the current MIRT program at California Polytechnic State University (Cal Poly)...
  59. UPGRADING ANIMAL CARE FACILITIES
    STEVEN WICKLER; Fiscal Year: 1992
    California State Polytechnic University (Cal Poly) has had a leading role in the establishment of a comprehensive animal care program within the California State University (a total of 20 schools)...
  60. Cal State LA COR Honors Program
    Siyon Rhee; Fiscal Year: 2006
    California State University Los Angeles (Cal State LA), a minority institution with a long tradition of success in developing the careers of minority Americans in the biomedical sciences, proposes to establish an Honors Undergraduate ..
  61. Early Memory Development: Mechanisms and Methods
    Patricia Bauer; Fiscal Year: 2007
    ..neuroscience, developmental neuroscience, and the brain imaging technique of high-density electrophysiologi cal (ERP) recording...
  62. Cal State LA Biomedical PREP
    Carlos Gutierrez; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): California State University Los Angeles (Cal State LA), a minority institution offering the MS as its highest degree, and with a long tradition of success in developing the careers of ..
  63. SCORE PROGRAM AT CAL POLY POMONA
    DONALD HOYT; Fiscal Year: 2007
    The SCORE Program at Cal Poly Pomona is designed to significantly improve the research capabilities of the University with the ultimate objectives of increasing the number of underrepresented minority biomedical scientists...