FasL

Summary

Gene Symbol: FasL
Description: Fas ligand
Alias: ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, tumor necrosis factor ligand superfamily member 6, CD95 ligand, Fas ligand (TNF superfamily, member 6), apoptosis (APO-1) antigen ligand 1, apoptosis antigen ligand, fas antigen ligand, mutant tumor necrosis factor family member 6, tumor necrosis factor ligand 1A
Species: human

Top Publications

  1. doi The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8
    Florent Dufour
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM and Institut du cancer de Montréal, Hopital Notre Dame, 1560 Sherbrooke Est, Montreal, QC, Canada
    Apoptosis 16:256-71. 2011
  2. pmc Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1α, and interleukin-1β in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis
    Andreas Borkenstein
    Department of Ophthalmology, Medical University of Graz, Austria
    Mol Vis 19:2306-11. 2013
  3. doi Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma
    Rong Miao Zhou
    Department of Molecular Biology, the Fourth Affiliated Hospital of Hebei Medical University, Hebei Province, China
    J Gastroenterol Hepatol 25:555-61. 2010
  4. doi Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells
    Ku Chung Chen
    Institute of Biomedical Sciences, National Sun Yat Sen University Kaohsiung Medical University Joint Research Center, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    J Cell Biochem 109:245-54. 2010
  5. ncbi Fas-1377A/G and FasL-844 T/C gene polymorphisms and epithelial ovarian cancer
    Uzay Gormus
    Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Istanbul, Turkey
    Anticancer Res 27:991-4. 2007
  6. doi Polymorphisms in the apoptosis-associated genes FAS and FASL and risk of oral cancer and malignant potential of oral premalignant lesions in a Taiwanese population
    Li Hsuan Wang
    Division of Molecular Diagnosis, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Oral Pathol Med 39:155-61. 2010
  7. pmc The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse
    Clare Jolly
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS Pathog 7:e1002226. 2011
  8. doi AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells
    Jung Yeon Lee
    Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul 130 701, Republic of Korea
    Cell Signal 24:1195-207. 2012
  9. ncbi Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells
    Y S Jung
    Research Center for Biomedicinal Resources and Division of Life Science, Paichai University, Taejon, Korea 302 735
    Biochem Biophys Res Commun 288:420-6. 2001
  10. ncbi A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand
    Geert van Loo
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, University of Ghent, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Cytokine 22:62-70. 2003

Detail Information

Publications259 found, 100 shown here

  1. doi The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8
    Florent Dufour
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM and Institut du cancer de Montréal, Hopital Notre Dame, 1560 Sherbrooke Est, Montreal, QC, Canada
    Apoptosis 16:256-71. 2011
    ..against apoptosis induced by the death receptor (DR) ligands tumor necrosis factor-alpha- (TNFα) and Fas ligand (FasL) by interrupting DR-mediated signaling at, or upstream of, caspase-8 activation...
  2. pmc Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1α, and interleukin-1β in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis
    Andreas Borkenstein
    Department of Ophthalmology, Medical University of Graz, Austria
    Mol Vis 19:2306-11. 2013
    Various cytokines, including tumor necrosis factor-alpha (TNF-α), Fas ligand (FasL), interleukin-1α (IL-1α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), contribute to the pathogenesis of primary open angle glaucoma (POAG)...
  3. doi Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma
    Rong Miao Zhou
    Department of Molecular Biology, the Fourth Affiliated Hospital of Hebei Medical University, Hebei Province, China
    J Gastroenterol Hepatol 25:555-61. 2010
    The FAS and FASL system play an important role in regulating apoptotic cell death...
  4. doi Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells
    Ku Chung Chen
    Institute of Biomedical Sciences, National Sun Yat Sen University Kaohsiung Medical University Joint Research Center, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    J Cell Biochem 109:245-54. 2010
    ..Moreover, PLA(2) treatment increased Fas and FasL protein expression...
  5. ncbi Fas-1377A/G and FasL-844 T/C gene polymorphisms and epithelial ovarian cancer
    Uzay Gormus
    Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Istanbul, Turkey
    Anticancer Res 27:991-4. 2007
    The Fas receptor is known to be widely expressed in various tissues and FasL is highly expressed on cells of the immune system and also on cells of immune-privileged areas such as the eyes and brain...
  6. doi Polymorphisms in the apoptosis-associated genes FAS and FASL and risk of oral cancer and malignant potential of oral premalignant lesions in a Taiwanese population
    Li Hsuan Wang
    Division of Molecular Diagnosis, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Oral Pathol Med 39:155-61. 2010
    Our aim was to measure the relationship of FAS (-1377G>A and -670A>G), FASL (-844C>T) gene variants and risk of oral cancer.
  7. pmc The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse
    Clare Jolly
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS Pathog 7:e1002226. 2011
    ..termed secretory lysosomes (SL) and we show that the HIV-1 envelope glycoprotein (Env) localizes with CTLA-4 and FasL in SL-related compartments and at the VS...
  8. doi AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells
    Jung Yeon Lee
    Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul 130 701, Republic of Korea
    Cell Signal 24:1195-207. 2012
    ..cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression...
  9. ncbi Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells
    Y S Jung
    Research Center for Biomedicinal Resources and Division of Life Science, Paichai University, Taejon, Korea 302 735
    Biochem Biophys Res Commun 288:420-6. 2001
    ....
  10. ncbi A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand
    Geert van Loo
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, University of Ghent, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Cytokine 22:62-70. 2003
    ..In contrast, Fas ligand (FasL)-induced death cannot be overcome in bcl-2 transgenic mice, indicating that anti-Fas antibodies do not reliably ..
  11. ncbi Apoptotic death of infiltrating cells in human cardiac allografts is regulated by IL-2, FASL, and FLIP
    H A de Groot-Kruseman
    Department of Internal Medicine, University Medical Center Utrecht, The Netherlands
    Transplant Proc 36:3143-8. 2004
    In vitro studies have shown that apoptotic cell death is triggered by a IL-2-dependent activation of the Fas-FasL pathway and that this pathway can be inhibited by FLIP.
  12. ncbi Fas/Fas-Ligand pathway is impaired in patients with type 2 diabetes. Influence of hypertension and insulin resistance
    E Cosson
    Department of Diabetology Endocrinology Nutrition, AP HP, Paris Nord University, Jean Verdier Hospital, and Laboratory of Nutrition and Metabolic Diseases, Paris Nord University, Bondy, France
    Diabetes Metab 31:47-54. 2005
    ....
  13. doi Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin
    Jong Gwang Kim
    Department of Oncology Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Jung Gu, Daegu, Korea
    Cancer Chemother Pharmacol 64:953-60. 2009
    ..The present study analyzed the polymorphisms of apoptosis-related genes and their impact on the response to chemotherapy and survival of patients with colorectal cancer...
  14. doi Functions of Tat: the versatile protein of human immunodeficiency virus type 1
    Bizhan Romani
    Division of Medical Virology, Department of Pathology, University of Stellenbosch, Tygerberg 7505, South Africa
    J Gen Virol 91:1-12. 2010
    ..Due to its pivotal role in viral replication and in disease pathogenesis, Tat and the cellular pathways targeted by Tat are potential targets for new anti-HIV drugs...
  15. ncbi A role for CD95 ligand in preventing graft rejection
    D Bellgrau
    Department of Immunology, University of Colorado School of Medicine, Denver 80262, USA
    Nature 377:630-2. 1995
    ..Further analysis of testis showed that CD95 ligand messenger RNA is constitutively expressed by testicular Sertoli cells, and that Sertoli cells from normal mice, ..
  16. ncbi Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin
    T Okura
    Division of Molecular Medicine, The University of Texas Houston Health Science Center 77030, USA
    J Immunol 157:4277-81. 1996
    ..Sentrin is a novel protein of 101 amino acids with homology to ubiquitin, Nedd8, and a Saccharomyces cerevisiae protein, Smt3. When overexpressed, sentrin provides protection against both anti-Fas/APO-1 and TNF-induced cell death...
  17. pmc Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression
    Wen Horng Wang
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 1246, USA
    Mol Cell Biol 24:10352-65. 2004
    ..kinase and JNK pathways is sustained, inducing the transcription of the death receptor family genes encoding Fas/FasL and tumor necrosis factor receptor 1 (TNFR1)/TNF-alpha and the p53-regulated Bax and Noxa genes...
  18. pmc HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation
    Karuppiah Muthumani
    University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine 422 Curie Blvd, Philadelphia, PA 19104, USA
    Blood 106:2059-68. 2005
    ..This effect is manifested in part through up-regulation of the death receptor Fas ligand (FasL) by HIV-1 negative factor (Nef), leading to bystander damage...
  19. pmc Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis
    Khalid Bajou
    Division of Hematology Oncology, Department of Pediatrics, University of Southern California and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Cancer Cell 14:324-34. 2008
    ..Here we provide evidence that PAI-1 is essential to protect endothelial cells (ECs) from FasL-mediated apoptosis...
  20. pmc Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis
    Vladimir N Ivanov
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 281:1840-52. 2006
    ....
  21. pmc Expression of Fas ligand and caspase-3 contributes to formation of immune escape in gastric cancer
    Hua Chuan Zheng
    The Fourth Lab Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 9:1415-20. 2003
    To study the role of Fas ligand (FasL) and Caspase-3 expression in carcinogenesis and progression of gastric cancer and molecular mechanisms of relevant immune escape.
  22. ncbi Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation
    Ya Huey Chen
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan, Republic of China
    Thromb Haemost 95:668-77. 2006
    ..Furthermore, K1-3, K1-4 or K1-4.5 increased the expression of p53 protein and its downstream effectors, enhanced FasL-mediated signaling pathways, and decreased activation of AKT...
  23. ncbi Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
    T Brunner
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, California 92037
    Nature 373:441-4. 1995
    ..Because T-cell receptor ligation can induce apoptosis in a single T hybridoma cell, we suggest that the Fas/Fas-ligand interaction can induce cell death in a cell-autonomous manner...
  24. ncbi Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2
    F Hashimoto
    Department of Pediatrics, North Shore University Hospital New York University School of Medicine, Manhasset 11030, USA
    Blood 90:745-53. 1997
    ....
  25. ncbi Fas and Fas ligand gene polymorphisms in primary Sjögren's syndrome
    A I Bolstad
    Broegelmann Research Laboratory, Center for Medical Genetics and Molecular Medicine, Institute of Medicine, Haukeland University Hospital, Bergen, Norway
    J Rheumatol 27:2397-405. 2000
    To screen for polymorphisms in the apoptosis regulating Fas and Fas ligand (FasL) genes in patients with primary Sjögren's syndrome (SS), and to explore associations with susceptibility to the disease.
  26. pmc Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis
    Julie Guillermet
    Institut National de la Santé et de la Recherche Médicale INSERM U531, Institut Federatif de Recherche IFR 31, Centre Hospitalier Universitaire CHU Rangueil, France
    Proc Natl Acad Sci U S A 100:155-60. 2003
    ..1- +/- 1.5-fold. Apoptosis in BxPC-3 cells mediated by TNF-related apoptosis-inducing ligand (TRAIL) and CD95L was likewise increased 2.3- +/- 0.5-fold and 7.4- +/- 2.5-fold, respectively...
  27. pmc Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease
    J Wu
    Department of Medicine, The University of Alabama at Birmingham 35294, USA
    J Clin Invest 98:1107-13. 1996
    ..The apoptosis genes, fas and fas ligand (fasL), are candidate contributory genes in human SLE, as mutations of these genes result in autoimmunity in several ..
  28. ncbi Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand
    Tracy Vargo-Gogola
    Department of Cancer Biology, Vanderbilt University, 736 PRB 23rd and Pierce, Nashville, TN 37232 6840, USA
    Arch Biochem Biophys 408:155-61. 2002
    ..However, there are contradictory reports that the soluble form of FasL is inactive or anti-apoptotic, resulting in significant controversy in the literature...
  29. ncbi Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    Immunity 18:655-64. 2003
    ..We suggest that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways...
  30. ncbi Genomic analysis of Fas and FasL genes and absence of correlation with disease progression in AIDS
    A Vasilescu
    Centre National de Genotypage, 2 rue Gaston Cremieux, 91000 Evry, France
    Immunogenetics 56:56-60. 2004
    ..acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of Fas and Fas ligand ( FasL) genes...
  31. pmc CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells
    Bryan C Barnhart
    The Ben May Institute for Cancer Research, Committee on Immunology, The University of Chicago, Chicago, IL 60637 5420, USA
    EMBO J 23:3175-85. 2004
    ..Despite its apoptotic potential, most human tumors are refractory to the cytotoxic effects of CD95 ligand. We now show that CD95 stimulation of multiple apoptosis-resistant tumor cells by CD95 ligand induces increased ..
  32. ncbi Genetic polymorphisms of FAS and FASL (CD95/CD95L) genes in cervical carcinogenesis: An analysis of haplotype and gene-gene interaction
    Hung Cheng Lai
    Department of Obstetrics and Gynecology, Tri Service General Hospital, 325 Section 2 Cheng Gung Road, Taipei 114, Taiwan, ROC
    Gynecol Oncol 99:113-8. 2005
    ..The present study examines the hypothesis that genetic polymorphisms in FAS and FAS ligand genes, alone or in combination, are associated with cervical carcinogenesis...
  33. ncbi Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients
    Milena Nasi
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, Via Campi 287, Modena, 41100, Italy
    Immunogenetics 57:628-35. 2005
    Fas and Fas ligand (FasL) are the main genes that control cell death in the immune system. Indeed, they are crucial for the regulation of T lymphocyte homeostasis because they can influence cell proliferation...
  34. pmc The role of receptor internalization in CD95 signaling
    Kyeong Hee Lee
    Department of Immunology, Genentech Inc, South San Francisco, CA 94080, USA
    EMBO J 25:1009-23. 2006
    ..In this study, we demonstrate a general requirement of receptor internalization for CD95 ligand-mediated DISC amplification, caspase activation and apoptosis in type I cells...
  35. ncbi Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Pharmacogenet Genomics 16:253-63. 2006
    ..In conclusion, genetic variants in the FAS and FASLG genes may contribute to the etiology of CMM in the general population, particularly in those with a low risk of sunlight-induced CMM...
  36. ncbi ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
    M Schulte
    Biochemical Institute, Christian Albrecht University, Kiel, Germany
    Cell Death Differ 14:1040-9. 2007
    The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity...
  37. ncbi Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer
    Emma L Ivansson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Int J Cancer 121:2451-7. 2007
    ..V64I; Interleukin 4 receptor alpha (IL-4R) I75V, S503P and Q576R; Interleukin 10 (IL-10) -592; and Fas ligand (FasL) -844...
  38. ncbi Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin
    V Minas
    Laboratory of Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Crete, Heraklion, Greece
    Mol Hum Reprod 13:663-73. 2007
    ..Here, we examined the hypothesis that the expression of the proapoptotic Fas/FasL system at the implantation site is impaired in abortions...
  39. ncbi Polymorphisms of death pathway genes FAS and FASL and risk of premalignant gastric lesions
    Ping I Hsu
    Division of Gastroenterology and General Medicine, Department of Medicine, Kaohsiung Veterans General Hospital and National Yang Ming University, Kaohsiung, Taiwan, R O C
    Anticancer Res 28:97-103. 2008
    ..The aim of this study was to investigate whether functional polymorphisms of death pathway genes (FAS and FASL) are associated with the development of gastric atrophy and intestinal metaplasia.
  40. doi Functional variants in cell death pathway genes and risk of pancreatic cancer
    Ming Yang
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Clin Cancer Res 14:3230-6. 2008
    Fas-Fas ligand (FasL)-mediated death pathway is important in the life and death of immune cells and, therefore, influences immune surveillance of carcinogenesis...
  41. doi Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer
    Jae Yong Park
    Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    Clin Cancer Res 15:1794-800. 2009
    This study was conducted to investigate the impact of functional polymorphisms in the FAS and FASL genes on the survival of early stage non-small cell lung cancer (NSCLC) patients.
  42. pmc The FAS ligand promoter polymorphism, rs763110 (-844C>T), contributes to cancer susceptibility: evidence from 19 case-control studies
    Zhizhong Zhang
    Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China
    Eur J Hum Genet 17:1294-303. 2009
    The potentially functional polymorphism, rs763110 (-844C>T), in the promoter region of the FAS ligand (FASL) gene, has been implicated in cancer risk, but individually published studies show inconclusive results...
  43. doi Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death
    E Lafont
    Cancer Department, U858 INSERM, Equipe 14, BP84225, 31432 Toulouse Cedex 4, France
    Cell Death Differ 17:642-54. 2010
    ..In this study, we show that in human leukemia Jurkat cells, which express mainly SMS1, Fas ligand (FasL) treatment inhibited SMS activity in a dose- and time-dependent manner before nuclear fragmentation...
  44. pmc Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 28:2445-51. 2010
    ..However, how multiple factors jointly affect EA risk remains unclear...
  45. pmc Fas ligand mediates activation-induced cell death in human T lymphocytes
    M R Alderson
    Immunex Research and Developmental Corporation, Seattle, Washington 98101
    J Exp Med 181:71-7. 1995
    ..Fas-L antagonists inhibited AICD of T cell clones and staphylococcus enterotoxin B (SEB)-specific T cell lines. The data indicate AICD in previously stimulated T cells is mediated by Fas/Fas-L interactions...
  46. pmc Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    F C Kischkel
    Tumor Immunology Program, German Cancer Center, Heidelberg, Germany
    EMBO J 14:5579-88. 1995
    ..Moreover, no APO-1-CAP association was found in the APO-1+, anti-APO-1-resistant pre-B cell line Boe. Our data suggest that in vivo CAP1-4 are the APO-1 apoptosis-transducing molecules...
  47. ncbi Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
    P Schneider
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    J Biol Chem 272:18827-33. 1997
    The death-inducing receptor Fas is activated when cross-linked by the type II membrane protein Fas ligand (FasL)...
  48. ncbi Separate domains of the human fas ligand dictate self-association and receptor binding
    J R Orlinick
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, USA
    J Biol Chem 272:32221-9. 1997
    ..The Fas ligand (FasL), a member of the tumor necrosis factor family of ligands, is a 40-kilodalton type II transmembrane protein which ..
  49. ncbi Death receptors: signaling and modulation
    A Ashkenazi
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 281:1305-8. 1998
    ..Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery...
  50. pmc Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
    Martin R Sprick
    Division for Apoptosis Regulation, Tumour Immunology Program, DKFZ, Heidelberg, Germany
    EMBO J 21:4520-30. 2002
    ..Finally, we demonstrate that caspase-10 is cleaved during CD95-induced apoptosis of activated T cells. These results show that caspase-10 activation occurs in primary cells, but that its function differs from that of caspase-8...
  51. pmc Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death
    Min Li-Weber
    Tumor Immunology G0300, German Cancer Research Center, Heidelberg, Germany
    J Clin Invest 110:681-90. 2002
    ..Expression of the CD95 (APO-1/Fas) ligand (CD95L) is critically involved in activation-induced cell death (AICD) of activated T cells...
  52. ncbi Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease
    Bettina J Stuck
    Department of Internal Medicine I, University Hospital Frankfurt am Main, Germany
    Hum Immunol 64:285-9. 2003
    ..Whereas in Hashimoto's thyroiditis FasL expression causes thyrocytes to undergo apoptosis, additional anti-apoptotic molecules appear to protect these ..
  53. ncbi CTLA-4. FasL induces alloantigen-specific hyporesponsiveness
    Michal Dranitzki Elhalel
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 170:5842-50. 2003
    ..Fas ligand (FasL), that has the inherent capacities to tether the T cell inhibitor FasL (CD95 ligand) to the surfaces of B7 (CD80 and CD86)-positive APC (via CTLA-4:B7 interaction), and in so doing, to ..
  54. ncbi Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts
    Ueli Nachbur
    Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstr 31, 3010 Bern, Switzerland
    Blood 107:2790-6. 2006
    ..Here, we now provide evidence that Fas ligand is constitutively localized in lipid rafts of FasL transfectants and primary T cells...
  55. ncbi Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer
    Bailin Zhang
    Center of Breast Diseases and Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 28:1067-73. 2007
    The FAS-FASL system plays crucial role in counterattack of cancer cell against immune system...
  56. ncbi The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells
    V Kirkin
    Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, Paul Ehrlich Strasse 42 44, 60596 Frankfurt, Germany
    Cell Death Differ 14:1678-87. 2007
    Fas ligand (FasL) is a type II transmembrane protein belonging to the tumor necrosis factor family. Its binding to the cognate Fas receptor triggers the apoptosis that plays a pivotal role in the maintenance of immune system homeostasis...
  57. ncbi Fas/Fas ligand gene polymorphism in patients with papillary thyroid cancer in the Turkish population
    M Erdogan
    Department of Endocrinology and Metabolism Disease, Ege University Medical School, Bornova, Izmir, Turkey
    J Endocrinol Invest 30:411-6. 2007
    Fas ligand (FasL) is an apoptotic agent and a member of tumor necrosis factor (TNF) family. FasL exists in cytotoxic T lymphocyte (CTL) and natural killer (NK) cells, and it is increased in tumor cell membrane...
  58. ncbi Aqueous humor levels of soluble Fas and Fas-ligand in patients with primary open angle and pseudoexfoliation glaucoma
    Mohammad Reza Razeghinejad
    Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    Iran J Immunol 4:215-9. 2007
    ..In patients with primary open angle glaucoma the number of trabecular meshwork cells is decreased. Death of the trabecular meshwork cells may be a result of apoptosis...
  59. doi FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China
    Meilin Wang
    Department of Molecular and Genetic Toxicology, Cancer Center, Nanjing Medical University, 140 Hanzhong Road, Nanjing, China
    Biochem Genet 47:559-68. 2009
    ..We found that the FAS and FASL genotypes and the FAS haplotypes had no significant associations with risk of gastric cancer...
  60. doi Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans
    Hyun Jeong Kim
    Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun Gun, Chonnam, Republic of Korea
    DNA Cell Biol 29:619-24. 2010
    Fas and Fas ligand (FasL) polymorphisms in the promoter regions influence transcriptional activities. The interaction of these two genes plays a crucial role in apoptotic cell death regulation...
  61. doi Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma
    Jian Zhu
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, China
    Mol Carcinog 49:810-7. 2010
    The FAS/FAS ligand (FASL) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis...
  62. pmc Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians
    Juozas Kupcinskas
    Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania
    BMC Med Genet 12:112. 2011
    ..between the presence of gastric cancer (GC) and high risk atrophic gastritis (HRAG) and polymorphisms of genes encoding Angiotensin converting enzyme (ACE), Nod-like receptor 1 (NOD1), Toll-like receptor 4 (TLR4) and FAS/FASL.
  63. doi Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: gene-gene interactions in high-risk Indians
    Mohammad Yahya Karimi
    Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Cancer Invest 31:1-6. 2013
    We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP...
  64. doi Genetic polymorphisms in the Fas and FasL genes are associated with epithelial ovarian cancer risk and clinical outcomes
    Yan Li
    Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China
    Gynecol Oncol 128:584-9. 2013
    In this study, we evaluated whether functional polymorphisms within the Fas and FasL genes were associated with the risk of developing epithelial ovarian cancer (EOC) and survival of patients with EOC.
  65. ncbi Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
    T Suda
    Osaka Bioscience Institute, Japan
    Cell 75:1169-78. 1993
    ..Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis...
  66. ncbi Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
    M O Westendorp
    Tumorimmunology Program, German Cancer Research Centre, Heidelberg
    Nature 375:497-500. 1995
    ..We show here that HIV-1 Tat strongly sensitizes TCR- and CD4(gp120)-induced apoptosis by upregulation of CD95 ligand expression...
  67. ncbi Human Fas ligand: gene structure, chromosomal location and species specificity
    T Takahashi
    Osaka Bioscience Institute, Japan
    Int Immunol 6:1567-74. 1994
    Fas ligand (FasL) is a 40 kDa type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, Fas. In this report, we isolated the chromosomal gene for human FasL...
  68. ncbi Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
    M P Boldin
    Department of Membrane Research and Biophysics, The Weizmann Institute of Science, Rehovot, Israel
    Cell 85:803-15. 1996
    ..These findings suggest that MACH is the most upstream enzymatic component in the Fas/APO-1- and p55-R-induced cell death signaling cascades...
  69. ncbi Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape
    M Hahne
    Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Science 274:1363-6. 1996
    ..Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL+ tumor cells...
  70. ncbi Downregulation of Fas ligand by shedding
    M Tanaka
    Department of Genetics, Osaka University Medical School, Suita, Japan
    Nat Med 4:31-6. 1998
    Apoptosis-inducing Fas ligand (FasL) is a type II membrane protein, predominantly expressed in the activated T cells. FasL is cleaved by a putative metalloproteinase to produce a soluble form...
  71. pmc CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway
    S Parlato
    Laboratories of Virology, Istituto Superiore di Sanità Viale Regina Elena 299, 00161 Rome, Italy
    EMBO J 19:5123-34. 2000
    ....
  72. ncbi The biochemistry of apoptosis
    M O Hengartner
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 407:770-6. 2000
    ..Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death...
  73. ncbi Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    N Holler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 1:489-95. 2000
    ..Thus, Fas, TRAIL and TNF receptors can initiate cell death by two alternative pathways, one relying on caspase-8 and the other dependent on the kinase RIP...
  74. ncbi Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail
    E J Blott
    Sir William Dunn School of Pathology, Oxford University, South Parks Rd, Oxford, OX1 3RE, UK
    J Cell Sci 114:2405-16. 2001
    Fas ligand (FasL) induces apoptosis through its cell surface receptor Fas...
  75. ncbi Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians
    M Pinti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Cell Death Differ 9:431-8. 2002
    ..However, little is known about the genetic regulation of Fas and its ligand, FasL. We have studied their polymorphisms in 50 centenarians and 86 young donors living in Northern Italy...
  76. pmc Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    Giovanna Andreola
    Unit of Immunotherapy of Human Tumors, Istituto Nazionale dei Tumori, Milan 20133, Italy
    J Exp Med 195:1303-16. 2002
    The hypothesis that FasL expression by tumor cells may impair the in vivo efficacy of antitumor immune responses, through a mechanism known as 'Fas tumor counterattack,' has been recently questioned, becoming the object of an intense ..
  77. ncbi Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma
    Tong Sun
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Natl Cancer Inst 96:1030-6. 2004
    ..system is a key regulator of apoptotic cell death, and loss of FAS expression and gain of FAS ligand (FASL) expression play important roles in the development and progression of cancer...
  78. pmc Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer
    X Zhang
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Med Genet 42:479-84. 2005
    The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis...
  79. pmc FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer
    Tong Sun
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, China
    J Exp Med 202:967-74. 2005
    ..Xiong, Y. Zhou, and D. Lin. 2005. J. Med. Genet. 42:479-484) that functional polymorphisms in FAS and FAS ligand (FASL) are associated with susceptibility to lung cancer and esophageal cancer; however, the mechanisms underlying this ..
  80. ncbi Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity
    Nathalie Cahuzac
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, 06189 Nice, France
    Blood 107:2384-91. 2006
    Fas ligand (FasL), a member of the TNF protein family, potently induces cell death by activating its matching receptor Fas...
  81. ncbi [Genetic polymorphisms of apoptosis-associated genes FAS and FASL and risk of colorectal cancer]
    Shen Yang
    Department of Gastroenterological Surgery, Peking University People s Hospial, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 85:2132-5. 2005
    The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signaling pathway has been shown to participate in tumorigenesis...
  82. ncbi Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis
    Chunping Li
    Department of Molecular Genetic Toxicology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China
    Pharmacogenet Genomics 16:245-51. 2006
    ..We hypothesized that the FAS -1377G>A, -670A>G, and FASLG -844T>C polymorphisms are associated with risk of bladder cancer...
  83. pmc The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse
    Marcus Lettau
    Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 103:5911-6. 2006
    The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes...
  84. ncbi A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome
    Manuel Del-Rey
    Servicio de Inmunologia, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
    Blood 108:1306-12. 2006
    ..This report describes the first homozygous FASL gene mutation in a woman with clinical and immunologic features of ALPS...
  85. ncbi Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5596-602. 2006
    ....
  86. ncbi Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population
    Sun Ha Park
    Cancer Research Institute, School of Medicine, Kyungpook National University, Dong In 2Ga 101, Daegu 700 422, Republic of Korea
    Lung Cancer 54:303-8. 2006
    The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis...
  87. ncbi Importance of FAS-1377, FAS-670, and FASL-844 polymorphisms in tumor onset, progression, and pigment phenotypes of Swedish patients with melanoma: a case-control analysis
    Hong Zhang
    Division of Dermatology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Cancer J 13:233-7. 2007
    ..The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic signaling pathway and tumor growth ..
  88. ncbi FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer
    Sokbom Kang
    Research Institute and Hospital, National Cancer Center, Madu dong, Ilsandong gu, Goyang, 410 769, South Korea
    Cancer Genet Cytogenet 180:1-5. 2008
    Single-nucleotide polymorphisms of the FAS -1377G/A, FAS -670A/G, and FASL -844T/C genes may alter transcriptional activity of these genes...
  89. pmc Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer
    Monica Ter-Minassian
    Department of Environmental Health, Harvard School of Public Health, Boston 02115, MA, USA
    Carcinogenesis 29:2147-52. 2008
    ..17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC...
  90. pmc Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis
    Laura Strauss
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Immunol 182:1469-80. 2009
    ..Treg from all subjects expressed CD95(+), but only Treg from cancer patients expressed CD95L. These Treg, when activated via TCR plus IL-2, up-regulated CD95 and CD95L expression (p < 0...
  91. doi FASLG polymorphism is associated with cancer risk
    Yan Liu
    Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Eur J Cancer 45:2574-8. 2009
    ..However, more comprehensive understanding of the association would certainly have an immense prospect in the promising field of individualised preventive care...
  92. doi Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure
    Shashideep Singhal
    Division of Gastroenterology, Department of Medicine, Maulana Azad Medical College and Lok Nayak Hospital, University of Delhi, Delhi, India
    Biomarkers 14:347-53. 2009
    ..We investigated the clinical significance of proinflammatory/apoptotic cytokines soluble Fas ligand (sFasL) and tumour necrosis factor (TNF)-alpha in ALF of specific aetiology...
  93. doi Underexpression and overexpression of Fas and Fas ligand: a double-edged sword
    Shahid R Randhawa
    Department of Pediatrics, Section of Allergy and Immunology, LSU Health Sciences Center, Shreveport, Louisiana 71130, USA
    Ann Allergy Asthma Immunol 104:286-92. 2010
    To compare autoimmune lymphoproliferative syndrome (ALPS) and Stevens-Johnson syndrome (SJS) with respect to the defects in Fas- and Fas ligand (FasL)-mediated apoptosis.
  94. doi Polymorphisms of death pathway genes FAS and FASL and risk of nasopharyngeal carcinoma
    Yun Cao
    Department of Pathology, Sun Yat sen University Cancer Center, Guangzhou, PR China
    Mol Carcinog 49:944-50. 2010
    ..Functional polymorphisms in the FAS (FAS -1377G/A) and FASL (FASL -844T/C) genes alter their transcriptional activity...
  95. doi A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer
    Wen Wei Sung
    Institute of Medical and Molecular Toxicology, School of Medicine, Institute of Medicine, and School of Public Health, Chung Shan Medical University, Changhua, Taiwan, ROC
    Clin Cancer Res 17:5991-9. 2011
    Fas ligand (FasL) -844T/C polymorphism (rs763110) has a demonstrated association with lung cancer risk. FasL -844CC with higher FasL expression has been suggested to contribute to tumor progression via immune escape...
  96. doi Functional polymorphisms in FAS/FASL system contribute to the risk of occurrence but not progression of gastric cardiac adenocarcinoma
    Weimin Zhang
    Zhejiang University School of Medicine, Hangzhou, China
    Hepatogastroenterology 59:141-6. 2012
    Loss of FAS and gain of aberrant FASL expression are common features of malignant transformation...
  97. doi Functional polymorphisms in FAS, FASL and CASP8 genes and risk of childhood acute lymphoblastic leukemia: a case-control study
    Na Tong
    Department of Molecular and Genetic Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
    Leuk Lymphoma 53:1360-6. 2012
    Genetic polymorphisms in the promoter regions of FAS, FASL and CASP8 involved in the apoptotic signaling pathway are thought to be associated with susceptibility to cancer...
  98. doi FASL-844 T/C polymorphism: a biomarker of good prognosis of breast cancer in the Tunisian population
    Wijden Mahfoudh
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Hum Immunol 73:932-8. 2012
    The single nucleotide polymorphism, rs763110 (-844 T/C) of the FASL gene, is located within a putative binding motif of CAAT/enhancer-binding protein β transcription factor...
  99. ncbi Altered expression of survivin, Fas and FasL contributed to cervical cancer development and metastasis
    S F Wu
    Department of Obstetrics and Gynecology, Shanghai Jiaotong University, Shanghai, China
    Eur Rev Med Pharmacol Sci 16:2044-50. 2012
    ..To evaluate the expression of apoptosis-related genes and their correlation with prognosis in cervical cancer patients...
  100. doi Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population
    Jiwen Wang
    Department of Thoracic Surgery, Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou 310022, China
    Gene 524:193-6. 2013
    Accumulating evidences indicate that the functional FAS-1377G>A, -670A>G and FASL-844T>C polymorphisms affect the risk of several kinds of cancers...
  101. ncbi Differential susceptibility to HIV-GP120-sensitized apoptosis in CD4+ T-cell clones with different T-helper phenotypes: role of CD95/CD95L interactions
    P Accornero
    Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italy
    Blood 89:558-69. 1997
    ..Apoptosis induced by gp120 in the Th1 clones is inhibited by either an anti-CD95 neutralizing MoAb or an anti-CD95L neutralizing MoAb as well as by a specific interleukin-1 beta converting enzyme (ICE) inhibitor...

Research Grants70

  1. ANTIGEN IMMUNOSUPPRESSION BY KILLER LANGERHANS CELLS
    Akira Takashima; Fiscal Year: 2004
    ..We hypothesized that LC genetically modified to over-express CD95L (Fas ligand) termed "killer" LC, would deliver apoptotic signals to T cells upon antigen-specific interaction...
  2. Eosinophil-Airway Epithelial Fas-FasL Interactions
    Kimm Hamann; Fiscal Year: 2004
    Studies are proposed to examine the functional expression of Fas ligand (FasL) by airway epithelial cells and the induction of cell death in human eosinophils by this FasL...
  3. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ..Activated allogeneic T lymphocytes express Fas-ligand (CD178), which crosslinks Fas receptor (CD95), prominently expressed on hepatocytes, thereby inducing hepatic injury...
  4. Role of Stress-Response Protein gp96 in the Persistence of Rheumatoid Arthritis
    Richard M Pope; Fiscal Year: 2012
    ..We identified a novel mechanism whereby Fas-FasL interactions on macrophages (M&s), while not inducing apoptosis, enhanced activation through the TLR4 pathway...
  5. Protection of vaccine immunity by inhibiting Fas/FasL signaling
    Maria S Salvato; Fiscal Year: 2010
    Lymphocytes bearing high levels of FasL are known to suppress cell-mediated immunity and destroy the efficacy of DNA vaccines...
  6. DYSREGULATION OF APOPTOSIS IN LGL LEUKEMIA
    Thomas Loughran; Fiscal Year: 2000
    ..Results of these studies may suggest that novel strategies targeting Fas ligand would be efficacious for treatment of malignancies and autoimmune diseases. ..
  7. Fas Internalization and Beta Cells
    Marcus Peter; Fiscal Year: 2003
    ..Among other factors, the Fas ligand (FasL) as been shown to contribute to the destruction of islets...
  8. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  9. Fatal Attration: T lymphocytes and liver endothelial cell during sepsis.
    NOELLE A HUTCHINS; Fiscal Year: 2012
    ..We have previously reported that CD8+ T cells in response to sepsis upregulate FasL (ligand) in the liver...
  10. Mechanisms of CD8+ T Cell Apoptosis During Acute and Chronic Viral Infections
    JASON MITCHELL GRAYSON; Fiscal Year: 2010
    ..abstract_text> ..
  11. Novel Fas/CD95 Signaling Mechanisms
    Marcus E Peter; Fiscal Year: 2011
    The death receptor Fas (CD95/APO-1) mediates apoptosis in many tissues. Upon stimulation by its ligand FasL, it forms a death inducing signaling complex (DISC) consisting of the adaptor molecule FADD, the initiator caspases 8 and 10, and ..
  12. Imaging and Function of the Immunological Synapse
    David C Parker; Fiscal Year: 2012
    ..the role of the immunological synapse in the delivery of effector functions from CD4 T cells to APC, using FasL (CD178) and CD40L (CD154) as prototypes of membrane-bound effector cytokines...
  13. INTERPLAYS BETWEEN THE JAW MESENCHYMAL STEM CELLS AND T LYMPHOCYTES
    Yufang Shi; Fiscal Year: 2010
    ..our preliminary studies revealed that activated T cells are capable of inducing BMMSC apoptosis through the Fas/FasL pathway, suggesting a novel crosstalk mechanism between T cells and BMMSCs...
  14. REGULATION OF HIV-MEDIATED CD4 T CELL APOPTOSIS
    Andrew D Badley; Fiscal Year: 2012
    ..mechanisms contribute to CD4 T cell loss during HIV disease, including enhanced production of proapoptotic ligands (FasL and TRAIL) by HIV infected macrophages and dendritic cells, microbial translocation across the gut epithelia, and ..
  15. Heat Shock Factor-1 and Death Ligand Expression
    HELEN BEERE; Fiscal Year: 2009
    ..We will determine (a) if HSF-1 regulates the induction and consequences of FasL expression in vivo...
  16. John H Richburg; Fiscal Year: 2016
    ..We have previously revealed the participation of FasL and Fas, two members of the tumor necrosis factor (TNF) superfamily of proteins, in triggering apoptosis of ..
  17. Mechanisms of Fas Ligand Control of Insulitis Initiation in Autoimmune Diabetes
    ABDEL HAMAD; Fiscal Year: 2012
    ..proposal investigates mechanisms that powerfully control ss-cell specific autoreactive T-cells when Fas ligand (FasL), an apoptosis-inducing member of tumor necrosis factor (TNF) family, is genetically or pharmacologically ..
  18. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2009
    ..We believe that FasL, whose expression increases during viral infection, is a principal mediator of lymphocyte depletion, especially ..
  19. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..in controlling new vessel growth in the eye by examining the function of two molecules, Fas (CD95) and FasL (CD95L)...
  20. Fas/FasL System In Normal Mammary Gland Development
    Gil Mor; Fiscal Year: 2003
    ..Thus, alterations in the Fas/FasL system may regulate the survival of proliferating cells that have the potential for malignant transformation...
  21. ROLE OF THE FAS ANTIGEN IN OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2004
    ..Fas is a cell surface receptor that induces apoptosis in sensitive cells when bound by Fas ligand (FasL)...
  22. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..apoptosis is associated with development of drug resistance in CML, but does not correlate with decreased Fas/FasL. Increased [unreadable]catenin activity in CML- CSC/LSC precedes progression to blast crisis (BC), but does not ..
  23. Redox regulation of intestinal T cells
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..We can then target this molecule for 'correction'and in the future determine whether this type of treatment is an effective therapy for mucosal infections, vaccine development, or mucosal autoimmune-like diseases. ..
  24. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2011
    ..burgdorferi lipopeptides (that bind Toll-like Receptor 2, TLR2), express high levels of Fas-Ligand (FasL), may react to CD1b, and resemble chronically activated T cells...
  25. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..associated with development of drug resistance in CML, but does not correlate with decreased expression of Fas or FasL. Increased ?catenin activity precedes blast crisis (BC) in CML, but does not correlate with Wnt expression or ..
  26. IMMUNITY AND VIRUS DISEASE
    Raymond M Welsh; Fiscal Year: 2013
    ..The activated CD8 T cells during the acute response also become sensitized to undergo Fas/FasL-mediated activation-induced cell death (AICD) on strong signaling through their TCR, and this may contribute to the ..
  27. Prakash S Nagarkatti; Fiscal Year: 2014
    ..Thus, our studies are aimed at providing insights into the mechanism by which estrogens mediate their toxic effects on the immune system, thereby leading to the development of strategies for their prevention and treatment. ..
  28. Molecular Basis of the Anti-inflammatory Action of MAYP/PSTPIP2
    Violeta Chitu; Fiscal Year: 2012
    ..In addition, they will provide a better understanding of the action of PCH proteins in controlling the inflammatory response. ..
  29. Immunological Mechanisms in Systemic Autoimmune Disease
    Ann Marshak-Rothstein; Fiscal Year: 2012
    ..T cells obtained from wildtype, lpr, or gld DO11 mice, will be included in the analysis since over-expression of FasL has been found to trigger a chronic fibrotic response in numerous experimental settings...
  30. Chandrashekhar R Gandhi; Fiscal Year: 2016
    ..LPS also increases expression of FasL on HSCs, which causes death of adjacent hepatocytes by interacting with Fas...
  31. T Cell Modulation by NKG2D
    Thomas Spies; Fiscal Year: 2013
    ..Conversely, enhancing this mechanism in autoimmune disease patients may lower disease activity. The results of our studies may thus lead to development of new therapies. ..
  32. Programmed Cell Death: Role in Septic Immune Dysfunction
    Alfred Ayala; Fiscal Year: 2013
    ..However, the nature of Fas/ FasL interactions at a cell-cell as well as an intracellular level in these various tissue sites that lead from ..
  33. Trever G Bivona; Fiscal Year: 2016
    ..We will use transgenic murine models of EGFR-mutant lung cancer in conjunction with transgenic murine models of CD95 ligand that allow for selective activation of CD95 pro-survival output via NF-kB...
  34. Immunosuppressive pathways in acute HIV infection
    Nina Bhardwaj; Fiscal Year: 2010
    ..such as the up-regulation of death pathway molecules such as TRAIL and its ligand DR5, as well as Fas ligand (FasL). Elevation of these factors has been described in both the eclipse and early viral ramp up phases...
  35. NK Cell Control of Acute Influenza Virus Infection
    Jonathan W Heusel; Fiscal Year: 2010
    ..Finally, the findings will impact the design of new vaccination strategies in order to exploit the contributions from natural killer cells. ..
  36. Fas pathway in organ-specific tolerance and autoimmunity
    ABDEL HAMAD; Fiscal Year: 2010
    ..Engagement of Fas by its ligand (FasL) transduces caspase signaling cascade that leads to nuclear fragmentation, cytoplasmic condensation and cell death...
  37. Maha Abdellatif; Fiscal Year: 2014
    ..regulates phosphatase and tensin homologue deleted on chromosome 10 (PTEN), but also directly targets Fas Ligand (FasL)...
  38. Antioxidant Systems and Age-related Macular Degeneration
    Paul Sternberg; Fiscal Year: 2010
    ....
  39. Mechanisms of Chemo/Radioresistance in Human Gliomas
    Eliot M Rosen; Fiscal Year: 2012
    ..Death receptor agonists (TRAIL, FASL) are promising anti-tumor agents by virtue of their ability to selectively kill tumor cells...
  40. The role of common genetic variation in the Fas pathway in acute lung injury
    BRADFORD JOSEPH GLAVAN; Fiscal Year: 2010
    ..In particular, the Fas/FasL pathway, known to be an important modulator of the immune response, has been implicated in the inflammation and ..
  41. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  42. A role for IL-1 in SJIA monocyte phenotypes: A RAPPORT ancillary study
    Elizabeth D Mellins; Fiscal Year: 2013
    ..stimuli, both intrinsic and extrinsic, likely due at least in part to reduced levels of Bid cleavage and surface FasL, respectively...
  43. Yvonne M W Janssen-Heininger; Fiscal Year: 2016
    ..S-glutathionylation of Fas promotes its recruitment into lipid rafts, and enhances binding of FasL, caspase activation and apoptosis, providing a feed forward amplification loop to enhance the strength of the ..
  44. Calmodulin Regulates Fas-Mediated Apoptosis: A Target for Cancer Therapy
    Jay M McDonald; Fiscal Year: 2013
    ..All of these diseases are very important health problems for the Veteran's population. ..
  45. Regulation of vascular leakage in age related macular degeneration
    MEREDITH GREGORY-KSANDER; Fiscal Year: 2013
    ..b>FasL is an important protein in maintaining immune privilege in the eye, where it is thought to induce apoptosis of ..
  46. SATDARSHAN SINGH MONGA; Fiscal Year: 2016
    ..The molecular basis of these findings will be elucidated. Thus, this proposal will be a comprehensive analysis of canonical &noncanonical Wnt signaling in hepatic biology. ..
  47. ApoFasL as a novel treatment for Type 1 Diabetes in Nonhuman Primates
    Haval Shirwan; Fiscal Year: 2011
    ..ProtEx(tm) technology in a rapid, practical, and nontoxic manner to efficiently display a novel form of Fas ligand (FasL) on the islet surface...
  48. Elucidating the Fas-activated inflammation-signaling complex (FISC)
    Mihail Iordanov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Engagement of the receptor protein Fas/TNFRSF6 by its ligand, FasL/TNFSF6, triggers apoptotic cells death via well-understood mechanisms involving the assembly of a death-inducing signaling complex (..
  49. Modulation of tumor susceptibility to NK cells induced by JAK family genes
    Roberto Bellucci; Fiscal Year: 2012
    ..analysis showed that target cells knock down for Jak1 significantly modulated the expression of genes in the TRAIL/FASL pathway. These pathways are known to induce target apoptosis after NK cells engagement...
  50. Effect of Resveratrol on Staphylococcal Enterotoxin B induced Vascular Leak
    SADIYE AMCAOGLU RIEDER; Fiscal Year: 2010
    ..of vascular leak induced by SEB and the role of RES as a treatment method, (2) investigate the role of Fas-FasL interactions in RES- induced apoptosis of T, NK T and dendritic (DC) cells, and (3) test the roles of Aryl ..
  51. Vaccine-Dac/Bev Combinatorial Therapy in Ovarian Cancer
    George Coukos; Fiscal Year: 2012
    ..tumors (through down-regulation of cell adhesion molecules), or killing extravasating T cells in tumors (through FasL-mediated apoptosis);b) Treg cells located in the tumor microenvironment suppress the function of effector T cells...
  52. Shukti Chakravarti; Fiscal Year: 2016
    ..Thus, innate immune response is impaired in our Lum-/- mice. Lumican also binds FasL and TGFbeta, and in the Lum-/- mice these pathways are disrupted...
  53. CTL EFFECTOR MECHANISMS IN ADENOVIRAL HEPATITIS
    DWAIN LOUIS THIELE; Fiscal Year: 2010
    ..hepatocytes from the liver is mediated predominately by alternative CTL effector mechanisms that utilize Fas/FasL, TNF/TNFR1 and/or other death receptor mediated pathways...
  54. THE ROLE OF APOPTOTIC MOLECULES IN HERPETIC STROMAL
    Patrick M Stuart; Fiscal Year: 2010
    ..molecules have during herpetic stromal keratitis we propose: To determine the specific contributions of Fas and FasL to ocular disease, protection from neuropathology, growth of virus, and maintenance of viral latency...
  55. Yang Jin; Fiscal Year: 2015
    ..Cav-1 and flot1 together regulate hyperoxia induced cell death via Fas pathways independent of FasL. Flot1 and cav-1 both interacted with Fas after hyperoxia, indicating that cav-1 and flot1 cross talk and mediate ..
  56. Regulation of Fas-Mediated Lung Cell Apoptosis
    Yon Rojanasakul; Fiscal Year: 2009
    ..that while Fas can trigger apoptosis of lung cells, the expression level of Fas and its activation by Fas ligand (FasL) do not correlate with the susceptibility toFas- mediated cell death, indicating that regulators of the apoptosis-..
  57. Prakash S Nagarkatti; Fiscal Year: 2016
    ..Our Preliminary Studies have demonstrated that RES induces apoptosis primarily in activated T cells through Fas-FasL interactions, involving aryl hydrocarbon receptor (AhR) and estrogen receptor (ER)...
  58. Molecular mechanism of a cellular necrotic cell death pathway
    Junying Yuan; Fiscal Year: 2010
    ..Interestingly, stimulation of certain apoptotic deficient cells with death receptor ligands such as FasL or TNF has been shown to lead to necrotic cell death termed necroptosis...
  59. MECHANISMS OF LIVER CELL INJURY
    Gregory Gores; Fiscal Year: 2009
    ..The significance of the information generated is that it will help provide a framework for the potential development of novel therapeutic strategies effective in attenuating cholestatic liver injury. ..
  60. ABDEL HAMAD; Fiscal Year: 2016
    ..proposal investigates mechanisms that powerfully control ss-cell specific autoreactive T cells when Fas ligand (FasL), an apoptosis-inducing member of TNF family, is genetically or pharmacologically inactivated...
  61. Ah Receptor Action and Apoptosis
    CORNELIS JOHAN ELFERINK; Fiscal Year: 2010
    ..hypothesis, supported by the preliminary evidence, suggests that AhR activity sensitizes liver cells to Fas ligand (FasL) induced apoptosis, possibly by regulating expression of proteins that promote the cell death program...
  62. Ravi V Bellamkonda; Fiscal Year: 2016
    ..Successful completion of the proposed studies would have significant impact on improvement of the quality of life of individuals with TBI, and have implications for stem cell therapies in other organ systems. ..
  63. Marcus E Peter; Fiscal Year: 2014
    ..Furthermore, cancer patients frequently have elevated levels of the physiological ligand for Fas, FasL. These data raised the intriguing possibility that Fas might actually promote the growth of tumors through its ..
  64. STEPHANIE RENAE JACKSON; Fiscal Year: 2015
    ..for CD8+ T cell trafficking or control of infected or malignant cells, includin CXCR3, granzyme B, perforin, and FasL. Our data suggest that T-bet and Eomes may be fundamental to the decision of T cell immunity versus tolerance, and ..
  65. IL-4 Overexpressing Dendritic Cells and Exosomes for Treatment of Type 1 Diabetes
    MELANIE A RUFFNER; Fiscal Year: 2010
    ..I have tested DC infected with adenoviral vectors expressing several different transgenes, including FasL, IDO, IL-10, as well as a soluble and membrane-bound form of IL-4 (slL-4 and mblL-4), for their ability to delay ..
  66. ALLOGENEIC MIHA INDUCED MARROW ALLOGRAFT RESISTANCE
    ROBERT BENJAMIN LEVY; Fiscal Year: 2010
    ..resistance pathway in recipients sensitized to donor antigens mediated by host CD8 T cells independent of perforin, fasl, TNF and other death receptor ligands...
  67. MEREDITH GREGORY-KSANDER; Fiscal Year: 2015
    ..Fas Ligand (FasL) is a pro-apoptotic protein that is constitutively expressed in the retina where it is thought to protect tissue ..
  68. Marcus E Peter; Fiscal Year: 2014
    ..The results could pave the way to better diagnostic tools (detection of LOGs in human cancers) and to improved cancer therapy (reintroducing let-7 and miR-200) into tumor cells. ..
  69. ApoFasL: a Novel Immunotherapeutic for T1D
    Rolf Huseby; Fiscal Year: 2007
    ..islets as a therapeutic intervention for the treatment of Type 1 diabetes Given the important role played by Fas/FasL system in immune tolerance to self antigens, immune privilege, and lymphocyte homeostasis, and the extensive use of ..
  70. Engineering Bone Marrow Cells for Immunotherapy
    Esma Yolcu; Fiscal Year: 2006
    ..to use a novel and practical approach to engineer bone marrow cells to display on their surface a modified form of FasL protein with potent apoptotic activity as an immunomodulatory agent and test the capacity of the engineered cells ..