Fas

Summary

Gene Symbol: Fas
Description: Fas cell surface death receptor
Alias: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, tumor necrosis factor receptor superfamily member 6, APO-1 cell surface antigen, CD95 antigen, FASLG receptor, Fas (TNF receptor superfamily, member 6), Fas AMA, TNF receptor superfamily member 6, apoptosis antigen 1, apoptosis signaling receptor FAS, apoptosis-mediating surface antigen FAS, mutant tumor necrosis receptor superfamily member 6, tumor necrosis factor receptor superfamily, member 6
Species: human

Top Publications

  1. ncbi Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing
    I Cascino
    Department of Immunobiology, Institute of Cell Biology, National Research Council, Rome, Italy
    J Immunol 154:2706-13. 1995
  2. ncbi Defective apoptosis due to a point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease
    A M Peters
    University Children s Hospital Freiburg, Germany
    Exp Hematol 27:868-74. 1999
  3. doi Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses
    Frank Kirchhoff
    Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany
    Cell Host Microbe 8:55-67. 2010
  4. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  5. pmc Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    X Yang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:1067-76. 1997
  6. ncbi Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    H Zou
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 90:405-13. 1997
  7. pmc Functional polymorphisms of FAS and FASL gene and risk of breast cancer - pilot study of 134 cases
    Mohammad Hashemi
    Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
    PLoS ONE 8:e53075. 2013
  8. doi Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
    L A Pradelli
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, équipe 3 AVENIR, Nice, France
    Oncogene 29:1641-52. 2010
  9. doi Are cell cycle and apoptosis genes associated with prostate cancer risk in North Indian population?
    Raju Kumar Mandal
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Uttar Pradesh, India
    Urol Oncol 30:555-61. 2012
  10. doi Functions of Tat: the versatile protein of human immunodeficiency virus type 1
    Bizhan Romani
    Division of Medical Virology, Department of Pathology, University of Stellenbosch, Tygerberg 7505, South Africa
    J Gen Virol 91:1-12. 2010

Research Grants

  1. Fas Internalization and Beta Cells
    Marcus Peter; Fiscal Year: 2003
  2. David N Zacks; Fiscal Year: 2014
  3. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
  4. RIPK1: A new target for traumatic brain injury?
    Michael J Whalen; Fiscal Year: 2013
  5. Role of Stress-Response Protein gp96 in the Persistence of Rheumatoid Arthritis
    Richard M Pope; Fiscal Year: 2012
  6. Protection of vaccine immunity by inhibiting Fas/FasL signaling
    Maria S Salvato; Fiscal Year: 2010
  7. Prevention of photoreceptor cell death with intravitreal Fas-receptor antagonist
    Jeffrey A Jamison; Fiscal Year: 2012
  8. SERGE E PRZEDBORSKI; Fiscal Year: 2016
  9. Qun Lu; Fiscal Year: 2014
  10. Michael J Whalen; Fiscal Year: 2016

Detail Information

Publications360 found, 100 shown here

  1. ncbi Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing
    I Cascino
    Department of Immunobiology, Institute of Cell Biology, National Research Council, Rome, Italy
    J Immunol 154:2706-13. 1995
    b>Fas/Apo-1 molecule is an apoptosis-signaling cell surface Ag belonging to the TNFR family...
  2. ncbi Defective apoptosis due to a point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease
    A M Peters
    University Children s Hospital Freiburg, Germany
    Exp Hematol 27:868-74. 1999
    Apoptosis via CD95 and its ligand is an important mechanism that prevents uncontrolled proliferation of activated lymphocytes and regulates lymphocyte homeostasis...
  3. doi Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses
    Frank Kirchhoff
    Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany
    Cell Host Microbe 8:55-67. 2010
    ....
  4. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  5. pmc Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    X Yang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:1067-76. 1997
    The Fas cell surface receptor induces apoptosis upon receptor oligomerization. We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain...
  6. ncbi Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    H Zou
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 90:405-13. 1997
    ..The COOH-terminal region of Apaf-1 comprises multiple WD repeats, which are proposed to mediate protein-protein interactions. Cytochrome c binds to Apaf-1, an event that may trigger the activation of caspase-3, leading to apoptosis...
  7. pmc Functional polymorphisms of FAS and FASL gene and risk of breast cancer - pilot study of 134 cases
    Mohammad Hashemi
    Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
    PLoS ONE 8:e53075. 2013
    b>Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in the extrinsic apoptotic pathway. De-regulation of this pathway, i.e...
  8. doi Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
    L A Pradelli
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, équipe 3 AVENIR, Nice, France
    Oncogene 29:1641-52. 2010
    ..removal or the use of nonmetabolizable form of glucose (2-deoxyglucose) dramatically enhances apoptosis induced by Fas or by tumor necrosis factor-related apoptosis-inducing ligand...
  9. doi Are cell cycle and apoptosis genes associated with prostate cancer risk in North Indian population?
    Raju Kumar Mandal
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Uttar Pradesh, India
    Urol Oncol 30:555-61. 2012
    ..In the present study, we investigated the diagnostic value of 3 different genes associated with CaP carcinogenesis, encoding for cell cycle (MDM2, CCND1) and apoptotic (Fas) genes that are differentially expressed in CaP.
  10. doi Functions of Tat: the versatile protein of human immunodeficiency virus type 1
    Bizhan Romani
    Division of Medical Virology, Department of Pathology, University of Stellenbosch, Tygerberg 7505, South Africa
    J Gen Virol 91:1-12. 2010
    ..Due to its pivotal role in viral replication and in disease pathogenesis, Tat and the cellular pathways targeted by Tat are potential targets for new anti-HIV drugs...
  11. ncbi FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer
    Sokbom Kang
    Research Institute and Hospital, National Cancer Center, Madu dong, Ilsandong gu, Goyang, 410 769, South Korea
    Cancer Genet Cytogenet 180:1-5. 2008
    Single-nucleotide polymorphisms of the FAS -1377G/A, FAS -670A/G, and FASL -844T/C genes may alter transcriptional activity of these genes...
  12. ncbi Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma
    Tong Sun
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Natl Cancer Inst 96:1030-6. 2004
    The FAS receptor-ligand system is a key regulator of apoptotic cell death, and loss of FAS expression and gain of FAS ligand (FASL) expression play important roles in the development and progression of cancer...
  13. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  14. ncbi Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1
    Kathrin Maedler
    Larry L Hillblom Islet Research Center, University of California, Los Angeles, USA
    Diabetes 55:2455-62. 2006
    ..In rat islets, constitutive expression of Fas ligand and glucose-induced Fas receptor expression were observed only in 7- to 8-month-old but not in 2- to 3-month-..
  15. pmc Functional polymorphisms in FAS/FASL system increase the risk of neuroblastoma in Chinese population
    Wei Han
    Department of Surgical Oncology, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing, China
    PLoS ONE 8:e71656. 2013
    The FAS and FASL system plays a substantial role in apoptosis and immune escape of cells...
  16. ncbi Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis
    Chunping Li
    Department of Molecular Genetic Toxicology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China
    Pharmacogenet Genomics 16:245-51. 2006
    b>FAS and FASLG together initiate apoptosis, which prevents tumor development. FAS and FASLG polymorphisms in the promoter regions can alter the transcriptional activities and thus alter risk of cancer...
  17. ncbi Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population
    Sun Ha Park
    Cancer Research Institute, School of Medicine, Kyungpook National University, Dong In 2Ga 101, Daegu 700 422, Republic of Korea
    Lung Cancer 54:303-8. 2006
    The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis...
  18. ncbi Role of BCL2 (ala43thr), CCND1 (G870A) and FAS (A-670G) polymorphisms in modulating the risk of developing esophageal cancer
    Meenu Jain
    Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India
    Cancer Detect Prev 31:225-32. 2007
    ..A study of BCL2 ala43thr, CCND1 G870A and FAS A-670G gene polymorphisms was undertaken to explore their role in influencing the susceptibility for development of ..
  19. doi Functional variants in cell death pathway genes and risk of pancreatic cancer
    Ming Yang
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Clin Cancer Res 14:3230-6. 2008
    b>Fas-Fas ligand (FasL)-mediated death pathway is important in the life and death of immune cells and, therefore, influences immune surveillance of carcinogenesis...
  20. doi FAS-670A/G polymorphism: A biomarker for the metastasis of nasopharyngeal carcinoma in a Chinese population
    Qingyao Zhu
    Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
    Clin Chim Acta 411:179-83. 2010
    b>FAS-670 A/G single nucleotide polymorphism has been demonstrated to affect the expression of FAS gene by altering the transcriptional activity of FAS gene promoter...
  21. doi Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma
    Rong Miao Zhou
    Department of Molecular Biology, the Fourth Affiliated Hospital of Hebei Medical University, Hebei Province, China
    J Gastroenterol Hepatol 25:555-61. 2010
    The FAS and FASL system play an important role in regulating apoptotic cell death...
  22. doi Association of selected variants in genes involved in cell cycle and apoptosis with bladder cancer risk in North Indian population
    Ruchika Gangwar
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    DNA Cell Biol 29:349-56. 2010
    ..Cell cycle (MDM2 and Cyclin D1) and apoptotic (Fas) genes that are differentially expressed in urinary bladder cancer (UBC) were investigated with the susceptibility ..
  23. doi Functional polymorphisms in cell death pathway genes FAS and FAS ligand and risk of prostate cancer in a Chinese population
    Pengfei Shao
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Prostate 71:1122-30. 2011
    ..We hypothesized that the FAS -1377G>A, -670A>G, and FASL -844T>C polymorphisms are associated with risk of prostate cancer (PCa).
  24. doi CD95-mediated cell signaling in cancer: mutations and post-translational modulations
    Sebastien Tauzin
    université Rennes, France
    Cell Mol Life Sci 69:1261-77. 2012
    ..b>CD95 (also known as Fas), a member of the tumor necrosis factor receptor (TNF-R) superfamily, has been initially cloned ..
  25. ncbi Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm
    Y G Ko
    National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 276:39103-6. 2001
    Although Daxx (death-associated protein) was first reported to mediate the apoptotic signal from Fas to JNK in the cytoplasm, other data suggested that Daxx is mainly located in the nucleus as a transcriptional regulator...
  26. ncbi Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation
    Fumiya Hongo
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine and Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, USA
    Biochem Biophys Res Commun 336:692-701. 2005
    ..prostate cancer (CaP) cell lines (PC-3, CL-1, and DU-145) with the nitric oxide (NO) donor DETA/NONOate upregulated Fas expression and sensitized the CaP cells to the Fas ligand CH-11 agonist monoclonal antibody-induced apoptosis...
  27. pmc Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells
    Hubert Arokium
    Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, David Geffen School of Medicine, 615 Charles E Young Dr South, BSRB 173, Los Angeles, CA 90095, USA
    J Virol 83:11283-97. 2009
    ..However, activation of all caspases by virion-associated Vpr was independent of the Fas death receptor pathway...
  28. doi A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis
    Li Geng
    The Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, No 225, Changhai Road, Shanghai 200438, China
    Biochem Biophys Res Commun 408:494-9. 2011
    Interferon-γ (IFN-γ) is considered essential for the regulation of anti-tumor reactions as it sensitizes Fas-related apoptosis in HT29 cells, but the mechanism is unclear...
  29. ncbi HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
    R Geleziunas
    Gladstone Institute of Virology and Immunology, PO Box 419100, San Francisco, California 94141 9100, USA
    Nature 410:834-8. 2001
    ..The subsequent interaction of FasL with Fas (CD95) displayed on neighbouring cells, including HIV-1-specific cytotoxic T lymphocytes, may lead to bystander cell ..
  30. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
    ..X4 and X4/R5 gp120 also induced the relocalization of cytoplasmic CD95 to the membrane and a 23% increase in CD95-mediated apoptosis. No such effects were observed with R5 gp120...
  31. doi Priming of T cells to Fas-mediated proliferative signals by interleukin-7
    Bence Rethi
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Blood 112:1195-204. 2008
    ..Deleterious mechanisms also associated with lymphopenia, such as increased Fas expression and apoptosis of T cell, however, may result in opposing effects...
  32. ncbi Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5596-602. 2006
    Alteration of the FAS/FAS ligand (FASLG) pathway regulating cell death may lead to cancer development, but the effects of functional promoter polymorphisms of the FAS and FASLG genes on risk of squamous cell carcinoma of the head and ..
  33. ncbi Polymorphisms of death pathway genes FAS and FASL and risk of premalignant gastric lesions
    Ping I Hsu
    Division of Gastroenterology and General Medicine, Department of Medicine, Kaohsiung Veterans General Hospital and National Yang Ming University, Kaohsiung, Taiwan, R O C
    Anticancer Res 28:97-103. 2008
    ..a multistep process that begins with the abrogation of normal controls of apoptosis and cell proliferation, and the FAS receptor-ligand system is a key regulator of apoptosis...
  34. doi Cell-specific regulation of Fas exon 6 splicing mediated by Hu antigen R
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Lab 107, C Nicolás Cabrera, 1, Cantoblanco, 28049 Madrid, Spain
    Biochem Biophys Res Commun 402:324-8. 2010
    ..intracellular antigens (TIA) and Hu antigen R (HuR) are concomitant with a splicing switch in apoptosis receptor Fas in HCT-116 cells. Thus, overexpression and knockdown of HuR led to Fas exon 6 skipping and inclusion, respectively...
  35. ncbi CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells
    Adriana Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 34:1930-40. 2004
    We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and activate caspase-8...
  36. ncbi HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)
    Andreas Krueger
    Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Blood 107:3933-9. 2006
    ..In this study we investigated the molecular mechanisms by which HTLV-1 Tax confers resistance toward CD95-mediated apoptosis...
  37. ncbi Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF
    Sergio Huerta
    Department of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    J Surg Res 142:184-94. 2007
    ..In the present report, we investigated the apoptotic gene products that might account for colon cancer evasion of immune attack and chemoradioresistance-induced apoptosis...
  38. doi Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis
    Nizar Chetoui
    Centre de Recherche en Rhumatologie et Immunologie, CHUQ Pavillon CHUL, Ste Foy, Quebec, Canada
    Mol Cancer Res 6:42-52. 2008
    Resistance of malignant melanoma cells to Fas-mediated apoptosis is among the mechanisms by which they escape immune surveillance...
  39. pmc Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    F C Kischkel
    Tumor Immunology Program, German Cancer Center, Heidelberg, Germany
    EMBO J 14:5579-88. 1995
    APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization...
  40. ncbi Fas gene promoter -670 polymorphism in gynecological cancer
    M Ueda
    Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki Osaka, Japan
    Int J Gynecol Cancer 16:179-82. 2006
    Single-nucleotide polymorphism at -670 of Fas gene promoter (A/G) was examined in a total of 354 blood samples from normal healthy women and gynecological cancer patients...
  41. ncbi Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Pharmacogenet Genomics 16:253-63. 2006
    The FAS/FAS ligand (FASLG) system has a key role in regulating cell growth and thus tumorigenesis...
  42. ncbi Importance of FAS-1377, FAS-670, and FASL-844 polymorphisms in tumor onset, progression, and pigment phenotypes of Swedish patients with melanoma: a case-control analysis
    Hong Zhang
    Division of Dermatology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Cancer J 13:233-7. 2007
    ..The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic ..
  43. doi Polymorphisms in the apoptosis-associated genes FAS and FASL and risk of oral cancer and malignant potential of oral premalignant lesions in a Taiwanese population
    Li Hsuan Wang
    Division of Molecular Diagnosis, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Oral Pathol Med 39:155-61. 2010
    Our aim was to measure the relationship of FAS (-1377G>A and -670A>G), FASL (-844C>T) gene variants and risk of oral cancer.
  44. doi Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population
    Jiwen Wang
    Department of Thoracic Surgery, Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou 310022, China
    Gene 524:193-6. 2013
    Accumulating evidences indicate that the functional FAS-1377G>A, -670A>G and FASL-844T>C polymorphisms affect the risk of several kinds of cancers...
  45. doi Relationship between aberrant methylation of FAS promoter and biological behavior of bladder urothelial carcinoma
    Wei Li
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 31:794-8. 2011
    This study examined the promoter methylation of APO-1/CD95 (Fas) gene in bladder urothelial carcinoma and analyzed the relationship between the Fas promoter methylation and the biological behavior of bladder cancer...
  46. ncbi Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele
    Joachim Roesler
    Department of Pediatrics, University Clinic Carl Gustav Carus, Fetscherstr 74, 01307 Dresden, Germany
    Blood 106:1652-9. 2005
    Autoimmune lymphoproliferative syndrome type Ia (ALPS Ia) is caused by mutations in the CD95/APO1/FAS (TN-FRSF6) gene, which lead to a defective CD95 ligand (CD95L)-induced apoptosis...
  47. doi Expression of Fas and Fas ligand in primary cutaneous squamous cell carcinoma in association with grade of tumor differentiation
    Young Bok Lee
    Department of Dermatology, College of Medicine, Catholic University of Korea, Seoul, South Korea
    Int J Dermatol 52:1092-7. 2013
    The aim of this study was to evaluate whether Fas (CD95) and Fas ligand (FasL) immunoreactivity in cutaneous squamous cell carcinoma (SCC) are correlated with grade of tumor differentiation.
  48. ncbi Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
    M O Westendorp
    Tumorimmunology Program, German Cancer Research Centre, Heidelberg
    Nature 375:497-500. 1995
    ..T-cell-receptor (TCR)-induced apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor...
  49. ncbi FAP-1: a protein tyrosine phosphatase that associates with Fas
    T Sato
    La Jolla Cancer Research Foundation, Oncogene and Tumor Suppressor Gene Program, CA 92037, USA
    Science 268:411-5. 1995
    b>Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis...
  50. ncbi Altered expression of FAS system is related to adverse clinical outcome in stage I-II breast cancer patients treated with adjuvant anthracycline-based chemotherapy
    Claudio Botti
    Regina Elena Cancer Institute, Rome, Italy, and University of Camerino, Camerino, Italy
    Clin Cancer Res 10:1360-5. 2004
    To determine the prognostic value of Fas receptor and Fas ligand (FasL) as apoptosis-related biomarkers in the context of chemoresponsiveness in breast cancer (BC) patients submitted to anthracycline-based adjuvant therapy.
  51. pmc Prognostic impact of FAS/CD95/APO-1 in urothelial cancers: decreased expression of Fas is associated with disease progression
    K Yamana
    Division of Molecular Oncology, Department of Signal Transduction Research, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Br J Cancer 93:544-51. 2005
    The death receptor Fas (Apo1/CD95) and Fas ligand (FasL) system is recognised as a major pathway for the induction of apoptosis in vivo, and antiapoptosis via its blockade plays a critical role in carcinogenesis and progression in several ..
  52. pmc miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1
    Robert Schickel
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Mol Cell 38:908-15. 2010
    ..Cells that have undergone an EMT are known to have an increased resistance to apoptosis. CD95/Fas is an apoptosis-inducing receptor expressed on many tissues and tumor cells...
  53. ncbi FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    A M Chinnaiyan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    Cell 81:505-12. 1995
    Using the cytoplasmic domain of Fas in the yeast two-hybrid system, we have identified a novel interacting protein, FADD, which binds Fas and Fas-FD5, a mutant of Fas possessing enhanced killing activity, but not the functionally ..
  54. ncbi Frequent downregulation of Fas (CD95) expression and function in melanoma
    R R Bullani
    Department of Dermatology, Geneva University Medical School, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Melanoma Res 12:263-70. 2002
    Membrane-bound Fas ligand (FasL, Apo-1L, CD95L) induces rapid apoptosis of Fas (CD95)-sensitive cells on interaction with Fas, and is an important effector molecule of cytolytic T lymphocytes (CTLs)...
  55. doi Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus: relation to the organ damage and lymphocytes apoptosis
    Lian Hong Li
    Department of Epidemiology, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, China
    Mol Biol Rep 36:2047-52. 2009
    ..This study is to evaluate the expression of Fas antigen on peripheral blood lymphocytes (PBLs) in SLE, to determine whether membrane Fas (mFas) has a role in the ..
  56. doi Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement
    Nicole Y Tan
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Circ Res 105:422-30. 2009
    b>Fas ligand (FasL)-mediated smooth muscle cell (SMC) apoptosis within the vulnerable plaque may lead to plaque instability and rupture, events that underlie myocardial infarction and stroke.
  57. doi Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus
    Diego Esposito
    Division of Molecular Structure, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Structure 18:1378-90. 2010
    We have addressed complex formation between the death domain (DD) of the death receptor CD95 (Fas/APO-1) with the DD of immediate adaptor protein FADD using nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and size-..
  58. doi A Fas gene polymorphism influences herpes simplex virus type 2 infection in South African women
    Koushik Chatterjee
    Division of Medical Virology, Department of Clinical Laboratory Sciences and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Med Virol 82:2082-6. 2010
    ..Apoptosis can be regulated and triggered by the interaction between Fas and Fas Ligand (FasL)...
  59. doi Associations between the FAS -670 A/G and -1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1, Anam Dong 5 Ga, Seongbuk gu, Seoul, 136 705, Korea
    Mol Biol Rep 39:10671-9. 2012
    The aim of this study was to explore whether FAS -670 A/G and -1,377 G/A polymorphisms confer susceptibility to autoimmune rheumatic diseases...
  60. ncbi Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells
    Toshio Imanishi
    Division of Cardiology, Department of Medicine, Wakayama Medical University, Japan
    Circ J 66:1060-4. 2002
    Under normal conditions, vascular endothelial cells are resistant to Fas-mediated apoptosis, although they express detectable Fas on their cell surface...
  61. ncbi Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation
    Hirotaka Tashiro
    Second Department of Surgery, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, 734 8551 Hiroshima, Japan
    Transpl Int 17:626-33. 2004
    ..There were no changes in the levels of Fas/Fas ligand expression in liver tissues from either the donors or recipients...
  62. ncbi Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Still's disease
    Der Yuan Chen
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    Clin Rheumatol 26:393-400. 2007
    To investigate serum levels of soluble Fas (sFas), soluble Fas ligand (sFas-L), and matrix metalloproteinase-3 (MMP-3) in patients with active untreated adult onset Still's disease (AOSD)...
  63. ncbi A functional Fas promoter polymorphism is associated with a severe phenotype in type 1 autoimmune hepatitis characterized by early development of cirrhosis
    K Agarwal
    Centre for Liver Research, School of Clinical Medical Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Tissue Antigens 69:227-35. 2007
    ..An adenosine to guanine single nucleotide polymorphism in the Fas gene (TNFRSF6) promoter was assessed in 149 well-characterized Caucasoid patients and 172 matched controls...
  64. ncbi Association of Fas-670 gene polymorphism with risk of cervical cancer in North Indian population
    D M Kordi Tamandani
    Department of Biotechnology, Panjab University, Chandigrah, India
    Clin Exp Obstet Gynecol 35:183-6. 2008
    ..The Fas gene plays a key role in regulation of apoptotic cell death and corruption of this signaling pathway has been shown ..
  65. pmc Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes
    Monika A Niewczas
    Research Division of Joslin Diabetes Center, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 4:62-70. 2009
    The aim of our study was to examine serum markers of the TNF and Fas pathways for association with cystatin-C based estimated glomerular filtration rate (cC-GFR) in subjects with type 1 diabetes (T1DM) and no proteinuria.
  66. pmc Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals
    Stacey A Rizza
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    AIDS 24:2639-44. 2010
    ..There are currently no biomarkers that predict treatment response in these coinfected patients...
  67. doi Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-κB in THP-1 cells
    Sang Min Lee
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Cell Immunol 271:157-62. 2011
    Although Fas is known to be an apoptosis triggering molecule, accumulating studies indicate that Fas has non-apoptotic functions in certain cases...
  68. doi Overexpression of gastrokine 1 in gastric cancer cells induces Fas-mediated apoptosis
    Emilia Rippa
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples, Italy
    J Cell Physiol 226:2571-8. 2011
    ..RT-PCR that the overexpression of GKN1 in gastric cancer cell lines (AGS and MKN28) stimulated the expression of Fas receptor...
  69. pmc Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians
    Juozas Kupcinskas
    Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania
    BMC Med Genet 12:112. 2011
    ..between the presence of gastric cancer (GC) and high risk atrophic gastritis (HRAG) and polymorphisms of genes encoding Angiotensin converting enzyme (ACE), Nod-like receptor 1 (NOD1), Toll-like receptor 4 (TLR4) and FAS/FASL.
  70. doi Fas, Fas Ligand, and vitamin D Receptor FokI gene polymorphisms in patients with type 1 diabetes mellitus in the Aegean region of Turkey
    Serap Baydur Sahin
    Department of Endocrinology and Metabolism Disease, Ege University Medical School, Bornova, Izmir, Turkey
    Genet Test Mol Biomarkers 16:1179-83. 2012
    ..To identify additional genetic markers, we aimed to evaluate the relationship between the Fas, Fas ligand (FasL), and vitamin D receptor (VDR) FokI gene polymorphisms and the susceptibility to type 1 diabetes ..
  71. ncbi F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis
    S L Chan
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 274:32461-8. 1999
    ..repeat-containing protein, termed F1Aalpha, in a yeast two-hybrid screen using the cytoplasmic domain of Fas (CD95/APO-1) as bait...
  72. doi Correlation between serum concentrations of soluble Fas (CD95/Apo-1) and IL-18 in patients with systemic lupus erythematosus
    Maryam Sahebari
    Rheumatic Diseases Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Rheumatol Int 32:601-6. 2012
    ..There are cumulative data on the pro-apoptotic role of IL-18, in the Fas-mediated apoptosis. Soluble Fas (Apo/1-CD95) is a marker of apoptosis that appears to increase in serum of SLE patients...
  73. doi Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis
    Giulio Preta
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 586:747-52. 2012
    ..Here we show that cleavage of Scythe by caspase-3 occurs after activation of both the extrinsic (i.e. Fas/APO-1-mediated) and the intrinsic (i.e. staurosporine-induced) apoptosis pathway...
  74. ncbi Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis
    I Cascino
    Department of Immunobiology, National Research Council, Rome, Italy
    J Immunol 156:13-7. 1996
    FAS/Apo-1 (CD95) is an apoptosis-signaling cell surface receptor belonging to the TNF receptor family...
  75. pmc Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
    D A Martin
    Laboratory of Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:4552-7. 1999
    Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur in most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere with apoptosis by an unknown mechanism...
  76. ncbi Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar
    S H Lee
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul
    J Invest Dermatol 114:122-6. 2000
    Fas (Apo-1/CD95) is a cell-surface receptor involved in cell death signaling, and recent reports have suggested that defects within the Fas receptor pathway such as Fas mutation play an important part in the development and progression of ..
  77. ncbi T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 30:661-70. 2000
    b>CD95(APO-1 / Fas) ligand (CD95L) gene expression is critically involved in activation-induced T cell apoptosis...
  78. ncbi Negative regulation of Fas-mediated apoptosis by FAP-1 in human cancer cells
    Y Li
    Department of Otolaryngology Head and Neck Surgery, Columbia University, New York, New York, USA
    Int J Cancer 87:473-9. 2000
    FAP-1 (Fas-associated phosphatase-1) was previously identified as a protein that associates with a negative regulatory domain (C-terminal 15 amino acids) of Fas using the yeast 2-hybrid system...
  79. ncbi Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation
    A A Kapasi
    Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Am J Physiol Renal Physiol 280:F333-42. 2001
    ..At a higher concentration, gp 120 not only promoted HMC apoptosis but also enhanced expression of Fas and FasL...
  80. ncbi HIV-1 Nef: negative effector of Fas?
    X N Xu
    Nat Immunol 2:384-5. 2001
  81. ncbi Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-1) in active lupus
    F Silvestris
    DIMO, Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Lupus 12:8-14. 2003
    ..apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of ..
  82. ncbi Resistance to fas-induced apoptosis in cells from human atherosclerotic lesions: elevated Bcl-XL inhibits apoptosis and caspase activation
    Zhaoqing Yang
    Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
    J Vasc Res 44:483-94. 2007
    ..genomic-scale transcript profiling of human carotid artery plaque cells with known sensitivity or resistance to fas-induced apoptosis identified candidate genes involved in lesion cell apoptosis...
  83. doi Soluble Fas: a useful marker of inflammation and cardiovascular diseases in uremic patients
    Amgad E El-Agroudy
    Urology and Nephrology Centre, University of Mansoura, Mansoura, Egypt
    Clin Exp Nephrol 14:152-7. 2010
    ..We therefore sought to investigate serum levels of sFas in uremic patients and its correlation with known markers of inflammation and CVD...
  84. ncbi Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
    José M Izquierdo
    Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid CBMSO UAM, Cantoblanco 28049 Madrid, Spain
    J Biol Chem 282:1539-43. 2007
    ..These proteins promote, for example, inclusion of Fas receptor exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor at the expense of the form ..
  85. ncbi Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
    R M Siegel
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 288:2354-7. 2000
    Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative syndrome...
  86. ncbi RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
    B Z Stanger
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 81:513-23. 1995
    Ligation of the extracellular domain of the cell surface receptor Fas/APO-1 (CD95) elicits a characteristic programmed death response in susceptible cells...
  87. ncbi APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death
    K Kelly
    The Huntsman Cancer Institute, Division of Molecular Pharmacology, Salt Lake City, Utah 84112, USA
    Cancer Res 60:1021-7. 2000
    ..In vitro binding experiments demonstrated that TRDL-1alpha coprecipitated Fas and HVEM and suggested TRDL-1alpha as an alternate ligand for these receptors. TRDL-1 localized to chromosome 17p13...
  88. ncbi Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1)
    D Kulms
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, D 48149 Munster, Germany
    Cell Death Differ 9:598-608. 2002
    Activation of the death receptor CD95 by its ligand or by UV radiation is associated with receptor clustering. The mechanism underlying this clustering is mostly unclear...
  89. ncbi Analysis of Fas (Apo-1/CD95) expression in non-small cell lung cancer
    Vincenzo Esposito
    Third Division of Infective Diseases, D Cotugno Hospital, Department of Cardiological, Respiratory and Thoracic Medical Sciences, Second University of Naples, Naples, Italy
    Anticancer Res 23:4901-5. 2003
    ..Fas (Apo-1/CD95) is a cell-surface receptor involved in cell death signaling...
  90. ncbi Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death
    P Matarrese
    Section of Cell Aging and Degeneration, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Cell Death Differ 12:932-41. 2005
    ..In fact, HIV protein gp120 is able to induce cytoskeleton-driven polarization, thus sensitizing T cells to CD95/Fas-mediated apoptosis...
  91. ncbi The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
    N Itoh
    Osaka Bioscience Institute, Japan
    Cell 66:233-43. 1991
    Mouse anti-Fas monoclonal antibody has a cytolytic activity on human cells that express the antigen. Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells...
  92. ncbi Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
    T Brunner
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, California 92037
    Nature 373:441-4. 1995
    ..Here we show that the Fas/CD95 receptor, which can transduce a potent apoptotic signal when ligand, is rapidly expressed following activation of T-..
  93. ncbi Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity
    K Grønbaek
    Department of Tumor Cell Biology, Institute of Cancer Biology, Danish Cancer Society the Departments of Pathology and Hematology, Herlev Hospital and the Departments of Hematology and Pathology, Rigshospitalet, Copenhagen, Denmark
    Blood 92:3018-24. 1998
    Fas (APO-1/CD95) is a cell-surface receptor involved in cell death signaling...
  94. ncbi Fas and Fas ligand gene polymorphisms in primary Sjögren's syndrome
    A I Bolstad
    Broegelmann Research Laboratory, Center for Medical Genetics and Molecular Medicine, Institute of Medicine, Haukeland University Hospital, Bergen, Norway
    J Rheumatol 27:2397-405. 2000
    To screen for polymorphisms in the apoptosis regulating Fas and Fas ligand (FasL) genes in patients with primary Sjögren's syndrome (SS), and to explore associations with susceptibility to the disease.
  95. ncbi Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in systemic lupus erythematosus
    Y H Lee
    Department of Internal Medicine, College of Medicine, Korea University, Seoul
    J Rheumatol 28:2008-11. 2001
    To evaluate whether the polymorphism of Fas promoter -670 is associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and their clinical features.
  96. ncbi Analysis of FAS (CD95) gene mutations in higher-grade transformation of follicle center lymphoma
    Bao Do
    Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94304, USA
    Leuk Lymphoma 44:1317-23. 2003
    The FAS antigen (CD95/APO-1) is suggested to be a tumor suppressor gene since mice and patients with congenital FAS mutations are prone to B cell lymphomas and somatic FAS mutations are described in hematological and solid tumors...
  97. ncbi CD95 polymorphisms are associated with susceptibility to MS in women. A population-based study of CD95 and CD95L in MS
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic and Foundation, 200 First Street, SW, Rochester, MN 55905, USA
    J Neuroimmunol 146:162-70. 2004
    b>CD95/CD95L interaction results in activation-induced apoptosis thereby regulating clonal expansion of T cells outside the thymus. Genetic defects in this system result in autoimmune lymphoproliferation in mice and men...
  98. ncbi Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death
    Jagan R Muppidi
    Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 5:182-9. 2004
    Clonotypic elimination of activated T cells through Fas-Fas ligand (CD95-CD95L) interactions is one mechanism of peripheral self-tolerance...
  99. ncbi Fas polymorphisms are associated with the presence of anti-ganglioside antibodies in Guillain-Barre syndrome
    Karin Geleijns
    Department of Neurology, Erasmus MC, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    J Neuroimmunol 161:183-9. 2005
    ..In this study we assessed whether polymorphisms in the promoter region of Fas and FasL and sFas and sFasL are related to GBS or its distinct clinical or serological subgroups...
  100. doi Elevated Fas expression is related to increased apoptosis of circulating CD8+ T cell in patients with gastric cancer
    Toshiaki Yoshikawa
    Department of Surgery, Division of Surgical Oncology, Tottori University School of Medicine, Yonago, Japan
    J Surg Res 148:143-51. 2008
    ..The present study was designed to investigate the correlation between apoptosis levels and Fas expression in CD8+ T lymphocytes in patients with gastric cancer.
  101. doi Raft component GD3 associates with tubulin following CD95/Fas ligation
    Maurizio Sorice
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    FASEB J 23:3298-308. 2009
    In a previous investigation, we demonstrated that after CD95/Fas triggering, raft-associated GD3 ganglioside, normally localized at the plasma membrane of T cells, can be detected in mitochondria, where they contribute to apoptogenic ..

Research Grants72

  1. Fas Internalization and Beta Cells
    Marcus Peter; Fiscal Year: 2003
    ..Among other factors, the Fas ligand (FasL) as been shown to contribute to the destruction of islets...
  2. David N Zacks; Fiscal Year: 2014
    ..Many consequences result from retinal-RPE separation including the FAS-mediated death of photoreceptors...
  3. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ..Activated allogeneic T lymphocytes express Fas-ligand (CD178), which crosslinks Fas receptor (CD95), prominently expressed on hepatocytes, thereby inducing hepatic injury...
  4. RIPK1: A new target for traumatic brain injury?
    Michael J Whalen; Fiscal Year: 2013
    ..and selective small molecule inhibitors of "necroptosis", a form of programmed necrosis initiated by TNF alpha and Fas receptor...
  5. Role of Stress-Response Protein gp96 in the Persistence of Rheumatoid Arthritis
    Richard M Pope; Fiscal Year: 2012
    ..We recently demonstrated that mice expressing a mutant Fas receptor (lpr), developed less frequent and less severe collagen induced arthritis (CIA)...
  6. Protection of vaccine immunity by inhibiting Fas/FasL signaling
    Maria S Salvato; Fiscal Year: 2010
    ..It is our hypothesis that treatment with small molecules that block Fas/FasL signaling could prevent the destruction of antigen-presenting-cells (APC), and allow the development of ..
  7. Prevention of photoreceptor cell death with intravitreal Fas-receptor antagonist
    Jeffrey A Jamison; Fiscal Year: 2012
    ..ONL Therapeutics is developing a product candidate, a novel small peptide inhibitor of the Fas receptor (ONL-101), for peri-operative adjunctive use in patients with acute retinal detachment (an orphan ..
  8. SERGE E PRZEDBORSKI; Fiscal Year: 2016
    ..mechanism(s) through which MMP-9 triggers motor neuron degeneration, focusing on candidate pathways involving the Fas receptor and glutamate excitotoxicity...
  9. Qun Lu; Fiscal Year: 2014
    ..two potential molecular mechanisms (ERM protein activation and redistribution to actin to activate Fas receptor/CD95 and SRF-dependent gene transcription) by which suppression of Rho GTPase signaling pathway protects neurons from ..
  10. Michael J Whalen; Fiscal Year: 2016
    ..cellular injury and death;plasmalemma permeability after ICH is reduced by 50% in mice deficient in TNF alpha and Fas receptor;necrotic-like cell death, assessed by EM, histological, and biochemical criteria occurs after ICH;and PI+ ..
  11. Cancer Cell Overexpression of Death Receptor Modulator
    Felipe Samaniego; Fiscal Year: 2013
    ..well-orchestrated coordination of signaling pathways, including that of the apoptosis-inducing cell death receptor Fas. Apoptotic signaling mediated by Fas eliminates autoreactive and controls the expansion of activated lymphocytes...
  12. DARREN F BOEHNING; Fiscal Year: 2016
    ..receptors (IP3Rs) regulates cell death in response to multiple stimuli, including engagement of the Fas receptor...
  13. FAS ANTIGEN AND OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2000
    ..The Fas antigen is a transmembrane receptor which triggers apoptosis (a form of programmed cell death)...
  14. DYSREGULATION OF APOPTOSIS IN LGL LEUKEMIA
    Thomas Loughran; Fiscal Year: 2000
    ..Altered expression of Fas receptor (Fas) and Fas ligand is associated with lymphoproliferative and autoimmune diseases in preclinical models...
  15. NOVEL FAS BINDING PROTEIN AND ITS ROLE IN DISEASE
    Raif Geha; Fiscal Year: 1999
    b>Fas is a cell surface molecule which transduces a signal that results in apoptosis. Fas has been implicated in the removal of self reactive T and B cells and in the maintenance of self tolerance...
  16. REGULATION OF EOSINOPHIL SURVIVAL
    Anne Sperling; Fiscal Year: 2004
    ..Preliminary results have found that Fas (CD95), a cell surface receptor that when ligated can induce cell death via apoptosis, is an important mechanism of ..
  17. "Enhancement of Brain Tumor Immunotherapy by Fas-L RNAi"
    Alessandro Olivi; Fiscal Year: 2006
    ..Gliomas seem to be capable of inducing T-cell apoptosis through the Fas/Fas-ligand (Fas-L) pathway...
  18. "Enhancement of Brain Tumor Immunotherapy by Fas-L RNAi"
    Alessandro Olivi; Fiscal Year: 2009
    ..Gliomas seem to be capable of inducing T-cell apoptosis through the Fas/Fas-ligand (Fas-L) pathway...
  19. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..induces apoptosis of CD45+ lung leukocytes;apoptosis is controlled largely by tumor necrosis factor (TNF)-1 and Fas-Fas ligand interaction...
  20. Andrew M Thorburn; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Fas Associated Death Domain (FADD) is an adaptor protein that is required for signaling by the Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) receptors...
  21. Clayton E Mathews; Fiscal Year: 2015
    ..and primary islets resist destruction mediated by members of the Tumor Necrosis Factor Receptor family, TNFR1 and Fas. Aim 2 will extend the studies to determine the mechanisms utilized by mt-Nd2a encoding islet cells to avert lysis ..
  22. DEQUINA ANGELINA NICHOLAS; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Dietary saturated fatty acids (FAs), such as palmitic acid (PA), play a major role in inflammation- associated disease...
  23. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2011
    ..encoding beta cells resist destruction mediated by members of the Tumor Necrosis Factor Receptor family, TNFR1 and Fas. Aim 2 will extend the studies to determine the mechanisms utilized by NIT-4 cells to avert lysis by CTL...
  24. Fatal Attration: T lymphocytes and liver endothelial cell during sepsis.
    NOELLE A HUTCHINS; Fiscal Year: 2012
    ..expressing CD31 (an endothelial cell marker) in the non-parenchymal cell population exhibit an increased level of Fas following cecal ligation and puncture (CLP), a surgical procedure to induce sepsis...
  25. Mechanisms of CD8+ T Cell Apoptosis During Acute and Chronic Viral Infections
    JASON MITCHELL GRAYSON; Fiscal Year: 2010
    ..Activated CD8+ T cells are also susceptible to apoptosis through death receptors such as Fas, Tumor Necrosis Factor Receptor I (TNFRI) or Tumor necrosis factor Related Apoptosis Ligand-Receptor (TRAIL-R)...
  26. C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    Mario Chojkier; Fiscal Year: 2012
    ..mimic C/EBPI3Glu 2_zmutant blocks hepatocyte apoptosis initiated by death receptors or proteasome inhibitors (FAS/caspase 8 pathway). The specific aims of this proposal are to assess: 1...
  27. Engineering tyrosine kinase-activated caspases for selective cancer cell killing
    SALLY A KORNBLUTH; Fiscal Year: 2013
    ..caspase 8) can be activated in a fairly direct manner by receptor binding of extracellular "death ligands" such as Fas and TNF, caspase activation in response to damaging agents (radiation, chemotherapeutics) typically proceeds ..
  28. Novel Fas/CD95 Signaling Mechanisms
    Marcus E Peter; Fiscal Year: 2011
    The death receptor Fas (CD95/APO-1) mediates apoptosis in many tissues...
  29. Dissecting the Molecular Pathway of Aponecrosis
    Junying Yuan; Fiscal Year: 2005
    ..Aponecrosis is defined as caspase-independent cell death induced by the death receptors such as Fas and TNFalpha receptors...
  30. Huaizhu Wu; Fiscal Year: 2016
    ..with increased hepatic production of triglyceride-rich lipoproteins (TGRLs) and increased levels of fatty acids (FAs, saturated FAs in particular). Current data suggest that these changes activate leukocytes in blood and AT...
  31. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ..One feasible change may be by altering the type of fat consumed in the diet. Consumption of omega 3 fatty acids (FAs) is usually associated with a lower incidence of breast cancer whereas exposure to high omega 6 fatty acids during ..
  32. Massimo Loda; Fiscal Year: 2016
    ..Prostate adenocarcinomas (PCa) overexpressing FAS display aggressive biologic behavior, suggesting that FAS overexpression confers a selective growth advantage...
  33. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..It may also help understanding why in some very poor regions of South Africa the prevalence of FAS is much higher than in Western countries as these populations also experience severe malnutrition.
  34. Genes required for lipid processing and digestive organ function in larval zebraf
    Steven A Farber; Fiscal Year: 2011
    ..To this end, we have developed an animal model of dietary fat (triacylglycerol) metabolism that can track FAs from their site of absorption at the intestinal brush border of 6-day old zebrafish larvae, through the circulatory ..
  35. Patrick Tso; Fiscal Year: 2015
    ..1) We will study the in vitro effects of different types of FAs on rat basophil leukemia cells (RBL-2H3 cells, a surrogate of the rat MMC) activation through NF-kB signaling ..
  36. Mode of Action of Thiorcarlide in Mycobacterium Tuberculosis
    Mary Jackson; Fiscal Year: 2012
    ..no inhibitory effect on mycolic acid synthesis in Corynebacterium and Nocardia species and on the activity of the FAS-I and FAS-II systems from Mycobacterium aurum, the second target of the drug is likely to differ from that of other ..
  37. Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance &Obesity
    LIZA MAKOWSKI HAYES; Fiscal Year: 2012
    ..2: Mitochondrial Processing of FAs is Necessary to Drive the MP Inflammatory Response...
  38. Jack T Stapleton; Fiscal Year: 2016
    ..Specifically, two viral proteins (nonstructural protein 5A and envelope glycoprotein E2) inhibit Fas-mediated apoptosis in lymphocyte cell lines...
  39. Chronic ethanol, B cell competence and lymphoid integrity
    Thomas J Waldschmidt; Fiscal Year: 2010
    ..In addition to immune deficiency caused by extended ethanol intake, children with fetal alcohol syndrome (FAS) also display immunologic deficits and higher infection rates...
  40. MUKESH KUMAR JAIN; Fiscal Year: 2016
    ..studies link KLF2 to the action of clinically relevant anti-inflammatory agents such as omega-3 fatty acids (w-3 FAs)...
  41. INTERPLAYS BETWEEN THE JAW MESENCHYMAL STEM CELLS AND T LYMPHOCYTES
    Yufang Shi; Fiscal Year: 2010
    ..While our preliminary studies revealed that activated T cells are capable of inducing BMMSC apoptosis through the Fas/FasL pathway, suggesting a novel crosstalk mechanism between T cells and BMMSCs...
  42. Jia Luo; Fiscal Year: 2016
    ..during pregnancy may cause Fetal Alcohol Spectrum Disorders (FASD), among which, fetal alcohol syndrome (FAS) is the most severe form...
  43. Effect of FADS gene variants on fatty acid synthesis &brain development in India
    AVINASH KUNJAN SHETTY; Fiscal Year: 2013
    ..sits geographically between populations to the east that have the alleles that facilitate the conversion of MC-FAs to LC-PUFAs and populations to the west of that have little capacity for conversion...
  44. The Role of Visceral Fatty Acids in Relation to Insulin Resistance
    Michelle T Foster; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary / Abstract Chronic exposure of the liver to elevated FAs, as occurs on a high-fat diet (HFD), promotes liver gluconeogenesis, reduces enzymes of FA oxidation and increases hepatic ..
  45. Epigenetic Effects of Prenatal Ethanol Exposure
    Thomas P Yang; Fiscal Year: 2010
    Fetal alcohol syndrome (FAS) is a significant cause of mental retardation and birth defects worldwide...
  46. SUNEIL KRISHNA KOLIWAD; Fiscal Year: 2014
    ..important biomedical question of how MCs contend with pro-inflammatory lipids, in particular saturated fatty acids (FAs)...
  47. RACHAEL LOUISE FRENCH; Fiscal Year: 2016
    ..In humans, these symptoms are collectively described as fetal alcohol syndrome (FAS)...
  48. Xinhua Chen; Fiscal Year: 2016
    ..Because circulating FFAs are well correlated with dietary fat/FAs intake, modification in the type or amount of fat in the diet will alter circulating FFAs levels, likely reducing ..
  49. The Role of GPR120 and Omega-3 Fatty Acids in Steatosis and Systemic Inflammation
    Sarah Carlson; Fiscal Year: 2013
    ..Omega-3 FAs are metabolized to eicosapenaenoic acid (EPA) and docosahexaenoic acid (DHA), which increase the anti-inflammatory ..
  50. Understanding the influence of n-3 PUFA on pro-inflammatory aspects of mercury
    Allen J Rosenspire; Fiscal Year: 2013
    ..However we have previously shown that one consequence of low-level Hg intoxication is that Fas (CD95) mediated signal transduction and activation induced cell death (AICD) in the immune system is depressed...
  51. ANDREW MARTIN ROLLINS; Fiscal Year: 2016
    ..We have chosen to focus on the connections between the etiology of CHDs associated with Fetal Alcohol Syndrome (FAS), NCCs, and their ability to influence cardiac function from an early stage...
  52. Clay F Semenkovich; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Fatty acid synthase (FAS) synthesizes palmitate and other fatty acids. In adults, FAS has not been thought to be physiologically important...
  53. HUMAN GENETIC VARIATION IN FATTY ACID METABOLISM AND SUDDEN CARDIAC ARREST
    DAVID STUART SISCOVICK; Fiscal Year: 2012
    ..Fatty acid metabolism is complex with multiple determinants of membrane FAs and intracellular FA derivatives, and multiple effects, cell membrane-dependent and membrane independent, that ..
  54. Katsuhiko Funai; Fiscal Year: 2016
    ..The preliminary evidence in cell culture suggests that CEPT1, like FAS, contributes to SR PE content to alter calcium flux...
  55. Fetal Postnatal Regulation of Expression of the GH Receptor
    Ram K Menon; Fiscal Year: 2010
    ..preliminary observations by the pursuing the following SPECIFIC AIMS: Specific Aim 1 tests the hypothesis that FAs modulate the expression of the GHR gene expression in DM in a tissue-specific manner...
  56. KATHLEEN ELIZABETH JAEGER; Fiscal Year: 2014
    ..by applicant): In addition to the neuropsychological and behavioral disorders inherent in fetal alcohol syndrome (FAS), significant impairments in immune function have been identified in these patients...
  57. William B Kinlaw; Fiscal Year: 2016
    ..that, in addition to the "lipogenic" apparatus, tumors are equipped to acquire circulating, diet-derived FAs using a "lipolytic" pathway...
  58. A Heather Eliassen; Fiscal Year: 2015
    ..We will further investigate this association with tumor over-expression of fatty acid synthase (FAS)...
  59. The fuel sensing enzyme AMPK in the pathogenesis of prostate cancer
    Zhijun Luo; Fiscal Year: 2010
    ..We have also found that these effects are associated with inhibition of fatty acid synthase (FAS), acetyl CoA carboxylase (ACC) and mTOR...
  60. SKELETAL MUSCLE DE NOVO LIPOGENESIS AND THE GLUCOSE-FATTY ACID CYCLE
    Katsuhiko Funai; Fiscal Year: 2012
    ..laboratory successfully generated and characterized mice with tissue-specific deletion of fatty acid synthase (FAS) and provided evidence that de novo-generated lipids have distinct signaling roles in multiple tissues...
  61. Fatty Acid Synthase, Caveolin-1 and Membrane Microdomains in Prostate Cancer
    Dolores Di Vizio; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Fatty Acid Synthase (FAS), a major lipogenic enzyme, and Caveolin-1 (Cav-1), a membrane protein that transports cholesterol and regulates signal transduction, are both over-expressed in human and ..
  62. Jingwen Liu; Fiscal Year: 2015
    ..Although the mechanisms that regulate the hepatic uptake, activation, and metabolism of fatty acids (FAs) are not fully understood, nearly all pathways of FA metabolism require conversion of FAs to acyl-CoAs by acyl-CoA ..
  63. NFkB Targets and Neural Crest Development
    MICHAEL WILLIAM KLYMKOWSKY; Fiscal Year: 2010
    ..crest underlie the neurological, craniofacial, and dental malformations associated with Fetal Alcohol Syndrome (FAS) and the less severe, but still significant alcohol-related neurodevelopmental disorder (ARND) and alcoholrelated ..
  64. Ethanol and Bcl-2 Gene Interactions in the Developing CNS
    Marieta B Heaton; Fiscal Year: 2012
    ..Such exposure can lead to the fetal alcohol syndrome (FAS) or alcohol-related birth defects (ARBD)...
  65. IMMUNOPATHOGENESIS OF LUPUS
    Charles S Via; Fiscal Year: 2012
    ..Sub-aims will evaluate whether perforin or Fas dominates. Aim 2. Determine whether promoting CTL longevity by blocking downregulation will prevent lupus...
  66. Molecular mechanism of ADNF and ADNP peptides in prevention of mitochondrial dysf
    Youssef Sari; Fiscal Year: 2010
    ..In a model of fetal alcohol syndrome (FAS), these peptides have been shown to prevent alcohol-induced decreases in reduced mitochondrial glutathione...
  67. Andrey Finegersh; Fiscal Year: 2015
    ..These findings will be important for studying transgenerational inheritance of behaviors in the following generation. Our findings may also reveal new epigenetic targets for the treatment of alcoholism and fetal alcohol syndrome (FAS).
  68. NO-mediated neuroprotection against alcohol toxicity
    Nicholas J Pantazis; Fiscal Year: 2010
    Fetal alcohol syndrome (FAS) is an important cause of mental retardation...
  69. CLINICAL INVESTIGATIONS IN LGL LEUKEMIA
    Thomas Loughran; Fiscal Year: 2004
    ..Altered expression of Fas receptor (Fas) and Fas ligand is associated with lymphoproliferative and autoimmune diseases in animal models...
  70. ROLE OF THE FAS ANTIGEN IN OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2004
    ..Our previous work demonstrated the presence of a functional Fas antigen (Fas) pathway in the ovarian follicle...
  71. Naltrexone and AIDS progression
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..CD8+ T cells will be determined by a polychromatic flow cytometry panel that includes antibodies to CD3, CD4, CD28, CD95, CCR7, CCR5, CD69, HLA-DR and PD-1, and monitored every 2 weeks...
  72. Fatty Acid Synthase Inhibitors: Ovarian Cancer Therapy
    ALBERT OWENS; Fiscal Year: 2007
    ..FASgen, Inc. is developing a novel set of antineoplastic agents, inhibitors of the enzyme fatty acid synthase (FAS), which is overproduced in 50-80% of ovarian cancers...