FAK

Summary

Gene Symbol: FAK
Description: protein tyrosine kinase 2
Alias: FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, focal adhesion kinase 1, FADK 1, FAK-related non-kinase polypeptide, PTK2 protein tyrosine kinase 2, focal adhesion kinase isoform FAK-Del33, focal adhesion kinase-related nonkinase, protein phosphatase 1 regulatory subunit 71
Species: human

Top Publications

  1. ncbi Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines
    Vita M Golubovskaya
    Department of Surgery, University of Florida, Gainesville, FL 32610 0286, USA
    Mol Cancer Res 1:755-64. 2003
  2. ncbi Integrin-regulated FAK-Src signaling in normal and cancer cells
    Satyajit K Mitra
    The Scripps Research Institute, Department of Immunology, IMM21 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 18:516-23. 2006
  3. ncbi Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer
    L V Owens
    Department of Surgery, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Ann Surg Oncol 3:100-5. 1996
  4. pmc Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
    Ssang Taek Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC0803, La Jolla, CA 92093, USA
    Mol Cell 29:9-22. 2008
  5. pmc Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000520. 2009
  6. ncbi Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas
    T Noguchi
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:15216-24. 2001
  7. pmc Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer
    Yu Kang
    Affiliations of authors Department of Gynecologic Oncology and Repro ductive Medicine YK, WH, CI, CVP, HJD, BZ, TL, JH, NBJ, RR, MT, TM, SP, SYW, CL, YW, AKS, Center for RNAi and Non Coding RNA CI, AKS, Department of Pathology JH, Jl, and Department of Cancer Biology AKS, The University of Texas MD Anderson Cancer Center, Houston, TX Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College of Fudan University, Shanghai, China YK Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China TL
    J Natl Cancer Inst 105:1485-95. 2013
  8. doi MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway
    Kaihuan Ren
    Department of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    J Biol Chem 283:35598-605. 2008
  9. ncbi Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway
    Xu Wen Liu
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:40364-72. 2003
  10. pmc Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
    M C Brown
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Syracuse, 13210, USA
    J Cell Biol 135:1109-23. 1996

Research Grants

  1. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
  2. David D Schlaepfer; Fiscal Year: 2016
  3. Role of p190RhoGEF (Rgnef) in cell motility and tumor progression
    Nichol L G Miller; Fiscal Year: 2013
  4. Jun Lin Guan; Fiscal Year: 2016
  5. The role of Vimentin in cell adhesion and lung cancer metastasis
    LAUREN SMITH HAVEL; Fiscal Year: 2013
  6. Timothy A Springer; Fiscal Year: 2015
  7. Directed growth cone migration by calcium signals
    James Q Zheng; Fiscal Year: 2011
  8. Frank A Anania; Fiscal Year: 2016
  9. Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte Death
    Abdelkarim Sabri; Fiscal Year: 2012
  10. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010

Detail Information

Publications284 found, 100 shown here

  1. ncbi Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines
    Vita M Golubovskaya
    Department of Surgery, University of Florida, Gainesville, FL 32610 0286, USA
    Mol Cancer Res 1:755-64. 2003
    Focal adhesion kinase (FAK) and Src have been shown to be overexpressed in colon cancer. We have studied the role of these two kinases in resistance to apoptosis...
  2. ncbi Integrin-regulated FAK-Src signaling in normal and cancer cells
    Satyajit K Mitra
    The Scripps Research Institute, Department of Immunology, IMM21 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 18:516-23. 2006
    ..and activation of signaling proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c-Src that form a dual kinase complex...
  3. ncbi Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer
    L V Owens
    Department of Surgery, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Ann Surg Oncol 3:100-5. 1996
    The FAK gene encodes a 125-kDa tyrosine kinase (p125FAK) involved in signal transduction pathways used in cell adhesion, motility, and anchorage-independent growth...
  4. pmc Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
    Ssang Taek Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC0803, La Jolla, CA 92093, USA
    Mol Cell 29:9-22. 2008
    b>FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest...
  5. pmc Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000520. 2009
    ..In this review, we summarize past and present studies on HIV coreceptor signaling. We also discuss possible roles of coreceptor signaling in facilitating viral infection and pathogenesis...
  6. ncbi Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas
    T Noguchi
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:15216-24. 2001
    ....
  7. pmc Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer
    Yu Kang
    Affiliations of authors Department of Gynecologic Oncology and Repro ductive Medicine YK, WH, CI, CVP, HJD, BZ, TL, JH, NBJ, RR, MT, TM, SP, SYW, CL, YW, AKS, Center for RNAi and Non Coding RNA CI, AKS, Department of Pathology JH, Jl, and Department of Cancer Biology AKS, The University of Texas MD Anderson Cancer Center, Houston, TX Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College of Fudan University, Shanghai, China YK Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China TL
    J Natl Cancer Inst 105:1485-95. 2013
    We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well understood.
  8. doi MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway
    Kaihuan Ren
    Department of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    J Biol Chem 283:35598-605. 2008
    ..Following down-regulation of MR-1, the phosphorylations of MLC2, focal adhesion kinase (FAK), and Akt were dramatically decreased, and the formation of stress fiber was destroyed by MR-1-siRNAs in hepatoma ..
  9. ncbi Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway
    Xu Wen Liu
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:40364-72. 2003
    ..Taken together, the present study unveils some of the mechanisms mediating the anti-apoptotic effects of TIMP-1 in human breast epithelial cells through TIMP-1-specific signal transduction pathways...
  10. pmc Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
    M C Brown
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Syracuse, 13210, USA
    J Cell Biol 135:1109-23. 1996
    ..transforming protein v-crk, and the cytoskeletal proteins vinculin and the tyrosine kinase, focal adhesion kinase (FAK)...
  11. ncbi Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
    Timothy P Hecker
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 23:3962-71. 2004
    Focal adhesion kinase (FAK) signaling may be mediated through the modulation of Ras activity...
  12. ncbi P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910
    Liang Hui Li
    Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Int J Oncol 37:951-62. 2010
    ..Importantly, activated Pak1 elicited phosphorylation of FAK at Ser-910 via an ERK-dependent pathway in colorectal cancer cell lines and clinical samples...
  13. pmc A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonog
    Vita M Golubovskaya
    Department of Surgical Oncology, Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 33:1004-13. 2012
    Focal adhesion kinase (FAK) is a protein tyrosine kinase that is overexpressed in most solid types of tumors and plays an important role in the survival signaling...
  14. pmc Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression
    Ssang Taek Lim
    Department of Reproductive Medicine, University of California San Diego, Moores Cancer Center, La Jolla, CA 92093, USA
    J Cell Biol 197:907-19. 2012
    ..Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively...
  15. doi Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules
    Shi Quan Liu
    Department of Gastroenterology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Autonomous Region 530021, P R China
    Int J Oncol 42:617-26. 2013
    ..Moreover, the focal adhesion kinase (FAK) pathway and the expression of intercellular adhesion molecule‑1 (ICAM‑1) and vascular cell ..
  16. pmc MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells
    Shivani Ponnala
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
    Cell Signal 23:2065-75. 2011
    ..MMP-9 transcriptional suppression decreased the expression of FAK, phospho FAK and β1 integrin in glioma xenograft cells...
  17. pmc Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST
    Yanhua Zheng
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell Biol 31:4258-69. 2011
    ..Isomerization of the phosphorylated PTP-PEST by PIN1 increases the interaction between PTP-PEST and FAK, which leads to the dephosphorylation of FAK Y397 and the promotion of migration, invasion, and metastasis of v-H-..
  18. ncbi Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples
    Timothy P Hecker
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 62:2699-707. 2002
    Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that on activation generates signals that can modulate crucial cell functions, including cell proliferation, migration, and survival...
  19. pmc Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)
    Guorong Li
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:17129-34. 2011
    ..that DLC1 forms a complex with two prooncogenic focal adhesion proteins, talin and the focal adhesion kinase (FAK)...
  20. pmc Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility
    Alok Tomar
    Department of Reproductive Medicine, Moores Cancer Center, University of California San Diego, CA, USA
    Curr Opin Cell Biol 21:676-83. 2009
    Focal adhesion (FA) kinase (FAK) is a cytoplasmic protein-tyrosine kinase involved in cytoskeleton remodeling, formation and disassembly of cell adhesion structures, and in the regulation of Rho-family GTPases...
  21. pmc Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase
    C Guinebault
    Institut National de la Sante et de la Recherche Medicale, Unité 326, Hopital Purpan, Toulouse, France
    J Cell Biol 129:831-42. 1995
    ..Actually, PtdIns(3,4)P2 accumulation and PtdIns 3-kinase, pp60c-src, and p125FAK translocations as well as aggregation were concomitant events occurring with a distinct lag after actin ..
  22. ncbi Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line
    Seiichi Okabe
    Department of Microbiology Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 30:761-6. 2002
    ..To evaluate mechanisms that might be involved in migration of T cells, we examined effects of stromal cell-derived factor (SDF)-1alpha on WASP and associated proteins...
  23. ncbi Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation
    Shingo Nakayamada
    First and Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, 807 8555, Japan
    J Biol Chem 278:45368-74. 2003
    ..genistein, tyrosine kinase inhibitors, or transfection of dominant negative truncations of focal adhesion kinase (FAK)...
  24. ncbi Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5
    Roman M Salasznyk
    Department of Biology, Rensselaer Polytechnic Institute, Troy, New York 12180 3596, USA
    J Cell Biochem 100:499-514. 2007
    ..We hypothesized that focal adhesion kinase (FAK) mediated signaling pathways supply a link between cell surface integrin-ECM binding and activation of ERK 1/2, and ..
  25. pmc Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase
    Kelly M Bailey
    Mary Babb Randolph Cancer Center, Morgantown, West Virginia, USA
    J Biol Chem 283:13714-24. 2008
    ..both cell lines following the induction of EMT and was preceded by increased activation of focal adhesion kinase (FAK) and Src, two known tyrosine kinases involved in EMT...
  26. pmc Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness
    Emy Behmoaram
    Department of Pathology, Lady Davis Institute of the Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Pathol 173:1540-50. 2008
    ..Key regulators include the focal adhesion kinase (FAK) and FAK-related proline-rich tyrosine kinase 2 (Pyk2), whose distinct functions in cancer progression remain ..
  27. doi NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production
    Yi Qun Kuang
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Eur J Immunol 42:299-310. 2012
    ..NHERF1 overexpression also increases HIV-1 host cell migration triggered by gp120 via focal adhesion kinase (FAK) signaling...
  28. pmc Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin
    S L Bellis
    Department of Anatomy and Cell Biology, State University of New York Health Science Center, 750 E Adams Street, Syracuse, NY 13210, USA
    Biochem J 325:375-81. 1997
    Tyrosine phosphorylation of paxillin by the focal adhesion kinase (FAK) has been implicated as a signal transduction mechanism associated with cell adhesion and cytoskeletal reorganization...
  29. ncbi Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C
    J F Wang
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 95:2505-13. 2000
    ..We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and Crk-L, are phosphorylated on SDF-1alpha stimulation...
  30. ncbi Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis
    Yuji Tamagiku
    Department of Biochemistry, Kyoritsu University of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
    Biochem Biophys Res Commun 323:445-52. 2004
    We have demonstrated that focal adhesion kinase (FAK)-overexpressed (HL-60/FAK) cells have marked resistance against various apoptotic stimuli such as hydrogen peroxide, etoposide, and ionizing radiation compared with the vector-..
  31. ncbi Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
    Vita M Golubovskaya
    Departments of Surgery and Biochemistry and Molecular Biology, University of Florida, School of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 280:25008-21. 2005
    Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors and associates with multiple cell surface receptors and intracellular signaling proteins through which it can play an important role in ..
  32. pmc Focal adhesion kinase, a downstream mediator of Raf-1 signaling, suppresses cellular adhesion, migration, and neuroendocrine markers in BON carcinoid cells
    Li Ning
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin School of Medicine and Public Health and University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA
    Mol Cancer Res 8:775-82. 2010
    ..report that activation of the Raf-1 signaling cascade in BON cells induced the expression of focal adhesion kinase (FAK) protein, suppressed the production of neuroendocrine markers, and resulted in significant decreases in cellular ..
  33. doi Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition
    T H Chen
    Department of Life Science, National Chung Hsing University, Taichung, Taiwan
    Oncogene 30:153-66. 2011
    Focal adhesion kinase (FAK) has a crucial role in integration of signals from integrins and growth factor receptors...
  34. doi Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer
    Hong fei Ji
    Cancer Institute of Heilongjiang Province, Harbin Medical University, Harbin 150081, China
    J Cancer Res Clin Oncol 139:429-35. 2013
    The aim of this study was to investigate whether focal adhesion kinase (FAK) overexpression correlates with lymph node metastases and prognosis.
  35. ncbi The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase
    G Izaguirre
    Department of Surgery, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    J Biol Chem 276:28676-85. 2001
    ..The wild type recombinant protein was not phosphorylated in cells lacking the focal adhesion kinase (FAK). Re-expression of FAK in these cells restored alpha-actinin phosphorylation...
  36. pmc Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase
    M Fresu
    Department of Experimental Pathology, University of Pisa, Via Roma 55 56126 Pisa, Italy
    Biochem J 358:407-14. 2001
    ..The association was confirmed by the ability to GST-FAK-related non-kinase (FRNK) to pull-down PP1delta from fibroblasts extract...
  37. ncbi Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts
    Megumi Funakoshi-Tago
    Department of Biochemistry, Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    J Biol Chem 278:29359-65. 2003
    Focal adhesion kinase (FAK) is widely involved in important cellular functions such as proliferation, migration, and survival, although its roles in immune and inflammatory responses have yet to be explored...
  38. pmc FAK nuclear export signal sequences
    Valeria Ossovskaya
    Department of Anatomy, University of California San Francisco, San Francisco, CA, USA
    FEBS Lett 582:2402-6. 2008
    Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions...
  39. doi Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor
    Sandra Andersson
    Karolinska Institute, Department of Oncology and Pathology, Karolinska Hospital, Stockholm, Sweden
    Biochem Biophys Res Commun 387:36-41. 2009
    Recent studies have shown a direct association between IGF-1R and FAK, two important mediators of cell growth, survival and migration. However, the mechanism by which FAK affects IGF-1R function remains unknown...
  40. pmc Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport
    Italo Mocchetti
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road, NW, New Research Building WP13, Washington, DC 20057, USA
    Neurotox Res 21:79-89. 2012
    ..Moreover, these proteins have been shown to possess neurotoxic properties. This review describes new evidence of a direct interaction of the HIV protein gp120 with neurons, which might play a role in the etiopathology of HAND...
  41. ncbi Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)
    P Lebrun
    INSERM U145, Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Biol Chem 273:32244-53. 1998
    ..One of the major proteins implicated in integrin signaling is pp125(FAK), a cytosolic tyrosine kinase, which upon integrin engagement becomes tyrosine-phosphorylated and subsequently ..
  42. pmc Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734
    Andreas Wortmann
    Mater Medical Research Institute, Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia
    J Biol Chem 286:42303-15. 2011
    Reciprocal interactions between Src family kinases (SFKs) and focal adhesion kinase (FAK) are critical during changes in cell attachment...
  43. ncbi HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells
    D Milani
    Department of Morphology and Embriology, University of Ferrara, Italy
    AIDS 12:1275-84. 1998
    ..To evaluate the signal transduction potential of HIV-1 Tat in a neuronal cell model...
  44. ncbi Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation
    L Geng
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, Box 1243, 1 Gustave L Levy Place, 10029, New York, NY 10029, USA
    Biochim Biophys Acta 1535:21-35. 2000
    ..binding assays have shown that polycystin-1 associates with the focal adhesion proteins talin, vinculin, p130Cas, FAK, alpha-actinin, paxillin and pp60c-src in subconfluent normal human fetal collecting tubule (HFCT) epithelia when ..
  45. ncbi The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism
    Xiaodong Li
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Biol Chem 277:37788-97. 2002
    ..These studies provide evidence for an important role of mammalian Nck-1 in a novel signaling pathway from an extracellular guidance cue to changes in the actin-based cytoskeleton responsible for axonal guidance...
  46. doi B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms
    Véronique Bouchard
    Département d Anatomie et de Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Apoptosis 13:531-42. 2008
    ..To this effect, the roles of beta1 integrin/Fak/Src signaling to the PI3-K/Akt-1, MEK/Erk, and p38 pathways, were investigated...
  47. doi Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway
    Yung Cheng Chiu
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    J Immunol 183:2785-92. 2009
    ..PGN increased the focal adhesion kinase (FAK), PI3K, and Akt phosphorylation...
  48. pmc Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand
    F Liu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 18:250-9. 1998
    ..with the phosphorylation status of p130Cas and two proteins that are associated with p130Cas, Paxillin and Fak. Expression of WT-PTP1B reduces formation of p130Cas-Crk complexes and inhibits mitogen-activated protein kinase ..
  49. doi Mechanical stress modulates SOCS-1 expression in human vascular smooth muscle cells
    Marc Dangers
    Hannover Medical School, Hannover, Germany
    J Vasc Res 47:432-40. 2010
    ..The underlying molecular mechanisms are, however, not completely defined...
  50. pmc Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway
    Genevieve S Griffiths
    The Center for Cardiovascular Research and Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    J Biol Chem 286:14713-23. 2011
    ..Thus, we have elucidated an integrin-controlled pathway in which Bit-1 is, in part, responsible for the survival effects of cell-ECM interactions...
  51. ncbi Focal adhesion kinase in netrin-1 signaling
    Xiu Rong Ren
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    Nat Neurosci 7:1204-12. 2004
    ..we report that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion kinase (FAK), a kinase implicated in regulating cell adhesion and migration...
  52. pmc Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas
    T R Polte
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 92:10678-82. 1995
    The focal adhesion kinase (FAK) has been implicated in integrin-mediated signaling events and in the mechanism of cell transformation by the v-Src and v-Crk oncoproteins...
  53. pmc Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases
    M D Schaller
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 10:3489-505. 1999
    Tyrosine phosphorylation of focal adhesion kinase (FAK) creates a high-affinity binding site for the src homology 2 domain of the Src family of tyrosine kinases...
  54. ncbi Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin
    S C Even-Ram
    Departments of Oncology and Pharmacology at the Hadassah Hebrew University Hospital, Jerusalem 91120, Israel, The Department of Hematology, Medical Center, Tel Aviv 64239, Israel
    J Biol Chem 276:10952-62. 2001
    ..We propose that the activation of PAR1 may lead to a novel cooperation with the alpha(v)beta(5) integrin that supports tumor cell invasion...
  55. ncbi beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway
    Bin Tian
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:24667-75. 2002
    ..Our data identify a novel role for beta1 integrin in regulating fibroblast viability through a PI3K/Akt/protein kinase B signaling pathway in response to a matrix-derived mechanical stimulus...
  56. ncbi Possible involvement of the vascular endothelial growth factor-Flt-1-focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints
    Yoshihiro Matsumoto
    Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 168:5824-31. 2002
    ..and VEGF treatment stimulated chemotaxis, cell proliferation, the association of Flt-1 with focal adhesion kinase (FAK), and the tyrosine phosphorylation of FAK in Raw cells...
  57. ncbi Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples
    Sorina Grisaru-Granovsky
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Int J Cancer 113:372-8. 2005
    ..In parallel, we analyzed the expression pattern of alphavbeta5 integrin and of activated focal adhesion kinase (FAK), a major focal contact protein, in these tissues...
  58. ncbi HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells
    Hava Karsenty Avraham
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    J Immunol 173:6228-33. 2004
    ..Focal adhesion kinase (FAK) was tyrosine-phosphorylated by Tat and was found to be an important component of focal adhesion sites...
  59. ncbi alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells
    Chiara Urbinati
    General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europe 11, 25123 Brescia, Italy
    J Cell Sci 118:3949-58. 2005
    ..Since Tat accumulates in an immobilized form in the extracellular matrix, these results provide new biochemical and biological insights about alpha(v)beta3/Tat interaction exploitable for the design of anti-Tat strategies...
  60. pmc Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1
    Urai Pongchairerk
    Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    World J Gastroenterol 11:5845-52. 2005
    To study the role of focal adhesion kinase (FAK) and its association with Src in hepatocyte growth factor (HGF)-induced cell signaling in cholangiocarcinoma progression.
  61. doi Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly
    Sebastien Vitale
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
    Eur J Cell Biol 87:569-79. 2008
    ..b>FAK is present with active Src at sites of matrix-degrading activity (invadopodia), specifically residing in rings ..
  62. pmc Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer
    Margarita Aponte
    Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Dana Farber Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 68:5839-48. 2008
    ..Using quantitative multiplex phospho-antibody array technology, we found that tyrosine phosphorylation of EGFR/Src/FAK/paxillin was coordinately activated by PAF treatment, which was correlated with the activation of ..
  63. pmc Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Cell Biol 15:954-63. 1995
    Focal adhesion kinase (FAK) is a widely expressed nonreceptor protein-tyrosine kinase implicated in integrin-mediated signal transduction pathways and in the process of oncogenic transformation by v-Src...
  64. pmc Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin
    S Kharbanda
    Division of Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 92:6132-6. 1995
    ..monocytes, we show that M-CSF induces interaction of the Grb2 adaptor protein with the focal adhesion kinase pp125FAK. The results demonstrate that tyrosine-phosphorylated pp125FAK directly interacts with the SH2 domain of Grb2...
  65. ncbi Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Nature 372:786-91. 1994
    The cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells attach to the extracellular matrix...
  66. pmc Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain
    Z Xing
    Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
    Mol Biol Cell 5:413-21. 1994
    The recently described focal adhesion kinase (FAK) has been implicated in signal transduction pathways initiated by cell adhesion receptor integrins and by neuropeptide growth factors...
  67. pmc Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae
    S F Law
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 16:3327-37. 1996
    ..We anticipate that HEF1 may prove to be an important linking element between extracellular signalling and regulation of the cytoskeleton...
  68. ncbi p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene
    R Salgia
    Division of Hematologic Malignancies, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:25198-203. 1996
    ..In normal cells, the focal adhesion proteins tensin, p125(FAK), and paxillin constitutively associated with p130(CAS)...
  69. ncbi Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochem Biophys Res Commun 228:662-8. 1996
    Focal adhesion kinase (FAK) participates in signaling events induced by diverse stimuli including integrin engagement, oncogenic transformation and mitogenic neuropeptides...
  70. ncbi Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates
    K Tachibana
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:29083-90. 1997
    ..binding induces the tyrosine phosphorylation of various proteins including focal adhesion kinase (pp125(FAK)) and Crk-associated substrate (Cas)...
  71. ncbi Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions
    M Matsuya
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060, Japan
    J Biol Chem 273:1003-14. 1998
    ..These results indicate that Hic-5 is a paxillin-related component of focal adhesions and binds to CAKbeta, implying possible involvement of Hic-5 in the downstream signaling of CAKbeta...
  72. ncbi Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide
    F G Gervais
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec H9R 4P8, Canada
    J Biol Chem 273:17102-8. 1998
    ..fragments that are generated suppress phosphorylation of endogenous Fak and thus resemble a natural variant of Fak, FRNK, that inhibits Fak activity by preventing the localization of Fak to focal adhesions...
  73. pmc Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
    M L Borowsky
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 143:429-42. 1998
    ..We have identified a short region within talin's amino-terminal 435 amino acids capable of binding to layilin in vitro. This region overlaps a binding site for focal adhesion kinase...
  74. ncbi Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin
    S M Thomas
    Department of Medicine, Cancer Biology Program, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 112:181-90. 1999
    ..that Hic-5 is localized to focal adhesion in REF52 cells and can interact with the focal adhesion proteins, Fak, Frnk, and vinculin...
  75. ncbi Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
    K M Eisenmann
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nat Cell Biol 1:507-13. 1999
    ..Our findings indicate that MCSP may modify tumour growth or invasion by a unique signal-transduction pathway that links Cdc42 activation to downstream tyrosine phosphorylation and subsequent cytoskeletal reorganization...
  76. ncbi FAK integrates growth-factor and integrin signals to promote cell migration
    D J Sieg
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Cell Biol 2:249-56. 2000
    Here we show that cells lacking focal adhesion kinase (FAK) are refractory to motility signals from platelet-derived and epidermal growth factors (PDGF and EGF respectively), and that stable re-expression of FAK rescues these defects...
  77. pmc Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
    Z Lu
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 21:4016-31. 2001
    ..cells that overexpress EGFR, EGF treatment induced rapid tyrosine dephosphorylation of focal adhesion kinase (FAK) associated with downregulation of its kinase activity...
  78. ncbi Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2
    Ratna K Vadlamudi
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Cell Physiol 190:189-99. 2002
    ..differentially regulates the site-specific phosphorylation of the focal adhesion components focal adhesion kinase (FAK) and paxilin in a dose-dependent manner. HRG at suboptimal doses (0.01 and 0...
  79. ncbi The focal adhesion kinase--a regulator of cell migration and invasion
    Christof R Hauck
    Research Center for Infectious Diseases, Wurzburg, Germany
    IUBMB Life 53:115-9. 2002
    ..In this review, we summarize recent reports that connect the focal adhesion kinase (FAK) to cell migration and invasion...
  80. ncbi Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth
    Mossaad Abdel-Ghany
    Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    J Biol Chem 277:34391-400. 2002
    ..of Met, beta(4) integrin-mCLCA1-ligation leads to complexing with and activation of focal adhesion kinase (FAK) and downstream signaling to extracellular signal-regulated kinase (ERK)...
  81. ncbi Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells
    Vita Golubovskaya
    Lineberger Comprehensive Cancer Center, School of Medicine, and the Department Surgery, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:38978-87. 2002
    The focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) are protein-tyrosine kinases that are overexpressed and activated in human breast cancer...
  82. ncbi Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins
    Taroh H Satoh
    School of Natural and Health Sciences, Barry University, 11300 N E Second Ave, Miami Shores, FL 33161, USA
    Biocell 27:47-55. 2003
    ..Because p125 focal adhesion kinase (FAK) is a transducer in the beta 1-integrin signaling pathway, it is essential to cell adhesion and it is overexpressed ..
  83. ncbi FAK regulates biological processes important for the pathogenesis of cancer
    Veronica Gabarra-Niecko
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cancer Metastasis Rev 22:359-74. 2003
    ..initial discovery as a substrate and binding partner for the Src oncogene, a role for the focal adhesion kinase (FAK) in cancer has been speculated...
  84. ncbi Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites
    Vita Golubovskaya
    Department of Surgery, School of Medicine, University of Florida, Gainesville, FL 32610, USA
    Biochim Biophys Acta 1678:111-25. 2004
    Focal adhesion kinase (FAK) gene encodes focal adhesion kinase that localizes at contact points of cells with extracellular matrix...
  85. ncbi Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities
    Fabrice Le Boeuf
    Le Centre de Recherche en Cancérologie de l Université Laval, L Hôtel Dieu de Québec, Quebec G1R 2J6, Canada
    J Biol Chem 279:39175-85. 2004
    ..cells to vascular endothelial growth factor (VEGF) induced tyrosine phosphorylation of focal adhesion kinase (FAK) on site Tyr(407), an effect that required the association of VEGF receptor 2 (VEGFR2) with HSP90...
  86. ncbi Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs
    Edward Kyu Ho Han
    Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Division, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Anticancer Res 24:3899-905. 2004
    The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to the points of cell contact with the extracellular matrix, called focal adhesions...
  87. ncbi Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
    Ellen J Ezratty
    Department of Anatomy and Cell Biology, Columbia University, 630 West 168th Street, BB 1217, New York, NY 10032, USA
    Nat Cell Biol 7:581-90. 2005
    ..adhesions, and that this disassembly occurs independently of Rho and Rac, but depends on focal adhesion kinase (FAK) and dynamin. During disassembly, dynamin interacts with FAK and colocalizes with focal adhesions...
  88. ncbi JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration
    Takahisa Takino
    Department of Molecular Virology, Cancer Research Institute, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    J Biol Chem 280:37772-81. 2005
    ..for the mitogen-activated protein kinase (MAPK) cascades, and it also forms a complex with focal adhesion kinase (FAK)...
  89. ncbi Dual function of focal adhesion kinase in regulating integrin-induced MMP-2 and MMP-9 release by human T lymphoid cells
    Marta Segarra
    Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    FASEB J 19:1875-7. 2005
  90. ncbi Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability
    Michael Holinstat
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 281:2296-305. 2006
    ..Inhibition of FAK by adenoviral expression of FRNK (a dominant negative FAK construct) in monolayers prevented p190RhoGAP phosphorylation, increased RhoA activity, ..
  91. ncbi Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells
    Christopher A Garces
    Department of Surgery, Biochemistry, and Molecular Biology, University of Florida, PO Box 100286, 1600 Southwest Archer Road, Gainesville, FL 32610, USA
    Cancer Res 66:1446-54. 2006
    Focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) are protein tyrosine kinases that are overexpressed in human cancer and play an important role in survival signaling...
  92. ncbi Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome
    Boris Gabriel
    Departments of Obstetrics and Gynecology and Pathology, Freiburg University Medical Center, Freiburg, Germany
    Clin Cancer Res 12:2476-83. 2006
    The pp125 focal adhesion kinase (FAK) plays a pivotal role in tumor cell signaling. FAK expression has been linked to tumor cell invasion and metastasis, but data on cervical cancer are inconclusive...
  93. ncbi FAK phosphorylation at Ser-843 inhibits Tyr-397 phosphorylation, cell spreading and migration
    Rodrigo Jacamo
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Cell Physiol 210:436-44. 2007
    Multiple stimuli promote the tyrosine phosphorylation and activation of focal adhesion kinase (FAK), which ultimately facilitates migration...
  94. pmc Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells
    Xiaohua Jiang
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095 178622, USA
    Cell Signal 19:1000-10. 2007
    A rapid increase in the tyrosine phosphorylation of the non-receptor tyrosine kinase FAK is a prominent early event in fibroblasts stimulated by a variety of signaling molecules...
  95. ncbi N-MYC regulates focal adhesion kinase expression in human neuroblastoma
    Elizabeth A Beierle
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 282:12503-16. 2007
    ..Focal adhesion kinase (FAK) is a survival factor that has been shown to be overexpressed in many types of human cancers...
  96. doi Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses
    Elizabeth A Beierle
    Department of Surgery, University of Florida, College of Medicine, PO Box 100286, J Hillis Miller Health Science Center, Gainesville, FL 32610 0286, USA
    Clin Cancer Res 14:3299-305. 2008
    The focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase important in signaling between cells and their extracellular matrix...
  97. pmc Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK)
    Keefe T Chan
    Department of Molecular and Cellular Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 285:11418-26. 2010
    ..regions after Ser-745, resulting in a C-terminal fragment similar in size to the FAK-related non-kinase (FRNK)...
  98. doi Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase
    Xiao Dong Fu
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Endocr Relat Cancer 17:431-43. 2010
    ..In T47-D breast cancer cells, progesterone rapidly enhances FA kinase (FAK) phosphorylation at Tyr(397) in a time- and concentration-dependent manner...
  99. doi Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival
    Lianshu Ding
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Transl Res 156:45-52. 2010
    Human glioma is a malignancy that has no effective systemic therapy. Focal adhesion kinase (FAK) is overexpressed in various invasive and metastatic tumor cells...
  100. pmc Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy
    Fadila Guessous
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cancer Ther 11:288-97. 2012
    ..The nonreceptor tyrosine kinases focal adhesion kinase (FAK) and Pyk2 are key players in the progression of different cancers...
  101. pmc Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
    M D Schaller
    Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908
    Mol Cell Biol 14:1680-8. 1994
    ..The integrin-linked focal adhesion kinase, pp125FAK, exhibits extracellular matrix-dependent phosphorylation on tyrosine and physically associates with two ..

Research Grants73

  1. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    Genetic Analysis of FAK Activity Binding interactions between extracellular matrix proteins such as fibronectin and integrins play fundamental roles during development by controlling cell adhesion, motility, and survival...
  2. David D Schlaepfer; Fiscal Year: 2016
    ..are localized to adhesions and this proposal will focus on the molecular interactions of focal adhesion kinase (FAK) and a guanine nucleotide exchange factor (GEF) for Rho-family GTPases termed ARHGEF28 (alternative names are ..
  3. Role of p190RhoGEF (Rgnef) in cell motility and tumor progression
    Nichol L G Miller; Fiscal Year: 2013
    ..A novel feature of Rgnef is that it contains a binding site for the integrin-activated focal adhesion kinase (FAK). What remains unknown is how Rgnef is regulated within cells...
  4. Jun Lin Guan; Fiscal Year: 2016
    ..Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays a major role in mediating signal transduction by integrins as well as ..
  5. The role of Vimentin in cell adhesion and lung cancer metastasis
    LAUREN SMITH HAVEL; Fiscal Year: 2013
    ..Focal adhesion kinase (FAK), which is activated by phosphorylation at Y397, also localizes to the focal adhesions...
  6. Timothy A Springer; Fiscal Year: 2015
    ..Adhesion molecules including integrins, and signaling molecules including focal adhesion kinase (FAK) and immune receptors, are key in all of these processes, and are important targets of drugs currently approved and ..
  7. Directed growth cone migration by calcium signals
    James Q Zheng; Fiscal Year: 2011
    ..mechanisms that sense various Ca2+ signals to control growth cone turning, (3) to test the hypothesis that FAK/Src links Ca2+ signaling to tyrosine phosphorylation in growth cone guidance...
  8. Frank A Anania; Fiscal Year: 2016
    ..is that adiponectin promotes the resolution of hepatic fibrosis by inhibiting activation of focal adhesion kinase (FAK), preventing formation of focal adhesions (FAs), which results in the suppression of key fibrogenic properties of ..
  9. Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte Death
    Abdelkarim Sabri; Fiscal Year: 2012
    ..CG induced Cbl activation in neonatal rat cardiomyocytes in-vitro that was associated with its interaction with FAK. We also found that FAK becomes heavily serine phosphorylated prior to its inactivation and degradation in response ..
  10. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    ..and inhibit NFkB migration to the nucleus following exposure of endothelial cells to TNFa by an NO-independent Fak-mediated mechanism...
  11. Shuta Ishibe; Fiscal Year: 2016
    ..The goal of this research project is to define the role of focal adhesion protein, Focal Adhesion Kinase (FAK), a critical regulator of cell movement, in podocyte regulation following injury...
  12. Actions of the Sodium-Hydrogen Exchanger Subtype, NHE1
    Diane L Barber; Fiscal Year: 2012
    ..We will ask how autophosphorylation of FAK is NHE1- dependent by testing the prediction that protonation of histidine residues in the FERM domain of FAK ..
  13. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..renewal: adiponectin promotes the resolution of hepatic fibrosis by inhibiting activation of focal adhesion kinase (FAK), preventing formation of focal adhesions (FA) which results in the suppression of key fibrogenic properties of the ..
  14. Metastatic protein network in BRAFV600E positive human thyroid cancers
    Carmelo Nucera; Fiscal Year: 2013
    ..e. focal adhesion kinase (FAK)) and the transcription factor (TF) HMGB1, which has been implicated in melanoma progression and metastasis...
  15. Radhakrishna Rao; Fiscal Year: 2016
    ..on threonine residues;these processes involve the intracellular signaling molecules such as c-Src, FAK, PI3K, PP2A, PKC7, PKC6 and PP1...
  16. Stimuli promoting the survival of spiral ganglion neurons
    Steven H Green; Fiscal Year: 2011
    ..We further show that CaMKII does so by recruiting nonreceptor protein-tyrosine kinases, FAK and Pyk2, and protein kinase B (PKB)...
  17. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2009
    ..on threonine residues;these processes involve the intracellular signaling molecules such as c-Src, FAK, PI3K, PP2A, PKCh, PKCz and PP1...
  18. Novel Approaches in Treatment of Vascular Injury Following Balloon Angioplasty
    YEVGENIYA EMRE KOSHMAN; Fiscal Year: 2013
    ..The overall hypothesis of my NRSA application is that upregulation of FRNK, a naturally occurring inhibitor of FAK and PYK2, during vascular remodeling reduces smooth muscle cell migration ..
  19. Role of Paxillin in Lung Cancer
    Ravi Salgia; Fiscal Year: 2012
    ..The mutations were localized in between the LD domains (important for binding other molecules such as FAK) and in the LIM domains (zinc finger domains important in actin binding)...
  20. Role of beta-1 containing integrins in JNK activation in lung mechanical stretch
    LINDY SARA KLAFF; Fiscal Year: 2010
    ..clustering at focal adhesion complexes and signaling through multiple proteins including focal adhesion kinase (FAK)...
  21. CB1 Receptor-Mediated Tyrosine Phosphorylation of FAK and ERK in Neurons
    George D Dalton; Fiscal Year: 2012
    ..established that cannabinoid agonists activate CB1Rs to induce the Tyr phosphorylation of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) in N18TG2 (N18) neuroblastoma cells...
  22. Alexander Ungewickell; Fiscal Year: 2014
    ..of the [unreadable]1 and [unreadable]4 integrin subunits as well as the integrin associated focal adhesion kinase (FAK) in mediating early epidermal tumor progression...
  23. Mechanisms of Environmental Stress Affecting Corneal Epithelial Wound Healing
    Luo Lu; Fiscal Year: 2011
    ..K+ ions causes cell volume shrinkage;and 3) cell shrinkages induce activations of scaffolding tyrosine kinases (FAK/Src) and MEKK1/4 in the JNK signaling pathway...
  24. The role of focal adhesion kinase in CNS myelination
    Audrey D Lafrenaye; Fiscal Year: 2010
    ..The protein focal adhesion kinase (FAK) plays a central role in plasma membrane-ECM interactions...
  25. Jie J Zheng; Fiscal Year: 2015
    ..One major group of LD binding partners comprises the focal adhesion targeting (FAT) domain of FAK and the FAT-like domains of other FA proteins...
  26. Stephen Leonard; Fiscal Year: 2014
    ..Finally, the effects of stabilizing distinct SFK ATP-binding site conformations on Src/FAK complex formation, phosphorylation of complex substrates, and rescue of cell motility will be investigated in SFK-..
  27. Anna Huttenlocher; Fiscal Year: 2016
    ..We now propose to investigate how calpains and associated proteins including FAK and PCH family members modulate the temporal and spatial activation of Src kinases and specific substrate ..
  28. Christopher S Chen; Fiscal Year: 2016
    ..of this novel proliferative pathway in vivo, Specific Aim 3 will examine the interplay between ECM stiffening, FAK and N-cadherin during VSMC cycling in vivo...
  29. Joshua A Weiner; Fiscal Year: 2016
    ..We hypothesize that this disrupts the gamma -Pcdhs'ability to inhibit PKC signaling via inhibition of FAK, providing a signaling feedback mechanism...
  30. Jiwang Zhang; Fiscal Year: 2014
    ..Pten, a tumor suppressor, has both lipid and protein phosphatase activities that inhibit PI3K/Akt and Fak-MAPK signaling respectively...
  31. Smooth muscle adhesion and plasticity in coronary and outflow tract development
    Joan M Taylor; Fiscal Year: 2013
    ..We have previously demonstrated that an endogenous inhibitor of FAK, termed FRNK, is selectively expressed in SMC with particularly high levels observed in conduit blood vessels and that FRNK ..
  32. Emp2: Potential Control Of Pathology In Retinal Pigment Epithelium
    Lynn Gordon; Fiscal Year: 2009
    ..the prediction that dose synergy with reduced toxicity could be achieved through combined targeting of EMP2 and the FAK/Src pathway...
  33. Jun Lin Guan; Fiscal Year: 2014
    ..The previous funding period focused on the role of focal adhesion kinase (FAK) and several other proteins in the regulation of cell migration and breast cancer development and metastasis...
  34. The role of CTGF in bone cell development and function
    Steven N Popoff; Fiscal Year: 2012
    ..integrin, resulting in the formation of focal adhesions, cytoskeletal reorganization and the activation of FAK and Erk...
  35. Patricia J Keely; Fiscal Year: 2014
    ..dense ECM enhances the formation of matrix adhesions that result in activation of signaling pathways linked to FAK, and that FAK is a central mediator by which matrix density regulates gene expression to promote proliferation and ..
  36. The Role of Osteoactivin in Osteoblast Development and Function
    Fayez F Safadi; Fiscal Year: 2013
    ..integrin, resulting in the formation of focal adhesions, cytoskeletal reorganization and the activation of FAK. Studies proposed in aim 3 will test the hypothesis that OA acts as a matricellular protein that binds to specific ..
  37. Jun Lin Guan; Fiscal Year: 2016
    ..In the previous funding period, we focused on the role and mechanisms of focal adhesion kinase (FAK) signaling in ECs during embryonic angiogenesis and FAK- family interacting protein of 200 kDa (FIP200) in cardiac ..
  38. FAK in Stress-activated Signaling and Tumor Invasion
    J Lunn; Fiscal Year: 2009
    ..tumor invasion is multifaceted, I have chosen to focus my studies on a central signal-integrating molecule, FAK, focal adhesion kinase in this process. This proposal is designed in three phases: 1...
  39. Michael Birrer; Fiscal Year: 2014
    ..Furthermore, exogenous MAGP-2 was shown to significantly induce Ca2+ oscillation and FAK phosphorylation in HUVECs and an ovarian cancer cell line OVCA429...
  40. Lawrence B Holzman; Fiscal Year: 2016
    ..In mice, podocyte-specific deletion of Crk1/2 blocks injury-induced foot process effacement. Phosphorylation of FAK and Cas are induced in podocytes of patients with human minimal change disease and in membranous nephropathy ..
  41. Rita Nahta; Fiscal Year: 2016
    ..the role of the IGF-IR/HER2/HER3 receptor complex in acquired Herceptin resistance, and (3) if IGF-IR, HER3, and FAK are in vivo targets for improving response to Herceptin...
  42. The kinase toolbox: Mapping the spatial and temporal regulation of cell signaling
    Sivaraj Sivaramakrishnan; Fiscal Year: 2013
    ..We have developed and tested kinase toolboxes for focal adhesion kinase (FAK) and protein kinase C (PKC)...
  43. Imagining Human Cancer Progression in a Novel Zebrafish Model
    Richard L Klemke; Fiscal Year: 2012
    ..cell[unreadable]invasion[unreadable]through[unreadable]activation[unreadable]of[unreadable]the[unreadable]FAK[unreadable]Src[unreadable]CAS[unreadable]Crk[unreadable]Rac[unreadable]signaling[unreadable]module,[unreadable]..
  44. How Does a4B1 Integrin Regulate Cell Migration?
    Joy Yang; Fiscal Year: 2010
    ..focal adhesion turnover;(c) regulating MLC phosphorylation and filament assembly;and (d) regulating RhoAand FAK-mediated pathways...
  45. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..The compliance-regulated signaling pathway involves FAK, but is distinguishable from the signaling pathways that we and others have previously implicated in integrin-..
  46. David D Schlaepfer; Fiscal Year: 2016
    ..provided by applicant): The overall goal of this proposal is to understand the role of focal adhesion kinase (FAK) in promoting tumor progression...
  47. Molecular Biomarkers of Small Cell Lung Cancer Behaviour
    Pierre P Massion; Fiscal Year: 2013
    ..We will confirm FAK amplification in SCLC, determine the expression level in tissue microarrays, and determine a role of FAK in SCLC by ..
  48. Biological and Therapeutic Significance of TG2 in Pancreatic Cancer
    Kapil Mehta; Fiscal Year: 2010
    ..apoptosis and invasion;b) over expression of TG2 promotes constitutive activation of the focal adhesion kinase (FAK), Akt and NF-:B;c) inhibition of TG2 by small interfering RNA (siRNA) inhibited invasion and induced autophagic ..
  49. Mechanotransduction in Acute Lung Injury
    Christopher M Waters; Fiscal Year: 2012
    ..mechanical stretch causes loss of cell adhesion and inhibition of repair mechanisms through focal adhesion kinase (FAK) signaling...
  50. Robert S Krauss; Fiscal Year: 2015
    ..myofibers are controlled at the post-translational level by signal transduction pathways such as p38 MAP kinase and FAK. However, how the signaling pathways that stimulate the differentiation program are initiated and regulated is ..
  51. ENGINEERING INTEGRIN--MEDIATED CELL MIGRATION
    Douglas Lauffenburger; Fiscal Year: 2002
    ..focus of the next grant period would be on testing how this relationship is governed by integrin signaling targets (FAK and MAPK), regulators (calpain) and cytoskeletal linkage (talin), and how cell migration behavior and population ..
  52. Heather R Burkin; Fiscal Year: 2015
    ..pathway are just beginning to be elucidated, however recent data have shown that Focal Adhesion Kinase (FAK) is activated in term human myometrial tissue, a strong indicator of integrin engagement (Li et al., 2009)...
  53. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..pathway are just beginning to be elucidated, however recent data have shown that Focal Adhesion Kinase (FAK) is activated in term human myometrial tissue, a strong indicator of integrin engagement (Li et al., 2009)...
  54. The Role of HEF1 in Ovarian Cancer Development, Progression, and Metastasis
    Denise C Connolly; Fiscal Year: 2013
    ..Among these are focal adhesion kinase (FAK), Src and signal transducer and activator of transcription 3 (STAT3)...
  55. Cytoskeletal regulation of T cell-APC interactions
    Anna Huttenlocher; Fiscal Year: 2012
    ..of focal adhesion turnover, talin, phosphatidylinositide phosphate kinase PIPKI390 and focal adhesion kinase (FAK) differentially regulate the polarization of the integrin LFA-1 and the dynamic assembly and disassembly of T cell- ..
  56. HEF1 Coordination of Cell Cycle, Migration, and Invasion in Cancer
    Erica A Golemis; Fiscal Year: 2013
    ..Our work in past cycles of RO1 CA63366 defined interactions of HEF1 with the oncoproteins Src and FAK as critical for HEF1 action in promoting cell migration and invasion...
  57. Modulation of Glioma Growth and Invasion by HCMV Glycoprotein B
    Liliana Soroceanu; Fiscal Year: 2010
    ..in GBM cells can induce cellular tyrosine kinase signaling pathways critical for tumor growth (Akt, PLC3, FAK), inhibit p53 and Rb tumor suppressor activity, alter cell cycle checkpoint controls, and promote cell ..
  58. William G Cance; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Focal Adhesion Kinase (FAK) is a 125kDa protein tyrosine kinase that is overexpressed in a number of different types of solid tumors and has emerged as a major cancer therapeutic target...
  59. TARGETS OF AMINO ACID RESTRICTION IN PROSTATE CANCER
    Gary G Meadows; Fiscal Year: 2009
    ..We hypothesize that specific amino acid-regulated invasion is dependent on the inhibition of FAK and its binding partners...
  60. Lucia R Languino; Fiscal Year: 2015
    ..receptor-1 (IGF-IR), modulating the activation of cytoplasmic kinases, including AKT and Focal Adhesion Kinase (FAK), and promoting tumor cell survival by counteracting apoptosis...
  61. The role of c-Met expression in melanoma growth and migration
    AMBER LEIGH SHADA; Fiscal Year: 2010
    ..via deactivation of the MAPKinase and mTOR pathways, and will lead to reduced migration via deactivation of the Src/FAK pathway...
  62. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..to adult dog cardiomyocytes (plated on laminin) resulted in direct cleavage of laminin, focal adhesion kinase (FAK) dephopsphorylation, MMP release and myosin degradation...
  63. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ..phosphorylation of multiple proteins, including the non-receptor tyrosine kinase p125 focal adhesion kinase (FAK) and the adaptor proteins p130 Crk-associated substrate (CAS) and paxillin, which are implicated in cell migration ..
  64. ROLE OF SRC AND FAK IN STORE-OPERATED CA 2+ ENTRY
    MITCHEL VILLEREAL; Fiscal Year: 2003
    ..grant period, a molecular approach provided evidence for the involvement of c-src and focal adhesion kinase (FAK) in the regulation of SOCs...
  65. PTP--PEST AND FOCAL ADHESION SIGNALING
    MICHAEL SCHALLER; Fiscal Year: 2002
    ..kinases (PTKs) that are regulated by cell adhesion have been identified and include the focal adhesion kinase (FAK) and Src...
  66. FAK and Breast Cancer
    MICHAEL SCHALLER; Fiscal Year: 2005
    ..The dominant negative FAK variant, FRNK, has been expressed in the T47D breast cancer cell line...
  67. STRUCTURAL INVESTIGATION OF FOCAL ADHESION MOLECULES
    Jie Zheng; Fiscal Year: 2007
    ..A key player in integrin signaling is focal adhesion kinase (FAK). Activation and localization of FAK to focal adhesions results from the binding of integrins to ECM proteins...
  68. INTEGRIN SIGNALLING IN VASCULAR ENDOTHELIUM
    Lewis Romer; Fiscal Year: 2000
    ..Our central hypothesis is that FAK (ppl25FAK, focal adhesion kinase) is essential to the organization of the cytoskeleton and the facilitation of ..
  69. DEVELOPMENTAL ALTERATIONS IN CARDIAC PROTEIN TURNOVER
    Allen Samarel; Fiscal Year: 2003
    ..In addition, the nonreceptor protein tyrosine kinase pp125fak (FAK) which localizes to cardiomyocyte focal adhesions, is activated in response to neurohormonal and mechanical ..
  70. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2007
    ..sucrose enhances lung microvascular barrier properties by activating the protein, focal adhesion kinase (FAK), thereby blocking pulmonary edema in acute lung[unreadable] injury (ALI)...
  71. MITOGENIC SIGNALING BY ENDOTHELIN PEPTIDES
    Michael Simonson; Fiscal Year: 2002
    ..Aim 2 will determine whether FAK and/or Pyk2 may be upstream activators of c-Src in the ET-1 ras-MAPkinase-mitogenic signal. 1...