factor I

Summary

Gene Symbol: factor I
Description: complement factor I
Alias: AHUS3, ARMD13, C3BINA, C3b-INA, KAF, complement factor I, C3B/C4B inactivator, C3b-inactivator, Konglutinogen-activating factor, complement component I, complement control protein factor I, complement factor I heavy chain, light chain of factor I
Species: human

Top Publications

  1. ncbi Evaluation of expressed emotion (EE) status in mood disorders in japan: inter-rater reliability and characteristics of EE
    Y Mino
    Department of Hygiene and Preventive Medicine, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Psychiatry Res 94:221-7. 2000
  2. ncbi Relationship between dental caries experience (DMFS) and dental fluorosis in 12-year-old Puerto Ricans
    A R Elías-Boneta
    Research Center, School of Dentistry, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
    Community Dent Health 23:244-50. 2006
  3. doi Cardiac output and blood volume parameters using femoral arterial thermodilution
    Jesús López-Herce
    Pediatric Intensive Care Unit, Gregorio Maranon General University Hospital, Madrid, Spain
    Pediatr Int 51:59-65. 2009
  4. doi Determining the optimal fluoride concentration in drinking water for fluoride endemic regions in South India
    Gopalan Viswanathan
    Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli 627012, Tamil Nadu, India
    Sci Total Environ 407:5298-307. 2009
  5. doi A novel mutation in the complement factor B gene (CFB) and atypical hemolytic uremic syndrome
    Hanan Tawadrous
    Division of Pediatric Nephrology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pediatr Nephrol 25:947-51. 2010
  6. ncbi Mapping of the human complement factor I gene to 4q25
    R Shiang
    Department of Pediatrics, University of Iowa, Iowa City 52242
    Genomics 4:82-6. 1989
  7. pmc Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones
    C F Catterall
    Biochem J 242:849-56. 1987
  8. ncbi Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4
    G Goldberger
    J Biol Chem 262:10065-71. 1987
  9. pmc The molecular basis of hereditary complement factor I deficiency
    T J Vyse
    Department of Medicine, RPMS, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 97:925-33. 1996
  10. pmc Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome
    V Fremeaux-Bacchi
    Service d Immunologie Biologique, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France
    J Med Genet 41:e84. 2004

Research Grants

  1. Contact Fluorescence Imaging
    Leslie Tung; Fiscal Year: 2006
  2. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
  3. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
  4. In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against Myc
    Igor Gonda; Fiscal Year: 2013
  5. Margaret A Pericak-Vance; Fiscal Year: 2014
  6. Planning for Long Term Care--Pilot Data Collection
    BURTON DUNLOP; Fiscal Year: 2001
  7. CHARACTERIZATION OF CELL RECEPTORS FOR IGE AND C3
    Daniel Conrad; Fiscal Year: 1980
  8. COMPUTER ASSISTED ALCOHOL INTERVENTION IN MEDICAL CARE
    JONATHON ROSEN; Fiscal Year: 2000
  9. EYE-COM 6/MSV CAMERA: A Drowsiness Detecting Biosensor
    WILLIAM TORCH; Fiscal Year: 2001
  10. Health Promotion for Women with Fibromyalgia
    Alexa Stuifbergen; Fiscal Year: 2006

Detail Information

Publications235 found, 100 shown here

  1. ncbi Evaluation of expressed emotion (EE) status in mood disorders in japan: inter-rater reliability and characteristics of EE
    Y Mino
    Department of Hygiene and Preventive Medicine, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Psychiatry Res 94:221-7. 2000
    ..Expressed emotion was more suppressed in families of patients with mood disorders than in those of patients with schizophrenia. Expressed emotion was also more reserved in the Japanese subjects than in their Western counterparts...
  2. ncbi Relationship between dental caries experience (DMFS) and dental fluorosis in 12-year-old Puerto Ricans
    A R Elías-Boneta
    Research Center, School of Dentistry, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico
    Community Dent Health 23:244-50. 2006
    ..Examine the relationship between (1) DMFS and community fluorosis index (CFI) scores, and (2) between individual DMFS and NIDR/Dean Index fluorosis scores...
  3. doi Cardiac output and blood volume parameters using femoral arterial thermodilution
    Jesús López-Herce
    Pediatric Intensive Care Unit, Gregorio Maranon General University Hospital, Madrid, Spain
    Pediatr Int 51:59-65. 2009
    ..The normal values in children have not been defined. The purpose of the present paper was therefore to evaluate cardiac output and parameters of blood volume using femoral arterial thermodilution in critically ill children...
  4. doi Determining the optimal fluoride concentration in drinking water for fluoride endemic regions in South India
    Gopalan Viswanathan
    Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli 627012, Tamil Nadu, India
    Sci Total Environ 407:5298-307. 2009
    ..From the result, the people in fluoride endemic areas in South India are advised to consume drinking water with fluoride level within the limit of 0.5 to 0.65 mg/l to avoid further fluorosis risk...
  5. doi A novel mutation in the complement factor B gene (CFB) and atypical hemolytic uremic syndrome
    Hanan Tawadrous
    Division of Pediatric Nephrology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pediatr Nephrol 25:947-51. 2010
    ..in genes encoding regulators of complement-complement factor H (CFH), membrane cofactor protein or complement factor I (CFI)-or activators of complement-complement factor B (CFB) or C3...
  6. ncbi Mapping of the human complement factor I gene to 4q25
    R Shiang
    Department of Pediatrics, University of Iowa, Iowa City 52242
    Genomics 4:82-6. 1989
    A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25...
  7. pmc Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones
    C F Catterall
    Biochem J 242:849-56. 1987
    A cDNA clone of the mRNA coding for the human complement system control protein Factor I has been isolated...
  8. ncbi Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4
    G Goldberger
    J Biol Chem 262:10065-71. 1987
    ..conversion of pro-I and activation of other serine proteinase zymogens; and 3) indicates that the light chain of factor I resembles most closely the active subunit of tissue plasminogen activator among all serine proteinases ..
  9. pmc The molecular basis of hereditary complement factor I deficiency
    T J Vyse
    Department of Medicine, RPMS, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 97:925-33. 1996
    The molecular basis of hereditary complement factor I deficiency is described in two pedigrees...
  10. pmc Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome
    V Fremeaux-Bacchi
    Service d Immunologie Biologique, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France
    J Med Genet 41:e84. 2004
  11. pmc Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome
    Jessica Caprioli
    Mario Negri Institute for Pharmacologic Research, Clinical Research Center for Rare Diseases, Aldo e Cele Daccò, Bergamo, Italy
    Blood 108:1267-79. 2006
    ..We undertook genetic analysis on membrane cofactor protein (MCP), complement factor H (CFH), and factor I (IF) in 156 patients with non-Stx-HUS...
  12. pmc Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome
    Aude Servais
    Department of Nephrology, Necker Hospital, Paris, France
    J Med Genet 44:193-9. 2007
    Abnormal control of the complement alternative pathway (CAP) (factor H, factor I and membrane cofactor protein (MCP) deficiencies) is a well established risk factor for the occurrence of haemolytic uraemic syndrome (HUS)...
  13. ncbi Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides
    Stefanos A Tsiftsoglou
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, UK
    Biochim Biophys Acta 1764:1757-66. 2006
    b>Factor I (fI) is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases...
  14. ncbi A missense mutation in factor I (IF) predisposes to atypical haemolytic uraemic syndrome
    Joyce Geelen
    Department of Paediatric Nephrology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Pediatr Nephrol 22:371-5. 2007
    ..In this paper, a patient with a heterozygous missense mutation in factor I (IF) is described...
  15. ncbi Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome
    David Kavanagh
    Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Immunol 45:95-105. 2008
    Recent studies have identified mutations in the complement regulatory gene factor I (CFI) that predispose to atypical hemolytic uremic syndrome (aHUS)...
  16. ncbi Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome
    Anne Laure Sellier-Leclerc
    Service de Nephrologie, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, 48 Boulevard Serurier, 75 019 Paris, France
    J Am Soc Nephrol 18:2392-400. 2007
    Mutations in factor H (CFH), factor I (IF), and membrane cofactor protein (MCP) genes have been described as risk factors for atypical hemolytic uremic syndrome (aHUS)...
  17. doi Molecular characterization of Complement Factor I deficiency in two Spanish families
    Isabel María Ponce-Castro
    Unidad de Inmunologia, Hospital Universitario La Paz, Paseo de la Castellana 261, Madrid, Spain
    Mol Immunol 45:2764-71. 2008
    b>Complement Factor I (CFI) is a regulator of the classical and alternative pathways. CFI has enzymatic activity and is able to cleave C3b and C4b. Homozygous Factor I deficiency is associated with infectious and/or autoimmune diseases...
  18. doi Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b
    Pamela S Hair
    Department of Pediatrics, George L Wright, Jr, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Infect Dis 198:125-33. 2008
    ..component deposited on the organism's surface, C3b, can be cleaved by the host complement control protein, factor I, resulting in diminished phagocytosis of S. aureus...
  19. ncbi Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen
    Jiying Wang
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 181:712-20. 2008
    ..Our results showed that Abeta binds to complement factor I which inhibits the ability of factor I to cleave C3b to inactivated iC3b...
  20. pmc Variation near complement factor I is associated with risk of advanced AMD
    Jesen A Fagerness
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Eur J Hum Genet 17:100-4. 2009
    ..This analysis identified a single nucleotide polymorphism just 3' of complement factor I on chromosome 4 showing significant association (P<10(-7))...
  21. doi Genetic, molecular and functional analyses of complement factor I deficiency
    Sara C Nilsson
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Eur J Immunol 39:310-23. 2009
    Complete deficiency of complement inhibitor factor I (FI) results in secondary complement deficiency due to uncontrolled spontaneous alternative pathway activation leading to susceptibility to infections...
  22. pmc Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
    Iain Moore
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Blood 115:379-87. 2010
    ..In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3. The latter observation emphasizes that multiple concurrent factors may be necessary in individual patients for disease manifestation...
  23. doi Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome
    Frank Bienaime
    Cordeliers Research Center, INSERM UMRS 872, Paris, France
    Kidney Int 77:339-49. 2010
    ..b>Factor I is a circulating serine protease that inhibits complement by degrading C3b and up to now only a few mutations in ..
  24. pmc Analysis of binding sites on complement factor I that are required for its activity
    Sara C Nilsson
    Department of Laboratory Medicine, Medical Protein Chemistry, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    J Biol Chem 285:6235-45. 2010
    The central complement inhibitor factor I (FI) degrades activated complement factors C4b and C3b in the presence of cofactors such as C4b-binding protein, factor H, complement receptor 1, and membrane cofactor protein...
  25. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies...
  26. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  27. pmc Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, 800 WashingtonStreet, No 450, Boston, MA 02111, USA
    Hum Mol Genet 20:3699-709. 2011
    ..The novel variants identified in this study suggest that angiogenesis (VEGFA) and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced AMD...
  28. pmc Structural basis for complement factor I control and its disease-associated sequence polymorphisms
    Pietro Roversi
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:12839-44. 2011
    ..We have determined the crystal structure of the complement regulatory enzyme human factor I (fI)...
  29. pmc Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?
    David Kavanagh
    Institutes of Cellular and Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin J Am Soc Nephrol 7:417-26. 2012
    ..In addition, factor H autoantibodies have been reported in ∼10% of patients with atypical hemolytic uremic syndrome. This study searched for the presence of factor I autoantibodies in atypical hemolytic uremic syndrome.
  30. doi A functional variant in the CFI gene confers a high risk of age-related macular degeneration
    Johannes P H van de Ven
    Department of Ophthalmology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Genet 45:813-7. 2013
    ..Taken together, these findings demonstrate that rare, highly penetrant mutations contribute to the genetic burden of AMD...
  31. pmc Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration
    Johanna M Seddon
    1 Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, Massachusetts, USA 2 Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, USA 3 Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
    Nat Genet 45:1366-70. 2013
    ..These results implicate loss of C3 protein regulation and excessive alternative complement activation in AMD pathogenesis, thus informing both the direction of effect and mechanistic underpinnings of this disorder...
  32. doi Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome
    Tara K Maga
    Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 31:E1445-60. 2010
    ..in a number of complement genes including complement factor H (CFH), complement factor H-related 5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD)...
  33. pmc aHUS caused by complement dysregulation: new therapies on the horizon
    Aoife M Waters
    Department of Nephrology, Great Ormond Street Hospital, London, WC1N 3JH, UK
    Pediatr Nephrol 26:41-57. 2011
    ..Mutations have been identified in genes encoding both complement regulators [complement factor H (CFH), complement factor I (CFI), complement factor H-related proteins (CFHR), and membrane cofactor protein (MCP)], as well as ..
  34. ncbi Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome
    G Monteferrante
    Transplant Research Center Chiara Cucchi de Alessandri e Gilberto Crespi, Mario Negri Institute for Pharmacological Research, Villa Camozzi, Via Privata Camozzi 3, 24020 Ranica, Bergamo, Italy
    Mol Immunol 44:1704-8. 2007
    ..Mutations in genes encoding other complement regulatory proteins, membrane cofactor protein (CD46) and complement factor I (CFI), were also involved in the pathogenesis of the disease...
  35. doi Complement factor H deficiency and posttransplantation glomerulonephritis with isolated C3 deposits
    Olivia Boyer
    Pediatric Nephrology, Hopital Necker Enfants Malades, Universite Paris Descartes, Paris, France
    Am J Kidney Dis 51:671-7. 2008
    ..Patient 1 had combined CFH and complement factor I (CFI) heterozygous mutations and a membrane cofactor protein (gene symbol, CD46) gene polymorphism...
  36. ncbi Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome
    Maria Goretti Polito
    Universidade Federal de Sao Paulo, Brazil
    J Bras Nefrol 32:303-15. 2010
    ..regulatory proteins, which normally protect host cells from complement activation: complement factor H (CFH), factor I (CFI) and membrane cofactor protein (MCP or CD46), or have 'gain-of-function' mutations in the genes encoding the ..
  37. ncbi Serum complement factor I decreases Staphylococcus aureus phagocytosis
    Kenji M Cunnion
    Department of Pediatrics, Eastern Virginia Medical School and Children s Hospital of The King s Daughters, Norfolk, USA
    J Lab Clin Med 146:279-86. 2005
    ..aureus. We have shown that complement control protein factor I mediates cleavage of the complement opsonin C3b bound to the S. aureus surface...
  38. ncbi Characterization of Xenopus laevis complement factor I structure--conservation of modular structure except for an unusual insert not present in human factor I
    L M Kunnath-Muglia
    Department of Hematology Oncology, Children s Hospital, Boston, MA 02115
    Mol Immunol 30:1249-56. 1993
    b>Factor I (C3b/C4b inactivator) is a regulatory protein of the classical and alternative complement pathways. In this paper, we report the sequence of Xenopus factor I cDNA and the deduced protein structure...
  39. doi Atypical hemolytic uremic syndrome: update on the complement system and what is new
    Patricia Hirt-Minkowski
    Division of Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Nephron Clin Pract 114:c219-35. 2010
    ..regulatory proteins, which normally protect host cells from complement activation: complement factor H (CFH), factor I (CFI) and membrane cofactor protein (MCP or CD46), or have 'gain-of-function' mutations in the genes encoding the ..
  40. doi Molecular characterization of two novel cases of complete complement inhibitor Factor I deficiency
    Izabela M Nita
    Department of Laboratory Medicine, Section of Medical Protein Chemistry, Lund University, Sweden
    Mol Immunol 48:1068-72. 2011
    b>Factor I (FI) is the major complement inhibitor that degrades activated complement components C3b and C4b in the presence of specific cofactors...
  41. doi [Open or closed minor amputation for diabetic gangrene?]
    S Ozdemir
    Klinik fur Endokrinologie, Diabetologie und Rheumatologie der Heinrich Heine Universität Düsseldorf
    Vasa 38:54-61. 2009
    ..Amputation below the ankle at the diabetic foot is rarely successful, if carried out as closed amputation (with primary wound closure)...
  42. doi The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome
    M A Dragon-Durey
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service d Immunologie Biologique, Paris, France
    J Med Genet 46:447-50. 2009
    ..We tested the CFHR1 deletion for association with aHUS in a population of French aHUS cases and controls. Furthermore, we examined the effect of the deletion in the context of known aHUS risk factors...
  43. doi Successful renal transplantation in a patient with atypical hemolytic uremic syndrome carrying mutations in both factor I and MCP
    J M Cruzado
    Servei de Nefrologia, Hospital Universitari de Bellvitge, IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Am J Transplant 9:1477-83. 2009
    ..hemolytic uremic syndrome (aHUS) carrying mutations in the soluble complement regulators factor H (CFH) or factor I (CFI) is associated with elevated risk of disease recurrence and almost certain graft loss...
  44. ncbi Dental caries experience in the Chiangmai/Lamphun provinces of Thailand
    Y Songpaisan
    Intercountry Centre for Oral Health, Chiangmai, Thailand
    Community Dent Oral Epidemiol 17:131-5. 1989
    ....
  45. pmc Mpe1, a zinc knuckle protein, is an essential component of yeast cleavage and polyadenylation factor required for the cleavage and polyadenylation of mRNA
    L T Vo
    Centre de Genetique Moleculaire, UPR A2167, CNRS, 91198 Gif sur Yvette, France
    Mol Cell Biol 21:8346-56. 2001
    ..and polyadenylation require the poly(A) binding protein, Pab1p, and two multiprotein complexes: CFI (cleavage factor I) and CPF (cleavage and polyadenylation factor)...
  46. ncbi The psychosocial burden on spouses of the elderly with stroke, dementia and Parkinson's disease
    Bente Thommessen
    Department of Geriatric Medicine, Ullevaal Hospital, Oslo, Norway
    Int J Geriatr Psychiatry 17:78-84. 2002
    ..66-0.69). Covariates of this factor were identified using structural equation modeling (SEM) by regression on patient's age, gender, cognitive function (MMSE), activities of daily living (ADL) and depressive symptoms (MADRS)...
  47. ncbi Characterization of the anaphylatoxin inactivator and chemotactic factor inactivator activities during cardiopulmonary bypass
    D L Kreutzer
    Department of Pathology, Veterans Administration Medical Center, Newington, CT
    J Exp Pathol 1:183-7. 1984
    ....
  48. ncbi Plasmapheresis in immune hematology: review of clinical outcome data with respect to evidence-based medicine and clinical experience
    Hans von Baeyer
    Dialysepraxis Tiergarten, Berlin, Germany
    Ther Apher Dial 7:127-40. 2003
    ..This goal can only be achieved through multiinstitutional cooperation...
  49. ncbi Estimation of left ventricular systolic function by single transpulmonary thermodilution
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Intensive Care Med 30:1377-83. 2004
    ..The global cardiac systolic function may be decreased despite preserved left ventricular function in this situation.)..
  50. ncbi Prevalence of fluorosis in children aged 6-9 years-old who participated in a milk fluoridation programme in Codegua, Chile
    Rodrigo Mariño
    School of Health, University of New England, Armidale, NSVW, Australia
    Community Dent Health 21:143-8. 2004
    ..To determine the prevalence and severity of enamel fluorosis in the permanent dentition of children aged 6-9 years old exposed to fluoride through a milk fluoridation programme in Codegua, Chile...
  51. doi Inferring relationships between health and fertility in Norwegian Red cows using recursive models
    B Heringstad
    Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, PO Box 5003, N 1432 As, Norway
    J Dairy Sci 92:1778-84. 2009
    ..The present results suggest that the use of structural-equation models, such as the one used here, may enhance our understanding of complex relationships among traits...
  52. doi Coronary collateral growth by external counterpulsation: a randomised controlled trial
    Steffen Gloekler
    University Hospital, CH 3010 Bern, Switzerland
    Heart 96:202-7. 2010
    ..Objective To test the hypothesis that ECP augments collateral function during a 1 min coronary balloon occlusion...
  53. pmc Recovery and altered neutralization specificities of chimeric viruses containing capsid protein domain exchanges from antigenically distinct strains of feline calicivirus
    J D Neill
    Metabolic Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa 50010, USA
    J Virol 74:1079-84. 2000
    ..Furthermore, the E hypervariable region of the capsid protein appears to play a major role in the formation of the antigenic structure of the virion where conformational epitopes may be more important than linear in viral neutralization...
  54. ncbi Tendons and ligaments are anatomically distinct but overlap in molecular and morphological features--a comparative study in an ovine model
    Adam P Rumian
    Department of Musculoskeletal Surgery, Imperial College, Charing Cross Hospital, London, W6 8RF, UK
    J Orthop Res 25:458-64. 2007
    ..The results of this study support the null hypothesis suggesting that the patellar tendon is similar to other tendons and demonstrate that tendons have different characteristics to ligaments...
  55. ncbi Relationships of parenting strain and mental health with family needs in mothers of severely handicapped school-aged children suffering from cerebral palsy
    Osamu Nitta
    Divison of Physical Therapy, Tokyo Metropolitan University, 7 2 10 Higashiogu, Arakawa ku, Tokyo 116 8551, Japan
    Nihon Koshu Eisei Zasshi 54:479-85. 2007
    ..The study was designed to clarify relationships of family needs of mothers of school-aged children suffering from cerebral palsy with the parenting strain and mental health...
  56. doi Fluoride and health hazards: community perception in a fluorotic area of central Rajasthan (India): an arid environment
    J Hussain
    National River Water Quality Laboratory, Central Water Commission, New Delhi, 110 016, India
    Environ Monit Assess 162:1-14. 2010
    ..Prevalence and severity of fluorosis were observed higher in subjects using tobacco, bettle nuts, and alcoholic drinks. In contrast, subjects using citrus fruits and having good nutritional status showed low prevalence...
  57. ncbi Single transpulmonary thermodilution in off-pump coronary artery bypass grafting: haemodynamic changes and effects of different anaesthetic techniques
    M Y Kirov
    Department of Anaesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russian Federation
    Acta Anaesthesiol Scand 51:426-33. 2007
    ....
  58. doi Localized complement activation in the development of protective immunity against Ostertagia ostertagi infections in cattle
    Robert W Li
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Beltsville, MD 20705, USA
    Vet Parasitol 174:247-56. 2010
    ..Increased mRNA levels of complement components C3, factor B (CFB) and factor I (CFI) in the abomasal mucosa of the infected cattle were confirmed using quantitative PCR while Western blot ..
  59. ncbi Structural model analysis of HIV risk behaviors among sexually active minority adolescents
    Nikki D Bellamy
    Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Prevention, Traumatic Stress and Special Programs, 1 Choke Cherry Road, Room 6 1003, Rockville, MD 20857, USA
    J Natl Med Assoc 100:914-24. 2008
    ..S. Department of Health and Human Services, the Substance Abuse and Mental Health Services Administration or Centers for Mental Health Services and Substance Abuse Prevention...
  60. doi Effect of milk yield characteristics, breed, and parity on success of the first insemination in Dutch dairy cows
    C Inchaisri
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Dairy Sci 93:5179-87. 2010
    ..In conclusion, knowledge of the contribution of cow factors on SFI can be applied to support decision making on the moment of insemination of an individual cow in estrus...
  61. ncbi Expressed-emotion development and course of schizophrenic illness: considerations based on results of a CFI replication
    H Schulze Mönking
    St Rochus Hospital Telgte, Germany
    Eur Arch Psychiatry Clin Neurosci 247:31-4. 1997
    ..The connection between EE index and course of illness seems not to be simply reactive or causal, but complex and non-uniform...
  62. ncbi Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease: a randomized, double-blind, placebo-controlled study
    C Seiler
    Swiss Cardiovascular Center Bern, Cardiology, University Hospital, Bern, Switzerland
    Circulation 104:2012-7. 2001
    ..Experimentally, activated macrophages have been documented to induce vascular proliferation...
  63. ncbi Relationship between pressure-derived collateral blood flow and diabetes mellitus in patients with stable angina pectoris: a study based on coronary pressure measurement
    Yilmaz Nisanci
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey
    J Invasive Cardiol 14:118-22. 2002
    ..Therefore, we sought the effects of DM on coronary collateral vessels in patients with coronary artery disease by using intracoronary pressure measurement technique...
  64. pmc Development and validation of the Chinese Quality of Life Instrument
    Kwok fai Leung
    Department of Occupational Therapy, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China
    Health Qual Life Outcomes 3:26. 2005
    ....
  65. ncbi Epilepsy and family expressed emotion: results of a prospective study
    Cinzia Bressi
    Psychiatric Clinic, Milan University, Fondazione IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milano, Italy
    Seizure 16:417-23. 2007
    ..To verify the emotional components expressed by the relatives of adult patients with a diagnosis of epilepsy, and whether they are related to adjustment to the illness and the course of the illness over time...
  66. ncbi Expressed emotion of families and the course of mood disorders: a cohort study in Japan
    Y Mino
    Department of Hygiene and Preventive Medicine, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Affect Disord 63:43-9. 2001
    ..Findings on expressed emotion (EE) of the family and the course of mood disorders have not been consistent. There has also been no report on these problems from Asia...
  67. ncbi Validity of a five-minute speech sample for the measurement of expressed emotion in the families of Japanese patients with mood disorders
    Shinji Shimodera
    Department of Neuropsychiatry, Kochi Medical School, Kohasu, Okoh cho, Nankoku Shi, Kochi, Japan
    Psychiatry Res 112:231-7. 2002
    ..Evaluation of EE by the FMSS, which is clinically applicable to patients with mood disorders, is feasible. The validity of this approach is enhanced when families defined as 'borderline low EE' are included in the high-EE category...
  68. ncbi A pharmacist model of perceived responsibility for drug therapy outcomes
    Lourdes G Planas
    Department of Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma, P O Box 26901, Oklahoma City, OK 73190, USA
    Soc Sci Med 60:2393-403. 2005
    ..These findings have implications for pharmacy practice and research...
  69. ncbi The fear-avoidance model of chronic pain: validation and age analysis using structural equation modeling
    Andrew J Cook
    Department of Anesthesiology, Division of Pain Management, University of Virginia Health System, Charlottesville, VA 22908, USA
    Pain 121:195-206. 2006
    ..Results are consistent with a FA model of chronic pain, while indicating some important age group differences in this model and in levels of pain-related fear. Longitudinal testing of the multivariate model is recommended...
  70. doi Myocardial salvage through coronary collateral growth by granulocyte colony-stimulating factor in chronic coronary artery disease: a controlled randomized trial
    Pascal Meier
    Professor of Medicine and Co Chairman of Cardiology, University Hospital, CH 3010 Bern, Switzerland
    Circulation 120:1355-63. 2009
    ..The efficacy of granulocyte colony-stimulating factor (G-CSF) for coronary collateral growth promotion and thus impending myocardial salvage has not been studied so far, to our best knowledge...
  71. doi Factor structure of a conceptual model of oral health tested among 65-year olds in Norway and Sweden
    Anne Nordrehaug Astrøm
    Institute of Clinical Dentistry, Faculty of Medicine and Odontology, University of Bergen, Bergen, Norway
    Community Dent Oral Epidemiol 38:110-9. 2010
    ..No studies have tested oral health-related quality of life models in dentate older adults across different populations...
  72. ncbi Effects of coping strategies, social support and work-nonwork conflict on shift worker's health
    A Pisarski
    Graduate School of Management, University of Queensland, Brisbane, Australia
    Scand J Work Environ Health 24:141-5. 1998
    ..This study examines the direct and mediated effects of shift workers' coping strategies and social support on structural work-nonwork conflict and subjective health...
  73. ncbi Shallow mtDNA coalescence in Atlantic pygmy angelfishes (genus Centropyge) indicates a recent invasion from the Indian Ocean
    B W Bowen
    Hawaii Institute of Marine Biology, University of Hawaii, PO Box 1346, Kaneohe, HI 96744, USA
    J Hered 97:1-12. 2006
    ..Estimates of effective female population sizes from mismatch and coalescence analyses are consistent with founder events by tens of individuals in the western Atlantic, followed by expansions to several million individuals...
  74. ncbi Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements
    Pascal Meier
    Department of Cardiology, University Hospital, CH 3010 Bern, Switzerland
    Circulation 116:975-83. 2007
    ..The goal of this study was to assess the impact on survival of quantitatively obtained, recruitable coronary collateral flow in patients with stable coronary artery disease during 10 years of follow-up...
  75. pmc Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI
    Miriam E Bucheli
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    RNA 13:1756-64. 2007
    ..Our results support a model in which balanced competition of Npl3 with mRNA processing factors may promote recognition of proper polyadenylation sites while suppressing cryptic sites...
  76. doi MDR1A (ABCB1)-deficient CF-1 mutant mice are susceptible to cerebral malaria induced by Plasmodium berghei ANKA
    Sylvie Barraud de Lagerie
    Clinical Pharmacy Unit EA 2706, University of Paris Sud 11, 5 rue JB Clement, Chatenay Malabry, 92296, France
    J Parasitol 94:1139-42. 2008
    ..CF1 and C57BL/6N mice (the reference strain) infected with PbA have similar profiles with regard to clinical signs, brain histological lesions, and brain macrophagic activation observed by immunohistological methods...
  77. ncbi Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA
    Kornelius Zeth
    EMBL Outstation Grenoble, 6 rue Jules Horowitz, BP 181, 38042 Grenoble Cedex 9, France
    Acta Crystallogr D Biol Crystallogr 58:1207-10. 2002
    ..57, c = 78.77 A, and diffract to 1.85 A resolution. Data sets collected from heavy-atom derivatives of CFI indicated the incorporation of Pt and Hg atoms. Structure solution using MIR and MAD methods is currently under way...
  78. ncbi [Development of a Japanese Version of the Work-Family Conflict Scale (WFCS), and examination of its validity and reliability]
    Izumi Watai
    Department of Community Health Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo
    Sangyo Eiseigaku Zasshi 48:71-81. 2006
    ..These results suggest that the Japanese version of the WFCS may be a reliable and valid instrument for assessing the conflict between work and family in Japanese workers...
  79. ncbi Factor structure and use of the hospital anxiety and depression scale in the homeless and socially marginalized
    Colin R Martin
    Department of Mental Health and Learning Disability, University of Sheffield, Humphry Davy House, Manvers, Sheffield, UK
    Psychol Health Med 11:190-7. 2006
    ..However, the internal consistency of the HADS anxiety (alpha = .81) and depression (alpha = .90) sub-scales was excellent. The findings of the current study suggest that the HADS is a suitable screening tool in this group...
  80. ncbi [Hemolytic uremic syndrome]
    C Mele
    Istituto di Ricerche Farmacologiche Mario Negri, Centro di Ricerche Cliniche per le Malattie Rare, Aldo e Cele Daccò, Villa Camozzi, Ranica Italy
    G Ital Nefrol 24:23-33. 2007
    ..More recent observations have also shown the involvement of genes that encode Membrane Cofactor Protein (MCP) and factor I (CFI). Genetic studies can be useful to improve therapeutic approach...
  81. doi Fragmentation of carbohydrate anomeric alkoxyl radicals: new synthesis of chiral 1-fluoro-1-halo-1-iodoalditols
    Cosme G Francisco
    Instituto de Productos Naturales y Agrobiologia, Consejo Superior de Investigaciones Cientificas, Carretera de La Esperanza 3, La Laguna, Tenerife, Spain
    Chemistry 14:6704-12. 2008
    ..The synthetic usefulness of these compounds has been preliminarily assessed by examining the reactivity of the fluorinated radical generated by rupture of the C--I bond...
  82. ncbi Factor validation of an instrument measuring group power
    Christina Leibold Sieloff
    Montana State University Bozeman, College of Nursing, Billings, MT 59101, USA
    J Nurs Meas 16:113-24. 2008
    ..Statistical support was found for the proposed model with the subsequent development of an alternate model that better fit the data. The study results indicated that the SKAGPO has acceptable psychometric properties...
  83. doi Chronic sleep reduction, functioning at school and school achievement in preadolescents
    Anne Marie Meijer
    Department of Education, University of Amsterdam, Amsterdam, The Netherlands
    J Sleep Res 17:395-405. 2008
    ..Based on the results of this study, it may be concluded that chronic sleep reduction may affect school achievement directly and indirectly via functioning at school, with worse school marks as a consequence...
  84. pmc Prophylactic plasma exchange in CD46-associated atypical haemolytic uremic syndrome
    Jean Claude Davin
    Paediatric Nephrology, Emma Children s Hospital Academic Medical Centre, Meibergdreef 9, Amsterdam ZO, The Netherlands
    Pediatr Nephrol 24:1757-60. 2009
    ..cofactor protein (CD46) are known to have a better prognosis than those with mutations in factor H (CFH) or factor I (CFI), but a small number of the former still proceed to end-stage renal failure...
  85. doi Atypical hemolytic uremic syndrome associated with complement factor H autoantibodies and CFHR1/CFHR3 deficiency
    Beom Hee Lee
    Department of Pediatrics, Kidney Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Pediatr Res 66:336-40. 2009
    ..Patients with this disease may need intensive immunosuppressive therapy in addition to plasmapheresis. Screening for CFH-Ab and the CFHR1/CFHR3 deficiency should be included in the diagnostic tests for patients with aHUS...
  86. ncbi [Coupling effect of water and nitrogen for cotton under different furrow irrigation patterns]
    Pei Ling Li
    Ministry of Education Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas, Northwest A and F University, Yangling 712100, Shaanxi, China
    Ying Yong Sheng Tai Xue Bao 20:1346-54. 2009
    ..34% was lower under FFI than under CFI. Appropriate measures for high-efficiently using water and nitrogen resources under different furrow irrigation patterns were put forward to optimize cotton yield, WUE and NUE...
  87. pmc Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosis
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Infect Immun 78:1717-27. 2010
    ..aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, bound complement control protein factor I and increased factor I cleavage of C3b to iC3b...
  88. ncbi Confirmatory factorial analysis of the Brazilian version of the Competitive State Anxiety Inventory-2 (CSAI-2)
    Eduarda Maria Coelho
    Universidade de Tras os Montes e Alto Douro, Portugal
    Span J Psychol 13:453-60. 2010
    ..2007) was the better model, because it displayed greater invariance. The use of this model was suggested in the assessment of intensity of negative thoughts and the subsequent confirmation of its psychometric properties is recommended...
  89. doi Transplantation in atypical hemolytic uremic syndrome
    David Kavanagh
    Institute of Human Genetics, Newcastle University, United Kingdom
    Semin Thromb Hemost 36:653-9. 2010
    ..Clinical trials of the complement C5 inhibitor eculizumab may improve prospects for isolated renal transplantation in individuals with complement protein mutations...
  90. pmc A new integrated variable based on thermometry, actimetry and body position (TAP) to evaluate circadian system status in humans
    Elisabet Ortiz-Tudela
    Chronobiology Laboratory, Department of Physiology, University of Murcia, Murcia, Spain
    PLoS Comput Biol 6:e1000996. 2010
    ....
  91. pmc Psychometric evaluation of the revised attribution questionnaire (r-AQ) to measure mental illness stigma in adolescents
    Melissa D Pinto
    Case Western Reserve University, School of Nursing, Cleveland, OH 44106 4904, USA
    J Nurs Meas 20:47-58. 2012
    ..659, TLI = 1.042, CFI = 1.00, RMSEA = .000). Internal consistency reliability for the scale was acceptable (a = .70). The modified r-AQ is a reliable and valid measure of the emotional reaction to people with mental illness...
  92. doi The effect of yellow pea protein and fibre on short-term food intake, subjective appetite and glycaemic response in healthy young men
    Christopher E Smith
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Room 322, Toronto, ON, Canada M5S 3E2
    Br J Nutr 108:S74-80. 2012
    ..In conclusion, protein is the component responsible for the short-term effects of yellow peas in the regulation of glycaemia and FI, but its second-meal effects disappear by 2 h post-consumption...
  93. pmc Cause or effect of arteriogenesis: compositional alterations of microparticles from CAD patients undergoing external counterpulsation therapy
    Ali Al Kaabi
    Department of Clinical Research, University of Bern, Bern, Switzerland
    PLoS ONE 7:e46822. 2012
    ..In conclusion, our data show that ECP therapy increases platelet-derived MPs in patients with CAD and that the change in protein cargo of MPs is likely in favor of a pro angiogenic/arteriogenic property...
  94. doi The construct validity of the Restraint Scale among mainland Chinese women
    Fanchang Kong
    Key Laboratory of Cognition and Personality Ministry of Education and School of Psychology, Southwest University, Chongqing, China
    Eat Behav 14:356-60. 2013
    ..The adapted scale may serve as a useful tool for identifying restrained and unrestrained eaters among Chinese women and may be particularly useful in assessing eating restraint before and after prevention and intervention programs...
  95. doi Complement factor I polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a chinese population
    Fei Yang
    Department of Ophthalmology, Peking University People s Hospital, Beijing, PR China
    Ophthalmologica 232:37-45. 2014
    To identify the associations of the two complement factor I (CFI) polymorphisms rs10033900 and rs2285714 with risk of neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a Chinese case-..
  96. ncbi Association between thrombelastography system and vascular obstructions and hemorrhage: a two-year follow-up study of elderly Chinese patients
    Qiwen Zheng
    School of Public Health, Peking University Health Science Center, No 38Xueyuan Road, Haidian District, Beijing 100191, China
    Ann Clin Lab Sci 44:194-201. 2014
    ....
  97. doi Separating mixtures by exploiting molecular packing effects in microporous materials
    Rajamani Krishna
    van t Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Phys Chem Chem Phys 17:39-59. 2015
    ..A common characteristic feature of most separations that are reliant on molecular packing effects is that adsorption and intra-crystalline diffusion are synergistic; this enhances the separation efficiencies in fixed bed adsorbers. ..
  98. doi Tag SNPs of CFI contributed to the susceptibility for non-small cell lung cancer in Chinese population
    Yingwen Liu
    Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan, 063000, China
    Tumour Biol 36:1955-62. 2015
    b>Complement factor I (CFI) plays an important role in the development of non-small cell lung cancer (NSCLC). This study aims to examine the association of CFI genetic variants with the risk of developing NSCLC in Chinese population...
  99. doi Factorial Structure and Measurement Invariance of the PANAS in Spanish Older Adults
    José Buz
    Universidad de Salamanca Spain
    Span J Psychol 18:E3. 2015
    ..It showed good reliability (PA: α = .93, NA: α = .83), criterion, convergent and discriminant validity (p < .01). Our discussion highlights the role of age and culture in the experience and expression of emotions. ..
  100. doi [In Process Citation]
    José R Blanco
    Universidad Autónoma de Chihuahua México Facultad de Ciencias de la Cultura Física DES Salud CA 121
    Nutr Hosp 33:120. 2016
    ..Conclusiones: la escala de autoeficacia en el cuidado de la alimentación y salud física es adecuada y puede usarse en estudios científicos. Futuras investigaciones deberían corroborar estos hallazgos. ..
  101. ncbi Monitoring stress among internal medicine residents: an experience-driven, practical and short measure
    Nils Myszkowski
    a Department of Psychology, Dyson College of Arts and Sciences, Pace University, New York, NY, USA
    Psychol Health Med . 2016
    ..001) and anxiety (r = .57; p < .001). Because of its short length and robust psychometric qualities, the use of the IMRSS is recommended to quickly and frequently assess and monitor stress among internal medicine residents...

Research Grants38

  1. Contact Fluorescence Imaging
    Leslie Tung; Fiscal Year: 2006
    ....
  2. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..In addition to human plasma and human plasma proteins such as fibrinogen, the developed technology will also be applicable to recombinant therapeutics, monoclonal antibodies, transgenics and vaccines. ..
  3. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..This approach is consistent with the regulatory authorities in Europe and the US that require a minimum of two virus inactivation technologies, which work by different mechanisms of action. ..
  4. In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against Myc
    Igor Gonda; Fiscal Year: 2013
    ..Aradigm already has sufficient safety data in humans and animals to support long-term clinical studies in patients with CFI and DRCFI as well as sufficient cGMP manufacturing in place to support large-scale clinical trials. ..
  5. Margaret A Pericak-Vance; Fiscal Year: 2014
    ..abstract_text> ..
  6. Planning for Long Term Care--Pilot Data Collection
    BURTON DUNLOP; Fiscal Year: 2001
    ..The research model will be refined as suggested by the data. ..
  7. CHARACTERIZATION OF CELL RECEPTORS FOR IGE AND C3
    Daniel Conrad; Fiscal Year: 1980
    ..The effect of the control proteins, beta 1 H and C3b Inactivator, on prevention of this lysis will be examined.
  8. COMPUTER ASSISTED ALCOHOL INTERVENTION IN MEDICAL CARE
    JONATHON ROSEN; Fiscal Year: 2000
    ..This fully developed CSI will have substantial appeal with primary care physicians, managed care organizations, and other purchasers. ..
  9. EYE-COM 6/MSV CAMERA: A Drowsiness Detecting Biosensor
    WILLIAM TORCH; Fiscal Year: 2001
    ..g. modafanil/stimulants in narcolepsy; L-DOPA in Parkinson's disease; alcohol or amphetamine driver impairment); as a lie-detector and as a robotic controller. ..
  10. Health Promotion for Women with Fibromyalgia
    Alexa Stuifbergen; Fiscal Year: 2006
    ..Hierarchical linear modeling techniques will be used to determine the significance of group by time interactions across the four measurement periods. ..
  11. Childhood Determinants of Adolescent / Adult Drug Use
    Judith S Brook; Fiscal Year: 2010
    ..Identification of childhood and adolescent factors that can exacerbate the impact of substance use consequences on later adult functioning would provide additional information necessary for effective treatment efforts. ..
  12. Computer-Assisted Cognitive Rehabilitation Intervention for Persons with MS
    Alexa K Stuifbergen; Fiscal Year: 2010
    ..The proposed study will test a computer-assisted cognitive rehabilitation intervention that is designed to improve both cognitive performance and cognitive competence for functioning in everyday life. ..
  13. HEALTH PROMOTION AND QUALITY OF LIFE IN CHRONIC ILLNESS
    Alexa Stuifbergen; Fiscal Year: 2009
    ..Longitudinal data will be analyzed with hierarchical linear models (HIM) and structural equation modeling techniques. ..
  14. Childhood Predictors and Consequences of Adult Smoking
    Judith Brook; Fiscal Year: 2008
    ..Identification of childhood and adolescent factors that can lessen or compensate for the impact of tobacco use on later functioning would provide additional aids for effective prevention and treatment efforts. ..
  15. ADAMTS13 Deficiency in TTP
    Han Mou Tsai; Fiscal Year: 2008
    ..abstract_text> ..
  16. HEALTH PROMOTION FOR WOMEN AT RISK FOR BREAST CANCER
    Janet Audrain McGovern; Fiscal Year: 2002
    ..The information obtained from this project should be applicable to groups at high risk for developing other cancers (e.g., colon cancer). ..
  17. HCV TRANSMISSION: SEX, VIOLENCE ALCOHOL & DRUG USE
    Marcia Russell; Fiscal Year: 2002
    ..Finally, the influence of lifetime and current drinking patterns on serum HCV RNA levels will be investigated, taking into account the effects of diet, smoking, and concomitant infections. ..
  18. Reinforcing Therapist Performance
    Bryan R Garner; Fiscal Year: 2010
    ..Cost analyses will focus on whether the increased costs of therapist incentives can be offset by improvements in these three outcomes. ..
  19. The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila
    BRENTON GRAVELEY; Fiscal Year: 2009
    ....
  20. Lumen formation during tubulogenesis in C. elegans
    Shai Shaham; Fiscal Year: 2010
    ..In addition, our studies will provide insight into tubulogenesis, a process important for the formation of all organs, defective in congenital diseases, and hyperactivated in cancer. ..
  21. Targeting Mass Media Campaigns for HIV, STD, and Pregnancy Prevention
    Philip Palmgreen; Fiscal Year: 2008
    ..The televised public service announcements will also be made available to other communities for airing there, with potentially significant public health outcomes. ..
  22. MEDICATION ADHERENCE IN LATINOS
    Esperanza Diaz; Fiscal Year: 2004
    ..leading to a Masters in Public Health. Dr. Diaz will also develop skills in descriptive and qualitative research, Data collection, Data analysis. Dr. Diaz will have an R01 proposal ready by the end of funding. ..
  23. Lifetime Drinking Patterns & HCV Treatment Outcomes
    Marcia Russell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Longitudinal Patterns and Predictors of Smoking Behavior
    Janet Audrain McGovern; Fiscal Year: 2008
    ..Results from this study can be used to inform the timing, level, type, and specific target of smoking interventions. ..
  25. A Behavioral Economic Approach to Smoking Cessation
    Janet Audrain McGovern; Fiscal Year: 2007
    ..g., adolescents, older adults) and to other contexts (e.g., prevention). ..
  26. Physical Activity and Quality of Life in Multiple Sclerosis
    Robert Motl; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. A Culturally-Based Family Therapy for Schizophrenia
    Amy Weisman; Fiscal Year: 2007
    ..The Pi's long term goal is to develop effective culturally informed family interventions for schizophrenia and related disorders, in Spanish and in English. [unreadable] [unreadable] [unreadable]..
  28. School-Based Alcohol and HIV Prevention in South Africa
    Rick Zimmerman; Fiscal Year: 2006
    ..We will also further investigate the relationships among social psychological mediating variables, individual difference variables, and alcohol and sexual risk-taking behaviors. ..
  29. New Coding Vectors for microRNA and siRNA
    Kevin Ryan; Fiscal Year: 2006
    ..abstract_text> ..
  30. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
    ..abstract_text> ..
  31. Care Planning Integrity & Nursing Home Resident Outcomes
    ROMA TAUNTON; Fiscal Year: 2004
    ..The findings regarding the elements of care planning integrity that result in the most positive outcomes for residents at the lowest cost to the facility will drive the development of new strategies to improve care. ..
  32. Effect of Tai Chi on Osteoarthritic Knee Pain in Elders with Mild Dementia
    Pao Feng Tsai; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Complement and the Clearance of Staphylococcus aureus
    KENJI CUNNION; Fiscal Year: 2006
    ..In vivo experiments will be performed using complement deficient mice. Collaborating laboratories have provided special S. aureus stains and anti-S. aureus antibodies. ..
  34. UW Center on Outcomes Research in Rehabilitation(RMI)
    Dagmar Amtmann; Fiscal Year: 2008
    ....
  35. Responses of the Ankle to Changes in Shoe Rocker Radius
    Andrew Hansen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. MECHANISM OF POLY(A)-DEPENDENT TRANSCRIPTION TERMINATION
    HAROLD MARTINSON; Fiscal Year: 2004
    ..Then the possibility is considered of using immunodepletion to identify polyA-dependent termination factors from among proteins that have already been described. ..
  37. Collaborative Alcohol Research Development and Planning
    Deborah Goebert; Fiscal Year: 2005
    ....