F13A1

Summary

Gene Symbol: F13A1
Description: coagulation factor XIII A chain
Alias: F13A, coagulation factor XIII A chain, FSF, A subunit, TGase, bA525O21.1 (coagulation factor XIII, A1 polypeptide), coagulation factor XIII, A polypeptide, coagulation factor XIII, A1 polypeptide, coagulation factor XIIIa, factor XIIIa, fibrin stabilizing factor, A subunit, fibrinoligase, protein-glutamine gamma-glutamyltransferase A chain, transglutaminase A chain, transglutaminase. plasma
Species: human

Top Publications

  1. ncbi Nonlipidized juvenile xanthogranuloma: a histologic and immunohistochemical study
    C C Newman
    Department of Dermatology, University of Texas Medical Branch, Galveston 77555-0783, USA
    Pediatr Dermatol 14:98-102. 1997
  2. ncbi Dermal dendrocytes participate in the cellular pathology of experimental acute graft-versus-host disease
    Y H Yoo
    Department of Anatomy and Cell Biology, Dong A University College of Medicine, Pusan, South Korea
    J Cutan Pathol 25:426-34. 1998
  3. ncbi Transglutaminase activity in the eye: cross-linking in epithelia and connective tissue structures
    M Raghunath
    Department of Dermatology, University of Munster, Germany
    Invest Ophthalmol Vis Sci 40:2780-7. 1999
  4. ncbi Chicken coagulation factor XIIIA is produced by the theca externa and stabilizes the ovarian follicular wall
    B Recheis
    Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Vienna A 1030, Austria
    J Biol Chem 275:35320-7. 2000
  5. ncbi Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss
    Astrid Dossenbach-Glaninger
    Department of Laboratory Medicine, Rudolfstiftung Hospital, Juchgasse 25, A 1030 Vienna, Austria
    Clin Chem 49:1081-6. 2003
  6. pmc Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor
    A Ichinose
    Department of Biochemistry, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:5829-33. 1988
  7. ncbi The Val34Leu polymorphism in the A subunit of coagulation factor XIII contributes to the large normal range in activity and demonstrates that the activation peptide plays a role in catalytic activity
    S Kangsadalampai
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Blood 92:2766-70. 1998
  8. ncbi Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women
    A P Reiner
    Department of Medicine, Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Stroke 32:2580-6. 2001
  9. ncbi Factor XIII Val34Leu polymorphism in primary intracerebral haemorrhage
    J Corral
    Department of Hematology and Clinical Oncology, Hospital General Universitario, 3000 Murcia, Spain
    Hematol J 1:269-73. 2000
  10. ncbi Is the factor XIII 34Val/Leu polymorphism a protective factor for cerebrovascular disease?
    Georg Endler
    Department of Laboratory Medicine, University Vienna Medical School, Austria
    Br J Haematol 120:310-4. 2003

Research Grants

  1. MOLECULAR DEFECTS OF FIBRIN STABILIZATION
    Laszlo Lorand; Fiscal Year: 2002
  2. COAGULATION OF BLOOD
    Laszlo Lorand; Fiscal Year: 1999
  3. ROLE OF FACTOR XIII BINDING TO THE HEMOSTATIC PLUG
    Charles Greenberg; Fiscal Year: 1993
  4. BIOLOGY OF FACTOR XIII
    JAN MC DONAGH; Fiscal Year: 1992
  5. Hormone Replacement Therapy and Prothrombotic Variants
    Bruce Psaty; Fiscal Year: 2005
  6. THROMBUS DETECTION USING FIBRIN-SPECIFIC ANTIBODIES
    Gary Matsueda; Fiscal Year: 1992
  7. METAL DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 2002
  8. BENJAMIN ALEXANDER RABY; Fiscal Year: 2015
  9. THE ROLE OF CONTRACTILE PROTEINS IN PLATELETS
    ELENA PUSZKIN; Fiscal Year: 1990
  10. TRANSGLUTAMINASE INHIBITORS AND SOLID PHASE SUBSTRATES
    MARY TRAWICK; Fiscal Year: 1991

Patents

  1. Production of factor XIIIa by gene technology

Detail Information

Publications272 found, 100 shown here

  1. ncbi Nonlipidized juvenile xanthogranuloma: a histologic and immunohistochemical study
    C C Newman
    Department of Dermatology, University of Texas Medical Branch, Galveston 77555-0783, USA
    Pediatr Dermatol 14:98-102. 1997
    ..Immunoperoxidase staining was done. All lesions are consistently positive for factor XIIIa as opposed to only focally positive or negative in CJXG and negative in Langerhans cell histiocytosis (LCH)...
  2. ncbi Dermal dendrocytes participate in the cellular pathology of experimental acute graft-versus-host disease
    Y H Yoo
    Department of Anatomy and Cell Biology, Dong A University College of Medicine, Pusan, South Korea
    J Cutan Pathol 25:426-34. 1998
    ..Previous studies suggest that factor XIIIa-positive dermal dendrocytes may be involved in the pathogenesis of disorders involving antigen presentation to ..
  3. ncbi Transglutaminase activity in the eye: cross-linking in epithelia and connective tissue structures
    M Raghunath
    Department of Dermatology, University of Munster, Germany
    Invest Ophthalmol Vis Sci 40:2780-7. 1999
    To assess the distribution of transglutaminase (TGase) activity in ocular tissues and the target structures for cross-linking.
  4. ncbi Chicken coagulation factor XIIIA is produced by the theca externa and stabilizes the ovarian follicular wall
    B Recheis
    Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Vienna A 1030, Austria
    J Biol Chem 275:35320-7. 2000
    ..mRNA display analysis of defined phases of follicle development resulted in the characterization of coagulation factor XIIIA. It is expressed and produced by cells of the theca externa in a highly regulated manner during distinct ..
  5. ncbi Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss
    Astrid Dossenbach-Glaninger
    Department of Laboratory Medicine, Rudolfstiftung Hospital, Juchgasse 25, A 1030 Vienna, Austria
    Clin Chem 49:1081-6. 2003
    ..Two polymorphisms, coagulation factor XIII (FXIII) Val34Leu and plasminogen activator inhibitor 1 (PAI-1) 4G/5G, interfere with fibrin cross-linking and regulation of fibrinolysis and may therefore contribute to early pregnancy loss...
  6. pmc Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor
    A Ichinose
    Department of Biochemistry, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:5829-33. 1988
    ....
  7. ncbi The Val34Leu polymorphism in the A subunit of coagulation factor XIII contributes to the large normal range in activity and demonstrates that the activation peptide plays a role in catalytic activity
    S Kangsadalampai
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Blood 92:2766-70. 1998
    ....
  8. ncbi Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women
    A P Reiner
    Department of Medicine, Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Stroke 32:2580-6. 2001
    ....
  9. ncbi Factor XIII Val34Leu polymorphism in primary intracerebral haemorrhage
    J Corral
    Department of Hematology and Clinical Oncology, Hospital General Universitario, 3000 Murcia, Spain
    Hematol J 1:269-73. 2000
    ..The aim of our study was to investigate the role of this polymorphism in patients with primary intracerebral haemorrhage from a distinct population...
  10. ncbi Is the factor XIII 34Val/Leu polymorphism a protective factor for cerebrovascular disease?
    Georg Endler
    Department of Laboratory Medicine, University Vienna Medical School, Austria
    Br J Haematol 120:310-4. 2003
    ..Thus, screening for the FXIII Val34Leu polymorphism will not contribute significantly to the risk prediction of cerebrovascular disease...
  11. ncbi Factor XIII subunit A as an intracellular transglutaminase
    R Adany
    Department of Preventive Medicine, School of Public Health, Medical and Health Sciences Center, University of Debrecen, 4032 Debrecen, Hungary
    Cell Mol Life Sci 60:1049-60. 2003
    ..Cytoplasmic expression has a very close relationship with phagocytic activities. Further research is needed to understand the biological significance of its nuclear presentation...
  12. ncbi Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls
    Juan P Casas
    Centre for Clinical Pharmacology, British Heart Foundation Laboratories at University College London, London, England
    Arch Neurol 61:1652-61. 2004
    ..These findings have important implications for the design of future genetic studies and for predictive genetic testing for stroke and other multifactorial diseases...
  13. ncbi Coagulation factor XIII VaI34Leu polymorphism in patients with small vessel disease or primary intracerebral hemorrhage
    Agnieszka Slowik
    Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Cerebrovasc Dis 19:165-70. 2005
    ..The aim of the study was to investigate the association between the FXIII Val34Leu polymorphism and the risk of ischemic stroke due to small vessel disease (SVD) or the risk of primary intracerebral hemorrhage (PICH)...
  14. ncbi Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis
    Philip S Wells
    Faculty of Medicine, Department of Medicine, University of Ottawa, Ontario, Canada
    Am J Epidemiol 164:101-9. 2006
    It has been suggested that a G-to-T transition in exon 2 of the factor XIIIA gene resulting in a substitution of leucine for valine at amino acid 34 (FXIII Val34Leu) protects against venous thromboembolism (VTE)...
  15. ncbi Factor XIII Val34Leu variant protects against coronary artery disease. A meta-analysis
    Zoltán Vokó
    Department of Preventive Medicine, Faculty of Public Health, Medical and Health Science Centre, University of Debrecen, Kassai út 26 b, 4028 Debrecen, Hungary
    Thromb Haemost 97:458-63. 2007
    ..Data published in the literature suggest that gene-gene and gene-environmental interactions might significantly influence the protective effect of FXIII-A Val34Leu polymorphism...
  16. pmc The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St Suite 300, Minneapolis, MN 55454, USA
    Thromb Res 121:1-7. 2007
    ..However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study...
  17. ncbi Increased risk for oral cancer is associated with coagulation factor XIII but not with factor XII
    Eleftherios Vairaktaris
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens 11521, Greece
    Oncol Rep 18:1537-43. 2007
    ..Nevertheless, this thinner and less porous fibrin network inhibits cell migration...
  18. ncbi Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension
    J Suntharalingam
    Pulmonary Vascular Diseases Unit, Papworth Hospital, Papworth Everard
    Eur Respir J 31:736-41. 2008
    ..An association between this polymorphism and chronic thromboembolic pulmonary hypertension, therefore, supports an embolic aetiology for this disease, and may provide a mechanism by which thrombus persists following an acute event...
  19. pmc The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults
    George Peck
    Imperial College Cerebrovascular Research Unit ICCRU, Department of Clinical Neuroscience, Imperial College London and Hammersmith Hospitals, London, UK
    PLoS ONE 3:e3691. 2008
    ..A meta-analysis of all candidate gene association studies of haemorrhagic stroke (including ruptured subarachnoid haemorrhage and amyloid angiopathy-related haemorrhage) was performed, allowing more reliable estimates of risk...
  20. doi Association between factor XIII single nucleotide polymorphisms and aneurysmal subarachnoid hemorrhage
    Claes Ladenvall
    Institute of Neuroscience and Physiology, Department of Neuroscience and Rehabilitation, The Sahlgrenska Academy at the University of Gothenburg, Sweden
    J Neurosurg 110:475-81. 2009
    ..The authors investigate associations between putative functional variants in genes of importance for fibrinolysis and aSAH and/or outcome following aSAH...
  21. pmc Genes influencing coagulation and the risk of aneurysmal subarachnoid hemorrhage, and subsequent complications of secondary cerebral ischemia and rebleeding
    Ynte M Ruigrok
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, PO Box 85500, 3500 GA Utrecht, The Netherlands
    Acta Neurochir (Wien) 152:257-62. 2010
    ..We investigated whether genes influencing coagulation are associated with the occurrence of aneurysmal subarachnoid hemorrhage (SAH) and with secondary cerebral ischemia and rebleeding in patients with aneurysmal SAH...
  22. ncbi Electron microscopy and hydrodynamic properties of factor XIII subunits
    N A Carrell
    Department of Anatomy, Duke University Medical Center, Durham, North Carolina 22710
    J Biol Chem 264:551-6. 1989
    ..Our model for the A2B2 zymogen has the elongated A2 dimer forming the core and the two B strands wrapping around the outside...
  23. ncbi Congenital blood coagulation factor XIII deficiency and successful deliveries: a review of the literature
    Toshihiko Asahina
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Obstet Gynecol Surv 62:255-60. 2007
    ..women with a congenital deficiency of A-subunit of factor XIII (XIIIA), in which the plasma level of maternal factor XIIIA and/or the precise replacement therapies are described...
  24. pmc Identification of eight novel coagulation factor XIII subunit A mutations: implied consequences for structure and function
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, 53127 Bonn, Germany
    Haematologica 95:956-62. 2010
    ..In most cases, the disease is caused by F13A gene mutations. Causative mutations associated with the F13B gene are rarer.
  25. ncbi The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolism
    G L Reed
    Harvard School of Public Health, Harvard Medical School, and Massachusetts General Hospital, Boston, MA, USA
    Circulation 99:299-304. 1999
    ..This study examines the contribution of activated factor XIII (factor XIIIa) to fibrinolytic resistance in experimental pulmonary embolism.
  26. ncbi Factor XIII improves gastric stress lesions in rats
    G D'Argenio
    Gastrointestinal Unit, School of Medicine, Federico II University, Naples, Italy
    Digestion 63:220-8. 2001
    ..The present experiments aimed at examining whether plasma transglutaminase (factor XIIIa) contributes to such healing and at evaluating whether factor XIII supplementation improves gastric mucosal ..
  27. ncbi Development and evaluation of ELISAs for factor XIIIA and XIIIB subunits in plasma
    P J Murdock
    Haemophilia Centre, Royal Free Hampstead, London, UK
    Thromb Res 67:73-9. 1992
    ..However, a moderate reduction in the plasma level of the functional subunit (factor XIIIA) and also to a lesser extent of the carrier subunit (factor XIIIB), and a decrease in the XIIIA:B subunit ratio,..
  28. ncbi Immunohistochemical detection of coagulation factor XIIIa in postmortem human brain tissue
    H Akiyama
    Tokyo Institute of Psychiatry, Japan
    Neurosci Lett 202:29-32. 1995
    ..A smaller form of factor XIII called factor XIIIa (FXIIIa) occurs intracellularly in platelets, monocytes and peripheral macrophages...
  29. ncbi Angiogenic histogenesis of stromal cells in hemangioblastoma: ultrastructural and immunohistochemical study
    B Lach
    Department of Laboratory Medicine and Pathology, University of Ottawa, Canada
    Ultrastruct Pathol 23:299-310. 1999
    ..SC were less commonly immunoreactive for desmin, factor XIIIa, and Ricinus communis lectin receptors, and only occasionally for factor VIII and Ulex europeus lectin...
  30. pmc Clots of beta-fibrin. Viscoelastic properties, temperature dependence of elasticity, and interaction with fibrinogen-binding tetrapeptides
    A Shimizu
    Department of Chemistry, University of Wisconsin, Madison 53706
    Biophys J 53:311-8. 1988
    ..A ligated beta-fibrin clot formed with Factor XIIIa (in which the activating thrombin had been neutralized by hirudin) showed essentially perfect elastic behavior, ..
  31. ncbi Multinucleated giant stromal tumor of the omentum: report of a case with immunohistochemical and ultrastructural investigation
    K W Min
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Ultrastruct Pathol 20:89-99. 1996
    ..for actin along the periphery of the cytoplasm, and negative for cytokeratin, EMA, myoglobin, S-100, CEA, Factor XIIIa, HMB-45, and HAM56 and KP-1...
  32. doi Mutations affecting disulphide bonds contribute to a fairly common prevalence of F13B gene defects: results of a genetic study in 14 families with factor XIII B deficiency
    V Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
    Haemophilia 16:675-82. 2010
    ..suspected FXIII deficiency and one patient with severe (homozygous) FXIII deficiency were screened for mutations in F13A and F13B genes...
  33. ncbi Immunohistochemical and electron microscopic profiles of cutaneous Kaposi's sarcoma and bacillary angiomatosis
    M Kostianovsky
    Department of Pathology and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Ultrastruct Pathol 16:629-40. 1992
    ..Macrophage/monocyte markers used were alpha 1-antitrypsin, lysosome, Kp1 (CD68), and polyclonal factor XIIIa. Electron microscopic studies demonstrated that most of the spindle cells in KS showed a paucity of cell ..
  34. ncbi Fibrinogen Haifa: fibrinogen variant with absence of protective effect of calcium on plasmin degradation of gamma chains
    J Soria
    , , Paris, France
    Thromb Haemost 57:310-3. 1987
    ..binding to fibrinogen, ADP--platelet aggregation cofactor activity and gamma dimerization process induced by factor XIIIa are normal for fibrinogen Haifa, the corresponding sequences in the gamma chain are not involved...
  35. ncbi Angiogenic process in bacillary angiomatosis
    M Kostianovsky
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
    Ultrastruct Pathol 18:349-55. 1994
    ..The macrophage/monocyte markers used were alpha 1-antitrypsin, lysosome, kp1 (CD68), and polyclonal factor XIIIa; these revealed a sprinkle of positive cells ranging from 10% to 20% of the cell population...
  36. ncbi Dermal dendrocytes in Dupuytren's disease: a link between the skin and pathogenesis?
    P Sugden
    Department of Pathological Sciences, University of Manchester, Salford, UK
    J Hand Surg Br 18:662-6. 1993
    The skin has previously been implicated in the process of Dupuytren's disease. The dermal dendrocyte is a factor XIIIa positive cell, which has been found in normal skin and some pathological conditions associated with fibrosis...
  37. ncbi Expression of 67-kDa elastin receptor in annular elastolytic giant cell granuloma: elastin peptides induce monocyte-derived dendritic cells or macrophages to form granuloma in vitro
    Norihiro Fujimoto
    Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Exp Dermatol 13:179-84. 2004
    ..Proliferation of factor XIIIa(+) cells and CD68(+) cells was also seen in the lesional skins of AEGCG...
  38. ncbi Sclerosing dermatofibrosarcoma protuberans (DFSP): an unusual variant with focus on the histopathologic differential diagnosis
    Vicente Sabater-Marco
    Department of Pathology, Consorcio General Hospital, Universitario de Valencia, Spain
    Int J Dermatol 45:59-62. 2006
    ..Denmark), HHF-35 (Enzo Diagnostics, Farmingdale NY), cytokeratin (AE1/AE3) (Biogenex, San Ramon, CA), and factor XIIIa (Calbiochem Novabiochem Corporation, La Jolla, CA)...
  39. doi Immunohistochemical aspects of the fibrogenic pathway in nephrogenic systemic fibrosis
    Pascale Quatresooz
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Appl Immunohistochem Mol Morphol 18:448-52. 2010
    ..Immunohistochemistry was done using antibodies directed to vimentin, CD34, Factor XIIIa, calprotectin, α-smooth muscle actin, Ulex europaeus agglutinin-1 (UEA-1), and MIB1/Ki67 and to ..
  40. ncbi Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34
    H J Kim
    Department of Dermatology, School of Medicine and Medical Research Institute, Chungbuk National University, 62 Gaesin dong, Heungdeok Gu, Cheongju, Chungbuck 361 711, Korea
    Br J Dermatol 157:319-24. 2007
    ..Recent studies demonstrated that DFs expressed ST3, whereas DFSPs were only rarely ST3 positive...
  41. ncbi Effect of a synthetic carboxy-terminal peptide of alpha(2)-antiplasmin on urokinase-induced fibrinolysis
    Kyung N Lee
    William K Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Thromb Res 105:263-70. 2002
    ..The AP26 peptide also inhibited factor XIIIa-catalyzed crosslinking of fibrin alpha-chains, and this also accelerated lysis of fibrin. EACA had no effect...
  42. pmc Assignment of autosomal dominant spinocerebellar ataxia (SCA1) centromeric to the HLA region on the short arm of chromosome 6, using multilocus linkage analysis
    H Y Zoghbi
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030
    Am J Hum Genet 44:255-63. 1989
    ..markers are the cDNA for the beta-subunit of HLA-DP, which is centromeric to HLA-(A-B), and the cDNA for coagulation factor XIIIa (F13A), which is telomeric to HLA-(A-B)...
  43. ncbi Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity
    Ning Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06504 8900, USA
    Am J Dermatopathol 26:267-72. 2004
    ..CD34 and Factor XIIIa staining is commonly used in separating DF from DFSP, but is not always helpful...
  44. ncbi Increased submucosal factor XIIIa-positive dendrocytes in oral lichen planus
    J A Regezi
    Division of Oral Pathology, School of Dentistry, University of California, San Francisco 94143 0424
    J Oral Pathol Med 23:114-8. 1994
    b>Factor XIIIa+ "dendrocytes", normal residents of the submucosa and dermis, are a morphologically and phenotypically distinctive subset of the monocyte-macrophage system...
  45. doi Collagen triple helix repeat containing-1 in the differential diagnosis of dermatofibrosarcoma protuberans and dermatofibroma
    L Wang
    Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Br J Dermatol 164:135-40. 2011
    ..To our knowledge, however, expression of Cthrc1 in DFSP and DF has not been studied before...
  46. ncbi Transglutaminase factor XIIIA in the cartilage of developing avian long bones
    M V Nurminskaya
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Dyn 223:24-32. 2002
    Previously, we showed that mRNA for transglutaminase factor XIIIA (FXIIIA) is up-regulated in the hypertrophic zone of the growth plate of the chicken tibiotarsus, a well-characterized model of long bone development...
  47. ncbi Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry
    Dirk Janssen
    Department of Pediatric Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 29:21-8. 2005
    ..Immunohistochemistry included antibodies against macrophages (Ki-M1P), S-100 protein, CD1a, and factor XIIIa (FXIIIa). Clinical data were obtained by means of a standardized questionnaire...
  48. ncbi Human herpesvirus 8 and iron staining are useful in differentiating Kaposi sarcoma from interstitial granuloma annulare
    David A Wada
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132 2409, USA
    Am J Clin Pathol 127:263-70. 2007
    ..were stained for iron, Hale colloidal iron, human herpesvirus 8 (HHV-8), CD31, CD34, CD68, collagen IV, factor XIIIa, and MIB-1...
  49. ncbi Position of gamma-chain carboxy-terminal regions in fibrinogen/fibrin cross-linking mixtures
    K R Siebenlist
    Department of Biomedical Sciences, College of Health Sciences, Marquette University, P O Box 1881, Milwaukee, Wisconsin 53233 1881, USA
    Biochemistry 39:14171-5. 2000
    ..To distinguish between these two possibilities, the gamma dimer composition of factor XIIIa-cross-linked fibrin/fibrinogen complexes that had been formed through noncovalent D/E interactions between ..
  50. ncbi Fibrinogen assembly and crosslinking on a fibrin fragment E template
    Michael W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, Milwaukee 53201 2178, USA
    Thromb Haemost 87:651-8. 2002
    ..observed that fibrinogen fibrils that had been assembled on a fibrin fragment E template, cross-linked with factor XIIIa, and then dissociated in acetic acid solution, were aligned end-to-end...
  51. ncbi Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A
    M Hirota-Kawadobora
    Department of Pathology, Shinshu University School of Medicine, Shinshu University Hospital, Japan
    J Thromb Haemost 2:1359-67. 2004
    ..Since gamma Arg275His mutations have also been reported in 10 families, we synthesized recombinant gamma 275His fibrinogen and gamma 275Ala fibrinogen (as a control) and analyzed and compared them with gamma 275Cys and gamma 275Arg...
  52. doi D-dimer antigen: current concepts and future prospects
    Soheir S Adam
    University of North Carolina, Chapel Hill, NC 27599 7305, USA
    Blood 113:2878-87. 2009
    ..is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin...
  53. ncbi Characterization of factor XIIIa+ dendritic cells in dermatofibroma: Immunohistochemical, electron and immunoelectron microscopical observations
    Ying Song
    Division of Dermatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    J Dermatol Sci 39:89-96. 2005
    ....
  54. pmc Interaction of the fibronectin COOH-terminal Fib-2 regions with fibrin: further characterization and localization of the Fib-2-binding sites
    Evgeny Makogonenko
    Center for Vascular and Inflammatory Diseases and the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biochemistry 46:5418-26. 2007
    ..Fib-1 regions of fibronectin (one on each chain) and the alphaC-regions of fibrin, and is further reinforced by factor XIIIa-mediated covalent cross-linking of fibronectin to the fibrin matrix...
  55. doi Expression of nestin in dermatofibrosarcoma protuberans in comparison to dermatofibroma
    Toru Mori
    Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
    J Dermatol 35:419-25. 2008
    ..In those instances, CD34 and factor XIIIa have been used as valuable differential markers...
  56. ncbi Oral lichen planus and dermal dendrocytes
    A L Cardozo
    Sector of Dermatology and Post Graduation Course, HUCFF UFRJ and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Actas Dermosifiliogr 100:46-52. 2009
    ..been fully elucidated although it is known to be mediated by lymphocytes with the participation of cytokines and other inflammatory cells, including type I and type II dermal dendrocytes (DD) (factor XIIIa+ DD and CD34+ DD, respectively).
  57. ncbi Factor XIIIa positive dendritic cells are a major accessory cell population in the elicitation phase of DNCB-induced contact hypersensitivity
    E Jorundsson
    Department of Morphology, Genetics and Aquatic Biology, Norwegian School of Veterinary Science, Oslo
    Vet Immunol Immunopathol 71:99-113. 1999
    ..b>Factor XIIIa+ (FXIIIa+) cells were prominent in the superficial dermis and showed predominantly a perivascular and ..
  58. ncbi Immunocompetent cells in the pulp of human deciduous teeth
    A Angelova
    Developmental Oral Health Science, Department of Orofacial Development and Function, Graduate School, Tokyo Medical and Dental University, 5 45 Yushima 1 chome, Bunkyo ku, 113 8549, Tokyo, Japan
    Arch Oral Biol 49:29-36. 2004
    ..of resorption were subjected to immunoperoxidase staining with the use of antibodies directed to HLA-DR, CD68, factor XIIIa and lymphocyte subsets...
  59. pmc Transglutaminase activity in the hematopoietic tissue of a crustacean, Pacifastacus leniusculus, importance in hemocyte homeostasis
    Xionghui Lin
    Department of Comparative Physiology, Uppsala University, Norbyvagen 18A, SE 752 36 Uppsala, Sweden
    BMC Immunol 9:58. 2008
    ..form a group of enzymes that have many different substrates and among the most well known are fibrin for Factor XIIIa and the clotting protein in crustaceans...
  60. ncbi Thymosin beta4 is released from human blood platelets and attached by factor XIIIa (transglutaminase) to fibrin and collagen
    Thomas Huff
    Institute of Biochemistry, Faculty of Medicine, University Erlangen Nuremberg, 91054 Erlangen, Germany
    FASEB J 16:691-6. 2002
    ..We suggest that thymosin beta4 cross-linking is mediated by factor XIIIa, a transglutaminase that is coreleased from stimulated platelets...
  61. ncbi Immunoprofile of endocervical and endometrial stromal cells and its potential application in localization of tumor involvement
    Julieta E Barroeta
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Int J Gynecol Pathol 26:76-82. 2007
    ..hyperplasia (n = 16) were stained with antibodies to CD10, Wilms Tumor-1, CD34, smooth muscle actin, and factor XIIIa by immunohistochemistry. In 16 cases, lower uterine segment was also available...
  62. doi Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone
    Christelle Sanchez
    University of Liege, Sart Tilman, Liege, Belgium
    Arthritis Rheum 58:442-55. 2008
    ..To determine the phenotype of osteoblasts from the sclerotic zones of human osteoarthritic (OA) subchondral bone...
  63. ncbi Substitution of the gamma-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking
    Nobuo Okumura
    Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Blood 103:4157-63. 2004
    ..polymerization by turbidity, fibrinopeptide release by high-performance liquid chromatography, and factor XIIIa-catalyzed cross-linking by sodium dodecyl sulfate-polyacrylamide gel electrophoresis...
  64. ncbi Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma
    Zoltan Szollosi
    Department of Pathology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
    Pathol Res Pract 201:369-77. 2005
    ..A large number of fibroblast-like and pleomorphic cells express factor XIIIa in MFH...
  65. ncbi Expression and localization of plasma transglutaminase factor XIIIA in bone
    Yukiko Nakano
    Faculty of Dentistry, McGill University, Strathcona Bldg Room M 72, 3640 University Street, Montreal, QC, Canada H3A
    J Histochem Cytochem 55:675-85. 2007
    ..that in addition to transglutaminase 2 (TG2), cultured MC3T3-E1 osteoblasts also express the plasma TG Factor XIIIA (FXIIIA)...
  66. pmc Factor XIIIA mobilizes transglutaminase 2 to induce chondrocyte hypertrophic differentiation
    Kristen A Johnson
    Veterans Affairs Medical Center, UCSD, La Jolla, CA 92161, USA
    J Cell Sci 121:2256-64. 2008
    Two transglutaminases (TGs), factor XIIIA (FXIIIA) and TG2, undergo physiologic upregulation in growth plate hypertrophic chondrocytes, and pathological upregulation in osteoarthritic cartilage...
  67. ncbi S100A6 expression in fibrohistiocytic lesions
    D R Fullen
    Department of Pathology, University of Michigan Hospitals, Ann Arbor, Michigan, USA
    J Cutan Pathol 28:229-34. 2001
    ..We evaluated a variety of cutaneous fibrohistiocytic lesions to determine if the immunophenotype of S100A6 positivity can be expanded to include some or all of these lesions...
  68. doi CD1a and factor XIIIa immunohistochemistry in leprosy: a possible role of dendritic cells in the pathogenesis of Mycobacterium leprae infection
    Juarez Antônio Simões Quaresma
    Laboratorio de Imunopatologia, Nucleo de Medicina Tropical, Universidade Federal do Para, UFPA, Belem PA, Brazil
    Am J Dermatopathol 31:527-31. 2009
    ..by epidermal Langerhans cells and dermal dendrocytes, which can be identified by expression of CD1a and factor XIIIa (FXIIIa)...
  69. ncbi Covalently conjugated VEGF--fibrin matrices for endothelialization
    A H Zisch
    Department of Materials and Institute for Biomedical Engineering, ETH and University of Zurich, Moussonstrasse 18, 8044 Zurich, Switzerland
    J Control Release 72:101-13. 2001
    ..that allows the covalent incorporation of exogenous bioactive peptides by the transglutaminase activity of factor XIIIa into fibrin during coagulation...
  70. ncbi Cross-linking of the NH2-terminal region of fibronectin to molecules of large apparent molecular mass. Characterization of fibronectin assembly sites induced by the treatment of fibroblasts with lysophosphatidic acid
    Q Zhang
    Departments of Medicine and Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 271:33284-92. 1996
    ..that bind 125I-labeled fibronectin or its 70-kDa N-terminal fragment were identified by cross-linking with factor XIIIa and by photoaffinity labeling...
  71. ncbi The core domain of the tissue transglutaminase Gh hydrolyzes GTP and ATP
    S E Iismaa
    Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW, 2010, Australia
    Biochemistry 36:11655-64. 1997
    ..Based on its homology with factor XIIIA, an extracellular transglutaminase, the structure of TGase II is likely composed of an N-terminal beta-sandwich ..
  72. ncbi GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket
    S E Iismaa
    Molecular Cardiology Unit, Victor Chang Cardiac Research Institute and Arthritis and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Biol Chem 275:18259-65. 2000
    ..162-179 of G(h) were substituted with the equivalent but nonhomologous region of the non-GTP-binding TGase factor XIIIA) and a G(h) point mutant, S171E, retained TGase activity but failed to bind and hydrolyze GTP and did not ..
  73. ncbi Use of D-dimer assays in the diagnosis of venous thrombosis
    C E Dempfle
    University of Heidelberg, Mannheim University Hospital, I Department of Medicine, Germany
    Semin Thromb Hemost 26:631-41. 2000
    ..fibrin formation, the D-domains of adjacent fibrin molecules within the fibrin polymer are covalently linked by factor XIIIa, leading to the formation of a D-domain dimer...
  74. ncbi Factor XIIIa-related antigen immunoreactivity of fungal cell wall: a biologically relevant feature?
    J E Arrese
    Department of Dermatopathology, University of Liege, Belgium
    Dermatology 190:119-23. 1995
    A positive immunoreactivity of fungal walls for factor XIIIa has been recently described. Factor XIIIa is a transglutaminase involved in the formation of covalent peptide bounds between some specific proteins.
  75. ncbi On the activation of bovine plasma factor XIII. Amino acid sequence of the peptide released by thrombin and the terminal residues of the subunit polypeptides
    S Nakamura
    J Biochem 78:1247-66. 1975
    ..In the conversion of Factor XIII to the active enzyme, Factor XIIIa, by bovine thrombin [EC 3.4.21.5], a peptide was liberated...
  76. ncbi Transglutaminase II: a new class of GTP-binding protein with new biological functions
    M J Im
    Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    Cell Signal 9:477-82. 1997
    Tissue type transglutaminase (TGase II) is historically a member of the transglutaminase family, which covalently cross-links cellular proteins and polyamines...
  77. ncbi New splicing mutations in the human factor XIIIA gene, each producing multiple mutant transcripts of varying abundance
    R Anwar
    Department of Medicine, University of Leeds, St James s University Hospital, UK
    Thromb Haemost 79:1151-6. 1998
    ..The precise molecular mechanisms which result in these variant transcripts, and their relative abundance in our FXIII deficient patients, are discussed...
  78. ncbi "Juvenile" xanthogranuloma: an immunophenotypic study with a reappraisal of histogenesis
    M D Kraus
    Department of Pathology, Washington University Medical Center, St Louis, Missouri 63110
    Am J Dermatopathol 23:104-11. 2001
    ..The dermal dendrocyte was previously proposed as the cell of origin for JXG on the basis of Factor XIIIa reactivity, a suggestion that does not fully explain the occasional xanthogranulomatous proliferations ..
  79. ncbi Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms
    Robert A S Ariens
    Academic Unit of Molecular Vascular Medicine, University of Leeds School of Medicine, United Kingdom
    Blood 100:743-54. 2002
    ..Fibrin is the main protein constituent of the blood clot, which is stabilized by factor XIIIa through an amide or isopeptide bond that ligates adjacent fibrin monomers...
  80. ncbi Long-lasting "christmas tree rash" in an adolescent: isotopic response of indeterminate cell histiocytosis in pityriasis rosea?
    Andreas Wollenberg
    Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany
    Acta Derm Venereol 82:288-91. 2002
    ..The lymphohistiocytic infiltrate in the upper dermis showed mononuclear cells immunoreactive with S100, CD68, factor XIIIa and CD1a...
  81. ncbi Polymorphisms of genes affecting thrombosis and risk of myocardial infarction
    S Kakko
    Department of Internal Medicine, University of Oulu, PO Box 5000, FIN 90014, Oulu, Finland
    Eur J Clin Invest 32:643-8. 2002
    ..As thrombosis is an essential factor in the pathogenesis of acute myocardial infarction (AMI), the genes of proteins affecting haemostasis are good candidate genes for AMI...
  82. ncbi Thyroxine stimulates transglutaminase activity in articular chondrocytes
    A K Rosenthal
    Zablocki VA Medical Center and Medical College of Wisconsin, Division of Rheumatology, Department of Medicine, Milwaukee, WI, USA
    Osteoarthritis Cartilage 11:463-70. 2003
    ..Elevated activity levels of the two transglutaminase (Tgase) enzymes (type II Tgase and Factor XIIIA (FXIIIA)) have recently been described as additional features of hypertrophic growth plate chondrocytes...
  83. ncbi Relationship between liver injury and transglutaminase activities in guinea pigs and rats
    Naoko Sato
    Department of Radiopharmacy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Biol Pharm Bull 27:236-8. 2004
    We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats...
  84. ncbi Role of transglutaminase 1 in stabilisation of intercellular junctions of the vascular endothelium
    Werner Baumgartner
    Institute of Anatomy and Cell Biology, University of Wurzburg, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Histochem Cell Biol 122:17-25. 2004
    ..Simultaneous inhibition of intracellular and extracellular TGase activity by monodansylcadaverine (MDC) strongly weakened barrier properties of MyEnd monolayers, whereas ..
  85. ncbi Transglutaminase contributes to CPPD crystal formation in osteoarthritis
    David Heinkel
    Division of Rheumatology, The Zablocki VA Medical Center and the Medical College of Wisconsin, 5000 W National Avenue, Milwaukee, WI 53295 1000, USA
    Front Biosci 9:3257-61. 2004
    ..Transglutaminase (Tgase) enzymes have been implicated in pathologic mineralization in cartilage; yet, definitive studies linking Tgase ..
  86. ncbi Identification of a novel recognition sequence for fibronectin within the NH2-terminal beta-sandwich domain of tissue transglutaminase
    Jun Hang
    Department of Biochemistry and Molecular Biology and Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 280:23675-83. 2005
    ..Substitution of individual domains of tissue transglutaminase with those from homologous factor XIIIA showed that the major fibronectin-binding site is present within the first beta-sandwich domain of the protein...
  87. ncbi Analytical quantification of the inflammatory cell infiltrate and CD95R expression during treatment of drug-induced toxic epidermal necrolysis
    Philippe Paquet
    Department of Dermatopathology, University Hospital of Liege, CHU Sart Tilman, 4000, Liege, Belgium
    Arch Dermatol Res 297:266-73. 2005
    ..using antibodies directed to CD68 antigen (macrophages), CD45R0 antigen (activated T lymphocytes), Factor XIIIa (dermal dendrocytes) and the CD95 receptor (apoptosis marker)...
  88. ncbi Incidental calcifying fibrous tumor of the stomach presenting as a polyp
    Gulsum Ozlem Elpek
    Department of Pathology, Akdeniz University Medical School, Akdeniz, Antalya, Turkey
    Pathol Int 56:227-31. 2006
    ..The characteristic histopathological features and the presence of spindle cells that express factor XIIIa allowed a diagnosis of CFT to be made...
  89. ncbi Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes
    Liselotte S Ebbesen
    Clinical Institute, University Hospital of Aarhus, Skejby Sygehus, Brendstrupgaardsvej, Denmark
    Blood Coagul Fibrinolysis 17:293-301. 2006
    ..b>Coagulation factor XIIIa was upregulated and may contribute in increasing the firmness of the formed clot...
  90. ncbi Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer
    Gaynor Davies
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom
    J Exp Ther Oncol 6:257-64. 2007
    Prostate transglutaminase (TGase-4), has been identified as a TGase that has a pattern of prostate specific expression...
  91. ncbi Changes in hemostatic parameters after intranasal administration of peptide Pro-Gly-Pro
    L A Lyapina
    Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University
    Bull Exp Biol Med 144:491-3. 2007
    ..activity, and tissue plasminogen activator activity increased, while platelet aggregation and activity of factor XIIIa in rat blood plasma decreased over 3 h after single intranasal administration of proline-containing peptide Pro-..
  92. doi Environmental effects on transglutaminase production and cell sporulation in submerged cultivation of Bacillus circulans
    Claucia Fernanda Volken de Souza
    Food Science and Technology Institute, Federal University of Rio Grande do Sul, Av Bento Goncalves, 9500, PO Box 15090, ZIP 91501 970 Porto Alegre, RS, Brazil
    Appl Biochem Biotechnol 158:302-12. 2009
    ..of a newly isolated strain of Bacillus circulans from the Amazon and their correlations with transglutaminase (TGase) production and cell sporulation were investigated...
  93. pmc Addition of a sequence from alpha2-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis
    William P Sheffield
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    BMC Biotechnol 9:15. 2009
    ..The plasma protein alpha2-antiplasmin (alpha2AP) is cross-linked to fibrin in blood clots by the transglutaminase factor XIIIa, and in that location retards clot lysis...
  94. doi Development of an isoenzyme-specific colorimetric assay for tissue transglutaminase 2 cross-linking activity
    Mileidys Perez Alea
    CovalAb S A R L, Research Department, 11 Avenue Albert Einstein, 69100 Villeurbanne, Lyon, France
    Anal Biochem 389:150-6. 2009
    Tissue transglutaminase (TGase 2) belongs to the multigene transglutaminase family of Ca2+-dependent protein cross-linking enzymes...
  95. doi Acral self-healing collodion baby: report of a new clinical phenotype caused by a novel TGM1 mutation
    J Mazereeuw-Hautier
    Department of Dermatology, CHU Purpan, Toulouse 31024, France
    Br J Dermatol 161:456-63. 2009
    ..Arg396His. These predictions corroborated the analysis of recombinant transglutaminase (TGase)-1 proteins carrying the p.Val359Met and p.Arg396His mutations...
  96. ncbi Genetic variants of coagulation factor XIII and the risk of myocardial infarction in young women
    Bob Siegerink
    Br J Haematol 146:459-61. 2009
  97. pmc Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways
    Murugavel Ponnusamy
    Department of Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02903, USA
    Am J Physiol Renal Physiol 297:F1361-70. 2009
    Our recent studies showed that transglutaminase-1 (TGase-1) is uniquely expressed in mouse renal proximal tubular cells (RPTC) and mediates cell proliferation...
  98. doi Proteomic identification of pleckstrin-associated proteins in platelets: possible interactions with actin
    Akeel Baig
    Department of Pathology, McMaster University, Hamilton, ON, Canada
    Proteomics 9:4254-8. 2009
    ..and signal transduction (serum deprivation response protein, 17 beta-hydroxysteroid dehydrogenase 4 and factor XIIIA). Both platelet aggregation and/or secretion require actin polymerization...
  99. doi Lack of association between FXIII-Val34Leu, FVII-323 del/ins, and transforming growth factor beta1 (915G/T) gene polymorphisms and bronchopulmonary dysplasia: a single-center study
    Fatma Belgin Atac
    Department of Medical Biology and Genetics, Baskent University School of Medicine, Ankara, Turkey
    DNA Cell Biol 29:13-8. 2010
    ....
  100. doi Characterization of amine donor and acceptor sites for tissue type transglutaminase using a sequence from the C-terminus of human fibrillin-1 and the N-terminus of osteonectin
    Shih T Khew
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576
    Biomaterials 31:4600-8. 2010
    ..sequence also showed enzyme specificity for tissue TGase while no reaction was observed with plasma TGase (Factor XIIIa), consistent with its natural occurrence in vivo...
  101. pmc Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Nutr Metab Cardiovasc Dis 21:546-52. 2011
    ..We tested for the genetic association between AMI and single nucleotide polymorphisms (SNPs) in 24 loci, including GP6...

Research Grants37

  1. MOLECULAR DEFECTS OF FIBRIN STABILIZATION
    Laszlo Lorand; Fiscal Year: 2002
    ..Detection of circulating factor XIIIa activity as an indicator of thrombotic tendency. 4...
  2. COAGULATION OF BLOOD
    Laszlo Lorand; Fiscal Year: 1999
    ..studies on FXIIIA , 3) identification of donor sites in the 2 chains of human fibrin(ogen) reacting with Factor XIIIa, and 4) further identification of binding domains involved in the interaction of transglutaminase to human ..
  3. ROLE OF FACTOR XIII BINDING TO THE HEMOSTATIC PLUG
    Charles Greenberg; Fiscal Year: 1993
    ..and sequence the fibrin binding and platelet binding site(s) on the a-chain of FXIII; (2) to identify the Factor XIIIa binding site(is on fibrin and the platelet receptor for Factor XIIIA; (3) to study the physiologic consequences ..
  4. BIOLOGY OF FACTOR XIII
    JAN MC DONAGH; Fiscal Year: 1992
    ..Factor XIII is an important enzyme in the coagulation and fibrinolytic mechanisms. The function of factor XIIIa is to catalyze the formation of covalent bonds in fibrin and other substrates...
  5. Hormone Replacement Therapy and Prothrombotic Variants
    Bruce Psaty; Fiscal Year: 2005
    ..other procoagulant variants on the risk of cardiovascular events, and the main variants of interest are: (la) factor XIIIA Val34Leu; (ib) platelet glycoprotein (PGP) Jib Ile843Ser; (ic) PGP IIIa Leu33Pro; and (id) PGP Ia C807T...
  6. THROMBUS DETECTION USING FIBRIN-SPECIFIC ANTIBODIES
    Gary Matsueda; Fiscal Year: 1992
    ..we focus on the design and testing of various fibrin-like peptides corresponding to thrombin cleavage sites and Factor XIIIa cross-link sites, and describe plans for an improved screening strategy that uses fibrin miniclots rather than ..
  7. METAL DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 2002
    ..domains interact with factor Va we will use a fibronectin derived transamidation site in conjunction with factor XIIIa. A long-term goal of these studies is to determine, by X-ray crystallography, the structure of factor Va heavy ..
  8. BENJAMIN ALEXANDER RABY; Fiscal Year: 2015
    ..Desaturase locus (FADS1 &FADS2);the N-acetyl galactosaminidase (NAGA) locus, and the factor XIII A subunit (F13A1) locus...
  9. THE ROLE OF CONTRACTILE PROTEINS IN PLATELETS
    ELENA PUSZKIN; Fiscal Year: 1990
    ..and characterized in our laboratory from human platelets and smooth muscle tissue, that is different from factor XIIIa. The TGases also express proteolytic activity toward the cytoskeletal protein components that serve as suitable ..
  10. TRANSGLUTAMINASE INHIBITORS AND SOLID PHASE SUBSTRATES
    MARY TRAWICK; Fiscal Year: 1991
    To investigate the role of transglutaminase enzymes including human plasma Factor XIIIa in physiological processes such as blood clot stabilization, wound healing, cell proliferation, and skin formation, it is proposed that a series of ..
  11. Chi Huey Wong; Fiscal Year: 2014
    ..Transglycosylase (TGase) is the enzyme responsible for assembling the carbohydrate backbone of the bacterial cell wall: it is essential, ..
  12. Transglutaminase 2 S-Nitrosylation: Role in Age-Related Vascular Stiffness
    Dan E Berkowitz; Fiscal Year: 2013
    ..Furthermore, using TG2-/- mice, we show that TG2 is the primary TGase mediating stiffness of conduit arteries, and that it is regulated by endothelium-derived NO...
  13. Gary E Gibson; Fiscal Year: 2016
    ..mitochondrial enzyme a- ketoglutarate dehydrogenase complex (KGHDC) and an increased activity of transglutaminase (TGase)...
  14. BARRY FANBURG; Fiscal Year: 2015
    ..This enhanced serotonylation of SMC protein, occurring through the tissue enzyme transglutaminase (TGase), is influenced by the PDGF receptor and possibly other cell surface receptors that have been associated with PH...
  15. Ann K Rosenthal; Fiscal Year: 2014
    ..Exposure of normal articular chondrocytes to exogenous transglutaminase (Tgase) enzymes promotes chondrocyte hypertrophy in an integrin-dependent manner...
  16. Thomas Delong; Fiscal Year: 2014
    ..of ChgA-derived peptides can be increased significantly upon treatment with the enzyme tissue transglutaminase (TGase)...
  17. IDENTIFY A MAJOR GENE RESPONSIBLE FOR CLEFTING
    DAVID BIXLER; Fiscal Year: 1992
    ..genes in the mouse and (2) reports in humans suggesting linkage between known markers and a cleft phenotype (HLA, F13A, etc.) and chromosome abnormalities (deletion syndromes) which may pinpoint the gene...
  18. G PROTEIN AND PHOSPHOLIPASE C IN HORMONE SIGNALING
    Mie Jae Im; Fiscal Year: 2001
    ..Our recent studies revealed that Galphah is a multifunctional enzyme Known as tissue type transglutaminase (TGase II). Thus, Galphah possesses two important biological functions the GTPase and transglutaminase activities...
  19. EPIDERMAL TRANS-ACTING FACTORS IN SKIN DEVELOPMENT
    Renata Polakowska; Fiscal Year: 1993
    ..4) Determine whether epidermal transglutaminase (TGase I) is regulated by the same factor(s) and whether the synthesis and activity of the trans-acting factor(s) is ..
  20. MECHANISM OF ACTIVATION OF LATENT TGF BETA BY VASCULAR E
    Daniel Rifkin; Fiscal Year: 2000
    ..also requires the action of urokinase type plasminogen activator (uPA), plasmin, tissue type II transglutaminase (TGase), interaction of the complex with the cell surface mannose 6- phosphate/IGF-II receptor (M6P/IGF-IIr), and active ..
  21. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
    ..To test the hypothesis, we will 1) determine if the El^E4 protein is a TGase substrate or an inhibitor of these enzymes; 2) analyze the effects of El^E4 proteins on the composition and ..
  22. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2007
    ..Articular cartilage contains two Tgase enzymes, type II Tgase and Factor XIIIA (FXIIIA)...
  23. Matrix proteins promote matrix vesicle mineralization
    Ann Rosenthal; Fiscal Year: 2007
    ..The ultimate goal of this work is to understand the pathogenesis of calcium crystal formation in articular cartilage, so that specific therapies for this disabling disease can be designed. ..
  24. Admixture Mapping of Sarcoidosis Genes in African American
    Benjamin Rybicki; Fiscal Year: 2007
    ..Our proposed study has the potential to uncover genes of modest effect not easily detectable by linkage and may in some instances actually be more statistically powerful than traditional case-control association methods. ..
  25. ROLE OF PRE FIBRILLAR AMYLOID IN ALZHEIMER'S DISEASE
    Dean Hartley; Fiscal Year: 2002
    ....
  26. HEMIDESMOSOMAL PROTEIN LINKAGE MAP BY TWO-HYBRID SYSTEM
    Sirpa Aho; Fiscal Year: 2002
    ..abstract_text> ..
  27. GENETICS OF THE METABOLIC SYNDROME IN JAPANESE AMERICANS
    Melissa Austin; Fiscal Year: 2002
    ....
  28. SIGNAL TRANSDUCTION SYSTEMS IN ALZHEIMERS DISEASE
    Gary Gibson; Fiscal Year: 2003
    ..abstract_text> ..
  29. Mitochondiral enzymes/oxidative stress in Alzheimer's
    Gary Gibson; Fiscal Year: 2004
    ..These models will also provide systems to test the efficacy of approaches to limit or reverse the changes in mitochondria. ..
  30. Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & Colo
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2010
    ..We expect findings from this work to guide the development of future preventive, early detection and prognostic strategies ..
  31. Regulation of cAMP production by tissue transglutaminase
    Janusz Tucholski; Fiscal Year: 2005
    ..The results of these studies will provide important new information on the function of tTG in neurons and provide the basis for an R01 application. ..
  32. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2008
    ..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent,PTS. ..
  33. A Comprehensive Analysis of Genetic Variation in DNA Repair Genes in Relation to
    Christopher Haiman; Fiscal Year: 2007
    ..The ability to accurately identify high-risk sub-groups may have profound implications on endometrial cancer prevention as well as advance research aimed at targeted drug development. [unreadable] [unreadable] [unreadable]..
  34. AGE/NUTRITION/GENES IN MODELS OF PSYCHIATRIC DISORDERS
    Gary Gibson; Fiscal Year: 2007
    ..An understanding of these mechanisms will likely suggest new ways to overcome the consequences of the mild, chronic impairment of oxidative metabolism that accompanies numerous age-related neurodegenerative disorders. ..
  35. Pilot Study of Pancreas Cancer & Diabetes Genes in CARET
    Melissa Austin; Fiscal Year: 2006
    ..The results may facilitate translational studies of early detection and prevention of pancreatic cancer, especially among patients diagnosed with diabetes. [unreadable] [unreadable]..
  36. Beta-Amyloid Protofibrils Cause AD Neuronal Dysfunction
    Dean Hartley; Fiscal Year: 2006
    ..abstract_text> ..

Patents1

  1. Production of factor XIIIa by gene technology
    Patent Number: EP0236978-A2; Date:1987-09-16