Genomes and Genes
Gene Symbol: ezrin
Alias: CVIL, CVL, HEL-S-105, VIL2, ezrin, cytovillin 2, epididymis secretory protein Li 105, p81, villin 2 (ezrin)
Publications226 found, 100 shown here
- Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding siteR Gary
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
Mol Biol Cell 6:1061-75. 1995b>Ezrin is a membrane-cytoskeletal linking protein that is concentrated in actin-rich surface structures. It is closely related to the microvillar proteins radixin and moesin and to the tumor suppressor merlin/schwannomin...
- Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulatorsYanlin Yu
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 10:175-81. 2004..Subsequent in vivo functional studies revealed that the actin filament-plasma membrane linker ezrin (encoded by Vil2) and the homeodomain-containing transcription factor Six-1 (sine oculis-related homeobox-1 ..
- Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytesMarta Barrero-Villar
Servicio de Inmunologia, Hospital Universitario de la Princesa, 28006 Madrid, Spain
J Cell Sci 122:103-13. 2009..lymphocytes, we have investigated whether HIV-1 Env might promote viral entry and infection by activating ERM (ezrin-radixin-moesin) proteins to regulate F-actin reorganization and CD4/CXCR4 co-clustering...
- Prognostic implication of ezrin expression in esophageal squamous cell carcinomaJian Jun Xie
Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People s Republic of China
J Surg Oncol 104:538-43. 2011b>Ezrin, a member of the ezrin-radixin-moesin family, was implicated in tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including esophageal squamous cell carcinoma (ESCC)...
- Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family memberLeena Heiska
Department of Pathology, Neuroscience Program, Biomedicum Helsinki, University of Helsinki and Helsinki University Hospital, FIN 00014 Helsinki, Finland
J Biol Chem 280:10244-52. 2005b>Ezrin, a linker between plasma membrane and actin cytoskeleton possesses morphogenic properties and can promote dissemination of tumor cells...
- LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylationNatalya V Belkina
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:4707-12. 2009ERM (ezrin-radixin-moesin) proteins mediate linkage of actin cytoskeleton to plasma membrane in many cells...
- Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomasWen Hui Weng
Department of Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
Clin Cancer Res 11:6198-204. 2005b>Ezrin is a cytoskeleton linker protein that is actively involved in regulating the growth and metastatic capacity of cancer cells. It has recently been reported to be involved in dissemination of pediatric soft tissue sarcoma (STS).
- Ezrin mutants affecting dimerization and activationDavid N Chambers
Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
Biochemistry 44:3926-32. 2005ERM (ezrin/radixin/moesin) proteins provide a regulated linkage between membrane-associated proteins and the actin cytoskeleton...
- Ezrin is associated with gastric cancer progression and prognosisLi Li
Department of Pathology, Zhejiang Provincial People s Hospital, Hangzhou 310014, People s Republic of China
Pathol Oncol Res 17:909-15. 2011To investigat the clinical significance of Ezrin in the development and progression of gastric cancer. Immunohistochemistry was employed to analyze Ezrin expression in 436 clinicopathologically characterized gastric cancer cases...
- Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinomaYou yuan Wang
Department of Oral and Maxillofacial Surgery, Sun Yat sen Memorial Hospital No 2 Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:96-104. 2011The aim of this study was to investigate the relationship between membrane cytoskeleton linker protein Ezrin and CD44v6, iNOS, Ki-67, and clinicopathologic characteristics, and the prognostic significance of Ezrin expression in salivary ..
- Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcomaShen Xu-Dong
Department of Oncology, Shanghai 6th People s Hospital, Shanghai Jiao Tong University, Shanghai, China
Clin Invest Med 32:E180-8. 2009To determine the prognostic value of the expression of Ezrin, CD44 and Six1 genes in osteosarcoma tissues of Chinese patients.
- Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinomaYong Chen
Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shanxi, P R China
Cancer Res 71:1721-9. 2011..In particular, we found that Thr567 hyperphosphorylation of the cytoskeletal protein ezrin was tightly correlated to an invasive phenotype of clinical hepatocellular carcinomas and to poor outcomes in ..
- The ezrin metastatic phenotype is associated with the initiation of protein translationJoseph W Briggs
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Neoplasia 14:297-310. 2012We previously associated the cytoskeleton linker protein, Ezrin, with the metastatic phenotype of pediatric sarcomas, including osteosarcoma and rhabdomyosarcoma...
- The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasisChand Khanna
Pediatric Oncology Branch and Tissue Array Project Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 10:182-6. 2004..From this genomic data, we selected ezrin for further study based on its role in physically and functionally connecting the actin cytoskeleton to the cell ..
- Src-dependent ezrin phosphorylation in adhesion-mediated signalingJ Srivastava
Morphogenèse et Signalisation Cellulaires, UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
Mol Biol Cell 16:1481-90. 2005In addition to providing a regulated linkage between the membrane and the actin cytoskeleton, ezrin participates in signal transduction pathways...
- Knockdown of ezrin via RNA interference suppresses Helicobacter pylori-enhanced invasion of gastric cancer cellsLi lin Fan
Department of Gastroenterology, Southwest Hospital, Chongqing, China
Cancer Biol Ther 11:746-52. 2011..b>Ezrin, a membrane cytoskeletal crosslinker protein, is well documented to regulate cell adhesion and cell motility...
- Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motilityT Ng
Richard Dimbleby Department of Cancer Research, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
EMBO J 20:2723-41. 2001..This PKC-driven migratory response directly correlates with increased C-terminal threonine phosphorylation of ezrin/moesin/radixin (ERM) at the wound edge...
- The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domainCasey M Finnerty
Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
J Cell Sci 117:1547-52. 2004Members of the ezrin-radixin-moesin (ERM) protein family serve as regulated microfilament-membrane crosslinking proteins that, upon activation, bind the scaffolding protein ERM-phosphoprotein of 50 kDa (EBP50). Here we report a 3...
- The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylationFrancesca Di Sole
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8885, USA
J Am Soc Nephrol 20:1776-86. 2009..protein-1 (CHP1) in opossum kidney cells increased NHE3 transport activity, surface protein abundance, and ezrin phosphorylation. CHP1 knockdown by small interfering RNA had the opposite effects...
- Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9Beibei Zhou
Department of Immunology, College of Basic Medical Science, Wuhan University, Wuhan, Hubei, China
Leuk Res 34:769-76. 2010Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor ..
- 17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrinShuHui Zheng
Department of Physiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
PLoS ONE 6:e22439. 2011..However, the detailed mechanism remains largely unknown. The actin binding protein ezrin is a key component in tumor metastasis and its over-expression is positively correlated to the poor outcome of ..
- Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cellsQingchang Li
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China
Tumour Biol 33:1493-504. 2012b>Ezrin, one of the ezrin-radixin-moesin proteins, is involved in the formation of cell membrane processes such as lamellipodia and filopodia and acts as a membrane-cytoskeleton linker...
- Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivityChristelle Brégnard
Hopital Necker Enfants Malades, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
J Virol 87:3729-40. 2013..We observe that glucosidase II is enriched in WT virions, whereas Ezrin, ALG-2, CD81, and EHD4 are enriched in nef-deleted virions...
- PACE-1, a novel protein that interacts with the C-terminal domain of ezrinAlexandra Sullivan
Ludwig Institute for Cancer Research, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
Exp Cell Res 284:224-38. 2003The ERM proteins (ezrin, radixin, moesin) together with merlin comprise a subgroup of the band 4.1 superfamily...
- Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cellsMarylise Hebert
Institut National de la Santé et de la Recherche Médicale U749, Faculte de Pharmacie, Chatenay Malabry, France
J Immunol 181:5963-73. 2008..It has been shown that ezrin, a member of the ERM (ezrin-radixin-moesin) protein family can link Fas to the actin cytoskeleton...
- cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1K L Gould
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92138
EMBO J 8:4133-42. 1989b>Ezrin is a component of the microvilli of intestinal epithelial cells and serves as a major cytoplasmic substrate for certain protein-tyrosine kinases...
- A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motilityJames W Legg
Department of Biological Sciences, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, Imperial College Road, London SW7 2AZ, UK
Nat Cell Biol 4:399-407. 2002..chemotaxis assays we show that phosphorylation of Ser291 modulates the interaction between CD44 and the cytoskeletal linker protein ezrin in vivo, and that this phosphorylation is critical for CD44-dependent directional cell motility.
- Molecular analysis of microscopic ezrin dynamics by two-photon FRAPSylvie Coscoy
Laboratoires de Physico Chimie, Unité Mixte de Recherche 168 and Morphogenèse et Signalisation Cellulaires, Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
Proc Natl Acad Sci U S A 99:12813-8. 2002b>Ezrin plays a key role in coupling signal transduction to cortical cell organization...
- Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactionsWilliam James Smith
Department of Chemistry, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 278:4949-56. 2003b>Ezrin is a member of the ERM (ezrin, radixin, moesin) family of proteins that cross-link the actin cytoskeleton to the plasma membrane and also may function in signaling cascades that regulate the assembly of actin stress fibers...
- Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cellsMichelle L Janket
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Virus Res 126:76-85. 2007..NHE1 downregulation further led to acidification of cells and was directly correlated with loss of ezrin, radixin and moesin (ERM) protein complex and decreased AKT phosphorylation...
- Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42Soren Prag
Richard Dimbleby Department of Cancer Research, King s College London, Guy s Medical School Campus, London SE1 1UL, United Kingdom
Mol Biol Cell 18:2935-48. 2007..Here, we describe a novel role of the actin-binding ezrin/radixin/moesin (ERM)-protein ezrin to be involved in recruiting Cdc42, but not Rac1, to lipid raft microdomains, ..
- Properties of an ezrin mutant defective in F-actin bindingHenri S Saleh
Leibniz Institute of Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
J Mol Biol 385:1015-31. 2009b>Ezrin, radixin and moesin are a family of proteins that provide a link between the plasma membrane and the cortical actin cytoskeleton...
- Moesin: a member of the protein 4.1-talin-ezrin family of proteinsW T Lankes
Department of Pathology, Stanford University School of Medicine, CA 94305
Proc Natl Acad Sci U S A 88:8297-301. 1991..In addition, the protein shows significant sequence identity (72%) to ezrin (cytovillin, p81), as well as similarity to protein 4.1 and talin...
- Cytoskeletal proteins inside human immunodeficiency virus type 1 virionsD E Ott
AIDS Vaccine Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
J Virol 70:7734-43. 1996..in virions at different concentrations relative to the molar level of Gag: actin (approximately 10 to 15%), ezrin and moesin (approximately 2%), and cofilin (approximately 2 to 10%)...
- Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G proteinK Takahashi
Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan
J Biol Chem 272:23371-5. 1997..We have reported that the Rho subfamily members regulate the ezrin/radixin/moesin (ERM)-CD44 system, implicated in reorganization of actin filaments...
- NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrinC H Yun
Department of Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 273:25856-63. 1998..As shown earlier for the human homolog of NHERF, we also found that the cytoskeletal protein ezrin binds to the carboxyl-terminal domain of E3KARP...
- The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assemblyP Matarrese
Department of Ultrastructures, Instituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
Cell Death Differ 7:25-36. 2000..e. by inducing anoikis-resistance. These particular effects of vpr might enhance the homing, spreading and survival of the infected lymphocytes, thus contributing to virus persistence in the course of acute HIV-1 infection...
- Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cellsJ L Alonso-Lebrero
Servicio de Inmunologia, Hospital de la Princesa, Madrid, Spain Northwestern University Medical School, Chicago, IL, USA
Blood 95:2413-9. 2000..Bands of 78- and 81-kd were identified as moesin and ezrin by Western blot analysis...
- CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathwayS Parlato
Laboratories of Virology, Istituto Superiore di Sanità Viale Regina Elena 299, 00161 Rome, Italy
EMBO J 19:5123-34. 2000..to CD95-mediated apoptosis, exhibit a constitutive polarized morphology, and that CD95 colocalizes with ezrin at the site of cellular polarization...
- Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytesOlga Barreiro
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
J Cell Biol 157:1233-45. 2002b>Ezrin, radixin, and moesin (ERM) regulate cortical morphogenesis and cell adhesion by connecting membrane adhesion receptors to the actin-based cytoskeleton...
- ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1Ana Urzainqui
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
Immunity 17:401-12. 2002..This association is mediated by the actin-linking proteins moesin and ezrin, which directly interact with Syk in an ITAM-dependent manner...
- The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survivalKaren L Wu
Department of Medicine, Rammelkamp Center for Research, MetroHealth Medical Center Campus, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
J Biol Chem 279:26280-6. 2004..In addition to mediating Na(+)/H(+) transport, NHE1 interacts with ezrin/radixin/moesin (ERM), which tethers NHE1 to cortical actin cytoskeleton to regulate cell shape, adhesion, motility,..
- Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tetheringAleksandar Ivetic
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS United Kingdom
J Biol Chem 279:33263-72. 2004..We have previously identified ezrin and moesin as novel binding partners of the 17-amino acid L-selectin tail, but the biological role of this ..
- Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell deathP Matarrese
Section of Cell Aging and Degeneration, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
Cell Death Differ 12:932-41. 2005..The microfilament system seems thus to be a sort of cytoplasmic supervisor of the viral particle, the host cell and the bystander cell's very fate...
- Ezrin expression in prostate cancer and benign prostatic tissueAlexander Valdman
Department of Surgical Science, Section of Urology, Karolinska Institute, Stockholm, Sweden
Eur Urol 48:852-7. 2005The membrane-linking protein ezrin is highly expressed in several types of human cancers and correlations between its immunoreactivity and histopathological data as well as patient outcome have previously been shown...
- Androgen induction of prostate cancer cell invasion is mediated by ezrinYin Choy Chuan
Department of Molecular Medicine and Surgery, Section of Experimental Geriatrics, Karolinska Institute, Neurotec, Stockholm, Sweden
J Biol Chem 281:29938-48. 2006b>Ezrin is a key signaling molecule that regulates cell survival, adhesion migration, and invasion...
- The CD44 standard/ezrin complex regulates Fas-mediated apoptosis in Jurkat cellsAinhoa Mielgo
Institute of Medical Microbiology, Department of Clinical and Biological Sciences, University of Basel, Petersplatz 10, 4003 Basel, Switzerland
Apoptosis 12:2051-61. 2007..CD44 is a binding partner for the membrane-cytoskeleton cross-linker protein ezrin. In this study, we demonstrate that only CD44 standard (CD44s) colocalizes and interacts with the actin cross-..
- Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinomaChun Nan Yeh
Department of Surgery, Chang Gung Memorial Hospital Chang Gung University, Taoyuan, Taiwan, ROC
BMC Cancer 9:233. 2009..Only 5% of the general population is seronegative for all hepatititis B virus (HBV) markers. This is the first study to determine the role of ezrin upon HBV HCC cell and patients with HBV HCC undergoing hepatectomy
- Ezrin overexpression in gastrointestinal stromal tumors: an independent adverse prognosticator associated with the non-gastric locationYu Ching Wei
Department of Pathology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Mod Pathol 22:1351-60. 2009b>Ezrin, a member of the ezrin-radixin-moesin family, acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-mediated signaling...
- Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphateL Heiska
Department of Pathology, University of Helsinki, Haartman Institute, 00014 Helsinki, Finland
J Biol Chem 273:21893-900. 1998b>Ezrin is a cytoplasmic linker molecule between plasma membrane components and the actin-containing cytoskeleton. We studied whether ezrin is associated with intercellular adhesion molecule (ICAM)-1, -2, and -3...
- Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpainA Shcherbina
The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
FEBS Lett 443:31-6. 1999The ERM proteins, ezrin, radixin and moesin, provide regulated linkage of the cytoskeleton with the plasma membrane, particularly in cell surface projections...
- Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilliM Berryman
Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
Mol Biol Cell 11:1509-21. 2000..as a component of a multimeric complex consisting of several known cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1...
- Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenesC Tran Quang
Transcription Laboratory, Room 528, Imperial Cancer Research Fund Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO J 19:4565-76. 2000..We investigated the role of the cytoskeletal linker protein ezrin in this process...
- Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARPD Reczek
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
J Cell Biol 153:191-206. 2001..EPI64 colocalizes with EBP50 and ezrin in syncytiotrophoblast and cultured cell microvilli, and this localization in cultured cells is abolished by ..
- The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not EzrinAleksandar Ivetic
Divisions of Cellular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
J Biol Chem 277:2321-9. 2002..By using this approach, members of the Ezrin-Radixin-Moesin family of proteins were found to interact specifically with the cytoplasmic tail of L-selectin...
- A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targetingJuan M Serrador
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid 28006, Spain
J Biol Chem 277:10400-9. 2002..We have investigated the interaction between ICAM-3 and ezrin/radixin/moesin (ERM) proteins and its role in LFA-1-induced cell-cell interactions and membrane positioning of ..
- Identification of a novel Ezrin-binding site in syndecan-2 cytoplasmic domainFrancesc Granes
Department of Cellular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
FEBS Lett 547:212-6. 2003ERM (Ezrin/Radixin/Moesin) proteins are crosslinkers between plasma membrane proteins and the actin cytoskeleton, thereby involved in the formation of cell adhesion sites...
- A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cellsBeate K Straub
Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Cell Sci 116:4985-95. 2003..The other complex contains ezrin, periplakin, periaxin and desmoyokin (and so is called the EPPD complex), usually together with moesin, spectrin(s)..
- G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeletonSarah H Cant
MRC Laboratory for Molecular and Cellular Biology and Department of Pharmacology, University College London, London, WC1E 6BT United Kingdom
Mol Biol Cell 16:3088-99. 2005..Here, we identify ezrin as a novel non-GPCR substrate of GRK2...
- Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recyclingLaura Stanasila
Département de Pharmacologie et de Toxicologie, Faculté de Biologie et de Médecine, Lausanne, Switzerland
J Biol Chem 281:4354-63. 2006Using the yeast two-hybrid system, we identified ezrin as a protein interacting with the C-tail of the alpha1b-adrenergic receptor (AR)...
- Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomasDavid Sarrio
Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
Breast Cancer Res Treat 98:71-9. 2006The membrane-cytoskeleton crosslinker ezrin is associated with malignant progression and metastasis in human neoplasias...
- Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomasMartin Köbel
Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
Mod Pathol 19:581-7. 2006As a cortical cytoskeletal protein, ezrin adapts the cytoplasmic tail of CD44 to the actin-based cytoskeleton and is functionally involved in migration and adhesion that are prerequisites for metastasis...
- Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastasesXiyun Deng
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Clin Exp Metastasis 24:107-19. 2007..Five of the nine up-regulated genes, including caveolin 1, CD44, EphB2, ezrin, and Parathyroid hormone-related protein (PTHrP), and one down-regulated gene, SLPI, were further confirmed by ..
- Expression of the cytoskeleton linker protein ezrin in human cancersBenjamin Bruce
Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Clin Exp Metastasis 24:69-78. 2007Expression of the metastasis-associated protein, ezrin, in over 5,000 human cancers and normal tissues was analyzed using tissue microarray immunohistochemistry...
- Association of ezrin expression in intestinal and diffuse gastric carcinoma with clinicopathological parameters and tumor typeNebil Bal
Baskent University, Adana Research and Medical Center, Pathology Department, Yuregir, Adana 01250, Turkey
World J Gastroenterol 13:3726-9. 2007To investigate the correlation between ezrin expression and types of gastric carcinoma and clinico-pathological variables.
- Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infectionYoshinao Kubo
Department of AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, National Institute of Infectious Diseases, Tokyo, Japan
Virology 375:130-40. 2008b>Ezrin, radixin, and moesin (ERM) proteins supply functional linkage between integral membrane proteins and cytoskeleton in mammalian cells to regulate membrane protein dynamisms and cytoskeleton rearrangement...
- Ezrin is a key element in the human vaginaA Fadiel
Department of Obstetrics and Gynecology, New York University, 550 First Avenue, TH528, New York, NY 10016, United States
Maturitas 60:31-41. 2008..This integration is the domain of cytoskeletal proteins including the MERM protein family (moesin-ezrin-radixin-Merlin)...
- The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKCL Ren
Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Oncogene 28:792-802. 2009b>Ezrin is a member of the ERM (ezrin, radixin, moesin) protein family and links F-actin to the cell membrane following phosphorylation...
- Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cellsJian Jun Xie
Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People s Republic of China
Int J Cancer 124:2549-58. 2009b>Ezrin, which crosslinks the cytoskeleton and plasma membrane, is involved in the growth and metastatic potential of cancer cells...
- Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migrationK Endo
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
Oncogene 28:1725-35. 2009..Recently, the membrane crosslinker protein, ezrin, has been implicated in tumor cell metastasis and malignant progression...
- Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jawHye Rim Park
Department of Pathology College of Medicine, Hallym University, Anyang, Korea
Tumori 95:81-6. 2009b>Ezrin is a membrane-cytoskeleton linker protein involved in regulation of the growth and metastatic behavior of cancer cells. Metastatic tumor antigen (MTA) is a potential metastasis-associated protein...
- Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1Jianquan Li
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
J Mol Biol 392:166-80. 2009..This CT domain binds to ezrin, which, in turn, interacts with cytosekeletal actin...
- Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapseRémi Lasserre
Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
EMBO J 29:2301-14. 2010..We show here that the membrane-microfilament linker ezrin has an important function in microcluster dynamics and in TCR signalling through its ability to set the ..
- Prognostic implication of ezrin overexpression in myxofibrosarcomasHsuan Ying Huang
Department of Pathology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung County 833, Taiwan
Ann Surg Oncol 17:3212-9. 2010The bases of tumorigenesis, progression, and metastasis remain obscure in myxofibrosarcoma. As a member of ezrin-radixin-moesin family, ezrin acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-..
- Expression change of ezrin as a prognostic factor in primary osteosarcomaYao Fei Wang
Department of Orthopaedic Surgery, Musculoskeletal Tumor Center, the First Affiliated Hospital of Sun Yat Sen University, No 58 Zhongshan 2nd road, 510080 Guangzhou, Guangdong, China
Med Oncol 28:S636-43. 2011Osteosarcoma is a life-threatening malignancy that most often occurs in teenagers. Ezrin is a cytoskeleton linker protein that is actively involved in the metastatic capacity of cancer cells...
- Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stressMiguel Fidalgo
Department of Physiology and Centro Singular de Medicina Molecular y Enfermedades Crónicas CIMUS, University of Santiago de Compostela, Spain
J Biol Chem 287:11556-65. 2012..that it is involved in a novel response to oxidative stress that results in phosphorylation and activation of the ezrin/radixin/moesin (ERM) family of proteins...
- Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohortsGustav Andersson
Department of Clinical Sciences, Oncology and Pathology, Lund University, Skane University Hospital, Lund 221 85, Sweden
BMC Urol 14:36. 2014Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcinoma of the bladder treated ..
- Ezrin has properties to self-associate at the plasma membraneC Andreoli
CNRS URA 1856, Universite Montpellier II, Département Biologie Santé, France
J Cell Sci 107:2509-21. 1994b>Ezrin, a member of a family of proteins involved in the interaction of the microfilament cytoskeleton with the plasma membrane, plays a role in membrane translocation in gastric parietal cells (Hanzel, D., Reggio, H., Bretscher, A...
- Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein familyO Turunen
Haartman Institute, Department of Virology, Helsinki University, Finland
J Cell Biol 126:1445-53. 1994b>Ezrin, previously also known as cytovillin, p81, and 80K, is a cytoplasmic protein enriched in microvilli and other cell surface structures. Ezrin is postulated to have a membrane-cytoskeleton linker role...
- Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteinsR Gary
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
Proc Natl Acad Sci U S A 90:10846-50. 1993b>Ezrin and moesin are components of actin-rich cell surface structures that are thought to function as membrane-cytoskeletal linking proteins...
- Ezrin is a cyclic AMP-dependent protein kinase anchoring proteinD T Dransfield
Institute of Molecular Medicine and Genetics, Medical College of Georgia and the Augusta Veterans Affairs Medical Center, 30912, USA
EMBO J 16:35-43. 1997..The purified 78 kDa AKAP was recognized by monoclonal antibodies against ezrin, the canalicular actin-associated protein...
- Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin familyD Reczek
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
J Cell Biol 139:169-79. 1997Members of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linking proteins have NH2- and COOH-terminal domains that associate with the plasma membrane and the actin cytoskeleton, respectively...
- CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contactsJ M Serrador
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
Blood 91:4632-44. 1998..Immunofluorescence analysis showed that all three ezrin-radixin-moesin (ERM) actin-binding proteins localized in the uropod of both human T lymphoblasts stimulated with ..
- Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathwayA Gautreau
Laboratoire de Morphogenèse et Signalisation Cellulaires, Unite Mixte de Recherche, 144 Centre National de la Recherche Scientifique Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Proc Natl Acad Sci U S A 96:7300-5. 1999ERM (Ezrin-Radixin-Moesin) proteins function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains of the plasma membrane...
- Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-cateninS Hiscox
Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
J Cell Sci 112:3081-90. 1999b>Ezrin, radixin, moesin and merlin form a subfamily of conserved proteins in the band 4.1 superfamily. The function of these proteins is to link the plasma membrane to the actin cytoskeleton...
- The role of the CD44/ezrin complex in cancer metastasisTracey A Martin
Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, S Wales CF14 4XN, UK
Crit Rev Oncol Hematol 46:165-86. 2003..This molecule is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, ..
- Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcomaHye Rim Park
Department of Pathology, College of Medicine, Hallym University, Anyang, Republic of Korea
Pathol Res Pract 202:509-15. 2006b>Ezrin is a cytoskeleton linker protein that is actively involved in the regulation of growth and metastatic capacity of cancer cells...
- Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcomaStefano Ferrari
Chemotherapy Unit, Istituto Ortopedico Rizzoli, Bologna, Italy
Pediatr Blood Cancer 50:752-6. 2008b>Ezrin is a membrane-cytoskeleton linker protein involved in regulating growth and metastatic behaviour of cancer cells. The study evaluated ezrin expression and its prognostic value in patients with non-metastatic osteosarcoma.
- Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cellsQiong Li
Cancer Biology Research Center, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Anv, Wuhan, Hubei 430030, PR China
Cancer Lett 261:55-63. 2008b>Ezrin primarily acts as a linker between the plasma membrane and the cytoskeleton and is a key component in tumor metastasis...
- The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infectionJuliane Haedicke
Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland
J Virol 82:4665-70. 2008..Here, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia ..
- Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancerAdam Elzagheid
Department of Oncology and Radiotherapy, Turku University Hospital, FIN 20521 Turku, Finland
Hum Pathol 39:1737-43. 2008b>Ezrin is a membrane-cytoskeleton anchor, which, in experimental models, regulates tumor cell invasion and metastatic ability...
- Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cellsH M Kocher
Centre for Tumour Biology, Institute of Cancer and CR UK Clinical Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London, UK
Gut 58:271-84. 2009Pancreatic cancer is a highly invasive malignancy. Ezrin, a plasma membrane-cytoskeletal linker protein, is associated with the invasive behaviour of cancers...
- Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cellsShu Ying Gao
Department of Biochemistry and Molecular Biology, Shantou University, Shantou, China
J Biol Chem 284:7995-8004. 2009b>Ezrin, encoded by VIL2, is a membrane-cytoskeletal linker protein that has been suggested to be involved in tumorigenesis...
- Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complexJean Paul ten Klooster
Hubrecht Institute, KNAW and University Medical Centre, Utrecht, The Netherlands
Dev Cell 16:551-62. 2009..As an essential event in brush border formation, Mst4 phosphorylates the regulatory T567 residue of Ezrin. These data define a brush border induction pathway downstream of the Lkb1/Strad/Mo25 polarization complex, yet ..
- Ezrin is a negative regulator of death receptor-induced apoptosisW C Kuo
Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
Oncogene 29:1374-83. 2010b>Ezrin links cortical actin filaments with the cell membrane, and has a critical role in many membrane-initiated events...
- Ezrin mediates c-Myc actions in prostate cancer cell invasionY C Chuan
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
Oncogene 29:1531-42. 2010..We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens...
- Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinomaZhi qiang Ling
Department of Pathology, Shiga University of Medical Science, Shiga, Japan
Cancer Sci 101:624-30. 2010..Of the many genes identified, we detected an interesting ezrin amplicon that has been recently reported in human ESCC...
- A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organizationDavid P LaLonde
Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
Mol Biol Cell 21:1519-29. 2010PDZK1 and ezrin, radixin, moesin binding phosphoprotein 50 kDa (EBP50) are postsynaptic density 95/disc-large/zona occludens (PDZ)-domain-containing scaffolding proteins found in the apical microvilli of polarized epithelial cells...
- Ezrin promotes invasion and metastasis of pancreatic cancer cellsYunxiao Meng
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, 1 Shuai Fu Yuan Hu Tong, Beijing, China
J Transl Med 8:61. 2010..b>Ezrin plays important roles in cell motility, invasion and tumor progression, and it is especially crucial for ..
- Role for ezrin in breast cancer cell chemotaxis to CCL5Juanjuan Li
Department of Breast and Thyroid Gland Surgery of Renmin Hospital of Wuhan University, the First College of Clinical Medicine of Wuhan University, Wuhan, Hubei 430060, P R China
Oncol Rep 24:965-71. 2010This study was undertaken to observe the effects and the possible mechanism of membrane-cytoskeleton linker ezrin on the chemokine CC chemokine ligand 5 (CCL5)-induced invasive ability in human breast carcinoma MCF-7 cells...
- Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with rectal cancerEija A Korkeila
Department of Oncology and Radiotherapy, University of Turku, Turku University Hospital, Hämeentie 11, PB 52, FIN 20521 Turku, Finland
Hum Pathol 42:384-92. 2011The purpose of this study was to assess the value of ezrin expression as a predictor of disease outcome in rectal cancer treated by preoperative radio- or chemoradiotherapy...
- Effect of Lactobacillus on genital HIV-1 RNA and DNA shedding in womenJane E Hitti; Fiscal Year: 2010..We propose to evaluate this hypothesis using archived cervicovaginal lavage (CVL) and cervical cytobrush samples from parallel cohorts of HIV-1-infected women in the United States and Kenya...
- Anna Wald; Fiscal Year: 2016..factors MIP-1[unreadable], IL-1[unreadable], and IL-8, measured by Luminex assays in cervicovaginal lavage (CVL) samples from adolescent women before and after initiation of sexual activity, and after HSV-2 seroconversion...
- Genetic Risk Factors for Visceral LeishmaniasisMary E Wilson; Fiscal Year: 2013..provided by applicant): Three major worldwide foci of the fatal parasitic disease visceral leishmaniasis (cVL) occur in India, Sudan and Brazil...
- Leslie A Parker; Fiscal Year: 2016..parenteral nutrition associated liver disease (PNALD), poor growth, more hours requiring a central venous line (CVL), increased risk of late onset sepsis (LOS), prolonged hospitalization, as well as disturbances in gastrointestinal ..
- HIV Integrase as a Target for Topical MIcrobicide DevelopmentMary Klotman; Fiscal Year: 2009..rhesus macaque (RM) cervicovaginal explants along with a similar analysis of tissue and cervical vaginal lavage (CVL) fluid derived from in vivo RM studies in the R33 phase will validate the cervicovaginal explant model as a screen ..
- KIMBERLY POWERS; Fiscal Year: 2014..Currently, the US National HIV/AIDS Strategy recommends "community viral load" (CVL) as a metric for this purpose, and the US Centers for Disease Control and Prevention have issued guidance on the ..
- JOHN CHRISTIAN TILTON; Fiscal Year: 2016..2. Quantify bacterial species and metabolites present in cervicovaginal lavage (CVL) samples and correlate metabolites with specific species or groups of bacteria...
- Mark H Einstein; Fiscal Year: 2015..Female genital tract secretions will be collected by cervicovaginal lavage (CVL) at different times post-application and spiked with HPV pseudovirions in the absence and presence of seminal ..
- Novel Evaluation Methods for Multi-Level/Combination HIV Prevention InterventionsEDWIN DUNCAN CHARLEBOIS; Fiscal Year: 2013..However, such comprehensive methods do not exist. The recent development of the concept of Community Viral Load (CVL), presents a significant opportunity to evaluate T2 translational research (bedside-to-community) at the community ..
- The Role of Mucosal Immunity in the Risk of HIV-1 Acquisition During PregnancyBrenna L Anderson; Fiscal Year: 2013..The hypothesis to be tested is that the cervicovaginal lavage (CVL) of pregnant women will inhibit HIV infectivity to a lesser extent than that of non-pregnant women...
- RENOVATION OF NINTH FLOOR OF BURNETT-WOMACKWILLIAM ROPER; Fiscal Year: 2004..and bio-defense; three members of the Infectious Disease Center who have collaborative relationships with the CVl in order to provide the space they need to support their growing research preclinical programs in pathogens which ..
- MUCOSALLY DELIVERED DNA/MVA VACCINES IN A SHIV MODELThomas VanCott; Fiscal Year: 2004..Furthermore, the macaque CVL IgA responses were capable of neutralizing SHIV-89.6PD infection of cultures of dendritic cells and T cells in vivo...
- Recombinant CCR5 Inhibitors for Topical MicrobicidesDonald Mosier; Fiscal Year: 2007..and compare the stability of the molecules to low pH, high temperature, and exposure to cervicovaginal lavage (CVL) fluid...
- FLP-102: Rationally Engineered Antiviral ProteinOSMOND D CRUZ; Fiscal Year: 2003..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
- Vanadocenes as a New Class of Spermicidal DrugsOSMOND D CRUZ; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITYOSMOND D CRUZ; Fiscal Year: 2001..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
- Stampidine: A Novel Broad-Spectrum Anti-HIV MicrobicideOSMOND D CRUZ; Fiscal Year: 2005..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
- Phase II SBIR: WHI-07: A Novel Dual-Function MicrobicideOSMOND D CRUZ; Fiscal Year: 2005....
- METVAN: A Novel Anticancer AgentOSMOND D CRUZ; Fiscal Year: 2003..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
- PHI 346: A Novel Dual-Function MicrobicideOSMOND D CRUZ; Fiscal Year: 2003..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
- ANTI-HIV-1 ACTIVITY OF MANNAN-BINDING LECTINGregory Spear; Fiscal Year: 2003..3. Utilize inhibitors of glycosylation to enhance biological effects of MBL. Exarnine the interaction of MBL with anti-viral antibodies in mediating anti-viral effects. Deterrnine the interaction of HIV-1 with MBL in vivo. ..
- PHI-443: Novel Non-Spermicidal Anti-HIV MicrobicideOSMOND D CRUZ; Fiscal Year: 2003..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
- Randomized trial of HIV / STD prevention in Zimbabwean youthFrances Cowan; Fiscal Year: 2006..The most valid method will then be used in the final outcomes survey for the parent trial. [unreadable] [unreadable] [unreadable]..
- Trial of Vitamins in HIV Progression and TransmissionWafaie Fawzi; Fiscal Year: 2009..The study is a collaborative effort between Harvard School of Public Health and Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania. ..
- Trial of Vitamins among Children of HIV-infected MothersWafaie Fawzi; Fiscal Year: 2007..The study will be carried out as a collaborative effort between the Harvard School of Public Health and Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania. ..
- ANTIVIRAL THERAPY AND HIV IN THE GENITAL TRACT OF WOMENSusan Cu Uvin; Fiscal Year: 2007..We also propose to enroll women who have undergone total hysterectomy to assess HIV dynamics in the vagina. ..
- Partnership on Nutrition and HIV/AIDS Research in Tanza*Wafaie Fawzi; Fiscal Year: 2006..The program will be carried out as a collaborative effort between Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania and the Harvard School of Public Health, Boston, MA. ..
- HPV Induced Pathogenesis in Head and Neck CancerNICOLAS SCHLECHT; Fiscal Year: 2006..abstract_text> ..
- CCR5 and CXCR4 Binding Chemokines and Oral HIV InfectionGrace John Stewart; Fiscal Year: 2005..abstract_text> ..
- NUTRITION, IMMUNOLOGY, AND EPIDEMIOLOGY OF TBWafaie Fawzi; Fiscal Year: 2004..abstract_text> ..
- Epidemiology of HIV-1/HIV-2 Dual InfectionGeoffrey Gottlieb; Fiscal Year: 2005....
- Characterization of intestinal adenosine A2b receptorShanthi Sitaraman; Fiscal Year: 2004..Specific aim 3: We will study: i) the effect of IL-6 on degranulation of neutrophils. ..
- INTESTINAL ADENOSINE A2B RECEPTORShanthi Sitaraman; Fiscal Year: 2004..Third, I will study the role of adenosine receptor in the modulation and feedback regulation of neutrophil-epithelial interaction including transmigration and chemokine secretion. ..
- HIV PREVENTION TRIALS UNITWafaie Fawzi; Fiscal Year: 2004..S., the commitment of the authorities in Tanzania to HIV research, and the political stability in Tanzania, would make this collaboration a valuable addition to the HPTN. ..
- HIV-1 Specific Cytotoxic T Lymphocytes in BreastmilkGrace John Stewart; Fiscal Year: 2003..The resulting findings will be relevant to development of vaccines for prevention of mother-to-child transmission of HIV-1. ..
- A TRAIL OF MICRONUTRIENTS AND ADVERSE PREGNACY OUTCOMESWafaie Fawzi; Fiscal Year: 2003..To examine potential mechanisms of action of the supplements or dietary patterns and intake of individual nutrients, they will assess the following secondary outcomes among women: hemoglobin levels, T cell counts, and placental weight. ..
- PEDIATRIC ONCOLOGY GROUP STUDIESThomas McLean; Fiscal Year: 2002....
- Role of Clic in Epithelial MorphogenesisMark Berryman; Fiscal Year: 2008..The fruit fly will be used as a model system to understand how Clic works with other genes and proteins known to be important for cell shape and movement during embryonic development. [unreadable] [unreadable] [unreadable]..
- The Role of Connexin32 in the Pathogenesis of CMTXSteven Scherer; Fiscal Year: 2006....
- Axonal alterations in demyelinating diseasesSTEVEN SIMON SCHERER; Fiscal Year: 2011..Aim #3: What Na,K-ATPase isoforms are expressed by myelinated axons and demyelinated axons? we will localize alpha1-3 by immunoelectron microscopy in CMSand PNS myelinated axons, along with their beta subunits. ..