ezrin

Summary

Gene Symbol: ezrin
Description: ezrin
Alias: CVIL, CVL, HEL-S-105, VIL2, ezrin, cytovillin 2, epididymis secretory protein Li 105, p81, villin 2 (ezrin)
Species: human

Top Publications

  1. pmc Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 6:1061-75. 1995
  2. ncbi Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
    Yanlin Yu
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:175-81. 2004
  3. doi Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes
    Marta Barrero-Villar
    Servicio de Inmunologia, Hospital Universitario de la Princesa, 28006 Madrid, Spain
    J Cell Sci 122:103-13. 2009
  4. doi Prognostic implication of ezrin expression in esophageal squamous cell carcinoma
    Jian Jun Xie
    Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People s Republic of China
    J Surg Oncol 104:538-43. 2011
  5. ncbi Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member
    Leena Heiska
    Department of Pathology, Neuroscience Program, Biomedicum Helsinki, University of Helsinki and Helsinki University Hospital, FIN 00014 Helsinki, Finland
    J Biol Chem 280:10244-52. 2005
  6. pmc LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation
    Natalya V Belkina
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:4707-12. 2009
  7. ncbi Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas
    Wen Hui Weng
    Department of Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    Clin Cancer Res 11:6198-204. 2005
  8. ncbi Ezrin mutants affecting dimerization and activation
    David N Chambers
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 44:3926-32. 2005
  9. doi Ezrin is associated with gastric cancer progression and prognosis
    Li Li
    Department of Pathology, Zhejiang Provincial People s Hospital, Hangzhou 310014, People s Republic of China
    Pathol Oncol Res 17:909-15. 2011
  10. doi Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinoma
    You yuan Wang
    Department of Oral and Maxillofacial Surgery, Sun Yat sen Memorial Hospital No 2 Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:96-104. 2011

Research Grants

  1. Effect of Lactobacillus on genital HIV-1 RNA and DNA shedding in women
    Jane E Hitti; Fiscal Year: 2010
  2. Anna Wald; Fiscal Year: 2016
  3. Genetic Risk Factors for Visceral Leishmaniasis
    Mary E Wilson; Fiscal Year: 2013
  4. Leslie A Parker; Fiscal Year: 2016
  5. HIV Integrase as a Target for Topical MIcrobicide Development
    Mary Klotman; Fiscal Year: 2009
  6. KIMBERLY POWERS; Fiscal Year: 2014
  7. JOHN CHRISTIAN TILTON; Fiscal Year: 2016
  8. Mark H Einstein; Fiscal Year: 2015
  9. Novel Evaluation Methods for Multi-Level/Combination HIV Prevention Interventions
    EDWIN DUNCAN CHARLEBOIS; Fiscal Year: 2013
  10. The Role of Mucosal Immunity in the Risk of HIV-1 Acquisition During Pregnancy
    Brenna L Anderson; Fiscal Year: 2013

Detail Information

Publications226 found, 100 shown here

  1. pmc Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 6:1061-75. 1995
    b>Ezrin is a membrane-cytoskeletal linking protein that is concentrated in actin-rich surface structures. It is closely related to the microvillar proteins radixin and moesin and to the tumor suppressor merlin/schwannomin...
  2. ncbi Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
    Yanlin Yu
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:175-81. 2004
    ..Subsequent in vivo functional studies revealed that the actin filament-plasma membrane linker ezrin (encoded by Vil2) and the homeodomain-containing transcription factor Six-1 (sine oculis-related homeobox-1 ..
  3. doi Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes
    Marta Barrero-Villar
    Servicio de Inmunologia, Hospital Universitario de la Princesa, 28006 Madrid, Spain
    J Cell Sci 122:103-13. 2009
    ..lymphocytes, we have investigated whether HIV-1 Env might promote viral entry and infection by activating ERM (ezrin-radixin-moesin) proteins to regulate F-actin reorganization and CD4/CXCR4 co-clustering...
  4. doi Prognostic implication of ezrin expression in esophageal squamous cell carcinoma
    Jian Jun Xie
    Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People s Republic of China
    J Surg Oncol 104:538-43. 2011
    b>Ezrin, a member of the ezrin-radixin-moesin family, was implicated in tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including esophageal squamous cell carcinoma (ESCC)...
  5. ncbi Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member
    Leena Heiska
    Department of Pathology, Neuroscience Program, Biomedicum Helsinki, University of Helsinki and Helsinki University Hospital, FIN 00014 Helsinki, Finland
    J Biol Chem 280:10244-52. 2005
    b>Ezrin, a linker between plasma membrane and actin cytoskeleton possesses morphogenic properties and can promote dissemination of tumor cells...
  6. pmc LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation
    Natalya V Belkina
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:4707-12. 2009
    ERM (ezrin-radixin-moesin) proteins mediate linkage of actin cytoskeleton to plasma membrane in many cells...
  7. ncbi Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas
    Wen Hui Weng
    Department of Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    Clin Cancer Res 11:6198-204. 2005
    b>Ezrin is a cytoskeleton linker protein that is actively involved in regulating the growth and metastatic capacity of cancer cells. It has recently been reported to be involved in dissemination of pediatric soft tissue sarcoma (STS).
  8. ncbi Ezrin mutants affecting dimerization and activation
    David N Chambers
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 44:3926-32. 2005
    ERM (ezrin/radixin/moesin) proteins provide a regulated linkage between membrane-associated proteins and the actin cytoskeleton...
  9. doi Ezrin is associated with gastric cancer progression and prognosis
    Li Li
    Department of Pathology, Zhejiang Provincial People s Hospital, Hangzhou 310014, People s Republic of China
    Pathol Oncol Res 17:909-15. 2011
    To investigat the clinical significance of Ezrin in the development and progression of gastric cancer. Immunohistochemistry was employed to analyze Ezrin expression in 436 clinicopathologically characterized gastric cancer cases...
  10. doi Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinoma
    You yuan Wang
    Department of Oral and Maxillofacial Surgery, Sun Yat sen Memorial Hospital No 2 Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:96-104. 2011
    The aim of this study was to investigate the relationship between membrane cytoskeleton linker protein Ezrin and CD44v6, iNOS, Ki-67, and clinicopathologic characteristics, and the prognostic significance of Ezrin expression in salivary ..
  11. ncbi Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma
    Shen Xu-Dong
    Department of Oncology, Shanghai 6th People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Clin Invest Med 32:E180-8. 2009
    To determine the prognostic value of the expression of Ezrin, CD44 and Six1 genes in osteosarcoma tissues of Chinese patients.
  12. pmc Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma
    Yong Chen
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shanxi, P R China
    Cancer Res 71:1721-9. 2011
    ..In particular, we found that Thr567 hyperphosphorylation of the cytoskeletal protein ezrin was tightly correlated to an invasive phenotype of clinical hepatocellular carcinomas and to poor outcomes in ..
  13. pmc The ezrin metastatic phenotype is associated with the initiation of protein translation
    Joseph W Briggs
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Neoplasia 14:297-310. 2012
    We previously associated the cytoskeleton linker protein, Ezrin, with the metastatic phenotype of pediatric sarcomas, including osteosarcoma and rhabdomyosarcoma...
  14. ncbi The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
    Chand Khanna
    Pediatric Oncology Branch and Tissue Array Project Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:182-6. 2004
    ..From this genomic data, we selected ezrin for further study based on its role in physically and functionally connecting the actin cytoskeleton to the cell ..
  15. pmc Src-dependent ezrin phosphorylation in adhesion-mediated signaling
    J Srivastava
    Morphogenèse et Signalisation Cellulaires, UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Mol Biol Cell 16:1481-90. 2005
    In addition to providing a regulated linkage between the membrane and the actin cytoskeleton, ezrin participates in signal transduction pathways...
  16. ncbi Knockdown of ezrin via RNA interference suppresses Helicobacter pylori-enhanced invasion of gastric cancer cells
    Li lin Fan
    Department of Gastroenterology, Southwest Hospital, Chongqing, China
    Cancer Biol Ther 11:746-52. 2011
    ..b>Ezrin, a membrane cytoskeletal crosslinker protein, is well documented to regulate cell adhesion and cell motility...
  17. pmc Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility
    T Ng
    Richard Dimbleby Department of Cancer Research, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    EMBO J 20:2723-41. 2001
    ..This PKC-driven migratory response directly correlates with increased C-terminal threonine phosphorylation of ezrin/moesin/radixin (ERM) at the wound edge...
  18. ncbi The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain
    Casey M Finnerty
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 117:1547-52. 2004
    Members of the ezrin-radixin-moesin (ERM) protein family serve as regulated microfilament-membrane crosslinking proteins that, upon activation, bind the scaffolding protein ERM-phosphoprotein of 50 kDa (EBP50). Here we report a 3...
  19. pmc The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylation
    Francesca Di Sole
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 20:1776-86. 2009
    ..protein-1 (CHP1) in opossum kidney cells increased NHE3 transport activity, surface protein abundance, and ezrin phosphorylation. CHP1 knockdown by small interfering RNA had the opposite effects...
  20. doi Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9
    Beibei Zhou
    Department of Immunology, College of Basic Medical Science, Wuhan University, Wuhan, Hubei, China
    Leuk Res 34:769-76. 2010
    Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor ..
  21. pmc 17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin
    ShuHui Zheng
    Department of Physiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e22439. 2011
    ..However, the detailed mechanism remains largely unknown. The actin binding protein ezrin is a key component in tumor metastasis and its over-expression is positively correlated to the poor outcome of ..
  22. doi Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cells
    Qingchang Li
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China
    Tumour Biol 33:1493-504. 2012
    b>Ezrin, one of the ezrin-radixin-moesin proteins, is involved in the formation of cell membrane processes such as lamellipodia and filopodia and acts as a membrane-cytoskeleton linker...
  23. pmc Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity
    Christelle Brégnard
    Hopital Necker Enfants Malades, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    J Virol 87:3729-40. 2013
    ..We observe that glucosidase II is enriched in WT virions, whereas Ezrin, ALG-2, CD81, and EHD4 are enriched in nef-deleted virions...
  24. ncbi PACE-1, a novel protein that interacts with the C-terminal domain of ezrin
    Alexandra Sullivan
    Ludwig Institute for Cancer Research, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Exp Cell Res 284:224-38. 2003
    The ERM proteins (ezrin, radixin, moesin) together with merlin comprise a subgroup of the band 4.1 superfamily...
  25. ncbi Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells
    Marylise Hebert
    Institut National de la Santé et de la Recherche Médicale U749, Faculte de Pharmacie, Chatenay Malabry, France
    J Immunol 181:5963-73. 2008
    ..It has been shown that ezrin, a member of the ERM (ezrin-radixin-moesin) protein family can link Fas to the actin cytoskeleton...
  26. pmc cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1
    K L Gould
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92138
    EMBO J 8:4133-42. 1989
    b>Ezrin is a component of the microvilli of intestinal epithelial cells and serves as a major cytoplasmic substrate for certain protein-tyrosine kinases...
  27. ncbi A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility
    James W Legg
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, Imperial College Road, London SW7 2AZ, UK
    Nat Cell Biol 4:399-407. 2002
    ..chemotaxis assays we show that phosphorylation of Ser291 modulates the interaction between CD44 and the cytoskeletal linker protein ezrin in vivo, and that this phosphorylation is critical for CD44-dependent directional cell motility.
  28. pmc Molecular analysis of microscopic ezrin dynamics by two-photon FRAP
    Sylvie Coscoy
    Laboratoires de Physico Chimie, Unité Mixte de Recherche 168 and Morphogenèse et Signalisation Cellulaires, Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 99:12813-8. 2002
    b>Ezrin plays a key role in coupling signal transduction to cortical cell organization...
  29. ncbi Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions
    William James Smith
    Department of Chemistry, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 278:4949-56. 2003
    b>Ezrin is a member of the ERM (ezrin, radixin, moesin) family of proteins that cross-link the actin cytoskeleton to the plasma membrane and also may function in signaling cascades that regulate the assembly of actin stress fibers...
  30. pmc Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cells
    Michelle L Janket
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Virus Res 126:76-85. 2007
    ..NHE1 downregulation further led to acidification of cells and was directly correlated with loss of ezrin, radixin and moesin (ERM) protein complex and decreased AKT phosphorylation...
  31. pmc Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42
    Soren Prag
    Richard Dimbleby Department of Cancer Research, King s College London, Guy s Medical School Campus, London SE1 1UL, United Kingdom
    Mol Biol Cell 18:2935-48. 2007
    ..Here, we describe a novel role of the actin-binding ezrin/radixin/moesin (ERM)-protein ezrin to be involved in recruiting Cdc42, but not Rac1, to lipid raft microdomains, ..
  32. doi Properties of an ezrin mutant defective in F-actin binding
    Henri S Saleh
    Leibniz Institute of Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    J Mol Biol 385:1015-31. 2009
    b>Ezrin, radixin and moesin are a family of proteins that provide a link between the plasma membrane and the cortical actin cytoskeleton...
  33. pmc Moesin: a member of the protein 4.1-talin-ezrin family of proteins
    W T Lankes
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Proc Natl Acad Sci U S A 88:8297-301. 1991
    ..In addition, the protein shows significant sequence identity (72%) to ezrin (cytovillin, p81), as well as similarity to protein 4.1 and talin...
  34. pmc Cytoskeletal proteins inside human immunodeficiency virus type 1 virions
    D E Ott
    AIDS Vaccine Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Virol 70:7734-43. 1996
    ..in virions at different concentrations relative to the molar level of Gag: actin (approximately 10 to 15%), ezrin and moesin (approximately 2%), and cofilin (approximately 2 to 10%)...
  35. ncbi Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
    K Takahashi
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan
    J Biol Chem 272:23371-5. 1997
    ..We have reported that the Rho subfamily members regulate the ezrin/radixin/moesin (ERM)-CD44 system, implicated in reorganization of actin filaments...
  36. ncbi NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin
    C H Yun
    Department of Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:25856-63. 1998
    ..As shown earlier for the human homolog of NHERF, we also found that the cytoskeletal protein ezrin binds to the carboxyl-terminal domain of E3KARP...
  37. ncbi The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly
    P Matarrese
    Department of Ultrastructures, Instituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Cell Death Differ 7:25-36. 2000
    ..e. by inducing anoikis-resistance. These particular effects of vpr might enhance the homing, spreading and survival of the infected lymphocytes, thus contributing to virus persistence in the course of acute HIV-1 infection...
  38. ncbi Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells
    J L Alonso-Lebrero
    Servicio de Inmunologia, Hospital de la Princesa, Madrid, Spain Northwestern University Medical School, Chicago, IL, USA
    Blood 95:2413-9. 2000
    ..Bands of 78- and 81-kd were identified as moesin and ezrin by Western blot analysis...
  39. pmc CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway
    S Parlato
    Laboratories of Virology, Istituto Superiore di Sanità Viale Regina Elena 299, 00161 Rome, Italy
    EMBO J 19:5123-34. 2000
    ..to CD95-mediated apoptosis, exhibit a constitutive polarized morphology, and that CD95 colocalizes with ezrin at the site of cellular polarization...
  40. pmc Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
    Olga Barreiro
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Cell Biol 157:1233-45. 2002
    b>Ezrin, radixin, and moesin (ERM) regulate cortical morphogenesis and cell adhesion by connecting membrane adhesion receptors to the actin-based cytoskeleton...
  41. ncbi ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1
    Ana Urzainqui
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Immunity 17:401-12. 2002
    ..This association is mediated by the actin-linking proteins moesin and ezrin, which directly interact with Syk in an ITAM-dependent manner...
  42. ncbi The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival
    Karen L Wu
    Department of Medicine, Rammelkamp Center for Research, MetroHealth Medical Center Campus, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Biol Chem 279:26280-6. 2004
    ..In addition to mediating Na(+)/H(+) transport, NHE1 interacts with ezrin/radixin/moesin (ERM), which tethers NHE1 to cortical actin cytoskeleton to regulate cell shape, adhesion, motility,..
  43. ncbi Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering
    Aleksandar Ivetic
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS United Kingdom
    J Biol Chem 279:33263-72. 2004
    ..We have previously identified ezrin and moesin as novel binding partners of the 17-amino acid L-selectin tail, but the biological role of this ..
  44. ncbi Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death
    P Matarrese
    Section of Cell Aging and Degeneration, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Cell Death Differ 12:932-41. 2005
    ..The microfilament system seems thus to be a sort of cytoplasmic supervisor of the viral particle, the host cell and the bystander cell's very fate...
  45. ncbi Ezrin expression in prostate cancer and benign prostatic tissue
    Alexander Valdman
    Department of Surgical Science, Section of Urology, Karolinska Institute, Stockholm, Sweden
    Eur Urol 48:852-7. 2005
    The membrane-linking protein ezrin is highly expressed in several types of human cancers and correlations between its immunoreactivity and histopathological data as well as patient outcome have previously been shown...
  46. ncbi Androgen induction of prostate cancer cell invasion is mediated by ezrin
    Yin Choy Chuan
    Department of Molecular Medicine and Surgery, Section of Experimental Geriatrics, Karolinska Institute, Neurotec, Stockholm, Sweden
    J Biol Chem 281:29938-48. 2006
    b>Ezrin is a key signaling molecule that regulates cell survival, adhesion migration, and invasion...
  47. ncbi The CD44 standard/ezrin complex regulates Fas-mediated apoptosis in Jurkat cells
    Ainhoa Mielgo
    Institute of Medical Microbiology, Department of Clinical and Biological Sciences, University of Basel, Petersplatz 10, 4003 Basel, Switzerland
    Apoptosis 12:2051-61. 2007
    ..CD44 is a binding partner for the membrane-cytoskeleton cross-linker protein ezrin. In this study, we demonstrate that only CD44 standard (CD44s) colocalizes and interacts with the actin cross-..
  48. pmc Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma
    Chun Nan Yeh
    Department of Surgery, Chang Gung Memorial Hospital Chang Gung University, Taoyuan, Taiwan, ROC
    BMC Cancer 9:233. 2009
    ..Only 5% of the general population is seronegative for all hepatititis B virus (HBV) markers. This is the first study to determine the role of ezrin upon HBV HCC cell and patients with HBV HCC undergoing hepatectomy
  49. doi Ezrin overexpression in gastrointestinal stromal tumors: an independent adverse prognosticator associated with the non-gastric location
    Yu Ching Wei
    Department of Pathology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Mod Pathol 22:1351-60. 2009
    b>Ezrin, a member of the ezrin-radixin-moesin family, acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-mediated signaling...
  50. ncbi Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate
    L Heiska
    Department of Pathology, University of Helsinki, Haartman Institute, 00014 Helsinki, Finland
    J Biol Chem 273:21893-900. 1998
    b>Ezrin is a cytoplasmic linker molecule between plasma membrane components and the actin-containing cytoskeleton. We studied whether ezrin is associated with intercellular adhesion molecule (ICAM)-1, -2, and -3...
  51. ncbi Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain
    A Shcherbina
    The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    FEBS Lett 443:31-6. 1999
    The ERM proteins, ezrin, radixin and moesin, provide regulated linkage of the cytoskeleton with the plasma membrane, particularly in cell surface projections...
  52. pmc Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli
    M Berryman
    Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
    Mol Biol Cell 11:1509-21. 2000
    ..as a component of a multimeric complex consisting of several known cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1...
  53. pmc Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
    C Tran Quang
    Transcription Laboratory, Room 528, Imperial Cancer Research Fund Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 19:4565-76. 2000
    ..We investigated the role of the cytoskeletal linker protein ezrin in this process...
  54. pmc Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
    D Reczek
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 153:191-206. 2001
    ..EPI64 colocalizes with EBP50 and ezrin in syncytiotrophoblast and cultured cell microvilli, and this localization in cultured cells is abolished by ..
  55. ncbi The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin
    Aleksandar Ivetic
    Divisions of Cellular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    J Biol Chem 277:2321-9. 2002
    ..By using this approach, members of the Ezrin-Radixin-Moesin family of proteins were found to interact specifically with the cytoplasmic tail of L-selectin...
  56. ncbi A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting
    Juan M Serrador
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid 28006, Spain
    J Biol Chem 277:10400-9. 2002
    ..We have investigated the interaction between ICAM-3 and ezrin/radixin/moesin (ERM) proteins and its role in LFA-1-induced cell-cell interactions and membrane positioning of ..
  57. ncbi Identification of a novel Ezrin-binding site in syndecan-2 cytoplasmic domain
    Francesc Granes
    Department of Cellular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
    FEBS Lett 547:212-6. 2003
    ERM (Ezrin/Radixin/Moesin) proteins are crosslinkers between plasma membrane proteins and the actin cytoskeleton, thereby involved in the formation of cell adhesion sites...
  58. ncbi A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells
    Beate K Straub
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 116:4985-95. 2003
    ..The other complex contains ezrin, periplakin, periaxin and desmoyokin (and so is called the EPPD complex), usually together with moesin, spectrin(s)..
  59. pmc G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton
    Sarah H Cant
    MRC Laboratory for Molecular and Cellular Biology and Department of Pharmacology, University College London, London, WC1E 6BT United Kingdom
    Mol Biol Cell 16:3088-99. 2005
    ..Here, we identify ezrin as a novel non-GPCR substrate of GRK2...
  60. ncbi Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling
    Laura Stanasila
    Département de Pharmacologie et de Toxicologie, Faculté de Biologie et de Médecine, Lausanne, Switzerland
    J Biol Chem 281:4354-63. 2006
    Using the yeast two-hybrid system, we identified ezrin as a protein interacting with the C-tail of the alpha1b-adrenergic receptor (AR)...
  61. ncbi Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas
    David Sarrio
    Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Breast Cancer Res Treat 98:71-9. 2006
    The membrane-cytoskeleton crosslinker ezrin is associated with malignant progression and metastasis in human neoplasias...
  62. ncbi Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas
    Martin Köbel
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Mod Pathol 19:581-7. 2006
    As a cortical cytoskeletal protein, ezrin adapts the cytoplasmic tail of CD44 to the actin-based cytoskeleton and is functionally involved in migration and adhesion that are prerequisites for metastasis...
  63. ncbi Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases
    Xiyun Deng
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Clin Exp Metastasis 24:107-19. 2007
    ..Five of the nine up-regulated genes, including caveolin 1, CD44, EphB2, ezrin, and Parathyroid hormone-related protein (PTHrP), and one down-regulated gene, SLPI, were further confirmed by ..
  64. ncbi Expression of the cytoskeleton linker protein ezrin in human cancers
    Benjamin Bruce
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Clin Exp Metastasis 24:69-78. 2007
    Expression of the metastasis-associated protein, ezrin, in over 5,000 human cancers and normal tissues was analyzed using tissue microarray immunohistochemistry...
  65. pmc Association of ezrin expression in intestinal and diffuse gastric carcinoma with clinicopathological parameters and tumor type
    Nebil Bal
    Baskent University, Adana Research and Medical Center, Pathology Department, Yuregir, Adana 01250, Turkey
    World J Gastroenterol 13:3726-9. 2007
    To investigate the correlation between ezrin expression and types of gastric carcinoma and clinico-pathological variables.
  66. doi Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection
    Yoshinao Kubo
    Department of AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, National Institute of Infectious Diseases, Tokyo, Japan
    Virology 375:130-40. 2008
    b>Ezrin, radixin, and moesin (ERM) proteins supply functional linkage between integral membrane proteins and cytoskeleton in mammalian cells to regulate membrane protein dynamisms and cytoskeleton rearrangement...
  67. doi Ezrin is a key element in the human vagina
    A Fadiel
    Department of Obstetrics and Gynecology, New York University, 550 First Avenue, TH528, New York, NY 10016, United States
    Maturitas 60:31-41. 2008
    ..This integration is the domain of cytoskeletal proteins including the MERM protein family (moesin-ezrin-radixin-Merlin)...
  68. doi The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
    L Ren
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 28:792-802. 2009
    b>Ezrin is a member of the ERM (ezrin, radixin, moesin) protein family and links F-actin to the cell membrane following phosphorylation...
  69. doi Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells
    Jian Jun Xie
    Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People s Republic of China
    Int J Cancer 124:2549-58. 2009
    b>Ezrin, which crosslinks the cytoskeleton and plasma membrane, is involved in the growth and metastatic potential of cancer cells...
  70. pmc Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration
    K Endo
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Oncogene 28:1725-35. 2009
    ..Recently, the membrane crosslinker protein, ezrin, has been implicated in tumor cell metastasis and malignant progression...
  71. ncbi Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw
    Hye Rim Park
    Department of Pathology College of Medicine, Hallym University, Anyang, Korea
    Tumori 95:81-6. 2009
    b>Ezrin is a membrane-cytoskeleton linker protein involved in regulation of the growth and metastatic behavior of cancer cells. Metastatic tumor antigen (MTA) is a potential metastasis-associated protein...
  72. pmc Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1
    Jianquan Li
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Mol Biol 392:166-80. 2009
    ..This CT domain binds to ezrin, which, in turn, interacts with cytosekeletal actin...
  73. pmc Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse
    Rémi Lasserre
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
    EMBO J 29:2301-14. 2010
    ..We show here that the membrane-microfilament linker ezrin has an important function in microcluster dynamics and in TCR signalling through its ability to set the ..
  74. doi Prognostic implication of ezrin overexpression in myxofibrosarcomas
    Hsuan Ying Huang
    Department of Pathology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung County 833, Taiwan
    Ann Surg Oncol 17:3212-9. 2010
    The bases of tumorigenesis, progression, and metastasis remain obscure in myxofibrosarcoma. As a member of ezrin-radixin-moesin family, ezrin acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-..
  75. doi Expression change of ezrin as a prognostic factor in primary osteosarcoma
    Yao Fei Wang
    Department of Orthopaedic Surgery, Musculoskeletal Tumor Center, the First Affiliated Hospital of Sun Yat Sen University, No 58 Zhongshan 2nd road, 510080 Guangzhou, Guangdong, China
    Med Oncol 28:S636-43. 2011
    Osteosarcoma is a life-threatening malignancy that most often occurs in teenagers. Ezrin is a cytoskeleton linker protein that is actively involved in the metastatic capacity of cancer cells...
  76. pmc Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress
    Miguel Fidalgo
    Department of Physiology and Centro Singular de Medicina Molecular y Enfermedades Crónicas CIMUS, University of Santiago de Compostela, Spain
    J Biol Chem 287:11556-65. 2012
    ..that it is involved in a novel response to oxidative stress that results in phosphorylation and activation of the ezrin/radixin/moesin (ERM) family of proteins...
  77. pmc Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts
    Gustav Andersson
    Department of Clinical Sciences, Oncology and Pathology, Lund University, Skane University Hospital, Lund 221 85, Sweden
    BMC Urol 14:36. 2014
    Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcinoma of the bladder treated ..
  78. ncbi Ezrin has properties to self-associate at the plasma membrane
    C Andreoli
    CNRS URA 1856, Universite Montpellier II, Département Biologie Santé, France
    J Cell Sci 107:2509-21. 1994
    b>Ezrin, a member of a family of proteins involved in the interaction of the microfilament cytoskeleton with the plasma membrane, plays a role in membrane translocation in gastric parietal cells (Hanzel, D., Reggio, H., Bretscher, A...
  79. pmc Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family
    O Turunen
    Haartman Institute, Department of Virology, Helsinki University, Finland
    J Cell Biol 126:1445-53. 1994
    b>Ezrin, previously also known as cytovillin, p81, and 80K, is a cytoplasmic protein enriched in microvilli and other cell surface structures. Ezrin is postulated to have a membrane-cytoskeleton linker role...
  80. pmc Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
    Proc Natl Acad Sci U S A 90:10846-50. 1993
    b>Ezrin and moesin are components of actin-rich cell surface structures that are thought to function as membrane-cytoskeletal linking proteins...
  81. pmc Ezrin is a cyclic AMP-dependent protein kinase anchoring protein
    D T Dransfield
    Institute of Molecular Medicine and Genetics, Medical College of Georgia and the Augusta Veterans Affairs Medical Center, 30912, USA
    EMBO J 16:35-43. 1997
    ..The purified 78 kDa AKAP was recognized by monoclonal antibodies against ezrin, the canalicular actin-associated protein...
  82. pmc Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
    D Reczek
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 139:169-79. 1997
    Members of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linking proteins have NH2- and COOH-terminal domains that associate with the plasma membrane and the actin cytoskeleton, respectively...
  83. ncbi CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts
    J M Serrador
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Blood 91:4632-44. 1998
    ..Immunofluorescence analysis showed that all three ezrin-radixin-moesin (ERM) actin-binding proteins localized in the uropod of both human T lymphoblasts stimulated with ..
  84. pmc Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
    A Gautreau
    Laboratoire de Morphogenèse et Signalisation Cellulaires, Unite Mixte de Recherche, 144 Centre National de la Recherche Scientifique Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 96:7300-5. 1999
    ERM (Ezrin-Radixin-Moesin) proteins function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains of the plasma membrane...
  85. ncbi Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin
    S Hiscox
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    J Cell Sci 112:3081-90. 1999
    b>Ezrin, radixin, moesin and merlin form a subfamily of conserved proteins in the band 4.1 superfamily. The function of these proteins is to link the plasma membrane to the actin cytoskeleton...
  86. ncbi The role of the CD44/ezrin complex in cancer metastasis
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, S Wales CF14 4XN, UK
    Crit Rev Oncol Hematol 46:165-86. 2003
    ..This molecule is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, ..
  87. ncbi Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma
    Hye Rim Park
    Department of Pathology, College of Medicine, Hallym University, Anyang, Republic of Korea
    Pathol Res Pract 202:509-15. 2006
    b>Ezrin is a cytoskeleton linker protein that is actively involved in the regulation of growth and metastatic capacity of cancer cells...
  88. ncbi Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma
    Stefano Ferrari
    Chemotherapy Unit, Istituto Ortopedico Rizzoli, Bologna, Italy
    Pediatr Blood Cancer 50:752-6. 2008
    b>Ezrin is a membrane-cytoskeleton linker protein involved in regulating growth and metastatic behaviour of cancer cells. The study evaluated ezrin expression and its prognostic value in patients with non-metastatic osteosarcoma.
  89. ncbi Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells
    Qiong Li
    Cancer Biology Research Center, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Anv, Wuhan, Hubei 430030, PR China
    Cancer Lett 261:55-63. 2008
    b>Ezrin primarily acts as a linker between the plasma membrane and the cytoskeleton and is a key component in tumor metastasis...
  90. pmc The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infection
    Juliane Haedicke
    Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland
    J Virol 82:4665-70. 2008
    ..Here, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia ..
  91. doi Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer
    Adam Elzagheid
    Department of Oncology and Radiotherapy, Turku University Hospital, FIN 20521 Turku, Finland
    Hum Pathol 39:1737-43. 2008
    b>Ezrin is a membrane-cytoskeleton anchor, which, in experimental models, regulates tumor cell invasion and metastatic ability...
  92. doi Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cells
    H M Kocher
    Centre for Tumour Biology, Institute of Cancer and CR UK Clinical Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London, UK
    Gut 58:271-84. 2009
    Pancreatic cancer is a highly invasive malignancy. Ezrin, a plasma membrane-cytoskeletal linker protein, is associated with the invasive behaviour of cancers...
  93. pmc Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells
    Shu Ying Gao
    Department of Biochemistry and Molecular Biology, Shantou University, Shantou, China
    J Biol Chem 284:7995-8004. 2009
    b>Ezrin, encoded by VIL2, is a membrane-cytoskeletal linker protein that has been suggested to be involved in tumorigenesis...
  94. doi Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex
    Jean Paul ten Klooster
    Hubrecht Institute, KNAW and University Medical Centre, Utrecht, The Netherlands
    Dev Cell 16:551-62. 2009
    ..As an essential event in brush border formation, Mst4 phosphorylates the regulatory T567 residue of Ezrin. These data define a brush border induction pathway downstream of the Lkb1/Strad/Mo25 polarization complex, yet ..
  95. doi Ezrin is a negative regulator of death receptor-induced apoptosis
    W C Kuo
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    Oncogene 29:1374-83. 2010
    b>Ezrin links cortical actin filaments with the cell membrane, and has a critical role in many membrane-initiated events...
  96. doi Ezrin mediates c-Myc actions in prostate cancer cell invasion
    Y C Chuan
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Oncogene 29:1531-42. 2010
    ..We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens...
  97. doi Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma
    Zhi qiang Ling
    Department of Pathology, Shiga University of Medical Science, Shiga, Japan
    Cancer Sci 101:624-30. 2010
    ..Of the many genes identified, we detected an interesting ezrin amplicon that has been recently reported in human ESCC...
  98. pmc A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization
    David P LaLonde
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 21:1519-29. 2010
    PDZK1 and ezrin, radixin, moesin binding phosphoprotein 50 kDa (EBP50) are postsynaptic density 95/disc-large/zona occludens (PDZ)-domain-containing scaffolding proteins found in the apical microvilli of polarized epithelial cells...
  99. pmc Ezrin promotes invasion and metastasis of pancreatic cancer cells
    Yunxiao Meng
    Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, 1 Shuai Fu Yuan Hu Tong, Beijing, China
    J Transl Med 8:61. 2010
    ..b>Ezrin plays important roles in cell motility, invasion and tumor progression, and it is especially crucial for ..
  100. ncbi Role for ezrin in breast cancer cell chemotaxis to CCL5
    Juanjuan Li
    Department of Breast and Thyroid Gland Surgery of Renmin Hospital of Wuhan University, the First College of Clinical Medicine of Wuhan University, Wuhan, Hubei 430060, P R China
    Oncol Rep 24:965-71. 2010
    This study was undertaken to observe the effects and the possible mechanism of membrane-cytoskeleton linker ezrin on the chemokine CC chemokine ligand 5 (CCL5)-induced invasive ability in human breast carcinoma MCF-7 cells...
  101. doi Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with rectal cancer
    Eija A Korkeila
    Department of Oncology and Radiotherapy, University of Turku, Turku University Hospital, Hämeentie 11, PB 52, FIN 20521 Turku, Finland
    Hum Pathol 42:384-92. 2011
    The purpose of this study was to assess the value of ezrin expression as a predictor of disease outcome in rectal cancer treated by preoperative radio- or chemoradiotherapy...

Research Grants41

  1. Effect of Lactobacillus on genital HIV-1 RNA and DNA shedding in women
    Jane E Hitti; Fiscal Year: 2010
    ..We propose to evaluate this hypothesis using archived cervicovaginal lavage (CVL) and cervical cytobrush samples from parallel cohorts of HIV-1-infected women in the United States and Kenya...
  2. Anna Wald; Fiscal Year: 2016
    ..factors MIP-1[unreadable], IL-1[unreadable], and IL-8, measured by Luminex assays in cervicovaginal lavage (CVL) samples from adolescent women before and after initiation of sexual activity, and after HSV-2 seroconversion...
  3. Genetic Risk Factors for Visceral Leishmaniasis
    Mary E Wilson; Fiscal Year: 2013
    ..provided by applicant): Three major worldwide foci of the fatal parasitic disease visceral leishmaniasis (cVL) occur in India, Sudan and Brazil...
  4. Leslie A Parker; Fiscal Year: 2016
    ..parenteral nutrition associated liver disease (PNALD), poor growth, more hours requiring a central venous line (CVL), increased risk of late onset sepsis (LOS), prolonged hospitalization, as well as disturbances in gastrointestinal ..
  5. HIV Integrase as a Target for Topical MIcrobicide Development
    Mary Klotman; Fiscal Year: 2009
    ..rhesus macaque (RM) cervicovaginal explants along with a similar analysis of tissue and cervical vaginal lavage (CVL) fluid derived from in vivo RM studies in the R33 phase will validate the cervicovaginal explant model as a screen ..
  6. KIMBERLY POWERS; Fiscal Year: 2014
    ..Currently, the US National HIV/AIDS Strategy recommends "community viral load" (CVL) as a metric for this purpose, and the US Centers for Disease Control and Prevention have issued guidance on the ..
  7. JOHN CHRISTIAN TILTON; Fiscal Year: 2016
    ..2. Quantify bacterial species and metabolites present in cervicovaginal lavage (CVL) samples and correlate metabolites with specific species or groups of bacteria...
  8. Mark H Einstein; Fiscal Year: 2015
    ..Female genital tract secretions will be collected by cervicovaginal lavage (CVL) at different times post-application and spiked with HPV pseudovirions in the absence and presence of seminal ..
  9. Novel Evaluation Methods for Multi-Level/Combination HIV Prevention Interventions
    EDWIN DUNCAN CHARLEBOIS; Fiscal Year: 2013
    ..However, such comprehensive methods do not exist. The recent development of the concept of Community Viral Load (CVL), presents a significant opportunity to evaluate T2 translational research (bedside-to-community) at the community ..
  10. The Role of Mucosal Immunity in the Risk of HIV-1 Acquisition During Pregnancy
    Brenna L Anderson; Fiscal Year: 2013
    ..The hypothesis to be tested is that the cervicovaginal lavage (CVL) of pregnant women will inhibit HIV infectivity to a lesser extent than that of non-pregnant women...
  11. RENOVATION OF NINTH FLOOR OF BURNETT-WOMACK
    WILLIAM ROPER; Fiscal Year: 2004
    ..and bio-defense; three members of the Infectious Disease Center who have collaborative relationships with the CVl in order to provide the space they need to support their growing research preclinical programs in pathogens which ..
  12. MUCOSALLY DELIVERED DNA/MVA VACCINES IN A SHIV MODEL
    Thomas VanCott; Fiscal Year: 2004
    ..Furthermore, the macaque CVL IgA responses were capable of neutralizing SHIV-89.6PD infection of cultures of dendritic cells and T cells in vivo...
  13. Recombinant CCR5 Inhibitors for Topical Microbicides
    Donald Mosier; Fiscal Year: 2007
    ..and compare the stability of the molecules to low pH, high temperature, and exposure to cervicovaginal lavage (CVL) fluid...
  14. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  15. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  17. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  18. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  19. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  20. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  21. ANTI-HIV-1 ACTIVITY OF MANNAN-BINDING LECTIN
    Gregory Spear; Fiscal Year: 2003
    ..3. Utilize inhibitors of glycosylation to enhance biological effects of MBL. Exarnine the interaction of MBL with anti-viral antibodies in mediating anti-viral effects. Deterrnine the interaction of HIV-1 with MBL in vivo. ..
  22. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  23. Randomized trial of HIV / STD prevention in Zimbabwean youth
    Frances Cowan; Fiscal Year: 2006
    ..The most valid method will then be used in the final outcomes survey for the parent trial. [unreadable] [unreadable] [unreadable]..
  24. Trial of Vitamins in HIV Progression and Transmission
    Wafaie Fawzi; Fiscal Year: 2009
    ..The study is a collaborative effort between Harvard School of Public Health and Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania. ..
  25. Trial of Vitamins among Children of HIV-infected Mothers
    Wafaie Fawzi; Fiscal Year: 2007
    ..The study will be carried out as a collaborative effort between the Harvard School of Public Health and Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania. ..
  26. ANTIVIRAL THERAPY AND HIV IN THE GENITAL TRACT OF WOMEN
    Susan Cu Uvin; Fiscal Year: 2007
    ..We also propose to enroll women who have undergone total hysterectomy to assess HIV dynamics in the vagina. ..
  27. Partnership on Nutrition and HIV/AIDS Research in Tanza*
    Wafaie Fawzi; Fiscal Year: 2006
    ..The program will be carried out as a collaborative effort between Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania and the Harvard School of Public Health, Boston, MA. ..
  28. HPV Induced Pathogenesis in Head and Neck Cancer
    NICOLAS SCHLECHT; Fiscal Year: 2006
    ..abstract_text> ..
  29. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2005
    ..abstract_text> ..
  30. NUTRITION, IMMUNOLOGY, AND EPIDEMIOLOGY OF TB
    Wafaie Fawzi; Fiscal Year: 2004
    ..abstract_text> ..
  31. Epidemiology of HIV-1/HIV-2 Dual Infection
    Geoffrey Gottlieb; Fiscal Year: 2005
    ....
  32. Characterization of intestinal adenosine A2b receptor
    Shanthi Sitaraman; Fiscal Year: 2004
    ..Specific aim 3: We will study: i) the effect of IL-6 on degranulation of neutrophils. ..
  33. INTESTINAL ADENOSINE A2B RECEPTOR
    Shanthi Sitaraman; Fiscal Year: 2004
    ..Third, I will study the role of adenosine receptor in the modulation and feedback regulation of neutrophil-epithelial interaction including transmigration and chemokine secretion. ..
  34. HIV PREVENTION TRIALS UNIT
    Wafaie Fawzi; Fiscal Year: 2004
    ..S., the commitment of the authorities in Tanzania to HIV research, and the political stability in Tanzania, would make this collaboration a valuable addition to the HPTN. ..
  35. HIV-1 Specific Cytotoxic T Lymphocytes in Breastmilk
    Grace John Stewart; Fiscal Year: 2003
    ..The resulting findings will be relevant to development of vaccines for prevention of mother-to-child transmission of HIV-1. ..
  36. A TRAIL OF MICRONUTRIENTS AND ADVERSE PREGNACY OUTCOMES
    Wafaie Fawzi; Fiscal Year: 2003
    ..To examine potential mechanisms of action of the supplements or dietary patterns and intake of individual nutrients, they will assess the following secondary outcomes among women: hemoglobin levels, T cell counts, and placental weight. ..
  37. PEDIATRIC ONCOLOGY GROUP STUDIES
    Thomas McLean; Fiscal Year: 2002
    ....
  38. Role of Clic in Epithelial Morphogenesis
    Mark Berryman; Fiscal Year: 2008
    ..The fruit fly will be used as a model system to understand how Clic works with other genes and proteins known to be important for cell shape and movement during embryonic development. [unreadable] [unreadable] [unreadable]..
  39. The Role of Connexin32 in the Pathogenesis of CMTX
    Steven Scherer; Fiscal Year: 2006
    ....
  40. Axonal alterations in demyelinating diseases
    STEVEN SIMON SCHERER; Fiscal Year: 2011
    ..Aim #3: What Na,K-ATPase isoforms are expressed by myelinated axons and demyelinated axons? we will localize alpha1-3 by immunoelectron microscopy in CMSand PNS myelinated axons, along with their beta subunits. ..