ERM

Summary

Gene Symbol: ERM
Description: ETS variant 5
Alias: ERM, ETS translocation variant 5, ets-related molecule, ets-related protein ERM
Species: human

Top Publications

  1. ncbi [Differentiation of resistance phenotypes among erythromycin-resistant streptococci]
    Danijela Bejuk
    Zavod za klinicku mikrobiologiju i hospitalne infekcije, Opca bolnica Sveti Duh, Zagreb, Hrvatska
    Acta Med Croatica 58:301-6. 2004
  2. ncbi Susceptibilities of Streptococcus pyogenes and Streptococcus pneumoniae to macrolides and telithromycin: data from an Italian multicenter study
    A Mazzariol
    Departimento di Patologia, Sezione di Microbiologia, Univerdità degli Studi di Verona, Strada Le Grazie 8, 37134 Verona, Italy
    J Chemother 19:500-7. 2007
  3. doi Molecular characterization of macrolide resistance determinants [erm(B) and mef(A)] in Streptococcus pneumoniae and viridans group streptococci (VGS) isolated from adult patients with cystic fibrosis (CF)
    Akihiro Tazumi
    Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, Northern Ireland, UK
    J Antimicrob Chemother 64:501-6. 2009
  4. ncbi [Investigation of macrolide-lincosamide-streptogramin B (MLS(B)) and telithromycin resistance in clinical strains of staphylococci]
    Zeynep Saribas
    Hacettepe Universitesi Tip Fakultesi, Tibbi Mikrobiyoloji Anabilim Dali, Ankara
    Mikrobiyol Bul 44:177-86. 2010
  5. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
  6. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
  7. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
  8. pmc Development and application of real-time PCR assays for quantification of erm genes conferring resistance to macrolides-lincosamides-streptogramin B in livestock manure and manure management systems
    Jing Chen
    The MAPLE Research Initiative, Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA
    Appl Environ Microbiol 73:4407-16. 2007
  9. doi Technical note: Occurrence in fecal microbiota of genes conferring resistance to both macrolide-lincosamide-streptogramin B and tetracyclines concomitant with feeding of beef cattle with tylosin
    J Chen
    Department of Animal Sciences, The Ohio State University, Columbus 43210, USA
    J Anim Sci 86:2385-91. 2008
  10. pmc Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene
    Kseniya Golovnina
    Institute of Cytology and Genetics, Russian Academy of Sciences, 630090, Novosibirsk, Russia
    BMC Evol Biol 5:69. 2005

Research Grants

  1. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
  2. Mechanisms of macrolide resistance in mycobacteria
    Kevin A Nash; Fiscal Year: 2010
  3. Mechanism of Induction of erm Genes By Ketolide Antibiotics
    Nora Vazquez Laslop; Fiscal Year: 2010
  4. Role of the Listeria protein InlC and its host ligand Tuba in cell-cell spread
    KEITH PATRICK IRETON; Fiscal Year: 2009
  5. Filippo G Giancotti; Fiscal Year: 2014
  6. Molecular Mechanism of cell-cell spread of Listeria in polarized epithelial cells
    KEITH PATRICK IRETON; Fiscal Year: 2013
  7. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
  8. FRANKLIN D COSTANTINI; Fiscal Year: 2014
  9. Regulation of glioblastoma migration by PTEN PDZ-binding domain
    Andrew M Chan; Fiscal Year: 2010
  10. MECHANISMS OF NERVE GROWTH CONE TURNING AND BRANCHING
    Paul C Letourneau; Fiscal Year: 2013

Detail Information

Publications313 found, 100 shown here

  1. ncbi [Differentiation of resistance phenotypes among erythromycin-resistant streptococci]
    Danijela Bejuk
    Zavod za klinicku mikrobiologiju i hospitalne infekcije, Opca bolnica Sveti Duh, Zagreb, Hrvatska
    Acta Med Croatica 58:301-6. 2004
    ..MLS resistance is mediated by two classes of methylase genes--the conventional erm(B) and recently described erm(A) determinants...
  2. ncbi Susceptibilities of Streptococcus pyogenes and Streptococcus pneumoniae to macrolides and telithromycin: data from an Italian multicenter study
    A Mazzariol
    Departimento di Patologia, Sezione di Microbiologia, Univerdità degli Studi di Verona, Strada Le Grazie 8, 37134 Verona, Italy
    J Chemother 19:500-7. 2007
    ..3% iMLS B resistance, and 27.4% Mtype resistance. All cMLS B strains had the erm(B) gene, all M strains had the mef (A) gene, and no resistance genes were found in the erythromycin-susceptible ..
  3. doi Molecular characterization of macrolide resistance determinants [erm(B) and mef(A)] in Streptococcus pneumoniae and viridans group streptococci (VGS) isolated from adult patients with cystic fibrosis (CF)
    Akihiro Tazumi
    Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, Northern Ireland, UK
    J Antimicrob Chemother 64:501-6. 2009
    ..We therefore suggest that long-term use of azithromycin increases macrolide resistance in commensal streptococci...
  4. ncbi [Investigation of macrolide-lincosamide-streptogramin B (MLS(B)) and telithromycin resistance in clinical strains of staphylococci]
    Zeynep Saribas
    Hacettepe Universitesi Tip Fakultesi, Tibbi Mikrobiyoloji Anabilim Dali, Ankara
    Mikrobiyol Bul 44:177-86. 2010
    ..Distribution of erm genes was detected by PCR method. Of 381 isolates 112 (29.4%) S. aureus and 58 (61...
  5. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity...
  6. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
    ..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
  7. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  8. pmc Development and application of real-time PCR assays for quantification of erm genes conferring resistance to macrolides-lincosamides-streptogramin B in livestock manure and manure management systems
    Jing Chen
    The MAPLE Research Initiative, Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA
    Appl Environ Microbiol 73:4407-16. 2007
    ..We report here the development, validation, and use of six real-time PCR assays for quantifying six classes of erm genes (classes A through C, F, T, and X) that encode the major mechanism of resistance to macrolides-lincosamides-..
  9. doi Technical note: Occurrence in fecal microbiota of genes conferring resistance to both macrolide-lincosamide-streptogramin B and tetracyclines concomitant with feeding of beef cattle with tylosin
    J Chen
    Department of Animal Sciences, The Ohio State University, Columbus 43210, USA
    J Anim Sci 86:2385-91. 2008
    ..9 mg/ kg of feed, respectively, DM) in feed. The abundance of genes conferring resistance to MLS(B) (erm genes) and tetracyclines (tet genes) were quantified using class-specific, real-time PCR assays...
  10. pmc Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene
    Kseniya Golovnina
    Institute of Cytology and Genetics, Russian Academy of Sciences, 630090, Novosibirsk, Russia
    BMC Evol Biol 5:69. 2005
    ..Merlin, the product of the Neurofibromatosis type 2 (NF2) tumor suppressor gene, belongs to the ezrin-radixin-moesin (ERM) subgroup of the protein 4.1 superfamily, which links cell surface glycoproteins to the actin cytoskeleton...
  11. doi A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida
    Benoit Desmolaize
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Mol Microbiol 80:184-94. 2011
    ..of the 23S rRNAs by mass spectrometry revealed that nucleotide A2058 is monomethylated, consistent with a Type I erm phenotype conferring macrolide-lincosamide resistance...
  12. pmc Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B)
    Elia Gómez G de la Pedrosa
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, and CIBER ESP, Madrid, Spain
    Antimicrob Agents Chemother 52:1964-9. 2008
    ..sequencing types) of 45 mef-positive Streptococcus pneumoniae isolates [carrying mef alone (n = 17) or with the erm(B) gene n = 28)] were studied...
  13. doi Spectral-domain optical coherence tomography for monitoring epiretinal membrane surgery
    Christiane I Falkner-Radler
    The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Lasersurgery, Department of Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria
    Ophthalmology 117:798-805. 2010
    To assess prognostic factors in epiretinal membrane (ERM) surgery using spectral-domain (SD) optical coherence tomography (OCT).
  14. ncbi Complete epiretinal membrane separation in highly myopic eyes with retinal detachment resulting from a macular hole
    Y Oshima
    Department of Ophthalmology, Osaka Rosai Hospital, Sakai City, Japan
    Am J Ophthalmol 126:669-76. 1998
    ..However, removing friable, thin ERMs from detached retinas is often difficult. We report the efficacy of a diamond-dusted silicone cannula in the removal of ERMs from detached retinas...
  15. pmc Trypan blue staining of internal limiting membrane and epiretinal membrane during vitrectomy: visual results and histopathological findings
    K Li
    St Paul s Eye Unit, Royal Liverpool University Hospital, UK
    Br J Ophthalmol 87:216-9. 2003
    To report on the use of trypan blue (TB) 0.06% for staining the internal limiting membrane (ILM) and epiretinal membrane (ERM) during vitrectomy and report on their histology.
  16. ncbi High prevalence of tetracycline resistance in Enterococcus isolates from broilers carrying the erm(B) gene
    K Cauwerts
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
    Avian Pathol 36:395-9. 2007
    A total of 73 isolates of Enterococcus spp. carrying the erm(B) gene were obtained from cloacal swabs of broiler chickens derived from 13 different farms in Belgium...
  17. doi A conjugative macrolide resistance gene, mef(A), in environmental Clostridium perfringens carrying multiple macrolide and/or tetracycline resistance genes
    O O Soge
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    J Appl Microbiol 106:34-40. 2009
    ..To determine if environmental Clostridium perfringens carry antibiotic resistance genes and if the genes are mobile...
  18. ncbi Development and trends of surgical modalities for breast cancer in China: a review of 16-year data
    Ke Da Yu
    Department of Breast Surgery, Cancer Hospital Cancer Institute, Fudan University, Shanghai, 200032, People s Republic of China
    Ann Surg Oncol 14:2502-9. 2007
    ..Surgery is the most important treatment for nonmetastatic breast cancer; however, the utilization of modern surgical techniques in management of breast cancer in mainland China has not been reported...
  19. pmc Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38)
    Kevin A Nash
    Children s Hospital Los Angeles and University of Southern California, Los Angeles, California, USA
    Antimicrob Agents Chemother 47:3053-60. 2003
    ..A search of the DNA sequence data for M. smegmatis strain mc(2)155 identified a novel erm gene, erm(38), and expression analysis showed that erm(38) RNA levels increased >10-fold after a 2-h incubation ..
  20. ncbi Resistance to macrolides, lincosamides, streptogramins, and linezolid among members of the Staphylococcus sciuri group
    Srdjan Stepanovic
    Department of Bacteriology, Institute of Microbiology and Immunology, School of Medicine, 11000 Belgrade, Serbia
    Microb Drug Resist 12:115-20. 2006
    ..their susceptibility by disk diffusion and agar dilution methods, along with PCR detection of the resistance genes erm(A), erm(B), erm(C), mef(A), lnu(A), and lnu(B), were performed. Resistance to macrolides was detected in 10 (5...
  21. ncbi Distribution and expression of macrolide resistance genes in coagulase-negative staphylococci
    S G Gatermann
    Abteilung für Medizinische Mikrobiologie, Ruhr Universitat Bochum, Bochum, Germany
    Clin Microbiol Infect 13:777-81. 2007
    ..Most (63%) erythromycin-resistant isolates carried constitutively expressed erm(C) as the sole resistance determinant, with the notable exception of Staphylococcus hominis subsp...
  22. pmc Molecular basis of intrinsic macrolide resistance in clinical isolates of Mycobacterium fortuitum
    Kevin A Nash
    Department of Pathology, University of Southern California, and Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA, USA
    J Antimicrob Chemother 55:170-7. 2005
    ..Some clinical isolates of Mycobacterium fortuitum are naturally resistant to macrolides, e.g. clarithromycin. Thus, the aim of this study was to identify the gene(s) conferring this resistance...
  23. ncbi Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin
    Petra Lüthje
    Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft FAL, Höltystr 10, 31535 Neustadt Mariensee, Germany
    J Antimicrob Chemother 59:97-101. 2007
    ..which are frequently used for the therapy of bovine mastitis, cannot induce the expression of the resistance gene erm(C)...
  24. pmc Assessment of clarithromycin susceptibility in strains belonging to the Mycobacterium abscessus group by erm(41) and rrl sequencing
    Sylvaine Bastian
    Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France
    Antimicrob Agents Chemother 55:775-81. 2011
    Clarithromycin was the drug of choice for Mycobacterium abscessus infections until inducible resistance due to erm(41) was described. Because M. abscessus was split into M...
  25. doi Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography
    Hideki Koizumi
    Vitreous Retina Macula Consultants of New York, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 145:509-517. 2008
    To delineate the 3-dimensional (3-D) relationship in vitreomacular traction (VMT) and idiopathic epiretinal membrane (ERM).
  26. pmc Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage
    A Tait-Kamradt
    Department of Infectious Diseases, Pfizer, Inc, Groton, Connecticut 06340, USA
    Antimicrob Agents Chemother 44:2118-25. 2000
    ..macrolides, but resistance could not be explained by any clinically relevant resistance determinant [mef(A), erm(A), erm(B), erm(C), erm(TR), msr(A), mph(A), mph(B), mph(C), ere(A), ere(B)]...
  27. ncbi Molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae and Streptococcus pyogenes isolated from the PROTEKT 1999-2000 study
    D J Farrell
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 50:39-47. 2002
    ..pneumoniae isolates collected from 25 countries were as follows: 35.3% mef(A), 56.2% erm(B), 6.8% both mef(A) and erm(B), 0.2% erm(A) subclass erm(TR) and 1.5% negative for mechanisms tested...
  28. pmc Differences in potential for selection of clindamycin-resistant mutants between inducible erm(A) and erm(C) Staphylococcus aureus genes
    Claire Daurel
    Service de Microbiologie, CHU Cote de Nacre, 14033 Caen Cedex, France
    J Clin Microbiol 46:546-50. 2008
    In staphylococci, inducible macrolide-lincosamide-streptogramin B (MLS(B)) resistance is conferred by the erm(C) or erm(A) gene. This phenotype is characterized by the erythromycin-clindamycin "D-zone" test...
  29. ncbi In vitro selection of resistance to clindamycin related to alterations in the attenuator of the erm(TR) gene of Streptococcus pyogenes UCN1 inducibly resistant to erythromycin
    M Fines
    Service de Microbiologie, CHU Cote de Nacre, Avenue Cote de Nacre, 14033 Caen Cedex, France
    J Antimicrob Chemother 48:411-6. 2001
    ..03 mg/L) harboured an inducible erm(TR) gene encoding a ribosomal methylase...
  30. ncbi Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations
    George G Zhanel
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, and Health Sciences Centre, MS673 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9
    J Antimicrob Chemother 52:83-8. 2003
    ..pneumoniae simulating clinically achievable free serum (S), epithelial lining fluid (ELF) and middle ear fluid (MEF) concentrations...
  31. ncbi Tetracycline and macrolide co-resistance in Streptococcus pyogenes: co-selection as a reason for increase in macrolide-resistant S. pyogenes?
    Hans Ulrik K Nielsen
    Statens Serum Institut, 2300 Copenhagen S, Denmark
    Microb Drug Resist 10:231-8. 2004
    ..November 2000, and November 2002. The macrolide-resistance genes, erm(B), erm(A), and mef(A) were detected in 46%, 18%, and 32% of the tested MRSP isolates, respectively...
  32. ncbi Trypan blue- and indocyanine green-assisted epiretinal membrane surgery: clinical and histopathological studies
    A K H Kwok
    Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong, People s Republic of China
    Eye (Lond) 18:882-8. 2004
    To evaluate the clinical outcome and electron microscopic findings of trypan blue (Tb) and indocyanine green (ICG) assisted epiretinal membrane (ERM) surgery.
  33. pmc Molecular epidemiologic analysis of Enterococcus faecalis isolates in Cuba by multilocus sequence typing
    Dianelys Quiñones
    Department of Bacteriology Mycology, Pedro Kouri Institute of Tropical Medicine, Havana, Cuba
    Microb Drug Resist 15:287-93. 2009
    ..of both antimicrobial resistance genes [aac(6')-aph(2''), aph(3'), ant(6), ant(3'')(9), aph(2'')-Id, aph(2'')-Ic, erm(B), erm(A), erm(C), mef(A), tet(M), and tet(L)] and virulence genes (agg, gelE, cylA, esp, ccf, and efaAfs) were ..
  34. ncbi Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy
    Eric J Feron
    Rotterdam Eye Hospital, Schiedamsevest 180, 3011 BH Rotterdam, The Netherlands
    Arch Ophthalmol 120:141-4. 2002
    To determine whether trypan blue staining facilitates epiretinal membrane (ERM) removal in proliferative vitreoretinopathy.
  35. ncbi Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm
    Stephen Douthwaite
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Mol Microbiol 58:613-22. 2005
    ..This form of resistance is encoded by erm dimethyltransferase genes, and is found in many pathogenic bacteria...
  36. ncbi New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci
    Ileana Cochetti
    Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, 60020 Ancona, Italy
    J Antimicrob Chemother 60:127-31. 2007
    To analyse the as yet unexplored genetic elements encoding erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci.
  37. doi [High-resolution optical coherence tomography to evaluate vitreomacular traction before and after membrane peeling]
    M Georgopoulos
    Universitätsklinik für Augenheilkunde und Optometrie, Medizinische Universität Wien, Wahringer Gurtel 18 20, 1090, Wien, Osterreich
    Ophthalmologe 105:753-60. 2008
    ....
  38. doi Unusual resistance patterns in macrolide-resistant Streptococcus pyogenes harbouring erm(A)
    Surbhi Malhotra-Kumar
    Department of Medical Microbiology, Vaccine and Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium
    J Antimicrob Chemother 63:42-6. 2009
    We identified erm(A)-harbouring Streptococcus pyogenes that expressed three variant phenotypes: (1) low-level resistance to erythromycin (MICs 1-4 mg/L) but high azithromycin MICs in absolute terms (16-64 mg/L; n=6); (2) same as (1) but ..
  39. doi Selected antimicrobial resistance during composting of manure from cattle administered sub-therapeutic antimicrobials
    Ranjana Sharma
    Agriculture and Agri Food Research Centre, 5403 1st Ave S, Lethbridge, Alberta, Canada T1J 4B1
    J Environ Qual 38:567-75. 2009
    ..ampicillin (Amp(r)) and tetracycline (Tet(r)), and select tetracycline (tet) and erythromycin resistance methylase (erm) genes...
  40. doi Molecular ecology of macrolide-lincosamide-streptogramin B methylases in waste lagoons and subsurface waters associated with swine production
    Satoshi Koike
    Department of Animal Sciences, University of Illinois at Urbana Champaign, 1207 W Gregory Dr, Urbana, IL 61801, USA
    Microb Ecol 59:487-98. 2010
    ..MLS(B) resistance genes found in tylosin-producing Streptomyces (tlr(B), tlr(D)) and commensal/pathogenic bacteria (erm(A), erm(B), erm(C), erm(F), erm(G), erm(Q))...
  41. doi Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream
    A Persson
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Neuroscience 167:312-22. 2010
    ..Radixin is a member of the ERM (Ezrin, Radixin, Moesin) family, which connect the actin cytoskeleton to the extracellular matrix through ..
  42. ncbi Molecular epidemiology and genetic linkage of macrolide and aminoglycoside resistance in Staphylococcus intermedius of canine origin
    P Boerlin
    Institute for Veterinary Bacteriology, University of Bern, Langgass strasse 122, CH 3012, Bern, Switzerland
    Vet Microbiol 79:155-69. 2001
    ..intermedius populations. The erythromycin-resistant isolates were all carrying erm(B), but not erm(A), erm(C), or msr(A)...
  43. doi Effect of erythromycin on biological activities induced by clostridium perfringens alpha-toxin
    Masataka Oda
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashirocho, Tokushima, Japan
    J Pharmacol Exp Ther 327:934-40. 2008
    ..Here, we show that alpha-toxin-induced lethality in mice was inhibited by i.v. preadministration of erythromycin (ERM)...
  44. pmc Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function
    Carla M K Morrow
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 81:871-9. 2009
    ..In conclusion, CLDN5 is expressed in the seminiferous epithelium, appears to be regulated by multiple influences, and contributes to BTB function...
  45. doi Vision-related quality of life and visual function after vitrectomy for various vitreoretinal disorders
    Fumiki Okamoto
    Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Invest Ophthalmol Vis Sci 51:744-51. 2010
    ..To investigate vision-related quality of life (VR-QOL) in patients undergoing vitrectomy for various vitreoretinal disorders and to evaluate the relationship between VR-QOL and visual function...
  46. doi Mycoparasitism of arbuscular mycorrhizal fungi: a pathway for the entry of saprotrophic fungi into roots
    Nathalie De Jaeger
    Earth and Life Institute, Mycology, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    FEMS Microbiol Ecol 73:312-22. 2010
    ..fungus parasitizes a wide range of phytopathogenic fungi, a phenomenon also reported in the extraradical mycelium (ERM) of AM fungi...
  47. ncbi Erythromycin resistance and virulence genes in Enterococcus faecalis from swine in China
    Li Kou Zou
    School of Life Science, Sichuan University, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, China
    New Microbiol 34:73-80. 2011
    ..the DNA from rythromycin-resistant isolates were amplified with primers specific for erythromycin resistance erm(A), erm(B), erm(C), mef(A/E), and msr(C) genes...
  48. pmc Enzymatic evidence for the key role of arginine in nitrogen translocation by arbuscular mycorrhizal fungi
    Cristina Cruz
    Universidade de Lisboa, Faculdade de Ciencias, Departamento de Biologia Vegetal, Centro de Ecologia e Biologia Vegetal, 1749 016 Lisboa, Portugal
    Plant Physiol 144:782-92. 2007
    ..petri dishes and three ammonium levels were supplied to the compartment containing the extraradical mycelium (ERM), but no roots...
  49. ncbi Prevalence of mefE, erm and tet(M) genes in Streptococcus pneumoniae strains from Central Italy
    L Latini
    Department of Pediatrics, University of Rome La Sapienza, Italy
    Int J Antimicrob Agents 13:29-33. 1999
    ..The mefE, erm and tet(M) genes were detected in 16.2, 45.1 and 47.4% of isolates respectively...
  50. ncbi Epithelial cell response to challenge of bacterial lipoteichoic acids and lipopolysaccharides in vitro
    M T Pöllänen
    Institute of Dentistry, University of Turku, Finland
    J Med Microbiol 49:245-52. 2000
    ..Porphyromonas gingivalis, Treponema denticola and Escherichia coli) on two epithelial cell lines (HaCaT and ERM) and a culture model for human JE...
  51. ncbi Genetic linkage between erm(B) and vanA in Enterococcus hirae of poultry origin
    Katrine Borgen
    Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science N 0033 Oslo, Norway
    Microb Drug Resist 8:363-8. 2002
    ..In the present study, a close genetic linkage between the vanA and erm(B) determinants in an Enterococcus hirae isolate of poultry origin is demonstrated, a result that indicates a ..
  52. ncbi Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis
    Gareth R John
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 24:2837-45. 2004
    ..interactions with focal adhesions, nonmuscle myosin, and microvillar adapter proteins of the ezrin-radixin-moesin (ERM) family...
  53. ncbi Direct detection of antibiotic resistance genes in specimens of chicken and pork meat
    Cristiana Garofalo
    Department of Food Sciences, Universita Politecnica delle Marche, Via Ranieri, Montedago, 60131 Ancona, Italy
    Int J Food Microbiol 113:75-83. 2007
    ..The frequency of 11 genes [tet(M), tet(O), tet(K), erm(A), erm(B), erm(C), vanA, vanB, aac (6')-Ie aph (2'')-Ia, mecA, blaZ] encoding resistance to some antibiotics ..
  54. ncbi Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance
    Liz Simon
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Exp Cell Res 313:3090-9. 2007
    ..In conclusion, we have identified common and unique pathways that regulate Etv5 and Gdnf mRNA in Sertoli cells, and FGFs are emerging as key regulators of the Sertoli cell proteins that control SSCs...
  55. ncbi Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era
    George L Daikos
    First Department of Propaedeutic Medicine, University of Athens, 11527 Athens, Greece
    Diagn Microbiol Infect Dis 60:393-8. 2008
    ..Susceptibilities to macrolides were determined by Etest. The presence of mef(A), mef(E), and erm(B) genes were detected by polymerase chain reaction...
  56. pmc Clonal multidrug-resistant Corynebacterium striatum strains, Italy
    Floriana Campanile
    Department of Microbiology, University of Catania, Catania, Italy
    Emerg Infect Dis 15:75-8. 2009
    ..Pulsed-field gel electrophoresis confirmed a single clone, possessing erm(X), tetA/B, cmxA/B, and aphA1 genes, but few related subclones. This strain is emerging as a pathogen in Italy.
  57. doi Molecular characterisation, antibiotic sensitivity and serotyping of hungarian Streptococcus pneumoniae isolates
    Orsolya Dobay
    Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary
    Acta Microbiol Immunol Hung 55:395-407. 2008
    ..The main underlying mechanism was the presence of the erm(B) gene, but we could find also strains with the mef gene, some of them with unusually high resistance levels...
  58. doi Possible contribution of hyalocytes to idiopathic epiretinal membrane formation and its contraction
    R i Kohno
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Br J Ophthalmol 93:1020-6. 2009
    To address the cellular components and the contractile mechanisms of the idiopathic epiretinal membrane (ERM).
  59. doi Occurrence and persistence of erythromycin resistance genes (erm) and tetracycline resistance genes (tet) in waste treatment systems on swine farms
    Jing Chen
    Department of Animal Sciences, The Ohio State University, 2029 Fyffe Road, Columbus, OH 43210, USA
    Microb Ecol 60:479-86. 2010
    ..Three classes of erythromycin resistance genes (erm) genes (B, F, and X) conferring resistances to macrolide-lincosamides-streptogramin B (MLS(B)) and one class of ..
  60. doi Sediment quality in near coastal waters of the Gulf of Mexico: influence of Hurricane Katrina
    John M Macauley
    U S Environmental Protection Agency, Gulf Ecology Division, 1 Sabin Island Drive, Gulf Breeze, Florida 32561, USA
    Environ Toxicol Chem 29:1403-8. 2010
    ..There were no exceedances of effects range median (ERM) sediment quality guideline values for chemical contaminants in any of the sediment samples collected from the Lake ..
  61. doi Gene profiling of Graffi murine leukemia virus-induced lymphoid leukemias: identification of leukemia markers and Fmn2 as a potential oncogene
    Cyndia Charfi
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Centre BIOMED, Universite du Quebec a Montreal, Montreal, QC, Canada
    Blood 117:1899-910. 2011
    ..These results, surely related to the role of FMN2 in meiotic spindle maintenance, suggest its important role in leukemogenesis. Finally, we propose a new panel of genes potentially involved in T and/or B leukemias...
  62. doi Absolute quantification of human serum transferrin by species-specific isotope dilution laser ablation ICP-MS
    Ioana Konz
    Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Julian Claveria, 8 33006 Oviedo, Spain
    Anal Chem 83:5353-60. 2011
    ..species-specific GE-LA-ICP-IDMS method was tested for the analysis of a serum certified reference material (ERM-DA470k/IFCC)...
  63. pmc Collaborative evaluation of an erythromycin-clindamycin combination well for detection of inducible clindamycin resistance in beta-hemolytic streptococci by use of the CLSI broth microdilution method
    James H Jorgensen
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Clin Microbiol 49:2884-6. 2011
    Constitutive or inducible clindamycin resistance can occur in beta-hemolytic streptococci due to the presence of an erm gene...
  64. doi The coactivator activator CoAA regulates PEA3 group member transcriptional activity
    Kathye Verreman
    Institut de Biologie de Lille, CNRS Université Lille Nord de France, Institut Pasteur de Lille, France
    Biochem J 439:469-77. 2011
    The PEA3 (polyoma enhancer activator 3) group members [ERM (ETS-related molecule), ER81 (ETS-related 81) and PEA3] of the Ets transcription factor family are involved in migration and dissemination processes during organogenesis and ..
  65. doi Association of highly and weakly mycorrhizal seedlings can promote the extra- and intraradical development of a common mycorrhizal network
    Damien Derelle
    UPMC Paris 6, CNRS UMR 7618, Paris Cedex 05, France
    FEMS Microbiol Ecol 79:251-9. 2012
    ..truncatula mycorrhizal donor plant. Extraradical mycelium (ERM) and root colonization parameters as well as root morphology were measured over a period of 12 days...
  66. ncbi Excessive expression of hippocampal ezrin is induced by intrastriatal injection of 6-hydroxydopamine
    Yosuke Matsumoto
    Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan
    Biol Pharm Bull 34:1753-8. 2011
    ..Ezrin, radixin, and moesin are collectively known as ERM proteins...
  67. doi A high prevalence of mupirocin and macrolide resistance determinant among Staphylococcus aureus strains isolated from burnt patients
    Shadi Shahsavan
    Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Burns 38:378-82. 2012
    ..Ninety five percent of the isolates were positive for one or more erm genes. The most common genes were ermA (75%), ermC (72%) and ermB (69%), respectively...
  68. doi Retinal surface en face optical coherence tomography: a new imaging approach in epiretinal membrane surgery
    Marco Rispoli
    Mediterraneo Eye Center, Rome, Italy
    Retina 32:2070-6. 2012
    To describe the clinical effectiveness of a new imaging approach: en face spectral domain optical coherence tomography of the retinal surface before and after epiretinal membrane (ERM) and internal limiting membrane peeling.
  69. doi Associations between metamorphopsia and foveal microstructure in patients with epiretinal membrane
    Fumiki Okamoto
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
    Invest Ophthalmol Vis Sci 53:6770-5. 2012
    To investigate the relationship between the severity of metamorphopsia and the foveal microstructure measured with spectral-domain optical coherence tomography (SD-OCT) in patients with epiretinal membrane (ERM).
  70. doi Heavy metal in surface sediments of the Liaodong Bay, Bohai Sea: distribution, contamination, and sources
    Bangqi Hu
    Key Laboratory of Marine Hydrocarbon Resources and Environmental Geology, Ministry of Land and Resources, Qingdao Institute of Marine Geology, Qingdao 266071, China
    Environ Monit Assess 185:5071-83. 2013
    ..The spatial distribution of ecotoxicological index (mean-ERM-quotient) suggested that most of the surface sediments were "low-medium" priority zone...
  71. doi Photoreceptor outer segment length: a prognostic factor for idiopathic epiretinal membrane surgery
    Akira Shiono
    Department of Ophthalmology, St Marianna University School of Medicine, Miyamae ku, Kawasaki, Kanagawa, Japan
    Ophthalmology 120:788-94. 2013
    To investigate prognostic factors for visual improvement in patients undergoing vitrectomy for epiretinal membrane (ERM) using spectral domain (SD) optical coherence tomography (OCT).
  72. ncbi [Correlation between the morphology of the IS/OS junction and functional outcomes in patients with idiopathic epiretinal membrane]
    Maiko Inoue
    Department of Ophthalmology, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Nippon Ganka Gakkai Zasshi 116:1029-36. 2012
    Microincision vitrectomy surgery of an idiopathic epiretinal membrane (ERM) is useful for improving vision. However, some cases show poor visual recovery even after complete removal of the ERM...
  73. doi Detection of antibiotic resistant enterococci and Escherichia coli in free range Iberian Lynx (Lynx pardinus)
    Alexandre Gonçalves
    Center of Genomics and Biotechnology Institute for Biotechnology and Bioengineering, University of Tras os Montes and Alto Douro, Vila Real, Portugal
    Sci Total Environ 456:115-9. 2013
    ..The tet(M) and/or tet(L), erm(B), aac(6')-Ie-aph(2″)-Ia, ant(6)-Ia, or aph(3')-IIIa genes were detected among resistant enterococci...
  74. doi Prevalence of inducible clindamycin resistance among community-associated staphylococcal isolates in central Serbia
    A D Aleksandra
    Public Health Institute, Kragujevac Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia
    Indian J Med Microbiol 32:49-52. 2014
    ..Detection of inducible clindamycin resistance was performed by the D-test, while the presence of methylases genes: erm (A), erm (B) and erm (C), as well as, macrolide efflux gene mef was determined by polymerase chain reaction...
  75. pmc Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton
    Min Ma
    Neuro Oncology, Experimental Infectious Diseases and Cancer Research, University Children s Hospital Zurich, Zurich, Switzerland Molecular Pathobiology, University of Bern, Bern, Switzerland Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland
    PLoS Pathog 10:e1004003. 2014
    ..We identified the F-actin binding ERM family proteins as MAP4K4 downstream effectors in this process because TNFα-induced ERM activation and cell ..
  76. ncbi First clinical isolate in Europe of clindamycin-resistant group B Streptococcus mediated by the lnu(B) gene
    David M Arana
    Juan Ignacio Alós, Servicio de Microbiologia, Hospital Universitario de Getafe, Madrid, Spain
    Rev Esp Quimioter 27:106-9. 2014
    ..The presence of macrolide or lincosamide resistance genes [erm(A), erm(B), erm(C), erm(T), mef(A), mrs(A), lnu(A), lnu(B), lsa(B), lsa(C) and vga(C)] was investigated by PCR and ..
  77. doi Analysis of the ganglion cell layer and photoreceptor layer using optical coherence tomography after idiopathic epiretinal membrane surgery
    Sung Who Park
    Department of Ophthalmology, School of Medicine, Pusan National University, Yangsan, Korea
    Graefes Arch Clin Exp Ophthalmol 253:207-14. 2015
    To investigate the correlation of visual acuity with the ganglion cell layer and the photoreceptor layer using spectral-domain optical coherence tomography after surgery for idiopathic epiretinal membrane (ERM).
  78. pmc Ezrin silencing remodulates the expression of Phosphoinositide-specific Phospholipase C enzymes in human osteosarcoma cell lines
    V R Lo Vasco
    Sense organs Department, Policlinico Umberto I Faculty of Medicine and Dentistry, Sapienza University of Rome, Viale del Policlinico 155, 00185, Italy, Rome
    J Cell Commun Signal 8:219-29. 2014
    Ezrin, a protein belonging to the Ezrin, radixin and moesin (ERM) family, was engaged in the metastatic spread of osteosarcoma. The Protein 4...
  79. doi p38MAPK, Rho/ROCK and PKC pathways are involved in influenza-induced cytoskeletal rearrangement and hyperpermeability in PMVEC via phosphorylating ERM
    Chenyue Zhang
    Department of Microbiology and Immunology, Beijing University of Chinese Medicine, Beijing, PR China
    Virus Res 192:6-15. 2014
    ..Studies have also shown that ERM is phosphorylated in response to various stimuli via p38MAPK, Rho/ROCK or PKC pathways...
  80. doi Determination of Cystatin C in human serum by isotope dilution mass spectrometry using mass overlapping peptides
    Ana González-Antuña
    Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Julian Claveria 8, 33006 Oviedo, Spain
    J Proteomics 112:141-55. 2015
    ..Applicability of the approach is demonstrated by the measurement of the serum concentration of Cystatin C in Reference Material ERM R-DA471/IFCC and real samples.
  81. pmc Intraoperative and fluorescein angiographic findings of a secondary macular hole associated with age-related macular degeneration treated by pars plana vitrectomy
    Tomohiro Okamoto
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Ophthalmol 14:114. 2014
    ..Although exudative changes derived from CNV may cause epiretinal membrane (ERM) formation, which can also cause tractional force at the vitreo-retinal interface, there have been few reports of ..
  82. doi Occurrence, distribution, and ecological risk assessment of potentially toxic elements in surface sediments of Lake Awassa and Lake Ziway, Ethiopia
    Kebede N Mekonnen
    a Department of Chemistry, Addis Ababa University, Addis Ababa, Ethiopia
    J Environ Sci Health A Tox Hazard Subst Environ Eng 50:90-9. 2015
    ..Based on effect range low (ERL) - effect range medium (ERM), in both lakes for Ag were greater than the ERM, indicating that the areas could be toxic to aquatic organisms, ..
  83. doi Diversity of enterococcal species and characterization of high-level aminoglycoside resistant enterococci of samples of wastewater and surface water in Tunisia
    Leila Ben Said
    Laboratoire de Microorganismes et Biomolecules Actives, Departement de Biologie, Faculté de Sciences de Tunis, Campus Universitaire, 2092 Tunis, Tunisia
    Sci Total Environ 530:11-7. 2015
    ..gene (number isolates)]: kanamycin [29%/aph(3')-IIIa (n=22)], streptomycin [8%/ant(6)-Ia (n=4)], erythromycin [44%/erm(B) (n=34)], tetracycline [18%/tet(M) (n=6)/tet(M)-tet(L) (n=9)], chloramphenicol [2%/cat(A) (n=1)], ciprofloxacin [..
  84. doi Distribution and ecotoxicology of bioavailable metals and As in surface sediments of Paraguaçu estuary, Todos os Santos Bay, Brazil
    Taís de S Pereira
    Núcleo de Estudos Ambientais, Instituto de Geociencias, Universidade Federal da Bahia UFBA, Campus de Ondina, 40170 290 Salvador, BA, Brazil
    Mar Pollut Bull 99:166-77. 2015
    ..Pollution indices (EF, Igeo and PIN) and a comparison with sediment quality guidelines (UET, ERL, ERM, TEL and PEL of NOAA) were conducted in order to evaluate the potential metal impacts over the area...
  85. pmc Antimicrobial Susceptibility of Autochthonous Aquatic Vibrio cholerae in Haiti
    Sandrine Baron
    Mycoplasmology Bacteriology Unit, Ploufragan Plouzane Laboratory, French Agency for Food, Environmental and Occupational Health and SafetyPloufragan, France Vie Agro Santé, Bretagne Loire UniversityRennes, France
    Front Microbiol 7:1671. 2016
    ..Among the 50 isolates, 78% possessed at least two resistance-associated genes, and the genes sul1, ermA, and strB were detected in all four multidrug-resistant isolates...
  86. pmc High rate of transmission of penicillin-resistant Streptococcus pneumoniae between parents and children
    Kazuhiko Hoshino
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Clin Microbiol 40:4357-9. 2002
    ..protein genes pbp1a, pbp2x, and pbp2b and 33 strains had macrolide resistance genes mef(A) and/or erm(B). As a result, the PCR patterns of 16 of 18 pairs were identical...
  87. pmc Novel genomic rearrangement that affects expression of the Streptococcus pyogenes streptolysin O (slo) gene
    Dragutin J Savic
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Bacteriol 185:1857-69. 2003
    ..region, the reproducibility of the rearrangement, and the fact that reconstructed recombinant molecules fused to erm and lacZ reporter genes affected their expression indicate that this event is not accidental but may play a role in ..
  88. ncbi Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering
    Aleksandar Ivetic
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS United Kingdom
    J Biol Chem 279:33263-72. 2004
    ..two basic amino acid residues within the L-selectin tail that are required for binding to ezrin-radixinmoesin (ERM) proteins: arginine 357 and lysine 362...
  89. ncbi Macrolide resistance based on the Erm-mediated rRNA methylation
    G Maravić
    Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovacicća 1, 10000 Zagreb, Croatia
    Curr Drug Targets Infect Disord 4:193-202. 2004
    ..practice is the modification of the target site exhibited by a family of rRNA methyltransferases designated Erm. Using S-adenosyl-L-methionine, Erm enzymes catalyze mono- or dimethylation of a specific adenine residue in the ..
  90. ncbi [Expression of ETV5 and MMP-7 in early stage cervical squamous cell carcinoma and its role in lymphatic metastasis]
    Su Hui Wu
    Department of Gynecology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P R China
    Ai Zheng 25:315-9. 2006
    ..This study was to investigate the expression of ETV5 and MMP-7 in cervical squamous cell carcinoma, and explore the roles of ETV5 and MMP-7 in invasion and metastasis of early stage cervical squamous cell carcinoma...
  91. doi The prevalence of erythromycin resistance in group B streptococcal isolates at a University Hospital in Taiwan
    Rajendra Prasad Janapatla
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan
    Microb Drug Resist 14:293-7. 2008
    ..Percentage of erythromycin-resistant isolates with erm(B) gene significantly increased from 72% in 2001 to 90% in 2007...
  92. pmc Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Antimicrob Agents Chemother 53:4240-6. 2009
    ..The vanA gene cluster and gentamicin resistance determinants were genetically linked to hyl(Efm), whereas erm(B) and ant(6)-I, conferring macrolide-lincosamide-streptogramin B resistance and HLR to streptomycin, respectively, ..
  93. doi Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells
    Isabelle Cornez
    The Biotechnology Centre of Oslo, Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, Oslo, Norway
    FEBS Lett 584:2681-8. 2010
    ..PKA and Csk by forming a supramolecular signaling complex consisting of PKA, Ezrin, Ezrin/radixin/moesin (ERM) binding protein of 50 kDa (EBP50), phosphoprotein associated with glycosphingolipid-enriched membrane microdomains ..
  94. doi Phylogenetic analysis of rRNA methyltransferases, Erm and KsgA, as related to antibiotic resistance
    Ae Kyung Park
    Department of Biomedical Sciences, Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea
    FEMS Microbiol Lett 309:151-62. 2010
    It has long been speculated that erm and ksgA are related evolutionarily due to their sequence similarity and analogous catalytic reactions...
  95. doi Comparative susceptibility of Atlantic salmon and rainbow trout to Yersinia ruckeri: relationship to O antigen serotype and resistance to serum killing
    Sarah J Haig
    CEFAS Weymouth Laboratory, The Nothe, Barrack Road, Weymouth, Dorset DT4 8UB, UK
    Vet Microbiol 147:155-61. 2011
    ..Isolate 06041, a typical ERM-causing serotype O1 UK rainbow trout strain, caused mortalities in both rainbow trout and salmon...
  96. doi ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells
    Ming Ou-Yang
    School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, China
    Biochimie 93:954-61. 2011
    Three closely related proteins, ezrin, radixin, and moesin (ERM), which primarily act as a linker between the plasma membrane and the cytoskeleton, are involved in many cellular functions, including regulation of actin cytoskeleton, ..
  97. pmc Ezrin-mediated apical integrity is required for intestinal homeostasis
    Jessica B Casaletto
    Massachusetts General Hospital Center for Cancer Research and Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 108:11924-9. 2011
    ..The Ezrin, Radixin, and Moesin (ERM) proteins play a major role in organizing cortical domains by assembling membrane protein complexes and linking ..
  98. doi Significant, quantifiable differences exist between IgG subclass standards WHO67/97 and ERM-DA470k and can result in different interpretation of results
    Calum Wilson
    Binding Site Group Limited, 8 Calthorpe Road, Birmingham B15 1QT, United Kingdom
    Clin Biochem 46:1751-5. 2013
    ..We expand on previous reports and present data from a multi-site analysis that both identifies and quantitatively defines the differences in calibration resulting from the use of different reference materials...
  99. doi PDLLA/PRGD/β-TCP conduits build the neurotrophin-rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration
    Tong Qiu
    Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan, 430070, People s Republic of China
    J Biomed Mater Res A 102:3734-43. 2014
    ..8 folds), tubulin (5.6 folds), and ERM components expressions were observed later (35 days)...
  100. pmc Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
    Soraia Barão
    VIB Center for the Biology of Disease, VIB Leuven 3000, Belgium Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU Leuven, Leuven 3000, Belgium
    Cell Rep 12:1367-76. 2015
    ..This fragment relays the Sema3A signal via ezrin-radixin-moesin (ERM) proteins to the neuronal cytoskeleton...
  101. doi Antimicrobial resistance and population structure of Staphylococcus aureus recovered from pigs farms
    Laura E J Peeters
    Department of Bacterial Diseases, Veterinary and Agrochemical Research Centre, Brussels, Groeselenbergstraat 99, B 1180 Ukkel, Belgium Department of Pathology, Bacteriology, and Avian Diseases, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Microbiol 180:151-6. 2015
    ..isolates carried genes encoding resistance to tetracycline [tet(M)], macrolide-lincosamide-streptogramin group [erm(B), erm(C), lnu(A), vga(A)], aminoglycosides (aacA-aphD,aa dD, aphA3, sat) and/or phenicols (fexA)...

Research Grants72

  1. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
    ..The long -erm goals of this research include improvement of the survival outcome, prevention of relapse, easier therapeutic ..
  2. Mechanisms of macrolide resistance in mycobacteria
    Kevin A Nash; Fiscal Year: 2010
    ..is conferred by 23S rRNA gene mutation, intrinsic resistance involves expression of adenine rRNA methylases, or erm genes...
  3. Mechanism of Induction of erm Genes By Ketolide Antibiotics
    Nora Vazquez Laslop; Fiscal Year: 2010
    ..of the major resistance mechanism found in pathogenic strains is modification of the drug-target, the ribosome, by Erm methyltransferase enzymes. The expression of many of the erm genes, including ermC, is inducible by macrolides...
  4. Role of the Listeria protein InlC and its host ligand Tuba in cell-cell spread
    KEITH PATRICK IRETON; Fiscal Year: 2009
    ..Importantly, InlC promotes activation (phosphorylation) of host ERM proteins, a family of cytoskeletal regulatory proteins known to participate in Listeria-induced protrusion ..
  5. Filippo G Giancotti; Fiscal Year: 2014
    ..The Ezrin Radixin Moesin (ERM) protein Merlin, encoded by the tumor suppressor gene NF2, localizes at the plasma membrane and mediates contact ..
  6. Molecular Mechanism of cell-cell spread of Listeria in polarized epithelial cells
    KEITH PATRICK IRETON; Fiscal Year: 2013
    ..application, outlined below, are directed towards understanding how InlC, Tuba, and the ligands N-WASP, Cdc42, and ERM proteins control cell-cell spread. AIM 1...
  7. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..We have previously reported that ezrin, a member of the ezrin-radixin-moesin (ERM) family regulates membrane-cytoskeletal uncoupling in response to B cell antigen receptor (BCR) stimulation...
  8. FRANKLIN D COSTANTINI; Fiscal Year: 2014
    ..Lack of Adamts16 and/or 18 may cause reduced nephron number and hyper- tension. We test this by examining kidney development, nephron number and blood pressure in mutant mice. ..
  9. Regulation of glioblastoma migration by PTEN PDZ-binding domain
    Andrew M Chan; Fiscal Year: 2010
    ..between the PI3-K signaling cascade involving PTEN, and a group of pro-metastatic proteins, Ezrin-Radixin-Moesin (ERM), in regulating the motile behavior of glioblastoma...
  10. MECHANISMS OF NERVE GROWTH CONE TURNING AND BRANCHING
    Paul C Letourneau; Fiscal Year: 2013
    ..The aims of this proposal are to investigate the roles and necessity of ADF/cofilin, the Arp2/3 complex, and ERM proteins in the regulation of growth cone behaviors...
  11. Erle S Robertson; Fiscal Year: 2016
    ..nuclear antigen (LANA) is constitutively expressed in all latently infected KSHV cells and is involved in the long erm maintenance of the dsDNA KSHV genome as well as transcriptional regulation...
  12. Amnon Altman; Fiscal Year: 2015
    ..analysis of proteins binding the phospho-ITAM motif of SLAT and co-immunoprecipitation experiments identified the ERM protein ezrin as a SLAT-interacting protein...
  13. Functional analysis of ERM proteins in epithelial morphogenesis
    Andrea I McClatchey; Fiscal Year: 2013
    ..The Ezrin, Radixin, Moesin (ERM) proteins organize a key role in this process...
  14. Activation Defects in T Cells of Aged Mice
    Richard A Miller; Fiscal Year: 2011
    ..the synapse to the DPC, and (b) that the cytoskeletal defect involves altered phosphorylation of proteins in the ERM family...
  15. Qun Lu; Fiscal Year: 2014
    ..Specific aim 1 will investigate two potential molecular mechanisms (ERM protein activation and redistribution to actin to activate Fas receptor/CD95 and SRF-dependent gene transcription) ..
  16. Zhenyu Yue; Fiscal Year: 2015
    ..kinase activity, and in mouse brain LRRK2 kinase is responsible for the phosphorylation of Erzin/Radixin/Moesin (ERM), an event that is associated with spine morphogenesis...
  17. KillerRed Assisted Mutagenesis to discover cancer drug resistance genes
    Daniel G Jay; Fiscal Year: 2013
    ..There are several components to KRAM: first, enhanced retroviral mutagenesis (ERM) will be used to introduce a regulated promoter/guest exon fusion encoding the photosensitizer gene, KillerRed, ..
  18. Biochemistry of ETS Factors Involved in Prostate Cancer
    Krista D Meyer; Fiscal Year: 2010
    ..Both of these interfaces are important to understand from an ETS family perspective, but can also be exploited for rational drug design in the treatment of prostate cancer. ..
  19. NHERF-1 and PTH regulation of the renal transport of phosphate.
    Edward J Weinman; Fiscal Year: 2012
    ..Regulatory Factor-1 (NHERF-1) is an adaptor protein containing two protein-interactive PDZ domains and a C-terminal ERM binding domain that localizes to the brush border membrane of renal proximal convoluted tubule cells and binds to ..
  20. Andrea I McClatchey; Fiscal Year: 2014
    ..The neurofibromatosis type 2 (NF2) tumor suppressor, Merlin, and closely related ERM proteins (Ezrin, Radixin and Moesin), localize to the membrane-cytoskeleton interface and are poised to organize ..
  21. Jennifer D Black; Fiscal Year: 2016
    ..open conformation thereby permitting its binding to a protein called EBP50 which is critical for the recruitment of ERM proteins that enable AKT signaling at the membrane...
  22. VERENA GOBEL; Fiscal Year: 2016
    ..We have shown that erm-1, the ancestral ortholog of the putative membrane-cytoskeleton linking ezrin, radixin, moesin (ERM) family, is ..
  23. Cheng Yu Lee; Fiscal Year: 2014
    ..We identified a novel transcription factor Earmuff (Erm), which restricts proliferation and suppresses de-differentiation of mature secondary neuroblasts...
  24. Regulation and function of cdk5 and ezrin in senescence
    Philip W Hinds; Fiscal Year: 2010
    ..We have further discovered that one substrate for cdk5 in senescent cells is the ERM protein ezrin...
  25. Chronic hypoxia and pH homeostasis in pulmonary myocytes
    Larissa A Shimoda; Fiscal Year: 2013
    ..NHE1 co-localizes with and binds to ezrin, a member of the ERM (ezrin/radixin/moesin) family of proteins, which contain multiple binding domains and are important mediators of ..
  26. Molecuar Sub-typing of Prostate Cancer Based on Recurrent Gene Fusions
    Arul M Chinnaiyan; Fiscal Year: 2013
    ..This proposal is about using these "gene fusions" to identify prognostic categories to improve approaches to the treatment of prostate cancer patients. ..
  27. Regulation of Renal Phosphate Transport by Lipids
    Moshe Levi; Fiscal Year: 2013
    ..and clustering of the NaPi transporters in the brush border membrane;2) differential interactions with PDZ and ERM domain containing proteins, including NHERF-1, PDZK-1, and ezrin;3) differential rates of recruitment to endocytic ..
  28. James M Swanson; Fiscal Year: 2016
    ..in dose is typically needed to maintain full effect, and there is a little support in the literature for long-erm benefit even when medication is consistently taken over a decade...
  29. Daniel L Altschuler; Fiscal Year: 2016
    ..Using thyroid cells we identified a new sub-membrane compartment, where the ERM protein radixin scaffolds both cAMP effectors Epac and PKA into a ternary complex...
  30. NF2 BINDING PROTEINS
    Stefan Pulst; Fiscal Year: 2000
    ..Other than its function as a recessive tumor suppressor based on genetic analyses and sequence homology to ERM proteins, little is known about the function of the NF2 gene product, called merlin or schwannomin...
  31. The Role of Merlin Phosphorylation on its Tumor Suppressive Activity
    Keqiang Ye; Fiscal Year: 2010
    ..1 family (ERM proteins) of cytoskeleton-associated proteins that link cell surface glycoproteins to the actin cytoskeleton...
  32. The NF2 gene: elucidation of tumor suppressor function
    JOSEPH KISSIL; Fiscal Year: 2004
    ..The NF2 gene codes for a protein highly related to the ERM proteins moesin, ezrin and radixin and was thus termed merlin...
  33. Mechanisms of Axon Outgrowth and Targeting
    Deanna L Benson; Fiscal Year: 2010
    ..we have found that the cell adhesion molecule L1 can bind directly to ezrin, radixin and moesin, members of the ERM family of molecules that link transmembrane proteins to the actin cytoskeleton...
  34. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Raphael Clynes; Fiscal Year: 2009
    ..Among these proteins are moesin, a member of the ERM family of actin-binding proteins and Abpl, an adaptor for F-actin, and dynamin...
  35. NEUROFIBROMATOSIS 2 TUMOR SUPPRESSOR GENE HOMOLOG IN
    VERENA GOBEL; Fiscal Year: 2001
    ..NF2 is structurally related to the ezrin-radixin-moesin (ERM) family of cell junctional cytoskeletal membrane-linker proteins...
  36. ATP in Lung Endothelial Barrier Enhancement
    Alexander Verin; Fiscal Year: 2009
    ..increase in TER and lead to phosphorylation of several cytoskeletal targets includingMLC, ezrin/radixin/moezin (ERM) and caldesmon suggesting that dephosphorylation of these proteins may be involved in the barrier-enhancing effect ..
  37. Genetic Interactions at the Cortical Striatal Border
    Laura A Cocas; Fiscal Year: 2010
    ..We hypothesize that the Ets family transcription factors (Er81 and Erm) and the secreted molecules Tgfa and Fgf7 are genetic downstream targets of the Gsh2/Pax6 patterning events that ..
  38. Pea3 and Erm Function during Ureteric Bud Branching Morphogenesis
    QUENTIN MACHINGO; Fiscal Year: 2007
    ..Furthermore, GDNF was found to regulate the expression of two transcription factors, Pea3 and Erm. Both Pea3 and Erm have been identified as critical for proper UB branching morphogenesis, yet the specific ..
  39. The Role of ERM Proteins in Axonal Development
    CYRUS MINTZ; Fiscal Year: 2005
    Ezrin, radixin, and moesin, collectively known as the ERM proteins, serve as linkers between the membrane associated molecules and the underlying cytoskeleton...
  40. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    James Lopez; Fiscal Year: 2009
    ..dynamic translocation of channels and other signaling molecules in glucose stimulated insulin secretion, such as ERM proteins...
  41. SCAFFOLDING COMPLEXES AND ION TRANSPORT IN AIRWAY
    Sharon Milgram; Fiscal Year: 2004
    ..SFK Yes is compartmentalized at the apical membrane by indirect interaction with the subapical scaffolding protein ERM phosphoprotein 50 (EBP50) that also associates with Cystic Fibrosis transmembrane regulator (CFTR) and ENaC...
  42. ANALYSIS OF THE HDLG-DEPENDENT PROTEIN COMPLEX
    Daniel Branton; Fiscal Year: 2001
    ..1/ERM proteins and the role of this interaction in targeting to the membrane; (2) quantifying and refining the ..
  43. The Role of Connexin32 in the Pathogenesis of CMTX
    Steven Scherer; Fiscal Year: 2006
    ....
  44. Axonal alterations in demyelinating diseases
    STEVEN SIMON SCHERER; Fiscal Year: 2011
    ..Aim #3: What Na,K-ATPase isoforms are expressed by myelinated axons and demyelinated axons? we will localize alpha1-3 by immunoelectron microscopy in CMSand PNS myelinated axons, along with their beta subunits. ..
  45. ANTIBIOTIC INHIBITION OF BACTERIAL RIBOSOME FORMATION
    WILLIAM CHAMPNEY; Fiscal Year: 2002
    ..The findings from this work will help in assessing the effectiveness of existing antibiotics and in developing new compounds as antimicrobial agents. ..
  46. Detection and Recogniton of Objects in Visual Cortex
    Tomaso Poggio; Fiscal Year: 2006
    ..Ultimately, the whole process should lead to a better and more coherent understanding of the neural mechanisms of visual recognition. ..
  47. Neurofibromatosis Foundation International Consortium
    David Gutmann; Fiscal Year: 2003
    ..abstract_text> ..
  48. Functions of the Epithelial Septate Junction
    Richard Fehon; Fiscal Year: 2009
    ..abstract_text> ..
  49. Vitamin D Hormone: Function and Mechanism of Action
    SYLVIA S CHRISTAKOS; Fiscal Year: 2010
    ....
  50. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2001
    ..Finally, new types of mutants and transgenic mice will be generated to study the role of Fused in mouse embryogenesis. ..
  51. Consortium/Molecular and Cell Biology of NF1 and NF2
    Richard Fehon; Fiscal Year: 2002
    ..abstract_text> ..
  52. PROTEIN 4.1 TUMOR SUPPRESSORS IN MENINGIOMA PATHOGENESIS
    David Gutmann; Fiscal Year: 2003
    ..and (3) analyzing the ability of DAL-1 to impair cell growth and motility. These studies are collectively designed to define the role of this novel family of growth regulators in meningioma tumorigenesis and progression. ..
  53. Identification and Preclinical Evaluation of New Brain Tumor Therapies
    David Gutmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. 2008 Bioanalytical Sensors Gordon Research Conference
    Chris Taitt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. ERM and Rho Signal Pathways in T Cell Immune Senescence
    GONZALO GARCIA; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Cytoskeletal proteins of the ezrin/radixin/moesin family (ERM proteins) contribute to T cell activation in responses to antigen, and also to T cell polarization in response to connective ..
  56. The Role of Actomyosin in Response to Injury and Myelin
    Gianluca Gallo; Fiscal Year: 2004
    ..Collectively, these studies will determine whether the actomyosin system is a viable target for the development of therapies aimed at the inhibition of nerve fiber retraction in injured nervous tissue. ..
  57. Connecting PTEN and NF2 cancer predisposition syndromes
    Maria Magdalena Georgescu; Fiscal Year: 2009
    ..abstract_text> ..
  58. Mechanisms of filopodia initiation and actin transport
    Gianluca Gallo; Fiscal Year: 2009
    ..We present studies aimed at determining the role of extra-cellular signals, signaling pathways, and microtubules in regulating the earliest events in filopodial initiation. ..
  59. NEUROFIBROMIN AS A NEGATIVE REGULATOR FOR ASTROCYTES
    David Gutmann; Fiscal Year: 2002
    ....
  60. FUNCTIONAL ANALYSIS OF NF2 GENE MUTATIONS
    David Gutmann; Fiscal Year: 2003
    ..Our ability to design rational therapies for schwannomas and meningiomas is dependent on an improved understanding of the mechanisms by which loss of merlin expression and function promotes tumor formation. ..
  61. Organ lumen morphogenesis in C. elegans
    VERENA GOBEL; Fiscal Year: 2004
    ..We have recently identified the first effector molecule essential for tube and lumen morphogenesis. erm-1, the C...
  62. NOVEL CELLULAR MECHANISMS IN CORTEX DEVELOPMENT
    Paul Worley; Fiscal Year: 2004
    ..Planned activities make full use of the outstanding opportunities for collaboration and career development at Johns Hopkins School of Medicine. ..
  63. Paul F Worley; Fiscal Year: 2016
    ..Studies of mGluR-TRPC channel function may also provide insight into the elusive role of intracellular Ca stores in neuronal synaptic physiology. ..
  64. REGULATION OF SMC/RMUC4 TRANSCRIPTION BY CELL SIGNALING
    Aymee Perez; Fiscal Year: 2004
    ..abstract_text> ..
  65. Molecular Determinants of Neural Stem Cell Function
    David Gutmann; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  66. PRECLINICAL MODELS FOR HUMAN ASTROCYTOMAS
    David Gutmann; Fiscal Year: 2004
    ..abstract_text> ..
  67. Genetic Influence on Personality Disorder
    Jeanette Taylor; Fiscal Year: 2004
    ..abstract_text> ..
  68. CHARACTERIZATION OF TSC PROTEIN HAMARTIN AND TUBERIN
    Vijaya Ramesh; Fiscal Year: 2005
    ..The information obtained here will elucidate the physiological functions of these tumor suppressors, which will aid in designing better therapies. ..
  69. 2006 Environmental Endocrine Disruptors Gordon Conference
    Rex Hess; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  70. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2007
    ..abstract_text> ..
  71. 2006 NF Consortium for NF1, NF2 and Schwannomatosis
    Vijaya Ramesh; Fiscal Year: 2006
    ..This will promote to the research community at large the status of NF research, the link with other cancers and neurological disorders and the key barriers to be addressed. [unreadable] [unreadable] [unreadable]..
  72. Cytokine regulation of glial reactivity
    Gareth John; Fiscal Year: 2007
    ..unreadable] [unreadable]..