ERK2

Summary

Gene Symbol: ERK2
Description: mitogen-activated protein kinase 1
Alias: ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, mitogen-activated protein kinase 1, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 2, extracellular signal-regulated kinase 2, mitogen-activated protein kinase 2, protein tyrosine kinase ERK2
Species: human

Top Publications

  1. pmc Human chorionic gonadotropin β induces migration and invasion via activating ERK1/2 and MMP-2 in human prostate cancer DU145 cells
    Zongwen Li
    Department of Epidemiology and Health Statistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China
    PLoS ONE 8:e54592. 2013
  2. ncbi Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
    K N Dalby
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Scotland, United Kingdom
    J Biol Chem 273:1496-505. 1998
  3. doi The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFR amplification
    Concha Lopez-Gines
    Department of Pathology, University of Valencia, Valencia, Spain
    Neuropathology 28:507-15. 2008
  4. ncbi Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells
    Sean R Conner
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 278:34548-54. 2003
  5. pmc Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
    Tomas Vomastek
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Mol Cell Biol 28:6954-66. 2008
  6. ncbi cPLA2 is phosphorylated and activated by MAP kinase
    L L Lin
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 72:269-78. 1993
  7. pmc Basal p38 mitogen-activated protein kinase regulates unliganded glucocorticoid receptor function in airway smooth muscle cells
    Belaid Bouazza
    1 Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, Pennsylvania and
    Am J Respir Cell Mol Biol 50:301-15. 2014
  8. ncbi MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
    H Sun
    Cold Spring Harbor Laboratory, New York 11724 2208
    Cell 75:487-93. 1993
  9. doi NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production
    Yi Qun Kuang
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Eur J Immunol 42:299-310. 2012
  10. pmc Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3
    Angela M Whetzel
    Cardiovascular Research Center, Univ of Virginia, P O Box 801394, 415 Lane Rd, MR5 Rm G123, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 296:C339-45. 2009

Research Grants

  1. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
  2. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John M Kyriakis; Fiscal Year: 2010
  3. Jin Kyung Kim; Fiscal Year: 2016
  4. Emilio B Gonzalez; Fiscal Year: 2014
  5. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
  6. Estrogen receptor, p38 MAPKs and topo IIa in breast cancer
    Guan Chen; Fiscal Year: 2013
  7. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
  8. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
  9. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
  10. The Role of Xanthine Oxidoreductase in Ventilator-Associated Lung Injury
    Paul M Hassoun; Fiscal Year: 2013

Detail Information

Publications270 found, 100 shown here

  1. pmc Human chorionic gonadotropin β induces migration and invasion via activating ERK1/2 and MMP-2 in human prostate cancer DU145 cells
    Zongwen Li
    Department of Epidemiology and Health Statistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China
    PLoS ONE 8:e54592. 2013
    ..These results indicated that hCGβ induced cell motility via promoting ERK1/2 phosphorylation and MMP-2 upregulation in human prostate cancer DU145 cells...
  2. ncbi Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
    K N Dalby
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Scotland, United Kingdom
    J Biol Chem 273:1496-505. 1998
    ..Ser222, Ser364, and Ser381 are situated in analogous positions to phosphorylation sites in protein kinase B, protein kinase C, and p70S6K, suggesting a common mechanism of activation for these growth factor-stimulated protein kinases...
  3. doi The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFR amplification
    Concha Lopez-Gines
    Department of Pathology, University of Valencia, Valencia, Spain
    Neuropathology 28:507-15. 2008
    ..However, the activation of ERK1/2 also involves pathways that are independent of the EGFR...
  4. ncbi Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells
    Sean R Conner
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 278:34548-54. 2003
    ..These results indicate that alterations in the adhesion requirement for ERK1/2 signaling in melanocytes are associated with the acquisition of malignant cell behavior...
  5. pmc Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
    Tomas Vomastek
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Mol Cell Biol 28:6954-66. 2008
    ..In previous work, we identified several new candidate substrates for the MAPK ERK2 (extracellular signal-regulated kinase 2), including the nuclear pore complex protein Tpr (translocated promoter ..
  6. ncbi cPLA2 is phosphorylated and activated by MAP kinase
    L L Lin
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 72:269-78. 1993
    ..Taken together, these data indicate that MAP kinase mediates, at least in part, the agonist-induced activation of cPLA2...
  7. pmc Basal p38 mitogen-activated protein kinase regulates unliganded glucocorticoid receptor function in airway smooth muscle cells
    Belaid Bouazza
    1 Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, Pennsylvania and
    Am J Respir Cell Mol Biol 50:301-15. 2014
    ..Because p38 mitogen-activated protein kinase (MAPK) directly phosphorylates GR in different cell types in a stimulus- and cell-..
  8. ncbi MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
    H Sun
    Cold Spring Harbor Laboratory, New York 11724 2208
    Cell 75:487-93. 1993
    ..factor-inducible gene, 3CH134, encodes a dual specificity phosphatase that dephosphorylates and inactivates p42MAPK both in vitro and in vivo. In vitro, 3CH134 protein dephosphorylates both T183 and Y185 in p42MAPK...
  9. doi NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production
    Yi Qun Kuang
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Eur J Immunol 42:299-310. 2012
    ..Here, we show that NHERF1 can associate with CCR5, and promote activation of the gp120-induced MAPK/ERK, focal adhesion kinase and RhoA (Ras homolog gene family member A) signaling pathways...
  10. pmc Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3
    Angela M Whetzel
    Cardiovascular Research Center, Univ of Virginia, P O Box 801394, 415 Lane Rd, MR5 Rm G123, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 296:C339-45. 2009
    ..Thus, one mechanism for the anti-inflammatory action of S1P in diabetic EC is inhibition of ERK1/2 phosphorylation through induction of MKP-3 expression via the S1P-S1P(1) receptor axis...
  11. ncbi Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
    A V Khokhlatchev
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas 75235 9041, USA
    Cell 93:605-15. 1998
    The MAP kinase ERK2 is widely involved in eukaryotic signal transduction. Upon activation it translocates to the nucleus of the stimulated cell, where it phosphorylates nuclear targets...
  12. ncbi MAP kinase protects G protein-coupled receptor kinase 2 from proteasomal degradation
    Juliane Theilade
    The Laboratory of Molecular and Cellular Cardiology, Department of Medicine B, Copenhagen University Hospital B9312, 20, Juliane Mariesvej, DK 2100 Copenhagen, Denmark
    Biochem Biophys Res Commun 330:685-9. 2005
    ..Further, ERK blockade had no effect on GRK2 synthesis as probed using a reporter construct carrying the GRK2 promoter upstream ..
  13. pmc Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    Philippe P Roux
    Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13489-94. 2004
    ..Together, our data unveil a regulatory mechanism by which the Ras/MAPK and PI3K pathways converge on the tumor suppressor tuberin to inhibit its function...
  14. pmc Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway
    Shin Ichi Yokota
    Department of Microbiology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Infect Immun 78:468-76. 2010
    ..H. pylori LPS may be a pathogenic factor causing gastric tumors by enhancing cell proliferation and inflammation via the MEK1/2-ERK1/2 mitogen-activated protein kinase cascade in gastric epithelial cells...
  15. doi Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes
    Ha Yong Song
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Free Radic Biol Med 50:576-84. 2011
    ..siRNA decreased HIV-1 Tat-induced NF-κB activation as well as activation of MAP kinases including ERK, JNK, and p38. These data indicate that Nox2-based NADPH oxidase is responsible for HIV-1 Tat-induced generation of ROS and plays ..
  16. ncbi The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells
    John K G Crean
    Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    J Biol Chem 277:44187-94. 2002
    ....
  17. ncbi Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2
    Akira Imasato
    Gonda Department of Cell and Molecular Biology, House Ear Institute, and the Department of Otolaryngology, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 277:47444-50. 2002
    ..up-regulation of the MAPK phosphatase-1 (MKP-1) that, in turn, leads to dephosphorylation and inactivation of p38 MAPK, the negative regulator for TLR2 expression...
  18. ncbi HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling
    Milan Fiala
    Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA 90095 1760, USA
    Cardiovasc Toxicol 4:97-107. 2004
    ..HIV-1, gp120, or Tat induced Erk 1/2 phosphorylation, activation of caspase-3, and apoptosis of NRVMs and CAECs; all of these were inhibited by a ..
  19. ncbi Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit
    Christine Dozier
    Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération, UMR 5088 CNRS, Institut Fédératif de Recherche 109, Universite Paul Sabatier, Bât 4R3 B1, 118 route de Narbonne, 31062 Toulouse, France
    Biol Cell 96:509-17. 2004
    ..Finally, we demonstrated that overexpressing B'gamma3 in HEK293 suppressed the phosphorylation of Chk2 induced by a genotoxic treatment, suggesting that PP2A may counteract the action of the checkpoint kinase in living cells...
  20. ncbi Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations
    K J Schmitz
    Institute of Pathology and Neuropathology, University Hospital of Essen, Hufelandstr 55, 45122 Essen, Germany
    Virchows Arch 450:151-9. 2007
    ..We propose immunohistochemical determination of pERK1/2 status as a promising candidate for the identification of high-risk patients who would benefit from new anticancer drugs targeting the ERK pathway.
  21. pmc Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds
    L M Luttrell
    The Geriatrics Research, Education and Clinical Center, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Proc Natl Acad Sci U S A 98:2449-54. 2001
    ..examined the role of beta-arrestins in the activation and targeting of extracellular signal-regulated kinase 2 (ERK2) following stimulation of angiotensin II type 1a receptors (AT1aR)...
  22. pmc Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
    Chun Hau Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    EMBO J 24:294-304. 2005
    ..Here, we identify the extracellular signal-regulated kinase (ERK) as a DAPK-interacting protein...
  23. pmc Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation
    Pradeep K Pandey
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School, UMDNJ, Piscataway, NJ 08854, USA
    Mol Cell Biol 25:10695-710. 2005
    ..We show here that human TRAP220/Med1 is a specific substrate for extracellular signal-regulated kinase (ERK) of the mitogen-activated protein kinase (MAPK) family...
  24. ncbi HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier
    Kentaro Hayashi
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Cereb Blood Flow Metab 26:1052-65. 2006
    ..These results indicate that Tat exposure can lead to alterations of the BBB functions and decrease HAART efficacy in the CNS through overexpression of drug efflux transporters...
  25. pmc B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK
    Claire Letourneux
    Department of Hematology, Institut Cochin, INSERM U567, Paris, France
    EMBO J 25:727-38. 2006
    The protein phosphatase 2A (PP2A) acts on several kinases in the extracellular signal-regulated kinase (ERK) signaling pathway but whether a specific holoenzyme dephosphorylates ERK and whether this activity is controlled during ..
  26. pmc Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA
    A G Bukrinskaya
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5120, USA
    Proc Natl Acad Sci U S A 93:367-71. 1996
    ..These results reveal a novel level of regulation of primate lentivirus infectivity...
  27. pmc Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase
    J M Jacque
    University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, MA 01605, USA
    EMBO J 17:2607-18. 1998
    ..In this study, we identify the virion-associated kinase as mitogen-activated protein kinase (ERK/MAPK)...
  28. pmc Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
    ..Our results suggest that this enzyme may have a critical role in regulating the activity of MAPK signalling during early development and organogenesis...
  29. ncbi Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases
    S Dowd
    ICRF Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK
    J Cell Sci 111:3389-99. 1998
    ..In common with Pyst1, Pyst2 shows substrate selectivity for the classical p42 (ERK2) isoform of MAP kinase both in vitro and in vivo, displaying much reduced activity towards stress activated MAP ..
  30. pmc PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
    R Pulido
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
    EMBO J 17:7337-50. 1998
    ..Co-expression of ERK2 with catalytically active PTP-SL in COS-7 cells impaired the EGF-induced activation of ERK2, whereas a PTP-SL ..
  31. ncbi Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide
    Amit Verma
    Robert H Lurie Comprehensive Cancer Center and Section of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:44988-95. 2002
    ..that arsenic trioxide induces activation of the small G-protein Rac1 and the alpha and beta isoforms of the p38 mitogen-activated protein (MAP) kinase in several leukemia cell lines...
  32. ncbi p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia
    Charles S Powell
    Research Service, VAMC 151 1201 NW 16 th St, Miami, FL 33125 1693, USA
    Am J Physiol Lung Cell Mol Physiol 286:L826-33. 2004
    ..Stress-related signaling pathways in epithelial cells are modulated by hypoxia and confer protection from reoxygenation, since hypoxia and chemical inhibition of p38mapk and MEK1/2 similarly increase cytolysis resulting from O2-...
  33. ncbi Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens
    Jin Ran Chen
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:4632-8. 2005
    ..of leptomycin B-induced inhibition of ERK export from the nucleus or overexpression of a green fluorescent protein-ERK2 mutant that resides permanently in the nucleus, converted the anti-apoptotic effect of 17beta-estradiol to a pro-..
  34. ncbi ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1
    Céline Tárrega
    Centro de Investigacion Principe Felipe, Valencia, Spain
    J Biol Chem 280:37885-94. 2005
    The two regulatory residues that control the enzymatic activity of the mitogen-activated protein (MAP) kinase ERK2 are phosphorylated by the unique MAP kinase kinases MEK1/2 and dephosphorylated by several tyrosine-specific and dual ..
  35. pmc Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase
    R H Chen
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:10952-6. 1993
    ..This study suggests a role for nuclear RSK and MAP kinase in modulating newly synthesized c-Fos phosphorylation and downstream signaling...
  36. pmc A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission
    A J Bardwell
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697, USA
    J Biol Chem 276:10374-86. 2001
    ..sequences in human MEK1 and MEK2 are necessary and sufficient for the direct binding of the MAPKs ERK1 and ERK2. Mutations in MEK1, MEK2, or Ste7 that altered conserved residues in the docking site diminished binding of the ..
  37. ncbi Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation
    Haikun Shi
    Department of Biological Chemistry, The Weizmann Institute of Science, P O Box 26, Rehovot 76100, Israel
    J Biol Chem 277:13539-47. 2002
    ..demonstrated that the protein kinase acting on betaThr-613 and gammaThr-623 is the extracellular regulated kinase (ERK)...
  38. ncbi Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1
    Fred L Robinson
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 277:14844-52. 2002
    Extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) are essential components of pathways through which signals received at membrane receptors are converted into specific changes in protein function and gene expression...
  39. ncbi Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription
    Julie Milanini-Mongiat
    Institute of Signalling, Developmental Biology and Cancer Research, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
    J Biol Chem 277:20631-9. 2002
    ..These results highlight Sp1 as a key molecular link between elevated activation of the Ras >> p42/p44MAPK signaling pathway and increased VEGF expression, two major steps deregulated in tumor cells...
  40. pmc Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways
    Angelique Whitehurst
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cell Biol 24:10145-50. 2004
    ..One such module is the Raf-MEK-extracellular signal-regulated kinase (ERK) kinase cascade...
  41. ncbi Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo
    Christopher A Dimitri
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Biol 15:1319-24. 2005
    ..We have examined the in vivo activity of ERK2 mutants with impaired ability to signal via either docking site...
  42. ncbi Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation
    Yong Ping Bai
    Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China
    Biochem Biophys Res Commun 360:20-6. 2007
    ..investigated the effects of Hcy on NF-kappaB-mediated sICAM-1, TNF-alpha production and the possible involvement of ERK(1/2)/p38MAPK pathway. The effects of rosiglitazone intervention were also examined...
  43. doi Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim
    Clare Sheridan
    Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 283:22128-35. 2008
    ..point mutation, V600E, which results in greatly elevated B-Raf kinase activity and constitutive activation of MAPK/ERK downstream...
  44. pmc Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cancer Res 68:5113-21. 2008
    ..These results implicate an important interaction between BRCA1 and ERK1/2 in the regulation of cellular response after IR-induced DNA damage in MCF-7 cells...
  45. doi Identification and characterization of a general nuclear translocation signal in signaling proteins
    Dana Chuderland
    Department of Biological Regulation, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Mol Cell 31:850-61. 2008
    ..identified a 3 amino acid domain (SPS) that is phosphorylated upon stimulation to induce nuclear translocation of ERK2. A 19 amino acid stretch containing this phosphorylated domain inserts nondiffusible proteins to the nucleus ..
  46. pmc Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
    A Greenway
    AIDS Cellular Biology Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia
    J Virol 70:6701-8. 1996
    ....
  47. ncbi Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
    M Saxena
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 274:11693-700. 1999
    ..The specificity of HePTP correlated with its physical association through its noncatalytic N terminus with Erk and another MAP kinase, p38, but not Jnk or other proteins...
  48. ncbi Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Biochem Biophys Res Commun 263:825-31. 1999
    b>p38 MAPK is a Ser/Thr protein kinase activated by various inflammatory cytokines and a variety of stress stimuli. It is involved in many physiological processes, including the production of inflammatory cytokines...
  49. ncbi Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway
    B G Rowan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:4475-83. 2000
    ..395 and threonine 1179) contained a perfect consensus sequence for the mitogen-activated protein kinase family (Erk-1 and Erk-2)...
  50. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..factor NF-kappaB and in the induction of phosphorylation of the mitogen-activated protein kinases ERK1 and ERK2; activation of these two potential substrates of protein kinase C is required for the production of IL-10...
  51. pmc Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
    T Tanoue
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    EMBO J 20:466-79. 2001
    ..Here we have identified a novel site on p38 and ERK2 MAPKs that regulates the docking specificity towards MAPKAPKs...
  52. ncbi Direct integrin alphavbeta6-ERK binding: implications for tumour growth
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, The Royal Women s Hospital, Melbourne and University of Melbourne, Melbourne, Australia
    Oncogene 21:1370-80. 2002
    ..Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells...
  53. ncbi Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK
    Hiroshi Nishihara
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 279:26176-83. 2004
    ..pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A...
  54. pmc Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5
    Margret Mandl
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell Biol 25:1830-45. 2005
    ..which determine the nuclear accumulation and inactivation of the extracellular signal-regulated kinase 1 (ERK1) or ERK2 mitogen-activated protein (MAP) kinases are poorly understood...
  55. pmc The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages
    Brian Tomkowicz
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 108:1145-50. 2006
    ..activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2...
  56. pmc Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling
    Johanna Prast
    Department of Obstetrics and Fetal Maternal Medicine, Reproductive Biology Unit, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Endocrinology 149:979-87. 2008
    ..Addition of the hormone activated ERK-1/2 and AKT in SGHPL-5 cells and pure, extravillous trophoblasts...
  57. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ..Specific inhibition of p38alpha MAP kinase or preventing the activation of ERK1/ERK2 partially reduced the production of these substances, while the combined blockade of both pathways almost abolished ..
  58. pmc HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study
    Ling Bai
    Key Laboratory of Ophthalmology, Ministry of Education Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, PR China
    BMC Infect Dis 8:77. 2008
    ..This study is to determine the effects of HIV-1 Tat proteins on the barrier function and tight-junction protein expression of retinal pigment epithelial cell (RPE)...
  59. pmc HIV-1 activates macrophages independent of Toll-like receptors
    Joseph N Brown
    Division of Rheumatology, Immunology and Infectious Diseases, Department of Pathology, Immunology, and Laboratory Medicine, and Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    PLoS ONE 3:e3664. 2008
    ..Multiple genetic networks involved in regulating signal transduction cascades and immune responses in macrophages are coordinately modulated by HIV-1 infection...
  60. doi Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
    Fengxiang Wei
    Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Cell Signal 22:1783-9. 2010
    ..However, much less has been done to directly examine the contributions of ERK1 and ERK2 kinases to DDR. Etoposide induces G2/M arrest in a variety of cell lines, including MCF7 cells...
  61. pmc Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling cascade
    Di Zhang
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 286:44913-20. 2011
    ..Adiponectin activates AMP-activated protein kinase and p38 mitogen-activated protein kinase (p38MAPK) signaling pathways in adult hNSCs...
  62. pmc X4 Human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4
    Feng Hong
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e33659. 2012
    ..We therefore examined the in vitro impact of X4 gp120 on HSC activation, collagen I expression, and underlying signaling pathways and examined the in vivo expression of gp120 in HIV/HCV coinfected livers...
  63. pmc GLIPR-2 overexpression in HK-2 cells promotes cell EMT and migration through ERK1/2 activation
    Shaoguang Huang
    Department of Clinical Laboratory, Xin Qiao Hospital, Third Military Medical University, Chong Qing, PR China
    PLoS ONE 8:e58574. 2013
    ..GLIPR-2 may be responsible for the development of renal fibrosis by increasing the accumulation of interstitial fibroblasts...
  64. ncbi ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
    T G Boulton
    Department of Pharmacology, University of Texas Southwestern Graduate School of Biomedical Sciences, Dallas 75235 9041
    Cell 65:663-75. 1991
    ..We now describe cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, and provide evidence suggesting that there are additional ERK family members...
  65. pmc Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1
    D R Alessi
    Department of Biochemistry, University of Dundee, Scotland
    EMBO J 13:1610-9. 1994
    ....
  66. ncbi The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
    Y Chu
    Labortory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:6497-501. 1996
    ..A hyperactive allele of ERK2 (D319N), analogous to the Drosophila sevenmaker gain-of-function mutation, has significantly reduced sensitivity to ..
  67. ncbi MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP
    R Janknecht
    Institute for Molecular Biology, Hannover Medical School, Germany
    Biochem Biophys Res Commun 228:831-7. 1996
    ..Thereby MAP kinase stimulation can pleiotropically affect activation of genes regulated by different transcription factors interacting with the same coactivator CBP...
  68. ncbi Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase
    M Oh-hora
    Biomedical Research Center, Osaka University Medical School, Japan
    J Immunol 163:1282-8. 1999
    ..LC-PTP dephosphorylated ERK2 in vitro...
  69. pmc A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
    C Blanco-Aparicio
    Instituto de Investigaciones Citologicas, 46010 Valencia, Spain
    J Cell Biol 147:1129-36. 1999
    ..PKA activators, or overexpression of the Calpha catalytic subunit of PKA, inhibited the cytoplasmic retention of ERK2 and p38alpha by wild-type PTP-SL, but not by a PTP-SL S231A mutant...
  70. ncbi Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
    J M Brondello
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, Nice 06189, France
    Science 286:2514-7. 1999
    ..These results illustrate the importance of regulated protein degradation in the control of mitogenic signaling...
  71. ncbi Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1
    D N Slack
    Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 276:16491-500. 2001
    ..Both binding and catalytic activation of MKP-1 are abrogated by mutation of a conserved docking site in ERK2, p38alpha, and JNK1 MAP kinases...
  72. ncbi Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast
    M Tresini
    The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Exp Cell Res 269:287-300. 2001
    ..phosphorylation of p62(TCF)/Elk-1, which is catalyzed by the members of the extracellular-regulated kinase (ERK) family was strikingly diminished and correlated with a decrease in the abundance of activated ERK proteins...
  73. ncbi PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase
    E Formstecher
    INSERM U114, College de France, Paris
    Dev Cell 1:239-50. 2001
    The ERK 1/2 MAP kinase pathway controls cell growth and survival and modulates integrin function...
  74. pmc Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
    Weiping Wang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 91037, USA
    Mol Cell Biol 22:3389-403. 2002
    ..In this study, we have found that the stress-activated MAPK, p38, is also activated during the onset of ras-induced senescence in primary human fibroblasts...
  75. ncbi Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5
    Prem P Dwivedi
    Department of Molecular Biosciences Biochemistry, University of Adelaide, Adelaide, Australia 5005
    J Biol Chem 277:29643-53. 2002
    ..Evidence was obtained for distinct roles of ERK1/ERK2 and ERK5 in the 1,25D-inductive actions...
  76. ncbi The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases
    Bo Zhou
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:31818-25. 2002
    The extracellular signal-regulated protein kinase 2 (ERK2) is the founding member of a family of mitogen-activated protein kinases (MAPKs) that are central components of signal transduction pathways for cell proliferation, stress ..
  77. ncbi gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes
    Sandrina Kinet
    Institut de Genetique Moleculaire de Montpellier, Centre National de Recherche Scientifique CNRS UMR 5535 IFR 22, Montpellier, France
    Blood 100:2546-53. 2002
    ..These studies reveal a mechanism via which gp120 may differentially modulate the fate of activated and quiescent T cells in vivo...
  78. pmc IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation
    Josefina Garcia
    Department of Hematology, Institut Cochin, INSERM U567, CNRS UMR 8104, Universite Rene Descartes, 27 rue du Fg St Jacques, 75014 Paris, France
    EMBO J 21:5151-63. 2002
    ..IEX-1 was isolated by phosphorylation screening with active ERK2 and found subsequently phosphorylated in vivo upon ERK activation...
  79. ncbi ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a
    Wu Wen-Sheng
    Department of Medical Technology, Tzu Chi University, Hualien, Taiwan
    Oncogene 22:955-63. 2003
    ..Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11...
  80. ncbi Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs
    Scott T Eblen
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:14926-35. 2003
    ..As a first step in achieving this goal, we engineered a mutant ERK2 in which a bulky amino acid residue in the ATP binding site (glutamine 103) is changed to glycine, allowing this ..
  81. pmc Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor
    Paula Monje
    Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 23:7030-43. 2003
    ..regulates AP-1 by stimulating the expression and function of c-Fos through extracellular signal-regulated kinase (ERK)...
  82. pmc The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression
    Amy L Silvers
    Department of Radiation Oncology, Arizona Cancer Center, The University of Arizona, Tucson, AZ, USA
    Neoplasia 5:319-29. 2003
    ..UVA-induced phosphorylation of p38 and c-Jun N-terminal kinase (JNK) proteins was detected immediately after irradiation and disappeared after ..
  83. ncbi Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
    Tilman Brummer
    Department of Molecular Immunology, Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg 79108, Germany
    Oncogene 22:8823-34. 2003
    ..By site-directed mutagenesis studies, we demonstrate that the shift is due to an ERK2-mediated feedback phosphorylation of serine/threonine residues within an evolutionary conserved SPKTP motif at the ..
  84. ncbi IQGAP1 binds ERK2 and modulates its activity
    Monideepa Roy
    Department of Pathology, Brigham, and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:17329-37. 2004
    ..In vitro analysis with purified proteins demonstrated a direct interaction between ERK2 and IQGAP1...
  85. ncbi Regulation of Raf-1 by direct feedback phosphorylation
    Michele K Dougherty
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Mol Cell 17:215-24. 2005
    ..in the Ras pathway to transmit mitogenic, differentiative, and oncogenic signals to the downstream kinases MEK and ERK. Because of its integral role in cell signaling, Raf-1 activity must be precisely controlled...
  86. ncbi Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
    Deanna G Adams
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 280:42644-54. 2005
    ..Pharmacological inhibitor studies as well as reporter assays for ERK-dependent activation of the transcription factor Elk1 revealed that the PP2A holoenzymes ABalphaC and ABdeltaC act ..
  87. pmc In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the releas
    Giorgio Mangino
    Department of Biology University Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    J Virol 81:2777-91. 2007
    ..and transient phosphorylation of the alpha and beta subunits of the IkappaB kinase complex and of JNK, ERK1/2, and p38 mitogen-activated protein kinase family members...
  88. pmc Mxi2 promotes stimulus-independent ERK nuclear translocation
    Berta Casar
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas CSIC, Departamento de Biologia Molecular, Unidad de Biomedicina CSIC Universidad de Cantabria, Santander, Spain
    EMBO J 26:635-46. 2007
    ..This process requires the direct interaction of both proteins and a high-affinity binding of Mxi2 to ERK-binding sites in nucleoporins, In this respect, Mxi2 acts antagonistically to PEA15, displacing it from ERK1/2 ..
  89. ncbi Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis
    Yasunari Mizumoto
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 98:652-8. 2007
    The extracellular-regulated kinase (ERK) signaling pathway plays important roles in regulating the malignant potential of cancer cells in vitro...
  90. pmc Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation
    Devang N Patel
    Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229 4404, USA
    J Biol Chem 282:27229-38. 2007
    ..Overexpression of wild type p50, p65, and C/EBPbeta stimulated CRP transcription. IL-17 stimulated p38 MAPK and ERK1/2 activation, and SB203580 and PD98059 blunted IL-17-mediated NF-kappaB and C/EBP activation and CRP ..
  91. ncbi Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells
    Eing Mei Tsai
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung, Taiwan, Republic of China
    Fertil Steril 89:1522-9. 2008
    ..To elucidate the role of RU486 in regulating the function of granulosa luteal cells and its possible involvement in ovarian dysfunction...
  92. pmc Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases
    Christopher J Caunt
    Laboratories for Integrated Neuroscience and Endocrinology, Department of Clinical Sciences at South Bristol, University of Bristol, Whitson Street, Bristol, U K
    J Biol Chem 283:6241-52. 2008
    ..microscopy in combination with a system where endogenous ERKs are removed and replaced with wild-type or mutated ERK2-green fluorescent protein (GFP), we show that ERK2 activation responses to epidermal growth factor (EGF) and ..
  93. doi Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases
    Stephen Paul Armstrong
    Department of Clinical Sciences at South Bristol, University of Bristol, Bristol BS1 3NY, UK
    Mol Endocrinol 23:510-9. 2009
    ..roles using short inhibitory RNA to knock down endogenous ERK, adenoviruses to express GnRH receptors and add-back ERK2-GFP, and automated microscopy to monitor ERK location and activation...
  94. pmc Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells
    Elizabeth R Smith
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 5:e9295. 2010
    The MAPK/ERK1/2 serine kinases are primary mediators of the Ras mitogenic signaling pathway. Phosphorylation by MEK activates MAPK/ERK in the cytoplasm, and phospho-ERK is thought to enter the nucleus readily to modulate transcription.
  95. doi Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB
    Chuen Mao Yang
    Department of Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 224:516-26. 2010
    ..IL-1beta-induced ICAM-1 expression, extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation, and nuclear factor-kappaB (NF-kappaB) p65 ..
  96. doi Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia
    Olga Bermudez
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Universite de Nice Sophia Antipolis, Nice, France
    J Cell Physiol 226:276-84. 2011
    ..Previous data have shown that the MEK/ERK axis exerts a retro-control on its own signaling through transcriptional and post-translational regulation of DUSP6...
  97. doi Human immunodeficiency virus type 1 Tat modulates proliferation and differentiation of human neural precursor cells: implication in NeuroAIDS
    Mamata Mishra
    Molecular and Cellular Neuroscience, National Brain Research Center, Manesar, Haryana, India
    J Neurovirol 16:355-67. 2010
    ..Validation with autopsy brain samples is necessary to further substantiate these important observations...
  98. ncbi Clarifying the role of G protein signaling in HIV infection: new approaches to an old question
    Jennifer A Juno
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    AIDS Rev 12:164-76. 2010
    ....
  99. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
    ..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox...
  100. doi Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    Xiao Feng Chen
    Department of Thoracic Surgury, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Mol Biol Rep 39:3549-56. 2012
    ....
  101. pmc Processive phosphorylation of ERK MAP kinase in mammalian cells
    Kazuhiro Aoki
    Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:12675-80. 2011
    ..dissect these input-output behaviors, we quantitatively measured the kinetic parameters involved in the MEK (MAPK/ERK kinase)-ERK MAP kinase signaling module in HeLa cells...

Research Grants110 found, 100 shown here

  1. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
    ..A major hypothesis is that extracellular signal-regulated kinase (ERK) and p38 MAPK signaling pathways inversely regulate the duration and amplitude of NF-:B activation induced by cytokines, ..
  2. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John M Kyriakis; Fiscal Year: 2010
    ..mixed-lineage kinases (MLKs)-2 and -3), is required for activation of the Jun-N-terminal kinase (JNK) and p38 MAPK groups by a clinically relevant subset of pathogen-associated molecular patterns (PAMPs-molecular moieties, ..
  3. Jin Kyung Kim; Fiscal Year: 2016
    ..We hypothesize that estrogen signals to several important regulators of cell fate in ischemic stress - cardiac p38 mitogen-activated protein kinases (p38 MAPKs) and p53, a well-known mediator of apoptosis - to protect the ..
  4. Emilio B Gonzalez; Fiscal Year: 2014
    ..family named receptor associated protein (RAP) affect aPL-mediated upregulation of TF, ICAM-1, cytokines and p38 mitogen activated protein kinase (p38 MAPK) phosphorylation in EC and activation of monocytes and platelets...
  5. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    ..signaling using PH-GFP constructs, examine Rac signaling using a GFP- probe that binds active Rac, and investigate p38 MAPK signaling using specific antibodies and inhibitors. C...
  6. Estrogen receptor, p38 MAPKs and topo IIa in breast cancer
    Guan Chen; Fiscal Year: 2013
    ..b>p38 MAPKs consist of 1, 2, 3, and 4 proteins that are major kinase cascades to determine cellular response to upstream ..
  7. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..cultures, AMP peptide increased accumulation of TJ proteins (occludin, ZO-1), and stimulated the phosphorylation of p38 MAP kinase and heat shock protein 25 which could stabilize actin filaments...
  8. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
    ..Nonetheless, CO can activate p38 MAP kinase signaling resulting in apoptosis...
  9. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
    ..that stress-induced dynorphin release activates kappa opioid receptors (KOR) that stimulate phosphorylation of p38 MAPK expressed by both astroglial cells and GABAergic neurons in brain...
  10. The Role of Xanthine Oxidoreductase in Ventilator-Associated Lung Injury
    Paul M Hassoun; Fiscal Year: 2013
    ..Furthermore, we have recently linked VALI-associated capillary vascular leakage to p38 MAPK/XOR signaling...
  11. Exercise Induced Biochemical and Anatomical Adaptations
    John O Holloszy; Fiscal Year: 2013
    ..Relative to this goal our aims are to test the hypotheses that activation of p38 MAPK is the next step in the pathway leading from CAMK and AMPK to increased mitochondrial biogenesis and GLUT ..
  12. Small heat shock proteins in smooth muscle plasticity
    William T Gerthoffer; Fiscal Year: 2013
    ..proposing a substantial shift in focus of the project to test the novel idea that phosphorylation of HSP27 via the p38 MAPK/MK2 pathway inhibits the function of the miRNA silencing machinery...
  13. Mercedes Rincon; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The p38 MAP kinase (MAPK) pathway is activated in response to stress stimuli (e.g...
  14. TAMMY ANGALINE BUTTERICK; Fiscal Year: 2016
    ..OxA has been shown to activate extracellular signal-regulated kinases 1/2 (ERK1/2) and p38 mitogen activated phosphate kinase (MAPK) in various cell models...
  15. MECHANISM OF CANALICULAR BILE FORMATION AND CHOLESTASIS
    MOHAMMED SAWKAT ANWER; Fiscal Year: 2010
    ..the role of aPKCz, Rab4 and phosphorylation in Ntcp translocation and started defining the role of nPKCd, nPKCe and p38 MAPK in Mrp2 translocation...
  16. Signaling and microRNA function in neurons
    David L Turner; Fiscal Year: 2012
    ..Phosphorylation of the Ago-2 protein by the p38 MAP kinase/MAPKAP kinase 2 (MAPKAP-K2) pathway alters its subcellular localization, and p38 kinase/ MAPKAP-K2 ..
  17. Mechanism of Anthrax Lethal Factor Toxicity
    Usamah S Kayyali; Fiscal Year: 2012
    ..We have shown that p38 MAP kinase activation leading to HSP27 phosphorylation by the kinase MK2 augments the endothelial permeability ..
  18. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    RANDY DEAN BLAKELY; Fiscal Year: 2010
    ..phosphorylation, and 3) a lack of responsiveness to multiple SERT posttranslational regulatory pathways including p38 MAPK pathways activated by inflammatory cytokines...
  19. MAP Kinase Signaling in Apoptosis-Induced Ventilator-Associated Lung Injury
    Mahendra Damarla; Fiscal Year: 2013
    ..Additionally, the p38 mitogen activated protein (MAP) kinase, a known mediator of endothelial cell apoptosis is activated in response to ..
  20. Regulation of Skeletal Muscle Regeneration
    Yi Ping Li; Fiscal Year: 2012
    ..The activation of p38 MAPK plays a critical role in chromatin remodeling and in the activation of key myogenic transcription factors and, ..
  21. SANDRA ANN REMPEL; Fiscal Year: 2015
    ..Furthermore, we found that SPARC induces migration and invasion via the activation of p38 MAPK-MAPKAPK2-HSP27 signaling pathway...
  22. Nicholas P Poolos; Fiscal Year: 2016
    ..A novel modulator of HCN channel gating, p38 mitogen- activated kinase (p38 MAPK), was characterized as well, with inhibition of p38 MAPK causing downregulation ..
  23. MOHAMMED SAWKAT ANWER; Fiscal Year: 2014
    ..the role of aPKC , Rab4 and phosphorylation in Ntcp translocation and started defining the role of nPKC , nPKC and p38 MAPK in Mrp2 translocation...
  24. Wendell G Yarbrough; Fiscal Year: 2016
    ..We have recently found and confirmed that LZAP binds the stress activated protein kinase, p38 MAPK (hereafter p38), and the wild-type p53 induced phosphatase, Wip1...
  25. Michael B Yaffe; Fiscal Year: 2016
    ..the ATR-Chk1 and ATM-Chk2 pathways that are dedicated to responding solely to signals from DNA damage per se, the p38 MAPK-MK2 pathway is a much more global stress-response pathway that can also be activated by other types of ..
  26. The role of microglial-and neuron-specific MyD88 signaling in tauopathies
    Kiran Bhaskar; Fiscal Year: 2013
    ..reactive microglia induces MAPT phosphorylation in primary neurons via activating neuronal IL1-receptor (IL1-R) and p38 mitogen activated protein kinase (p38 MAPK) pathway...
  27. Adherence Activated Monocyte Genes
    Gary Brewer; Fiscal Year: 2009
    ..ifmonocytes are cultured in the presence of either a tyrosine kinase inhibitor, or a MEK kinase inhibitor, or a p38 MAP kinase inhibitor...
  28. Anthrax Lethal Toxin-Induced Heart Failure: Role of PP2A and MAP Kinases
    David E Dostal; Fiscal Year: 2013
    ..changes in left ventricular tissue suggests that cleavage of MEKs by anthrax LT causes an imbalance in ERK, JNK and p38 MAPK activity that results in PP2A activation and reduced contractile function...
  29. Epilepsy and dendritic excitability
    NICHOLAS POOLOS; Fiscal Year: 2009
    ..A novel modulator of HCN channel gating, p38 mitogen- activated kinase (p38 MAPK), was characterized as well, with inhibition of p38 MAPK causing downregulation ..
  30. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2010
    ..a stable endocannabinoid analog) activate phospholipase C, increase intracellular calcium and stimulate p38 MAP kinase phosphorylation in GPR55-expressing HEK293 cells...
  31. Peiqing Sun; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The p38 MAPK pathway was initially identified as a mediator of inflammatory and stress responses...
  32. Peiqing Sun; Fiscal Year: 2016
    ..Studies from our lab indicate that the p38 MAPK and its downstream substrate kinase PRAK play a key role in oncogenic ras-induced senescence and tumor ..
  33. Yusuf Awni Hannun; Fiscal Year: 2015
    ..to the hypothesis that the novel salvage pathway involving GBA1/ceramide/CAPP functions to regulate the activity of p38 MAPK, which in turn couples the GBA/ceramide pathway to the regulation of cytokine-induced inflammatory responses, ..
  34. NEUROMODULATION OF THE ANTIBODY RESPONSE
    Virginia M Sanders; Fiscal Year: 2012
    ..CSR), through a mechanism that appears to inactivate Hematopoetic protein tyrosine phosphatase (HePTP) and enhance p38 MAPK phosphorylation to mediate an increase in ADAM10, which cleaves membrane CD23 to a soluble form...
  35. ETHANOL AND MAP KINASE CASCADE
    SHIVENDRA SHUKLA; Fiscal Year: 2009
    ..Based on new supporting data, it is hypothesized that "ethanol modulates p38 MAPK activity leading to downstream activation of nuclear mitogen and stress activated kinase-1 (MSK-1) and ..
  36. Hypoxia-induced Endothelial Barrier Dysfunction
    Usamah Kayyali; Fiscal Year: 2009
    ..Preliminary studies have led to the hypothesis that exposure to hypoxia initiates cell signaling through the p38 MAP kinase pathway involving MK2 and HSP27 activation that leads to actin cytoskeleton and hic-5 redistribution...
  37. NGF-Dependent Sensitization of Nociceptors by Opiates
    Frank Porreca; Fiscal Year: 2012
    ..and an increase in expression of NGF in peripheral tissues;(b) increase NGF-dependent phosphorylation of p38 MAPK (pp38 MAPK) in TrkA-positive cells, (c) increase NGF-dependent and pp38 MAPK-dependent trafficking of the ..
  38. REGULATION OF SEROTONIN TRANSPORTERS
    Randy D Blakely; Fiscal Year: 2010
    ..In Specific Aim II, we examine the role of p38 mitogen associated protein kinase (MAPK) in modulating SERT intrinsic activities...
  39. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..for IkB[unreadable], nuclear p50, and phosphorylation of mitogen activated protein kinases (MAPKs - ERK, p38, JNK);at 3h post reperfusion for RT-PCR to quantify lung tissue mRNA concentrations of TNF-[unreadable], MIP-1[..
  40. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..protein kinases (MAPK), including ERK 1/2 and two stress-activated protein kinases (SAPK), JNK and p38. These MAPK are increased in LIRI, and in situ models demonstrate protection with p38 and JNK inhibition...
  41. Renate B Pilz; Fiscal Year: 2014
    ..protein kinase (PKG) pathway, and that PKG activation is necessary for shear-induced Src and Erk activation...
  42. Regulation of Ovarian Cancer Multidrug Resistance by MAP Kinases
    Scott T Eblen; Fiscal Year: 2013
    ..chemotherapeutic agents and cellular stimuli induce activation the mitogen-activated protein kinases (MAP kinases) ERK, JNK and p38, all of which are associated with modulating cell survival responses through phosphorylation of their ..
  43. Farrukh Afaq; Fiscal Year: 2014
    ..In malignant melanoma the BRAF-MEK-ERK and PI3K-AKT-NFkB signaling pathways are constitutively activated and regulated by RAS signals...
  44. Interactions and Dual Phosphorylation in MAP Kinase Cascades
    Elizabeth J Goldsmith; Fiscal Year: 2010
    ..MAP2Ks and MAPKs, defined in several labs, were studied crystallographically in the low activity forms of MAPKs ERK2 and p38alpha...
  45. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..We will study the time course of FAK dephosphorylation and activation of downstream signaling pathways ERK, JNK, p38 MAP kinase and NF:B, which are known to activate MMPs...
  46. Tatiana Efimova; Fiscal Year: 2014
    ..The p38 MAPK family members function in a cell type-specific and cell context-specific manner to regulate cell ..
  47. Marcus Kaul; Fiscal Year: 2016
    ..We also observed that RANTES and MIP-1? via CCR5 reduce the activity of the pro-inflammatory and stress-related p38 mitogen activated protein kinase (MAPK) and protect cerebrocortical neurons against neurotoxicity of HIV/gp120 in ..
  48. KATHERINE JULIA KELLY; Fiscal Year: 2014
    ..postulate that both systemic, particularly interleukins (interleukin)-1 and -6, and intrarenal (angiotensin II and p38 mitogen activated protein kinase) mediators regulate ICAM-1 and LOX-1 and therefore inflammation and function in ..
  49. Regulation of Bile Acid Synthesis by Nuclear Receptors in Vivo
    Gregorio Gil; Fiscal Year: 2012
    ..7- and 12-hydroxylases, by a two-step mechanism: first, bile acids suppress HNF-4 through a process mediated by the p38 MAP kinase pathway (a novel observation recently made in the P.I...
  50. Serrine S Lau; Fiscal Year: 2014
    ..Specifically, those mediators are Nrf2, Grp78, and p38 MAPK, each of which is also a key mediator of ischemia preconditioning...
  51. MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURY
    Jeffrey R Bender; Fiscal Year: 2012
    ..of T cell LFA-1-mediated HuR translocation and mRNA stabilization, focusing on the Rac downstream targets p38 MAPK, MAPK-activated protein kinase 2 (MK2) and novel, T cell-specific MK2 targets, using pharmacologic inhibitors, ..
  52. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..reported that PFE exert a potent inhibitory effect on IL-1[unreadable]-induced activation of MAPK sub-groups p38-MAPK and JNK, transcription factor NF-?B and the expression of MMPs by human cartilage explants and chondrocytes in ..
  53. Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinases
    Sheila Collins; Fiscal Year: 2009
    ..we have shown that additional signaling cascades emanate from [unreadable]ARs in adipocytes, and these include the ERK and p38 MAP kinase pathways...
  54. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
    ..by translating neurotrophin-initiated signals into multiple signaling pathways, including PI-3 kinase/Akt and MEK/ERK, to promote survival...
  55. Lei Wei; Fiscal Year: 2015
    ..repression of HDAC4 control chondrocyte differentiation and are regulated by Ca2+/calmodulin kinase IV (CaMKIV), p38 MAP kinase, and microRNA-1 respectively at different zone in the growth plate...
  56. Sven Eric Jordt; Fiscal Year: 2016
    ..TRP channel, through influx of calcium, activate p38 MAP kinase, a major transducer and activator of inflammation and cell death in injured tissue...
  57. Tahir Hussain; Fiscal Year: 2016
    ..Aim 1 will study the role of p38 MAP kinase and transcription factors IRF-1 and C/EBP2 in increasing AT2 receptor expression by high glucose ..
  58. Johnathan D Tune; Fiscal Year: 2016
    ..g. cAMP, PKA, p38 MAPK) and the regulation of myocardial glucose and fatty acid transporters (e.g. GLUT4, FAT/CD36) in lean vs...
  59. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..work from this laboratory has shown that PFE exert a potent inhibitory effect on IL-IB-induced activation of p38-MAPK and JNK, NF-kB and expression of matrix metalloproteinases (MMPs) by human cartilage explants and chondrocytes ..
  60. Kenneth R McLeish; Fiscal Year: 2016
    ..Specific Objective 3 will test the working hypothesis that p38 MAPK phosphorylates multiple proteins that mediate events necessary for priming, including exocytosis and Pin1 ..
  61. INFLAMMATORY RESPONSES IN THE TOXICITY OF RICIN
    Bruce Magun; Fiscal Year: 2009
    ..translation, but also the intense and extended activation of the stress-activated protein kinases such as JNK and p38 MAPK...
  62. Ronglih Liao; Fiscal Year: 2015
    ..and demonstrated that human amyloidogenic LC (AL-LC) provoke a cardiotoxic effects via activation of non-canonical p38 MAPK signaling cascade and subsequently lead to increase cellular oxidant stress, altered calcium homeostasis, ..
  63. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  64. Priyabrata Mukherjee; Fiscal Year: 2016
    ..of HUVECs, downregulates VEGFR2 at the transcriptional and possibly at the translational level and downregulates ERK- 1/2 phosphorylation...
  65. David A Bernlohr; Fiscal Year: 2014
    ..ROS production leads to the oxidation of Thioredoxin 2 (Trx2) and the activation of Trx2-ASK1-JNK/p38 signaling system contributing to insulin resistance...
  66. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..The major objective of the proposed research plan is to understand the molecular mechanism by which the ERK MAP kinase pathway modulates integrin function...
  67. Jeanette Gowen Cook; Fiscal Year: 2016
    ..roles in cell proliferation, we reasoned that a signaling pathway mediated by the stress-activated MAP kinases, p38 and JNK, could have an equally important impact on origin licensing...
  68. Laurie J Ozelius; Fiscal Year: 2016
    ..The molecular counterparts of the behaviors will be assayed via measures of induction of phosphorylation of ERK and DARPP-32, following D1R, D2R, and A2AR receptor agonists and antagonists...
  69. Jun Chen; Fiscal Year: 2014
    ..via inhibiting both the ASK1/JNK-dependent mitochondrial death-signaling pathway in dopaminergic neurons and ASK1/p38-dependent pro-inflammatory reactions of microglia...
  70. Derek W Abbott; Fiscal Year: 2016
    ..MAP3K which inhibits NEMO ubiquitination and shifts innate immune signaling from NF[unreadable]B activity toward p38 activity...
  71. Novel tools for identifying GPCR compounds modulating specific sub-cellular ERK a
    Haifeng Eishingdrelo; Fiscal Year: 2013
    ..We propose four aims for the project. Aim 1. Develop G-protein-dependent ERK2 activation pathway assay...
  72. Matthew P DeLisa; Fiscal Year: 2014
    ..engineered against the nonphosphorylated (inactive) and phosphorylated (active) isoforms of a well-studied target, ERK2, a member of the MAPK family whose members are well known to regulate several physiological and pathological ..
  73. Swathi Arur; Fiscal Year: 2016
    ..Among the crucial components are the RAS-extracellular regulated kinase (ERK) signaling pathway and Dicer and Drosha, essential mediators of small RNA biogenesis...
  74. PAUL ROBERT EVANS; Fiscal Year: 2015
    ..RGS14 is a complex scaffold/effector that integrates G protein and H-Ras/MAPK signaling pathways to suppress ERK signaling...
  75. Signaling Pathways in Neuronal Cells
    Marsha R Rosner; Fiscal Year: 2013
    ..An evolutionarily conserved protein that is expressed from bacteria to man, RKIP inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkB signaling cascades...
  76. Arindam Bhattacharjee; Fiscal Year: 2016
    ..During diabetes, the p38 mitogen-activated protein kinase (p38MAPK) signaling system is activated and when this pathway is inhibited, ..
  77. Ronald B Gartenhaus; Fiscal Year: 2015
    ..DESCRIPTION (provided by applicant): Extensive preclinical data supports the relevance of the MAP kinase RAS/RAF/MEK/ERK signaling pathway in cancer biology and its potential as a therapeutic target in human cancers...
  78. Novel SET Antagonists for the Treatment of Chronic Myelogenous Leukemia
    Dale J Christensen; Fiscal Year: 2013
    ..CML cells and blast phase CML cells;evaluate the activatin of PP2A in these cells;determine the effect of OP449 treatment on phosphorylation of BCR/ABL, ERK, AKT and STAT5;an inhibit growth in an in vivo model of CML.
  79. Alan B Cantor; Fiscal Year: 2016
    ..kinases (SFKs), and synergistic RUNX1:Ets transcription factor interactions involving a region targeted by MEK/ERK-mediated phosphorylation...
  80. Wafik S El-Deiry; Fiscal Year: 2016
    ..Furthermore, we found that TIC10 results in the dual inactivation of Akt and ERK, thereby inhibiting their constitutive phosphorylation of Fox3a and potentiating its translocation to the nucleus ..
  81. Anjali M Rajadhyaksha; Fiscal Year: 2016
    ..Furthermore, we have found that Cav1.2-activated kinase pathways (CaMKII and ERK) regulate cocaine-induced increase in cell surface GluA1, but not GluA2 in the NAc...
  82. Qiang Wang; Fiscal Year: 2016
    ..provided by applicant): The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) is enriched in synaptic structures...
  83. Thomas J Kodadek; Fiscal Year: 2016
    ..the mechanism by which phosphorylation of Ser207 leads to dissociation of LysRS from the MSC scaffold protein p38 and therefore from the MSC...
  84. KOY Y SAETEURN; Fiscal Year: 2015
    ..TGF-b also activates non-Smad pathways including the PI3K-Akt-mTOR and Erk- MAP kinase pathways, key signaling pathways that are induced by receptor tyrosine kinases and are often ..
  85. Mechanisms of Tauopathies and Synucleopathies
    Anita Sidhu; Fiscal Year: 2012
    ..assess the underlying mechanisms of various kinases known to hyperphosphorylate Tau, including protein kinase A, p- ERK and p-GSK-3(3...
  86. Dianqing Wu; Fiscal Year: 2016
    ..In this pathway, LPA acts, through a G[unreadable]12-ARAF-ERK pathway, to transcriptionally upregulate the expression of an ubiquitin E3 ligase RFFL, which polyubiquitinates and ..
  87. Elias Aizenman; Fiscal Year: 2016
    ..a Zn2+-mediated apoptotic-enabling signaling pathway that culminates with the SNARE-dependent insertion of p38/Src dual phosphorylated Kv2.1-encoded K+ channels in the neuronal plasma membrane...
  88. Role of TGF-b-induced Shc-Erk MAPK signaling in epithelial-mesenchymal transition
    Baby Periyanayaki Muthusamy; Fiscal Year: 2013
    ..activate Smads as transcription effectors that regulate gene expression, and several non-Smad pathways such as the Erk MAP kinase and PI3 kinase-Akt-TOR pathways...
  89. Role of ERK1/2 in Neuromuscular Synapses and Myofiber Development in vivo
    Mendell Rimer; Fiscal Year: 2013
    ..Furthermore, our preliminary data show that loss of ERK2 in myofibers leads to defects in NMJ maintenance in young adult mice...
  90. Peter J Hornsby; Fiscal Year: 2014
    ..While stress resistance is complex, there are three key pathways: NF-?B, p38 MAP kinase, and cell thiol metabolism, that have been implicated in the adverse effects of oxidative stress and ..
  91. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    Richard J Traub; Fiscal Year: 2013
    ..in the same dorsal horn neurons, expression in glial cells, differential activation of MAPK pathways (ERK, p38 MAPK, JNK) in visceral nociceptive processing and the effect of activation of MAPK pathways on the response of the ..
  92. Fibrosis-Protease Cross-Talk Regulating Pancreatic Cancer Invasion
    Hidayatullah G Munshi; Fiscal Year: 2013
    ..Our preliminary data also indicate that MT1-MMP increases cyclin D1 expression and enhances p38 MAPK signaling to promote growth in collagen-rich microenvironment...
  93. Anna Aldovini; Fiscal Year: 2014
    ..b>p38 MAPK, which has been reported to be activated in HIV and SIV infection, is key in the pathway of induction of ISG ..
  94. Elucidating the Fas-activated inflammation-signaling complex (FISC)
    Mihail Iordanov; Fiscal Year: 2013
    ..pathways that activate the nuclear factor-kappa B (NF-kB), the stress-activated protein kinases (SAPK) JNK and p38 MAP kinase, and the epidermal growth factor receptor (EGFR)-Ras-ERK MAP kinase cascade...
  95. FRANCESCO B RAMIREZ; Fiscal Year: 2014
    ..TGFB activation (Project 2), matrix-Induced perturbations of aorta homeostasis and repair (Project 3), and improper p38 MAPK activity and unbalanced TGFB and BMP signaling in the vascular and skeletal systems, respectively (Project 4)...
  96. RACHEL HESLER; Fiscal Year: 2015
    ..TGF-? induces p38 MAPK signaling via TRAF6, and our preliminary studies indicate TGF?-p38 MAPK signaling plays an important role in ..
  97. Xiaoyi Zhang; Fiscal Year: 2015
    ..Mitogen-activated protein kinases (MAPK), such as p38, JNK, and ERK, relay information from extracellular signals to the effectors which control these diverse cellular ..
  98. Thomas J Slaga; Fiscal Year: 2016
    ..including new data added to this application, we have found that UA had inhibitory effects on epidermal Akt, NFkB, p38 MAPK and JNK activation induced by TPA treatment. UA also inhibited TPA-induced epidermal hyperproliferation...
  99. Transient Receptor Potential Vanilloid-1 Sensitization in Inflammation
    JARED MICHAEL SPRAGUE; Fiscal Year: 2013
    ..We will begin with compounds that are known to block important signaling molecules such as PKA, PKC, PI3K, and p38 MAPK with the objective of finding key pathways important for TRPV1 sensitization...
  100. Lisa J Wood; Fiscal Year: 2015
    ..of ZAK, a MAP3K activated by the chemotherapeutic agent, that prolongs and intensifies the activation of JNK and p38 MAPK and synergizes with NF-kB to amplify the expression of pro-IL-1b...