ERK1

Summary

Gene Symbol: ERK1
Description: mitogen-activated protein kinase 3
Alias: ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3, MAP kinase isoform p44, MAPK 1, extracellular signal-regulated kinase 1, extracellular signal-related kinase 1, insulin-stimulated MAP2 kinase, microtubule-associated protein 2 kinase
Species: human

Top Publications

  1. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
  2. ncbi Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells
    A Marti
    Diabetes Unit and Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 021291, USA
    J Biol Chem 272:2620-8. 1997
  3. ncbi BRCA1-induced apoptosis involves inactivation of ERK1/2 activities
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 277:33422-30. 2002
  4. pmc Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
  5. ncbi Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
    H Gille
    Max Planck Institut fur Immunbiologie, Spemann Laboratories, Freiburg, Germany
    Nature 358:414-7. 1992
  6. ncbi Phosphorylation of c-jun mediated by MAP kinases
    B J Pulverer
    Ludwig Institute for Cancer Research, London, UK
    Nature 353:670-4. 1991
  7. pmc Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA
    A G Bukrinskaya
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5120, USA
    Proc Natl Acad Sci U S A 93:367-71. 1996
  8. pmc Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase
    J M Jacque
    University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, MA 01605, USA
    EMBO J 17:2607-18. 1998
  9. pmc PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
    R Pulido
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
    EMBO J 17:7337-50. 1998
  10. ncbi Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
    M Saxena
    Laboratory of Signal Transduction, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Nat Cell Biol 1:305-11. 1999

Research Grants

  1. Renate B Pilz; Fiscal Year: 2014
  2. Cannabinoids and Neuroimmune Interactions
    Edgar Alfonso Romero Sandoval; Fiscal Year: 2010
  3. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
  4. Metastatic protein network in BRAFV600E positive human thyroid cancers
    Carmelo Nucera; Fiscal Year: 2013
  5. Winston E Thompson; Fiscal Year: 2014
  6. Potential of a dominant-negative FGF mutant as a therapeutic in cancer
    Yoshikazu Takada; Fiscal Year: 2012
  7. The role of PKD3 in prostate carcinogenesis
    Qiming Jane Wang; Fiscal Year: 2013
  8. Ronald B Gartenhaus; Fiscal Year: 2015
  9. TAMMY ANGALINE BUTTERICK; Fiscal Year: 2016
  10. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009

Detail Information

Publications228 found, 100 shown here

  1. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ..Specific inhibition of p38alpha MAP kinase or preventing the activation of ERK1/ERK2 partially reduced the production of these substances, while the combined blockade of both pathways almost ..
  2. ncbi Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells
    A Marti
    Diabetes Unit and Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 021291, USA
    J Biol Chem 272:2620-8. 1997
    ..ABP-280 participates in TNF-alpha signal transduction to SAPKs, in part through the binding of SEK-1...
  3. ncbi BRCA1-induced apoptosis involves inactivation of ERK1/2 activities
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 277:33422-30. 2002
    ..In this study, we monitored the activities of three members of the MAPK family (ERK1/2, JNK, p38) in MCF-7 breast cancer cells and U2OS osteosarcoma cells after their exposure to a recombinant ..
  4. pmc Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
    ..These properties define the ability of this enzyme to dephosphorylate and inactivate ERK1/2 and p38alpha, but not JNK (c-Jun N-terminal kinase) in vivo...
  5. ncbi Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
    H Gille
    Max Planck Institut fur Immunbiologie, Spemann Laboratories, Freiburg, Germany
    Nature 358:414-7. 1992
    ..Our results link the expression of the human c-fos proto-oncogene to signal transduction pathways known to be activated before its own induction...
  6. ncbi Phosphorylation of c-jun mediated by MAP kinases
    B J Pulverer
    Ludwig Institute for Cancer Research, London, UK
    Nature 353:670-4. 1991
    ..MAP kinase activation of c-jun may underlie the common stimulation of this transcription factor by mitogens, growth factors and oncogenes...
  7. pmc Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA
    A G Bukrinskaya
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5120, USA
    Proc Natl Acad Sci U S A 93:367-71. 1996
    ..These results reveal a novel level of regulation of primate lentivirus infectivity...
  8. pmc Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase
    J M Jacque
    University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, MA 01605, USA
    EMBO J 17:2607-18. 1998
    ..These studies demonstrate regulation of an early step in HIV-1 infection by the host cell MAPK signal transduction pathway...
  9. pmc PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
    R Pulido
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
    EMBO J 17:7337-50. 1998
    Protein kinases and phosphatases regulate the activity of extracellular signal-regulated kinases 1 and 2 (ERK1/2) by controlling the phosphorylation of specific residues...
  10. ncbi Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
    M Saxena
    Laboratory of Signal Transduction, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Nat Cell Biol 1:305-11. 1999
    The haematopoietic protein tyrosine phosphatase (HePTP) is a negative regulator of the MAP kinases Erk1, Erk2 and p38...
  11. ncbi Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1
    D N Slack
    Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 276:16491-500. 2001
    ..assay to demonstrate that MKP-1 is able to interact selectively with the extracellular signal-regulated kinase 1/2 (ERK1/2), p38alpha, and c-Jun NH(2)-terminal kinase (JNK) MAP kinase isoforms...
  12. ncbi The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases
    V Volmat
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 06189 Nice, France
    J Cell Sci 114:3433-43. 2001
    ..Hence, the nucleus is a critical site for mitogenic signal termination by: (1) nuclear sequestration of p42/p44 MAPKs away from MEK, their cytoplasmic activator; and (2) dephosphorylation by specific nuclear phosphatases...
  13. ncbi Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription
    Julie Milanini-Mongiat
    Institute of Signalling, Developmental Biology and Cancer Research, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
    J Biol Chem 277:20631-9. 2002
    ..Here we show that p42/p44 MAPK directly phosphorylates Sp1 on threonines 453 and 739 both in vitro and in vivo...
  14. ncbi The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells
    John K G Crean
    Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    J Biol Chem 277:44187-94. 2002
    ....
  15. ncbi gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes
    Sandrina Kinet
    Institut de Genetique Moleculaire de Montpellier, Centre National de Recherche Scientifique CNRS UMR 5535 IFR 22, Montpellier, France
    Blood 100:2546-53. 2002
    ..These studies reveal a mechanism via which gp120 may differentially modulate the fate of activated and quiescent T cells in vivo...
  16. ncbi p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades
    Guru Dutt Sharma
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Biol Chem 278:21989-97. 2003
    ..factor (KGF), induced rapid and marked activation and prompt nuclear accumulation of phospho-p38 (p-p38) and -ERK1/2 (p-ERK1/2), but not of JNK (p-JNK1/2), in corneal epithelial cells...
  17. ncbi Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK
    Hiroshi Nishihara
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 279:26176-83. 2004
    ..Studies with pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A...
  18. pmc Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    Philippe P Roux
    Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13489-94. 2004
    ..Together, our data unveil a regulatory mechanism by which the Ras/MAPK and PI3K pathways converge on the tumor suppressor tuberin to inhibit its function...
  19. ncbi HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling
    Milan Fiala
    Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA 90095 1760, USA
    Cardiovasc Toxicol 4:97-107. 2004
    ..HIV-1, gp120, or Tat induced Erk 1/2 phosphorylation, activation of caspase-3, and apoptosis of NRVMs and CAECs; all of these were inhibited by a ..
  20. pmc Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways
    Angelique Whitehurst
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cell Biol 24:10145-50. 2004
    ..factors may include regulation of the duration, amplitude, and/or subcellular compartmentalization of active ERK1/2...
  21. ncbi BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncogene 24:3285-96. 2005
    ..in MCF-7 human breast cancer cells resulted in activation of extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) and G2/M cell cycle arrest...
  22. pmc Active ERK1 is dimerized in vivo: bisphosphodimers generate peak kinase activity and monophosphodimers maintain basal ERK1 activity
    Rada Philipova
    Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Cell Sci 118:5767-76. 2005
    b>ERK1 and ERK2 are widely involved in cell signalling. Using a recombinant approach, it has been shown that exogenous ERK2 is capable of dimerization and that preventing dimerization reduces its nuclear accumulation on stimulation...
  23. ncbi HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier
    Kentaro Hayashi
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Cereb Blood Flow Metab 26:1052-65. 2006
    ..These results indicate that Tat exposure can lead to alterations of the BBB functions and decrease HAART efficacy in the CNS through overexpression of drug efflux transporters...
  24. pmc ERK1c regulates Golgi fragmentation during mitosis
    Yoav D Shaul
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 172:885-97. 2006
    Extracellular signal-regulated kinase 1c (ERK1c) is an alternatively spliced form of ERK1 that is regulated differently than other ERK isoforms...
  25. ncbi Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations
    K J Schmitz
    Institute of Pathology and Neuropathology, University Hospital of Essen, Hufelandstr 55, 45122 Essen, Germany
    Virchows Arch 450:151-9. 2007
    ..of cell proliferation and apoptosis in 135 colorectal cancer cases: AKT and extracellular regulated kinases (ERK1/2)...
  26. pmc In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the releas
    Giorgio Mangino
    Department of Biology University Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    J Virol 81:2777-91. 2007
    ..by the rapid and transient phosphorylation of the alpha and beta subunits of the IkappaB kinase complex and of JNK, ERK1/2, and p38 mitogen-activated protein kinase family members...
  27. ncbi Irradiation-induced G2/M checkpoint response requires ERK1/2 activation
    Y Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncogene 26:4689-98. 2007
    ..gamma-irradiation (IR) exposure of MCF-7 cells resulted in extracellular signal regulated protein kinase 1 and 2 (ERK1/2) activation and induction of G2/M arrest...
  28. ncbi ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
    Chiara Gregorj
    Division of Hematology, Department of Cellular Biotechnologies and Hematology, University La Sapienza of Rome, Italy
    Blood 109:5473-6. 2007
    Extracellular signal-regulated kinase-1/2 (ERK1/2) is frequently found constitutively activated (p-ERK1/2) in hematopoietic diseases, suggesting a role in leukemogenesis...
  29. pmc Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation
    Devang N Patel
    Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229 4404, USA
    J Biol Chem 282:27229-38. 2007
    ..Overexpression of wild type p50, p65, and C/EBPbeta stimulated CRP transcription. IL-17 stimulated p38 MAPK and ERK1/2 activation, and SB203580 and PD98059 blunted IL-17-mediated NF-kappaB and C/EBP activation and CRP transcription...
  30. pmc Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling
    Johanna Prast
    Department of Obstetrics and Fetal Maternal Medicine, Reproductive Biology Unit, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Endocrinology 149:979-87. 2008
    ..Because the increase of CG during the first trimester of pregnancy correlates with rising trophoblast motility, the hormone could be a critical regulator of the early invasion process...
  31. pmc Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells
    Gray W Pearson
    Molecular and Cell Biology Laboratory, Salk Institute, La Jolla, CA 92037, USA
    J Cell Biol 179:1555-67. 2007
    ..Inducible activation of ERK1/2 in mature acini elicits cell motility and disrupts epithelial architecture in a manner that is reminiscent of ..
  32. doi The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFR amplification
    Concha Lopez-Gines
    Department of Pathology, University of Valencia, Valencia, Spain
    Neuropathology 28:507-15. 2008
    The ERK1/2 activated protein kinase (MAPK) pathway is a critical signaling system that mediates ligand-stimulated signals for the induction of cell proliferation, differentiation and survival, involved in malignant transformation...
  33. pmc HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study
    Ling Bai
    Key Laboratory of Ophthalmology, Ministry of Education Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, PR China
    BMC Infect Dis 8:77. 2008
    ..This study is to determine the effects of HIV-1 Tat proteins on the barrier function and tight-junction protein expression of retinal pigment epithelial cell (RPE)...
  34. doi Crystal structure of human mono-phosphorylated ERK1 at Tyr204
    Takayoshi Kinoshita
    Graduate School of Science, Osaka Prefecture University, 1 1 Gakuen cho, Naka ku, Sakai, Osaka 599 8531, Japan
    Biochem Biophys Res Commun 377:1123-7. 2008
    ..The isoforms ERK1 and ERK2 have markedly similar amino acid sequences, but exhibit distinctive physiological functions...
  35. doi Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB
    Chuen Mao Yang
    Department of Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 224:516-26. 2010
    ..These results suggest that in human RASFs, activation of ERK, JNK, AP-1, and NF-kappaB are essential for IL-1beta-induced ICAM-1 expression and leukocyte adhesion...
  36. doi Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
    Fengxiang Wei
    Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Cell Signal 22:1783-9. 2010
    ..However, much less has been done to directly examine the contributions of ERK1 and ERK2 kinases to DDR. Etoposide induces G2/M arrest in a variety of cell lines, including MCF7 cells...
  37. ncbi Clarifying the role of G protein signaling in HIV infection: new approaches to an old question
    Jennifer A Juno
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    AIDS Rev 12:164-76. 2010
    ....
  38. doi Involvement of ERK1/2/NF-κB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620
    Donglin Guo
    Department of Clinical Laboratory and Hematology, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People s Republic of China
    Tumour Biol 32:921-30. 2011
    ..This study has investigated whether extracellular signal-regulated kinase 1 and 2 (ERK1/2) and nuclear factor kappaB (NF-κB) signaling pathways are involved in the events...
  39. doi Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    Xiao Feng Chen
    Department of Thoracic Surgury, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Mol Biol Rep 39:3549-56. 2012
    ..In this study, we performed a study to investigate whether PI3K/Akt and MAPK/Erk1/2 signaling pathways involved in EMT in the human lung cancer A549 cells...
  40. pmc The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells
    Seung Keun Hong
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Exp Cell Res 317:2671-82. 2011
    Upregulated ERK1/2 activity is correlated with androgen receptor (AR) downregulation in certain prostate cancer (PCa) that exhibits androgen deprivation-induced neuroendocrine differentiation, but its functional relevance requires ..
  41. doi NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production
    Yi Qun Kuang
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Eur J Immunol 42:299-310. 2012
    ..Altogether, our results suggest a very important role of the scaffold NHERF1 in the regulation of HIV-1 entry and replication...
  42. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
    ....
  43. pmc X4 Human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4
    Feng Hong
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e33659. 2012
    ..We therefore examined the in vitro impact of X4 gp120 on HSC activation, collagen I expression, and underlying signaling pathways and examined the in vivo expression of gp120 in HIV/HCV coinfected livers...
  44. pmc Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling
    Larissa Dyugovskaya
    The Lloyd Rigler Sleep Apnea Research Laboratory, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Transl Med 10:211. 2012
    ..Specifically, the balance between pro-apoptotic Bax and anti-apoptotic Mcl-1 protein expression, and the potential involvement of p38MAPK and ERK1/2 signaling pathways in the control of Mcl-1 expression were investigated.
  45. pmc Human chorionic gonadotropin β induces migration and invasion via activating ERK1/2 and MMP-2 in human prostate cancer DU145 cells
    Zongwen Li
    Department of Epidemiology and Health Statistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China
    PLoS ONE 8:e54592. 2013
    ..More, hCGβ standards promoted MAPK (ERK1/2) phosphorylation and increased MMP-2 expression and activity in both dose- and time-dependent manners in hCGβ ..
  46. pmc Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function
    Daniel M Aebersold
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 24:10000-15. 2004
    ..We have previously identified an alternatively spliced 46-kDa form of ERK1 that is expressed in rats and mice and named ERK1b...
  47. ncbi Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5
    Prem P Dwivedi
    Department of Molecular Biosciences Biochemistry, University of Adelaide, Adelaide, Australia 5005
    J Biol Chem 277:29643-53. 2002
    ..Evidence was obtained for distinct roles of ERK1/ERK2 and ERK5 in the 1,25D-inductive actions...
  48. ncbi Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling
    Mohamad Z Mehdi
    Laboratory of Cell Signaling, Research Centre, Centre hospitalier de l Université de Montréal Technopôle Angus, Universite de Montreal, Montreal Quebec Canada
    Cell Biochem Biophys 47:1-10. 2007
    ..The upstream elements responsible for H2O2-induced ERK1/2 and PKB activation remain poorly characterized, but a potential role of receptor and nonreceptor protein tyrosine ..
  49. ncbi Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein
    X Yang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 273:29879-87. 1998
    ..These results suggest that MAPK plays a direct role in regulating HIV-1 replication and infectivity by phosphorylating Vif and identify a novel mechanism for activation of HIV-1 replication by mitogens and other extracellular stimuli...
  50. ncbi Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast
    M Tresini
    The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Exp Cell Res 269:287-300. 2001
    ..These impairments, together with the impaired DNA binding activity of SRF, could potentially account for the lack of c-fos expression in senescent cells and for multiple other molecular changes dependent upon this pathway...
  51. ncbi Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells
    Sean R Conner
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 278:34548-54. 2003
    ..Integrins regulate these processes partially through control of extracellular signal-regulated kinases 1 and 2 (ERK1/2). A trait of malignant cells is their ability to undergo anchorage-independent growth...
  52. pmc The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages
    Brian Tomkowicz
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 108:1145-50. 2006
    ....
  53. pmc Mxi2 promotes stimulus-independent ERK nuclear translocation
    Berta Casar
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas CSIC, Departamento de Biologia Molecular, Unidad de Biomedicina CSIC Universidad de Cantabria, Santander, Spain
    EMBO J 26:635-46. 2007
    Spatial regulation of ERK1/2 MAP kinases is an essential yet largely unveiled mechanism for ensuring the fidelity and specificity of their signals. Mxi2 is a p38alpha isoform with the ability to bind ERK1/2...
  54. ncbi Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells
    Eing Mei Tsai
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung, Taiwan, Republic of China
    Fertil Steril 89:1522-9. 2008
    ..To elucidate the role of RU486 in regulating the function of granulosa luteal cells and its possible involvement in ovarian dysfunction...
  55. pmc Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cancer Res 68:5113-21. 2008
    ..cancer cells to gamma-irradiation (IR) is dependent on the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling...
  56. pmc Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
    Tomas Vomastek
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Mol Cell Biol 28:6954-66. 2008
    ..We propose that Tpr is both a substrate and a scaffold for activated ERKs...
  57. doi Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling
    Jianrong Wang
    Department of Molecular Biology and Genetics, Cornell University, New York 14853, USA
    Eur J Cell Biol 88:103-15. 2009
    ....
  58. pmc Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3
    Angela M Whetzel
    Cardiovascular Research Center, Univ of Virginia, P O Box 801394, 415 Lane Rd, MR5 Rm G123, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 296:C339-45. 2009
    ..Incubation of diabetic NOD endothelial cells (EC) with S1P (100 nmol/l) reduced ERK1/2 phosphorylation by 90%, with no significant changes in total ERK1/2 protein...
  59. pmc Cocaine and human immunodeficiency virus type 1 gp120 mediate neurotoxicity through overlapping signaling pathways
    Honghong Yao
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurovirol 15:164-75. 2009
    ..These findings thus underscore the role of oxidative stress, mitochondrial and MAPK signal pathways in cocaine and HIV gp120-mediated neurotoxicity...
  60. doi Human immunodeficiency virus type 1 Tat modulates proliferation and differentiation of human neural precursor cells: implication in NeuroAIDS
    Mamata Mishra
    Molecular and Cellular Neuroscience, National Brain Research Center, Manesar, Haryana, India
    J Neurovirol 16:355-67. 2010
    ..D1 and the mitogen-activated protein kinase (MAPK) pathway, particularly extracellular signal-related kinase 1/2 (ERK1/2)...
  61. pmc Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions
    Christopher J Caunt
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK BA2 7AY
    J Cell Sci 123:4310-20. 2010
    ..It is, however, dependent upon D-domain binding, highlighting distinct roles of ERK motifs during nuclear targeting...
  62. pmc GLIPR-2 overexpression in HK-2 cells promotes cell EMT and migration through ERK1/2 activation
    Shaoguang Huang
    Department of Clinical Laboratory, Xin Qiao Hospital, Third Military Medical University, Chong Qing, PR China
    PLoS ONE 8:e58574. 2013
    ..increased EGFR expression levels, we found that the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) was highly elevated in the pcDNA3.0-GLIPR-2-transfected group...
  63. pmc p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels
    Victoria Sanz-Moreno
    Departamento de Biologia Molecular, Universidad de Cantabria, Santander 39011, Spain
    Mol Cell Biol 23:3079-90. 2003
    ..this kinase activity can be attributed not to Mxi2 but rather to extracellular signal-regulated kinases 1 and 2 (ERK1/2), which coimmunoprecipitated with Mxi2 both by ectopic expression and in a physiological environment like the ..
  64. pmc Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation
    Adriana Handra-Luca
    Service d Anatomie et de Cytologie Pathologiques, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 83 Boulevard de l hopital, 75634 Paris Cedex 13, France
    Am J Pathol 163:957-67. 2003
    ..These data suggest that deregulation of ERK-1/ERK-2 pathway contributes to mucoepidermoid carcinoma phenotype and, possibly, represents a target for new anticancer drugs...
  65. pmc HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway
    Elena Toschi
    AIDS National Center, Istituto Superiore di Sanita, 00161 Rome, Italy
    Mol Biol Cell 17:1985-94. 2006
    ..Taken together, these data provide novel evidence about the ability of Tat to activate the Ras-ERK cascade which may be relevant for endothelial cell proliferation and for Kaposi's sarcoma progression...
  66. ncbi Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma
    Artit Jinawath
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    J Cancer Res Clin Oncol 132:805-10. 2006
    ..However, the roles of ERK1/2 phosphorylation (pERK1/2) and CDX2 in cholangiocarcinogenesis remain unknown.
  67. ncbi Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibition
    R Dechend
    , , Humboldt University of Berlin, Germany
    Am J Hypertens 14:55S-61S. 2001
    ..Furthermore, NF-kappaB and AP-1 activation was sharply attenuated. We also observed that cerivastatin blocked ERK1/2 phosphorylation in vivo and in vitro...
  68. doi Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia-reperfusion injury in a nuclear factor-kappaB-independent manner
    Letteria Minutoli
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
    Eur J Pharmacol 604:27-35. 2009
    ..These findings should contribute to better understand testicular torsion-induced damage...
  69. ncbi Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation
    J Buteau
    Molecular Nutrition Unit, Department of Nutrition, University of Montreal, the Centre de Recherche du CHUM and Institut du Cancer, Montreal, Quebec, Canada
    Diabetes 50:2237-43. 2001
    ....
  70. ncbi Angiotensin II elevates nitric oxide synthase 3 expression and nitric oxide production via a mitogen-activated protein kinase cascade in ovine fetoplacental artery endothelial cells
    Jing Zheng
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 72:1421-8. 2005
    ..and total NO (NO(x)) production via activation of mitogen-activated protein kinase 3/1 (MAPK3/1, also known as ERK1/2) in OFPAE cells. ANG II elevated (P < 0.05) eNOS protein, but not mRNA levels with a maximum effect at 10 nM...
  71. doi Delayed activation of extracellular-signal-regulated kinase 1/2 is involved in genistein- and equol-induced cell proliferation and estrogen-receptor-alpha-mediated transcription in MCF-7 breast cancer cells
    Huaqing Liu
    The Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University, Jiangsu, Nanjing, China
    J Nutr Biochem 21:390-6. 2010
    The aim of this study was to determine whether the extracellular-signal-regulated kinase 1/2 (ERK1/2) pathway is involved in genistein- and equol-induced cell proliferation and estrogen receptor (ER) alpha transactivation...
  72. ncbi Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
    D F Liao
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 272:6146-50. 1997
    ..The dual specificity mitogen-actived protein (MAP) kinase/ERK kinase (MEK) activates ERK1/2 in response to angII, but the MEK activating kinases remain undefined. Raf is a candidate MEK kinase...
  73. ncbi ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury
    Zhen Xu
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, 710032, PR China
    Life Sci 79:1895-905. 2006
    ..characterize the pathways mediating the synthesis and release of NO, we examined activation of extracellular signal regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (p38 MAPK) in microglia/macrophages in the ..
  74. doi Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38
    Takayuki Nemoto
    Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
    Eur J Pharmacol 640:20-8. 2010
    ..Here, veratridine increased constitutive Tyr204-phosphorylation of extracellular signal-regulated kinase-1/-2 (ERK1/ERK2) and constitutive Thr180/Tyr182-dual phosphorylation of p38 by approximately 118% (EC50=2.8 microM)...
  75. ncbi Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation
    Gerard D'Angelo
    Boston Biomedical Research Institute, Watertown, Massachusetts 02472, USA
    Am J Physiol Heart Circ Physiol 282:H602-10. 2002
    Phosphorylation of the actin-associated protein caldesmon (CaD) by extracellular signal-regulated kinases (ERK1/2) is purported to participate in force maintenance by vascular smooth muscle...
  76. ncbi Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin
    D L Persons
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160 7410, USA
    Clin Cancer Res 5:1007-14. 1999
    ..investigated the response of the mitogen-activated protein kinases, extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun-N-terminal kinase 1 (JNK1), and p38, to cisplatin treatment in the ovarian carcinoma cell line SK-OV-3...
  77. ncbi Different influences of hyperglycemic duration on phosphorylated extracellular signal-regulated kinase 1/2 in rat heart
    Zenya Naito
    Department of Pathology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 0022, Japan
    Exp Mol Pathol 74:23-32. 2003
    ..However, the effect of this glycation on mitogen-activated protein kinases, particularly ERK1/2, in the myocardium is largely unclarified...
  78. ncbi Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
    ..This study investigated the role of ERK1/2 and p38 mitogen-activated protein kinases (MAPK)...
  79. doi Resin monomer-induced differential activation of MAP kinases and apoptosis in mouse macrophages and human pulp cells
    Stephanie Krifka
    Department of Operative Dentistry and Periodontology, University of Regensburg, University Medical Center, Regensburg, Germany
    Biomaterials 31:2964-75. 2010
    ..the aim of the present study to investigate the kinetics of the up- or down-regulation of the MAPK p38, JNK, and ERK1/2, the induction of apoptosis and cytokine release in RAW264.7 mouse macrophages and human pulp-derived cells...
  80. pmc Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits
    M M Belcheva
    E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, Missouri 63104-1079, USA
    J Neurochem 70:635-45. 1998
    ..African green monkey kidney COS-7 cells transiently cotransfected with mu-, delta-, or kappa-opioid receptors and ERK1- or ERK2-containing plasmids...
  81. pmc Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy
    R Patel
    Section of Cardiology, Department of Medicine, The DeBakey Heart Center, The Methodist Hospital and Baylor College of Medicine, Houston, Texas, USA
    Circulation 104:317-24. 2001
    ..CONCLUSIONS: Simvastatin induced the regression of hypertrophy and fibrosis, improved cardiac function, and reduced ERK1/2 activity in the beta-myosin heavy chain-Q(403) rabbits...
  82. ncbi Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes
    M P Sajan
    J. A. Haley Veterans Hospital Research Service, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 274:30495-500. 1999
    ..by insulin to activate the multifunctional intracellular effectors, extracellular signal-regulated kinases 1 and 2 (ERK1/2), are only partly understood and appear to vary in different cell types...
  83. ncbi Modulation of ERK1/2 and p38(MAPK) by lead in the cerebellum of Brazilian catfish Rhamdia quelen
    Rodrigo B Leal
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC 88040 900, Brazil
    Aquat Toxicol 77:98-104. 2006
    ..Extracellular signal-regulated kinases (ERK1/2) and p38(MAPK) control complex programs such as gene expression, embryogenesis, cell differentiation, cell ..
  84. ncbi Identification of signaling molecules mediating corticotropin-releasing hormone-R1alpha-mitogen-activated protein kinase (MAPK) interactions: the critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation
    Anu Punn
    Endocrinology and Metabolism, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 20:3179-95. 2006
    ..Signal transduction of CRH-R1 also involves alternative pathways such as phosphorylation of ERK1/2 and p38 MAPK, two members of the MAPK family that mediate important pathophysiological responses...
  85. ncbi p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Hypertension 37:574-80. 2001
    ..Mechanisms underlying these processes are unclear, but MAP kinases, particularly ERK1/2 and p38 MAP kinase, may be important...
  86. ncbi Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of delta-PKC and ERK1/2
    Laurie E Kilpatrick
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Leukoc Biol 80:1512-21. 2006
    ..signaling pathways are involved in TNF-mediated antiapoptotic signaling; a role for the MAP kinases (MAPK), ERK1/2, and p38 MAPK has been suggested...
  87. ncbi Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway
    Bo Bai
    Department of Neurobiology, Taishan Medical College, Taian 271016, China
    Acta Biochim Biophys Sin (Shanghai) 40:311-8. 2008
    ..signaling to the family of mitogen-activated protein kinases (MAPKs), such as extracellular-regulated kinases 1/2 (ERK1/2) and p38 MAPK, through the coupling of apelin receptor (APJ) to G-protein, mediates important pathophysiological ..
  88. pmc Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway
    Wenhui Hu
    Department of Physiology and Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Physiol Cell Physiol 296:C1310-20. 2009
    ..Here, we show that the activation of various protein kinases, including ERK1/2, p38 MAPK, and phosphoinositide 3-kinase (PI3K), differentially modulates IL-1beta-induced upregulation of RGS4 ..
  89. doi L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    Hung Yun Lin
    Ordway Research Institute, Albany, NY 12208, USA
    Am J Physiol Cell Physiol 296:C980-91. 2009
    ..Although both T(3) and T(4) stimulated extracellular signal-regulated kinase (ERK) 1/2, activated ERK1/2 did not contribute to T(3)-induced Src kinase or PI3-kinase activation, and an inhibitor of PI3-kinase, LY-294002,..
  90. ncbi Activation of extracellular signal-regulated kinases 1 and 2 by insulin-like growth factor I in human osteosarcoma MG-63 cells
    W Lopaczynski
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Horm Metab Res 31:65-9. 1999
    ..Extracellular signal-regulated kinase 2 was found in the nucleus after addition of insulin-like growth factor I...
  91. ncbi [The role of mitogen-activated protein kinase cascades in inhibition of proliferation in human prostate carcinoma cells by raloxifene: an in vitro experiment]
    Yu xi Zhang
    Department of Urology, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 88:271-5. 2008
    ..To investigate the role of mitogen-activated protein kinase (MAPK) in the apoptosis and cell cycle arrest of human prostate carcinoma cells induced by raloxifene (RAL)...
  92. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
    ..In both cells the effect was due to ERK1/2 activation (p42 > p44 in GC; p42 = p44 in RC). MAPK activation was dependent on PKC, but not protein kinase A...
  93. ncbi Role of Galphaq in smooth muscle cell proliferation
    William John Tanski
    Division of Vascular Surgery, Department of Surgery, University of Rochester, Rochester, NY 14642, USA
    J Vasc Surg 39:639-44. 2004
    ..G protein-linked receptors are involved in the processes that lead to intimal hyperplasia. This study examined the role of Galphaq signaling pathways in vascular smooth muscle cell (SMC) proliferation in vitro...
  94. doi Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases
    Daniela A Eisinger
    Institute of Pharmacology, Toxicology and Pharmacy, University of Munich, Koniginstrasse 16, D 80539 Munchen, Germany
    Cell Signal 20:2324-31. 2008
    Integrin-mediated cell adherence to extracellular matrix proteins results in stimulation of ERK1/2 activity, a mechanism involving focal adhesion tyrosine kinases (pp125FAK, Pyk-2) and epidermal growth factor receptors (EGFRs)...
  95. pmc Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways
    K Wang
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, WI 53715, USA
    Placenta 30:1045-51. 2009
    ..via the mitogen-activated protein kinase kinase 1/2 (MEK1/2)/extracellular signal-regulated kinases 1/2 (ERK1/2) and phosphatidylinositol-3 kinase (PI3K)/v-akt murine thymomaviral oncogene homologue (AKT1) pathways in human ..
  96. pmc Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis
    Gretchen A LaRusch
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 115:5111-20. 2010
    ..FXII (3-62nM) with 0.05mM Zn(2+) induces extracellular signal-related kinase 1/2 (ERK1/2; mitogen-activated protein kinase 44 [MAPK44] and MAPK42) and Akt (Ser473) phosphorylation in endothelial cells...
  97. ncbi Troglitazone inhibits angiotensin II-induced extracellular signal-regulated kinase 1/2 nuclear translocation and activation in vascular smooth muscle cells
    S Goetze
    University of California, Los Angeles, School of Medicine, Division of Endocrinology, Diabetes and Hypertension, 90095, USA
    FEBS Lett 452:277-82. 1999
    ....
  98. ncbi Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells
    Yoshifumi Kawanabe
    Department of Neurosurgery, Kyoto University Faculty of Medicine, Kyoto 606 8397, Sakyo, Japan
    Eur J Pharmacol 435:119-23. 2002
    ..We focused on extracellular signal-regulated kinase 1 and 2 (ERK1/2) in this context...
  99. ncbi [Ischemic postconditioning protects hypertrophic myocardium by ERK1/2 signaling pathway: experiment with mice]
    Xiao Mei Li
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
    Zhonghua Yi Xue Za Zhi 89:846-50. 2009
    ..the effects of ischemic postconditioning (IPost) in protecting hypertrophic myocardium subjected to ischemic-reperfusion (I/R) and to study the role of extracellular regulated protein kinase (ERK1/2) in mediating such protection.
  100. ncbi Adenovirus-mediated overexpression and stimulation of the human angiotensin II type 2 receptor in porcine cardiac fibroblasts does not modulate proliferation, collagen I mRNA expression and ERK1/ERK2 activity, but inhibits protein tyrosine phosphatases
    C Warnecke
    Department of Internal Medicine Cardiology, Charite, Campus Virchow Clinic, Humboldt University, Forschungshaus 37, Augustenburger Platz 1, 13353 Berlin, Germany
    J Mol Med (Berl) 79:510-21. 2001
    ..Ang II stimulation of the endogenous AT1R increased extracellular signal regulated kinase 1/2 activities. This response was reduced by Irbesartan, but PD123319 had no effect...
  101. ncbi Phosphatidylinositol 3-kinase and ERK1/2 are not involved in adenosine A1, A2A or A3 receptor-mediated preconditioning in rat ventricle strips
    Laura Button
    School of Biomedical and Natural Sciences, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
    Exp Physiol 90:747-54. 2005
    Mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase 1 and 2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3-kinase)/protein kinase B (PKB; also known as Akt) are important antiapoptotic signalling pathways ..

Research Grants90

  1. Renate B Pilz; Fiscal Year: 2014
    ..loading of bone induces fluid shear stress (FSS), which stimulates Src and the mitogen- activated protein kinases Erk1/2 leading to increased osteoblast/cyte proliferation and survival...
  2. Cannabinoids and Neuroimmune Interactions
    Edgar Alfonso Romero Sandoval; Fiscal Year: 2010
    ..The development of new drug strategies to treat acute and chronic pain safely and effectively will result in an invaluable improvement for millions of patients. ..
  3. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
    ..We will investigate;1) the regulatory mechanism of Rac and ERK1/2 on mitogenic pathway in response to FGF-2 stimulation;and 2) the molecular mechanism by which IL-1b induces FGF-2...
  4. Metastatic protein network in BRAFV600E positive human thyroid cancers
    Carmelo Nucera; Fiscal Year: 2013
    ..in BRAFV600E-positive PTC and ATC cells and knockdown of TSP-1 significantly decreases levels of phospho(p)-ERK1/2, pFAK, and integrins...
  5. Winston E Thompson; Fiscal Year: 2014
    ..PHB1 is phosphorylated on Y249 in a MEK1-dependent fashion while PHB1 is required for ERK1/2 activation defining a new regulatory paradigm in response to FSH+T in primary GCs...
  6. Potential of a dominant-negative FGF mutant as a therapeutic in cancer
    Yoshikazu Takada; Fiscal Year: 2012
    ..Tyr phosphorylation of the integrin 23 cytoplasmic domain, but R50E did not;and 3) wt FGF1 induced sustained ERK1/2 activation, but R50E did not...
  7. The role of PKD3 in prostate carcinogenesis
    Qiming Jane Wang; Fiscal Year: 2013
    ..prostate cancer development via a novel signaling pathway involving PKC5/PKD3-mediated activation of Akt and ERK1/2...
  8. Ronald B Gartenhaus; Fiscal Year: 2015
    ..We previously showed that inhibition of tumor MEK and ERK1/2 phosphorylation by 1st generation MEK and ERK pharmacologic inhibitors (or shRNA knockdowns) resulted in cell ..
  9. TAMMY ANGALINE BUTTERICK; Fiscal Year: 2016
    ..OxA has been shown to activate extracellular signal-regulated kinases 1/2 (ERK1/2) and p38 mitogen activated phosphate kinase (MAPK) in various cell models...
  10. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  11. EGF Receptor Signaling in Time and Space in Tumor Cells
    Alexander D Sorkin; Fiscal Year: 2012
    ..Activation of the mitogen-activated protein kinase 1/2 (MAPK/ERK1/2) is the major signaling pathway triggered by EGFR, which determines the ultimate outcome of the EGFR signaling...
  12. Receptor-mediated actions of renin in kidney fibrosis
    Yufeng Huang; Fiscal Year: 2012
    ..profibrotic proteins, 2) Binding of renin to this receptor activates the mitogen-activated protein kinase-1 and -2 (ERK1 &ERK2) and subsequent signaling that leads to TGF-IJ induction...
  13. HUIPING ROSE ZHOU; Fiscal Year: 2015
    ..We have previously reported that conjugated bile acids activate the AKT and ERK1/2 pathways via G[unreadable]i protein coupled receptor(s)...
  14. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..RANKL appears to be regulated via ERK1/2 and STAT3 phosphorylation...
  15. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..regulator of osteoclasts through differential regulation of the various Rho GTPases and through suppression of the Erk1/2-c-Fos-NFAT1c cascade...
  16. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..that a key mediator is the tyrosine kinase c-Src, which phosphorylates phospholipase-C3 (PLC3) and activates the ERK1/2 pathway...
  17. Cecilia M Giachelli; Fiscal Year: 2014
    ..Furthermore, Erk1/2 signaling was required for SMC osteochondrocytic phenotype change in vitro...
  18. Brian P Head; Fiscal Year: 2014
    ..only a multitude of receptors including NMDAR, AMPAR, GPCRs, and TrkR, but also signaling molecules such as Src and ERK1/2 and those that regulate cAMP formation...
  19. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    ..Brain TNFa expression, on the other hand, was reduced and ERK1/2 phosphorylation trended in the same direction...
  20. ISTVAN STEVEN BOLDOGH; Fiscal Year: 2014
    ..increased the levels of 1) activated small GTPases;2) Ras to Raf-1 binding;and phosphorylation of 3) MEK1,2;4) ERK1,2;and 5) RelA-Ser276. EG8-oxoG induced luciferase expression driven from the CXCL-8 promoter...
  21. Zhong Yin Zhang; Fiscal Year: 2014
    ..SHP2 is required for Ras/ERK1/2 activation downstream of most receptor tyrosine kinases, cytokine receptors, and integrins...
  22. Hui Cai; Fiscal Year: 2016
    ..We also found that WNK4 enhanced ERK1/2 phosphorylation, whereas knock-down of WNK4 reduced ERK1/2 phosphorylation...
  23. HING HUNG HENRY LAI; Fiscal Year: 2016
    ..shown that activation of metabotropic glutamate receptor subtype 5 (mGluR5) and its downstream signaling targets, ERK1/2 (extracellular signal-regulated kinases), in spinal cord dorsal horn increases the excitability of the spinal ..
  24. RENNY THEODORE FRANCESCHI; Fiscal Year: 2016
    ..hypothesis is proposed to explain how this is accomplished: i) After exposure to an osteogenic stimulus, P-ERK1/2 translocates to the nucleus and binds chromatin of osteoblast target genes via specific docking sites on Runx2...
  25. Francis Young In Lee; Fiscal Year: 2015
    ..LPS induced phosphorylation of ERK1/2, a common inflammatory osteolysis signal transducer, was also inhibited via LPS treatment...
  26. The Inositol Phosphate Cascade as a Regulator of FSH and LH actions in the Ovary
    Shawn M Breen; Fiscal Year: 2012
    ..of inositol phosphates and diacylglycerol leading to the release of epiregulin and phosphorylation of EGFR and ERK1/2...
  27. MANIPULATION OF KINASE ACTIVITY BY KSHV LANA
    S Diane Hayward; Fiscal Year: 2010
    ..is LANA mediated inactivation of the serine/threonine kinase GSK-3 and activation of the serine/threonine kinase ERK1/2...
  28. RECEPTOR INTERACTION WITH GTP-REGULATORY PROTEINS
    Gary L Johnson; Fiscal Year: 2012
    ..Our hypothesis is that MEKK1 functions to stimulate the activity of specific MAPK pathways (primarily JNK and ERK1/2), coordinately regulate the degradation of specific target substrates (e.g...
  29. Donita C Brady; Fiscal Year: 2015
    ..evolved from our previous observations that copper (Cu) influx enhances MEK1 phosphorylation of its substrates ERK1/2 through a Cu-MEK1 interaction...
  30. Anthony Brown; Fiscal Year: 2016
    ..We propose that phosphorylation of neurofilaments by CDK5 and ERK1/2 kinases regulates their transport in an additive and dose-dependent manner by increasing the proportion of the ..
  31. Zhong Yin Zhang; Fiscal Year: 2016
    ..expressed and positively regulates signaling from receptor tyrosine kinases through the activation of the Ras/ERK1/2 cascade...
  32. Dopamine Signaling Mechanisms of Traumatic Brain Injury
    C Edward Dixon; Fiscal Year: 2013
    ..particular, DARPP-32 phosphorylation at Thr34 is an important mediator of the cAMP-extracellular regulated kinase (ERK1/2) pathway, acting as an inhibitor of protein phosphatase 1 (PP1)...
  33. Programmed Adipogenesis and Lipid Dysregulation
    Mina Desai; Fiscal Year: 2009
    ..co- repressor, NCoR, (ii) increased co-activator, SRC1, and (iii) reduced inhibition of PPAR[unreadable]2 via ERK1/2-mediated phosphorylation. These may all contribute to PPAR[unreadable]-mediated programmed adipogenesis...
  34. Allyn C Howlett; Fiscal Year: 2014
    ..activated protein kinase (MAPK), leading to phosphorylation pathways regulated by protein kinase A (PKA) and ERK1/2. The aims are to: 1. Characterize the signal transduction dependence on the juxtamembrane C-terminal domain...
  35. Cytochrome P450 Eicosanoids and Myocardial Injury
    GARRETT JOHN GROSS; Fiscal Year: 2012
    ..will investigate the down stream signaling pathways of EGFR activation by EETs, including the PKC/Akt/TK, p38, or ERK1/2 pathways...
  36. Brian P Head; Fiscal Year: 2015
    ..increases MLR, NMDAR, AMPAR, and TrkR;3) Cav-1 enhances BDNF-mediated phosphorylation of TrkR, Akt, and ERK1/2;4) enhances NMDAR-mediated activation of P-Src, P-CaMKII, and P-ERK1/2;5) increases NMDAR, Dopamine 1 receptor (..
  37. Sanjay Gupta; Fiscal Year: 2014
    ..targets of apigenin action include phosphatidylinositol 3-kinase (PI3K), protein kinase B/Akt, classical MAPK/ERK1/2, and cyclin-dependent kinases...
  38. S MURTHY KARNAM; Fiscal Year: 2016
    ..of sGC and ACIII leading to inhibition of cGMP and cAMP synthesis, and (ii) up-regulation of PDE1A1 via NF-?B, and ERK1/2- mediated activation of PDE4D5, leading to augmentation of cGMP and cAMP degradation...
  39. Defining mechanisms of MEK1/2 inhibitor response in triple negative breast cancer
    Martin Whittle; Fiscal Year: 2013
    ..growth- promoting receptor tyrosine kinases, such as PDGFRb, are induced to offset MEK1/2 inhibition and reactivate ERK1/2...
  40. Adenosine Receptors and Restoration of Salivary Gland in Sjogren's Syndrome
    Umesh S Deshmukh; Fiscal Year: 2013
    ..To determine direct effects of AR agonists on salivary glands, Ca2+ mobilization and phosphorylation of ERK1/2 in submandibular gland acini will be monitored...
  41. PTH-Induced Endocytosis of TbetaRII/PTH1R as a Complex
    Xu Cao; Fiscal Year: 2013
    ..Consequently, cAMP production, PKC and ERK1/2 activities are down-regulated...
  42. Sammanda Ramamoorthy; Fiscal Year: 2014
    ..Our studies show that KOR activation increases DAT activity through ERK1/2 dependent phosphorylation of threonine (Thr)53 of DAT and selective inhibition of ERK1/2 in the VST attenuates ..
  43. Targeting RON Receptor Signaling in Pancreatic Cancer
    Andrew M Lowy; Fiscal Year: 2010
    ..Preliminary studies suggest this compound can prevent HGFL-induced phosphorylation of AKT and ERK1/2...
  44. Louis M Luttrell; Fiscal Year: 2016
    ..Our research originally focused on GPCR regulation of the ERK1/2 MAP kinase cascade...
  45. A Murine Model of Chronic Autoimmune Hepatitis and Liver Fibrosis
    XIAOPING ZHONG; Fiscal Year: 2012
    ..expressed in T cells, negatively control T cell activation by inhibiting T cell receptor (TCR)-induced Ras and Erk1/2 activation...
  46. Marie Demay; Fiscal Year: 2015
    ..Phosphate induces Erk1/2 phosphorylation and activates the mitochondrial apoptotic pathway in hypertrophic but not proliferative ..
  47. IL3 GROWTH FACTOR SIGNALING
    William Stratford May; Fiscal Year: 2010
    ..Dynamic (reversible) Bcl2 phosphorylation is regulated by multiple Bcl2 kinases (i.e. PKC alpha, ERK1/2 and JNK1) and a physiological Bcl2 phosphatase (PP2A)...
  48. Brian C Betts; Fiscal Year: 2016
    ..Aim 3) Determine if the pSTAT5/pSTAT3 ratio or ERK1/2 phosphorylation in CD4+ or CD8+ T cells on day +21 associate with the development of acute GvHD before day +100...
  49. Buprenorphine effects on oligodendrocyte development and axonal growth
    Carmen Sato Bigbee; Fiscal Year: 2010
    ..cells, including neurofilament accumulation, spacing and phosphorylation, and the local distribution of Cdk5 and ERK1/2, two major kinases involved in neurofilament phosphorylation ...
  50. Anton M Bennett; Fiscal Year: 2015
    ..much work has established that enhanced activation of the Ras/extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway is causal to NS-mediated CHD the precise mechanisms through which NS-associated SHP-2 mutations engage ..
  51. XIAOPING ZHONG; Fiscal Year: 2016
    ..in T cells, negatively control T cell activation by inhibiting TCR-induced activation of the DAG-RasGRP1-Ras-Erk1/2-AP1 cascade...
  52. Targeting of B-AR/GBy signaling in the heart with small molecules
    Burns C Blaxall; Fiscal Year: 2013
    ..Pathologic cardiac G?? signaling was recently found to interact with and result in novel, sustained ERK1/2 phosphorylation at T188;this sustained phosphorylation event has been directly associated with HF...
  53. Jing Zhang; Fiscal Year: 2016
    ..unlike in HSPCs and other progenitors, we found that Nras G12D signaling constitutively hyperactivates ERK1/2 in HSCs in a dose-dependent manner...
  54. Cell Type Specific Control of Neuronal Signaling
    MARTILIAS STEPHEN FARRELL; Fiscal Year: 2012
    ..whether the G-alpha-s DREADD activates canonical G-alpha-s signaling pathways by measuring cAMP accumulation, ERK1/2 phosphorylation, DARPP-32 phosphorylation, and c-Fos expression...
  55. ROBERT GEREAU; Fiscal Year: 2014
    ..This pathway is initiated by mGlu5 activation of extracellular signal-regulated kinase (ERK1/2) signaling, leading to phosphorylation of a Kv4...
  56. Robert S Hoover; Fiscal Year: 2015
    ..Preliminary data demonstrates the role of the ERK1/2 MAPK (Extra-cellular signal-Regulated Kinases 1 and 2 Mitogen-Activated Protein Kinases) pathway in the ..
  57. Role of ERK1/2 in Neuromuscular Synapses and Myofiber Development in vivo
    Mendell Rimer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Extracellular-signal regulated kinases 1 and 2 (ERK1/2) are the prototypical intracellular mitogen activated protein kinases (MAPK)...
  58. Melanie H Cobb; Fiscal Year: 2016
    ..ERK2 has long served as a prototype to define properties of MAPKs and their cascades. ERK2 and/or ERK1 are required not only for embryogenesis, differentiation, and proliferation, but also for events in differentiated ..
  59. RGS12 as a MAPK Scaffold in Muscle Development and Disease
    EMILY ANNE OESTREICH; Fiscal Year: 2012
    ..In a skeletal myoblast/satellite cell model (C2C12 cells), H-Ras and ERK1/2 activation promote proliferation and inhibit myotube formation, whereas rapid inactivation of ERK1/2 is necessary ..
  60. ERK Mitogen Activated Protein Kinases in Skeletogenesis
    Edward M Greenfield; Fiscal Year: 2012
    ..We hypothesize that 1) Krox20 expression is regulated by ERK1/ERK2 through its MAPK response element via DNA binding complex containing direct ERK1/ERK2 substrates, 2) ERK1 and ..
  61. Navdeep S Chandel; Fiscal Year: 2015
    ..ROS have been proposed to serve as signaling molecules to activate numerous signaling pathways, including PI3K, ERK1/2 MAPK, and the transcription factors hypoxia inducible factors (HIFs), which promote tumor cell proliferation, ..
  62. Nicholas F Larusso; Fiscal Year: 2016
    ..miR-15a via transcriptional activation of the CREB/ICER/CRE pathway causing miR-15a target proteins (Cdc25A, Ptc, Erk1) to increase leading to hyperproliferation;and (iii) pharmacologic targeting of MEK, Smo and Cdc25A, components of ..
  63. ESTROGEN AND ENDOTHELIAL MIGRATION AND DIFFERENTIATION
    H Schnaper; Fiscal Year: 2002
    ..Moreover, 17b-estradiol stimulates activity of the p44mapk/p42mapk (ERK1/2) MAP kinases in endothelial cells by stimulating production and release of the autocrine hormone, ..
  64. B-RAF Regulation of the Cell Cycle in Melanoma
    Andrew E Aplin; Fiscal Year: 2013
    ..Mutant B-RAF signaling in human melanoma cells elevates activation of the MEK-ERK1/2 pathway and regulates two key G1 cell cycle proteins: cyclin D1 and p27Kip1...
  65. John R Grider; Fiscal Year: 2016
    ..to identify the receptors (TrkB, p75, and sortilin) and intracellular signaling pathways (PLC-gamma, PI-3-K/AKT, ERK1/2, Rho/Rock) activated by proBDNF and mBDNF, that are involved in the enhancement of peristalsis and/or inhibition ..
  66. HUA LINDA CAI; Fiscal Year: 2016
    ..netrin-1 is equally robust in inducing cardioprotection in vivo and whether the protection is mediated by a DCC-ERK1/2-deepdent activation of eNOS /nitric oxide (NO") in cardiac microvascular endothelial cells that should be ..
  67. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..and we reported on MIF's ability to override glucocorticoid immunosuppression, induce sustained activation of ERK1/2 MAP kinases, and promote inflammation by inhibiting activation-induced apoptosis...
  68. Nicole Salazar; Fiscal Year: 2014
    ..BrCa cell lines, depletion of which causes cell cycle arrest and reduced activation of MAP kinases, such as ERK1/2...
  69. Nada A Abumrad; Fiscal Year: 2016
    ..CD36's ability to transduce signals to the src kinase and downstream to the extracellular regulated kinase (ERK1/2). The CD36-ERK pathway is activated in a lipid- dependent manner during early stages of chylomicron formation...
  70. EVA NOZIK GRAYCK; Fiscal Year: 2016
    ..activates TGF-[unreadable];and if this is responsible for ERK1/2 activation, Egr-1 expression and the subsequent changes in growth, inflammation and synthetic properties of PASMC...
  71. David Kuhrt; Fiscal Year: 2015
    ..SPECIFIC AIM 2 will investigate Trib'3 molecular action mechanisms, including regulation of Erk1,2 and Akt signaling, and action as a putative E3 ubiquitin ligase adaptor...
  72. Yogesh Dwivedi; Fiscal Year: 2016
    ..implications in the neurobiology of suicide, we propose to test the hypothesis that hypoactive BDNF/TrkB-mediated ERK1/2 and PI3K/Akt and overexpressed p75NTR will lead to modifications in the interaction and activation of downstream ..
  73. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia L Zhuo; Fiscal Year: 2013
    ..the expression and the activity of NHE-3 in AP membranes via the activation of [Ca2+]i/PKC1/2II, MAP kinases ERK1/2, and NF-:B signaling pathways...
  74. Rashmi Bansal; Fiscal Year: 2016
    ..AIM I we will determine whether attenuated myelin growth in the Fgfr1/2 KO can be rescued by genetically elevating ERK1/2 activity in OLs, to test if the two are functionally linked in the in vivo context...
  75. Julio A Aguirre-Ghiso; Fiscal Year: 2016
    ..These depend on the signaling balance between ERK1/2 (mitogenic) and p38a/b (stress) pathways and a specific downstream gene expression program...
  76. JOAN THERESE RICHTSMEIER; Fiscal Year: 2016
    ..g., Erk1/2, p38) and identify novel pathways...
  77. Zheng W Chen; Fiscal Year: 2015
    ..more activated as they expressed much higher levels of phosphorylated signaling molecules p38, stat3, stat5, and Erk1/2 than Tim-3- controls...
  78. Thomas Y Ma; Fiscal Year: 2016
    ..that the TNF-[unreadable] induced increase in intestinal epithelial TJ permeability was regulated in part by ERK 1/2 and p38 signaling cascade induced increase in myosin light chain kinase (MLCK) gene activity and microRNA ..
  79. Timothy McKinsey; Fiscal Year: 2016
    ..Our preliminary data indicate that class I HDACs alter nuclear ERK1/2 signaling in cardiomyocytes by inducing expression of an ERK-specific phosphatase, DUSP5...
  80. Alan G Watts; Fiscal Year: 2016
    ..will target CRH synthesis and release, including changes in neuronal spike frequencies, CRH hnRNA, phospho-ERK1/2, phospho-CREB, and circulating ACTH...
  81. CXCL8-mediated glial cross-talk and neuroprotection in HIV-1 Dementia
    Anuja Ghorpade; Fiscal Year: 2013
    ..The mechanisms of CXCL8 neuroprotection and the ensuing signal transduction specifically through Akt/PKB, ERK1/2, Bcl-2 and Bax and the role of TNF receptors in these neuroprotective events will be investigated using primary ..
  82. Subhash C Pandey; Fiscal Year: 2016
    ..signaling [cAMP responsive-element binding protein (CREB) and extracellular regulated protein kinases 1/2 (Erk1/2)] are regulated and if BDNF signaling modulates synaptic plasticity in the amygdala resulting in the phenotypes ..
  83. CRAIG BARCUS; Fiscal Year: 2015
    ..of PRL receptors with beta-integrins and lipid rafts, driving tumorigenic PRL actions through the FAK-SFK-ERK1/2 pathway...
  84. Breast cancer response markers to a dual HER1/2 blocker
    Jenny Chang; Fiscal Year: 2009
    ..We hypothesize that a small molecule like GW572016 which inhibits both Akt/PI3-kinase cell survival and ERK 1,2 MAP-kinase cell proliferation pathways by blocking HER1 and HER2...
  85. Rashmi Bansal; Fiscal Year: 2014
    ..the important question of how myelin assembly and maintenance are regulated in the CNS, hypothesizing that ERK1/2-MAPK (Extracelluar Signal Regulated Kinases-1/2), important mediators of multiple external signals, plays a ..
  86. Mario Strazzabosco; Fiscal Year: 2016
    ..produces VEGF and expresses its cognate receptor VEGFR2;2) VEGF-mediated stimulation of VEGFR2 results in increased ERK1/2-dependent proliferation of the cystic epithelium, 3) PC2-defective cystic cholangiocytes, altered cellular Ca2+ ..
  87. Andrew E Aplin; Fiscal Year: 2016
    ..Mutant B- RAF hyper-activates MEK-ERK1/2 signaling and is required for melanoma growth and invasion...
  88. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2007
    ..e., phosphorylation states of 4E-BPI and p70S6K) and the phosphorylation of ERK1/2 and GSK3, 2 other pathways through which IGF-1 could act...
  89. BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTES
    Sheila Collins; Fiscal Year: 2003
    ..coupled to both Galphas and Galphai, leading to the activation of the protein kinase A (PKA) and MAP kinase (ERK1/2) pathways, respectively ERK1/2 activation is sensitive to pertussis toxin, dependent upon an activated receptor ..
  90. Signaling mechanisms underlying VEGF-induced neuroprotection in vivo
    Susan Croll; Fiscal Year: 2007
    ..VEGF's protective effects in this system are prevented by blocking the PKA-ERK1/2 and Akt (PKB) signaling pathways (unpublished data)...