ERCC2

Summary

Gene Symbol: ERCC2
Description: ERCC excision repair 2, TFIIH core complex helicase subunit
Alias: COFS2, EM9, TFIIH, TTD, TTD1, XPD, TFIIH basal transcription factor complex helicase XPD subunit, BTF2 p80, CXPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, TFIIH 80 kDa subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH basal transcription factor complex helicase XPB subunit, TFIIH basal transcription factor complex helicase subunit, TFIIH p80, basic transcription factor 2 80 kDa subunit, excision repair cross-complementation group 2, excision repair cross-complementing rodent repair deficiency, complementation group 2, xeroderma pigmentosum complementary group D, xeroderma pigmentosum group D-complementing protein
Species: human

Top Publications

  1. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
  2. ncbi DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    G Matullo
    ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Carcinogenesis 27:997-1007. 2006
  3. ncbi Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 631:101-10. 2007
  4. ncbi Polymorphisms in DNA repair and metabolic genes in bladder cancer
    Somali Sanyal
    Department of Biosciences at Novum, Karolinska Institute, S 14157 Huddinge, Sweden
    Carcinogenesis 25:729-34. 2004
  5. ncbi Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients
    Jenny Chang-Claude
    Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:4802-9. 2005
  6. doi Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population
    Wenting Wu
    State Key Laboratory of Genetic Engineering and Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, China
    Clin Cancer Res 15:3889-95. 2009
  7. ncbi Lack of influence of XRCC1 and XPD gene polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancers
    Cheng Yun Yao
    Department of Chemotherapy, Jiangsu Cancer Hospital and Research Institute, Nanjing, China
    Asian Pac J Cancer Prev 10:859-64. 2009
  8. ncbi Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
  9. doi Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity
    Oliver Zschenker
    Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Radiother Oncol 97:26-32. 2010
  10. ncbi Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer
    Surya Ramachandran
    Department of Molecular Medicine, Regional Cancer Centre, Thiruvananthapuram 695 011, India
    Oral Oncol 42:350-62. 2006

Research Grants

  1. John A Tainer; Fiscal Year: 2015
  2. The Meningioma Consortium: Genome-Wide Association Study
    Elizabeth B Claus; Fiscal Year: 2013
  3. WORKER GENETIC SUSCEPTIBILITY TO MUTAGENIC RISK
    Paul W Brandt-Rauf; Fiscal Year: 2013
  4. Bennett Van Houten; Fiscal Year: 2016
  5. DNA Repair, Skin Cancer and Overall Cancer Risk
    Anthony Alberg; Fiscal Year: 2009
  6. PAUL KHAVARI; Fiscal Year: 2016
  7. Alan M Weiner; Fiscal Year: 2014
  8. SUSAN THOMAS LOVETT; Fiscal Year: 2016
  9. CELLULAR AND MOLECULAR RESPONSE TO DNA REPAIR DEFICIENCY
    Renee Reijo Pera; Fiscal Year: 2000
  10. The role of DNA repair in retroviral infection
    KRISTINE E contact YODER; Fiscal Year: 2010

Detail Information

Publications308 found, 100 shown here

  1. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
    ..polymorphisms (SNPs) in 20 DNA repair genes including nucleotide excision repair (NER) genes XPA, ERCC1, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG; base excision repair (BER) genes APE1/APEX, OGG1, MPG, XRCC1, PCNA, POLB, POLiota, ..
  2. ncbi DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    G Matullo
    ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Carcinogenesis 27:997-1007. 2006
    ..47, 95% CI = 1.02-6.02) in the leukaemia group. Our results also suggest that the XPD/ERCC1-GAT haplotype may modulate leukaemia (OR = 1.28, 95% CI = 1.02-1.61), bladder cancer (OR = 1.38, 95% CI = 1...
  3. ncbi Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 631:101-10. 2007
    ..XRCC1 -77 T/C, Arg194Trp, Arg280His and Arg399Gln; APE1 Asp148Glu; OGG1 Ser326Cys; XPA -4 G/A; XPC PAT; XPD Asp312Asn and Lys751Gln) with lung cancer risk in Caucasians...
  4. ncbi Polymorphisms in DNA repair and metabolic genes in bladder cancer
    Somali Sanyal
    Department of Biosciences at Novum, Karolinska Institute, S 14157 Huddinge, Sweden
    Carcinogenesis 25:729-34. 2004
    ..bladder cancer with genetic polymorphisms in the xeroderma pigmentosum complementation group C (XPC), group D (XPD) and group G (XPG), X-ray repair cross-complementing group 1 (XRCC1) and group 3 (XRCC3), Nijmegen breakage ..
  5. ncbi Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients
    Jenny Chang-Claude
    Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:4802-9. 2005
    ..We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg194Trp, Arg280His, and Arg399Gln), APE1 (Asp148Glu), and XPD (Lys751Gln and Asp312Asn), with the risk of acute skin reactions following radiotherapy.
  6. doi Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population
    Wenting Wu
    State Key Laboratory of Genetic Engineering and Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, China
    Clin Cancer Res 15:3889-95. 2009
    Platinum agents cause DNA cross-linking and adducts. Xeroderma pigmentosum group D (XPD) plays a key role in the nucleotide excision repair pathway of DNA repair...
  7. ncbi Lack of influence of XRCC1 and XPD gene polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancers
    Cheng Yun Yao
    Department of Chemotherapy, Jiangsu Cancer Hospital and Research Institute, Nanjing, China
    Asian Pac J Cancer Prev 10:859-64. 2009
    ..This study was conducted to assess relationships between X-ray repair cross complementing group1 (XRCC1) and xeroderma pigmentosum group D (XPD) genetic polymorphisms and outcome in NSCLC patients.
  8. ncbi Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
    ..We studied single nucleotide polymorphisms (SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG, RAD23B and XPC) involved in NER in a population-based case-control study of lung cancer ..
  9. doi Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity
    Oliver Zschenker
    Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Radiother Oncol 97:26-32. 2010
    To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position -509), XPD (codon 751), and XRCC1 (codon 399) with fibrosis and also individual radiosensitivity.
  10. ncbi Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer
    Surya Ramachandran
    Department of Molecular Medicine, Regional Cancer Centre, Thiruvananthapuram 695 011, India
    Oral Oncol 42:350-62. 2006
    ..The distribution of single nucleotide polymorphisms (SNPs) in DNA repair genes XRCC1 and XPD in 110 oral carcinoma cases, 84 leukoplakia and 110 controls belonging to the Travancore South Indian population ..
  11. ncbi A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription
    J R Hwang
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, 1 rue Laurent Fries, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    J Biol Chem 271:15898-904. 1996
    XPB is a subunit of the basal transcription factor TFIIH, which is also involved in nucleotide excision repair (NER) and potentially in cell cycle regulation...
  12. ncbi Effect of DNA repair gene polymorphisms on BPDE-DNA adducts in human lymphocytes
    Roberta Pastorelli
    Laboratory of Molecular Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Cancer 100:9-13. 2002
    ..in DNA repair genes are related to host DNA damage, we investigated the association between polymorphism in the XPD gene (codon 199, 312, 751) and the XRCC1 gene (codon 194, 399) and the presence of benzo(a)pyrene diolepoxide ..
  13. ncbi DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 128:1084-8. 2002
    To determine the effect of the ERCC1 C8092A polymorphism and the ERCC2/XPD G23591A polymorphism on the risk of squamous cell carcinoma of the head and neck (SCCHN).
  14. ncbi Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients
    R de Las Peñas
    Hospital Provincial de Castellón, Castellon, Spain
    Ann Oncol 17:668-75. 2006
    ..polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide reductase, TP53, cyclooxygenase-2, ..
  15. ncbi PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms
    Blanka Binkova
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, Videnska 1083, 14220 Prague, Czech Republic
    Mutat Res 620:49-61. 2007
    ..Polymorphisms of metabolizing (GSTM1, GSTP1, GSTT1, EPHX1, CYP1A1-MspI) and DNA repair (XRCC1, XPD) genes were determined by PCR-based RFLP assays...
  16. pmc Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer
    J Chang-Claude
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 100:1680-6. 2009
    ..Polymorphisms in genes involved in DNA repair (APEX1, XRCC1, XRCC2, XRCC3, XPD) and damage response (TP53, P21) were determined...
  17. doi DNA repair gene ERCC2 polymorphisms and risk of squamous cell carcinoma of the head and neck
    Markus Gugatschka
    ENT University Hospital Graz, Medical University Graz, Austria
    Exp Mol Pathol 91:331-4. 2011
    ..Aim of the following study was to analyze the genetic association of single nucleotide polymorphisms (SNP) of the DNA repair genes with the risk of squamous cell carcinoma of the head and neck (HNSCC)...
  18. pmc Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics
    David R Gandara
    University of California Davis Cancer Center, 4501 X St, Suite 3017, Sacramento, CA 95817 2229, USA
    J Clin Oncol 27:3540-6. 2009
    ..Genotypic variants of CYP3A4, CYP3A5, CYP2C8, NR1I2-206, ABCB1, ERCC1, and ERCC2 were analyzed by pyrosequencing or by PCR restriction fragment length polymorphism...
  19. pmc Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG)
    Mehmet Guven
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Mol Vis 13:12-7. 2007
    ..the frequency of polymorphisms in two DNA repair enzyme genes, Xeroderma pigmentosum complementation group D (XPD) codon 751 and X-ray cross-complementing group 1 (XRCC1) codon 399, in a sample of Turkish patients with POAG, and ..
  20. ncbi Polymorphisms of DNA repair genes XPD and XRCC1 and risk of cataract development
    Mustafa Unal
    Department of Ophthalmology, Akdeniz University Medical Faculty, Antalya, Turkey
    Exp Eye Res 85:328-34. 2007
    ..the frequency of polymorphisms in two DNA repair enzyme genes, xeroderma pigmentosum complementation group D (XPD) codon 751 and X-ray cross-complementing group 1 (XRCC1) codon 399, in a sample of Turkish patients with maturity ..
  21. doi Influence of XPD and APE1 DNA repair gene polymorphism on bladder cancer susceptibility in north India
    Ruchika Gangwar
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Urology 73:675-80. 2009
    To explore the association between xerodema pigmentosum group D (XPD) Asp(312)Asn and Lys(751)Gln and apurinic apyrimidic endonuclease 1 (APE1) Asp(148)Glu gene polymorphism and risk of bladder cancer (BC) susceptibility.
  22. ncbi DNA damage recognition during nucleotide excision repair in mammalian cells
    R D Wood
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK
    Biochimie 81:39-44. 1999
    ..during nucleotide excision repair (NER) are the XPA protein, the heterotrimeric RPA protein, the 6 to 9-subunit TFIIH, the XPC-hHR23B complex, the XPG nuclease, and the ERCC1-XPF nuclease...
  23. ncbi Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Carcinogenesis 24:1671-6. 2003
    ..between the polymorphisms of two DNA repair genes, the nucleotide excision repair xeroderma pigmentosum group D (XPD) gene (codons 312 and 751) and the base excision repair X-ray repair cross-complementing group 1 (XRCC1) gene (..
  24. ncbi Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer
    Carsten Harms
    Center of Environmental Research and Technology, Laboratory of Bioanalytic, UFT, University of Bremen, Bremen, Germany
    Environ Mol Mutagen 44:74-82. 2004
    ..associations between any single variant genotype for several DNA-repair and chemical-metabolizing genes (XPD [or ERCC2], XRCC1, XRCC3, GSTM1, GSTT1, MPO, and mEH [or EPHX1]) and lung cancer...
  25. ncbi Association of XPD polymorphisms with prostate cancer in Taiwanese patients
    Da Tian Bau
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC
    Anticancer Res 27:2893-6. 2007
    The DNA repair gene XPD, an important caretaker of the overall genome stability, is thought to play a major role in the development of human malignancy...
  26. pmc XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck in a Korean Sample
    Yong Bae Ji
    Department of Otolaryngology Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Korea
    Clin Exp Otorhinolaryngol 3:42-7. 2010
    b>XPD is a major player in nucleotide excision repair, which is one of the basic pathways of DNA repair...
  27. pmc Correction of xeroderma pigmentosum complementation group D mutant cell phenotypes by chromosome and gene transfer: involvement of the human ERCC2 DNA repair gene
    W L Flejter
    Division of Human Genetics, University of Maryland, Baltimore 21201
    Proc Natl Acad Sci U S A 89:261-5. 1992
    ..a rearranged structure involving human chromosomes 16 and 19, including the excision repair cross-complementing 2 (ERCC2) gene from the previously described human DNA repair gene cluster at 19q13.2-q13.3...
  28. ncbi Polymorphism in the nuclear excision repair gene ERCC2/XPD: association between an exon 6-exon 10 haplotype and susceptibility to cutaneous basal cell carcinoma
    Tracy Lovatt
    Human Genomics Research Group, Institute for Science and Technology in Medicine, Keele University School of Medicine, University Hospital of North Staffordshire, Staffordshire, England, United Kingdom
    Hum Mutat 25:353-9. 2005
    ..2251A > C, dbSNP13181:g.A > C; designated A/C751) of the nucleotide excision repair gene, XPD (ERCC2; excision repair cross-complementing repair deficiency, complementation 2 [xeroderma pigmentosum D])...
  29. ncbi Selected DNA repair polymorphisms and gastric cancer in Poland
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 26:1354-9. 2005
    ..among the controls were consistent with those previously reported for the 5 polymorphisms studied: XRCC1-Arg399Gln, XPD-Lys751Gln, MGMT-Ile143Val, Leu84Phe, and XRCC3-Thr241Met...
  30. ncbi The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden
    Weimin Ye
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE 171 77, Sweden
    Carcinogenesis 27:1835-41. 2006
    ..a nationwide population-based case-control study, we examined associations of polymorphisms in the DNA repair genes XPD, XPC, XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia ..
  31. ncbi Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations
    Mayukh Banerjee
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Kolkata, India
    Carcinogenesis 28:672-6. 2007
    ..Arsenic exposure often leads to the development of hyperkeratosis, the precursor of arsenic-induced skin cancer. ERCC2 (excision repair cross-complementing rodent repair deficiency, complementation group 2) is a nucleotide excision ..
  32. pmc Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer
    Rui Gao
    Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Biol Ther 10:13-8. 2010
    ..152 healthy individuals were genotyped for five polymorphisms in DNA excision repair genes:ERCC1 N118N (500C>T), XPD K751Q (2282A>C), XRCC1 R194W (685C>T), XRCC1 R399Q (1301G>A) and PARP1 V762A(2446T>C)...
  33. doi Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis
    Zhen Feng
    Department of Thoracic Surgery, Provincial Hospital affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People s Republic of China
    Mol Biol Rep 39:57-69. 2012
    ..Overall, significantly elevated lung cancer risk was associated with ERCC2 312Asn allele(homozygous model: OR=1.20[1.05-1.36], P=0.006; recessive model: OR=1.20[1.06-1.35], P=0...
  34. doi XPD Lys751Gln polymorphism and esophageal cancer susceptibility: a meta-analysis of case-control studies
    Da peng Ding
    Institute of Genetic Engineering, Southern Medical University, Guangzhou, China
    Mol Biol Rep 39:2533-40. 2012
    The published data on the association between xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism and esophageal cancer (EC) remained controversial...
  35. ncbi Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy
    James M Allan
    Epidemiology and Genetics Unit, Department of Biology, University of York, York, United Kingdom, YO10 5YW
    Blood 104:3872-7. 2004
    The xeroderma pigmentosum group D (XPD) gene encodes a DNA helicase that functions in nucleotide excision repair of chemotherapy-induced DNA damage, the efficiency of which is predicted to be affected by a lysine to glutamine variant at ..
  36. ncbi ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population
    Guixiang Ji
    Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    Reprod Biomed Online 17:36-41. 2008
    The ERCC1 (excision repair cross complementation group 1) and ERCC2 (excision repair cross complementation group 2) genes are important in repairing DNA damage and genomic instability in germ cells, and are essential for normal ..
  37. ncbi Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution
    A L Gnatt
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Science 292:1876-82. 2001
    ..Protein-nucleic acid contacts help explain DNA and RNA strand separation, the specificity of RNA synthesis, "abortive cycling" during transcription initiation, and RNA and DNA translocation during transcription elongation...
  38. ncbi XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy
    Sarada Gurubhagavatula
    Department of Medicine, Massachusetts General Hospital, Boston, MA USA
    J Clin Oncol 22:2594-601. 2004
    ..Genetic polymorphisms of DNA repair genes are associated with differential DNA repair activity and may explain interindividual differences in overall survival after therapy with platinum agents for non-small-cell lung cancer (NSCLC)...
  39. doi XPD Lys(751)Gln and Asp (312)Asn polymorphisms and bladder cancer risk: a meta-analysis
    Chunxiang Li
    Laboratory of Medical Genetics, Harbin Medical University, Harbin, China
    Mol Biol Rep 37:301-9. 2010
    Studies on the polymorphisms of Xeroderma Pigmentosum Group D (XPD) have shown inconclusive trends in the risk of bladder cancer...
  40. ncbi Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:1408-15. 2005
    ..Polymorphisms in NER genes may influence DNA repair capacity and affect clinical outcome of bladder cancer treatment...
  41. ncbi Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005
    ..single-nucleotide polymorphisms in four DNA repair genes: MGMT (Leu84Phe and Ile143Val), XRCC1 (Arg399Gln), XPD (Lys751Gln), and XRCC3 (Thr241Met). All single-nucleotide polymorphisms were assayed in a single laboratory...
  42. ncbi Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
    R Drapkin
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854 5635
    Nature 368:769-72. 1994
    ..TFIIH is shown to complement three different cell extracts deficient in excision repair: XPB/ERCC3, XPC and XPD/ERCC2. The complementation of XPB and XPD is a consequence of ERCC3 and ERCC2 being integral subunits of TFIIH, whereas ..
  43. ncbi Human xeroderma pigmentosum group D gene encodes a DNA helicase
    P Sung
    Department of Biology, University of Rochester, New York 14627
    Nature 365:852-5. 1993
    ..The XPD gene was initially named ERCC2 (excision repair cross complementing) as it was cloned using human DNA to complement the ultraviolet sensitivity ..
  44. pmc Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
    J T Reardon
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Proc Natl Acad Sci U S A 93:6482-7. 1996
    ..Here we report the isolation of two TFIIH-related complexes: TFIIH* and ERCC2/CAK...
  45. pmc Human cyclin-dependent kinase-activating kinase exists in three distinct complexes
    R Drapkin
    Howard Hughes Medical Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 088854 5635, USA
    Proc Natl Acad Sci U S A 93:6488-93. 1996
    ..and characterization of three distinct CAK-containing complexes from HeLa nuclear extracts: CAK, a novel CAK-ERCC2 complex, and TFIIH...
  46. pmc Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene
    E M Taylor
    Medical Research Council Cell Mutation Unit, Sussex University, Falmer, Brighton BN1 9RR, United Kingdom
    Proc Natl Acad Sci U S A 94:8658-63. 1997
    ..Mutations in the XPD gene can result in three distinct clinical phenotypes, XP, trichothiodystrophy (TTD), and XP with Cockayne syndrome...
  47. ncbi XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis
    E M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 21:2219-23. 2000
    ..Variants of several DNA repair genes,including the nucleotide excision repair gene XPD, have been described recently...
  48. ncbi Trichothiodystrophy, a transcription syndrome
    E Bergmann
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Trends Genet 17:279-86. 2001
    ..These genes encode the helicase subunits of TFIIH, a DNA repair factor that is also required for transcription of class II genes...
  49. ncbi A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer
    D J Park
    Los Angeles County University of Southern California Medical Center, Department of Medicine, Los Angeles, California 90033, USA
    Cancer Res 61:8654-8. 2001
    The Xeroderma pigmentosum group D (XPD) protein is an essential participant in nucleotide excision repair and basal transcription...
  50. ncbi Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population
    Deyin Xing
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Int J Cancer 100:600-5. 2002
    ..the associations between genetic polymorphisms in the DNA repair genes XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) and risk of ESCC in an at-risk Chinese population...
  51. pmc A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer
    J Stoehlmacher
    Department of Hematology and Oncology, University of Hamburg, University Hospital, Hamburg 20247, Germany
    Br J Cancer 91:344-54. 2004
    ..Functional polymorphisms in DNA-repair genes XPD, ERCC1, XRCC1, XPA, and metabolising genes glutathione S-transferase GSTP1, GSTT1, GSTM1, and thymidylate synthase (..
  52. ncbi XPD polymorphism and risk of subsequent cancer in individuals with nonmelanoma skin cancer
    Abenaa M Brewster
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Epidemiol Biomarkers Prev 13:1271-5. 2004
    ..To test this hypothesis, a cohort study was conducted to examine the association between XPD Lys751Gln polymorphism and risk of a second primary cancer in individuals with NMSC.
  53. ncbi Polymorphisms in the DNA repair gene XPD and susceptibility to esophageal squamous cell carcinoma
    Hong Ping Yu
    Institute of Environmental Medicine, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China
    Cancer Genet Cytogenet 154:10-5. 2004
    Polymorphisms of the nucleotide excision repair gene XPD are candidates for influencing cancer susceptibility...
  54. ncbi ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population
    Christina Justenhoven
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, D 70376 Stuttgart, Germany
    Cancer Epidemiol Biomarkers Prev 13:2059-64. 2004
    ..The nucleotide excision repair enzyme encoded by the excision repair cross-complementing group 2 gene ERCC2 (formerly XPD) known to cause skin cancer by germ line mutations has multiple regulatory cellular functions, ..
  55. pmc Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan
    Chih Ching Yeh
    Institute of Environmental Health, National Taiwan University College of Public Health, Taipei 100, Taiwan
    BMC Cancer 5:12. 2005
    ..This study was designed to examine the polymorphisms associated with three DNA repair genes, namely: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, and investigate their role as susceptibility markers for colorectal cancer.
  56. ncbi Polymorphisms in XPD exons 10 and 23 and bladder cancer risk
    Matthew B Schabath
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:878-84. 2005
    The nucleotide excision repair gene, xeroderma pigmentosum complementation group D (XPD), has been hypothesized to have a role in cancer risk, but results from prior molecular epidemiologic studies and genotype-phenotype analyses are ..
  57. ncbi Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism
    Fabiola Festa
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Mutat Res 574:105-11. 2005
    ..634G/C, and -597G/A; IL-10-1082G/A and -592C/A; IL-1beta-511C/T; NBS1 exon 5 Glu185Gln; XPC exon 15 Lys939Gln; XPD exon 23 Lys751Gln; XRCC1 exon 10 Arg399Gln; XRCC3 exon 7 Thr241Met; cyclin D1 exon 4 G870A; MTHFR exon 4 Ala222Val ..
  58. pmc XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study
    Katja Metsola
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Breast Cancer Res 7:R987-97. 2005
    ..In this study, we evaluated if polymorphisms in DNA repair genes XRCC1 (Arg280His, Arg399Gln) and XPD (Lys751Gln) modify individual breast cancer risk, with emphasis on tobacco smoking.
  59. ncbi DNA repair gene polymorphisms and probability of p53 mutation in bladder cancer
    Mariana C Stern
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, USA
    Mol Carcinog 45:715-9. 2006
    We investigated if the presence of single nucleotide polymorphisms (SNPs) in the XRCC1, XRCC3, and XPD genes were associated with the type and frequency of p53 mutations in bladder cancer...
  60. ncbi Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Cancer Research Center of Nanjing Medical University, China
    Cancer Epidemiol Biomarkers Prev 15:1336-40. 2006
    The transcription factor IIH (TFIIH) helicases ERCC2/XPD and ERCC3/XPB are responsible for opening the DNA strand around the lesion site during nucleotide excision repair process...
  61. ncbi XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk
    Geoffrey Liu
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Carcinogenesis 28:1254-8. 2007
    ..We studied the role of genetic polymorphisms of two key DNA repair genes, xeroderma pigmentosum group D (XPD) (Asp312Asn and Lys751Gln) in the nucleotide excision repair (NER) pathway and X-ray repair cross-complementing ..
  62. pmc Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Med Sci 4:59-71. 2007
    ..genes, focusing on xeroderma pigmentosum group A (XPA), excision repair cross complementing group 1 (ERCC1), ERCC2/XPD, ERCC4/XPF and ERCC5/XPG...
  63. ncbi Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer
    Daniela F Giachino
    Department of Clinical and Biological Sciences, University of Torino, Turin, Italy
    Clin Cancer Res 13:2876-81. 2007
    XRCC1 and XPD play key roles in the repair of DNA lesions and adducts...
  64. ncbi XRCC1 codon 399 and ERCC2 codon 751 polymorphism, smoking, and drinking and risk of esophageal squamous cell carcinoma in a North Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Cancer Genet Cytogenet 175:91-7. 2007
    XRCC1 (X-ray cross-complementing group 1) codon 399 and ERCC2 (excision repair cross-complementing group 2) codon 751 polymorphisms were studied in esophageal squamous cell carcinoma (ESQCC) in a North Indian population...
  65. doi DNA repair gene XPD polymorphisms and cancer risk: a meta-analysis based on 56 case-control studies
    Fan Wang
    Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang Province, People s Republic of China
    Cancer Epidemiol Biomarkers Prev 17:507-17. 2008
    Genetic variations in the XPD gene may increase cancer susceptibility by affecting the capacity for DNA repair. Several studies have investigated this possibility; however, the conclusions remain controversial...
  66. doi Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer
    Eva Martinez-Balibrea
    Medical Oncology Service, Hospital Universitari Germans Trias i Pujol Institut Català d Oncologia, Badalona, Barcelona, Spain
    Eur J Cancer 44:1229-37. 2008
    We studied the role of TS (5'VNTR, 5'SNP and 3'UTR), XRCC1-399, XPD-751, ERCC1-118 and XRCC3-241 genetic polymorphisms in tailoring fluroropyrimidine/oxaliplatin treatment...
  67. pmc Strict sun protection results in minimal skin changes in a patient with xeroderma pigmentosum and a novel c.2009delG mutation in XPD (ERCC2)
    Steffen Emmert
    Department of Dermatology, Georg August University Goettingen, Goettingen, Germany
    Exp Dermatol 18:64-8. 2009
    ..8 J/m(2)), reduced nucleotide excision repair, reduced expression of XPD mRNA and an undetectable level of XPD protein...
  68. pmc Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy
    L Pare
    Department of Genetics, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona corrected Barcelona 08025, Spain
    Br J Cancer 99:1050-5. 2008
    ..We studied the usefulness of the excision repair cross-complementing 1 (ERCC1), xeroderma pigmentosum group D (XPD), XRCC1 and GSTP1 polymorphisms as predictors of clinical outcome in these patients...
  69. ncbi Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH
    F Coin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, B P 163, Illkirch, C U de Strasbourg, France
    Nat Genet 20:184-8. 1998
    ..of the evolutionarily conserved helicase XPD, which is one of the subunits of the transcription/repair factor TFIIH (refs 1,2)...
  70. ncbi A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy
    J E Cleaver
    UCSF Cancer Center and Department of Dermatology, University of California, San Francisco 94143 0808, USA
    Hum Mutat 14:9-22. 1999
    ..XP-E by this definition contains only those cell lines and patients that have mutations in the small subunit, DDB2, of a damage-specific DNA binding protein...
  71. ncbi An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study
    H Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 61:3321-5. 2001
    ..333, 0.281, 0.296, and 0.353, respectively). The case-control findings support the hypothesis that the XPC-PAT+ allele may contribute to the risk of developing SCCHN...
  72. ncbi XPD exon 10 and 23 polymorphisms and DNA repair in human skin in situ
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 14157 Huddinge, Sweden
    Carcinogenesis 22:1185-8. 2001
    ..studied with regard to the repair rate of UV-specific cyclobutane pyrimidine dimers in the skin were genotyped for XPD polymorphisms at codons 312 (exon 10 G-->A, Asp-->Asn) and 751 (exon 23 A-->C, Lys-->Gln)...
  73. ncbi XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects
    G Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126, Torino, ISI Foundation, Institute for Scientific Interchange, Villa Gualino, 10133, Torino, Italy
    Carcinogenesis 22:1437-45. 2001
    ..and three genetic polymorphisms in different repair genes: XRCC1-Arg399Gln (exon 10), XRCC3-Thr241Met (exon 7) and XPD-Lys751Gln (exon 23)...
  74. ncbi Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes
    Yawei Qiao
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 1515 Holcombe Boulevard, TX 77030, USA
    Carcinogenesis 23:295-9. 2002
    ..benzo[a]pyrene diol epoxide-induced DNA damage measured by a host-cell reactivation assay was modulated by two XPD/ERCC2 polymorphisms in lung cancer...
  75. ncbi XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis and the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:1004-11. 2002
    ..DNA damage from such adducts is mainly repaired by the nucleotide excision repair pathway, in which the XPD protein functions in opening the DNA helix...
  76. ncbi Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population
    Deyin Xing
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Lung Cancer 38:123-9. 2002
    ..is associated with cancer risk and that the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementary group D (XPD) gene may influence DNA repair capacity...
  77. ncbi ERCC2/XPD gene polymorphisms and cancer risk
    Simone Benhamou
    EMI 00 06, INSERM Universite d Evry, 91034 Evry
    Mutagenesis 17:463-9. 2002
    ..Several SNPs have been described in the ERCC2/XPD gene, but three in particular have been studied: the C-->A silent polymorphism (Arg156Arg) in exon 6, the G-..
  78. ncbi Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3: linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients
    Jiaoyang Yin
    Institute of Human Genetics, University of Aarhus, Aarhus C DK 8000, Denmark
    Biochem Genet 41:27-37. 2003
    ..17-124; p(chi2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06). This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al...
  79. ncbi Sequence variations in the DNA repair gene XPD and risk of lung cancer in a Chinese population
    Gang Liang
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China
    Int J Cancer 105:669-73. 2003
    ..The Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementary group D (XPD) gene may alter DNA repair capacity...
  80. ncbi ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review
    Simone Benhamou
    Institut National de la Santé et de la Recherche Médicale Evry University, 91034 Evry, France
    Am J Epidemiol 161:1-14. 2005
    The xeroderma pigmentosum group D (XPD) protein is a well-characterized DNA helicase necessary for the nucleotide excision repair of bulky DNA lesions, such as those induced by cigarette smoking...
  81. ncbi Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract
    Shama Buch
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
    Mol Carcinog 42:222-8. 2005
    ..The XPD protein is an important component of the TFIIH transcription factor complex...
  82. ncbi Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): relationship to breast cancer risk and familial predisposition to breast cancer
    A M Brewster
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Breast Cancer Res Treat 95:73-80. 2006
    ..This population based case-control study examined the association between polymorphisms in XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp) genes, and breast cancer...
  83. ncbi Genetic variation in the nucleotide excision repair pathway and bladder cancer risk
    Montserrat Garcia-Closas
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:536-42. 2006
    ..bladder cancer risk by analyzing 22 single nucleotide polymorphisms (SNP) in seven NER genes (XPC, RAD23B, ERCC1, ERCC2, ERCC4, ERCC5, and ERCC6)...
  84. ncbi Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer
    Sambasivarao Damaraju
    Cross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 12:2545-54. 2006
    ....
  85. ncbi Xeroderma pigmentosum group D haplotype predicts for response, survival, and toxicity after platinum-based chemotherapy in advanced nonsmall cell lung cancer
    Richard Booton
    Christie Hospital National Health Service Trust, Manchester, United Kingdom
    Cancer 106:2421-7. 2006
    ..Polymorphisms within the Xeroderma pigmentosum Group D protein (XPD), a member of the NER pathway, are associated with alterations in enzyme activity and may change sensitivity to ..
  86. ncbi [XRCC1 and XPD genetic polymorphisms predict clinical responses to platinum-based chemotherapy in advanced non-small cell lung cancer]
    Peng Yuan
    Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Zhonghua Zhong Liu Za Zhi 28:196-9. 2006
    ..The purpose of this study was to examine the association between polymorphisms in XRCC1 and XPD, which are involved in DNA repair, and clinical responses to platinum-based chemotherapy in advanced non-small cell ..
  87. ncbi Polymorphism of the DNA repair gene ERCC2 Lys751Gln and risk of lung cancer in a northeastern Chinese population
    Jiaoyang Yin
    Department of Medical Genetics, Shenyang Medical College, No 146, N Huanghe St, Yuhong District, Shenyang 110034, Liaoning Province, PR China
    Cancer Genet Cytogenet 169:27-32. 2006
    The ERCC2 gene (excision repair cross-complementing rodent repair deficiency, complementation group 2 [xeroderma pigmentosum D]) (previously XPD), encoding a DNA repair protein, is involved in nucleotide excision repair and basal ..
  88. ncbi Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials
    Nataliya Kuptsova
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Blood 109:3936-44. 2007
    ..We evaluated the role of polymorphisms in DNA repair genes APE1, XRCC1, ERCC1, XPD, and XRCC3 in predicting therapeutic outcomes of older adults with acute myeloid leukemia (AML) from 2 Southwest ..
  89. ncbi DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma
    Joanne E Povey
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Carcinogenesis 28:1087-93. 2007
    ..59, P = 0.008; XPF OR 1.69, P = 0.003]. Although an XPD haplotype was associated with melanoma, it did not contain the variant 751 Gln allele, which has been associated ..
  90. ncbi Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer
    Annamaria Ruzzo
    Institute of Biochemistry G Fornaini, University of Urbino, Urbino, Italy
    Clin Chem Lab Med 45:822-8. 2007
    ..We carried out a case-control study to evaluate whether polymorphisms of DNA repair and glutathione S-transferase (GST) genes modulate the risk of developing diffuse gastric cancer...
  91. ncbi Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India
    Leelakumari Sreeja
    Division of Cancer Research, Regional Cancer Centre, Trivandrum, Kerala 695011, India
    J Cancer Res Clin Oncol 134:645-52. 2008
    ..Two of the genetic polymorphisms, XRCC1Arg399Gln and XPD Lys751Gln have been extensively studied in the association with lung cancer risk, although published studies have ..
  92. pmc ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study
    Ming Yii Huang
    Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan
    BMC Cancer 8:50. 2008
    ..To our knowledge, this study discusses, for the first time, early cancer relapse and its indication by multiple genes...
  93. ncbi Relationship between polymorphisms of nucleotide excision repair genes and oral cancer risk in Taiwan: evidence for modification of smoking habit
    Da Tian Bau
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC
    Chin J Physiol 50:294-300. 2007
    ..Both XPA and XPD encode proteins that are part of the nucleotide excision repair (NER) pathway...
  94. pmc Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis
    Hui Zhao
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1560-6. 2008
    ..group 1 (ERCC1) and excision repair cross-complementing complementation group 2/xeroderma pigmentosum D (ERCC2/XPD) participate in the nucleotide excision repair (NER) pathway that removes BPDE-DNA adducts; however, few ..
  95. doi DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia
    Bahadir Batar
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Leuk Res 33:759-63. 2009
    ..aimed to determine the four polymorphisms in two DNA repair genes, xeroderma pigmentosum complementation group D (XPD) and X-ray repair cross-complementing group 1 (XRCC1), in a sample of Turkish patients with childhood acute ..
  96. doi Very low prevalence of XPD K751Q polymorphism and its association with XPD expression and outcomes of FOLFOX-4 treatment in Asian patients with colorectal carcinoma
    Jiun I Lai
    National Yang Ming University School of Medicine, Taipei, Taiwan
    Cancer Sci 100:1261-6. 2009
    Xeroderma pigmentosum group D (XPD) participates in DNA unwinding during nucleotide excision repair, which may alter the efficacy of platinum-based chemotherapy...
  97. doi DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia
    Christina Ganster
    Department of Medical Genetics, Medical University of Vienna, Vienna, Austria
    Genes Chromosomes Cancer 48:760-7. 2009
    ..However, differences were observed in the distribution of rs13181 in ERCC2 between all CLL patients and controls...
  98. ncbi Common polymorphisms in the XPD and hOGG1 genes are not associated with the risk of colorectal cancer in a Polish population
    Tomasz Sliwinski
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Tohoku J Exp Med 218:185-91. 2009
    ..Xeroderma pigmentosum group D (XPD) protein and human homolog of the 8-oxoguanine glycosylase 1 (hOGG1) are involved in nucleotide excision repair and ..
  99. pmc Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Res 69:6857-64. 2009
    ..We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95% confidence interval (95% CI), 1.01-1.19; P = 0...
  100. doi Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial
    Michael S Braun
    Oncology and Clinical Research and Pathology and Tumour Biology Sections, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    J Clin Oncol 27:5519-28. 2009
    ..Predicting efficacy and toxicity could potentially allow individualization of cancer therapy. We investigated putative pharmacogenetic markers of chemotherapy toxicity in a large randomized trial...
  101. pmc Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study
    Ilir Agalliu
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Cancer Causes Control 21:289-300. 2010
    ..Alterations of this pathway have been reported in many cancers. An increase in oxidative DNA damage or decrease in DNA repair capacity with aging or due to germline genetic variation may affect prostate cancer risk...

Research Grants73

  1. John A Tainer; Fiscal Year: 2015
    ..In humans, XPB and XPD helicases are part of the ten subunit TFIIH transcription/repair complex, but disease-causing mutations cluster in XPB and particularly XPD rather than in the ..
  2. The Meningioma Consortium: Genome-Wide Association Study
    Elizabeth B Claus; Fiscal Year: 2013
    ..previous associations from the Tineas Capitas study of meningioma risk with variants in DNA repair genes (KRAS2, ERCC2, CCND1)...
  3. WORKER GENETIC SUSCEPTIBILITY TO MUTAGENIC RISK
    Paul W Brandt-Rauf; Fiscal Year: 2013
    ..etheno-DNA adducts that can be removed by base excision repair (via XRCC1) or nucleotide excision repair (via XPD), or, if not repaired, result in specific mutations in cancer-related genes (the ras oncogene and the TP53 tumor ..
  4. Bennett Van Houten; Fiscal Year: 2016
    ..by human damage recognition proteins, XPC-HR23B, XPA, RPA, and UV-DDB;and 3) to examine the dynamics of human XPD (ERCC2), and XPB (ERCC3) helicase proteins on DNA...
  5. DNA Repair, Skin Cancer and Overall Cancer Risk
    Anthony Alberg; Fiscal Year: 2009
    ..in the cohort indicating an increased risk of subsequent cancer in persons with a history of NMSC who had ERCC2./XPD Lys751GIn Lys/GIn or Gin/Gin genotypes...
  6. PAUL KHAVARI; Fiscal Year: 2016
    ..repair (BER) pathway (MBD4, TDG, and AID/Apobec2) and the nucleotide excision repair (NER) pathway (XPA, XPG, ERCC2, TAF12). Gadd45 proteins interact with both BER and NER mechanisms to enable DNA demethylation...
  7. Alan M Weiner; Fiscal Year: 2014
    ..CS has long been thought to be a disease of DNA repair because all 5 genes that can cause CS (CSA, CSB, XPB, XPD, and XPG) are essential for transcription-coupled nucleotide excision repair (TC-NER)...
  8. SUSAN THOMAS LOVETT; Fiscal Year: 2016
    ..The first aim of this study seeks to clarify how the YoaA protein, a member of the XPD/FANCJ family of helicases mutated in human disease syndromes, participates in replication gap repair by studies of ..
  9. CELLULAR AND MOLECULAR RESPONSE TO DNA REPAIR DEFICIENCY
    Renee Reijo Pera; Fiscal Year: 2000
    ..The XRCC1-complemented CHO cell line, EM9, is hypersensitive to many mutagenic agents, and demonstrates a 10-fold increase in baseline levels of sister ..
  10. The role of DNA repair in retroviral infection
    KRISTINE E contact YODER; Fiscal Year: 2010
    ..to define the components and mechanism of TFIIH mediated retroviral cDNA degradation pathway, and 2...
  11. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  12. Molecular Genetics of Colon Cancer in Blacks and Whites
    Jennifer Hu; Fiscal Year: 2005
    ..XRCC1 and APE), a gene in double-strand break/recombination repair (XRCC3), and a nucleotide excision repair gene (XPD)...
  13. Molecular Analysis of Esophageal Cancer Survival
    Matthew Kulke; Fiscal Year: 2007
    ..survival and the presence of specific genetic polymorphisms (GSTP1, GSTM1, GSTT1, CYP1A1, CYP3A5, p53, XRCC1 and ERCC2) in patients with esophageal cancer...
  14. MOUSE MODELS OF DNA REPAIR DEFECTIVE HUMAN DISEASES
    Errol Friedberg; Fiscal Year: 2000
    ..Additionally they are subunits of the RNA polymerase II transcription factor IIH (TFIIH) and hence are also indispensable for transcription initiation...
  15. MECHANISM & CONTROL OF HUMAN NUCLEOTIDE EXCISION REPAIR
    Zhen Qiang Pan; Fiscal Year: 2001
    ..Recently, the applicant has isolated two novel human TFIIH-related complexes: TFIIH* and ERCC2/CAK. TFIIH* consists of a subset of the TFIIH complex proteins including ERCC3, p62, p44, p41, and p34...
  16. GENETIC ANALYSIS OF NUCLEOTIDE EXCISION REPAIR
    LAWRENCE THOMPSON; Fiscal Year: 2002
    ..ERCC2 is a component of the TFIIH transcription-repair complex, and the unwinding activity of ERCC2 is required for nucleotide excision repair (NER) ..
  17. MECHANISM OF INITIATION BY RNA POLYMERASE II
    JAY GRALLA; Fiscal Year: 2007
    This proposal is aimed at learning the roles of the XPB and XPD subunits of the multi-protein factor TFIIH. TFIIH is essential for transcription of RNA, repair of DNA and control of cellular mitosis...
  18. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    ..common germline variants of the GST and NAT metabolizing enzymes, or of DNA repair enzymes (XRCC1, APE, HOGG1, XPA, XPD, XPF, and others), modify the prevalence of LOH or p53 mutations associated with smoking...
  19. Prenatal Exposures & Procarcinogenic Mutations
    Manuela Orjuela; Fiscal Year: 2007
    ..Infant DNA repair capacity (XPD/XRCC1) probably also plays a role in the persistence of chromosomal damage...
  20. DETECTION & REVERSAL OF OVARIAN CANCER DRUG RESISTANCE
    Robert Ozols; Fiscal Year: 1992
    ..and expression of mRNA for enzymes which participate in DNA repair (DNA polymerases alpha and beta, ERCC1 and ERCC2)...
  21. Seth Blackshaw; Fiscal Year: 2016
    ..We will test whether the TFIIH-associated proteins ERCC2 and CDK7 might mediate this effect by blocking PIAS3-dependent SUMOylation of NR2E3 when ..
  22. HUMAN XRCC1 PROTEIN IN DNA REPAIR AND RECOMBINATION
    MICHAEL THELEN; Fiscal Year: 2001
    ..The XRCC1 gene was cloned based on its ability to correct the repair defect of the hamster cell mutant EM9. XRCC1 protein was later shown to interact with several BER participants, namely DNA Ligase III, DNA Polymerase ..
  23. MAP KINASES AND NUCLEOTIDE EXCISION REPAIR
    PAUL VICHI; Fiscal Year: 2000
    ..Studies focus on c-Jun-NH2-terminal kinase (JNK)-mediated activation of the transcription/repair factor TFIIH. NER is the predominant mechanism in eukaryotic cells for repair of ultraviolet (UV) or cis-platinum-induced DNA ..
  24. Genomic Instability in Melanoma Pathogenesis
    Robin Edwards; Fiscal Year: 2006
    ..Next, three NER genes - XPA, XPC, and XPD - will be analyzed by Western blot and direct sequencing...
  25. The Aux/IAA and ARF Gene Families in Auxin Signaling
    Athanasios Theologis; Fiscal Year: 2005
    ..AGE1 is a homolog of the yeast RAD3 and human XPD/ERCC2 protein, which is a component of the TFIIH transcription factor that participates in nucleotide excision repair (NER) and basal transcription...
  26. CLUE STUDIES--EVALUATING BIOMARKERS OF CARCINOGENESIS
    Kathy Helzlsouer; Fiscal Year: 2004
    ..a potent8ial marker for the early detection of aggressive forms of breast cancer; genetic polymorphisms in the XPD gene, a potential marker of susceptibility to the development of a second primary cancer among individuals with non-..
  27. DNA repair, genetic variation and skin cancer
    David Hunter; Fiscal Year: 2003
    ..We hypothesize that candidate polymorphisms and haplotypes in three important DNA repair genes (XPD in nucleotide excision repair; XRCC1 in base excision repair; XRCC3 in homologous recombination repair) are ..
  28. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003
    ..P-450 (CYP) CYP2C9, CYP2C19, CYP3A4, thiopurine methyltransferase, methylguanine DNA methyltransferase, ERCC1, XPD, XRCC1, XRCC2, XRCC3, XRCC4 and XRCC5...
  29. The roles of XPF/ERCC1 complex in DNA repair
    Tadayoshi Bessho; Fiscal Year: 2007
    ..The NER factors, XPA, RPA, XPC/HHR23B, TFIIH (contains XPB and XPD) and XPG are supposed to generate a specific unwound structure for the XPF/ERCC1 complex to ..
  30. Genetic Polymorphisms in Myeloma
    Brian Van Ness; Fiscal Year: 2003
    ..P450, myeloperoxidase, glutathione S-transferases (M,T,P), multi-drug resistance 1); DNA repair (XRCCC1, ERCC2); and, myeloma related growth factors (lL-6, IL-1b, IL-1RA, IL-10, TNa, Lta, TGFb)...
  31. GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT
    Sandra Hoffman; Fiscal Year: 2003
    ..GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, EH); and 3) control DNA repair processes (XRCC1, XRCC3, XPD)...
  32. DNA Repair and Bladder Cancer
    Angeline Andrew; Fiscal Year: 2004
    ..project will be to 1) test the hypothesis that genetic variants in the nucleotide excision repair pathway genes (XPD, XPC, XPA, and ERCC1), are associated with increased risk of bladder cancer, and 2) determine whether environmental ..
  33. Repair & Prevention of DNA Damage & Breast Cancer Risk
    Roy Shore; Fiscal Year: 2005
    ..help prevent DNA damage (GSTP1, MnSOD, catalase) and 9 genes in the DNA nucleotide-excision repair pathway (XPC, XPD, XPF, XPG) or base-excision repair pathway (XRCC1, APE1, LIG3, POLD1, hOGG1) will be studied in relation to breast ..
  34. DNA Damage and Neurodegeneration in Cockayne Syndrome
    James Cleaver; Fiscal Year: 2009
    ..Successful conclusion of these studies will expand our knowledge of mechanisms of neurodegeneration and lay groundwork for development of therapeutic approaches for CS patients. ..
  35. The XP Variant: A Human Mutator Gene for UV Damage
    James Cleaver; Fiscal Year: 2005
    ..We will express hRad3O on the keratin 14 promoter for over-expression in the skin, and make targeted knockout of mRad3O in vivo to identify roles for hRad3O in promoting and preventing carcinogenesis. ..
  36. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  37. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2008
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  38. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2007
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  39. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2004
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  40. Nucleotide Excision Repair Gene Variants and Skin Cancer
    Jiali Han; Fiscal Year: 2005
    ..abstract_text> ..
  41. CLINICAL AND EPIDEMIOLOGIC CENTER FOR BIOMARKERS OF UPPE
    Margaret Spitz; Fiscal Year: 2004
    ..The team of investigators is multi-disciplinary and will be able to respond in a timely and flexible manner to network directives, and to enhance and augment the network's research capabilities. ..
  42. Pharmacogenetics advanced colorectal cancer
    Howard McLeod; Fiscal Year: 2004
    ..These aims provide a comprehensive framework for our strategy to provide the first prospective information on the integration of pharmacogenetic information into the selection of therapy for advanced colorectal cancer. ..
  43. DNA REPAIR AND CANCER PRONE HEREDITARY HUMAN DISEASE
    Errol Friedberg; Fiscal Year: 2002
    ....
  44. DNA REPAIR GENE POLYMORPHISMS AND BREAST CANCER RISK
    TIMOTHY JORGENSEN; Fiscal Year: 2003
    ..an important role in protecting against breast carcinogenesis, and that polymorphisms in DNA repair genes, such as XPD, may influence breast cancer susceptibility in general, and possibly ionizing radiation-induced carcinogenesis, in ..
  45. H.pylori, genes and esophageal adenocarcinoma
    Geoffrey Liu; Fiscal Year: 2005
    ..abstract_text> ..
  46. Prospective Study of DNA Repair Gene Variants in Breast Cancer
    Jiali Han; Fiscal Year: 2009
    ..This innovative work is essential to advance this field, and it has substantial potential for application to other areas of cancer susceptibility. ..
  47. Early Determinants of Breast Cancer Risk
    Mary Beth Terry; Fiscal Year: 2006
    ..abstract_text> ..
  48. Cognitive Consequences of Endocrine Dysfunction in IDU
    Adrian Dobs; Fiscal Year: 2007
    ..We will obtain a better understanding of the relationship between drug use and cognition, and also expand our understanding of the effects of sex steroids on cognitive performance, in an under-studied population. ..
  49. Adenocarcinoma of the Lung: role of NNK susceptibility
    Margaret Spitz; Fiscal Year: 2008
    ..This research is also applicable to other sites since tobacco-specific nitrosamines are causative agents in esophagus, pancreas and oral cavity cancers, and are the most prevalent carcinogen in snuff products. [unreadable] [unreadable]..
  50. Early Determinants of Mammographic Density
    Mary Beth Terry; Fiscal Year: 2009
    ..abstract_text> ..
  51. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2009
    ..abstract_text> ..
  52. PHASE I TRIALS OF ANTICANCER AGENTS
    SUE ECKHARDT; Fiscal Year: 2007
    ..abstract_text> ..
  53. PROSTATE CANCER IN MEXICANS AMERICANS & AFRICAN AMERICAN
    Sara Strom; Fiscal Year: 2003
    ..Understanding how genetic predisposition and exogenous exposures interact to determine prostate cancer susceptibility will allow the development of more effective ethnic-specific prevention strategies. ..
  54. Telomere dysfunction, oxidative damage and breast cancer risk
    Jing Shen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. DNA REPAIR AND ITS RELATIONSHIP TO CARCINOGENESIS
    Errol Friedberg; Fiscal Year: 2001
    ..Recent evidence suggests that the Rad proteins required for NER as well as the subunits of TFIIH are preassembled into a large NER machine that has been designated as the nucleotide excision repairosome...
  56. Overcoming Age-Dependent Barriers to Early Phase Trials
    S Eckhardt; Fiscal Year: 2004
    ....
  57. Genetic Variants in Pigmentation Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying high-risk individuals for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  58. The Social Value of Becoming a Parent
    Douglas Wolf; Fiscal Year: 2006
    ....
  59. CASE CONTROL STUDY OF RISK FACTORS FOR WILMS TUMOR
    Andrew Olshan; Fiscal Year: 2002
    ..This study will provide important new advances in our understanding of Wilms tumor given the study size, quality of exposure assessment, and incorporation of clinical and biological markers of etiologic heterogeneity. ..
  60. MOUSE MODELS OF DNA REPAIR - DEFECTIVE HUMAN DISEASES
    Errol Friedberg; Fiscal Year: 2011
    ..abstract_text> ..
  61. Gene Environment Interaction in Head and Neck Cancer
    Andrew Olshan; Fiscal Year: 2005
    ..The proposed study should contribute knowledge on gene-environment interactions for cancer of the head and neck, but also for other tobacco- and alcohol-related cancers and possibly cancers of unknown etiology. ..
  62. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2010
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  63. Coordination of the late steps of human nucleotide excision repair
    ORLANDO D SCHARER; Fiscal Year: 2010
    ..Since NER proteins also contribute to the resistance of tumor cells to anti-cancer agents our investigations may also provide new targets for anti- tumor therapy. ..
  64. Health and QOL among Long-Term Lung Cancer Survivors
    Ping Yang; Fiscal Year: 2010
    ....
  65. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2007
    ..3) To elucidate the role that specific polymorphisms in DNA repair capacity genes (XRCC1, XPD and XRCC3) and cell cycle control (p53 gene) play in the modulation of HD outcome...
  66. Molecular Epidemiology of Esophageal Cancer Prognosis
    Geoffrey Liu; Fiscal Year: 2008
    ..Furthermore, the proposed studies address directly a prioritized research area identified by the NCI Stomach and Esophageal Cancers Progress Review Group (Year 2002). ..
  67. Genetic Predictors for DNA Repair Phenotype in CMM
    Qingyi Wei; Fiscal Year: 2008
    ..e., XPA, XPB/excision repair cross-complementing group 3 (ERCC3), XPC, XPD/ERCC2, XPE/damaged DNA-binding protein (DDB1), XPF/ERCC4 and XPG/ERCC5)code for core proteins involved in the nucleotide ..
  68. Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer Recurrence
    Erich Sturgis; Fiscal Year: 2008
    ..abstract_text> ..
  69. Genetic Variants in Immunological Mediator Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying individuals at high-risk for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  70. Uptake and Mutagenicity of Moderately Soluble Hexavalent Chromium
    DIANE STEARNS; Fiscal Year: 2008
    ..Understanding the mode of action of these chromates will provide a foundation for human risk assessment. [unreadable] [unreadable] [unreadable]..
  71. Biobehavioral-Smoking Profiles in Mexican-American Youth
    Margaret Spitz; Fiscal Year: 2008
    ..These findings will enable us to develop culturally and age-appropriate school- and community-based smoking cessation interventions. ..
  72. Comprehensive NAU/AZCC Cancer Research Partnership
    DIANE STEARNS; Fiscal Year: 2008
    ..Research activities include basic science, cancer education, and community outreach components. We propose 6 pilot projects, 4 full projects, and recruitment of 2 new faculty over the project lifetime. ..
  73. End-of-Life Trajectories: A Prospective Model
    Douglas Wolf; Fiscal Year: 2009
    ..Finally, Active Life Expectancy-the number of years people can expect to live in an "active" or healthy state-has become a widely-accepted index of public health, and our model will produce improved estimates of this index. ..