Gene Symbol: ERC2
Description: ELKS/RAB6-interacting/CAST family member 2
Alias: CAST, CAST1, ELKSL, SPBC110, Spc110, ERC protein 2, CAZ-associated structural protein, cytomatrix protein p110
Species: human

Top Publications

  1. ncbi Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton
    Rene E Harrison
    Cell Biology Programme, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 1X8, Canada
    J Cell Sci 117:2151-7. 2004
  2. pmc Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1
    Toshihisa Ohtsuka
    KAN Research Institute Inc, Kyoto 600 8815, Japan
    J Cell Biol 158:577-90. 2002
  3. pmc A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
    Yun Wang
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 99:14464-9. 2002
  4. pmc Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release
    Etsuko Takao-Rikitsu
    KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
    J Cell Biol 164:301-11. 2004
  5. ncbi [The impact of cancer on the healing status of patients]
    E Cortesi
    Cattedra di Oncologia Medica, Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Roma
    Tumori 84:S20-3. 1998
  6. ncbi What, if anything, is controversial about calcium antagonists?
    F H Messerli
    Department of Internal Medicine, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 9:177S-181S. 1996
  7. ncbi [Specific treatment of the acute cerebral infarct. Present and future]
    J J Muñoz-Torrero
    Servicio de Neurologia, Unidad de Ictus, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 31:959-82. 2000
  8. ncbi Iliac crest bone grafting and Herbert screw fixation of nonunions of the scaphoid with avascular proximal poles
    R R Robbins
    Department of Orthopaedics, University of Texas Southwestern Medical Center, Dallas, USA
    J Hand Surg Am 20:818-31. 1995
  9. ncbi Identification of an Spc110p-related protein in vertebrates
    A M Tassin
    Institut Curie, Section Recherche, UMR 144 du CNRS, Paris, France
    J Cell Sci 110:2533-45. 1997
  10. ncbi Transoral anterior decompression and fusion of chronic irreducible atlantoaxial dislocation with spinal cord compression
    B Subin
    J Vernon Luck, SR, MD Orthopaedic Research Center, Orthopaedic Hospital of Los Angeles, USA
    Spine (Phila Pa 1976) 20:1233-40. 1995

Detail Information

Publications249 found, 100 shown here

  1. ncbi Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton
    Rene E Harrison
    Cell Biology Programme, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 1X8, Canada
    J Cell Sci 117:2151-7. 2004
  2. pmc Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1
    Toshihisa Ohtsuka
    KAN Research Institute Inc, Kyoto 600 8815, Japan
    J Cell Biol 158:577-90. 2002
    ..We have identified here a novel CAZ protein of approximately 120 kD from rat brain and named it CAST (CAZ-associated structural protein)...
  3. pmc A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
    Yun Wang
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 99:14464-9. 2002
    ..ERC1a variant that does not bind to RIMs and a shorter ERC1b variant that binds to RIMs, whereas the C terminus of ERC2 is synthesized only in a single RIM-binding variant...
  4. pmc Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release
    Etsuko Takao-Rikitsu
    KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
    J Cell Biol 164:301-11. 2004
    We have recently isolated a novel cytomatrix at the active zone (CAZ)-associated protein, CAST, and found it directly binds another CAZ protein RIM1 and indirectly binds Munc13-1 through RIM1; RIM1 and Munc13-1 directly bind to each other ..
  5. ncbi [The impact of cancer on the healing status of patients]
    E Cortesi
    Cattedra di Oncologia Medica, Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Roma
    Tumori 84:S20-3. 1998
    ..on the contents of quality of life can be derived only studying people suffering the specific disease and cast a doubt on the available QL instruments currently used...
  6. ncbi What, if anything, is controversial about calcium antagonists?
    F H Messerli
    Department of Internal Medicine, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 9:177S-181S. 1996 the post myocardial infarction patient, would paradoxically increase the rate of heart attack and mortality have cast doubts on the safety and efficacy of this drug class...
  7. ncbi [Specific treatment of the acute cerebral infarct. Present and future]
    J J Muñoz-Torrero
    Servicio de Neurologia, Unidad de Ictus, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 31:959-82. 2000
    ..Another European study is still underway (ESTAT). With regard to antiaggregants, IST and CAST were done using Aspirin, showing a drop in early recurrences and increase in recoveries, so that aspirin has been ..
  8. ncbi Iliac crest bone grafting and Herbert screw fixation of nonunions of the scaphoid with avascular proximal poles
    R R Robbins
    Department of Orthopaedics, University of Texas Southwestern Medical Center, Dallas, USA
    J Hand Surg Am 20:818-31. 1995
    ..All patients were immobilized after operation in a short-arm thumb spica cast for 3 months and were then allowed active range of motion of their wrists...
  9. ncbi Identification of an Spc110p-related protein in vertebrates
    A M Tassin
    Institut Curie, Section Recherche, UMR 144 du CNRS, Paris, France
    J Cell Sci 110:2533-45. 1997
    ..Altogether, these results suggest the existence of an yeast Spc110-related protein in vertebrate centrosomes which is involved in microtubule nucleation.
  10. ncbi Transoral anterior decompression and fusion of chronic irreducible atlantoaxial dislocation with spinal cord compression
    B Subin
    J Vernon Luck, SR, MD Orthopaedic Research Center, Orthopaedic Hospital of Los Angeles, USA
    Spine (Phila Pa 1976) 20:1233-40. 1995
    ..Postoperative treatment included skull-cervical biaxial traction, tracheostomy care, nasal feeding, and Minerva cast. RESULTS...
  11. ncbi Quality control by portal film analysis in radiotherapy for prostate cancer: a comparison between two different institutions and treatment techniques
    C Italia
    Department of Radiation Oncology, Casa di Cura S. Pio X, Milan, Italy
    Tumori 84:640-8. 1998
    ..In Institute A, patients were treated in a prone position, utilizing an individualized immobilization cast (either an alpha cradle or a heat and vacuum-formed cellulose acetate cast) with an open table top and individual ..
  12. pmc Effects of analogues of adenine nucleotides on increases in intracellular calcium mediated by P2T-purinoceptors on human blood platelets
    D A Hall
    Receptors and Cellular Regulation Research Group, School of Biological Sciences, University of Surrey, Guildford
    Br J Pharmacol 108:728-33. 1993
    ..These findings cast further doubt on the use of the affinity reagent 5'-fluorosulphonylbenzoyladenosine (FSBA) as an antagonist and ..
  13. ncbi Protein adsorption onto poly(ether urethane ureas) containing Methacrol 2138F: a surface-active amphiphilic additive
    M R Brunstedt
    Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio 44106
    J Biomed Mater Res 27:255-67. 1993
    ..formulations loaded with Methacrol 2138F were more hydrophobic than was the air side of base PEUUs when films were cast from dimethylacetamide...
  14. ncbi [Management of patients with risk of sudden death. The amiodarone example]
    J Djian
    Sanofi Winthrop, Gentilly
    Arch Mal Coeur Vaiss 87:67-74. 1994
    ..Since the publication of the CAST study, the arrhythmia hypothesis, according to which the suppression of asymptomatic arrhythmias would decrease ..
  15. ncbi The histopathology of kidney changes in rats and monkeys following intravenous administration of massive doses of FCE 26184, human basic fibroblast growth factor
    G Mazue
    Farmitalia Carlo Erba, R and D Toxicology Department, Nerviano Milano, Italy
    Toxicol Pathol 21:490-501. 1993 the kidneys that included enlargement, vacuolation, and karyomegaly of podocytes in glomeruli, dilatation and cast formation in tubules, thickening of the media in the lobular arteries, and hyperplasia of the epithelium of the ..
  16. ncbi Can cast immobilization successfully treat scapholunate dissociation associated with distal radius fractures?
    J B Tang
    Hand Surgery Center, Nantong Medical College, Jiangsu, China
    J Hand Surg Am 21:583-90. 1996 indicates that scapholunate dissociation with concomitant fractures of the distal radius cannot be cured by cast immobilization of the fracture...
  17. pmc A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated
    J V Kilmartin
    MRC Laboratory of Molecular Biology, Cambridge, England
    J Cell Biol 123:1175-84. 1993
    ..against the 110-kD component of the yeast spindle pole body (SPB) were used to clone the corresponding gene SPC110. SPC110 is identical to NUF1 (Mirzayan, C., C. S. Copeland, and M. Synder. 1992. J. Cell Biol. 116:1319-1332)...
  18. ncbi Enzyme-based biosensor as a selective detection unit in column liquid chromatography
    G Marko-Varga
    Department of Analytical Chemistry, University of Lund, Sweden
    J Chromatogr A 660:153-67. 1994
    ..Different membranes were cast or electropolymerized directly on the surface of the electrode to increase the long-term stability of the biosensor...
  19. ncbi The wear of ultra-high molecular weight polyethylene sliding on metallic and ceramic counterfaces representative of current femoral surfaces in joint replacement
    J G Lancaster
    Department of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 211:17-24. 1997
    ..The biomaterials investigated as the counterface material included stainless steel, cast cobalt chrome (CoCr), CoCr (ASTM F799), alumina ceramic and zirconia ceramic...
  20. ncbi Reversed-phase electrochromatography of amino acids and peptides using porous polymer monoliths
    R Shediac
    Chemical and Radiation Detection Laboratories, Sandia National Laboratories, Livermore, CA 94551-0969, USA
    J Chromatogr A 925:251-63. 2001
    ..The rigid monoliths are cast-to-shape and are tunable for charge and hydrophobicity...
  21. ncbi Wrist arthrodesis using an embedded iliac crest bone graft
    E Lenoble
    Department of Orthopaedic Surgery and Traumatology, , , France
    J Hand Surg Br 18:595-600. 1993
    ..No fixation device is used. A short-arm cast is applied for 2 to 3 months. All arthrodeses except two fused within 3 months...
  22. ncbi [Clinical manifestation and patho-typing of biliary cast syndrome in patients after orthotopic liver transplantation]
    Xiao Dan Zhu
    Institute of Liver Transplantation, General Hospital of Chinese Armed Police Forces, Beijing 100039, China
    Zhonghua Wai Ke Za Zhi 46:728-32. 2008
    To summarize the Patho-typing and the clinical manifestation of biliary cast syndrome (BCS) in patients after orthotopic liver transplantation.
  23. ncbi Long-term survival of cast-gold inlays in a specialized dental practice
    H Erpenstein
    Department of Preclinical Dentistry, University of Cologne, Germany
    Clin Oral Investig 5:162-6. 2001
    ..0% (+/- 45.3) of one-surface inlays, 64.3 (+/- 7.5) of two-surface inlays, 75.8% (+/- 7.6) of three-surface inlays, and 84.8% (+/- 5.4) of inlays with more than three surfaces were still in situ after 25 years...
  24. ncbi Treatment of supracondylar humerus fractures in children: minimal possible duration of immobilization
    S Vuckov
    Department of Pediatric Surgery, University Hospital Center, University of Rijeka, Croatia
    Coll Antropol 25:255-62. 2001
    ..Three (2.4%) patients had no displacement of fractured bones and were treated only with plaster cast immobilization. Twenty three (18.1%) underwent closed reduction of fragments and application of a plaster cast...
  25. ncbi Computer-assisted minimally invasive treatment of osteochondrosis dissecans of the talus
    Ralf Ernst Rosenberger
    Universitätsklinik für Unfallchirurgie und Sporttraumatologie, Medizinische Universität Innsbruck MUI, Innsbruck, Osterreich
    Oper Orthop Traumatol 18:300-16. 2006
  26. ncbi Siloxane-based biocatalytic films and paints for use as reactive coatings
    Y Kim
    Department of Chemical Engineering, University of California, Berkeley, California 94720, USA
    Biotechnol Bioeng 72:475-82. 2001
    ..immobilized by either sol-gel entrapment or by covalent attachment into a polydimethylsiloxane (PDMS) matrix and cast into thin films or incorporated into an oil-based paint formulation...
  27. ncbi Comparison of titanium elastic nails with traction and a spica cast to treat femoral fractures in children
    John M Flynn
    Division of Orthopaedics, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    J Bone Joint Surg Am 86:770-7. 2004
    ..the risks and benefits of this procedure compared with those of traditional traction and application of a spica cast. This prospective cohort study was designed to evaluate these two methods of treatment, with a specific focus on ..
  28. ncbi Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction. A possible explanation for increased mortality in the Cardiac Arrhythmia Suppression Trial (CAST)
    J L Anderson
    University of Utah, LDS Hospital, Salt Lake City 84143
    Circulation 90:2843-52. 1994
    The Cardiac Arrhythmia Suppression Trial (CAST) was designed to test the hypothesis that suppression of ventricular ectopy with antiarrhythmic drugs after a myocardial infarction reduces the incidence of sudden arrhythmic death...
  29. ncbi [Botulinum toxin for postoperative care after limb surgery in cerebral palsy children]
    B Dohin
    Service de Chirurgie Pediatrique, Hopital Edouard Herriot, Hospices Civils de Lyon, 69437 Lyon Cedex 03
    Rev Chir Orthop Reparatrice Appar Mot 93:674-81. 2007
    ..Moreover, symptoms can be worsened by abnormal movements, cast immobilization or anxiety. Spasticity must therefore be treated after surgery in CP children...
  30. pmc Clinical evaluation of carbon fiber reinforced carbon endodontic post, glass fiber reinforced post with cast post and core: A one year comparative clinical study
    Ga Preethi
    Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore 560 002, India
    J Conserv Dent 11:162-7. 2008
    ..This clinical study compares two different varieties of fiber posts and one cast post and core in terms of mobility of crown margin under finger pressure, recurrent caries detected at the crown ..
  31. ncbi Seat belt fracture with late development of an enterocolic fistula in a child. A case report
    M Letts
    Division of Pediatric Orthopaedics, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    Spine (Phila Pa 1976) 24:1151-5. 1999
    ..RESULTS: The subtle and prolonged symptomatology of this lesion and its similarity to a cast syndrome is emphasized...
  32. ncbi Effect of pressure of helium, argon, krypton, and xenon on the porosity, microstructure, and mechanical properties of commercially pure titanium castings
    S Zinelis
    Research Center for Biomaterials, Athens, Greece
    J Prosthet Dent 84:575-82. 2000
    ..Porosity is a frequently observed casting defect in dental titanium alloys...
  33. ncbi [Controlled randomized clinical trials]
    Patrice Jaillon
    Pharmacologie, Hôpital Saint Antoine AP HP et Faculté de Médecine Pierre et Marie Curie
    Bull Acad Natl Med 191:739-56; discussion 756-8. 2007
    ..Practitioners' intimate convictions must be challenged by the results of controlled clinical trials. Take the CAST trial for example, which, in 1989, tested antiarrhythmic drugs versus placebo in patients with myocardial ..
  34. ncbi Scaphoid fracture displacement with forearm rotation in a short-arm thumb spica cast
    S A Kaneshiro
    Department of Orthopaedic Surgery, Henry Ford Hospital, Detroit, MI, USA
    J Hand Surg Am 24:984-91. 1999
    ..scaphoid waist fracture was measured during dynamic forearm pronation and supination in a short-arm thumb spica cast with and without applied tendon loads...
  35. ncbi Early dynamic motion versus postoperative immobilization in patients with extensor indicis proprius transfer to restore thumb extension: a prospective randomized study
    G Germann
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Germany
    J Hand Surg Am 26:1111-5. 2001
    ..Ten patients of each group had the thumb immobilized in an extension thumb spica cast for 3 weeks after surgery or underwent an early dynamic motion protocol...
  36. doi Effects of tooth preparation burs and luting cement types on the marginal fit of extracoronal restorations
    Mohamed F Ayad
    Section of Restorative Dentistry, Prosthodontics, and Endodontics, College of Dentistry, University of Tanta, Egypt
    J Prosthodont 18:145-51. 2009
    Although surface roughness of axial walls could contribute to precision of a cast restoration, it is unclear how the roughness of tooth preparation affects marginal fit of the restoration in clinical practice...
  37. doi Pain mitigation after band castration of beef calves and its effects on performance, behavior, Escherichia coli, and salivary cortisol
    L A Gonzalez
    Agriculture and Agri Food Canada, Lethbridge Research Centre, Lethbridge, Alberta T1J 4B1, Canada
    J Anim Sci 88:802-10. 2010
    ..randomly assigned to a 2 x 2 factorial arrangement of treatments to study the effect of sham or band castration (CAST) with or without pain medication (MED) on performance, behavior, cortisol, and Escherichia coli shedding...
  38. ncbi [Intermediary and substitution criteria in the development of anti-arrhythmia agents]
    M Lievre
    Unite de Pharmacologie Clinique, Lyon
    Arch Mal Coeur Vaiss 84:27-33. 1991
    ..infarction can only be beneficial, has been queried by the results of the Cardiac Arrhythmia Suppression Trial (CAST) which showed increased mortality in two treatment groups...
  39. ncbi The effect of a plaster cast on lumbosacral joint motion. An in vivo assessment with precision motion analysis system
    P C Willems
    Department of Orthopaedic Surgery, Sint Maartenskliniek, Nijmegen, The Netherlands
    Spine (Phila Pa 1976) 22:1229-34. 1997
    STUDY DESIGN: This study was conducted to assess the effect of a plaster cast on the mobility of the lumbosacral joint in 10 patients with chronic low back pain...
  40. ncbi The phosphorylation state of the 110 kDa component of the yeast spindle pole body shows cell cycle dependent regulation
    D A Stirling
    Department of Biochemistry, University of Dundee, United Kingdom
    Biochem Biophys Res Commun 222:236-42. 1996
    The 110 kDa component of the yeast spindle pole body (SPB) encoded by the SPC110/NUF1 gene is an essential protein which is important for the generation of a functional mitotic spindle in the yeast Saccharomyces cerevisiae...
  41. ncbi [What remains of anti-arrhythmia drugs?]
    S Levy
    Service de cardiologie, Hopital Nord, Marseille
    Arch Mal Coeur Vaiss 86:1501-5. 1993
    ..It has underlined the complexity of the mechanism of action of antiarrhythmic therapy. The CAST study has shown that the use of antiarrhythmic therapy following a myocardial infarction may not be safe...
  42. ncbi [Anticoagulation and antiaggregation: implication in the acute phase of stroke following IST, CAST, TOAST, FISS and FISS bis]
    J J Muñoz-Torrero
    Servicio de Neurologia, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Espana
    Rev Neurol 29:769-80. 1999
    ..One of the therapeutic strategies in the acute phase of cerebral ischaemia is the use of antiaggregants and anticoagulants...
  43. ncbi [Methodology in clinical trials of anti-arrhythmia agents in ventricular arrhythmias. Analysis and perspective following results of the CAST study]
    P Jaillon
    , , Paris
    Arch Mal Coeur Vaiss 84:35-40. 1991
    The results of the Cardiac Arrhythmia Suppression Trial (CAST) have not finished modifying the methodology and strategy of development of new antiarrhythmic agents for the treatment of ventricular arrhythmias...
  44. ncbi The influence of open leaflet geometry on the haemodynamic flow characteristics of polyurethane trileaflet artificial heart valves
    J Corden
    Department of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 210:273-87. 1996
    ..The film-fabricated valve was constructed from solvent-cast sheets of polyurethane, thermally formed into the correct leaflet geometry...
  45. ncbi Use of CD63 expression as marker of in vitro basophil activation in identifying the culprit in insect venom allergy
    B Eberlein-König
    Department of Dermatology and Allergy Biederstein, Technical University Munich Division Environmental Dermatology and Allergology GSF TUM, Neuherberg Munich, Germany
    J Investig Allergol Clin Immunol 14:10-6. 2004
    ..In cases with contradictory test results additional cellular tests are recommended...
  46. ncbi The effect of an age-related hearing loss gene (Ahl) on noise-induced hearing loss and cochlear damage from low-frequency noise
    Gary W Harding
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 204:90-100. 2005
    ..Assoc. Res. Otolaryngol. 2 (2001) 233]. Johnson et al. [Hear. Res. 114 (1997) 83] developed a congenic B6.CAST-+Ahl mouse which carries the wild-type allele from Mus musculus castaneus at the Ahl locus...
  47. ncbi Functional restoration. Returning patients with chronic low back pain to work--revolution or fad?
    R W Teasell
    Department of Physical Medicine and Rehabilitation, University Hospital, London, Ontario, Canada
    Spine (Phila Pa 1976) 21:844-7. 1996
    ..A review was performed to assess the basis for functional restoration programs in returning patients with chronic low back pain to work...
  48. ncbi Inhibition of bacterial alpha-glucosidases by castanospermine in pure cultures and activated sludge
    N Mustafa
    Department of Cell and Molecular Biology, Microbiology, Goteborg University, P O Box 462, 40530 Goteborg, Sweden
    Appl Microbiol Biotechnol 59:68-71. 2002
    Castanospermine (CAST) is a known and potent inhibitor of various alpha-glucosidases in eukaryotes...
  49. ncbi Failure of cast immobilization for thumb ulnar collateral ligament avulsion fractures
    M Dinowitz
    Department of Orthopaedics, University of Washington, Harborview Medical Center, Seattle, WA, USA
    J Hand Surg Am 22:1057-63. 1997
    ..0 mm) displacement can successfully be treated by cast immobilization, the authors reviewed 9 patients with minimally displaced fractures initially treated by casting...
  50. ncbi The effect of kinematic conditions on the wear of ultra-high molecular weight polyethylene (UHMWPE) in orthopaedic bearing applications
    G B Cornwall
    Marco Pore, San Diego, California, USA
    Proc Inst Mech Eng H 215:95-106. 2001
    ..All static load tests used cast Co-Cr alloy and irradiated Chirulen UHMWPE in a 37 degrees C environment lubricated with bovine serum albumin...
  51. pmc Elective ventilation of potential organ donors
    H Riad
    Royal Devon and Exeter Hospital
    BMJ 310:714-5. 1995
    ..Recently doubt has been cast on the legality of our practice of elective ventilation on the grounds that relatives are not permitted to consent ..
  52. ncbi Power staple fixation in trapeziometacarpal arthrodesis
    R J Caputo
    Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030
    J Hand Surg Am 18:926-9. 1993
    ..Short arm thumb spica cast immobilization was maintained for an average of 8 weeks, followed by part-time splintage for 6-12 weeks...
  53. ncbi Corono-radicular reconstruction of pulpless teeth: a mechanical study using finite element analysis
    Laurent Pierrisnard
    Faculty of Dental Surgery, University of Paris V, Montrouge, France
    J Prosthet Dent 88:442-8. 2002
    ..The likelihood of a fracture depends on the condition of the crown and the type of reconstruction performed...
  54. ncbi Scapholunate ligament reconstruction using a bone-retinaculum-bone autograft
    A P Weiss
    Department of Orthopaedic Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
    J Hand Surg Am 23:205-15. 1998
    ..The SL interval was reduced and pinned for 8 weeks with cast immobilization. The follow-up period averaged 3.6 years (minimum, 24 months)...
  55. ncbi [Role of antiarrhythmics in the post-infarction period]
    S Dinanian
    Service de cardiologie, , Clamart
    Arch Mal Coeur Vaiss 93:65-9. 2000
    ..Class I antiarrhythmics, though, should be proscribed after the results of the CAST studies: these antiarrhythmics are effective on ventricular arrhythmias but do not improve the prognosis because of ..
  56. ncbi [Madrid adaptation of the Wisconsin card sorting test: a comparative study of internal consistency]
    J A Periáñez
    Departamento Psicología Básica II Universidad Complutense de Madrid Facultad de Psicología, Madrid, 28223, Espana
    Rev Neurol 33:611-8. 2001
    WCST (Wisconsin Card Sorting Test) is still a widely used neuropsychological test for evaluation of disorders of the frontal lobes. Recent studies have cast doubt on the validity of WCST as a marker for frontal dysfunction.
  57. ncbi Surface detail, compressive strength, and dimensional accuracy of gypsum casts after repeated immersion in hypochlorite solution
    Mohammed Aleem Abdullah
    Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Kingdom of Saudi Arabia
    J Prosthet Dent 95:462-8. 2006
    One method used to disinfect a dental cast is immersion in a disinfecting solution. Repeated immersion of a cast in disinfectant may affect surface detail as well as other physical properties.
  58. ncbi Salvage reconstruction with vascularized fibular strut graft fusion using posterior approach in the treatment of severe spondylolisthesis
    A M Meyers
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Spine (Phila Pa 1976) 26:1820-4. 2001
    ..After the procedure the patient was placed in a hip spica cast. RESULTS: At the 2-year follow-up the patient has incorporation of the graft, with no evidence of fracture and no ..
  59. pmc Interaction of ischaemia and encainide/flecainide treatment: a proposed mechanism for the increased mortality in CAST I
    H M Greenberg
    Division of Cardiology, St Luke s Roosevelt Hospital, New York, NY 10019, USA
    Br Heart J 74:631-5. 1995
    To determine whether an interaction between encainide or flecainide and intercurrent ischaemia could account for the observed increase in cardiac and sudden deaths in the study group in the Cardiac Arrhythmia Suppression Trial (CAST) I.
  60. ncbi Seizure-induced lumbar burst fracture
    J A Youssef
    Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Spine (Phila Pa 1976) 20:1301-3. 1995
    ..Initial treatment using a Risser cast was unsuccessful, and the patient subsequently underwent posterior spine fusion with Cotrel-Dubousset segmental ..
  61. ncbi Cultivation of the third-stage larvae of Necator americanus in vitro
    H Hata
    Department of Parasitology, Chiba University School of Medicine, Japan
    Ann Trop Med Parasitol 86:157-62. 1992
    ..In this medium, most of the filariform larvae cast off the second sheath and developed into third-stage larvae with provisional buccal capsules and some larvae ..
  62. ncbi Psychophysiological parameters of migraine and muscle-contraction headaches
    K L Lichstein
    Department of Psychology, Memphis State University, Tennessee 38152
    Headache 31:27-34. 1991
    ..Self-reported pain was uncorrelated with the psychophysiological indices. These results cast further doubt on the validity of the psychophysiological measures employed in this study, the same ones routinely ..
  63. ncbi Prediction of secondary displacement in Colles' fracture
    L M Hove
    Department of Orthopaedics and Traumatology, Haukeland University Hospital, Norway
    J Hand Surg Br 19:731-6. 1994
    ..The mean shortening of the radius during plaster-cast treatment was 3 mm, and the mean increase of dorsal angulation was 7 degrees...
  64. ncbi In vitro determination of the curvatures and bending strains acting on the leaflets of polyurethane trileaflet heart valves during leaflet motion
    J Corden
    Department of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 209:243-53. 1995
    ..Valves manufactured using a dip-casting technique resulted in open leaflet bending strains up to 31 per cent lower than valves manufactured from solvent-cast sheets of polyurethane.
  65. ncbi Radiocarpal dislocations: classification and proposal for treatment. A review of twenty-seven cases
    C Dumontier
    Institut de la Main, Paris, France
    J Bone Joint Surg Am 83:212-8. 2001
    ..There have been only two reported series of more than eight patients. Thus, there are many questions concerning treatment and functional results...
  66. ncbi Influence of recasting palladium-silver alloy on the fit of crowns with different marginal configurations
    Murilo B Lopes
    Department of Operative Dentistry, Dentistry School of Piracicaba, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    J Prosthet Dent 94:430-4. 2005
    Dental laboratories may occasionally recast previously cast dental alloy to produce a prosthesis, but this process may have a negative influence on marginal adaptation.
  67. ncbi Modeling the investment casting of a titanium crown
    R C Atwood
    Department of Materials, Imperial College London, London, UK
    Dent Mater 23:60-70. 2007
    ..The model should also be validated by comparison of macro- and micro-defects found in a typical investment cast titanium tooth crown.
  68. ncbi A comparison of two methods of removing zinc oxide-eugenol provisional cement residue from the internal surface of cast restorations
    Ramin Mosharraf
    Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
    J Contemp Dent Pract 10:27-34. 2009
    Remnants of provisional cement on the internal surface of cast restorations can have an adverse effect on the performance of the definitive luting agent...
  69. ncbi The Cardiac Arrhythmia Suppression Trial: first CAST ... then CAST-II
    H L Greene
    Department of Medicine, University of Washington, Seattle
    J Am Coll Cardiol 19:894-8. 1992
    The Cardiac Arrhythmia Suppression Trial (CAST) was a study designed to test the hypothesis that suppression of ventricular premature complexes after a myocardial infarction would improve survival...
  70. ncbi Laser digitization of casts to determine the effect of tray selection and cast formation technique on accuracy
    Mary E Brosky
    Division of Prosthodontics, Department of Restorative Sciences, School of Dentistry, University of Minnesota, Minneapolis 55455, USA
    J Prosthet Dent 87:204-9. 2002
    ..determine the ideal combination of dental materials and laboratory techniques to produce the most accurate dental cast. Most have made use of 2-dimensional manual measuring devices, which neglect to account for the dimensional changes ..
  71. doi Comparison of the bond strength of laser-sintered and cast base metal dental alloys to porcelain
    Tolga Akova
    Department of Prosthodontics, Faculty of Dentistry, Cukurova University 01330 Balcali, Adana, Turkey
    Dent Mater 24:1400-4. 2008
    The purpose of this study was to compare shear bond strengths of cast Ni-Cr and Co-Cr alloys and the laser-sintered Co-Cr alloy to dental porcelain.
  72. ncbi Fractures of the distal radius and scaphoid
    J Oskam
    Department of Surgery, Academic Hospital, University of Groningen, The Netherlands
    J Hand Surg Br 21:772-4. 1996
    ..An extraarticular distal radial fracture was observed in 15 wrists. A below elbow cast including the thumb was applied in 18 wrists for a mean duration of 9 weeks, and operative treatment was used in ..
  73. ncbi Can the use of a terminal device augment plantar pressure reduction with a total contact cast?
    Raja Dhalla
    Washington University Barnes Jewish Hospital, St Louis, MO, USA
    Foot Ankle Int 24:500-5. 2003
    ..The purpose of this study was to determine if terminal cast devices (cast shoes and heels) significantly affect the amount of plantar pressure reduction when used with a total ..
  74. doi Gait analysis of children treated for clubfoot with physical therapy or the Ponseti cast technique
    Ron El-Hawary
    Division of Pediatric Orthopaedics, Isaac Walton Killam Health Centre, 5850 University Avenue, P O Box 9700, Halifax, NS B3K 6R8, Canada
    J Bone Joint Surg Am 90:1508-16. 2008
    Currently, clubfoot is initially treated with nonoperative methods including the Ponseti cast technique and the French functional physical therapy program. Our goal was to evaluate the function of children treated with these techniques.
  75. ncbi Closed reduction of spondylolisthesis. An experience in 22 patients
    D S Bradford
    Department of Orthopaedic Surgery, University of Minnesota, Minneapolis
    Spine (Phila Pa 1976) 13:580-7. 1988
    ..Postoperatively, two patients were immobilized in an ambulatory extension brace, 15 patients in a body cast incorporating one thigh, and five patients in a body cast incorporating Hoffman iliac pins and lumbar spinous ..
  76. ncbi The halo-Milwaukee brace. Case series of a revived technique
    D H Godfried
    Shriners Hospitals for Crippled Children, Chicago, Illinois, USA
    Spine (Phila Pa 1976) 24:2273-7. 1999
    ..of the neck and upper thorax can be achieved with cervical orthoses, cervicothoracic lumbar orthosis, halo cast, Minerva jacket, or halo vest...
  77. ncbi Atypical varicella exanthems associated with skin injury
    T H Belhorn
    Division of Pediatric Infectious Diseases, University of Texas Health Science Center, Houston
    Pediatr Dermatol 11:129-32. 1994
    ..a neonate had iatrogenic trauma to her arm, and a 13-year-old boy underwent knee arthroscopy and was wearing a cast. It is postulated that such injuries to the skin either allowed more virus-infected cells to enter the skin at the ..
  78. ncbi Cardiac paraprotein associated with Waldenstrom's macroglobulinemia: a case report
    R L Yowell
    LDS Hospital Electron Microscopy Laboratory, Salt Lake City, Utah
    Ultrastruct Pathol 18:229-32. 1994
    ..light microscopy revealed diffuse widening of interstitial regions by pale eosinophilic material that had a grayish cast on trichrome stains and was Congo red negative...
  79. ncbi Nefazodone and REM sleep: how do antidepressant drugs decrease REM sleep?
    G Vogal
    Sleep Research Laboratory, Inc, Atlanta, GA USA
    Sleep 21:70-7. 1998
    ..Since N is a potent serotonin reuptake blocker, the present findings that N had no effect on REM sleep cast doubt on the hypothesis that antidepressant drugs decrease REM sleep by increasing serotonergic neurotransmission...
  80. ncbi Arthrodesis as an early alternative to nonoperative management of charcot arthropathy of the diabetic foot
    S R Simon
    Department of Orthopaedic Surgery, Beth Israel Medical Center, New York, NY 10128, USA
    J Bone Joint Surg Am 82:939-50. 2000
    ..the standard treatment of stage-I Charcot arthropathy is the application of a non-weight-bearing total-contact cast. Although this treatment can be effective for allowing a patient to walk without undergoing an operation, a ..
  81. ncbi Electrochemical characterization of cast titanium alloys
    Zhuo Cai
    Baylor College of Dentistry, Texas A and M University System Health Science Center, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Biomaterials 24:213-8. 2003
    A reaction layer forms on cast titanium alloy surfaces due to the reaction of the molten metal with the investment. This surface layer may affect the corrosion of the alloy in the oral environment...
  82. doi Effect of cement selection and finishing technique on marginal opening of cast gold inlays
    Charles V Farrell
    Department of Restorative Dentistry, School of Dentistry, University of Washington, Seattle, WA 98225 4035, USA
    J Prosthet Dent 99:287-92. 2008
    The standard cement for partial-veneer cast gold restorations has been zinc phosphate...
  83. pmc Comparison of Ponseti and Kite's method of treatment for idiopathic clubfoot
    Raju Rijal
    Department of Orthopedics, BPKIHS, Dharan, Nepal
    Indian J Orthop 44:202-7. 2010
    The manipulation and corrective cast application for club foot was known to be done by Kite's method...
  84. ncbi Failure of trapeziometacarpal arthrodesis with use of the Herbert screw and limited immobilization
    D A Clough
    Division of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030
    J Hand Surg Am 15:706-11. 1990
    ..9 mm Herbert screw for internal fixation. Thumb spica cast immobilization was maintained for an average of 8 weeks, followed by thumb spica orthoplast splintage on a part ..
  85. ncbi Allograft bone use during instrumentation and fusion in the treatment of adolescent idiopathic scoliosis
    J S Blanco
    Department of Orthopedic Surgery, University of Virginia Health Sciences Center, Charlottesivlle, USA
    Spine (Phila Pa 1976) 22:1338-42. 1997
    ..Studies in the pediatric population have been more favorable but in idiopathic cases have used cast or brace immobilization with Harrington instrumentation...
  86. ncbi Cognitive strategies versus self-management skills as adjunct to vocational rehabilitation
    Roland Vauth
    Research Group of Cognitive Behavioral Intervention for Schizophrenia, Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Germany
    Schizophr Bull 31:55-66. 2005
    ..Therefore, two cognitive-behavioral group therapies were developed-computer-assisted cognitive strategy training (CAST) and training of self-management skills for negative symptoms (TSSN)-to target these barriers to rehabilitation ..
  87. ncbi Impact of manufacturing technology and material composition on the surface characteristics of hydrogel contact lenses
    Carole Maldonado-Codina
    Eurolens Research, Faculty of Life Sciences, The University of Manchester, Moffat Building, PO Box 88, Manchester, M60 1QD, United Kingdom
    Clin Exp Optom 88:396-404. 2005
    ..Our aim was to investigate the impact of manufacturing method and material composition on the surface characteristics of hydrogel contact lenses...
  88. ncbi Above and below-the-elbow plaster casts for distal forearm fractures in children. A randomized controlled trial
    Eric R Bohm
    University of Manitoba Joint Replacement Group, Concordia General Hospital, 1095 Concordia Avenue, Winnipeg, MB R2K 3S8, Canada
    J Bone Joint Surg Am 88:1-8. 2006
  89. ncbi The "Amex" cast aluminum denture of World War I
    J M Hyson
    Baltimore College of Dental Surgery, Dental School, University of Maryland, 31 South Greene Street, Baltimore, Maryland, 21201-1504, USA
    J Hist Dent 49:89-91. 2001
    ..James Baxter Bean, the Confederate dental surgeon who established the first military maxillofacial hospital trauma ward in Atlanta, Georgia, during the American Civil War--the cast aluminum wartime denture.
  90. ncbi Three cast techniques for the treatment of extra-articular metacarpal fractures. Comparison of short-term outcomes and final fracture alignments
    Jeff Tavassoli
    Bone and Joint Sports Medicine Institute, Charette Health Sciences Center, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA
    J Bone Joint Surg Am 87:2196-201. 2005 that the metacarpophalangeal joint should be immobilized in a position of flexion, alternative methods for cast immobilization have been described...
  91. ncbi Effect of heat treatment on mechanical properties of age-hardenable gold alloy at intraoral temperature
    I Watanabe
    Department of Fixed Prosthodontics, Nagasaki University, School of Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Dent Mater 17:388-93. 2001
    ..The aim of this study was to investigate the effect of various heat treatments on the mechanical properties of gold alloys capable of age-hardening at intraoral temperature...
  92. ncbi Isolated spinous process deviation. A pitfall in the interpretation of AP radiographs of the lumbar spine
    J P van Schaik
    Department of Diagnostic Radiology, University Hospital Utrecht, The Netherlands
    Spine (Phila Pa 1976) 14:970-6. 1989
    ..Since the oval shadow cast by the spinous process in AP radiographs is caused by its tip, rather than by its base (as was demonstrated by in ..
  93. ncbi The effects of postoperative continuous passive motion on peripheral nerve repair and regeneration. An experimental investigation in rabbits
    H K Kim
    Hospital for Sick Children Research Institute, Toronto, Canada
    J Hand Surg Br 23:594-7. 1998
    ..Half of the animals were treated with cast immobilization and the rest with 70 degrees arc CPM. Both treatments were discontinued on day 14...
  94. ncbi Cerebral cast angiography as an aid to medicolegal autopsies in cases of death after adult cardiac surgery
    E Saimanen
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Finland
    Int J Legal Med 114:163-8. 2001
    ..In order to reveal cerebral pathology associated with a fatal outcome after cardiac surgery, we re-evaluated the cast angiographs and medico-legal autopsy documents of 144 adult cardiac surgery subjects over a 7-year period...
  95. doi Cellular in vitro assays in the diagnosis of Hymenoptera venom allergy
    K Scherer
    Allergy Unit, Department of Dermatology, University Hospital Basel, Basel, Switzerland
    Int Arch Allergy Immunol 146:122-32. 2008
    ..Sometimes, the culprit insect remains unidentified. The usefulness of the cellular assays CAST-ELISA and Flow-CAST in the management of hymenoptera venom allergy was investigated.
  96. doi Retention of cast crown copings cemented to implant abutments
    J E Dudley
    Faculty of Health Sciences, School of Dentistry, The University of Adelaide, South Australia
    Aust Dent J 53:332-9. 2008
    ..This study investigated the influence of compressive cyclic loading on the physical retention of cast crown copings cemented to implant abutments.
  97. ncbi Compositional stability and marginal accuracy of complete cast crowns made with as-received and recast type III gold alloy
    Mohamed F Ayad
    Section of Restorative Dentistry, Prosthodontics, and Endodontics, College of Dentistry, University of Tanta, Tanta, Egypt
    J Prosthet Dent 87:162-6. 2002
    ..The effect of combining new and recast metal on the compositional stability of the alloy used and accuracy of the final restoration is not known...
  98. ncbi Ozone-induced acute pulmonary injury in inbred mouse strains
    Jordan D Savov
    Department of Medicine, Duke University Medical Center and VA Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 31:69-77. 2004
    ..of nine genetically diverse inbred strains of mice (C57BL/6J, 129/SvIm, BTBR, BALB/cJ, DBA/2J, A/J, FVB/NJ, CAST/Ei, and C3H/HeJ) exposed to O3 (2.0 ppm x 3 h)...
  99. ncbi Clinical outcome of the altered cast impression procedure compared with use of a one-piece cast
    Richard P Frank
    Department of Prosthodontics, School of Dentistry, University of Washington, Seattle, 98195 7452, USA
    J Prosthet Dent 91:468-76. 2004
    An altered cast impression procedure to improve the support of distal extension removable partial dentures is widely taught, but not often used in dental practice.
  100. ncbi An in vitro comparison of cast metal dowel retention using various luting agents and tensile loading
    H Zeynep Ertugrul
    School of Dental Medicine, Department of Prosthodontics, University of Pittsburg, Pittsburg, PA 15261, USA
    J Prosthet Dent 93:446-52. 2005
    No clear consensus exists regarding the choice of luting agents for the retention of cast metal dowels used as a treatment alternative for endodontically treated teeth with excessive loss of coronal tooth structure.
  101. ncbi Surface and elemental alterations of dental alloys induced by electro discharge machining (EDM)
    Spiros Zinelis
    Department of Biomaterials, School of Dentistry, University of Athens, Thivon 2, Goudi 115 27, Athens, Greece
    Dent Mater 23:601-7. 2007
    To evaluate the surface and elemental alterations induced by electro discharge machining (EDM) on the surface of dental cast alloys used for the fabrication of implant retained meso- and super-structures.

Research Grants71

  1. Understanding interface initiated fractures in glass-ceramic restorations
    ROBERT R contact SEGHI; Fiscal Year: 2011
    ..In an ideal scenario, we would use these restoration types in much the same manner that we utilized cast metal in the previous century...
  2. Fabrication of Denture Frameworks Using Titanium Alloys
    Marie Koike; Fiscal Year: 2010
    ..The three aims of the study are: 1) to determine the feasibility of fabricating sound removable denture frameworks cast from titanium alloys;2) to evaluate the retentive force and the attenuation of the retentive force of the clasp ..
    Stephen Cohen; Fiscal Year: 1991
    ..castability characteristics in dental alloys are critical for the consistent production of sound, well fitting cast restorations without the necessity of frequent costly and time consuming remakes...
    Steven G Clarke; Fiscal Year: 2013
    ..Our overall goal is to establish the complete cast of characters of the enzymes that catalyze these modifications in nature so that their functions, especially in ..
  5. Andrew H Hansen; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Immobilization of the ankle using a walking cast or boot is a common treatment to relieve pain...
  6. Regulation and Role of Ornithine Decarboxylase in Cell Proliferation and Cancer
    John L Cleveland; Fiscal Year: 2013
    ..transcription factors is activated in ~70% of human cancers and they regulate the transcription of a large cast (10-15%) of the genome to coordinate metabolism, cell growth and division, differentiation, and development...
  7. Negative regulation by thyroid hormone
    Anthony N Hollenberg; Fiscal Year: 2010
    ..In addition to relieving repression, TH further activates gene expression by allowing the TR to recruit a cast of coactivators which act as histone-modifying enzymes and enhance transcription...
  8. Role of Calpastatin in mutant SOD1-mediated motor neuron disease
    Mala V Rao; Fiscal Year: 2010
    ..The best way to inactivate this protease is to inhibit with its own endogenous inhibitor calpastatin (CAST). We have developed a transgenic mouse line that expresses very high levels of CAST in motor neurons...
  9. Characterizing the effects of Mouse Maturation on the Expression of Acute Renal F
    Richard A Zager; Fiscal Year: 2010 least three ARF models, 4 month old mice subjected to the same injury protocols sustain severe tubular necrosis, cast formation, and filtration failure...
  10. Genetic dissection of the role of macrophages in axonal myelination in zebrafish
    Celia E Shiau; Fiscal Year: 2012
    ..This project will cast light on the potential causes of a wide array of neurological disorders derived from aberrant immune function, and ..
  11. Peter J Mohler; Fiscal Year: 2015
    ..For this first competitive renewal, we present a cast of uncharacterized and innovative animal models, novel molecular tools, innovative technologies, and new antibodies ..
  12. Wade S Kingery; Fiscal Year: 2014
    ..2) to determine whether sensory and sympathetic efferent signaling is up-regulated after fracture and three- week cast immobilization in mice and to establish the role this neuronal signaling plays in the development of post-fracture ..
  13. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn E Carroll; Fiscal Year: 2012
    ..will be compared: a) ovariectomized females (OVX), b) OVX with estrogen replacement (OVX + E), c) castrated males (CAST), d) sham-operated females (SHAM) and e) SHAM males...
  14. ANDREW ROBERT JUDGE; Fiscal Year: 2015
    ..muscle atrophy is the FOXO family, and FOXO signaling is increased in a variety of atrophy conditions, including cast immobilization, sepsis, cancer and starvation...
  15. Polysaccharide Ecocomposite Materials: Recyclable Synthesis and Applications
    Chieu D Tran; Fiscal Year: 2012
    ..The resulting IL solutions will then be cast into thin films, and [BMIm] will be removed from the films by soaking the films in water...
  16. Telomeres and Telomerase in Stem Cell Failure and Aging
    Carol W Greider; Fiscal Year: 2010
    ..We have generated a line of telomerase RNA null (mTR-/-) mice on the CAST/EiJ genetic background that has short telomeres, similar to telomere length in humans...
  17. A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial Stents
    Guillermo A Ameer; Fiscal Year: 2010
    ..Thus, our hypothesis is that a liquid cast NO-eluting biodegradable PDC stent will have superior patency rates compared to conventional bare metal stents ..
  18. David J Clark; Fiscal Year: 2014
    ..4 main objectives: 1) to identify which components of CRPS are well modeled in the setting of human hand surgery/cast immobilization, 2) to acquire sufficient preliminary data to allow estimation of effect size and variance in our ..
  19. Sclerostin and Gsalpha signaling in osteoblasts
    JOY Y WU; Fiscal Year: 2012
    ..Although fractures call forth images from childhood of a limb in a cast, soliciting autographs and sympathy during a brief period of recovery, fragility fractures in the elderly are far ..
  20. Role of HIV-1 Tat in the activation of HERV-K and development of HIV-1-lymphoma
    MARTA JEANNETTE GONZALEZ-HERNANDEZ; Fiscal Year: 2011 elucidate the mechanisms by which an endogenous retrovirus, HERV-K, is activated in HIV-infected individuals, cast light on the mechanisms by which these viruses could contribute to the pathogenesis of lymphoma, and perhaps ..
  21. Interactive Sensor Technology to Measure Adherence to Prescribed Therapeutic Foot
    Bor Rong Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Prescribed footwear, such as Removable Cast Walkers, are used to reduce harmful pressures on the bottom of the foot for prevention and treatment of diabetic foot ulceration (DFU)...
  22. Pulmonary Formulation of tPA for Plastic Bronchitis
    Kathleen A Stringer; Fiscal Year: 2010
    ..aims will be tested: 1) To prove pf-tPA effectiveness in PB by identifying a range of concentrations that reduce cast mass. We will acquire casts from a cohort of University of Michigan pediatric PB patients...
  23. Bradley S Peterson; Fiscal Year: 2015
    Summary Children's neurocognitive development can cast long shadows on their futures, dramatically influencing their occupational functioning and psychosocial adjustment...
  24. Role of Macrophage Activation in Carotid Plaque Instability
    Michelle R Lennartz; Fiscal Year: 2010
    ..b>Cast and cuffs will be implanted in Apo E-/- mice expressing activating or inhibitory Fc?R...
  25. Identification of Gender Specific BMD Candidate Gene in Chromosome 1
    Bouchra Edderkaoui; Fiscal Year: 2011
    ..Based on our recent findings that femurs from C57BL/6J (B6)-Castaneous (CAST) congenic mice carrying CAST alleles at D1mit115-D1mit152 (178-185 Mb, named BMD1-4 QTL) exhibit significantly ..
  26. Signaling and Therapeutics in Cell Death and Survival
    Zahra Zakeri; Fiscal Year: 2010
    ..Dr Eileen White will be the keynote speaker and will lead a panel discussion with an international cast. The full meeting will include sessions on alternative pathways to cell death;on cancer, immunity, aging and cell ..
  27. Kenneth Paigen; Fiscal Year: 2014
    ..of three hotspots whose activities are regulated by genes that differ between the mouse strains C57BL/6J and CAST/EiJ;two have their activity reduced by the presence of CAST alleles, and one has its activity enhanced...
  28. Improving islet transplantation outcome with Akt1
    Hongju Wu; Fiscal Year: 2013
    ..However, the limited supply and significant islet loss in the peritransplant period are cast as the major limitations of this treatment strategy...
  29. William R Roush; Fiscal Year: 2016
    ..human cancers, where they orchestrate wholesale changes in gene transcription that drive tumorigenesis, including a cast of metabolic enzymes...
  30. Interplay of Myc, Tumor Supressors and Regulators of Differentiation in Lymphoma
    John L Cleveland; Fiscal Year: 2012
    ..The pervasive selection for Myc activation in cancer reflects its essential roles in regulating a vast cast of targets (well over 10% of the genome), including those that coordinate and control cell growth (mass) and ..
  31. Molecular breast imaging to guide early-stage patient care
    JAMES W HUGG; Fiscal Year: 2011
    ..e., those women in whom shadows are difficult to cast. Dr...
  32. BARRY RICHARD KOMISARUK; Fiscal Year: 2016
    ..b>Cast a wide net to recruit potential IMSD students -- especially doctoral students, who are particularly ..
  33. NIMESH BHIKHU PATEL; Fiscal Year: 2015
    ..Although glial tissue and small retinal vessels cannot be visualized in SD-OCT scans, the major retinal vessels cast shadows on the underlying tissues, and can be accounted for...
  34. Genetics Modifiers of Anthrax Lethal Toxin Induced Pathophysiology
    KENNETH ALAN BRADLEY; Fiscal Year: 2010
    ..a rapidly induced phenotype was identified in a congenic strain of mice that has a chromosomal segment of the CAST/EiJ strain on an otherwise C57BL/6J background...
  35. Mark Winey; Fiscal Year: 2015
    ..Another important protein, Spc110, attaches the 3-tubulin complex to the SPB, and we will determine whether Spc110 phosphorylation is critical for 3-..
  36. Family Size and Children's Education in Brazil
    Leticia J Marteleto; Fiscal Year: 2013
    ..prediction that family size is negatively related to children's education, a recent stream of research has cast doubt on the homogeneity of these findings on conceptual and methodological grounds...
  37. Role of Presenilin Associated Protein (PSAP) in Apoptosis and in Abeta Formation
    Xuemin Xu; Fiscal Year: 2012
    ..However, the lack of a direct molecular link between presenilin and apoptosis has cast a shadow over these notions...
  38. Translating Addiction Genomics Research into Practice: Examining Ethics & Policy
    Barbara A Koenig; Fiscal Year: 2010
    ..associated with dependence will contribute to the emergence of a "genetic understanding of addiction" that may cast additional stigma on those affected or, if understood in an overly simplistic and deterministic way, may shift ..
  39. Effects of Outcome Cue Exposure on Alcohol-Related Cognition and Alcohol Use
    Denis M McCarthy; Fiscal Year: 2010
    ..If predictions are borne out empirically, the results of this interdisciplinary project stand to cast new light upon the manner in which situational cues impact both alcohol-related cognitive processing as well as ..
    STEVEN KINCAID; Fiscal Year: 1991
    ..A fifth group of 4 dogs will serve as untreated controls. On day 56, the cast will be replaced with casts containing injection portals...
  41. John L Cleveland; Fiscal Year: 2016
    ..or mitogenic signaling pathways, is a hallmark of rapidly dividing human leukemia and lymphoma, as well as a cast of other malignancies...
  42. Tobias Egner; Fiscal Year: 2016
    ..Second, visual information is inherently ambiguous, as many distinct objects can cast an identical retinal image, while a single object can cast many different images...
  43. Paul W Sanders; Fiscal Year: 2014
    ..The seminal observations that demonstrated the mechanism and functional significance of intraluminal cast formation have been published by this laboratory, and recent unpublished studies have provided critical proof of ..
  44. Molecular Signatures of Muscle Rehabilitation
    Krista Vandenborne; Fiscal Year: 2009
    ..60 patients with a closed malleolus fracture, treated conservatively using a short leg cast for a period of 6 weeks will be recruited...
  45. Kenneth Paigen; Fiscal Year: 2014
    ..m. domesticus strain C57BL/6J (B6) and the M. m. castaneus strain CAST/EiJ (CAST) by: (a) applying a new, considerably improved, quantitative assay system that measures hotspot ..
  46. Hong Zhu; Fiscal Year: 2016
    ..Since neck muscles receive inputs from both the canals and the otoliths, our results cast doubt on the current interpretation of VEMP testing, and call into question which vestibular organs are responsible ..
  47. Petko M Petkov; Fiscal Year: 2015
    ..background combining knockin alleles of the recombination positioning gene Prdm9 created for this study with CAST or PWD sequences on Chr1...
  48. NXF Proteins, Cofactors and Targets
    Marie Louise Hammarskjold; Fiscal Year: 2012
    ..However, data from several recent studies, including our own, cast some doubts on this model...
  49. TOMAS ALBERTO PROLLA; Fiscal Year: 2016
    ..b>CAST+ahl and CBA/J...
  50. Promoting Treatment Adherence in Adolescent Leukemia
    Dennis D Drotar; Fiscal Year: 2012
    ..key components derived from theory and research on adherence to treatment with pediatric chronic illnesses and cast within the developmental context of families with adolescent children...
  51. David A Agard; Fiscal Year: 2016
    ..2) Mechanism of Spc110/72 facilitated assembly of ?TuSC rings and regulation by phosphorylation: We know that Spc110 stabilizes formation ..
  52. Generation of Synthetic Human Islet Microorgans
    ALFRED LM BOTHWELL; Fiscal Year: 2010
    ..conditions for formation of a human microvascular bed derived from human endothelial cells (EC) that are cast in collagen/fibronectin gels and then implanted into SCID mice...
  53. Fanxin Long; Fiscal Year: 2016
    ..This study therefore has cast uncertainty about the physiological relevance of direct Wnt signaling in bone...
  54. CAST Intervention for Reducing Adolescent Risk Behaviors
    Elaine A Thompson; Fiscal Year: 2010
    ..Coping And Support Training (CAST) is a 12-session, small group prevention program that incorporates a parent component with a subsequent family ..
  55. NEVIN ALAN LAMBERT; Fiscal Year: 2016
    ..Recent work has, however, cast doubt on the generality of collision coupling...
  56. Jimmy Kuang Hsien Hu; Fiscal Year: 2015
    ..These values will be used to cast hydrogels with different stiffness, on which freshly harvested wild type or YAP/TAZ mutant incisor stem cells will ..
  57. Vineet Arora; Fiscal Year: 2016
    ..While peer pressure is often cast as a negative phenomenon among teens, the use of positive peer pressure to change behavior among teens is gaining ..
  58. 2012 Auditory System Gordon Research Conference &Gordon Research Seminar
    DAN HARVEY SANES; Fiscal Year: 2012
    ..keep this conference fresh and relevant is our commitment to explore novel themes, and to gather a completely new cast of speakers, for each successive meeting...
  59. Communities and Schools Together for Childhood Obesity Prevention
    Deborah Johnson-Shelton; Fiscal Year: 2012
    ..The Communities and Schools Together (CAST) study seeks to build a collaborative school-community partnership to discover researched solutions to local ..
  60. Systems Genetics Resource Consortium
    David W Threadgill; Fiscal Year: 2011
    ..combines the genomes of eight genetically diverse founder strains - A/J, C57BL/6J, 12981/SvlmJ, NOD/LtJ, NZO/HILU, CAST/EiJ, PWK/PhJ, and WSB/EiJ - to capture almost 90%of the known variation present in laboratory mice...
  61. Richard D Stevenson; Fiscal Year: 2016
    ..0 hrs/day for 21 days versus 1.5 hrs/day for 21 days) under 2 distinct constraint conditions (Full-time cast versus Part-time splint)...
  62. CISNET: The "Spectrum" of Breast Cancer Disparities
    Jeanne Mandelblatt; Fiscal Year: 2010
    ..White women increasing from 1.27 in 1984 to 1.85 in 1999. This racial inequality in breast cancer outcomes is cast on the backdrop of an obesity epidemic...
    PAUL BUREK; Fiscal Year: 2000
    ..In other words, TCCs are clinically-effective, but not cost-effective. RBDC proposes to develop the Fast Cast (FC)- a reusable, easy-to-apply, adjust and remove, ulcer healing system with the efficacy of TCC's...
  64. Dental Cast Titanium-Ceramic Bonding
    Zhuo Cai; Fiscal Year: 2003
    ..Because of its active nature, melted titanium reacts with investment materials to form a reaction structure on the cast titanium surface, which prevents strong titanium-ceramic bonding...
  65. Genetics of Sagg: A Heritable Mouse Model for Cutis Laxa
    Paul Christner; Fiscal Year: 2004
    ..In Specific Alm I we will obtain Sagg N2 mice from an intersubspecific backcross of (1231-1/140Sagg/+ x CAST/ei)Fl x CAST/ci and construct a fine-map of the recombination events between the molecular markers, DIMU232 and ..
  66. Novel Freeze-Cast Bioactive Glass Scaffolds for Bone Repair
    MOHAMED RAHAMAN; Fiscal Year: 2009
    ..The repair and regeneration of large defects in load-bearing bones require the design and development of porous implants having the right combination of mechanical, structural, and biological characteristics. ..
  67. International Conference on Occupational Voice Research
    John Nix; Fiscal Year: 2007
    ..Conference proceedings will be disseminated through a live web cast of the conference and through a website which will feature text versions of abstracts, streaming videos of ..
  68. Diabetic Foot Ulcer Healing by Load Relieving Dressings
    Joseph Loomis; Fiscal Year: 2006
    ..Usual care" heals typically only about 30% of ulcers in 20 weeks, yet a total contact cast (TCC) can heal > 90% of ulcers in an average of 8 weeks...
  69. Rapid, Universal, Low Cost Automated Genomic DNA Purification from Micro Samples
    WILLIAM MACCONNELL; Fiscal Year: 2009
    ..separation of genomic DNA from total cell lysate in a sampleprocessing cassette that has sections of agarose cast on either side of sample loading wells...
    Vernon Reinhold; Fiscal Year: 2003
    This proposal describes three interrelated Core activities (Proteomics, Bioinformatics, Outreach) that have been cast bo build a multi- disciplinary research team to address the next, more challenging phase of genomics, how gene products ..
    William Dement; Fiscal Year: 2002
    ..stimulant interactions with sleep homeostasis in mice with null mutations of the dopamine transporter allele and in Cast/Ei mice...