ERbeta

Summary

Gene Symbol: ERbeta
Description: estrogen receptor 2
Alias: ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, estrogen receptor beta, ER beta, estrogen receptor beta 4, nuclear receptor subfamily 3 group A member 2
Species: human

Top Publications

  1. pmc Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Nucleic Acids Res 26:3505-12. 1998
  2. pmc A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA
    M Watanabe
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0033, Japan
    EMBO J 20:1341-52. 2001
  3. ncbi Differential expression of two estrogen receptor beta isoforms in the human fetal testis during the second trimester of pregnancy
    Terri L Gaskell
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:424-32. 2003
  4. ncbi Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures
    Andrew J Li
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 189:22-7. 2003
  5. doi Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, 93053, Regensburg, Germany
    Breast Cancer Res Treat 120:557-65. 2010
  6. ncbi Selective loss of estrogen receptor beta in malignant human colon
    E F Foley
    Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22906, USA
    Cancer Res 60:245-8. 2000
  7. ncbi Estrogen receptor beta gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women
    H H L Lau
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, PRC
    Bone 31:276-81. 2002
  8. pmc Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells
    Ana M Covaleda Sotoca
    Toxicology Section, Wageningen University, Tuinlaan 5, 6703 HE, Wageningen, The Netherlands
    Toxicol Sci 105:303-11. 2008
  9. ncbi Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)
    W Seol
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Endocrinol 12:1551-7. 1998
  10. pmc Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity
    Karolina Lindberg
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Blickagången 6, S 141 83 Huddinge, Sweden
    Breast Cancer Res 13:R43. 2011

Research Grants

  1. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
  2. Michael J Soares; Fiscal Year: 2014
  3. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
  4. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
  5. Effects of Estradiol &Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2013
  6. Estrogen and Memory: Genetic Variation and Neuroimaging
    Susan K Conroy; Fiscal Year: 2013
  7. CECILIA MARIE WILLIAMS; Fiscal Year: 2015
  8. ETHAN SAMUEL BURSTEIN; Fiscal Year: 2014
  9. Estrogen Receptor-beta phytoSERMs for Management of Menopause and Memory Decline
    Lon S Schneider; Fiscal Year: 2012
  10. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005

Detail Information

Publications313 found, 100 shown here

  1. pmc Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    S Ogawa
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Nucleic Acids Res 26:3505-12. 1998
    ..Biochemical analysis reveals that the average dissociation constants ( K d) of ERalpha and ERbeta for 17beta-estradiol (E2) are 0.2 and 0.6 nM respectively, but ERbetacx has no ligand binding ability...
  2. pmc A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA
    M Watanabe
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0033, Japan
    EMBO J 20:1341-52. 2001
    ..These findings indicate that p72/p68 acts as an ER subtype-selective coactivator through ER alpha AF-1 by associating with the coactivator complex to bind its AF-2 through direct binding with SRA and the SRC-1/TIF2 family proteins...
  3. ncbi Differential expression of two estrogen receptor beta isoforms in the human fetal testis during the second trimester of pregnancy
    Terri L Gaskell
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:424-32. 2003
    ..we used RT-PCR and immunohistochemistry to examine the pattern of expression of estrogen receptors (ER alpha, ER beta, and ER beta 2 variant) in human fetal testes at 12-19 wk gestation...
  4. ncbi Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures
    Andrew J Li
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 189:22-7. 2003
    ..Epidemiologic data suggest that the malignant transformation of ovarian epithelium may be linked to altered steroid hormone homeostasis...
  5. doi Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, 93053, Regensburg, Germany
    Breast Cancer Res Treat 120:557-65. 2010
    b>Estrogen receptor beta (ERbeta) is widely expressed in mammary epithelium. ERbeta expression is reported to decline during carcinogenesis of the breast and other tissues...
  6. ncbi Selective loss of estrogen receptor beta in malignant human colon
    E F Foley
    Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22906, USA
    Cancer Res 60:245-8. 2000
    ..Malignant transformation of the colon is associated with a marked diminution of ER-beta protein expression, possibly through a posttranscriptional mechanism...
  7. ncbi Estrogen receptor beta gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women
    H H L Lau
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, PRC
    Bone 31:276-81. 2002
    ..between dinucleotide (cytosine-adenine; CA) repeat polymorphisms located in the flanking region of the estrogen receptor beta gene and bone mineral density (BMD) in 325 healthy southern Chinese women...
  8. pmc Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells
    Ana M Covaleda Sotoca
    Toxicology Section, Wageningen University, Tuinlaan 5, 6703 HE, Wageningen, The Netherlands
    Toxicol Sci 105:303-11. 2008
    Breast cancer cells show overexpression of estrogen receptor (ER) alpha relative to ERbeta compared to normal breast tissues. This observation has lead to the hypothesis that ERbeta may modulate the proliferative effect of ERalpha...
  9. ncbi Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)
    W Seol
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Endocrinol 12:1551-7. 1998
    ..In contrast, SHP interacts with ERbeta independent of ligand and reduces its ability to activate transcription by only 50%...
  10. pmc Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity
    Karolina Lindberg
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Blickagången 6, S 141 83 Huddinge, Sweden
    Breast Cancer Res 13:R43. 2011
    ..The mechanisms behind this observation remain largely uncharacterized. In the present study, we investigated whether ERβ can modulate pathways implicated in endocrine resistance development...
  11. ncbi Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization
    Signe Altmäe
    Department of Biotechnology, Institute of Molecular and Cell Biology, Estonian Genome Project, University of Tartu, Estonia, and Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Mol Hum Reprod 13:521-6. 2007
    ..These data suggest the variations in ESR1 gene, in addition to the age of a woman, may predict the COH outcome in IVF...
  12. ncbi Differential expression of the estrogen receptor beta (ERbeta) in human prostate tissue, premalignant changes, and in primary, metastatic, and recurrent prostatic adenocarcinoma
    Thomas Fixemer
    Institute of Pathology, University of the Saarland, Homburg Saar, Germany
    Prostate 54:79-87. 2003
    Estrogen signaling mediated by the estrogen receptor beta (ERbeta) has potential implications in normal and abnormal prostate growth...
  13. ncbi Estrogen receptor alpha and beta polymorphisms: is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy?
    Sandra Silvestri
    Department of Internal Medicine, School of Medicine, University of Florence, Florence, Italy
    Menopause 13:451-61. 2006
    ..In another untreated subpopulation of 443 women, genotype influence on the prevalence of vertebral fractures and on annual rate of bone loss during a mean follow-up period of 11 years was estimated...
  14. ncbi Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer
    A Tsezou
    Laboratory of Cytogenetics and Molecular Genetics, Medical School, University of Thessalia, University Hospital of Larissa, Larissa, Greece
    Breast 17:159-66. 2008
    ..In conclusion, an association for breast cancer risk between short (SS) alleles for the repeat variants of the ESR2 and AR genes was found in women of Greek descent...
  15. pmc Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
    A Migliaccio
    Istituto di Patologia Generale e Oncologia, Facolta di Medicina e Chirurgia, II Universita di Napoli, Largo S Aniello a Caponapoli 2, 80138 Napoli, Italy
    EMBO J 19:5406-17. 2000
    ..The role of this phosphotyrosine is stressed by its requirement for association of oestradiol receptor alpha with Src and consequent activation of Src in intact Cos cells...
  16. pmc Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation
    Maria G Raso
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 15:5359-68. 2009
    ....
  17. doi Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells
    Karolina Lindberg
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Stockholm, Sweden
    J Cell Physiol 222:156-67. 2010
    Estrogen effects on mammary gland development and differentiation are mediated by two receptors (ERalpha and ERbeta)...
  18. ncbi Role of estrogen receptors alpha, beta and GPER1/GPR30 in pancreatic beta-cells
    Angel Nadal
    CIBER de Diabetes y Enfermedades Metabolicas Asociadas and Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Elche, Spain
    Front Biosci (Landmark Ed) 16:251-60. 2011
    ..In this respect, ERalpha is directly implicated in the E2-regulation of insulin content and secretion, while ERbeta is in the E2-potentiation of glucose-induced insulin release...
  19. ncbi Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern
    E Enmark
    Center for Biotechnology, Novum, Huddinge, Sweden
    J Clin Endocrinol Metab 82:4258-65. 1997
    ..The finding of a second subtype of ER (ER beta) has caused considerable excitement amongst endocrinologists...
  20. ncbi The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
    J M Hall
    Department of Pharmacology and Cancer Biology, Duke University, Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 140:5566-78. 1999
    The human estrogen receptor alpha (ERalpha) and the recently identified ERbeta share a high degree of amino acid homology; however, there are significant differences in regions of these receptors that would be expected to influence ..
  21. ncbi An activator protein 1-like motif mediates 17beta-estradiol repression of gonadotropin-releasing hormone receptor promoter via an estrogen receptor alpha-dependent mechanism in ovarian and breast cancer cells
    Chi Keung Cheng
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada V6H 3V5
    Mol Endocrinol 17:2613-29. 2003
    ..Taken together, our data indicate that E2-activated estrogen receptor-alpha represses human GnRHR gene transcription via an indirect mechanism involving CBP and possibly other transcriptional regulators...
  22. ncbi Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors
    Fabio Stossi
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 145:3473-86. 2004
    ..exert many important effects in bone, a tissue that contains both estrogen receptors alpha and beta (ERalpha and ERbeta)...
  23. ncbi Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells
    Layton Harris Smith
    Department of Medicine, Vanderbilt University Medical Center and Nashville Veterans Affairs Medical Center, Nashville, Tenn 37232 6300, USA
    Circ Res 95:269-75. 2004
    ..gene expression in vascular cells, we compared the transactivation properties of estrogen receptors (ERalpha and ERbeta) in regulating the activity of a human PAI-1 promoter reporter construct in transfected bovine aortic endothelial ..
  24. ncbi Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter
    Moisés García-Arencibia
    Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University, 28040 Madrid, Spain
    J Steroid Biochem Mol Biol 94:1-14. 2005
    ..using nuclear extracts of E(2)-treated cells and natural sequences, including these putative EREs, indicated that ERbeta - the only isoform expressed in U-937 cells - specifically recognized both EREs because ERbeta-DNA complexes were ..
  25. ncbi Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters
    M Wang
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China
    Eur J Surg Oncol 33:195-201. 2007
    We aimed to investigate the sources of estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta) and estimate the value of both ER subtypes in gastric adenocarcinoma and analyze the possible relationship of prothymosin alpha (..
  26. pmc Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance
    Grazia Arpino
    Dan L Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Endocr Rev 29:217-33. 2008
    ....
  27. doi Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis
    T Harsløf
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Calcif Tissue Int 87:25-35. 2010
    ..We confirm that genetic variants in ESR1 and ESR2, but not RIZ1, are important in osteoporosis. We found no evidence of interaction between polymorphisms, but we found that the effects of genetic variants in ESR1 might be sex dependent...
  28. ncbi Estrogen receptor beta variants mRNA expressions in gastric cancer tissues and association with clinicopathologic parameters
    J L Guo
    Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
    Hepatogastroenterology 57:1584-8. 2010
    The aim of this study is to examine the expression of estrogen receptor beta-1, 2 ,5 in gastric cancer tissues and evaluate their correlation with clinicopathological features.
  29. doi Cytoplasmic estrogen receptor β as a potential marker in human non-small cell lung carcinoma
    Mohit Kumar Verma
    Tohoku University Graduate School of Medicine, Department of Pathology, 2 1 Seriyo machi, Aoba ku, Sendai, Miyagi ken 980 8575, Japan
    Expert Opin Ther Targets 16:S91-102. 2012
    ..Estrogen has been reported to promote an increased susceptibility to lung cancer development. This study focusses on the role of cytoplasmic estrogen receptor β (c-ERβ) in NSCLC...
  30. doi Expression of estrogen receptor β1 in colorectal cancer: correlation with clinicopathological variables
    Lea Rath-Wolfson
    Department of Pathology, Hasharon Hospital, Petah Tikva, Israel
    Oncol Rep 27:2017-22. 2012
    ..the non-metastatic ones. Our data suggest that there is an estrogen influence on the development and progression of colon cancer. Furthermore, it was found to be higher in the more severe cases...
  31. pmc Estrogen receptor beta binds Sp1 and recruits a corepressor complex to the estrogen receptor alpha gene promoter
    V Bartella
    Department of Pharmaco Biology, University of Calabria, Via P Bucci, 87036 Arcavacata di Rende, CS, Italy
    Breast Cancer Res Treat 134:569-81. 2012
    ..Normal breast tissues display a relative higher expression of ER beta than ER alpha, which drastically changes during breast tumorogenesis...
  32. ncbi Combined profile of the tandem repeats CAG, TA and CA of the androgen and estrogen receptor genes in breast cancer
    Andrei Anghel
    Department of Biochemistry, Victor Babes University of Medicine and Pharmacy of Timisoara, 2, Eftimie Murgu Square, 300041, Timisoara, Romania
    J Cancer Res Clin Oncol 132:727-33. 2006
    ..While several studies investigated the association between the androgen receptor (AR) gene, CAG repeat and breast cancer, for the CA and TA repeats in the ER genes there are considerably fewer studies (one for CA and none for TA)...
  33. pmc ER-β mediates 17β-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling
    Sheila M Adams
    Department of Psychology, Program in Behavioral Neuroscience, University of South Carolina, Columbia, South Carolina 29208, USA
    Synapse 64:829-38. 2010
    ..Our data suggest that estrogen intervenes against HIV-1 Tat-induced cortical neuronal dysfunction via intersecting mitochondrial apoptotic pathway signaling in an ER-sensitive manner...
  34. doi Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis
    Merit Lamp
    Department of Obstetrics and Gynaecology, University of Tartu, Tartu, Estonia
    Gynecol Endocrinol 27:425-33. 2011
    ..To investigate whether polymorphisms in genes involved in biosynthesis and signalling of sex steroids influence susceptibility to endometriosis and to infertility associated with it...
  35. ncbi Estrogen receptor-beta mRNA variants in human and murine tissues
    B Lu
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    Mol Cell Endocrinol 138:199-203. 1998
    ..Interestingly, no equivalent of the mouse inserted transcript was detected in any of the four human tissues analyzed...
  36. ncbi Association between estrogen receptor-beta gene polymorphisms and ovulatory dysfunctions in patients with menstrual disorders
    C Sundarrajan
    Department of Obstetrics and Gynecology, National University of Singapore, National University Hospital, Singapore 119074
    J Clin Endocrinol Metab 86:135-9. 2001
    ..hormone exerts its physiological responses through the estrogen receptor (ER), of which two subtypes, ERalpha and ERbeta, are known...
  37. ncbi Investigations of a CA repeat in the oestrogen receptor beta gene in patients with Alzheimer's disease
    C Forsell
    Department of Geriatric Medicine, Karolinska Institutet, Neurotec, Novum, KFC, S 141 86 Stockholm, Sweden
    Eur J Hum Genet 9:802-4. 2001
    ..Recently a new oestrogen receptor was identified, oestrogen receptor beta (ERbeta), located at chromosome 14q22-24...
  38. ncbi Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women
    Lars Westberg
    Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Clin Endocrinol (Oxf) 61:216-23. 2004
    ..present study was undertaken in order to investigate the possible influence of polymorphisms of the genes encoding the oestrogen receptor (ER)alpha, ERbeta and the progesterone receptor (PGR), on prolactin levels in premenopausal women.
  39. ncbi ERbeta sensitizes breast cancer cells to retinoic acid: evidence of transcriptional crosstalk
    Caroline Rousseau
    Department of Oncology, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Mol Cancer Res 2:523-31. 2004
    ..The discovery of ERbeta, also present in breast cancer cells, has added a new level of complexity to this malignancy...
  40. ncbi Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours
    Anna Batistatou
    Department of Pathology, University of Ioannina, Medical School, 451 10, Ioannina, Greece
    J Neurooncol 77:17-23. 2006
    b>Estrogen receptor beta (ERbeta) is an important mediator of estrogen function in a variety of tissues. Its expression declines in breast, ovarian, prostatic and colon carcinomas as well as in astrocytic tumours...
  41. ncbi Biological role of estrogen receptor beta in salivary gland adenocarcinoma cells
    Kazufumi Ohshiro
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5994-9. 2006
    This study is intended to investigate the biological role of estrogen receptor (ER) nongenomic signaling in salivary gland adenocarcinoma cells that predominantly express ERbeta.
  42. pmc Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-α and -β via the IGF-1 and the insulin receptors in breast cancer cells
    A E Richardson
    School of Medicine, Center for Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Growth Factors 29:82-93. 2011
    ..This novel mechanism of IGF-2 synergistic cross-talk signaling with ER-α and ER-β can promote estrogen-independent BC progression and provide new therapeutic targets for the treatment of BC patients...
  43. ncbi Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha
    Serban P Georgescu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Endocrinol 19:2491-501. 2005
    ..Vascular cells express the two known estrogen receptors (ERs), ERalpha and ERbeta, ligand-activated transcription factors that regulate gene transcription through interactions with both ..
  44. pmc Estrogen receptor 1 gene (ESR1) is associated with restrictive anorexia nervosa
    Audrey Versini
    INSERM U894 Team 1, Center of Psychiatry and Neurosciences, University Paris Descartes, 2ter rue d Alesia, Paris, France
    Neuropsychopharmacology 35:1818-25. 2010
    ..In particular, ESR1 gene confers a high risk of vulnerability to the restrictive subtype of AN, and suggests that the estrogen pathway has to be further analyzed in AN...
  45. ncbi Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway
    Saveria Aquila
    Centro Sanitario, University of Calabria 87030 Arcavacata di Rende, Cosenza, Italy
    J Clin Endocrinol Metab 89:1443-51. 2004
    ..a rapid nongenomic way, are mediated by a single estrogen receptor (ER) or by the two ER subtypes, ER alpha and ER beta. In the present study, we have first demonstrated the concomitant expression of ER beta and ER alpha in human ..
  46. ncbi Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer
    Paula Maguire
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Breast Cancer Res Treat 94:145-52. 2005
    ..through binding to the estrogen receptors, estrogen receptor alpha (ESR1) and the more recently discovered estrogen receptor beta (ESR2)...
  47. pmc Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta
    Nathalie Picard
    Research Center, Ste Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec, Canada
    Mol Endocrinol 22:317-30. 2008
    ..recognized as an important regulator in the hormonal response by estrogen receptor (ER) alpha, but its impact on ERbeta function is poorly characterized...
  48. ncbi Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta
    A Tremblay
    Ste Justine Hospital Research Center, University of Montreal, Montreal, QC, Canada H3T 1C5
    J Steroid Biochem Mol Biol 77:19-27. 2001
    ..The estrogenic signal is now known to be transduced by two estrogen receptors, ERalpha and ERbeta. Hormone-dependent transcriptional activation of ER and other nuclear receptors involves assembly of a ..
  49. pmc Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels
    Inga Peter
    Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2779-85. 2008
    ..To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels...
  50. ncbi Functional analysis of transcriptional activity of cytosine and adenine (CA) repeats polymorphism in the estrogen receptor beta gene
    Kanako Ugai
    J Toxicol Sci 33:237-40. 2008
    ..and adenine" nucleotide motifs is one of the genomic microsatellites in intron 5 of the estrogen receptor beta (ER beta) gene (14q22-24). Relations between CA repeats polymorphism and several diseases have been shown...
  51. ncbi Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors
    Dong Ju Jung
    Department of Life Science, Pohang University of Science and Technology, Pohang 790 784, Korea
    J Biol Chem 277:1229-34. 2002
    ..factors we tested, the AP-1 component c-Jun and the estradiol-bound ligand binding domains of ERalpha and ERbeta. Interestingly, CAPER exhibited a cryptic autonomous transactivation function that becomes activated only in the ..
  52. ncbi A negative coregulator for the human ER
    John D Norris
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 16:459-68. 2002
    ..These findings suggest a role for RNA binding proteins as coregulatory factors of the nuclear receptor family and reveal a novel mechanism by which antiestrogens can manifest agonist activities in some tissues...
  53. ncbi Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer
    Fergal J Fleming
    Department of Surgery, St Vincent s University Hospital, Dublin 4, Ireland
    J Clin Endocrinol Metab 89:375-83. 2004
    ..Differential recruitment of SRC-1 and SMRT by ER-alpha and ER-beta in the presence of beta-estradiol and 4-OHT may be central to the response of the tumor to endocrine treatment...
  54. ncbi Evaluation of mRNA expression of estrogen receptor beta and its isoforms in human normal and neoplastic endometrium
    Maciej Skrzypczak
    Second Department of Gynecology, Prof F Skubiszewski University School of Medicine, Jaczewskiego 8 St, 20 090 Lublin, Poland
    Int J Cancer 110:783-7. 2004
    Endometrial cancer is well known to be estrogen-dependent. Two estrogen receptor types, ERalpha and ERbeta, are major mediators of a diversity of biologic functions of estrogen and play an important role in estrogen-dependent tissues and ..
  55. pmc Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways
    Xiaodong Li
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Mol Cell Biol 24:7681-94. 2004
    The effects of estrogens, particularly 17beta-estradiol (E2), are mediated by estrogen receptor alpha (ERalpha) and ERbeta. Upon binding to E2, ERs homo- and heterodimerize when coexpressed...
  56. ncbi Estrogen receptor beta (ER beta) level but not its ER beta cx variant helps to predict tamoxifen resistance in breast cancer
    Majida Esslimani-Sahla
    Endocrinologie moléculaire et cellulaire des cancers U 540, Institut National de la Sante et de la Recherche Medicale INSERM, Montpellier, France
    Clin Cancer Res 10:5769-76. 2004
    ..The expression of total ER beta protein, and of ER beta cx protein, was estimated anonymously in formalin-fixed, paraffin-embedded tumor sections,..
  57. ncbi Frequent loss of estrogen and progesterone receptors in human prostatic tumors determined by quantitative real-time PCR
    Qing Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Mol Cell Endocrinol 229:103-10. 2005
    Relative gene expression of the estrogen receptors (ER)-alpha (NR3A1) and ER-beta (NR3A2) along with progesterone receptors PR-A and PR-B (NR3C3) was determined by quantitative real-time PCR in a previously characterized panel of paired ..
  58. ncbi Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 1601C Guggenheim, 200 1st Street Southwest, Rochester, Minnesota 55905, USA
    Mol Endocrinol 19:1555-68. 2005
    The 17beta-estradiol (E2) receptor isoforms [estrogen receptor (ER) alpha and ERbeta] bind E2 and selective ER modulators (SERMs) as homodimers (alpha/alpha or beta/beta) or heterodimers (alpha/beta) to regulate gene expression...
  59. ncbi Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:28596-604. 2006
    ..ER-specific regulation, we used microarray and reverse transcription-PCR analyses of E2-treated U2OS-ERalpha or -ERbeta cells and identified retinoblastoma-binding protein 1 (RBBP1) as a major E2-regulated gene...
  60. ncbi Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the Study of Women's Health Across the Nation (SWAN)
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S61-8. 2006
    ..potential associations between single nucleotide polymorphism (SNP) variants in estrogen receptor (ERalpha and ERbeta) genes, high-density lipoprotein (HDL) cholesterol, and apolipoprotein A-1 (apoA-1) concentrations in women of 4 ..
  61. ncbi The association of bone mineral density with estrogen receptor gene polymorphisms
    Gail A Greendale
    Division of Geriatrics, David Geffen School of Medicine at the University of California Los Angeles, California 90095 1687, USA
    Am J Med 119:S79-86. 2006
    ..Among these, ESR2 rs1256030 and ESR2 rs1256065 appear to have an effect at both the lumbar spine and hip in Chinese women and may warrant further study...
  62. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..tagging SNPs in genes along the steroid hormone synthesis, metabolism and binding pathways, including the estrogen receptor beta (ESR2) gene. Four htSNPs tag the 6 major (>5% frequency) haplotypes of the ESR2 gene...
  63. ncbi Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease
    Bartłomiej Kisiel
    Department of Internal Diseases and Rheumatology, Military Institute of Health Services, Postgraduate School of Molecular Medicine, Warsaw, Poland
    Clin Endocrinol (Oxf) 68:429-34. 2008
    ..To investigate whether a polymorphism in the ESR2 gene (rs4986938, previously associated with endometriosis, ovulatory dysfunction and premature onset of coronary heart disease) increases the risk of Graves' disease (GD)...
  64. pmc Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma
    Katarzyna Urbanska
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 219:392-401. 2009
    ..Here we demonstrate for the first time that estrogen receptor beta (ERbeta) can contribute to the development of genomic instability in medulloblastomas...
  65. doi Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome
    Jin Ju Kim
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
    Fertil Steril 93:1942-7. 2010
    ..To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS)...
  66. doi Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Cancer Sci 100:927-33. 2009
    ..21, respectively). We found no remarkable difference for the other four polymorphisms. Our findings suggest that polymorphisms in the estrogen receptor beta gene may modify the association between isoflavone intake and breast cancer risk.
  67. doi Challenging estrogen receptor beta with phosphorylation
    Mélanie Sanchez
    Department of Biochemistry, Ste Justine Hospital Research Center, University of Montreal, Montreal, Quebec, Canada
    Trends Endocrinol Metab 21:104-10. 2010
    ..in reproductive and peripheral target tissues through its interaction with the estrogen receptors ERalpha and ERbeta. However, our knowledge of estrogen-dependent and independent action has mainly focused on ERalpha, leaving the ..
  68. ncbi Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha
    P Pace
    Department of Medical Oncology, Imperial College of Medicine, Charing Cross Campus, St Dunstan s Road, London W6 8RF, United Kingdom
    J Biol Chem 272:25832-8. 1997
    The cloning of a novel estrogen receptor beta (denoted ERbeta) has recently been described (Kuiper, G. G. J. M., Enmark, E., Pelto-Huikko, M., Nilsson, S., and Gustafsson, J-A. (1996) Proc. Natl. Acad. Sci. U. S. A...
  69. ncbi Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression
    Meng Min Liu
    Department of Medicine, University of California, San Francisco, California 94112 1640, USA
    J Biol Chem 277:24353-60. 2002
    ..The action of ERbeta at the cyclin D1 promoter is unknown, although evidence suggests that ERbeta may inhibit the proliferative action ..
  70. ncbi Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 63:7624-9. 2003
    ..DNA samples from the Shanghai Breast Cancer Study, we tested the hypothesis that sequence variants of the estrogen receptor beta gene (ESR2) may be associated with increased risk for breast cancer, particularly among women who have a ..
  71. pmc Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D
    Anders Strom
    Department of Biosciences, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:1566-71. 2004
    ..In agreement with this, we show in this study that induced expression of ERbeta in the breast cancer cell line T47D reduces 17beta-estradiol-stimulated proliferation when expression of ERbeta ..
  72. ncbi Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis
    Jennifer Cheng
    Center for Endocrinology and Molecular Medicine, Northwestern University, 303 East Chicago Avenue, Tarry Building 15 703, Chicago, IL 60611, USA
    FEBS Lett 566:169-72. 2004
    The involvement of estrogen receptor beta (ERbeta) in prostate carcinogenesis has been hypothesized...
  73. ncbi Expression of estrogen receptor-beta isoforms in Barrett's metaplasia, dysplasia and esophageal adenocarcinoma
    Liang Liu
    Department of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, TX 77030, USA
    Anticancer Res 24:2919-24. 2004
    ..that the majority of esophageal adenocarcinomas (EA), and its precursor Barrett's metaplasia (BM), express estrogen receptor beta (ER-B)...
  74. ncbi Endometrial endothelial cell steroid receptor expression and steroid effects on gene expression
    Graciela Krikun
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 90:1812-8. 2005
    ..Thus, quantitative RT-PCR and microarray analyses demonstrate that HEECs express ER-beta and PR mRNA and that gene expression by HEECs is differentially regulated by treatment with estrogen or progestin...
  75. ncbi Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Hypertens 18:1388-95. 2005
    ..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure...
  76. ncbi Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer
    Maria Hedelin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Prostate 66:1512-20. 2006
    ..Because phytoestrogens bind tightly to the estrogen receptor-beta, we conducted an epidemiologic investigation of synergistic effects between phytoestrogen intake and estrogen receptor-beta gene polymorphisms...
  77. ncbi Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
    ..Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture...
  78. pmc Apigenin suppresses cancer cell growth through ERbeta
    Paul Mak
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neoplasia 8:896-904. 2006
    ..In yeast transcription assays, both flavonoids displayed high specificity toward ERbeta transactivation, particularly at lower concentrations...
  79. ncbi Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice
    Nancy L Cho
    Departments of Surgery and Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 67:2366-72. 2007
    ..of E(2) in intestinal tumor inhibition, we separately crossed C57BL/6J-Min/+ (Min/+) mice with Eralpha(+/-) and Erbeta(+/-) mice to generate ER-deficient Min/+ progeny...
  80. pmc Genetic polymorphisms in the estrogen receptor beta (ESR2) gene and the risk of epithelial ovarian carcinoma
    Galina Lurie
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Room 301C, Honolulu, HI 96813, USA
    Cancer Causes Control 20:47-55. 2009
    ..b>Estrogen receptor beta is a predominant estrogen receptor in the normal ovary...
  81. pmc Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy
    Yan Jin
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Oncol 26:5849-54. 2008
    ..We determined whether genetic polymorphisms in estrogen receptors (ESRs) alpha and beta (ESR1 and ESR2, respectively) are associated with tamoxifen-induced hot flashes...
  82. pmc Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study
    Jonathan D Marotti
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 23:197-204. 2010
    ..The role of ER-beta in the development and progression of breast cancers defined by lack of expression of ER-alpha merits further investigation...
  83. pmc Estrogen signaling via estrogen receptor {beta}
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    J Biol Chem 285:39575-9. 2010
    ..We also highlight the recent work establishing new roles of ERβ signaling, including protective functions in the epithelial-mesenchymal transition and in atherosclerosis, as well as regulation of cell proliferation in the colon...
  84. doi Comparative analysis of nuclear estrogen receptor alpha and beta interactomes in breast cancer cells
    Giovanni Nassa
    Department of General Pathology, Second University of Naples, Via L De Crecchio 7, 80138 Napoli, Italy
    Mol Biosyst 7:667-76. 2011
    ..Altogether, these data provide new insights on the protein-protein interaction networks controlled by ER-α and -β that mediate their ability to transduce estrogen signaling in breast cancer cells...
  85. pmc Significance of ERβ expression in different molecular subtypes of breast cancer
    Liying Guo
    Department of Breast, Digestive and Vascular Center, First Affiliated Hospital of Xinjiang Medical University, NO, 137, South Liyushan Road, Xinjiang 830054, P, R, China
    Diagn Pathol 9:20. 2014
    ..This study is to investigate the estrogen receptor β (ERβ) expression in molecular subtypes of breast cancer and clinic significance of ERβ expression...
  86. ncbi ER beta: identification and characterization of a novel human estrogen receptor
    S Mosselman
    N V Organon, Department of Biotechnology and Biochemistry, The Netherlands
    FEBS Lett 392:49-53. 1996
    A novel estrogen receptor (hereinafter referred to as ER beta) was cloned using degenerate PCR primers...
  87. ncbi Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway
    S Kahlert
    Medizinische Poliklinik and the Institut für Physiologie II, University of Bonn, 53111 Bonn, Germany
    J Biol Chem 275:18447-53. 2000
    ..Taken together, these data demonstrate that ligand bound estrogen receptor alpha is required for rapid activation of the IGF-1R signaling cascade...
  88. ncbi The expression of ER beta cx in human breast cancer and the relationship to endocrine therapy and survival
    Carlo Palmieri
    Department of Cancer Medicine, Cancer Cell Biology Group, Cancer Research UK Laboratories, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Clin Cancer Res 10:2421-8. 2004
    ..Currently, there are no ways to predict response to such treatments. ER beta cx, a variant of ER beta, has a dominant-negative effect over ER alpha, and its expression thought to modulate ..
  89. ncbi Association between the estrogen receptor beta gene and age of onset of Parkinson's disease
    L Westberg
    Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Psychoneuroendocrinology 29:993-8. 2004
    The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD)...
  90. ncbi Differential distribution of splice variants of estrogen receptor beta in human testicular cells suggests specific functions in spermatogenesis
    E L Aschim
    Andrology Laboratory, Department of Gynaecology and Obstetrics, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Steroid Biochem Mol Biol 92:97-106. 2004
    A growing number of estrogen receptor beta (ER beta) splice variants are reported. Several of these have been discovered in testis, but with few exceptions little is known about their cellular localization...
  91. ncbi Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells
    L C Murphy
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
    J Mol Endocrinol 34:553-66. 2005
    To investigate the effect of altered oestrogen receptor (ER)alpha and ERbeta expression on oestrogen and anti-oestrogen action in breast cancer, we have stably expressed an inducible ERbeta1 in MCF7 breast cancer cells...
  92. ncbi [Association between single-nucleotide polymorphisms in estrogen receptor beta gene and risk of prostate cancer]
    Ying Hao Sun
    Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Wai Ke Za Zhi 43:948-51. 2005
    This study was undertaken to investigate the relationship of some single nucleotide polymorphisms (SNPs) of estrogen receptor beta (ERbeta) with the risk of prostate cancer (CaP).
  93. ncbi Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis
    P Fytili
    Department of Orthopedics, Medical School, University of Thessaly, Universit Hospital of Larissa, Larissa, Greece
    Clin Genet 68:268-77. 2005
    ..002 and 0.001). An association between c.1092+3607(CA)(13-27) and c.172(CAG)(8-34) repeat polymorphisms of the ER-beta and AR genes and knee OA was found in individuals of Greek descent...
  94. ncbi Estrogen receptors alpha and beta (ERalpha and ERbeta) and androgen receptor (AR) in human sperm: localization of ERbeta and AR in mitochondria of the midpiece
    S Solakidi
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, Laboratory of Molecular Endocrinology, 48 Vas Constantinou Ave, 11635 Athens, Greece
    Hum Reprod 20:3481-7. 2005
    ..has focused attention on the presence and distribution of their cognate receptors [estrogen receptor (ER) alpha, ERbeta and androgen receptor (AR)] in male reproductive tissues and cells...
  95. ncbi Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue
    Steven S Shen
    Department of Pathology, The Methodist Hospital and Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer 106:2610-6. 2006
    ..In a previous study the selective ER modulator raloxifene was shown to induce apoptosis in an ERbeta-positive bladder cancer cell line...
  96. ncbi Estrogen receptor polymorphisms in tamoxifen-treated women with breast cancer
    Neoklis A Georgopoulos
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Patras Medical School, Greece
    Gynecol Endocrinol 22:185-9. 2006
    ..of the estrogen receptor-alpha gene (ERalpha) and RsaI and AluI polymorphisms of the estrogen receptor-beta gene (ERbeta) have been associated with breast cancer...
  97. ncbi Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide
    M Reimann
    Dietary Fibre and the Metabolic Syndrome Group, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Climacteric 9:215-23. 2006
    ..ER) may influence homocysteine and ADMA, yet no information is available on associations with single nucleotide polymorphisms in the estrogen receptor genes ERalpha (PvuII and XbaI) and ERbeta (1730G-->A and cx + 56 G-->A).
  98. pmc Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours
    G P Skliris
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
    Br J Cancer 95:616-26. 2006
    To analyse the phenotype of breast tumours that express oestrogen receptor-beta (ERbeta) alone tissue microarrays were used to investigate if ERbeta isoforms are associated with specific prognostic markers and gene expression phenotypes ..
  99. ncbi A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction
    J Ignacio Aguirre
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, The Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 282:25501-8. 2007
    ..the adaptive response of bone to mechanical forces is defective in mice lacking estrogen receptor (ER) alpha or ERbeta. We report that ERKs are not activated by stretching in osteocytic and osteoblastic cells in which both ERalpha ..
  100. pmc Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women
    Kathryn M Rexrode
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:1749-56. 2007
    ..Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2)...
  101. pmc Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study
    Maria Nilsson
    Departments of Biosciences and Nutrition, Karolinska Institutet, S 141 57 Huddinge, Sweden
    BMC Med Genet 8:73. 2007
    ..In this report we analyse ESR1 and ESR2 gene single nucleotide polymorphisms (SNPs) for association with obesity. We also relate adipose tissue ESR1 mRNA levels and ESR1 SNPs to adipocyte lipolysis and lipogenesis phenotypes...

Research Grants65

  1. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
    ..The expected results will further our understanding of ER2 signaling in the post-menopausal brain by elucidating the precise molecular mechanisms that drive estrogen-independent regulation of ER2 target genes. ..
  2. Michael J Soares; Fiscal Year: 2014
    ..Estradiol binds and signals through estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), while progesterone signals through the progesterone receptor (PGR)...
  3. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..show that androgens can act directly on PVN neurons in the male rat through a novel pathway that involves estrogen receptor beta (ERbeta), whereas E acts predominantly through ERalpha...
  4. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..Furthermore, we will develop a new methodology that will be critical for examining epigenetic changes in gene expression in a temporal and spatial manner in neural tissue with heterogeneous cell populations. ..
  5. Effects of Estradiol &Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2013
    ..during the menopausal transition, and indirect data suggest a potential role for estrogen, particularly estrogen receptor beta, in mediating anxiety...
  6. Estrogen and Memory: Genetic Variation and Neuroimaging
    Susan K Conroy; Fiscal Year: 2013
    ..We will also investigate how changes in estrogen as a result of breast cancer treatment alter brain function, and relate these changes to memory function. ..
  7. CECILIA MARIE WILLIAMS; Fiscal Year: 2015
    ..b>Estrogen receptor beta (ER[unreadable]) is the predominant estrogen receptor in the human colonic epithelium;polymorphisms in ..
  8. ETHAN SAMUEL BURSTEIN; Fiscal Year: 2014
    ..Acadia Pharmaceuticals has discovered highly selective estrogen receptor beta (ER[unreadable])-agonists that are highly efficacious in animal models of neuropathic pain...
  9. Estrogen Receptor-beta phytoSERMs for Management of Menopause and Memory Decline
    Lon S Schneider; Fiscal Year: 2012
    ..We have developed a formulation of phytoestrogenic molecules, that we term PhytoSERMs, which targets estrogen receptor beta. This study will determine the best dose, safety and tolerance of PhytoSERMs in peri to menopausal women ..
  10. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005
    ..of rhesus monkeys in vivo to further test, and develop toward approval as a drug for human use, a novel estrogen receptor beta (ERbeta or ERb) selective (over ERalpha or ERa) agonist that is hypothesized to be effective for ..
  11. Interferon and Raloxifene Effects on Cancer Cells
    CHERYL ROSENFELD; Fiscal Year: 2007
    ..this proposal is that Type I IFN transcriptionally up-regulate the activity of the estrogen receptor-beta (ERbeta) gene in endometrium, which in turn modulates the concentration of the estrogen receptor-alpha (ERa)...
  12. GENE ACTIVATION BY ANTIESTROGENS USED IN CANCER THERAPY
    Peter Kushner; Fiscal Year: 2007
    ..the biochemical mechanisms and physiological significance of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) activation of gene expression at target genes with AP-1 or CRE sites (AP-1/CRE)...
  13. ER beta selective agonist coronary protection--menopause
    R Hermsmeyer; Fiscal Year: 2003
    ..I project is to test and develop, using primate coronary artery vascular muscle cells in vitro, a novel estrogen receptor beta (ERbeta) selective (over ERalpha) agonist that is highly effective for protecting coronary arteries ..
  14. Catherine S Woolley; Fiscal Year: 2016
    ..We will approach this goal by defining cellular mechanisms of acute, estrogen receptor beta (ERbeta)-dependent regulation of synapses in the hippocampus of adult male and female rats...
  15. Regulation of the Tryptophan Hydroxylase-2 Promoter by Estrogen
    Ryoko Hiroi; Fiscal Year: 2013
    ..E2- induced increases of TpH2 mRNA are mediated via estrogen receptor beta (ER2), and activation of local ER2 in the DRN is sufficient for this increase in TpH2 mRNA and for ..
  16. Effects of smoking on ERb and AHR pathway in human lung
    Radoslav Goldman; Fiscal Year: 2004
    ..Recently, estrogen receptor beta (ERb) was discovered to be expressed in human lung tissue and possibly absent in cancerous tissue...
  17. CYNTHIA LOUISE BETHEA; Fiscal Year: 2014
    ..We hypothesize that serotonin neurons in male primates express estrogen receptor beta (ER[unreadable]) and androgen receptors (AR) and that the balance of activity at these receptors governs ..
  18. Nuclear IRS-1-DNA repair and mutagenesis in medulloblastoma
    Krzysztof Reiss; Fiscal Year: 2012
    ..In this respect, estrogen receptor beta (ER[unreadable]), which is highly expressed in medulloblastomas, can translocate IRS-1 to the nucleus in ..
  19. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
    ..It circulates at high levels, and is concentrated in the prostate. Moreover, equol can selectively bind estrogen receptor beta to activate an anti-proliferative cascade in prostate...
  20. Asim B Abdel-Mageed; Fiscal Year: 2015
    ..Our hypothesis will be tested by the following specific aims: (1) to evaluate the clinical utility of SAFB2 and ERb expression levels as biomarkers and/or prognostic indicators of aggressive PC in African Americans...
  21. Estrogen receptor beta protein:protein interactions following estrogen withdrawal
    NATASHA MOTT; Fiscal Year: 2013
    ..Overall, this proposal will reveal molecular mechanisms occurring during estrogen withdrawal that may alter the brain's receptivity to HT. ..
  22. Estrogen Receptor Beta Regulation of Mandibular Condylar Growth
    Sunil Wadhwa; Fiscal Year: 2013
    ..inhibition of mechanical loading-induced periosteal bone formation and axial skeletal growth requires estrogen receptor beta (ER[unreadable])...
  23. The Efficacy and Safety of a Selective Estrogen Receptor Beta agonist (LY500307)
    Alan Breier; Fiscal Year: 2013
    ..Selective Estrogen Receptor Beta (ER beta) agonists are a new class of treatments that are relatively free of estrogen's primary side ..
  24. The Role of Estrogen Receptor-Beta on Human Fetoplacental Vasculature
    Emily J Su; Fiscal Year: 2012
    ....
  25. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  26. Soy Consumption and Breast Tissue Proliferation
    Gertraud Maskarinec; Fiscal Year: 2006
    ..Explore the role of estrogen receptor Beta in the response of normal and cancerous breast tissue to soy intake...
  27. Estrogen Receptor Beta Regulation of the GnRH Neuron
    JENNIFER MAMMEN; Fiscal Year: 2009
    ..The goal of this research is to study the regulatory effects of estrogen, as mediated by estrogen receptor beta (ERbeta) in GnRH neurons, where this is the predominant isoform...
  28. ESTROGEN RECEPTOR-BETA PROTEIN IN CANCER DIAGNOSIS
    ROBERT CHRISTY; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATION: The production of monoclonal antibodies against the Estrogen Receptor Beta isoforms will provide researchers and clinicians important reagents to determine the mechanisms of action ..
  29. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..There are two ER subtypes, ERa and ERb. Studies indicate that the beneficial effect of estrogens on fat accumulation is mediated by ERa...
  30. T Rajendra Kumar; Fiscal Year: 2016
    ..The proposed research is significant because it is expected to vertically advance and expand understanding of how chemopreventive agents targeted to block estrogen and hedgehog signaling regulate gonadotrope/null cell adenomas. ..
  31. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ....
  32. DongBao Chen; Fiscal Year: 2016
    ..Aim 1: to determine the proximal membrane ER signaling events (G-protein activation) and if ERa and ERb play different roles in G-protein activation and eNOS-NO production and ERK2/1 pathway on estrogen stimulation...
  33. Suranganie F Dharmawardhane; Fiscal Year: 2016
    ..by soy isoflavones in metastatic breast cancer cell lines that do not express estrogen receptors (ER), only ER beta or both ER isoforms...
  34. VASCULAR ESTROGEN RECEPTORS--MOLECULAR MECHANISMS
    Michael Mendelsohn; Fiscal Year: 2001
    ..Very recently, a second estrogen receptor, ERb, was discovered in rat prostate...
  35. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..The current proposal is focusing on determining androgen downstream target genes and subsequent signaling network during the process of inguinoscrotal testis descent, which may provide new insight into the causes of testis maldescent. ..
  36. Estrogen Metabolism and Action in Prostate Cancer Etiology in PCPT
    Ashraful Hoque; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. ROLE OF ALPHA & BETA ESTROGEN RECEPTORS IN AGGRESSION
    Sonoko Ogawa; Fiscal Year: 2003
    ..The findings of the proposed studies will provide new insights concerning the specific roles and mechanisms played by the two types of ERs in the sex-specific regulation of aggressive behavior by gonadal steroids. ..
  38. Estrogen Receptor-beta and Prostate Function
    Shuk Mei Ho; Fiscal Year: 2004
    ..They will also identify new ER-beta/antiestrogen regulating genes and illuminate potential roles of ER-beta in prostate carcinogenesis and utility of ER-beta SERMs in prostate cancer treatment. ..
  39. SYNERGY BETWEEN SSRIS AND OVARIAN HORMONES
    NANCY MUMA; Fiscal Year: 2009
    ..Specific Aim 1 will test the hypothesis that estrogen receptor-beta (ER beta) mediates the increased expression of RGSZ-1 protein and mRNA and desensitization of the 5-HT1A receptors...
  40. Neural Control of the Circulation: Sex and Hypertension
    Baojian Xue; Fiscal Year: 2013
    ..of estrogen or estrogen receptor agonists selective for estrogen receptor a (ERa) or for estrogen receptor b (ERb) into the brain restores protection in OVX females...
  41. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..It is suggested this enhancement results from cooperative activation of the nuclear E2 receptor (ER) ERb, through non-classical, transcription independent mechanisms and the membrane bound Gs-coupled E2 receptor GPR30, ..
  42. Effects of Dietary Soy on Biomarkers in Prostate Cancer
    J Cline; Fiscal Year: 2004
    ..in prostatic tissue, and may have selective activity in the prostate because of their affinity for estrogen receptor beta, which is abundant in prostatic epithelium...
  43. Biotransformation of Estrogens to Carcinogenic Quinoids
    JUDY BOLTON; Fiscal Year: 2005
    ..We will further investigate the role of ERa and/or ERb in mediating catechol estrogen-induced DNA damage and toxicity...
  44. Chemoprevention of Prostate Cancer via Estrogen Receptor B Agonists
    Michael Pawlita; Fiscal Year: 2013
    ..this task order is to evaluate two selective estrogen receptor (ER) agonists, Prinaberel (ERB-041) and LY500307, in inhibition of androgen-dependent prostate carcinogenesis induced in the Wistar-Unilever rat ..
  45. Estrogen and Progesterone-related Gene Variants and Colorectal Cancer Risk
    Shumin Zhang; Fiscal Year: 2009
    ....
  46. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
    ..This will be achieved by inducing EAE in ER beta knockout mice and assessing whether treatment with estrogens are still protective...
  47. Michael Clarke; Fiscal Year: 2014
    ..In this grant, we will use this technology in order to compare the cellular hierarchies of ER-,PR-, ERB-B2- (triple negative) breast tumors of different ethnicities to the cell types found in nonnal breast epithelium...
  48. Estrogens, Paracrine Factors, and Endometrial Cancer
    David Kaufman; Fiscal Year: 2006
    ..Using these cells and specific inhibitors of ER alpha and ER beta we will investigate the respective roles of the two receptors in regulating the synthesis of paracrine factors...
  49. Genome-wide epigenetic control of circadian metabolism by heme receptor Rev-erb
    Mitchell A Lazar; Fiscal Year: 2010
    ..The heme receptor Rev-erb was identified by the PI in 1989, and has since emerged as an important repressor of key genes controlling ..
  50. Biology of nuclear receptor rev-erb alpha in circadian rhythm and metabolism
    Lei Yin; Fiscal Year: 2009
    ..The orphan nuclear receptor Rev-erb( emerged as a core circadian gene...
  51. MSM Mapping and Modeling ErbB Receptor Membrane Topogra
    Bridget S Wilson; Fiscal Year: 2012
    ..with stochastic modeling, we have already challenged current estimations of homo- and hetero-dimerization between Erb family members...
  52. Biology of nuclear receptor rev-erb alpha in circadian rhythm and metabolism
    Lei Yin; Fiscal Year: 2011
    ..In addition, this work may shed the new light on Identifying the new therapeutic targets for treating Insulin resistance and diabetes. ..
  53. Thomas P Burris; Fiscal Year: 2014
    ..we have developed the first synthetic agonists (that have in vivo activity) for the nuclear receptors, REV-ERB[unreadable] and REV-ERB[unreadable], which play a critical role in regulation of the mammalian clock...
  54. Preventive Web-Based Intervention for Spouses of Traumatized Military Personnel
    BENTSON H contact MCFARLAND; Fiscal Year: 2010
    ..which was reviewed on November 9, 2007 by National Institute of Mental Health Special Emphasis Panel ZMH1 ERB-N (02) (Prevention of Trauma Related Adjustment and Mental Disorders in High-Risk Occupations)...
  55. Regulation of REV-ERBalpha and REV-ERBbeta function of HEME
    Thomas P Burris; Fiscal Year: 2012
    ..Recently, the ligand for a pair of related orphan nuclear hormone receptors that regulate lipid metabolism, rev-erb? and rev-erb?, was identified...
  56. Genetics and the Environment Associated with Male Reproduction (GEAR)
    Sheela Sathyanarayana; Fiscal Year: 2012
    ....
  57. Caveolin-1 and Altered Neuregulinism in Diabetic Neuropathy
    Rick T Dobrowsky; Fiscal Year: 2012
    ..NRG1) is a gliotrophic growth factor that promotes cell survival, mitogenesis and myelination by activating Erb B receptor tyrosine kinases in developing SCs...
  58. Chimeric IgG/A Tumor Immunotherapy
    KEITH WYCOFF; Fiscal Year: 2013
    ..IgG and chimeric IgG/A, each with two different N- glycosylation types), all bearing the same anti-HER-2/neu/c-Erb-B2 Fab region, using our plant expression system and evaluate their ability to direct ADCC in vitro against ..
  59. Mechanism of action of the v-erb A oncogene of AEV.
    Martin L Privalsky; Fiscal Year: 2012
    We propose to better understand the mechanisms of action of the v-erb A oncogene, and to relate the role of v-erb A in viral neoplasia to events in normal differentiation and in human disease...
  60. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2010
    ..We have found that these receptors, rev-erb alpha and rev-erb beta, use heme (iron-porphyrin IX) as their common ligand...
  61. Phyllis A Dennery; Fiscal Year: 2014
    ..heme oxygenase (HO)-1 regulates cellular heme degradation and heme is a key ligand for the nuclear receptor Rev-ERB[unreadable]...
  62. Mitchell A Lazar; Fiscal Year: 2016
    ....
  63. Thomas P Burris; Fiscal Year: 2016
    ..we can modulate the circadian rhythm in vivo with synthetic ligands for a particular nuclear receptor (NR), REV-ERB. REV-ERBalpha is an NR that has a well-characterized role in the regulation of the circadian rhythm...
  64. CATHERINE ANNE MARCINKIEWCZ; Fiscal Year: 2014
    ..BNST), a brain region that was previously shown to be an important neural substrate of anxiety and relapse (Erb 1999)...
  65. Regulation signatures for predicting drug resistance and its molecular mechanisms
    Andrej Bugrim; Fiscal Year: 2010
    ..This goal will be accomplished in two stages. First, we will build and optimize focused network model for global Erb family signaling using well-defined training data and knowledge content...