Genomes and Genes
Gene Symbol: EphB4
Description: EPH receptor B4
Alias: HFASD, HTK, MYK1, TYRO11, ephrin type-B receptor 4, ephrin receptor EphB4, hepatoma transmembrane kinase, soluble EPHB4 variant 1, soluble EPHB4 variant 2, soluble EPHB4 variant 3, tyrosine-protein kinase TYRO11, tyrosine-protein kinase receptor HTK
Publications275 found, 100 shown here
- Preliminary identification of potential PDZ-domain proteins downstream of ephrin B2 during osteoclast differentiation of RAW264.7 cellsYingjie Mao
The Affiliated Hospital of Stomatology, Medical College of Zhejiang University, 395 Yan an Road, Hangzhou, PR China
Int J Mol Med 27:669-77. 2011The EphB4 receptor and ephrin B2 ligand were recently reported to influence the coupling between osteoclasts and osteoblasts in bone biology, but their downstream signaling pathways remain unclear...
- Notch ligand Delta-like 1 is essential for postnatal arteriogenesisAnne Limbourg
Department of Cardiology, Medizinische Hochschule Hannover, Hannover, Germany
Circ Res 100:363-71. 2007..whereas perivascular cells expressed proangiogenic vascular endothelial growth factor, and the ephrin-B2 activator EphB4. In heterozygous Dll1 mutant mice endothelial Notch activation and ephrin-B2 induction after hindlimb ischemia ..
- PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cellsPhilippe Foubert
Institut des Vaisseaux et du Sang, Paris, France
J Clin Invest 117:1527-37. 2007..We postulated that activation of the EphB4/ephrin-B2 system may enhance EPC proangiogenic potential...
- The ephrins and Eph receptors in neural developmentJ G Flanagan
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Neurosci 21:309-45. 1998..This large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system...
- Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular developmentS S Gerety
Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
Mol Cell 4:403-14. 1999..Here we show that EphB4, a specific receptor for ephrin-B2, is exclusively expressed by vascular endothelial cells in embryos and is ..
- Coexpression of ephrin-Bs and their receptors in colon carcinomaWenbiao Liu
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 94:934-9. 2002..In the current study, the authors hypothesized that ephrins may play a role in the growth and development of colon carcinoma and may be expressed differentially in normal and malignant colonic tissues...
- EphB4 expression and biological significance in prostate cancerGuangbin Xia
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA
Cancer Res 65:4623-32. 2005..The aim of our study was to examine the expression and biological role of EphB4 in prostate cancer. EphB4 mRNA is expressed in 64 of 72 (89%) prostate tumor tissues assessed...
- Investigation of the expression of the EphB4 receptor tyrosine kinase in prostate carcinomaYen Ching Lee
Department of Haematology Oncology, The Queen Elizabeth Hospital, Woodville, South Australia, 5011, Australia
BMC Cancer 5:119. 2005The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported.
- EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survivalG Xia
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Oncogene 25:769-80. 2006We sought to evaluate the biological function of the receptor tyrosine kinase EphB4 in bladder cancer...
- The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growthNathalie Kertesz
Vasgene Therapeutics, Inc, 1929 Zonal Ave, Los Angeles, CA 90033, USA
Blood 107:2330-8. 2006The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis...
- EphB4 provides survival advantage to squamous cell carcinoma of the head and neckRizwan Masood
Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA
Int J Cancer 119:1236-48. 2006The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play critical roles in blood vessel maturation, and are frequently overexpressed in a wide variety of cancers...
- Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificityJill E Chrencik
Department of Cellular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 281:28185-92. 2006Increasing evidence implicates the interaction of the EphB4 receptor with its preferred ligand, ephrinB2, in pathological forms of angiogenesis and in tumorigenesis...
- EPHB4 and survival of colorectal cancer patientsVeronica Davalos
Molecular Oncology Program, Institut Catala d Oncologia, Barcelona, Spain
Cancer Res 66:8943-8. 2006..In this study, we evaluate the role of EPHB4 in colorectal cancer and its value as a prognostic marker...
- The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcomeS R Kumar
Department of Surgery, University of Southern California, Los Angeles, CA 90033, USA
Br J Cancer 96:1083-91. 2007b>EphB4 is a member of the largest family of transmembrane receptor tyrosine kinases and plays critical roles in axonal pathfinding and blood vessel maturation. We wanted to determine the biological role of EphB4 in ovarian cancer...
- Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancersS M Alam
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Yanagido 1 1, Gifu City 501 1194, Japan
Br J Cancer 98:845-51. 2008b>EphB4 and ephrinB2 expressions in ovarian cancers were studied to analyse EphB4/ephrinB2 functions against clinical backgrounds. EphB4 and ephrinB2 were dominantly localised in ovarian cancer cells of all cases studied...
- Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancersSyed Mahfuzul Alam
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Yanagido 1 1, Gifu City 501 1194, Japan
Gynecol Oncol 114:84-8. 2009Receptor EphB4 and the corresponding ligand ephrinB2 contribute to tumor growth in various human tumors...
- Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progressionS Ram Kumar
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Res 69:3736-45. 2009..Conversely, EphB4 is absent in normal colon but is expressed in all 102 colorectal cancer specimens analyzed, and its expression ..
- The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cellsLuke Truitt
Department of Chemistry and Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada
Cancer Res 70:1141-53. 2010..EphB6 stimulation induces its tyrosine phosphorylation, which is crucial for its function and is mediated by the EphB4 receptor. This is accompanied by EphB6-c-Cbl interaction and phosphorylation of c-Cbl partner, the Abl kinase...
- Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growthValery Krasnoperov
Vasgene Thereapeutics Inc, Los Angeles, CA, USA
Am J Pathol 176:2029-38. 2010b>EphB4 receptor tyrosine kinase and its cognate ligand EphrinB2 regulate induction and maturation of newly forming vessels. Inhibition of their interaction arrests angiogenesis, vessel maturation, and pericyte recruitment...
- Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancersRifat Hasina
Section of Hematology Oncology, Department of Medicine, Departments of Pathology and Surgery, The University of Chicago, Chicago, IL 60637, USA
Cancer Res 73:184-94. 2013..In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines and primary tumor tissues...
- EphB4 as a therapeutic target in mesotheliomaRen Liu
School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
BMC Cancer 13:269. 2013..A search for novel targets and therapeutics is underway, and recently identified targets include VEGF, Notch, and EphB4-Ephrin-B2. Each of these targets has dual activity, promoting tumor cell growth as well as tumor angiogenesis.
- The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic targetBenjamin D Ferguson
Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
PLoS ONE 8:e67668. 2013..The EphB4 receptor tyrosine kinase has recently emerged as a potential target in several other cancers...
- Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epitheliumG Berclaz
Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Biochem Biophys Res Commun 226:869-75. 1996..In normal human breast, the expression of htk, the human homologue, was also confined to the secretory luminal epithelial cells...
- Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesisZ Nikolova
Department of Clinical Research, University of Berne, Tiefenaustrasse 120, CH 3004 Berne, Switzerland
J Cell Sci 111:2741-51. 1998..We have investigated the expression of a member of this family, EphB4, and its cognate ligand, ephrin-B2, during normal and malignant mouse mammary morphogenesis...
- Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cellsTim Füller
Department of Vascular Biology and Angiogenesis Research, Institute of Molecular Oncology, Tumor Biology Center, Breisacher Strasse 117, 79106 Freiburg, Germany
J Cell Sci 116:2461-70. 2003..Recent studies have identified ephrinB2 and EphB4 as markers and makers of arteriovenous differentiation during vascular development...
- Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblastsSteeve Kwan Tat
University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
Arthritis Rheum 58:3820-30. 2008..It has been suggested that ephrin B2 and its specific receptor EphB4 participate in bone homeostasis...
- Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamilyB D Bennett
Genentech, Inc, South San Francisco, California 94080
J Biol Chem 269:14211-8. 1994..This protein, hepatoma transmembrane kinase or Htk, shares amino acid similarity with the EPH subfamily of tyrosine kinases...
- Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinomaX X Tang
Division of Oncology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
Clin Cancer Res 5:455-60. 1999..In this study, we examined the expression of EPHB1, EPHB2, EPHB3, EPHB4, and EPHB6 in 4 SCLC tumor specimens and 14 cell lines including 3 cell lines derived from these tumor specimens...
- Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusionG den Butter
Department of Surgery, University of Wisconsin, Madison 53792, USA
Transpl Int 8:466-71. 1995..In this study we compared simpler preservation solutions, namely, histidine-tryptophan-ketoglutarate (HTK) and phosphate-buffered sucrose (PBS) with different compositions of UW solution in the isolated perfused rabbit ..
- Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular developmentChad A Cowan
Center for Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
Dev Biol 271:263-71. 2004..receptors (VEGFR-1 and VEGFR-2) that bind VEGF, the Tie-1 and Tie-2 receptors that bind the angiopoietins, and the EphB4 receptor that binds the membrane-anchored ligand ephrin-B2...
- Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancerN Takai
Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
Oncol Rep 8:567-73. 2001..b>EphB4 receptors are a subfamily of receptor tyrosine kinases that are activated by ephrin-B2 ligands and are thought to ..
- Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinomaG Berclaz
Department of Obstetrics and Gynecology, University Hospital, Berne, Switzerland
Ann Oncol 14:220-6. 2003..We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ...
- Gridlock signalling pathway fashions the first embryonic arteryT P Zhong
Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
Nature 414:216-20. 2001..the artery, and expands contiguous regions of the vein, preceded by an increase in expression of the venous marker EphB4 receptor (ephb4) and diminution of expression of the arterial marker ephrin-B2 (efnb2)...
- Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segmentsTimo Wille
Institut fur Physiologische Chemie, Universitatsklinikum, Essen, Germany
J Vasc Surg 47:422-31. 2008..Hypothesizing that this iron-dependent cold-induced injury might also occur in the endothelium of intact vessels, we here set out to optimize the hypothermic storage of blood vessels...
- Soluble EphB4 inhibition of PDGF-induced RPE migration in vitroShikun He
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Invest Ophthalmol Vis Sci 51:543-52. 2010b>EphB4 receptor (EphB4) and its ligand (EphrinB2) play an important role in the regulation of cell adhesion, growth, and migration...
- The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinomaUttam K Sinha
Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Arch Otolaryngol Head Neck Surg 132:1053-9. 2006To examine the expression of EphB4 in tumor tissue, surrounding normal tissue, and metastatic lymph node in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate its association with disease stage and smoking.
- Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinaseNadia Munarini
Department of Clinical Research, University of Berne, Tiefenaustrasse 120, CH 3004 Bern, Switzerland
J Cell Sci 115:25-37. 2002We have previously documented the cell-type-specific and hormone-dependent expression of the EphB4 receptor in the mouse mammary gland...
- Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cellsJonathan W Astin
School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK
Nat Cell Biol 12:1194-204. 2010..The unimpeded migration of metastatic PC-3 cells towards fibroblasts is dependent on activation of EphB3 and EphB4 by ephrin-B2, which we show activates Cdc42 and cell migration...
- Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breastGilles Berclaz
Department of Obstetrics and Gynecology, Univeristy Hospital, Inselspital Berne, Schanzeneckstrasse 1, Switzerland
Oncol Rep 9:985-9. 2002..We have previously demonstrated cell type specific and hormone dependent EphB4 expression in the mouse mammary parenchyma suggesting involvement in the homeostasis of this organ...
- Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinomaWhitney A Spannuth
Department of Gynecologic Oncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77230 1439, USA
Mol Cancer Ther 9:2377-88. 2010b>EphB4 is a transmembrane receptor tyrosine kinase that plays an important role in neural plasticity and angiogenesis. EphB4 is overexpressed in ovarian cancer and is predictive of poor clinical outcome...
- Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase HtkB D Bennett
Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
Proc Natl Acad Sci U S A 92:1866-70. 1995b>Htk is a receptor protein-tyrosine kinase that is related to the EPH subfamily of tyrosine kinases. The receptor has a wide tissue distribution including expression in several myeloid hematopoietic cell lines...
- Mutagenesis of uracil-DNA glycosylase deficient mutants of the extremely thermophilic eubacterium Thermus thermophilusTomoya Sakai
School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
DNA Repair (Amst) 7:663-9. 2008..We then disrupted udgA and udgB by thermostable kanamycin-resistant gene (htk) or pyrE gene insertion in each hisD background, and their spontaneous His(+) reversion frequencies were compared...
- EphrinB2 and EphB4 expression in pterygia: new insights and preliminary resultsChunyan Xue
Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, China
Can J Ophthalmol 44:185-8. 2009..The ephrin-Eph system, especially ephrinB2 and its receptor EphB4, has been shown to play an important role in tumor angiogenesis...
- Humanized anti-EphB4 antibodies for the treatment of carcinomas and vasculogenesis-related diseasesZenghui Xu
Zhejiang Sci Tech University, Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Hangzhou, China
Expert Opin Ther Pat 19:1035-7. 2009The invention provides human, humanized or chimeric versions of anti-EphB4 mouse monoclonal antibodies that bind to the human EphB4 receptor tyrosine kinase...
- Communication between ephrinB2 and EphB4 within the osteoblast lineageT J Martin
Department of Medicine, St Vincent s Institute and University of Melbourne, Melbourne, Fitzroy, 3065, Australia
Adv Exp Med Biol 658:51-60. 2010..Both a synthetic peptide antagonist of ephrinB2/EphB4 receptor interaction and recombinant soluble extracellular domain of EphB4 (sEphB4), which is an antagonist of ..
- Structure-based tailoring of compound libraries for high-throughput screening: discovery of novel EphB4 kinase inhibitorsPeter Kolb
Department of Biochemistry, University of Zurich, CH 8057 Zurich, Switzerland
Proteins 73:11-8. 2008..is additionally used here to identify molecules with optimal anchor fragments for the ATP-binding site of the EphB4 receptor tyrosine kinase...
- In vivo small-animal PET/CT of EphB4 receptors using 64Cu-labeled peptideChiyi Xiong
Department of Experimental Diagnostic Imaging, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Nucl Med 52:241-8. 2011Many solid tumors overexpress EphB4 receptor, a member of the ephrin receptor tyrosine kinase family...
- Paradoxes of the EphB4 receptor in cancerNicole K Noren
Burnham Institute for Medical Research and Pathology Department, University of California San Diego, La Jolla, California 92037, USA
Cancer Res 67:3994-7. 2007..This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer...
- Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cellsMichael H Davies
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
Microvasc Res 77:382-6. 2009b>EphB4 receptors and their ephrinB2 ligands are essential for vascular development, but also play a role in pathological neovascularization (NV)...
- Mammary epithelial-specific knockout of the ephrin-B2 gene leads to precocious epithelial cell death at lactationStéphanie Weiler
Department of Clinical Research, University of Bern, Tiefenaustrasse 120, Bern, Switzerland
Dev Growth Differ 51:809-19. 2009..We have previously shown that EphB4 and ephrinB2 are differentially expressed during the development of the adult mammary parenchyma...
- Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4Scott A Mitchell
Department of Medicinal Chemistry, CGI Pharmaceuticals, Inc, 36 East Industrial Road, Branford, CT 06405, USA
Bioorg Med Chem Lett 19:6991-5. 2009..b>EphB4, a receptor tyrosine kinase (RTK) involved in the processes of embryogenesis and angiogenesis, has been shown to ..
- Up-regulation of EphB and ephrin-B expression in rhabdomyosarcomaAnna C Berardi
Laboratory of Stem Cells, Bambino Gesu Children s Hospital, I 00165 Rome, Italy
Anticancer Res 28:763-9. 2008..Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated...
- Ability of structurally related polycyclic aromatic carcinogens to induce homologous recombination between duplicated chromosomal sequences in mouse L cellsN P Bhattacharyya
Department of Microbiology, Michigan State University, East Lansing 48824 1316
Mutat Res 211:205-14. 1989..their ability to cause intrachromosomal homologous recombination between two herpes simplex virus thymidine kinase (Htk) genes stably integrated in the genome of a tk- mouse L cell strain 333 M...
- Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cellsN W Gale
Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, New York, 10591 6707, USA
Dev Biol 230:151-60. 2001..molecular marker for the arterial endothelium at the earliest stages of embryonic angiogenesis, while its receptor EphB4 reciprocally marks the venous endothelium...
- Comparative analysis of embryonic gene expression defines potential interaction sites for Xenopus EphB4 receptors with ephrin-B ligandsP M Helbling
Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
Dev Dyn 216:361-73. 1999..We describe here the isolation of cDNAs encoding Xenopus EphB4 receptors and show that embryonic expression is prominently associated with the developing vasculature, newly ..
- Ena/VASP proteins mediate repulsion from ephrin ligandsIwan R Evans
Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
J Cell Sci 120:289-98. 2007..Moreover, when EphB4 and ephrin-B2 were expressed in neighbouring Swiss 3T3 fibroblasts, VASP and Mena co-accumulated with activated ..
- Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligandsS J Holland
Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Nature 383:722-5. 1996..Here we show that challenging cells that express the TM ligands Elk-L or Htk-L with the clustered ectodomain of Nuk induces phosphorylation of the ligands on tyrosine, a process that can be ..
- Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformationsStefanie Diehl
Max Planck Institut fur Neurobiologie, Martinsried, Germany
Pediatr Res 57:537-44. 2005..members show a complementary expression pattern in blood vessels, with ephrinB2 being expressed on arterial and EphB4 on venous endothelium...
- Comparison of EphA receptor tyrosine kinases and ephrinA ligand expression to EphB-ephrinB in vascularized corneasTakashi Kojima
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL 60612, USA
Cornea 26:569-78. 2007....
- Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endotheliumRizwan Masood
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Blood 105:1310-8. 2005..Ephrin B2 and ephrin B4 (EphB4) are artery- and vein-specific proteins, respectively, with critical roles in vessel maturation...
- The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockadeJeffrey S Scehnet
Department of Pathology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
Blood 113:254-63. 2009..as the induction of EphrinB2, which phenotypically defines arterial endothelial cells and pericytes, and represses EphB4, which defines venous endothelial cells...
- Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-alpha-acetyl-L-histidineTamas Radovits
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 27:208-16. 2008..This screening study tested the effects of iron chelator supplementation in different histidine-tryptophan-ketoglutarate (HTK) organ preservation solutions on endothelial function in a long-term storage model of the isolated rat aorta.
- Organ preservation with histidine-tryptophan ketogluatarate solution in clinical pancreas transplantation: an update of the indiana university experienceA Agarwal
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
Transplant Proc 40:498-501. 2008In May 2003, University of Wisconsin (UW) solution was replaced with Histidine-Tryptophan Ketoglutarate (HTK) solution as the preservation fluid for abdominal organ procurements in our center...
- Pretreatment with calcitonin gene-related peptide attenuates hepatic ischemia/reperfusion injury in ratsS W Song
Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China
Transplant Proc 41:1493-8. 2009..We sought to investigate the protective effect of calcitonin gene-related peptide (CGRP) to attenuate liver I/R injury due to oxygen free radicals and apoptosis...
- Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelatorsU Rauen
Institut fur Physiologische Chemie, Universitatsklinikum, Hufelandstr 55, 45122, Essen, Germany
Cell Mol Life Sci 64:192-205. 2007..When cultured hepatocytes were incubated in HTK solution or in modified Krebs-Henseleit buffer containing 198 mM L-histidine at 37 degrees C, most cells lost ..
- Influence on energy kinetics and histology of different preservation solutions seen during cold ischemia in the liverC L Corps
Transplant Science Group, Department of Hepatology and Transplantation, St James s University Hospital, Leeds West Yorkshire LS9 7TF, United Kingdom
Transplant Proc 41:4088-93. 2009..over time, using three preservation solutions: University of Wisconsin (UW), histidine-tryptophan-ketoglutarate (HTK), and Leeds solution (LS) under development at our institution...
- Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responsesE Stein
Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Genes Dev 12:667-78. 1998Eph family receptor tyrosine kinases (including EphA3, EphB4) direct pathfinding of neurons within migratory fields of cells expressing gradients of their membrane-bound ligands...
- Improving the preservation of isolated rat skeletal muscles stored for 16 hours at 4 degrees CE P van der Heijden
Department of Plastic, Reconstructive and Handsurgery, University Medical Center of Utrecht, The Netherlands
Transplantation 69:1310-22. 2000..In the present study, we investigated whether muscle preservation during cold storage could be improved by additives that can protect against such processes or by oxygen supply...
- The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancersQinghua Wu
Department of Pathology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
Epigenetics 2:237-43. 2007..their promoters, we analyzed the promoter methylation status of three members of the EPHB family, EPHB2, EPHB3 and EPHB4, in a series of 22 colon cancer cell lines, as well as in four ovarian cancer cell lines and 56 ovarian tumor ..
- Preponderance of cells with stem cell characteristics in metastasising mouse mammary tumours induced by deregulated EphB4 and ephrin-B2 expressionPhilip Kaenel
Department of Clinical Research, University of Bern, Tiefenaustrasse 120c, CH 3004 Bern, Switzerland
Int J Oncol 38:151-60. 2011We have previously shown that EphB4 and ephrin-B2 are differentially expressed in the mammary gland and that their deregulated expression in the mammary epithelium of transgenic mice leads to perturbations of the mammary parenchyma and ..
- Expression of ephrinB2 and its receptors on fibroproliferative membranes in ocular angiogenic diseasesNaoyasu Umeda
Department of Ophthalmology, Fukuoka University, School of Medicine, Fukuoka, Japan
Am J Ophthalmol 138:270-9. 2004..To determine whether ephrinB2 plays a role in ocular angiogenesis, we investigated the expression of ephrinB2 and EphB receptors on retinal fibroproliferative membranes...
- Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjectsSandra C Christiansen
Southern California Kaiser Permanente Medical Group, San Diego, Calif, USA
Int Arch Allergy Immunol 147:299-304. 2008..We previously identified human tissue kallikrein (hTK) as the principal lung kininogenase during allergic airway inflammation...
- Improved vessel preservation after 4 days of cold storage: experimental study in rat arteriesBirgit Zatschler
Department of Physiology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany
J Vasc Surg 50:397-406. 2009..Cold storage of arteries for reconstructive and bypass surgery may result in injury of endothelial cells which may promote low perfusion and graft vasculopathy...
- Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase geneK Ikenaka
National Institute for Physiological Sciences, Okazaki National Research Institutes
Hum Cell 14:49-58. 2001We prepared retroviruses carrying the lacZ gene or herpes simplex virus thymidine kinase (HTK) gene with titers of 1.4-2...
- Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemiaCostanza Emanueli
Bristol Heart Institute, University of Bristol, Bristol, UK
Front Biosci 12:2003-12. 2007..we have tested the therapeutic potential of local angiogenesis gene therapy with human tissue kallikrein (hTK) or constitutively-activated Akt kinase (Myr-Akt)...
- Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesisYung Hae Kim
Department of Surgery, University of California, San Francisco, CA 94143, USA
Development 135:3755-64. 2008..Loss of ephrin B2 or its receptor EphB4 also leads to enlarged aortae and underdeveloped cardinal veins; however, endothelial cells with venous identity ..
- Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neckMachiko Kimura
Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama 236 0004, Japan
Int J Oncol 34:321-7. 2009The ephB4-ephrinB2 system plays an important role in the interaction of tumor cells with endothelial cells (ECs)...
- Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptorsR Brambilla
European Molecular Biology Laboratory, Heidelberg, Germany
Mol Cell Neurosci 8:199-209. 1996..The common receptors Cek10 and Elk bind and signal in response to Lerk2 and Elf2, whereas the Myk1 receptor is specific for Elf2...
- [Perfusion strategies of extracorporeal circulation for robotically assisted cardiac surgery]Jia li Wang
Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China
Nan Fang Yi Ke Da Xue Xue Bao 29:2300-1. 2009..To discuss the management of extracorporeal circulation (ECC) for robotically assisted cardiac surgery...
- The relationship between oncogene expression and clinical outcome in endometrial carcinomaNoriyuki Takai
Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita, 879 5593, Japan
Curr Cancer Drug Targets 4:511-20. 2004..Scoring on the basis of the percentage of positive cells indicated that Plks, EphB4, ephrin-B2, Id1, CaMKIV, c-Ets1, Elf-1, and survivin expression were significantly associated with PCNA-labeling ..
- Origin, differentiation, and maturation of human pulmonary veinsSusan M Hall
Unit of Vascular Biology and Pharmacology, Institute of Child Health, University College, London, United Kingdom
Am J Respir Cell Mol Biol 26:333-40. 2002..and desmin) and antibodies specific for the matrix glycoprotein tenascin, the receptor protein tyrosine kinase EphB4, and its ligand ephrinB2...
- Eurotransplant randomized multicenter kidney graft preservation study comparing HTK with UW and Euro-CollinsJ de Boer
Eurotransplant International Foundation, Leiden, The Netherlands
Transpl Int 12:447-53. 1999The aim was to evaluate the effect of HTK compared to UW and Euro-Collins (EC) on the initial graft function and long term graft survival in two prospective randomized studies...
- Selective expression of the receptor tyrosine kinase, HTK, on human erythroid progenitor cellsT Inada
Department of Cell Differentiation, Kumamoto University School of Medicine, Kumamoto City, Japan
Blood 89:2757-65. 1997b>HTK is a receptor tyrosine kinase of the Eph family. To characterize the involvement of HTK in hematopoiesis, we generated monoclonal antibodies against HTK and investigated its expression on human bone marrow cells...
- Targeting the DFG-in kinase conformation: a new trend emerging from a patent analysisMauro Angiolini
Medicinal Chemistry Department, Oncology Business Unit, Nerviano Medical Sciences, 20014 Nerviano, Italy
Future Med Chem 3:309-37. 2011..by the so-called 'Type I½' inhibitor, against a small set of clinically relevant targets such as B-Raf, p38α, Jak2 and EphB4. Preclinical and clinical data are also highlighted for the most promising new molecular entities.
- Impact of the incubation medium on the endothelium of autologous vein grafts: damage scoring by scanning electron microscopyM A Konerding
Department of Macroscopic Anatomy, University of Mainz, Germany
Scanning Microsc 10:841-8; discussion 848-9. 1996..served as controls; the others were assigned to test groups and exposed to heparinized whole blood, Bretschneider's HTK, human albumin or Ringer's solution...
- In vitro function of porcine carotid arteries preserved in UW, HTK and Celsior solutionsS T L Abrahamse
Department of Surgery Surgical Laboratory, Academic Medical Center, The University of Amsterdam, The Netherlands
Fundam Clin Pharmacol 16:503-11. 2002We compared the efficacy of histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solution with Celsior solution using hypothermically-preserved porcine carotid arteries and studied the importance of different ..
- Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantationJonathan A Fridell
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Transplantation 77:1304-6. 2004..This study assesses the efficacy of histidine-tryptophan-ketoglutarate (HTK) compared with UW in pancreas transplantation.
- Wash-out of the non-heart-beating donor liver: a comparison between ringer lactate, HTK, and polysolM Bessems
Surgical Laboratory, Academic Medical Center, Amsterdam, The Netherlands
Transplant Proc 37:395-8. 2005The solution of choice for wash-out of non-heart-beating donor (NHBD) livers is histidine tryptophan ketoglutarate (HTK)...
- Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificityJill E Chrencik
Department of Cellular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
Structure 14:321-30. 2006..We report the crystal structure of the EphB4 receptor in complex with a highly specific antagonistic peptide at a resolution of 1.65 angstroms...
- EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodelingOmbretta Salvucci
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 108:2914-22. 2006..We describe how endogenous EphB2 and EphB4 signaling are required for the formation of extracellular matrix-dependent capillary-like structures in primary ..
- Preclinical evaluation of coronary vascular function after cardioplegia with HTK and different antioxidant additivesCornelia Schröder
Institute of Physiology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany
Eur J Cardiothorac Surg 31:821-6. 2007..Due to limited resources, improvement of preservation solutions is still of great importance in cardiac transplant surgery. New additives with antioxidant properties were tested with respect to coronary function of isolated rat hearts...
- Evaluation of a novel cold storage solution (HBs) in a rat kidney transplant modelFernando Lopez-Neblina
Discovery Research Laboratories, Human Biosystems Michigan Branch, Vicksburg, Michigan, USA
J Invest Surg 20:257-63. 2007..The animals were divided into three groups based upon the preservation solution utilized: HBS solution, HTK solution (Custodiol), and UW solution (UWS)(ViaSpan). Among the recipients, each group had two subsets...
- Electrical impedance of the liver during experimental long-term liver preservationP Cascales-Sanchez
Service of General Surgery, Albacete Universitary General Hospital, Albacete, Spain
Transplant Proc 39:2118-9. 2007..rabbit liver during long-term preservation with University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solution...
- Osteoclast-osteoblast communicationKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
Arch Biochem Biophys 473:201-9. 2008..Bidirectional signaling generated by interaction between ephrinB2 on osteoclasts and EphB4 on osteoblast precursors facilitates the transition...
- Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in adult liver transplantationF Rayya
Clinic for Visceral, Transplantation, Thoracic and Vascular Surgery, University Leipzig, Leipzig, Germany
Transplant Proc 40:891-4. 2008A safe and effective preservation solution is a precondition for successful orthotopic liver transplantation (OLT). This study compared University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions in OLT.
- Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in intestinal and multivisceral transplantationRichard S Mangus
Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
Transplantation 86:298-302. 2008Previous studies have failed to demonstrate a clinical difference between histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) preservation solutions in clinical transplant outcomes for liver, pancreas, and kidney ..
- Organ preservation solutions attenuate accumulation and nuclear translocation of hypoxia-inducible factor-1alpha in the hepatoma cell line HepG2Renate Paddenberg
Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
Cell Biochem Funct 27:516-25. 2009..we determined the impact of organ preservation solutions (Celsior; histidine-tryptophan-ketoglutarate solution, HTK; University of Wisconsin solution; UW), oxygen supply, and temperature on HIF-1alpha accumulation, recorded by ..
- BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4Momoko Suzuki
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
Eur J Haematol 84:229-38. 2010..We investigated the mechanism responsible for imatinib (IM) resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) cell lines...
- Assessment of buffer systems for harvesting proteins from tissue interstitial fluid for proteomic analysisPang Ning Teng
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA
J Proteome Res 9:4161-9. 2010..three organ transplantation preservative solutions: Celsior solution S (CS), histidine-tryptophan-ketoglutarate (HTK), and University of Wisconsin (UW)...
- One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized studyBjørn Braathen
Department of Cardiothoracic Surgery, Oslo University Hospital Ulleval, Oslo, Norway
J Thorac Cardiovasc Surg 141:995-1001. 2011Histidine-tryptophan-ketoglutarate (HTK-Custodiol) cardioplegic solution is administered as one single dose for more than 2 hours of ischemia...
- Complementary expression of EphB receptors and ephrin-B ligand in the pyloric and duodenal epithelium of adult miceMaki Ishii
Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Japan
Histochem Cell Biol 136:345-56. 2011..In contrast, EphB2, EphB3, and EphB4 were expressed in pyloric glandular cells and proliferating cells of the isthmus...
- The EphB4 Receptor as a Novel Breast Cancer TargetElena B Pasquale; Fiscal Year: 2010Receptor tyrosine kinases of the Eph family are upregulated in different types of cancer. EphB4 has been linked to breast cancer and other types of cancer, but little is known about how this receptor may contribute to oncogenesis...
- EphB4 Receptor Tyrosine Kinase RTK Targeted Humanized Monoclonal Antibody h131VALERY G KRASNOPEROV; Fiscal Year: 2012..studies will be performed in addition to those already done to determine if Kras mutant tumors or tumors with EphB4 gene amplification are more susceptible to h131 treatment measured by tumor regression instead of reduction in the ..
- Eph/ephrin signaling in craniofacial development and diseaseJEFFREY OHMANN BUSH; Fiscal Year: 2010..Based on preliminary expression data, EphB4, an important receptor for ephrin-B2 is highly expressed within the palate during its formation...
- Eph/ephrin signaling in craniofacial development and diseaseJEFFREY OHMANN BUSH; Fiscal Year: 2013..Based on preliminary expression data, EphB4, an important receptor for ephrin-B2 is highly expressed within the palate during its formation...
- Structural determinants of promiscuity and selectivity iin Ephrin_Eph binding.Peter Kuhn; Fiscal Year: 2010..interfaces across the family, including highly promiscuous receptors (EphB2, EphA4) and highly specific receptors (EphB4, EphA2)...
- sEphB4-HSA A Pre-Clinical Candidate for OncologyVALERY G KRASNOPEROV; Fiscal Year: 2012DESCRIPTION (provided by applicant): This is aimed at the pre-clinical development of soluble EphB4-HSA (sEphB4-HSA) and its ultimate commercialization for the treatment of various cancer types...
- EphB4 as Novel Target for Breast Cancer ImagingPETER STEPHEN CONTI; Fiscal Year: 2012..In particular, up-regulation of EphB4 expression has been found in mouse mammary tumor models and in more than half of the human breast cancer specimens ..
- Candece L Gladson; Fiscal Year: 2016..molecule ephrin-B2 on the ECs based on array analysis and blocking studies using recombinant ephrin-B2-Fc and EphB4-Fc (the ephrin-B2 receptor)...
- VALERY G KRASNOPEROV; Fiscal Year: 2014DESCRIPTION (provided by applicant): During embryonic development, EphB4 and EphrinB2 are both critically required for maturation of newly forming blood vessels. EphrinB2 and is critically required for activation of VEGFR2/3...
- Novel Role of Corneal Crystallins as Modulators of Cell Growth and TransparencyVasilis Vasiliou; Fiscal Year: 2011..Human corneal epithelial and keratocyte telomerase immortalized cell lines (hTCepi and hTK) will be stably transfected with a tetracycline-inducible mammalian expression vector carrying cDNAs of wild type ..
- Host Vascular Mechanism for Therapeutic Protection against Select PathogensJoanne Chan; Fiscal Year: 2013..current knowledge on 3 key angiogenic factors and their receptors, VEGF-A/VEGFR2, Angiopoietin 1/Tie2 and ephrinB2/EphB4, to establish reliable models for vascular integrity...
- Zibo Li; Fiscal Year: 2016..approach that for pretargeted imaging/radioimmunotherapy of cancer based on the tetrazine-TCO ligation and anti-EphB4 antibody...
- VEGF-dependent and - Independent Anti-angiogenic TherapyCalvin Kuo; Fiscal Year: 2006..This will be accomplished using several new adenoviruses designed to antagonize the TIE/angiopoietin and EphB4/ephrin-B2 endothelial receptor tyrosine kinase pathways...
- A new approach to the treatment of Retinopathy of PrematurityPaul A Yates; Fiscal Year: 2013..Specific Aim III is to determine whether two molecules involved in blood vessel growth, ephrin-B2 and EphB4, are involved in ROP and if they might be a good target to treat the disease.
- Ephrins and Repeated CocaineRobert Pierce; Fiscal Year: 2006..In mammals, eight ephrins (ephrinA1-ephrinA5; ephrinB1-ephrinB3) and thirteen Eph receptors (EphA1-EphA8; EphB1-EphB4, EphB6) have been identified to date...
- Genomic Instability and Etiology of Estrogen OncogenesisJonathan Li; Fiscal Year: 2007..and aneuploidy in a unique, but relevant animal tumor model, the E-induced malignant tumors in the hamster kidney (HTK). SPECIFIC AIM 1...
- GENETIC ANALYSIS OF EPHRIN-EPH SIGNALING IN ANGIOGENESISDavid Anderson; Fiscal Year: 2005..expressed by arterial but not venous endothelial cells in both embryos and adults, whereas its receptor EphB4 is conversely expressed by veins but not arteries...
- The Role of Mast Cells in Tumor AngiogenesisDarya Soto; Fiscal Year: 2006..mast cells and endothelial cells in the development of tumor angiogenesis, in particular the role of ephrinB2 and EphB4 in this process. EphB4 is one member of a receptor tyrosine kinase family, and its co-receptor is ephrinB2...
- EphB4 modulates hemangioblast developmentZack Wang; Fiscal Year: 2007..Endothelial cell receptor tyrosine kinase EphB4 (HTK) and its ligand, ephrinB2, are critical for angiogenesis...
- DongBao Chen; Fiscal Year: 2016..These studies are relevant to uncover the dilemma of the cardiovascular protective effects of estrogen. ..
- OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATESCYNTHIA LOUISE BETHEA; Fiscal Year: 2010..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
- Regulation of Angiogenesis via EphB4 SignalingJENA STEINLE; Fiscal Year: 2002..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
- Rhesus Embryonic Stem Cell-Derived Serotonin NeuronsCYNTHIA BETHEA; Fiscal Year: 2007..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
- Effects of the Mevalonate Pathway on Bone FormationGregory Mundy; Fiscal Year: 2007..unreadable] [unreadable]..
- EphA2 Agonists as Novel Inhibitors of Tumor ProgressionBingcheng Wang; Fiscal Year: 2007..Completion of the proposed studies can lead to new mechanism-based therapeutic agents and strategies for prostate cancer. ..
- Phase I Clinical Trials of Anti-Cancer AgentsFrancis Giles; Fiscal Year: 2007..abstract_text> ..
- Eph Kinase Signaling in Prostate CancerBingcheng Wang; Fiscal Year: 2004....
- TRAINING PROGRAM IN BONE AND MINERAL METABOLISMGregory Mundy; Fiscal Year: 2002..Of the trainees supported by the NIH Institutional Training Grant, we have had 25 graduates, 18 of whom are in full-time academic/ research careers. ..
- Gli Control of PTH-rP and Osteolysis in Breast CancerGregory Mundy; Fiscal Year: 2009..We propose therefore that the Gli family of transcriptional regulators represents an important molecular pathway that regulates PTH-rP expression in breast cancer cells, and subsequent breast cancer-mediated osteolysis. ..
- VEGFs in Artery-Vein Imbalance in AIDS-Kaposi SarcomaParkash Gill; Fiscal Year: 2009..proteins which mark this distinction are ephrin B2, expressed on arterial endothelial cells, and its receptor, EphB4, which is expressed on venous endothelial cells...
- THE UBIQUITIN-PROTEOSOME PATHWAY AND BMP-2 EXPRESSIONGregory Mundy; Fiscal Year: 2008..abstract_text> ..
- Caveolin-1, Caveolae and Placental AngiogenesisDongBao Chen; Fiscal Year: 2007....
- EMAP II Regulation of Pulmonary Cell ProliferationMARGARET SCHWARZ; Fiscal Year: 2007..abstract_text> ..
- Vasculature is a determinant of epithelial morphogenesisMARGARET SCHWARZ; Fiscal Year: 2006..Thus, identifying the factors responsible for coordinating vascular formation and distal lung morphogenesis will provide insight into the determinants by which their balance can affect lung development. ..
- IVth Intl Conference on Cancer-Induced Bone DiseasesGregory Mundy; Fiscal Year: 2004..Attention will also be given to current diagnostic methods for patients with these skeletal complications of malignancy. ..