EphB4

Summary

Gene Symbol: EphB4
Description: EPH receptor B4
Alias: HFASD, HTK, MYK1, TYRO11, ephrin type-B receptor 4, ephrin receptor EphB4, hepatoma transmembrane kinase, soluble EPHB4 variant 1, soluble EPHB4 variant 2, soluble EPHB4 variant 3, tyrosine-protein kinase TYRO11, tyrosine-protein kinase receptor HTK
Species: human

Top Publications

  1. doi Preliminary identification of potential PDZ-domain proteins downstream of ephrin B2 during osteoclast differentiation of RAW264.7 cells
    Yingjie Mao
    The Affiliated Hospital of Stomatology, Medical College of Zhejiang University, 395 Yan an Road, Hangzhou, PR China
    Int J Mol Med 27:669-77. 2011
  2. ncbi Notch ligand Delta-like 1 is essential for postnatal arteriogenesis
    Anne Limbourg
    Department of Cardiology, Medizinische Hochschule Hannover, Hannover, Germany
    Circ Res 100:363-71. 2007
  3. pmc PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
    Philippe Foubert
    Institut des Vaisseaux et du Sang, Paris, France
    J Clin Invest 117:1527-37. 2007
  4. ncbi The ephrins and Eph receptors in neural development
    J G Flanagan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 21:309-45. 1998
  5. ncbi Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
    S S Gerety
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Mol Cell 4:403-14. 1999
  6. ncbi Coexpression of ephrin-Bs and their receptors in colon carcinoma
    Wenbiao Liu
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 94:934-9. 2002
  7. ncbi EphB4 expression and biological significance in prostate cancer
    Guangbin Xia
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA
    Cancer Res 65:4623-32. 2005
  8. pmc Investigation of the expression of the EphB4 receptor tyrosine kinase in prostate carcinoma
    Yen Ching Lee
    Department of Haematology Oncology, The Queen Elizabeth Hospital, Woodville, South Australia, 5011, Australia
    BMC Cancer 5:119. 2005
  9. ncbi EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival
    G Xia
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Oncogene 25:769-80. 2006
  10. pmc The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth
    Nathalie Kertesz
    Vasgene Therapeutics, Inc, 1929 Zonal Ave, Los Angeles, CA 90033, USA
    Blood 107:2330-8. 2006

Research Grants

  1. The EphB4 Receptor as a Novel Breast Cancer Target
    Elena B Pasquale; Fiscal Year: 2010
  2. EphB4 Receptor Tyrosine Kinase RTK Targeted Humanized Monoclonal Antibody h131
    VALERY G KRASNOPEROV; Fiscal Year: 2012
  3. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
  4. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
  5. Structural determinants of promiscuity and selectivity iin Ephrin_Eph binding.
    Peter Kuhn; Fiscal Year: 2010
  6. sEphB4-HSA A Pre-Clinical Candidate for Oncology
    VALERY G KRASNOPEROV; Fiscal Year: 2012
  7. EphB4 as Novel Target for Breast Cancer Imaging
    PETER STEPHEN CONTI; Fiscal Year: 2012
  8. Candece L Gladson; Fiscal Year: 2016
  9. VALERY G KRASNOPEROV; Fiscal Year: 2014
  10. Novel Role of Corneal Crystallins as Modulators of Cell Growth and Transparency
    Vasilis Vasiliou; Fiscal Year: 2011

Detail Information

Publications275 found, 100 shown here

  1. doi Preliminary identification of potential PDZ-domain proteins downstream of ephrin B2 during osteoclast differentiation of RAW264.7 cells
    Yingjie Mao
    The Affiliated Hospital of Stomatology, Medical College of Zhejiang University, 395 Yan an Road, Hangzhou, PR China
    Int J Mol Med 27:669-77. 2011
    The EphB4 receptor and ephrin B2 ligand were recently reported to influence the coupling between osteoclasts and osteoblasts in bone biology, but their downstream signaling pathways remain unclear...
  2. ncbi Notch ligand Delta-like 1 is essential for postnatal arteriogenesis
    Anne Limbourg
    Department of Cardiology, Medizinische Hochschule Hannover, Hannover, Germany
    Circ Res 100:363-71. 2007
    ..whereas perivascular cells expressed proangiogenic vascular endothelial growth factor, and the ephrin-B2 activator EphB4. In heterozygous Dll1 mutant mice endothelial Notch activation and ephrin-B2 induction after hindlimb ischemia ..
  3. pmc PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
    Philippe Foubert
    Institut des Vaisseaux et du Sang, Paris, France
    J Clin Invest 117:1527-37. 2007
    ..We postulated that activation of the EphB4/ephrin-B2 system may enhance EPC proangiogenic potential...
  4. ncbi The ephrins and Eph receptors in neural development
    J G Flanagan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 21:309-45. 1998
    ..This large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system...
  5. ncbi Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
    S S Gerety
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Mol Cell 4:403-14. 1999
    ..Here we show that EphB4, a specific receptor for ephrin-B2, is exclusively expressed by vascular endothelial cells in embryos and is ..
  6. ncbi Coexpression of ephrin-Bs and their receptors in colon carcinoma
    Wenbiao Liu
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 94:934-9. 2002
    ..In the current study, the authors hypothesized that ephrins may play a role in the growth and development of colon carcinoma and may be expressed differentially in normal and malignant colonic tissues...
  7. ncbi EphB4 expression and biological significance in prostate cancer
    Guangbin Xia
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA
    Cancer Res 65:4623-32. 2005
    ..The aim of our study was to examine the expression and biological role of EphB4 in prostate cancer. EphB4 mRNA is expressed in 64 of 72 (89%) prostate tumor tissues assessed...
  8. pmc Investigation of the expression of the EphB4 receptor tyrosine kinase in prostate carcinoma
    Yen Ching Lee
    Department of Haematology Oncology, The Queen Elizabeth Hospital, Woodville, South Australia, 5011, Australia
    BMC Cancer 5:119. 2005
    The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported.
  9. ncbi EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival
    G Xia
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Oncogene 25:769-80. 2006
    We sought to evaluate the biological function of the receptor tyrosine kinase EphB4 in bladder cancer...
  10. pmc The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth
    Nathalie Kertesz
    Vasgene Therapeutics, Inc, 1929 Zonal Ave, Los Angeles, CA 90033, USA
    Blood 107:2330-8. 2006
    The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis...
  11. ncbi EphB4 provides survival advantage to squamous cell carcinoma of the head and neck
    Rizwan Masood
    Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 119:1236-48. 2006
    The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play critical roles in blood vessel maturation, and are frequently overexpressed in a wide variety of cancers...
  12. ncbi Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity
    Jill E Chrencik
    Department of Cellular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:28185-92. 2006
    Increasing evidence implicates the interaction of the EphB4 receptor with its preferred ligand, ephrinB2, in pathological forms of angiogenesis and in tumorigenesis...
  13. ncbi EPHB4 and survival of colorectal cancer patients
    Veronica Davalos
    Molecular Oncology Program, Institut Catala d Oncologia, Barcelona, Spain
    Cancer Res 66:8943-8. 2006
    ..In this study, we evaluate the role of EPHB4 in colorectal cancer and its value as a prognostic marker...
  14. pmc The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome
    S R Kumar
    Department of Surgery, University of Southern California, Los Angeles, CA 90033, USA
    Br J Cancer 96:1083-91. 2007
    b>EphB4 is a member of the largest family of transmembrane receptor tyrosine kinases and plays critical roles in axonal pathfinding and blood vessel maturation. We wanted to determine the biological role of EphB4 in ovarian cancer...
  15. pmc Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers
    S M Alam
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Yanagido 1 1, Gifu City 501 1194, Japan
    Br J Cancer 98:845-51. 2008
    b>EphB4 and ephrinB2 expressions in ovarian cancers were studied to analyse EphB4/ephrinB2 functions against clinical backgrounds. EphB4 and ephrinB2 were dominantly localised in ovarian cancer cells of all cases studied...
  16. doi Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers
    Syed Mahfuzul Alam
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Yanagido 1 1, Gifu City 501 1194, Japan
    Gynecol Oncol 114:84-8. 2009
    Receptor EphB4 and the corresponding ligand ephrinB2 contribute to tumor growth in various human tumors...
  17. doi Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression
    S Ram Kumar
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Res 69:3736-45. 2009
    ..Conversely, EphB4 is absent in normal colon but is expressed in all 102 colorectal cancer specimens analyzed, and its expression ..
  18. doi The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells
    Luke Truitt
    Department of Chemistry and Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada
    Cancer Res 70:1141-53. 2010
    ..EphB6 stimulation induces its tyrosine phosphorylation, which is crucial for its function and is mediated by the EphB4 receptor. This is accompanied by EphB6-c-Cbl interaction and phosphorylation of c-Cbl partner, the Abl kinase...
  19. pmc Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth
    Valery Krasnoperov
    Vasgene Thereapeutics Inc, Los Angeles, CA, USA
    Am J Pathol 176:2029-38. 2010
    b>EphB4 receptor tyrosine kinase and its cognate ligand EphrinB2 regulate induction and maturation of newly forming vessels. Inhibition of their interaction arrests angiogenesis, vessel maturation, and pericyte recruitment...
  20. doi Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers
    Rifat Hasina
    Section of Hematology Oncology, Department of Medicine, Departments of Pathology and Surgery, The University of Chicago, Chicago, IL 60637, USA
    Cancer Res 73:184-94. 2013
    ..In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines and primary tumor tissues...
  21. pmc EphB4 as a therapeutic target in mesothelioma
    Ren Liu
    School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    BMC Cancer 13:269. 2013
    ..A search for novel targets and therapeutics is underway, and recently identified targets include VEGF, Notch, and EphB4-Ephrin-B2. Each of these targets has dual activity, promoting tumor cell growth as well as tumor angiogenesis.
  22. pmc The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target
    Benjamin D Ferguson
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    PLoS ONE 8:e67668. 2013
    ..The EphB4 receptor tyrosine kinase has recently emerged as a potential target in several other cancers...
  23. ncbi Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium
    G Berclaz
    Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Biochem Biophys Res Commun 226:869-75. 1996
    ..In normal human breast, the expression of htk, the human homologue, was also confined to the secretory luminal epithelial cells...
  24. ncbi Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis
    Z Nikolova
    Department of Clinical Research, University of Berne, Tiefenaustrasse 120, CH 3004 Berne, Switzerland
    J Cell Sci 111:2741-51. 1998
    ..We have investigated the expression of a member of this family, EphB4, and its cognate ligand, ephrin-B2, during normal and malignant mouse mammary morphogenesis...
  25. ncbi Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells
    Tim Füller
    Department of Vascular Biology and Angiogenesis Research, Institute of Molecular Oncology, Tumor Biology Center, Breisacher Strasse 117, 79106 Freiburg, Germany
    J Cell Sci 116:2461-70. 2003
    ..Recent studies have identified ephrinB2 and EphB4 as markers and makers of arteriovenous differentiation during vascular development...
  26. doi Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts
    Steeve Kwan Tat
    University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Rheum 58:3820-30. 2008
    ..It has been suggested that ephrin B2 and its specific receptor EphB4 participate in bone homeostasis...
  27. ncbi Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily
    B D Bennett
    Genentech, Inc, South San Francisco, California 94080
    J Biol Chem 269:14211-8. 1994
    ..This protein, hepatoma transmembrane kinase or Htk, shares amino acid similarity with the EPH subfamily of tyrosine kinases...
  28. ncbi Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma
    X X Tang
    Division of Oncology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Clin Cancer Res 5:455-60. 1999
    ..In this study, we examined the expression of EPHB1, EPHB2, EPHB3, EPHB4, and EPHB6 in 4 SCLC tumor specimens and 14 cell lines including 3 cell lines derived from these tumor specimens...
  29. ncbi Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusion
    G den Butter
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    Transpl Int 8:466-71. 1995
    ..In this study we compared simpler preservation solutions, namely, histidine-tryptophan-ketoglutarate (HTK) and phosphate-buffered sucrose (PBS) with different compositions of UW solution in the isolated perfused rabbit ..
  30. ncbi Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development
    Chad A Cowan
    Center for Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Dev Biol 271:263-71. 2004
    ..receptors (VEGFR-1 and VEGFR-2) that bind VEGF, the Tie-1 and Tie-2 receptors that bind the angiopoietins, and the EphB4 receptor that binds the membrane-anchored ligand ephrin-B2...
  31. ncbi Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Oncol Rep 8:567-73. 2001
    ..b>EphB4 receptors are a subfamily of receptor tyrosine kinases that are activated by ephrin-B2 ligands and are thought to ..
  32. ncbi Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma
    G Berclaz
    Department of Obstetrics and Gynecology, University Hospital, Berne, Switzerland
    Ann Oncol 14:220-6. 2003
    ..We have observed estrogen-dependent EphB4 expression in the normal breast suggesting its implication in the hormone-controlled homeostasis of this organ...
  33. ncbi Gridlock signalling pathway fashions the first embryonic artery
    T P Zhong
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Nature 414:216-20. 2001
    ..the artery, and expands contiguous regions of the vein, preceded by an increase in expression of the venous marker EphB4 receptor (ephb4) and diminution of expression of the arterial marker ephrin-B2 (efnb2)...
  34. doi Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments
    Timo Wille
    Institut fur Physiologische Chemie, Universitatsklinikum, Essen, Germany
    J Vasc Surg 47:422-31. 2008
    ..Hypothesizing that this iron-dependent cold-induced injury might also occur in the endothelium of intact vessels, we here set out to optimize the hypothermic storage of blood vessels...
  35. pmc Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro
    Shikun He
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Invest Ophthalmol Vis Sci 51:543-52. 2010
    b>EphB4 receptor (EphB4) and its ligand (EphrinB2) play an important role in the regulation of cell adhesion, growth, and migration...
  36. ncbi The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma
    Uttam K Sinha
    Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Arch Otolaryngol Head Neck Surg 132:1053-9. 2006
    To examine the expression of EphB4 in tumor tissue, surrounding normal tissue, and metastatic lymph node in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate its association with disease stage and smoking.
  37. ncbi Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase
    Nadia Munarini
    Department of Clinical Research, University of Berne, Tiefenaustrasse 120, CH 3004 Bern, Switzerland
    J Cell Sci 115:25-37. 2002
    We have previously documented the cell-type-specific and hormone-dependent expression of the EphB4 receptor in the mouse mammary gland...
  38. doi Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells
    Jonathan W Astin
    School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 12:1194-204. 2010
    ..The unimpeded migration of metastatic PC-3 cells towards fibroblasts is dependent on activation of EphB3 and EphB4 by ephrin-B2, which we show activates Cdc42 and cell migration...
  39. ncbi Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breast
    Gilles Berclaz
    Department of Obstetrics and Gynecology, Univeristy Hospital, Inselspital Berne, Schanzeneckstrasse 1, Switzerland
    Oncol Rep 9:985-9. 2002
    ..We have previously demonstrated cell type specific and hormone dependent EphB4 expression in the mouse mammary parenchyma suggesting involvement in the homeostasis of this organ...
  40. pmc Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinoma
    Whitney A Spannuth
    Department of Gynecologic Oncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77230 1439, USA
    Mol Cancer Ther 9:2377-88. 2010
    b>EphB4 is a transmembrane receptor tyrosine kinase that plays an important role in neural plasticity and angiogenesis. EphB4 is overexpressed in ovarian cancer and is predictive of poor clinical outcome...
  41. pmc Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk
    B D Bennett
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 92:1866-70. 1995
    b>Htk is a receptor protein-tyrosine kinase that is related to the EPH subfamily of tyrosine kinases. The receptor has a wide tissue distribution including expression in several myeloid hematopoietic cell lines...
  42. doi Mutagenesis of uracil-DNA glycosylase deficient mutants of the extremely thermophilic eubacterium Thermus thermophilus
    Tomoya Sakai
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    DNA Repair (Amst) 7:663-9. 2008
    ..We then disrupted udgA and udgB by thermostable kanamycin-resistant gene (htk) or pyrE gene insertion in each hisD background, and their spontaneous His(+) reversion frequencies were compared...
  43. doi EphrinB2 and EphB4 expression in pterygia: new insights and preliminary results
    Chunyan Xue
    Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, China
    Can J Ophthalmol 44:185-8. 2009
    ..The ephrin-Eph system, especially ephrinB2 and its receptor EphB4, has been shown to play an important role in tumor angiogenesis...
  44. doi Humanized anti-EphB4 antibodies for the treatment of carcinomas and vasculogenesis-related diseases
    Zenghui Xu
    Zhejiang Sci Tech University, Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Hangzhou, China
    Expert Opin Ther Pat 19:1035-7. 2009
    The invention provides human, humanized or chimeric versions of anti-EphB4 mouse monoclonal antibodies that bind to the human EphB4 receptor tyrosine kinase...
  45. doi Communication between ephrinB2 and EphB4 within the osteoblast lineage
    T J Martin
    Department of Medicine, St Vincent s Institute and University of Melbourne, Melbourne, Fitzroy, 3065, Australia
    Adv Exp Med Biol 658:51-60. 2010
    ..Both a synthetic peptide antagonist of ephrinB2/EphB4 receptor interaction and recombinant soluble extracellular domain of EphB4 (sEphB4), which is an antagonist of ..
  46. doi Structure-based tailoring of compound libraries for high-throughput screening: discovery of novel EphB4 kinase inhibitors
    Peter Kolb
    Department of Biochemistry, University of Zurich, CH 8057 Zurich, Switzerland
    Proteins 73:11-8. 2008
    ..is additionally used here to identify molecules with optimal anchor fragments for the ATP-binding site of the EphB4 receptor tyrosine kinase...
  47. doi In vivo small-animal PET/CT of EphB4 receptors using 64Cu-labeled peptide
    Chiyi Xiong
    Department of Experimental Diagnostic Imaging, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Nucl Med 52:241-8. 2011
    Many solid tumors overexpress EphB4 receptor, a member of the ephrin receptor tyrosine kinase family...
  48. ncbi Paradoxes of the EphB4 receptor in cancer
    Nicole K Noren
    Burnham Institute for Medical Research and Pathology Department, University of California San Diego, La Jolla, California 92037, USA
    Cancer Res 67:3994-7. 2007
    ..This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer...
  49. pmc Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cells
    Michael H Davies
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
    Microvasc Res 77:382-6. 2009
    b>EphB4 receptors and their ephrinB2 ligands are essential for vascular development, but also play a role in pathological neovascularization (NV)...
  50. doi Mammary epithelial-specific knockout of the ephrin-B2 gene leads to precocious epithelial cell death at lactation
    Stéphanie Weiler
    Department of Clinical Research, University of Bern, Tiefenaustrasse 120, Bern, Switzerland
    Dev Growth Differ 51:809-19. 2009
    ..We have previously shown that EphB4 and ephrinB2 are differentially expressed during the development of the adult mammary parenchyma...
  51. doi Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4
    Scott A Mitchell
    Department of Medicinal Chemistry, CGI Pharmaceuticals, Inc, 36 East Industrial Road, Branford, CT 06405, USA
    Bioorg Med Chem Lett 19:6991-5. 2009
    ..b>EphB4, a receptor tyrosine kinase (RTK) involved in the processes of embryogenesis and angiogenesis, has been shown to ..
  52. ncbi Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma
    Anna C Berardi
    Laboratory of Stem Cells, Bambino Gesu Children s Hospital, I 00165 Rome, Italy
    Anticancer Res 28:763-9. 2008
    ..Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated...
  53. ncbi Ability of structurally related polycyclic aromatic carcinogens to induce homologous recombination between duplicated chromosomal sequences in mouse L cells
    N P Bhattacharyya
    Department of Microbiology, Michigan State University, East Lansing 48824 1316
    Mutat Res 211:205-14. 1989
    ..their ability to cause intrachromosomal homologous recombination between two herpes simplex virus thymidine kinase (Htk) genes stably integrated in the genome of a tk- mouse L cell strain 333 M...
  54. ncbi Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells
    N W Gale
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, New York, 10591 6707, USA
    Dev Biol 230:151-60. 2001
    ..molecular marker for the arterial endothelium at the earliest stages of embryonic angiogenesis, while its receptor EphB4 reciprocally marks the venous endothelium...
  55. ncbi Comparative analysis of embryonic gene expression defines potential interaction sites for Xenopus EphB4 receptors with ephrin-B ligands
    P M Helbling
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Dev Dyn 216:361-73. 1999
    ..We describe here the isolation of cDNAs encoding Xenopus EphB4 receptors and show that embryonic expression is prominently associated with the developing vasculature, newly ..
  56. ncbi Ena/VASP proteins mediate repulsion from ephrin ligands
    Iwan R Evans
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 120:289-98. 2007
    ..Moreover, when EphB4 and ephrin-B2 were expressed in neighbouring Swiss 3T3 fibroblasts, VASP and Mena co-accumulated with activated ..
  57. ncbi Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
    S J Holland
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 383:722-5. 1996
    ..Here we show that challenging cells that express the TM ligands Elk-L or Htk-L with the clustered ectodomain of Nuk induces phosphorylation of the ligands on tyrosine, a process that can be ..
  58. ncbi Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations
    Stefanie Diehl
    Max Planck Institut fur Neurobiologie, Martinsried, Germany
    Pediatr Res 57:537-44. 2005
    ..members show a complementary expression pattern in blood vessels, with ephrinB2 being expressed on arterial and EphB4 on venous endothelium...
  59. ncbi Comparison of EphA receptor tyrosine kinases and ephrinA ligand expression to EphB-ephrinB in vascularized corneas
    Takashi Kojima
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL 60612, USA
    Cornea 26:569-78. 2007
    ....
  60. ncbi Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium
    Rizwan Masood
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 105:1310-8. 2005
    ..Ephrin B2 and ephrin B4 (EphB4) are artery- and vein-specific proteins, respectively, with critical roles in vessel maturation...
  61. pmc The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade
    Jeffrey S Scehnet
    Department of Pathology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Blood 113:254-63. 2009
    ..as the induction of EphrinB2, which phenotypically defines arterial endothelial cells and pericytes, and represses EphB4, which defines venous endothelial cells...
  62. doi Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-alpha-acetyl-L-histidine
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 27:208-16. 2008
    ..This screening study tested the effects of iron chelator supplementation in different histidine-tryptophan-ketoglutarate (HTK) organ preservation solutions on endothelial function in a long-term storage model of the isolated rat aorta.
  63. doi Organ preservation with histidine-tryptophan ketogluatarate solution in clinical pancreas transplantation: an update of the indiana university experience
    A Agarwal
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Transplant Proc 40:498-501. 2008
    In May 2003, University of Wisconsin (UW) solution was replaced with Histidine-Tryptophan Ketoglutarate (HTK) solution as the preservation fluid for abdominal organ procurements in our center...
  64. doi Pretreatment with calcitonin gene-related peptide attenuates hepatic ischemia/reperfusion injury in rats
    S W Song
    Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China
    Transplant Proc 41:1493-8. 2009
    ..We sought to investigate the protective effect of calcitonin gene-related peptide (CGRP) to attenuate liver I/R injury due to oxygen free radicals and apoptosis...
  65. ncbi Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators
    U Rauen
    Institut fur Physiologische Chemie, Universitatsklinikum, Hufelandstr 55, 45122, Essen, Germany
    Cell Mol Life Sci 64:192-205. 2007
    ..When cultured hepatocytes were incubated in HTK solution or in modified Krebs-Henseleit buffer containing 198 mM L-histidine at 37 degrees C, most cells lost ..
  66. doi Influence on energy kinetics and histology of different preservation solutions seen during cold ischemia in the liver
    C L Corps
    Transplant Science Group, Department of Hepatology and Transplantation, St James s University Hospital, Leeds West Yorkshire LS9 7TF, United Kingdom
    Transplant Proc 41:4088-93. 2009
    ..over time, using three preservation solutions: University of Wisconsin (UW), histidine-tryptophan-ketoglutarate (HTK), and Leeds solution (LS) under development at our institution...
  67. pmc Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
    E Stein
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 12:667-78. 1998
    Eph family receptor tyrosine kinases (including EphA3, EphB4) direct pathfinding of neurons within migratory fields of cells expressing gradients of their membrane-bound ligands...
  68. ncbi Improving the preservation of isolated rat skeletal muscles stored for 16 hours at 4 degrees C
    E P van der Heijden
    Department of Plastic, Reconstructive and Handsurgery, University Medical Center of Utrecht, The Netherlands
    Transplantation 69:1310-22. 2000
    ..In the present study, we investigated whether muscle preservation during cold storage could be improved by additives that can protect against such processes or by oxygen supply...
  69. ncbi The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers
    Qinghua Wu
    Department of Pathology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Epigenetics 2:237-43. 2007
    ..their promoters, we analyzed the promoter methylation status of three members of the EPHB family, EPHB2, EPHB3 and EPHB4, in a series of 22 colon cancer cell lines, as well as in four ovarian cancer cell lines and 56 ovarian tumor ..
  70. ncbi Preponderance of cells with stem cell characteristics in metastasising mouse mammary tumours induced by deregulated EphB4 and ephrin-B2 expression
    Philip Kaenel
    Department of Clinical Research, University of Bern, Tiefenaustrasse 120c, CH 3004 Bern, Switzerland
    Int J Oncol 38:151-60. 2011
    We have previously shown that EphB4 and ephrin-B2 are differentially expressed in the mammary gland and that their deregulated expression in the mammary epithelium of transgenic mice leads to perturbations of the mammary parenchyma and ..
  71. ncbi Expression of ephrinB2 and its receptors on fibroproliferative membranes in ocular angiogenic diseases
    Naoyasu Umeda
    Department of Ophthalmology, Fukuoka University, School of Medicine, Fukuoka, Japan
    Am J Ophthalmol 138:270-9. 2004
    ..To determine whether ephrinB2 plays a role in ocular angiogenesis, we investigated the expression of ephrinB2 and EphB receptors on retinal fibroproliferative membranes...
  72. doi Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjects
    Sandra C Christiansen
    Southern California Kaiser Permanente Medical Group, San Diego, Calif, USA
    Int Arch Allergy Immunol 147:299-304. 2008
    ..We previously identified human tissue kallikrein (hTK) as the principal lung kininogenase during allergic airway inflammation...
  73. doi Improved vessel preservation after 4 days of cold storage: experimental study in rat arteries
    Birgit Zatschler
    Department of Physiology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany
    J Vasc Surg 50:397-406. 2009
    ..Cold storage of arteries for reconstructive and bypass surgery may result in injury of endothelial cells which may promote low perfusion and graft vasculopathy...
  74. ncbi Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene
    K Ikenaka
    National Institute for Physiological Sciences, Okazaki National Research Institutes
    Hum Cell 14:49-58. 2001
    We prepared retroviruses carrying the lacZ gene or herpes simplex virus thymidine kinase (HTK) gene with titers of 1.4-2...
  75. ncbi Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia
    Costanza Emanueli
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Front Biosci 12:2003-12. 2007
    ..we have tested the therapeutic potential of local angiogenesis gene therapy with human tissue kallikrein (hTK) or constitutively-activated Akt kinase (Myr-Akt)...
  76. pmc Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis
    Yung Hae Kim
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Development 135:3755-64. 2008
    ..Loss of ephrin B2 or its receptor EphB4 also leads to enlarged aortae and underdeveloped cardinal veins; however, endothelial cells with venous identity ..
  77. ncbi Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck
    Machiko Kimura
    Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Yokohama 236 0004, Japan
    Int J Oncol 34:321-7. 2009
    The ephB4-ephrinB2 system plays an important role in the interaction of tumor cells with endothelial cells (ECs)...
  78. ncbi Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors
    R Brambilla
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell Neurosci 8:199-209. 1996
    ..The common receptors Cek10 and Elk bind and signal in response to Lerk2 and Elf2, whereas the Myk1 receptor is specific for Elf2...
  79. ncbi [Perfusion strategies of extracorporeal circulation for robotically assisted cardiac surgery]
    Jia li Wang
    Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2300-1. 2009
    ..To discuss the management of extracorporeal circulation (ECC) for robotically assisted cardiac surgery...
  80. ncbi The relationship between oncogene expression and clinical outcome in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita, 879 5593, Japan
    Curr Cancer Drug Targets 4:511-20. 2004
    ..Scoring on the basis of the percentage of positive cells indicated that Plks, EphB4, ephrin-B2, Id1, CaMKIV, c-Ets1, Elf-1, and survivin expression were significantly associated with PCNA-labeling ..
  81. ncbi Origin, differentiation, and maturation of human pulmonary veins
    Susan M Hall
    Unit of Vascular Biology and Pharmacology, Institute of Child Health, University College, London, United Kingdom
    Am J Respir Cell Mol Biol 26:333-40. 2002
    ..and desmin) and antibodies specific for the matrix glycoprotein tenascin, the receptor protein tyrosine kinase EphB4, and its ligand ephrinB2...
  82. ncbi Eurotransplant randomized multicenter kidney graft preservation study comparing HTK with UW and Euro-Collins
    J de Boer
    Eurotransplant International Foundation, Leiden, The Netherlands
    Transpl Int 12:447-53. 1999
    The aim was to evaluate the effect of HTK compared to UW and Euro-Collins (EC) on the initial graft function and long term graft survival in two prospective randomized studies...
  83. ncbi Selective expression of the receptor tyrosine kinase, HTK, on human erythroid progenitor cells
    T Inada
    Department of Cell Differentiation, Kumamoto University School of Medicine, Kumamoto City, Japan
    Blood 89:2757-65. 1997
    b>HTK is a receptor tyrosine kinase of the Eph family. To characterize the involvement of HTK in hematopoiesis, we generated monoclonal antibodies against HTK and investigated its expression on human bone marrow cells...
  84. doi Targeting the DFG-in kinase conformation: a new trend emerging from a patent analysis
    Mauro Angiolini
    Medicinal Chemistry Department, Oncology Business Unit, Nerviano Medical Sciences, 20014 Nerviano, Italy
    Future Med Chem 3:309-37. 2011
    ..by the so-called 'Type I½' inhibitor, against a small set of clinically relevant targets such as B-Raf, p38α, Jak2 and EphB4. Preclinical and clinical data are also highlighted for the most promising new molecular entities.
  85. ncbi Impact of the incubation medium on the endothelium of autologous vein grafts: damage scoring by scanning electron microscopy
    M A Konerding
    Department of Macroscopic Anatomy, University of Mainz, Germany
    Scanning Microsc 10:841-8; discussion 848-9. 1996
    ..served as controls; the others were assigned to test groups and exposed to heparinized whole blood, Bretschneider's HTK, human albumin or Ringer's solution...
  86. ncbi In vitro function of porcine carotid arteries preserved in UW, HTK and Celsior solutions
    S T L Abrahamse
    Department of Surgery Surgical Laboratory, Academic Medical Center, The University of Amsterdam, The Netherlands
    Fundam Clin Pharmacol 16:503-11. 2002
    We compared the efficacy of histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solution with Celsior solution using hypothermically-preserved porcine carotid arteries and studied the importance of different ..
  87. ncbi Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantation
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Transplantation 77:1304-6. 2004
    ..This study assesses the efficacy of histidine-tryptophan-ketoglutarate (HTK) compared with UW in pancreas transplantation.
  88. ncbi Wash-out of the non-heart-beating donor liver: a comparison between ringer lactate, HTK, and polysol
    M Bessems
    Surgical Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Transplant Proc 37:395-8. 2005
    The solution of choice for wash-out of non-heart-beating donor (NHBD) livers is histidine tryptophan ketoglutarate (HTK)...
  89. ncbi Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity
    Jill E Chrencik
    Department of Cellular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Structure 14:321-30. 2006
    ..We report the crystal structure of the EphB4 receptor in complex with a highly specific antagonistic peptide at a resolution of 1.65 angstroms...
  90. pmc EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling
    Ombretta Salvucci
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 108:2914-22. 2006
    ..We describe how endogenous EphB2 and EphB4 signaling are required for the formation of extracellular matrix-dependent capillary-like structures in primary ..
  91. ncbi Preclinical evaluation of coronary vascular function after cardioplegia with HTK and different antioxidant additives
    Cornelia Schröder
    Institute of Physiology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany
    Eur J Cardiothorac Surg 31:821-6. 2007
    ..Due to limited resources, improvement of preservation solutions is still of great importance in cardiac transplant surgery. New additives with antioxidant properties were tested with respect to coronary function of isolated rat hearts...
  92. ncbi Evaluation of a novel cold storage solution (HBs) in a rat kidney transplant model
    Fernando Lopez-Neblina
    Discovery Research Laboratories, Human Biosystems Michigan Branch, Vicksburg, Michigan, USA
    J Invest Surg 20:257-63. 2007
    ..The animals were divided into three groups based upon the preservation solution utilized: HBS solution, HTK solution (Custodiol), and UW solution (UWS)(ViaSpan). Among the recipients, each group had two subsets...
  93. ncbi Electrical impedance of the liver during experimental long-term liver preservation
    P Cascales-Sanchez
    Service of General Surgery, Albacete Universitary General Hospital, Albacete, Spain
    Transplant Proc 39:2118-9. 2007
    ..rabbit liver during long-term preservation with University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solution...
  94. doi Osteoclast-osteoblast communication
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
    Arch Biochem Biophys 473:201-9. 2008
    ..Bidirectional signaling generated by interaction between ephrinB2 on osteoclasts and EphB4 on osteoblast precursors facilitates the transition...
  95. doi Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in adult liver transplantation
    F Rayya
    Clinic for Visceral, Transplantation, Thoracic and Vascular Surgery, University Leipzig, Leipzig, Germany
    Transplant Proc 40:891-4. 2008
    A safe and effective preservation solution is a precondition for successful orthotopic liver transplantation (OLT). This study compared University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions in OLT.
  96. doi Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in intestinal and multivisceral transplantation
    Richard S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Transplantation 86:298-302. 2008
    Previous studies have failed to demonstrate a clinical difference between histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) preservation solutions in clinical transplant outcomes for liver, pancreas, and kidney ..
  97. doi Organ preservation solutions attenuate accumulation and nuclear translocation of hypoxia-inducible factor-1alpha in the hepatoma cell line HepG2
    Renate Paddenberg
    Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Cell Biochem Funct 27:516-25. 2009
    ..we determined the impact of organ preservation solutions (Celsior; histidine-tryptophan-ketoglutarate solution, HTK; University of Wisconsin solution; UW), oxygen supply, and temperature on HIF-1alpha accumulation, recorded by ..
  98. doi BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4
    Momoko Suzuki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Eur J Haematol 84:229-38. 2010
    ..We investigated the mechanism responsible for imatinib (IM) resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) cell lines...
  99. doi Assessment of buffer systems for harvesting proteins from tissue interstitial fluid for proteomic analysis
    Pang Ning Teng
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA
    J Proteome Res 9:4161-9. 2010
    ..three organ transplantation preservative solutions: Celsior solution S (CS), histidine-tryptophan-ketoglutarate (HTK), and University of Wisconsin (UW)...
  100. doi One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study
    Bjørn Braathen
    Department of Cardiothoracic Surgery, Oslo University Hospital Ulleval, Oslo, Norway
    J Thorac Cardiovasc Surg 141:995-1001. 2011
    Histidine-tryptophan-ketoglutarate (HTK-Custodiol) cardioplegic solution is administered as one single dose for more than 2 hours of ischemia...
  101. doi Complementary expression of EphB receptors and ephrin-B ligand in the pyloric and duodenal epithelium of adult mice
    Maki Ishii
    Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Japan
    Histochem Cell Biol 136:345-56. 2011
    ..In contrast, EphB2, EphB3, and EphB4 were expressed in pyloric glandular cells and proliferating cells of the isthmus...

Research Grants36

  1. The EphB4 Receptor as a Novel Breast Cancer Target
    Elena B Pasquale; Fiscal Year: 2010
    Receptor tyrosine kinases of the Eph family are upregulated in different types of cancer. EphB4 has been linked to breast cancer and other types of cancer, but little is known about how this receptor may contribute to oncogenesis...
  2. EphB4 Receptor Tyrosine Kinase RTK Targeted Humanized Monoclonal Antibody h131
    VALERY G KRASNOPEROV; Fiscal Year: 2012
    ..studies will be performed in addition to those already done to determine if Kras mutant tumors or tumors with EphB4 gene amplification are more susceptible to h131 treatment measured by tumor regression instead of reduction in the ..
  3. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..Based on preliminary expression data, EphB4, an important receptor for ephrin-B2 is highly expressed within the palate during its formation...
  4. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..Based on preliminary expression data, EphB4, an important receptor for ephrin-B2 is highly expressed within the palate during its formation...
  5. Structural determinants of promiscuity and selectivity iin Ephrin_Eph binding.
    Peter Kuhn; Fiscal Year: 2010
    ..interfaces across the family, including highly promiscuous receptors (EphB2, EphA4) and highly specific receptors (EphB4, EphA2)...
  6. sEphB4-HSA A Pre-Clinical Candidate for Oncology
    VALERY G KRASNOPEROV; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This is aimed at the pre-clinical development of soluble EphB4-HSA (sEphB4-HSA) and its ultimate commercialization for the treatment of various cancer types...
  7. EphB4 as Novel Target for Breast Cancer Imaging
    PETER STEPHEN CONTI; Fiscal Year: 2012
    ..In particular, up-regulation of EphB4 expression has been found in mouse mammary tumor models and in more than half of the human breast cancer specimens ..
  8. Candece L Gladson; Fiscal Year: 2016
    ..molecule ephrin-B2 on the ECs based on array analysis and blocking studies using recombinant ephrin-B2-Fc and EphB4-Fc (the ephrin-B2 receptor)...
  9. VALERY G KRASNOPEROV; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): During embryonic development, EphB4 and EphrinB2 are both critically required for maturation of newly forming blood vessels. EphrinB2 and is critically required for activation of VEGFR2/3...
  10. Novel Role of Corneal Crystallins as Modulators of Cell Growth and Transparency
    Vasilis Vasiliou; Fiscal Year: 2011
    ..Human corneal epithelial and keratocyte telomerase immortalized cell lines (hTCepi and hTK) will be stably transfected with a tetracycline-inducible mammalian expression vector carrying cDNAs of wild type ..
  11. Host Vascular Mechanism for Therapeutic Protection against Select Pathogens
    Joanne Chan; Fiscal Year: 2013
    ..current knowledge on 3 key angiogenic factors and their receptors, VEGF-A/VEGFR2, Angiopoietin 1/Tie2 and ephrinB2/EphB4, to establish reliable models for vascular integrity...
  12. Zibo Li; Fiscal Year: 2016
    ..approach that for pretargeted imaging/radioimmunotherapy of cancer based on the tetrazine-TCO ligation and anti-EphB4 antibody...
  13. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
    ..This will be accomplished using several new adenoviruses designed to antagonize the TIE/angiopoietin and EphB4/ephrin-B2 endothelial receptor tyrosine kinase pathways...
  14. A new approach to the treatment of Retinopathy of Prematurity
    Paul A Yates; Fiscal Year: 2013
    ..Specific Aim III is to determine whether two molecules involved in blood vessel growth, ephrin-B2 and EphB4, are involved in ROP and if they might be a good target to treat the disease.
  15. Ephrins and Repeated Cocaine
    Robert Pierce; Fiscal Year: 2006
    ..In mammals, eight ephrins (ephrinA1-ephrinA5; ephrinB1-ephrinB3) and thirteen Eph receptors (EphA1-EphA8; EphB1-EphB4, EphB6) have been identified to date...
  16. Genomic Instability and Etiology of Estrogen Oncogenesis
    Jonathan Li; Fiscal Year: 2007
    ..and aneuploidy in a unique, but relevant animal tumor model, the E-induced malignant tumors in the hamster kidney (HTK). SPECIFIC AIM 1...
  17. GENETIC ANALYSIS OF EPHRIN-EPH SIGNALING IN ANGIOGENESIS
    David Anderson; Fiscal Year: 2005
    ..expressed by arterial but not venous endothelial cells in both embryos and adults, whereas its receptor EphB4 is conversely expressed by veins but not arteries...
  18. The Role of Mast Cells in Tumor Angiogenesis
    Darya Soto; Fiscal Year: 2006
    ..mast cells and endothelial cells in the development of tumor angiogenesis, in particular the role of ephrinB2 and EphB4 in this process. EphB4 is one member of a receptor tyrosine kinase family, and its co-receptor is ephrinB2...
  19. EphB4 modulates hemangioblast development
    Zack Wang; Fiscal Year: 2007
    ..Endothelial cell receptor tyrosine kinase EphB4 (HTK) and its ligand, ephrinB2, are critical for angiogenesis...
  20. DongBao Chen; Fiscal Year: 2016
    ..These studies are relevant to uncover the dilemma of the cardiovascular protective effects of estrogen. ..
  21. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  22. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  23. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  24. Effects of the Mevalonate Pathway on Bone Formation
    Gregory Mundy; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. EphA2 Agonists as Novel Inhibitors of Tumor Progression
    Bingcheng Wang; Fiscal Year: 2007
    ..Completion of the proposed studies can lead to new mechanism-based therapeutic agents and strategies for prostate cancer. ..
  26. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  27. Eph Kinase Signaling in Prostate Cancer
    Bingcheng Wang; Fiscal Year: 2004
    ....
  28. TRAINING PROGRAM IN BONE AND MINERAL METABOLISM
    Gregory Mundy; Fiscal Year: 2002
    ..Of the trainees supported by the NIH Institutional Training Grant, we have had 25 graduates, 18 of whom are in full-time academic/ research careers. ..
  29. Gli Control of PTH-rP and Osteolysis in Breast Cancer
    Gregory Mundy; Fiscal Year: 2009
    ..We propose therefore that the Gli family of transcriptional regulators represents an important molecular pathway that regulates PTH-rP expression in breast cancer cells, and subsequent breast cancer-mediated osteolysis. ..
  30. VEGFs in Artery-Vein Imbalance in AIDS-Kaposi Sarcoma
    Parkash Gill; Fiscal Year: 2009
    ..proteins which mark this distinction are ephrin B2, expressed on arterial endothelial cells, and its receptor, EphB4, which is expressed on venous endothelial cells...
  31. THE UBIQUITIN-PROTEOSOME PATHWAY AND BMP-2 EXPRESSION
    Gregory Mundy; Fiscal Year: 2008
    ..abstract_text> ..
  32. Caveolin-1, Caveolae and Placental Angiogenesis
    DongBao Chen; Fiscal Year: 2007
    ....
  33. EMAP II Regulation of Pulmonary Cell Proliferation
    MARGARET SCHWARZ; Fiscal Year: 2007
    ..abstract_text> ..
  34. Vasculature is a determinant of epithelial morphogenesis
    MARGARET SCHWARZ; Fiscal Year: 2006
    ..Thus, identifying the factors responsible for coordinating vascular formation and distal lung morphogenesis will provide insight into the determinants by which their balance can affect lung development. ..
  35. IVth Intl Conference on Cancer-Induced Bone Diseases
    Gregory Mundy; Fiscal Year: 2004
    ..Attention will also be given to current diagnostic methods for patients with these skeletal complications of malignancy. ..