EPCAM

Summary

Gene Symbol: EPCAM
Description: epithelial cell adhesion molecule
Alias: DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, epithelial cell adhesion molecule, adenocarcinoma-associated antigen, cell surface glycoprotein Trop-1, epithelial glycoprotein 314, human epithelial glycoprotein-2, major gastrointestinal tumor-associated protein GA733-2, membrane component, chromosome 4, surface marker (35kD glycoprotein), tumor-associated calcium signal transducer 1
Species: human

Top Publications

  1. ncbi Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter
    Olivier Gires
    Clinical Cooperation Group Molecular Oncology, GSF Research Center for Health and Environment, Department of Otorhinolaryngology, Ludwig Maximilians University, Marchioninistr 15, D 81377 Munich, Germany
    Anticancer Res 23:3255-61. 2003
  2. ncbi Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)
    J M Chong
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:5804-13. 2001
  3. pmc Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2
    S Szala
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 87:3542-6. 1990
  4. ncbi Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival
    Meri Varga
    Division of Hematology and Oncology, University of Innsbruck, Innsbruck, Austria
    Clin Cancer Res 10:3131-6. 2004
  5. ncbi The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7
    Markus Ladwein
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Exp Cell Res 309:345-57. 2005
  6. doi Overexpression of epithelial cell adhesion molecule in primary, metastatic, and recurrent/chemotherapy-resistant epithelial ovarian cancer: implications for epithelial cell adhesion molecule-specific immunotherapy
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Int J Gynecol Cancer 19:860-6. 2009
  7. pmc Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells
    Tung Ying Lu
    Institute of Cellular and Organismic Biology, Consiglio Nazionale delle Ricerche, Milan 20131, Italy
    J Biol Chem 285:8719-32. 2010
  8. pmc Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion
    Narendra V Sankpal
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St, Louis, Missouri 63110, USA
    Breast Cancer Res 13:R124. 2011
  9. pmc Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins
    S V Litvinov
    Department of Pathology, Leiden University, Leiden 2300 RC, The Netherlands
    J Cell Biol 139:1337-48. 1997
  10. ncbi Epithelial cell adhesion molecule (KSA) expression: pathobiology and its role as an independent predictor of survival in renal cell carcinoma
    David B Seligson
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, California 90095, USA
    Clin Cancer Res 10:2659-69. 2004

Research Grants

  1. David Kuhrt; Fiscal Year: 2015
  2. Anna Rita F Migliaccio; Fiscal Year: 2015
  3. Adam E Gaweda; Fiscal Year: 2015
  4. MEREDITH ANN ATKINSON; Fiscal Year: 2015
  5. Do Safety Warnings Change Prescribing among the US Dialysis Population?
    Mae Thamer; Fiscal Year: 2012
  6. Comparative Effectiveness and Safety of Newer Agents for Anemia Treatment in HD
    WOLFGANG CHRISTOPH WINKELMAYER; Fiscal Year: 2013
  7. Yossi Chait; Fiscal Year: 2016
  8. Erythropoiesis-stimulating agent use among chronic kidney disease patients
    DENNIS JOSEPH COTTER; Fiscal Year: 2012
  9. DENNIS JOSEPH COTTER; Fiscal Year: 2014
  10. Robin K Ohls; Fiscal Year: 2014

Patents

  1. Methods vectors plasmids and methods for increasing expression ofrecombinant polypeptides

Detail Information

Publications222 found, 100 shown here

  1. ncbi Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter
    Olivier Gires
    Clinical Cooperation Group Molecular Oncology, GSF Research Center for Health and Environment, Department of Otorhinolaryngology, Ludwig Maximilians University, Marchioninistr 15, D 81377 Munich, Germany
    Anticancer Res 23:3255-61. 2003
    The epithelial cell adhesion molecule (EpCAM) is a transmembrane protein associated with a variety of carcinomas, where EpCAM is often strongly up-regulated or, as in the case of squamous cell carcinomas, de novo expressed...
  2. ncbi Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)
    J M Chong
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:5804-13. 2001
    ....
  3. pmc Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2
    S Szala
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 87:3542-6. 1990
    ..At the amino acid sequence level, GA733-2 was found to be greater than 99% identical to the previously described KSA antigen defined by monoclonal antibody KS1/4...
  4. ncbi Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival
    Meri Varga
    Division of Hematology and Oncology, University of Innsbruck, Innsbruck, Austria
    Clin Cancer Res 10:3131-6. 2004
    ..This retrospective study was designed to investigate the prognostic significance of epithelial cell adhesion molecule (Ep-CAM) overexpression in human gallbladder carcinoma.
  5. ncbi The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7
    Markus Ladwein
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Exp Cell Res 309:345-57. 2005
    ..described that in the metastasizing rat pancreatic carcinoma line BSp73ASML the cell-cell adhesion molecule EpCAM, CD44 variant isoforms and the tetraspanins D6...
  6. doi Overexpression of epithelial cell adhesion molecule in primary, metastatic, and recurrent/chemotherapy-resistant epithelial ovarian cancer: implications for epithelial cell adhesion molecule-specific immunotherapy
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Int J Gynecol Cancer 19:860-6. 2009
    To evaluate the potential of epithelial cell adhesion molecule (Ep-CAM/TROP-1)-specific immunotherapy against epithelial ovarian carcinomas (EOCs), we have analyzed the expression of Ep-CAM at RNA and protein level in patients harboring ..
  7. pmc Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells
    Tung Ying Lu
    Institute of Cellular and Organismic Biology, Consiglio Nazionale delle Ricerche, Milan 20131, Italy
    J Biol Chem 285:8719-32. 2010
    ..To date, more cell surface markers capable of reliably identifying hESCs are needed. The epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein expressed in several progenitor cell populations and ..
  8. pmc Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion
    Narendra V Sankpal
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St, Louis, Missouri 63110, USA
    Breast Cancer Res 13:R124. 2011
    b>EpCAM is a cell-surface glycoprotein that is overexpressed in the majority of epithelial carcinomas...
  9. pmc Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins
    S V Litvinov
    Department of Pathology, Leiden University, Leiden 2300 RC, The Netherlands
    J Cell Biol 139:1337-48. 1997
    ....
  10. ncbi Epithelial cell adhesion molecule (KSA) expression: pathobiology and its role as an independent predictor of survival in renal cell carcinoma
    David B Seligson
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, California 90095, USA
    Clin Cancer Res 10:2659-69. 2004
    b>Epithelial cell adhesion molecule (EpCAM) is a widely expressed adhesion molecule in epithelial cancers...
  11. ncbi The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
    Markus Munz
    Clinical Cooperation Group Molecular Oncology, GSF National Research Center for Environment and Health, and Department of Otorhinolaryngology, Ludwig Maximilians University, Marchioninistr 15, Munich D 81377, Germany
    Oncogene 23:5748-58. 2004
    b>Epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein expressed on adenomatous and simple epithelia, where it is involved in homophilic adhesion at the basolateral membrane...
  12. ncbi MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection
    Yoshihiro Hamada
    Department of Pathology, School of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Cancer Lett 243:211-6. 2006
    ..0097) and Kaplan-Meier curves showed a significant relationship with increased overall survival (P=0.0137). These results suggest that MK-1 expression is a prognostic marker of CAV...
  13. ncbi Prognostic significance of EpCAM expression in human esophageal cancer
    Hitoshi Kimura
    Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Oncol 30:171-9. 2007
    b>EpCAM is a 40-kDa epithelial transmembrane glycoprotein that has a well-known role in Ca2+ -independent homophilic cell-cell adhesion...
  14. ncbi Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment
    Willemijn M Gommans
    Department of Therapeutic Gene Modulation, University of Groningen, Groningen, The Netherlands
    Mol Carcinog 46:391-401. 2007
    ..Overall, ZFP-TFs are versatile bi-directional modulators of gene expression and downregulation of EGP-2 promoter activity using ZFP-TFs can ultimately result in a novel anti-cancer treatment...
  15. ncbi A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression
    Sebastian Kuhn
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Im Neuenheimer Feld, 280 D 69120 Heidelberg, Germany
    Mol Cancer Res 5:553-67. 2007
    High expression of EpCAM and the tetraspanin CO-029 has been associated with colorectal cancer progression. However, opposing results have been reported on CD44 variant isoform v6 (CD44v6) expression...
  16. ncbi EpCAM expression in normal, non-pathological tissues
    Eva Schmelzer
    Leipzig University, Biotechnological Biomedical Center, Department of Cell Culture and Stem Cell Biology, Deutscher Platz 5, 04103 Leipzig, Germany
    Front Biosci 13:3096-100. 2008
    b>Epithelial Cell Adhesion Molecule (EpCAM) is a transmembrane glycoprotein that is associated with various cancers...
  17. ncbi Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Cancer Res 67:10831-9. 2007
    ..cells with the activation of stem cell markers and Wnt-beta-catenin signaling, based on EpCAM (epithelial cell adhesion molecule, a hepatic stem cell marker) expression...
  18. doi Expression of epithelial cell adhesion molecule in gallbladder carcinoma and its correlation with clinicopathologic variables
    Sagit Prince
    Department of Internal Medicine B, Rabin Medical Center, Petach Tikva
    Am J Clin Pathol 129:424-9. 2008
    Gallbladder carcinoma is rare and fatal, and conventional therapies have been disappointing. Epithelial cell adhesion molecule (EpCAM) serves as a prognostic marker in various carcinomas and is a target of antibody-based therapies...
  19. doi EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:1451-61. 2008
    ..Recently, we have identified that a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM), may serve as an early biomarker of HCC because its expression is highly elevated in ..
  20. ncbi Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM
    Markus Munz
    Clinical Cooperation Group Molecular Oncology, GSF Research Center for Environment and Health, and Head and Neck Research Dept Munich, Germany
    Front Biosci 13:5195-201. 2008
    b>Epithelial cell adhesion molecule EpCAM is strongly over-expressed in a variety of carcinomas where it is involved in signalling events resulting in increased expression of target genes such as c-Myc, cyclins and others, eventually ..
  21. doi Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1)
    Carlo Patriarca
    Department of Pathology, Azienda Ospedaliera di Melegnano, and University of Milan Medical School, ICH Humanitas Rozzano, Milan, Italy
    Int J Surg Pathol 17:99-106. 2009
    ..Finally, Ep-CAM expression might provide some support for future target therapy trials...
  22. doi On the abundance of EpCAM on cancer stem cells.
    Olivier Gires
    Nat Rev Cancer 9:143; author reply 143. 2009
  23. doi Nuclear signalling by tumour-associated antigen EpCAM
    Dorothea Maetzel
    Clinical Cooperation Group Molecular Oncology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, and Head and Neck Research Dept, Ludwig Maximilians University of Munich, Germany
    Nat Cell Biol 11:162-71. 2009
    b>EpCAM was found to be overexpressed on epithelial progenitors, carcinomas and cancer-initiating cells. The role of EpCAM in proliferation, and its association with cancer is poorly explained by proposed cell adhesion functions...
  24. pmc Transcriptional repression of epithelial cell adhesion molecule contributes to p53 control of breast cancer invasion
    Narendra V Sankpal
    Section of Endocrine and Oncologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:753-7. 2009
    ..Recent evidence suggests that p53 may also contribute to the regulation of migration and invasion. Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that is overexpressed in the majority of human epithelial ..
  25. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
    ..We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer cells with stem/progenitor features...
  26. doi EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer
    Du Wenqi
    State Key Laboratory of Cancer Biology, Digestive Diseases of Xijing Hospital, Fourth Military Medical University, 710032 Xi an, Shaanxi Province, People s Republic of China
    J Cancer Res Clin Oncol 135:1277-85. 2009
    To identify the role of epithelial cellular adhesion molecule (EpCAM) in gastric cancer growth and explore the potential value of EpCAM monoclonal antibody as new therapeutic strategy for gastric cancer.
  27. doi The emerging role of EpCAM in cancer and stem cell signaling
    Markus Munz
    Micromet AG, Munich, Germany
    Cancer Res 69:5627-9. 2009
    Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies...
  28. pmc Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 50:472-80. 2009
    ..Recently, we have identified a subset of highly invasive epithelial cell adhesion molecule (EpCAM)(+) HCC cells from alpha-fetoprotein (AFP)(+) tumors with cancer stem/progenitor cell ..
  29. doi Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells
    Valerie Y Ng
    Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, Biopolis, Singapore 138668, Singapore
    Stem Cells 28:29-35. 2010
    ..In this study, we have identified the antigen target of one such monoclonal antibody as the epithelial cell adhesion molecule (EpCAM)...
  30. pmc Identification of EpCAM as a molecular target of prostate cancer stroma
    Sumana Mukherjee
    Pathogenetics Unit, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
    Am J Pathol 175:2277-87. 2009
    ..Since the stromal compartment may be particularly accessible to vascular-delivered agents, epithelial cell adhesion activating molecule could become a valuable molecular target for imaging or treatment of prostate cancer...
  31. pmc Initial activation of EpCAM cleavage via cell-to-cell contact
    Sabine Denzel
    Clinical Cooperation Group Molecular Oncology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, and Head and Neck Research Dept, Ludwig Maximilians University of Munich, Germany
    BMC Cancer 9:402. 2009
    b>Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein, which is frequently over-expressed in simple epithelia, progenitors, embryonic and tissue stem cells, carcinoma and cancer-initiating cells...
  32. doi Increased EpCAM expression in malignant insulinoma: potential clinical implications
    Andreas Raffel
    Department of General, Institute of Pathology, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Eur J Endocrinol 162:391-8. 2010
    b>EpCAM (CD326) is overexpressed in progenitor cells of endocrine pancreatic islands of Langerhans during fetal development and was suggested to act as a morphoregulatory molecule in pancreatic island ontogeny...
  33. doi Angiogenesis and clinicopathologic characteristics in different hepatocellular carcinoma subtypes defined by EpCAM and α-fetoprotein expression status
    Yun Feng Shan
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China
    Med Oncol 28:1012-6. 2011
    Recently, two hepatic lineage markers epithelial cell adhesion molecule (EpCAM) and α-fetoprotein (AFP) were used to classify hepatocellular carcinoma (HCC) into four subtypes with prognostic implication...
  34. pmc EpCAM nuclear localization identifies aggressive thyroid cancer and is a marker for poor prognosis
    Ranju Ralhan
    Department of Otolaryngology, Head and Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G1X5, Canada
    BMC Cancer 10:331. 2010
    Proteolytic cleavage of the extracellular domain (EpEx) of Epithelial cell adhesion molecule (EpCAM) and nuclear signaling by its intracellular oncogenic domain Ep-ICD has recently been implicated in increased proliferation of cancer ..
  35. pmc Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
    A Lugli
    Institute of Pathology, University of Basel, Basel, Switzerland
    Br J Cancer 103:382-90. 2010
    The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer.
  36. doi A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population
    Lan Jiang
    The Institute of Biology and Medical Sciences, Medical College of Soochow University, 215123, Suzhou, China
    Breast Cancer Res Treat 126:487-95. 2011
    As a tumor-associated antigen and a surface marker of breast cancer stem cells (BCSCs), epithelial cell adhesion molecule (EpCAM) plays an important role in not only cell adhesion, morphogenesis, metastases but also carcinogenesis...
  37. doi Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines
    Osamu Kimura
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 101:2145-55. 2010
    Accumulating evidence suggests that cancer stem cells (CSC) play an important role in tumorigenicity. Epithelial cell adhesion molecule (EpCAM) is one of the markers that identifies tumor cells with high tumorigenicity...
  38. pmc Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110
    Silke Petsch
    Micromet Inc, Bethesda, MD, USA
    MAbs 3:31-7. 2011
    ..Recently, epithelial cell adhesion molecule (EpCAM) has been shown to be activated by release of its ectodomain, called EpEX...
  39. pmc Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
    Marlies J E Kempers
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet Oncol 12:49-55. 2011
    ..We previously showed that constitutional 3' end deletions of EPCAM can cause Lynch syndrome through epigenetic silencing of MSH2 in EPCAM-expressing tissues, resulting in tissue-..
  40. pmc Nuclear and cytoplasmic accumulation of Ep-ICD is frequently detected in human epithelial cancers
    Ranju Ralhan
    Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Department of Otolaryngology Head and Neck Surgery Program, Mount Sinai Hospital, University of Toronto Medical School, Department of Otolaryngology Head and Neck Surgery, Toronto, Ontario, Canada
    PLoS ONE 5:e14130. 2010
    ..demonstrated that nuclear and cytoplasmic accumulation of the intracellular domain (Ep-ICD) of epithelial cell adhesion molecule (EpCAM) accompanied by a reciprocal reduction of its extracellular domain (EpEx), occurs in ..
  41. pmc Effects of EpCAM overexpression on human breast cancer cell lines
    Johanna M Gostner
    Laboratory for Experimental Oncology, Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria
    BMC Cancer 11:45. 2011
    Recently, EpCAM has attracted major interest as a target for antibody- and vaccine-based cancer immunotherapies...
  42. pmc EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis
    Gilbert Spizzo
    Laboratory for Experimental Oncology Tyrolean Cancer Research Institute, Innsbruck Medical University, Innsbruck, Austria
    J Clin Pathol 64:415-20. 2011
    b>Epithelial cell adhesion molecule (EpCAM) is a cell surface protein with oncogenic features that is expressed on healthy human epithelia and corresponding malignant tumours...
  43. doi Impact of the EpCAM expression on biochemical recurrence-free survival in clinically localized prostate cancer
    Goran Benko
    Department of Urology, VaraZdin General Hospital, Varazdin, Croatia
    Urol Oncol 31:468-74. 2013
    The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin...
  44. doi Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage
    Anne Kathleen Rupp
    Tumor Immunology Programme, D015, German Cancer Research Center, D 69120 Heidelberg, Germany
    Gynecol Oncol 122:437-46. 2011
    ..However, marker proteins that allow enrichment of tumor-derived exosomes over normal exosomes are less well defined...
  45. pmc Transcription factors and molecular epigenetic marks underlying EpCAM overexpression in ovarian cancer
    B T F van der Gun
    Epigenetic Editing, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Br J Cancer 105:312-9. 2011
    The epithelial cell adhesion molecule (EpCAM) is overexpressed on carcinomas, and its downregulation inhibits the oncogenic potential of multiple tumour types...
  46. doi EpCAM regulates cell cycle progression via control of cyclin D1 expression
    A Chaves-Pérez
    Clinical Cooperation Group Molecular Oncology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, and Head and Neck Research Department, Ludwig Maximilians University of Munich, Munich, Germany
    Oncogene 32:641-50. 2013
    The epithelial cell adhesion molecule (EpCAM) is an integral transmembrane protein that is frequently overexpressed in embryonic stem cells, tissue progenitors, carcinomas and cancer-initiating cells...
  47. pmc Oncogenic microRNA 17-92 cluster is regulated by epithelial cell adhesion molecule and could be a potential therapeutic target in retinoblastoma
    Moutushy Mitra Kandalam
    Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India
    Mol Vis 18:2279-87. 2012
    ..The miR 17-92 cluster located in 13q31 locus might contribute to retinoblastoma (RB) oncogenesis as 13q31 is amplified often in RB. We attempted to identify the factors involved in the regulation of miR 17-92 cluster in RB...
  48. pmc Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer
    Cheng Wei Lin
    Institute of Cellular Organismic Biology, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 287:39449-59. 2012
    b>Epithelial cell adhesion molecule (EpCAM) is highly expressed in epithelial-transformed neoplasia and tumor-initiated cells (TICs), but the role that EpCAM plays in the stemness properties of TICs is still unclear...
  49. doi Expression and role of epithelial cell adhesion molecule in dysplastic nodule and hepatocellular carcinoma
    Jun Sang Bae
    Department of Pathology, Chonbuk National University, Medical School, and Research Institute for Endocrine Sciences, Jeonju, Republic of Korea
    Int J Oncol 41:2150-8. 2012
    b>Epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC)...
  50. doi Cytoplasmic Trop-1/Ep-CAM overexpression is associated with a favorable outcome in node-positive breast cancer
    Saverio Alberti
    Department of Clinical and Community Health Sciences, Medical Statistics, Biometry and Bioinformatics, University of Milan, Via Vanzetti 5, 20133 Milan, Italy
    Jpn J Clin Oncol 42:1128-37. 2012
    ..Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells...
  51. pmc Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines
    Agnieszka Martowicz
    Laboratory of Experimental Oncology, Tyrolean Cancer Research Institute, Innsbruck, Austria
    BMC Cancer 12:501. 2012
    The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients...
  52. pmc Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma
    Tada Kunavisarut
    Alex and Simona Shnaider Laboratory in Molecular Oncology, Department of Pathology and Laboratory Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Suite L6 304, Toronto, ON, M5T 3L9, Canada
    BMC Cancer 12:523. 2012
    ..The management of PTMC remains a controversy due to differing natural history of these patients. Epithelial cell adhesion molecule (EpCAM) is comprised of an extracellular domain (EpEx), a single transmembrane domain and an ..
  53. pmc EpCAM proteolysis: new fragments with distinct functions?
    Ulrike Schnell
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, P O Box 196, 9700 AD, Groningen, The Netherlands
    Biosci Rep 33:e00030. 2013
    EpCAM [epithelial cell adhesion molecule; CD326 (cluster of differentiation 326)] is highly expressed on epithelium-derived tumours and can play a role in cell proliferation...
  54. pmc EpCAM expression varies significantly and is differentially associated with prognosis in the luminal B HER2(+), basal-like, and HER2 intrinsic subtypes of breast cancer
    S D Soysal
    Department of Surgery, University Hospital Basel, Spitalstrasse 21, Basel 4031, Switzerland
    Br J Cancer 108:1480-7. 2013
    b>Epithelial cell adhesion molecule (EpCAM) is frequently expressed in breast cancer, and its expression has been associated with poor prognosis...
  55. doi EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells
    Salah Eldin Gadalla
    Department of Oncology Pathology, Karolinska Institutet, Cancer Center Karolinska, R8 04 Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden Electronic address
    Biochem Biophys Res Commun 439:203-8. 2013
    b>Epithelial cell adhesion molecule (EpCAM) is an epithelial and cancer cell "marker" and there is a cumulative and growing evidence of its signaling role...
  56. doi Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway
    Jie Ni
    Cancer Care Centre and Prostate Cancer Institute, St George Hospital, Kogarah, NSW 2217, Australia St George Clinical School, University of New South Wales UNSW, Kensington, NSW 2052, Australia
    Int J Biochem Cell Biol 45:2736-48. 2013
    Prostate cancer (CaP) is the second leading malignancy in men. The role of epithelial cell adhesion molecule (EpCAM), also known as CD326, in CaP progression and therapeutic resistance is still uncertain...
  57. pmc Expression of EpCAM(MF) and EpCAM(MT) variants in human carcinomas
    Dominic Fong
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    J Clin Pathol 67:408-14. 2014
    ..intramembrane proteolysis has been shown to be an important mechanism for oncogenic activation of epithelial cell adhesion molecule (EpCAM) through nuclear translocation of the intracellular domain EpICD...
  58. pmc Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells
    Suneetha Nunna
    Institute of Biochemistry, Stuttgart University, Stuttgart, Germany
    PLoS ONE 9:e87703. 2014
    The Epithelial Cell Adhesion Molecule (EpCAM) is overexpressed in many cancers including ovarian cancer and EpCAM overexpression correlates with decreased survival of patients...
  59. ncbi EpCAM expression in retinoblastoma: a novel molecular target for therapy
    Subramanian Krishnakumar
    Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, 18 College Road, Chennai 600006, Tamil Nadu, India
    Invest Ophthalmol Vis Sci 45:4247-50. 2004
    ..It was first determined whether EpCAM is expressed in retinoblastoma and then whether EpCAM reactivity correlates with tumor aggressiveness.
  60. pmc A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators
    K Maaser
    Molecular Medicine and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Br J Cancer 99:1635-43. 2008
    Expression of the epithelial cell adhesion molecule EpCAM is upregulated in a variety of carcinomas. This antigen is therefore explored in tumour diagnosis, and clinical trials have been initiated to examine EpCAM-based therapies...
  61. ncbi Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA
    J Strnad
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285
    Cancer Res 49:314-7. 1989
    A human adenocarcinoma-associated antigen (KSA) defined by the monoclonal antibody KS1/4 has become the focus of several site-directed strategies for tumor therapy...
  62. ncbi Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer
    Viola A Heinzelmann-Schwarz
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    Clin Cancer Res 10:4427-36. 2004
    ..The aims of this study were to integrate the results from 14 transcript profiling studies of EOC to identify novel biomarkers and to examine their expression in early and late stages of the disease...
  63. ncbi The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP
    Markus Munz
    Head and Neck Research Department, Clinical Cooperation Group Molecular Oncology, GSF, National Research Center for Environment and Health, Marchioninistr 15, 81377 Munich, Germany
    Cancer Lett 225:151-7. 2005
    The epithelial cell adhesion molecule, EpCAM, is a transmembrane glycoprotein associated with both benign and malignant proliferation...
  64. ncbi Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys
    Monika Trzpis
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen UMCG, Groningen, The Netherlands
    Nephron Exp Nephrol 107:e119-31. 2007
    The epithelial cell adhesion molecule (EpCAM) is expressed by most epithelia and is involved in processes fundamental for morphogenesis, including cell-cell adhesion, proliferation, differentiation, and migration...
  65. pmc Identification of EpCAM as the gene for congenital tufting enteropathy
    Mamata Sivagnanam
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego, La Jolla, California, USA
    Gastroenterology 135:429-37. 2008
    ..The pathogenesis and genetics of this disorder are not well understood. The objective of this study was to identify the gene responsible for CTE...
  66. ncbi CpG island methylation status in the EpCAM promoter region and gene expression
    Guolong Yu
    Department of Anatomy and Brain Research, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, P R China
    Oncol Rep 20:1061-7. 2008
    The epithelial cell adhesion molecule (EpCAM) gene has been found to be highly expressed in carcinomas of various origins; however, the molecular mechanisms underlying the transcriptional regulation of EpCAM remain poorly understood...
  67. doi EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma
    Benoit Terris
    Institut Cochin, Département Endocrinologie Métabolisme et Cancer, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Hepatol 52:280-1. 2010
    ..We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer cells with stem/progenitor features...
  68. pmc Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases
    Ashley Cimino
    Department of Pathology, Johns Hopkins Hospital, Weinberg 2242, 401 North Broadway, Baltimore, MD 21231, USA
    Breast Cancer Res Treat 123:701-8. 2010
    b>EpCAM (CD326) has diverse roles in cell adhesion and proliferation, and is known to be overexpressed in primary breast carcinomas (PBCs)...
  69. doi EpCAM expression is an indicator of recurrence in basal-like breast cancer
    Ayodeji J Agboola
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Breast Cancer Res Treat 133:575-82. 2012
    ..This study investigates the expression of epithelial cell adhesion molecule (EpCAM) in breast cancer particularly basal-like phenotype group which remains unclear...
  70. doi Prognostic significance of EpCAM-positive disseminated tumor cells in rectal cancer patients with stage I disease
    Sameer Dhayat
    Department of General, Visceral, and Paediatric Surgery, University Hospital Dusseldorf, 40225 Dusseldorf, Germany
    Am J Surg Pathol 36:1809-16. 2012
    Here we evaluated the prevalence and prognostic impact of epithelial cell adhesion molecule (EpCAM)-positive disseminated tumor cells (DTCs) in stage I rectal cancer...
  71. pmc Retroposition in a family of carcinoma-associated antigen genes
    A J Linnenbach
    Wistar Institute, Philadelphia, Pennsylvania 19104
    Mol Cell Biol 13:1507-15. 1993
    ..Analysis of GA733-2 exons revealed that many delineate structural motifs. The GA733-1 retroposon was localized either to chromosome region 1p32-1p31 or to 1p13-1q12, and the GA733-2 founder gene was localized to chromosome 4q...
  72. doi Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation
    Bernardina T F van der Gun
    Department of Pathology and Laboratory Medicine, Section Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Int J Cancer 123:484-9. 2008
    The epithelial cell adhesion molecule (EpCAM) is expressed at high levels on the surface of most carcinoma cells...
  73. ncbi The emergence of Taenia solium cysticercosis in Eastern and Southern Africa as a serious agricultural problem and public health risk
    Isaac K Phiri
    School of Veterinary Medicine, University of Zambia, PO Box 32379 Lusaka, Zambia
    Acta Trop 87:13-23. 2003
    Pig production has increased significantly in the Eastern and Southern Africa (ESA) region during the past decade, especially in rural, resource-poor, smallholder communities...
  74. ncbi High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer model
    T M Behr
    Department of Nuclear Medicine, Georg August University, Gottingen, Germany
    Cancer Res 59:2635-43. 1999
    ..Due to its short physical half-life, 213Bi appears to be especially suitable for use in conjunction with fast-clearing fragments...
  75. ncbi Survey of attitudes of physicians toward the current evaluation and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)
    Muhammad Ziad Souqiyyeh
    Saudi Center for Organ Transplantation, P O Box 27049, Riyadh 11417, Saudi Arabia
    Saudi J Kidney Dis Transpl 21:93-101. 2010
    ..in this study to determine the opinion of the medical directors of dialysis centers in the Kingdom of Saudi Arabia (KSA) about the updates of strategies for evaluation and treatment of chronic kidney disease-mineral and bone Disorder (..
  76. ncbi Determination of nitrofurantoin, furazolidone and furaltadone in milk by high-performance liquid chromatography with electrochemical detection
    T Galeano Díaz
    Department of Analytical Chemistry, Faculty of Sciences, University of Extremadura, Badajoz, Spain
    J Chromatogr A 764:243-8. 1997
    ..A Nova-Pak C18 column (150 x 3.9 mm) and a Coulochem II detector from ESA have been used...
  77. ncbi Smokeless tobacco (shamma) and oral cancer in Saudi Arabia
    W F Allard
    Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    Community Dent Oral Epidemiol 27:398-405. 1999
    ..Shamma is a preparation of smokeless tobacco. Previous investigators in the Kingdom of Saudi Arabia (KSA) have reported a relationship between their patients with oral cancer and a history of using shamma...
  78. ncbi The knowledge and practices of oral hygiene methods and attendance pattern among school teachers in Riyadh, Saudi Arabia
    Khalid Almas
    Department of Preventive Dental Sciences, King Aaud University, College of Dentistry, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 24:1087-91. 2003
    The aim of this study was to find out the knowledge and practices of oral hygiene methods among primary and secondary school teachers in Riyadh, Kingdom of Saudi Arabia (KSA).
  79. ncbi Pyramidal-cell plasticity in weakly electric fish: a mechanism for attenuating responses to reafferent electrosensory inputs
    J Bastian
    Department of Zoology, University of Oklahoma, Norman 73019
    J Comp Physiol A 176:63-73. 1995
    ..Both proprioceptive input and descending electrosensory input to the posterior eminentia granularis are involved in generating the observed plastic changes in pyramidal cell responsiveness...
  80. doi Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats
    Lars P Klieverik
    Academic Medical Center, Univ of Amsterdam, Dept of Endocrinology and Metabolism, F5 162, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Endocrinol Metab 294:E513-20. 2008
    ..Sympathetic hepatic innervation contributes only to a limited extent to increased EGP during thyrotoxicosis, whereas parasympathetic hepatic innervation may function to restrain EGP in this condition...
  81. ncbi Erector spinae lever arm length variations with changes in spinal curvature
    P Tveit
    Department of Physiology III, Karolinska Institute, Stockholm, Sweden
    Spine (Phila Pa 1976) 19:199-204. 1994
    ..Images were analyzed for lever arm lengths of the erector spinae muscle (ES) and the erector spinae aponeurosis (ESA), the latter functioning as a tendon for superiorly positioned ES muscle portions...
  82. ncbi Survey of attitude of physicians on updates in the management of anemia in chronic kidney disease patients
    Muhammad Ziad Souqiyyeh
    Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia
    Saudi J Kidney Dis Transpl 20:410-6. 2009
    ..We aimed in this study to assess the opinion of medical directors of dialysis centers in the Kingdom of Saudi Arabia (KSA) about updates of strategies for treatment of anemia in patients with chronic kidney disease (CKD)...
  83. ncbi Use of erythropoiesis-stimulating agents among chemotherapy patients with hemoglobin exceeding 12 grams per deciliter
    Beth L Nordstrom
    United BioSource Corporation, 430 Bedford Street, Suite 300, Lexington, MA 02420, USA
    J Manag Care Pharm 14:858-69. 2008
    ..was added to the labels of the ESAs in March 2008, and the FDA mandated further label changes on July 30, 2008, that ESA therapy should not be initiated in patients receiving chemotherapy at Hb levels of 10 gm per dL or higher.
  84. pmc A potential role for muscle in glucose homeostasis: in vivo kinetic studies in glycogen storage disease type 1a and fructose-1,6-bisphosphatase deficiency
    Hidde H Huidekoper
    Department of Pediatrics Academic Medical Center, University Hospital of Amsterdam, The Netherlands
    J Inherit Metab Dis 33:25-31. 2010
    ..To study the role of extrahepatic tissue in glucose homeostasis during fasting glucose kinetics were studied in two patients with a deficient hepatic and renal glycogenolysis and/or gluconeogenesis...
  85. ncbi Prediction of three-dimensional structure and mapping of conformational epitopes of envelope glycoprotein of Japanese encephalitis virus
    A S Kolaskar
    Bioinformatics Centre, University of Pune, Pune, 411 007, India
    Virology 261:31-42. 1999
    ..This is one of the largest proteins whose three-dimensional structure has been predicted using an homology modeling approach and water as a solvent...
  86. ncbi [Comparison of echocardiographic automatic border detection and magnetic resonance imaging. Measurements of the left ventricle in normal subjects]
    S Lafitte
    , , Pessac
    Arch Mal Coeur Vaiss 91:389-95. 1998
    ..Twenty healthy subjects underwent measurement of end systolic surface (ESA) and end diastolic surface areas (EDA) and fraction of surface variation (FSV), end systolic volume (ESV), end ..
  87. ncbi Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait, 13110
    Life Sci 77:2552-73. 2005
    ....
  88. pmc Every-other-week darbepoetin alfa in the correction and maintenance of haemoglobin levels in elderly patients with chronic kidney disease: post hoc subanalysis of data from two clinical trials
    Michelle W Krause
    University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Drugs Aging 26:665-75. 2009
    ..Although extended dosing with darbepoetin alfa, an erythropoiesis-stimulating agent (ESA), has been shown to be effective in maintaining haemoglobin (Hb) levels in CKD patients, little information is ..
  89. doi Molt cycle regulation of protein synthesis in skeletal muscle of the blackback land crab, Gecarcinus lateralis, and the differential expression of a myostatin-like factor during atrophy induced by molting or unweighting
    J A Covi
    Department of Biology, Colorado State University, Fort Collins, CO 80523 USA
    J Exp Biol 213:172-83. 2010
    ..in both the claw closer and weighted thoracic muscles when molting was induced by either eyestalk ablation (ESA) or multiple limb autotomy (MLA). However, the effect of molt induction was greater in the claw muscle...
  90. ncbi The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats
    Fatima R S Freitas
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Bone Miner Res 20:294-304. 2005
    ..Our findings indicate that T3 exerts some essential effects on bone development that are mediated by TRbeta1...
  91. ncbi Multinodular goiter management in Western Saudi Arabia
    Faiza A Qari
    Medical Department, King Abdul Aziz University Hospital, PO Box 13042, Jeddah 21943, Kingdom of Saudi Arabia
    Saudi Med J 26:438-41. 2005
    The aim of this study was to provide epidemiological data and summarize the different modalities of management of multinodular goiters (MNG) in the Western Province of Saudi Arabia (KSA).
  92. ncbi Effect of erythropoiesis-stimulating agents on healthcare utilization, costs, and outcomes in chronic kidney disease
    Franklin W Maddux
    Specialty Care Services Group, Nashville, TN 37203, USA
    Ann Pharmacother 41:1761-9. 2007
    ..Anemia commonly complicates chronic kidney disease (CKD). Treating anemia of CKD with erythropoiesis-stimulating agents (ESAs) may attenuate cardiovascular and renal sequelae, reducing morbidity, mortality, and healthcare costs...
  93. doi ESSC-ESF position paper--science-driven scenario for space exploration: report from the European Space Sciences Committee (ESSC)
    Jean Claude Worms
    ESSC ESF, Strasbourg, France
    Astrobiology 9:23-41. 2009
    In 2005 the then ESA Directorate for Human Spaceflight, Microgravity and Exploration (D-HME) commissioned a study from the European Science Foundation's (ESF) European Space Sciences Committee (ESSC) to examine the science aspects of the ..
  94. doi A US multicenter, retrospective, observational study of erythropoiesis-stimulating agent utilization in anemic, critically ill patients admitted to the intensive care unit
    Gretchen M Brophy
    Departments of Pharmacy and Neurosurgery, Virginia Commonwealth University, Richmond, Virginia 23298 0533, USA
    Clin Ther 30:2324-34. 2008
    ..Darbepoietin alfa and epoetin alfa are erythropoiesis-stimulating agents (ESAs) used to manage anemia in the ICU, although neither drug has an indication in critically ill patients...
  95. pmc Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition
    Kazunari Kondo
    Division of Novel Food and Immunochemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
    J Biol Chem 285:13079-91. 2010
    ..PARP-1-independent AIF release and cell death are induced by a trienoic fatty acid, alpha-eleostearic acid (alpha-ESA)...
  96. ncbi Reflections of ions in electrostatic analyzers: a case study with New Horizons/Solar Wind Around Pluto
    B M Randol
    Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, Texas 78229, USA
    Rev Sci Instrum 81:114501. 2010
    ..In this article, we describe how ions reflect from the interior surfaces of an ESA, the detection of which constitutes a fundamentally nonideal response of ESAs...
  97. ncbi Prevalence of anti-hepatitis B and anti-hepatitis A antibodies among school aged children in Western Saudi Arabia
    Soad M Jaber
    Department of Pediatrics, King Abdul Aziz University Hospital, PO Box 80205, Jeddah 21589, Kingdom of Saudi Arabia
    Saudi Med J 27:1515-22. 2006
    To determine the seroprevalence of antibodies to hepatitis B virus (HBV) and hepatitis A virus (HAV) among children in Jeddah, Kingdom of Saudi Arabia (KSA) and to evaluate the need of anti-HAV mass vaccination.
  98. ncbi The structural analysis of adhesions mediated by Ep-CAM
    M Balzar
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    Exp Cell Res 246:108-21. 1999
    The epithelial cell adhesion molecule Ep-CAM is capable of mediating Ca2+-independent homotypic cell-cell adhesion when introduced into cells lacking their own means of cell-cell interactions...
  99. ncbi Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid
    Tsuyoshi Tsuzuki
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Nutr 136:2153-9. 2006
    We showed previously that alpha-eleostearic acid (alpha-ESA; 9Z11E13E-18:3) is converted to 9Z11E-conjugated linoleic acid (CLA) in rats through a Delta13-saturation reaction...
  100. doi Adherence to guidelines for use of erythropoiesis-stimulating agents in patients with chemotherapy-induced anemia: results of a retrospective study of an electronic medical-records database in the United States, 2002-2006
    Weixiu Luo
    United BioSource Corporation, 430 Bedford Street, Suite 300, Lexington Office Park, Lexington, MA 02420, USA
    Clin Ther 30:2423-35. 2008
    ..Because of poorer disease outcomes and increased risk of adverse events associated with ESAs in recent studies, the use of ESAs has been increasingly restricted in practice guidelines in the years 2007 and 2008...
  101. doi Erythropoiesis stimulating agent administration improves survival after severe traumatic brain injury: a matched case control study
    Peep Talving
    University of Southern California Keck School of Medicine, Department of Surgery Division of Acute Care Surgery Emergency Surgery, Trauma, and Surgical Critical Care, Los Angeles County General Hospital LAC USC, 1200 North State St, C4E100, Los Angeles, CA 90033, USA
    Ann Surg 251:1-4. 2010
    Erythropoiesis stimulating agent (ESA) administration may reduce mortality in severe traumatic brain injury (sTBI).

Research Grants69

  1. David Kuhrt; Fiscal Year: 2015
    ..In Trib3-KO mice, I have found that steady state erythropoiesis is unperturbed, but during anemia or ESA administration stress erythropoiesis in bone marrow is compromised...
  2. Anna Rita F Migliaccio; Fiscal Year: 2015
    ..DXM is used as erythropoiesis stimulating agent (ESA) to rescue the deficient terminal erythroid (EB) maturation observed in patients with Diamond Blackfan Anemia (DBA),..
  3. Adam E Gaweda; Fiscal Year: 2015
    ..Evidence shows that excessive doses of Erythropoiesis Stimulating Agents (ESA), used in hypo-responsive patients, coincide with increased cardiovascular complications...
  4. MEREDITH ANN ATKINSON; Fiscal Year: 2015
    ..Anemia which does not respond to treatment with erythropoiesis stimulating agents (ESA) is common in clinical practice...
  5. Do Safety Warnings Change Prescribing among the US Dialysis Population?
    Mae Thamer; Fiscal Year: 2012
    ..a Black Box Warning that went out to all practicing nephrologists) indicating the safety risks associated with ESA therapy and recommendations to use 'the lowest dose possible to avoid blood transfusions'resulted in a ..
  6. Comparative Effectiveness and Safety of Newer Agents for Anemia Treatment in HD
    WOLFGANG CHRISTOPH WINKELMAYER; Fiscal Year: 2013
    ..based on patient characteristics, we can exploit natural experiments that occur when facilities switch their ESA or iron agent for their entire patient population...
  7. Yossi Chait; Fiscal Year: 2016
    ..Increased use of ESA's has also led to recognition of their limitations by virtue of observed adverse events...
  8. Erythropoiesis-stimulating agent use among chronic kidney disease patients
    DENNIS JOSEPH COTTER; Fiscal Year: 2012
    ..Erythropoiesis-stimulating agents (ESA therapy) - approved in 1989 for use among the renal disease population - is used to correct anemia...
  9. DENNIS JOSEPH COTTER; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): ESA Outcomes Among Anemic CKD Patients Background. There has been a 30% increase in chronic kidney disease (CKD) over the past decade...
  10. Robin K Ohls; Fiscal Year: 2014
    ..intervention is the use of recombinant erythropoietin (Epo, also known as an erythropoiesis stimulating agent, or ESA)...
  11. Harvey Jay Cohen; Fiscal Year: 2016
    ..Our initial protocol will consist of a randomized treatment trial of (ESA) or placebo among UAE patients 70 years and older...
  12. Comparative Effectiveness: Erythropoietic Stimulating Agents in Treatment of MDS
    Amy J Davidoff; Fiscal Year: 2010
    ..This study will examine patterns of treatment with erythropoietic stimulating agents (ESA) in patients with myelodysplastic syndromes (MDS), and compare clinical benefits, risks, and costs associated with ..
  13. ESTABLISHMENT OF RESEARCH RESOURCEFOR THE IDENTIFICATION OF GENETIC AND ENVIRONM
    VAINORIOUS E; Fiscal Year: 2009
    ....
  14. Lishan Su; Fiscal Year: 2016
    ..AFC8- hu mice engrafted with CD34+ human hematopoietic stem cells and EpCAM+ human hepatoblasts and hepatic stem cells achieve ~18% hepatic chimerism, are permissive for HCV infection, and ..
  15. Atypical Antipsychotics: Effects on Hepatic Glucose and Lipid Metabolism in Human
    Michael R Rickels; Fiscal Year: 2012
    ..Findings from these studies will have important clinical relevance to the treatment of schizophrenia. ..
  16. Sweet taste receptors and glucose metabolism in healthy and T2DM humans
    Karen L Teff; Fiscal Year: 2012
    ..Our overall hypothesis is that in healthy subjects, the STR receptor is involved in the regulation of post-prandial glucose metabolism and GLP levels but in T2DM, the STR receptor is unresponsive to activation or inhibition ..
  17. Prevalence of CD24 epigenetic silencing in breast tumors and ERalpha status
    Benny Abraham Kaipparettu; Fiscal Year: 2012
    ..Interestingly, epithelial cells with the CD44 positive CD24 low/absent marker combination (ESA????/low) are considered putative BCSCs...
  18. Testing of novel anti-cancer compounds Curaxins against pancreatic cancer
    Katerina Gurova; Fiscal Year: 2013
    ..into pancreatic cancer stem cells (PCSC) and bulk PDA cells based on expression of PCSC markers (CD24, CD44 and ESA). The CX concentration killing the majority of cells (LC90) will be determined for each cell sample...
  19. Intestinal Epithelial Function in Congenital Tufting Enteropathy
    MAMATA B SIVAGNANAM; Fiscal Year: 2013
    ..a systematic genetic mapping approach, we were able to identify mutations in the gene that codes for Epithelial Cell Adhesion Molecule (EpCAM)...
  20. Characterization of Endoderm Stem Cells Derived from Murine ESCs
    Jon S Odorico; Fiscal Year: 2010
    ..endoderm-committed cells from heterogeneous cultures of differentiated murine ESCs on the basis of epithelial cell adhesion molecule (EpCAM) expression...
  21. KIMBERLEY JANE EVASON; Fiscal Year: 2016
    ..activated [unreadable]-catenin promotes tumor formation in fish via activation of specific genes, including myc, epcam, lef1, foxo1a, and iqgap2, and regulation of specific microRNAs. Dr...
  22. Meredith A Hawkins; Fiscal Year: 2016
    ..Since our preliminary data suggest that CNS inputs play a key role in the regulation of hepatic glucose fluxes in humans, restoring this regulation could be an important target for intervention in individuals with T2DM. ..
  23. Sapna Syngal; Fiscal Year: 2016
    ..Since the development of the model, two additional genes, PMS2 and EPCAM, have been implicated in the condition...
  24. Humanized Anti-Trop2-SN-38 Conjugate For Advanced Pancreatic Cancer
    William A Wegener; Fiscal Year: 2012
    ....
  25. Charlotte Kuperwasser; Fiscal Year: 2016
    ..two luminal phenotypes and two basal phenotypes) within human breast tissues that differ on the basis of CD24, EpCAM and CD49f expression, ii) the existence of bipotent progenitors that contribute to structurally distinct elements (..
  26. Advanced Development of An Integrated CTC Enrichment Technology
    Hsian Rong Tseng; Fiscal Year: 2013
    ..Initially, we pioneered the concept of applying anti-EpCAM (epithelial cell adhesion molecule)-coated nanostructured surfaces as a high-affinity substrate for enrichment of CTCs...
  27. Nanoporous Drug Delivery Systems
    Sergei N Smirnov; Fiscal Year: 2013
    ..in vitro delivery of two small drug molecules, doxorubicin and paclitaxel and short strand 'therapeutic nucleic acids'(TNA) into cancerous cell lines that are targeted by one of three ligands, folic acid, EpCAM and HER2.
  28. Peripheral blood biopsy for molecular diagnosis of pancreatic cancer
    Sunil R Hingorani; Fiscal Year: 2013
    ..The current FDA-approved CTC enrichment technique collects cells expressing only relatively high levels of EpCam which is known to be highly variable and low in some tumor types...
  29. REGULATION OF HEPATIC GLUCOSE FLUXES
    Meredith A Hawkins; Fiscal Year: 2012
    ..Since our preliminary data suggest that central inputs play a key role in the regulation of hepatic glucose fluxes in humans, restoring this regulation could be an important target for intervention in individuals with T2DM. ..
  30. Yu Tsueng Liu; Fiscal Year: 2015
    ..Lipid shell-perfluorocarbon buoyant microbubbles (MBs) coated with anti-EpCAM antibody immediately attached to tumor cells in unfractionated blood, and isolated the cells after a quick ..
  31. Alexei A Bogdanov; Fiscal Year: 2016
    ..the MRamp technique to meet the challenges of MR molecular imaging of epidermal growth factor (EGF) receptor and EpCAM cell-surface molecule as potential markers for targeted imaging of metastasis...
  32. 3D-Nanostrcutured Substrates for Detection of Circulating Tumor Cells
    Hsian Rong Tseng; Fiscal Year: 2011
    ..The PI's research group has demonstrated that a silicon nanopillar (SiNP)-covered substrate, coated with anti-EpCAM, exhibits outstanding efficiency when employed to isolate viable CTCs from whole blood samples...
  33. Sharmila Shankar; Fiscal Year: 2016
    ..We have recently demonstrated that human CD133+CD44+CD24+ESA+ CSCs express Nanog, Notch-1 and Oct-4 and are highly tumorigenic in mice...
  34. Nanotube Antibody Arrays for Profiling Circulating Diseased Cells
    Balaji Panchapakesan; Fiscal Year: 2011
    ..Detection of molecular surface receptors namely IGF1R, Her2, and EpCAM in BT474, MCF7, SKBR3 and MCF10A cancer cells in blood...
  35. Marcia M Ward; Fiscal Year: 2014
    ..safety culture, teamwork attitudes and performance, initiative fidelity, and observed knowledge-skills- attitude (KSA) behaviors) and outcomes over time;and 4) Identify the TeamSTEPPS strategies that are most successful in terms of ..
  36. Behavioral Brand Builder - A brand development training program with an integrate
    TONY XUYEN MA; Fiscal Year: 2012
    ..The long-term product goal is to develop the B3 to be user-friendly, cross-domain to help to: 1) increased KSA for researchers in the field of behavioral health interventions, 2) increased return on investment for ..
  37. DETECTION OF BIOMOLECULES BY CHEMILUMINESCENCE
    NEIL DANIELSON; Fiscal Year: 1990
    ..start-up and more versatile operation, we plan to do on- line oxidation of Ru(bpy)3+2 to Ru(byp)3+3 using the ESA coulometric flow cell...
  38. ESA, a Novel Anti-inflammation Agent
    PETER RECZEK; Fiscal Year: 2009
    ..We have recently discovered that Esculentoside A (EsA), a saponin isolated from Phytolacca esculenta, has multifactorial anti-inflammatory activity and specifically ..
  39. Developing predictive biomarkers in metastatic breast cancer using LiquidBiopsy
    Paul Dempsey; Fiscal Year: 2013
    ..The platform will be evaluated with metastatic breast cancer patients by determining whether the legacy marker Epcam or an expanded cocktail recover more mutation bearing CTC...
  40. MAb-based targeted chemotherapy of lung cancer
    Serengulam Govindan; Fiscal Year: 2009
    ..The ultimate goal of the proposed project is to develop a safer and more efficacious targeted chemotherapy of non-small cell lung cancer using a tumor-selective monoclonal antibody and the highly potent form of the cancer drug, CPT-11. ..
  41. Elastic Shape Analysis for Protein Structure Alignment-New Advancement in an Old
    Jinfeng Zhang; Fiscal Year: 2013
    ..In this proposal, we develop methods based on elastic shape analysis (ESA) for protein structure comparison and alignment...
  42. Modulation of Hypoglycemic Counterregulatory Responses
    Harry Shamoon; Fiscal Year: 2006
    ..abstract_text> ..
  43. MAb-based targeted chemotherapy of lung cancer
    Serengulam Govindan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. RADIOLABELED MONOCLONAL ANTIBODIES FOR CANCER THERAPY
    LEE WASHBURN; Fiscal Year: 1990
    ..This multidiscplinary research approach, which combines the fields of bio-organic chemistry, immunochemistry, and radiopharmacology, is aimed at development of improved methods for radioimmunotherapy of cancer in man...
  45. ANALYSIS OF NON-SMALL CELL LUNG CARCINOMA ANTIGENS
    PER PETERSON; Fiscal Year: 1990
    ....
  46. Enhanced endothelialization for tissue engineering
    Kytai Nguyen; Fiscal Year: 2006
    ..onto PLLA surfaces using different immobilized techniques: coating, cross-linking, and electrostatic self-assembly (ESA)...
  47. NMR STUDIES:HEPATIC GLUCOSE METABOL IN HUMANS EXERCISING
    Kitt Petersen; Fiscal Year: 2003
    ..The results of these studies should provide important new insight into the regulation of hepatic glucose metabolism in healthy and type 1 diabetic subjects. ..
  48. PHASE I CLINICAL TRIAL WITH MONOCLONAL ANTI-IDIOTYPE
    Dorothee Herlyn; Fiscal Year: 1991
    ..Possible effects of Ab2 immunizations on growth of CRC will be related to the patients' immunological responses...
  49. Point of Care Device for Antibody Independent Isolation of Circulating Tumor
    Darren Davis; Fiscal Year: 2013
    Detection of circulating tumor cells (CTCs) using immunomagnetic EpCAM-based methods have been conceptually accepted as a ―liquid tumor biopsy‖...
  50. A GLUCOSE OXIDASE-BASED IMMUNOTOXIN PRODUCED IN YEAST
    Robert Blackburn; Fiscal Year: 2000
    ..abstract_text> ..
  51. METABOLISM OF THE EGP-RECEPTOR AND ERB B PROTEIN
    STUART DECKER; Fiscal Year: 1992
    ..Analysis of a M=100,000 Drosophila growth factor binding protein will continue. Structural comparison of the v-erbA and c-erbA proteins will be performed, again, using antiserum prepared against recombinant protein...
  52. CO17 1A/GA733 ANTIGEN IN COLORECTAL CANCER THERAPY
    Dorothee Herlyn; Fiscal Year: 2002
    ..It is expected that this program will contribute to improvement and better understanding of active immunotherapy against CRC. ..
  53. DNA repair deficient human cells for genomic variation analysis
    JAY GEORGE; Fiscal Year: 2009
    ..In the proposal we plan to develop real time in vivo assays to monitor glycosylase activity. Additionally we intend to determine the effect of depletion of a single glycosylases on the global transcriptome. ..
  54. EXERCISE AND FUEL METABOLISM
    David Wasserman; Fiscal Year: 2007
    ..abstract_text> ..
  55. LEARNING THROUGH ENVIRONMENTAL HEALTH SCIENCE SCENARIOS
    Nancy Kerkvliet; Fiscal Year: 2006
    ..Challenge Problems, an existing set of environmental health science scenarios, developed under NIEHS grant ESA-96-001, to improve the critical-thinking skills of high school students and to engage them in developing solutions ..
  56. Isolation of Circulating Tumor Cells from Peripheral Blood
    STEVEN BOGEN; Fiscal Year: 2007
    ..We have overcome the problem of limited EpCAM expression on CTCs associated with positive selection cell separation methods by designing ours as a negative ..
  57. Enzymatic deglycation of nonenzymatic glycation products
    Benjamin Szwergold; Fiscal Year: 2006
    ..This grant will enable us to further study the transglycation reaction pathway and to determine its importance in normoglycemic and diabetic individuals. ..
  58. BIOMEDICAL RESEARCH AT THE UNIVERSITY OF GUAM
    Peter J Schupp; Fiscal Year: 2010
    ..Upon reestablishment of the SCORE program, the PIs and proposed External Scientific Advisor (ESA) will mentor other faculty in establishing their own research programs...
  59. METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE
    Wayne Matson; Fiscal Year: 1990
    ..multiparameter measurements and the procedures for rapid data reduction, transfer and management developed for the ESA Neurochemical Analyzer (NCA)...
  60. Breaking tolerance to mEGP self-antigen
    Dorothee Herlyn; Fiscal Year: 2009
    ..The human gastrointestinal carcinoma-associatedAg GA733 (EpCAM) has been a suitable target for passive and active immunotherapy of these tumors in cancer patients...
  61. ESA, a Novel Anti-inflammation Agent
    Lurong Zhang; Fiscal Year: 2005
    We have discovered that Esculentoside A (EsA) has potent anti-inflammatory effects including specific COX2 inhibition...
  62. CHILD AND FAMILY THERAPY FOR ANXIETY-DISORDERED YOUTH
    PHILIP KENDALL; Fiscal Year: 2004
    ..ICBT), 50 cases to Family Cognitive-Behavioral Therapy (FCBT), and 50 cases to an education/support/attention (ESA) control condition. All conditions will be 16 sessions...
  63. Microsampling Unit for Capturing Low Abundant Cells
    Steven Soper; Fiscal Year: 2006
    ..beds prepared using surface imprinted polymers to semi-selectively capture pre-selected targets (cells expressing EpCAM). (2) Cellular lysis system...
  64. Microsampling Unit for Capturing Low Abundant Cells
    Steven Soper; Fiscal Year: 2003
    ..beds prepared using surface imprinted polymers to semi-selectively capture pre-selected targets (cells expressing EpCAM). (2) Cellular lysis system...

Patents1

  1. Methods vectors plasmids and methods for increasing expression ofrecombinant polypeptides
    Patent Number: WO2004033693-A1; Date:2004-04-22