Genomes and Genes
Gene Symbol: eotaxin
Description: C-C motif chemokine ligand 11
Alias: SCYA11, eotaxin, chemokine (C-C motif) ligand 11, eosinophil chemotactic protein, eotaxin-1, small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
Publications311 found, 100 shown here
- Human eotaxin represents a potent activator of the respiratory burst of human eosinophilsJ Elsner
Hannover Medical School, Department of Dermatology, Germany
Eur J Immunol 26:1919-25. 1996..Here, the effect of the recently cloned CC chemokine human eotaxin was investigated for its ability to affect different eosinophil effector functions and compared to the CC ..
- Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradationYi Hsin Hsu
Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
J Cell Biochem 93:929-39. 2004The expression of the chemokine, eotaxin-1, and its receptors in normal and osteoarthritic human chondrocytes was examined, and its role in cartilage degradation was elucidated in this study...
- Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8Katerina Ajami
Centenary Institute, Faculty of Medicine, University of Sydney, Newtown, Sydney, NSW, Australia
FEBS Lett 582:819-25. 2008..This has implications for DP8 substrate specificity. Chemokine cleavage and inactivation may occur in vivo upon cell lysis and release of DP8 or in the inactivation of internalized chemokine/receptor complexes...
- Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophilsP D Ponath
LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
J Clin Invest 97:604-12. 1996The CC chemokine eotaxin, identified in guinea pigs and also recently in mice, may be a key element for the selective recruitment of eosinophils to certain inflamed tissues...
- Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3M Kitaura
Shionogi Institute for Medical Science, Osaka, Japan
J Biol Chem 271:7725-30. 1996The CC chemokine eotaxin is a selective chemoattractant for guinea pig eosinophils, first purified from bronchoalveolar lavage fluid in a guinea pig model of allergic airway inflammation...
- TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblastsSally E Wenzel
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Immunol 169:4613-9. 2002..These fibroblasts were exposed to TGF-beta1 and IL-13 alone or in combination, and eotaxin-1 expression and production were evaluated...
- A single nucleotide polymorphism on the promoter of eotaxin1 associates with its mRNA expression and asthma phenotypesHun Soo Chang
Division of Molecular and Life Sciences, Hanyang University, Ansan, Gyeonggi Do, Korea
J Immunol 174:1525-31. 2005..Our data suggest that the EOT-384A>G SNP participates in the regulation of eotaxin1 expression by providing a potential binding site for a repressor, and that the ANOVA of EOT-384A>G may predict asthma phenotypes...
- Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscleUte Oltmanns
Experimental Studies National Heart and Lung Institute, Imperial College, London SW36LY, UK
Respir Res 6:74. 2005..Human airway smooth muscle cells (HASMC) are a source of proinflammatory cytokines and chemokines. We investigated whether cigarette smoke could directly induce the release of chemokines from HASMC...
- Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophiliaE A Garcia-Zepeda
Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Nat Med 2:449-56. 1996b>Eotaxin is an eosinophil-specific chemoattractant that has been recently identified in rodent models of asthma and host response against tumors...
- Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophilsP D Ponath
LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
J Exp Med 183:2437-48. 1996The chemokine eotaxin is unusual in that it appears to be a highly specific chemoattractant for eosinophils...
- Genomic organization, sequence, and transcriptional regulation of the human eotaxin geneH Hein
Department of Dermatology, University of Kiel, Germany
Biochem Biophys Res Commun 237:537-42. 1997b>Eotaxin is an eosinophil specific beta-chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. Its expression is stimulus- and cell-specific...
- Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5P Ogilvie
Institute for Research in Biomedicine, Bellinzona, Switzerland
Blood 97:1920-4. 2001b>Eotaxin is a potent inducer of eosinophil chemotaxis and was considered as a selective ligand of the CC chemokine receptor 3 (CCR3), which is expressed on eosinophils, basophils, and Th2 lymphocytes...
- Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitisV Bocchino
Department of Respiratory Disease, University of Parma, Italy
Allergy 57:17-22. 2002..b>Eotaxin is the most potent and selective eosinophil chemoattractant which can also attracts lymphocytes...
- MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmissionWilliam S Modi
SAIC Frederick and the Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
AIDS 17:2357-65. 2003MCP-1 (CCL2), MCP-3 (CCL7), and eotaxin (CCL11) are genes for CC chemokines clustered on the long arm of chromosome 17...
- Chemokines in the limbal form of vernal keratoconjunctivitisA M Abu El-Asrar
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Br J Ophthalmol 84:1360-6. 2000..The aims of this study were to investigate the expression of the CC chemokines, RANTES, eotaxin, monocyte chemotactic protein (MCP) 1, MCP-2, and MCP-3 in the conjunctiva of patients with vernal ..
- Human eosinophil adhesion and degranulation stimulated with eotaxin and RANTES in vitro: lack of interaction with nitric oxideLeticia Lintomen
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas Sao Paulo, Brazil
BMC Pulm Med 8:13. 2008..out functional assays (adhesion and degranulation) and flow cytometry analysis of adhesion molecules (VLA-4 and Mac-1 expression) to evaluate the interactions between NO and CC-chemokines (eotaxin and RANTES) in human eosinophils.
- Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmaticsS Ying
Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
J Immunol 163:6321-9. 1999..We examined the expression of eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), MCP-4, and CCR3 in the bronchial mucosa from ..
- Eotaxin-3/CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6Carine Blanchard
INSERM U45, Faculte de Medecine Laennec, 69372 Lyon Cedex 08, France
Int J Biochem Cell Biol 37:2559-73. 2005..The mechanisms that govern mucosal infiltration with eosinophils are not fully understood. Eotaxin-3/CCL-26 belongs to a family of CC chemokines, which are potent chemoattractants for eosinophils...
- Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in vivoI Sabroe
Biomedical Sciences Division, Imperial College School of Medicine, London, United Kingdom
J Immunol 161:6139-47. 1998Certain C-C chemokines, signaling via the eotaxin receptor C-C chemokine receptor-3 (CCR3), are thought to be central mediators of eosinophil accumulation in allergic inflammation...
- Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophilsJ Elsner
Hannover Medical University, Department of Dermatology and Allergology, Germany
Eur J Immunol 28:2152-8. 1998..Recently, eotaxin was found to have the broadest spectrum of activities of all eosinophil-activating CC chemokines...
- Eotaxin stimulates eosinophil adhesion to human lung microvascular endothelial cellsA Burke-Gaffney
National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, United Kingdom
Biochem Biophys Res Commun 227:35-40. 1996Effects of the human C-C chemokines eotaxin, MIP-1 alpha, and RANTES on human eosinophil or neutrophil adhesion to human lung microvascular endothelial cells (LMVEC) were investigated...
- The CC chemokine antagonist Met-RANTES inhibits eosinophil effector functions through the chemokine receptors CCR1 and CCR3J Elsner
Hannover Medical School, Department of Dermatology, Germany
Eur J Immunol 27:2892-8. 1997..on human eosinophil effector functions in response to RANTES, monocyte chemoattractant protein (MCP)-3 and eotaxin. Met-RANTES was able to inhibit dose-dependently [Ca2+]i transients in eosinophils following stimulation with ..
- Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitisS Kagami
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Clin Exp Immunol 134:309-13. 2003..Recently, eotaxin-2/CCL24 and eotaxin-3/CCL26 were identified as CC chemokines that signal exclusively via the CCR3 receptor and ..
- The role of chemokines in Henoch Schonlein PurpuraFulya Tahan
Department of Pediatric Allergy, Erciyes University School of Medicine, Kayseri, Turkey
Rheumatol Int 27:955-60. 2007..The pathogenesis of Henoch Schonlein Purpura is incompletely understood and the role of chemokines is unknown...
- Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysemaMarina Miller
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0635, USA
J Allergy Clin Immunol 120:1118-25. 2007..We evaluated subjects with COPD and computed tomographic (CT) scan evidence of emphysema to determine the biomarker profile associated with a bronchodilator response...
- Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonideC Stellato
Division of Clinical Immunology and Allergy, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Immunol 163:5624-32. 1999..topical glucocorticoid budesonide differentially regulate RANTES, monocyte chemoattractant protein-4 (MCP-4), and eotaxin mRNA and protein expression in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial ..
- Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytesPatricia Ogilvie
Institute for Research in Biomedicine, Via Vela 6, 6500 Bellinzona, Switzerland
Blood 102:789-94. 2003b>Eotaxin-3 (CCL26) belongs to the group of CC chemokines that attract eosinophils, basophils, and Th2 lymphocytes. Like eotaxin (CCL11) and eotaxin-2 (CCL24), eotaxin-3 mediates its activity through CCR3...
- Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patientsJi Won Min
Division of Allergy and Respiratory Diseases, Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University, Bucheon Hospital, Gyeonggi Do, Korea
Chest 128:3127-32. 2005..In the present study, the levels of eotaxin-1, eotaxin-2, and eotaxin-3 following an oral aspirin provocation test (APT) were measured, and the relationship ..
- Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migrationJ R White
Departments of Immunology, Biomolecular Discovery, Pulmonary Biology, Gene Expression Sciences, and Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
J Biol Chem 275:36626-31. 2000..Several CC chemokines including eotaxin (CCL-11), eotaxin-2 (CCL-24), RANTES (CCL-5), and monocyte chemotactic protein-3 (MCP-3, CCL-7) and 4 (MCP-4, CCL-..
- The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3P Loetscher
Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
J Biol Chem 276:2986-91. 2001..IP10 (interferon-inducible protein 10), is expressed preferentially on Th1 cells, whereas CCR3, the receptor for eotaxin and several other CC chemokines, is characteristic of Th2 cells...
- Cloning of equine chemokines eotaxin, monocyte chemoattractant protein (MCP)-1, MCP-2 and MCP-4, mRNA expression in tissues and induction by IL-4 in dermal fibroblastsC Benarafa
Department of Pathology and Infectious Diseases, The Royal Veterinary College, Hatfield, Hertfordshire AL9 7TA, UK
Vet Immunol Immunopathol 76:283-98. 2000We report the cloning of four equine CC chemokines, eotaxin, monocyte chemoattractant protein (MCP)-1, MCP-2 and MCP-4, which show high levels of identity with their respective homologous sequences in other species...
- [Effects of fasudil on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma.]Feng Qin Wu
Department of Respiratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
Zhonghua Jie He He Hu Xi Za Zhi 32:847-9. 2009..To explore the role of Rho kinase-1 (ROCK-1) in airway inflammation of asthma by observing the effects of fasudil, a specific inhibitor of ROCK-1, on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma...
- Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cellsXue Qiong Zhu
Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Gynecol Oncol 105:650-6. 2007..The purpose of this study was to reveal the different mast cell subsets in smooth muscle tumors of uterus and to investigate the mechanism of local increase of mast cells...
- Detection of mRNA for eotaxin-2 and eotaxin-3 in human dermal fibroblasts and their distinct activation profile on human eosinophilsY Dulkys
Hannover Medical University, Department of Dermatology and Allergology, Hannover, Germany
J Invest Dermatol 116:498-505. 2001..part in the pathogenesis of allergic and autoimmune diseases, the role of the recently discovered members of the eotaxin family, eotaxin-2 and eotaxin-3, is not really understood...
- Apoptotic eosinophils in sputum from asthmatic patients correlate negatively with levels of IL-5 and eotaxinJunyang Xu
Department of Respiratory Medicine, The Fifth Affiliated Hospital of Sun Yat sen University, Guangdong, China
Respir Med 101:1447-54. 2007..Eosinophilic inflammation of the airways is a key characteristic of asthma. A defect in eosinophil apoptosis might contribute to the chronic tissue eosinophilia associated with asthma...
- Differential roles of IL-18 in allergic airway disease: induction of eotaxin by resident cell populations exacerbates eosinophil accumulationE Campbell
Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 164:1096-102. 2000..A possible mechanism was observed in a significant increase in eotaxin, but not other eosinophil chemotactic factors, in bronchoalveolar lavage fluid after IL-18 instillation...
- Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophilsC K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
Clin Exp Immunol 128:483-9. 2002The CC chemokine eotaxin is a potent eosinophil-specific chemoattractant that is crucial for allergic inflammation. Allergen-induced tumour necrosis factor (TNF) has been shown to induce eotaxin synthesis in eosinophils...
- Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoproteinTeresa R Johnson
Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892 3017, USA
J Leukoc Biol 84:748-59. 2008..We now address the contributions of IL-5, eotaxin-1, and CD4+ and CD8+ T cells to the induction of disease-enhancing immune responses...
- Effects of antisense interleukin-5 gene transferred by recombinant adeno-associated virus to allergic ratsDaxiong Zeng
Department of Respiratory Medicine, Tongji Hospital, Key Laboratory of Pulmonary Diseases of Ministry of Health of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Respirology 15:132-40. 2010..This study explored a new approach to asthma therapy in which allergic rats were transfected with the IL-5 antisense gene delivered by the recombinant adeno-associated virus (rAAV-ASIL-5)...
- Nasal RANTES and eotaxin production pattern in response to rhinovirus infectionJens E Meyer
Department of Otorhinolaryngology, Head and Neck Surgery, University of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
Rhinology 44:140-4. 2006Tissue eosinophilia is a hallmark of nasal polyposis and its pathogenesis is an area of high interest. RANTES and eotaxin are both known to recruit eosinophils, however, the mechanisms triggering their induction are still uncertain, and ..
- Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitisAndrea Leonardi
Department of Ophthalmology, University of Padua, via Foscari 8, 35127 Padua, Italy
Ophthalmology 110:487-92. 2003b>Eotaxin-1 and eotaxin-2 are potent eosinophil chemotactic and activating peptides that may be implicated in the pathogenesis of the chronic allergic eye diseases vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC)...
- Nasal mucosal immunoexpression of the mast cell chemoattractants TGF-beta, eotaxin, and stem cell factor and their receptors in allergic rhinitisRami J Salib
Department of Respiratory Cell and Molecular Biology, Division of Asthma, Allergy and Inflammation, School of Medicine, University of Southampton, United Kingdom
J Allergy Clin Immunol 114:799-806. 2004..Allergic rhinitis is characterized by the epithelial accumulation of cells, particularly mast cells and eosinophils. There is little information relating to the chemotaxins responsible for mast cell epithelial accumulation in this disease...
- Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillanceLjubov Simson
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Mills Road Acton, Canberra, Australian Capital Territory, Australia
J Immunol 178:4222-9. 2007..fibrosarcomas in IL-5 transgenic mice that have greatly enhanced levels of circulating eosinophils, CCL11 (eotaxin-1)-deficient mice that lack a key chemokine that recruits eosinophils into tissues, and the eosinophil-deficient ..
- Stem cell factor-induced leukotriene B4 production cooperates with eotaxin to mediate the recruitment of eosinophils during allergic pleurisy in miceA Klein
Immunopharmacology, Departamento de Bioquimica e Imunologia, Instituto Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
J Immunol 167:524-31. 2001..The intrapleural administration of the eosinophil-active chemokines eotaxin, RANTES, and macrophage-inflammatory protein 1alpha (MIP-1alpha) induced a time- and dose-dependent eosinophil ..
- Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infectionJonathan E Simons
School of Biological Sciences, University of Manchester, Manchester, UK
Eur J Immunol 35:189-97. 2005..contained in distinct anatomical compartments, in blood or tissue sites, we have demonstrated a critical role for eotaxin-1 in parasite clearance. In the first model, implantation of adult B...
- Short hairpin RNAs against eotaxin or interleukin-5 decrease airway eosinophilia and hyper-responsiveness in a murine model of asthmaHsin Ying Huang
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Gene Med 11:112-8. 2009Eosinophilia plays the major role in the pathogenesis of asthma and correlates with the up-regulation of eotaxin, which, together with interleukin (IL)-5, is important for differentiation, chemo-attraction, degranulation, and survival of ..
- TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNAKyoko Niimi
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
J Immunol 178:489-95. 2007..Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of ..
- Effect and mechanism of lipopolysaccharide on allergen-induced interleukin-5 and eotaxins production by whole blood cultures of atopic asthmaticsJ W Min
Genome Research Center for Allergy and Respiratory Diseases, Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Korea
Clin Exp Immunol 147:440-8. 2007Interleukin (IL)-5 and eotaxin families regulate the development of eosinophilic inflammation of asthma in a co-operative manner...
- IL-4 and TNF-alpha increased the secretion of eotaxin from cultured fibroblasts of nasal polyps with eosinophil infiltrationKousuke Yoshifuku
Department of Otolaryngology Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Rhinology 45:235-41. 2007..eosinophil-rich nasal polyps (Enp) and those with non-eosinophilic nasal polyps (NEnp) and the secreted levels of eotaxin, regulated upon activation normal T expressed and presumably secreted (RANTES), and vascular cell adhesion ..
- Regulatory mechanisms of galectin-9 and eotaxin-3 synthesis in epidermal keratinocytes: possible involvement of galectin-9 in dermal eosinophilia of Th1-polarized skin inflammationK Igawa
Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Allergy 61:1385-91. 2006..To investigate regulation of localization of eosinophils in skin, we examined the regulatory mechanisms of expression of eosinophil-specific chemoattractants in dermal fibroblasts and epidermal keratinocytes...
- Mycophenolate mofetil and triptolide alleviating airway inflammation in asthmatic model mice partly by inhibiting bone marrow eosinophilopoiesisHui Mao
Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, PR China
Int Immunopharmacol 8:1039-48. 2008..Airway inflammation, and inflammatory mediators IL-5 and eotaxin in the peripheral blood and bone marrow were measured by histology and ELISA...
- Chitin stimulates expression of acidic mammalian chitinase and eotaxin-3 by human sinonasal epithelial cells in vitroAshley Lalaker
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Rhinol Allergy 23:8-14. 2009..Although epithelial cells can also be induced by Th2 cytokines to express proeosinophilic mediators, no environmental agents have been identified that promote this effect...
- Eotaxin is required for the baseline level of tissue eosinophilsA N Matthews
Division of Pulmonary Medicine, Allergy, and Clinical Immunology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 95:6273-8. 1998b>Eotaxin is an eosinophil-selective chemokine that is constitutively expressed in a variety of organs such as the intestine...
- Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces human CC- and CXC-chemokines in vitro and in vivoY Luo
Department of Urology, University of Iowa, Iowa City, IA 52242, USA
Clin Exp Immunol 147:370-8. 2007..protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha and eosinophil chemoattractant activity (eotaxin)] and CXC-interferon-inducible protein (IP)-10 chemokine production in response to BCG stimulation...
- The kinetics of allergen-induced eotaxin level in nasal lavage fluid: its key role in eosinophil recruitment in nasal mucosaN Terada
Department of Otorhinolaryngology, Chiba University School of Medicine, Chiba, Japan
Am J Respir Crit Care Med 164:575-9. 2001b>Eotaxin (CCL11) is a potent eosinophil chemoattractant belonging to the C-C chemokine...
- Tyrosine sulfation influences the chemokine binding selectivity of peptides derived from chemokine receptor CCR3John Z Zhu
Interdisciplinary Program in Biochemistry, Indiana University, Bloomington, Indiana 47405, United States
Biochemistry 50:1524-34. 2011..responses of chemokine receptor CCR3 to different chemokines, we have studied the binding of three chemokines (eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26) to an N-terminal CCR3-derived peptide in each of its four possible ..
- The role of platelet-derived growth factor receptor in eotaxin signaling of eosinophilsTetsuya Adachi
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 140:28-34. 2006..It has recently been suggested that hypereosinophilic syndrome results from the fusion tyrosine kinase FIP1L1-PDGFRA. Although it is possible that the PDGFR signal is involved in eosinophil function, the details are still unclear...
- Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivoF J Culley
Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, South Kensington, London, United Kingdom
J Immunol 165:6447-53. 2000b>Eotaxin is a potent eosinophil chemoattractant that acts selectively through CCR3, which is expressed on eosinophils, basophils, mast cells, and Th2-type T cells...
- Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitroBolleddula Jayaprakasam
Departments of Pediatrics, Genetics and Genomics Science, and Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York City, New York 10029, USA
J Agric Food Chem 57:820-5. 2009..Airway eosinophilic inflammation is a major feature of allergic asthma. Eotaxin-1 (eotaxin) is involved in the recruitment of eosinophils to sites of antigen-induced inflammation in asthmatic ..
- Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil traffickingAnil Mishra
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 277:4406-12. 2002..expression by enterocytes, enterocyte transgenic mice that overexpressed the eosinophil-selective cytokines eotaxin and interleukin (IL)-5 were generated...
- Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1S Zhang
Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202, USA
J Immunol 162:4938-42. 1999..with other human CC chemokines, such as human macrophage inflammatory protein-1 alpha (hMIP-1 alpha) and eotaxin, which also use the CCR1 and CCR3 as their receptors...
- Eosinophil development and bone marrow and tissue eosinophils in atopic asthmaD S Robinson
Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
Int Arch Allergy Immunol 118:98-100. 1999Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma.
- Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammationJ Wang
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 165:4051-61. 2000..inflammation and eosinophilia, increased levels of IL-4, IL-5, and IL-13 protein and mRNA, exaggerated levels of eotaxin, JE/monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and -2, and mRNA, increased ..
- Differential histopathology and chemokine gene expression in lung tissues following respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV- or BBG2Na-immunized miceU F Power
Centre d Immunologie Pierre Fabre, 74164 Saint Julien en Genevois, France
J Virol 75:12421-30. 2001..At the molecular level, FI-RSV priming was characterized by a rapid and strong up-regulation of eotaxin and monocyte chemotactic protein 3 (MCP-3) relative gene expression (potent lymphocyte and eosinophil ..
- Shear-dependent eosinophil transmigration on interleukin 4-stimulated endothelial cells: a role for endothelium-associated eotaxin-3S L Cuvelier
Department of Biochemistry and Molecular Biology, Immunology Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
J Exp Med 194:1699-709. 2001..chain reaction (RT-PCR) and Western blots, we found that IL-4-stimulated HUVECs produce both mRNA and protein for eotaxin-3. Eotaxin-3 was both released by HUVECs and expressed on the endothelial cell surface...
- Differential expression of proinflammatory cytokine genes in vivo in response to pathogenic and nonpathogenic pneumovirus infectionsJoseph B Domachowske
Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
J Infect Dis 186:8-14. 2002..genes, and chemokines MCP-1, MCP-3, RANTES (regulated on activation, normally T cell-expressed and secreted), and eotaxin. Of these, only RANTES expression increased in response to infection with strain 15, with no increased expression ..
- Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cellsTadaatsu Imaizumi
Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
J Leukoc Biol 72:486-91. 2002..Interleukin-4, which induces eotaxin expression, did not affect the expression of galectin-9...
- Acute allergic responses induce a prompt luminal entry of airway tissue eosinophilsJonas S Erjefalt
Assoc Prof Department of Physiological Sciences, BMC F10, Lund University Hospital, 221 84, Lund, Sweden
Am J Respir Cell Mol Biol 29:439-48. 2003..Along with the allergen-induced egression of eosinophils, acute luminal entry of plasma proteins and eotaxin occurred...
- Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthmaE Rojas-Ramos
Dept of Allergy and Clinical Immunology, National Institute of Lung Diseases, Mexico DF, Mexico
Eur Respir J 22:310-6. 2003..the concentrations of MCP-4 and eosinophil numbers in BAL fluid and a trend between both chemokines MCP-3 and eotaxin-2 and eosinophils. Interestingly, the levels of most chemokines correlated with one another...
- Helminth infection modulates the development of allergen-induced airway inflammationGisela Wohlleben
Center for Infectious Diseases, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
Int Immunol 16:585-96. 2004..We found a decrease in allergen-induced airway eosinophilia and Eotaxin levels in the airways when mice were infected with the helminths 8 weeks, and especially 4 weeks, but not 1 or 2 ..
- Bovine eotaxin (CCL11)--an unusual member of the eotaxin group--attracts eosinophils in vitro but is not responsible for eosinophilia in the ovaryB Vogel
Department of Conservative Dentistry and Periodontology, University of Leipzig, Nürnberger Street 57, Leipzig D 04103, Germany
Vet Immunol Immunopathol 107:67-77. 2005..Currently, we only have a limited understanding of the mechanism for the recruitment of the ovarian eosinophils. Eotaxin (CCL11) may be one of the chemoattractants involved in stimulating eosinophils to migrate selectively into ovary...
- Pathophysiology and immunology of allergic bronchopulmonary aspergillosisR B Moss
Department of Pediatrics, Division of Pulmonary Medicine, Stanford University, Palo Alto, CA 94304 5786, USA
Med Mycol 43:S203-6. 2005..Chemotactic cytokines (e.g. IL-8, RANTES, eotaxin) in particular have been implicated in murine models...
- Quantification of mRNA encoding cytokines and chemokines in nasal biopsies from dogs with sino-nasal aspergillosisDominique Peeters
Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Liege, Boulevard de Colonster, 20, Sart Tilman B44, 4000 Liege, Belgium
Vet Microbiol 114:318-26. 2006..01) but there was no difference between groups with respect to IL-4, IL-5, IL-6, IL-12, TGF-beta, and eotaxin-2 and -3...
- Distribution of CCR3 mRNA expression in horse tissuesMarie C Weston
Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK
Vet Immunol Immunopathol 114:238-46. 2006CCL11 (also known as eotaxin) is a very potent and selective mediator of eosinophil migration which exerts its effects through its receptor, CCR3...
- Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammationKenichi Kitamura
Department of Medicine II, Faculty of Medicine, Okayama University Medical School, Okayama, Japan
J Immunol 178:480-8. 2007..However, numbers of eosinophils, levels of IL-5, IL-13, and eotaxin in bronchoalveolar lavage fluid, and mononuclear cell (MNC) proliferative responses to OVA were significantly ..
- Eosinophilic oesophagitis: epidemiology, clinical aspects, and association to allergyRasmus G Nielsen
H C Andersen Children s Hospital, Odense University Hospital, University of Southern Denmark, Odense
J Pediatr Gastroenterol Nutr 45:281-9. 2007..initially obtained from animal models, in particular with regard to the role of interleukin-5 and the chemokine eotaxin-1 in eosinophilic recruitment...
- Role of intracellular kinases in the regulation of equine eosinophil migration and actin polymerizationM C Weston
Department of Veterinary Basic Sciences and Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire, UK
J Vet Pharmacol Ther 31:31-8. 2008..These kinases represent potential targets for modulating eosinophil activation by multiple stimuli...
- Dietary perilla oil inhibits proinflammatory cytokine production in the bronchoalveolar lavage fluid of ovalbumin-challenged miceHui Hsiang Chang
Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung, 40227, Taiwan, ROC
Lipids 43:499-506. 2008..or the secretions of inflammatory mediators such as prostaglandin E2 (PGE2), histamine, nitric oxide and eotaxin. However, dietary perilla oil significantly (P < 0...
- Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthmaElizabeth Rose Walsh
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Exp Med 205:1285-92. 2008..by reduced T cell recruitment into the lung, as these mouse lungs had reduced expression of CCL7/MCP-3, CC11/eotaxin-1, and CCL24/eotaxin-2...
- Origin, regulation and physiological function of intestinal oeosinophilsPatricia C Fulkerson
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Best Pract Res Clin Gastroenterol 22:411-23. 2008..to the important role of the transcription factor GATA-1, the oeosinophil-selective cytokine IL-5 and the eotaxin subfamily of chemokines...
- Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosisMasakazu Umezawa
Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi 329 0112, Japan
Cytokine 43:105-9. 2008..study, we analyzed expression levels of interleukin (IL)-6, IL-10, monocyte chemoattractant protein-1, eosinophil chemotactic protein, macrophage inflammatory protein-1alpha, and regulated on activation normal T cell expressed and ..
- Ticks produce highly selective chemokine binding proteins with antiinflammatory activityMaud Deruaz
Merck Serono Geneva Research Centre, 1202 Geneva, Switzerland
J Exp Med 205:2019-31. 2008..and P.J. Hudson. 2005. Nat. Biotechnol. 23:1126-1136), and may be therapeutically useful as novel antiinflammatory agents in the future...
- Obesity and asthmaJ Delgado
Allergy Service, University Hospital Virgen Macarena, Sevilla, Spain
J Investig Allergol Clin Immunol 18:420-5. 2008..and secreted by cells from adipose tissue and receive the generic name of adipokines, including IL-6, IL-10, eotaxin, tumor necrosis factor-alpha, transforming growth factors-beta1, C-reactive protein, leptin, and adiponectin...
- Smoking affects eotaxin levels in asthma patientsAlgirda Krisiukeniene
Department of Pulmonology and Immunology, Kaunas University of Medicine, Kaunas, Lithuania
J Asthma 46:470-6. 2009..Chronic airway inflammation is most important pathological finding in asthma. Cigarette smoking may modify type of inflammation as well as may influence disease severity and response to the treatment...
- Involvement of galectin-9 in lung eosinophilia in patients with eosinophilic pneumoniaShigeki Katoh
Department of Cell Regulation, Faculty of Medicine, Kagawa University, Kagawa, Japan
Int Arch Allergy Immunol 153:294-302. 2010..The purpose of the present study is to clarify the role of Gal-9 in human eosinophilic pulmonary inflammation in comparison with eotaxin (CCL11).
- [Eosinophilic esophagitis]Dora Lippai
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 151:1225-31. 2010..Environmental (antigens) and genetic factors (eotaxin-3) have been reported to play role in the pathogenesis of the disease...
- Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patientsZiemowit Zietkowski
Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Respir Res 11:110. 2010Airway eosinophilia is considered a central event in the pathogenesis of asthma. Eotaxin plays a key role in selective eosinophil accumulation in the airways and, subsequently, their activation and degranulation...
- Reovirus virotherapy overrides tumor antigen presentation evasion and promotes protective antitumor immunityShashi A Gujar
Department of Pathology and Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Room 7 P, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 1X5
Mol Cancer Ther 9:2924-33. 2010..Furthermore, on exposure to reovirus, DCs produce IL-1α, IL-1β, IL-6, IL-12p40/70, IL-17, CD30L, eotaxin, GM-CSF, KC, MCP-1, MCP-5, M-CSF, MIG, MIP-1α, RANTES, TNF-α, VCAM-1, VSGF, CXCL-16, AXL, and MCP-2; undergo ..
- Dermal fibroblasts from acute inflamed atopic dermatitis lesions display increased eotaxin/CCL11 responsiveness to interleukin-4 stimulationN Gahr
Clinical Research Unit, Department of Dermatology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
Br J Dermatol 164:586-92. 2011..CCL11 is a potent chemoattractant and activator of human eosinophils and interleukin (IL)-4 is a potent inducer of CCL11 expression in dermal fibroblasts...
- 5A, an apolipoprotein A-I mimetic peptide, attenuates the induction of house dust mite-induced asthmaXianglan Yao
Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 186:576-83. 2011..These data support the conclusion that strategies using apoA-I mimetic peptides, such as 5A, might be developed further as a possible new treatment approach for asthma...
- Profibrotic phenotype of conjunctival fibroblasts from mucous membrane pemphigoidValerie P J Saw
Department of Ocular Biology and Therapeutics, University College London Institute of Ophthalmology, London, UK
Am J Pathol 178:187-97. 2011..03), increased secretion of matrix metalloproteinase-3 (P = 0.03), and increased secretion of eotaxin in response to interleukin-13 (P = 0.04)...
- Embryonic exposure to low concentration of bisphenol A affects the development of Oryzias melastigma larvaeQiansheng Huang
Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, People s Republic of China
Environ Sci Pollut Res Int 19:2506-14. 2011..melastigma. The larvae hatched from exposed embryos showed the foci of inflammation in the heart ventricles and the decrease of the body length and width...
- New biomarker for neovascular age-related macular degeneration: eotaxin-2Neel Kamal Sharma
Department of Neurology, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
DNA Cell Biol 31:1618-27. 2012Recently, eotaxin-CCR3 was reported to play an important role in choroidal neovascularization (CNV) development and was documented to be superior than vascular endothelial growth factor-A treatment when tested in CNV animals...
- Effects of small intestinal submucosa (SIS) on the murine innate immune microenvironment induced by heat-killed Staphylococcus aureusRoshni Roy Chowdhury
Department of Biology, Indiana State University, Terre Haute, Indiana, United States of America
PLoS ONE 7:e48724. 2012..aureus-SIS exposure also augmented the expressions of pro-inflammatory cytokines like IL-1β, Tnf-α, CD30L, Eotaxin and Fractalkine. This heightened inflammatory response caused by S...
- Effects of subchronic exposure to low-dose volatile organic compounds on lung inflammation in miceFan Wang
School of Environmental Science and Technology, Dalian University of Technology, Key Laboratory of Industrial Ecology and Environmental Engineering, MOE, Dalian 116024, China Department of Biological Science, Luoyang Normal University, Luoyang 471022, China
Environ Toxicol 29:1089-97. 2014..could increase significantly reactive oxygen species (ROS) in lung, the levels of interleukin-8 (IL-8), IL-4, eotaxin, nerve growth factor (NGF), and various types of leukocytes in BALF, IgE concentration in serum...
- Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 productionHuei Mei Huang
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
PLoS ONE 8:e63613. 2013..mice, OVA challenge induced lower OVA-specific immunoglobulin E (IgE) and higher IgG2a antibody production, lower eotaxin, keratinocyte-derived chemokine (KC), IL-5, and IL-13 release in bronchial alveolar lavage fluid, attenuated ..
- Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damageHelga Sanner
Section of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway Norwegian Competence Centre of Pediatric and Adolescent Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway
PLoS ONE 9:e92171. 2014....
- Suppressive activity of quercetin on the production of eosinophil chemoattractants from eosinophils in vitroMisako Sakai-Kashiwabara
Graduate School of Nursing and Rehabilitation Sciences, Showa University Graduate School, Yokohama, Japan
In Vivo 28:515-22. 2014..Chemokine, eotaxin, regulated on activation normal T cell expressed and secreted and macrophage inflammatory protein-1β, levels in ..
- Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signalingIn Hee Cho
Department of Food and Nutrition, Hallym University, Chuncheon, South Korea
BMC Pulm Med 14:122. 2014b>Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases...
- Osteopontin binds and modulates functions of eosinophil-recruiting chemokinesA Gela
Division of Respiratory Medicine and Allergology, Department of Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden
Allergy 71:58-67. 2016..Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28...
- Chemokine Expression Profiles of Human Hepatoma Cell Lines Mediated by Hepatitis B Virus X ProteinDi Yi Wang
Department of Pathology, Affiliated Hospital of Taishan Medical University, Taian, 271000, China
Pathol Oncol Res 22:393-9. 2016..IL-8) was obviously up-regulated, and epithelial neutrophil-activating protein 78 (ENA78), eosinophil chemotactic protein-1 (Eotaxin-1), monocyte chemotactic protein-1 (MCP-1), MCP-2, MCP-3 and macrophage inflammatory ..
- Eosinophil, Chemokine and IL-13 Cooperativity in AsthmaMARC ROTHENBERG; Fiscal Year: 2007..In particular, Th2 cell derived IL-13 promotes eotaxin production, which subsequently provides a critical signal for eosinophils to amplify IL-13 production (from ..
- MECHANISMS OF PULMONARY FIBROSISSem H Phan; Fiscal Year: 2010..of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin. Human pulmonary fibrosis and fibrosis of the airway walls in asthma are associated with significant influx of ..
- Mechanisms of Virus-Induced Hyperreactivity in AtopicsDavid B Jacoby; Fiscal Year: 2010..SPECIFIC AIM #2: To determine the regulation of eotaxin as well as other CCR3 ligands), ICAM-1, and VCAM expression in primary cultures of human and guinea pig airway ..
- Eosinophil ORMDL3 and allergic inflammationP Sriramarao; Fiscal Year: 2012..intracellular Ca2+ levels as well as exposure to mediators of allergic inflammation such as IL-3 (~10 fold) and eotaxin. Based on this observation, we hypothesize that ORMDL3 regulates Eos activation and potentially its adhesive ..
- Lori A Coburn; Fiscal Year: 2016..and in a prospectively collected cohort of adult patients with UC, our human serum profiling data indicate that eotaxin-1 may be a biomarker of disease activity in UC. Eotaxin-1 (CCL11) is a chemoattractant for eosinophils...
- PAK1's role in eotaxin-mediated murine eosinophil migrationMuithi M Mwanthi; Fiscal Year: 2012..b>Eotaxin induced by the allergic sensitization and challenge process powerfully recruits eosinophils to the lungs via CCR3 ..
- Mouse Models of Eosinophil-Associated Lung DysfunctionNancy A Lee; Fiscal Year: 2013..an allergen- naive double transgenic mouse (I5/hE2) that expresses IL-5 systemically from mature T cells and eotaxin-2 locally from lung epithelial cells...
- A multi-center clinical trial of 1760 mcg of daily swallowed fluticasone vs. placMarc E Rothenberg; Fiscal Year: 2010..we recently identified an EE transcriptome that includes the eosinophil chemoattractant and activating factor eotaxin-3 as the single most dysregulated gene in the esophagus of EE patients (7)...
- REGULATION OF CC CHEMOKINES IN HUMAN AIRWAY EPITHELIUMCristiana Stellato; Fiscal Year: 2004..demonstrated that airway epithelial cells are an important source of three major eosinophil-active chemokines, eotaxin, MCP-4, and RANTES, that glucocorticoids (GCs) inhibit production of these chemokines, and that both production ..
- Marc E Rothenberg; Fiscal Year: 2016..In the first grant cycle, we identified that eotaxin- 1 provides an essential signal for regulating the baseline and allergen-induced homing of eosinophils into the ..
- Eosinophil Peroxidase in Allergic InflammationArne Slungaard; Fiscal Year: 2012..Our second specific aim is to test the hypothesis that in a novel murine IL- 5/Eotaxin-2 (I5/E2) transgenic model of asthma, 1) crossbreeding with EPO-/- mice, 2) pharmacologic inhibition of EPO ..
- Therapeutic Vaccine for AsthmaPeter Blackburn; Fiscal Year: 2009..The eotaxin family of CC chemokines and the pro- inflammatory cytokines, IL-5 and IL-13, have been shown to specifically ..
- MECHANISMS OF CHEMOKINE EXPRESSION IN ASTHMACraig Lilly; Fiscal Year: 2003..b>Eotaxin is one substance that selectively activates these cell types...
- Marc B Hershenson; Fiscal Year: 2014..combined neutrophilic and eosinophilic response that is mediated in part by macrophage production of eotaxin-1/CCL11 and MCP-1/CCL2...
- SIMON PATRICK HOGAN; Fiscal Year: 2015....
- Risk Factors and Biomarkers for Diagnosis &Treatment of Eosinophilic EsophagitisEVAN SAMUEL DELLON; Fiscal Year: 2013..are to validate our model of risk factors for diagnosis of EoE, and to assess the utility of serum levels of eotaxin-3 and IL-13 in diagnosis and monitoring of treatment of EoE...
- Roles of CC chemokine activity in mast cell responses and ocular allergySanta Jeremy Ono; Fiscal Year: 2012..reactions - and that might be suitable targets for treatments of ocular allergy - include the chemokines eotaxin-1 and MIP-1[unreadable], their respective receptors CCR3 and CCR1, and molecules regulated by these signals...
- Novel Use of Ketotifen (Mast Cell Stablizier)in Fibromyalgia: A Pilot StudyDENNIS CHUA ANG; Fiscal Year: 2012..Interestingly, blood levels of chemokines (i.e., IL-8, MCP-1 and eotaxin) have been reported to be elevated in patients with FM...
- Kalipada Pahan; Fiscal Year: 2016..However, the mechanism behind disease progression is poorly understood. We hypothesize that RANTES and eotaxin could hold the key for driving disease progression and that targeting these two chemokines may be an important ..
- A Bifunctional Katp Channel Activator and Redox Mimetic for BPDKanneganti Murthy; Fiscal Year: 2013..Trichrome staining for collagen), R- 801 levels, and the protein expression of pro-inflammatory genes, including eotaxin, G-CSF, GM-CSF, IFN-?, IL-1[unreadable], IL-2, IL4, IL-3, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70),..
- The Role of Mast Cells in Lung InflammationJoshua Boyce; Fiscal Year: 2006..Finally, co-stimulation of hMC with both IgE receptor cross-linkage and the recombinant CCR3 ligand eotaxin-1 selectively amplifies the generation of IL-13 and induces IL-4 production de novo...
- HIV CORECEPTORS EXPRESSED BY GLIAL CELLSMartin Dorf; Fiscal Year: 2000..convincing data that demonstrate that mouse astrocytes migrate in response to chemokines like MIP-1 alpha and eotaxin and that those chemokine receptors are expressed in glia...
- Novel agonists and antagonists of chemokine receptorsTheo Devos; Fiscal Year: 2002..In phase I studies, we propose to establish the feasibility of this approach using the CCR3 receptor and eotaxin, a specific agonist of CCR3, to screen for novel CCR3 agonist and antagonist peptides...
- Novel minimally invasive assessment of gastrointestinal inflammation in food alleGlenn Furuta; Fiscal Year: 2009..of plasma, esophageal mucosa (biopsy) and luminal (EST) CD23, FceRI, tryptase, Th1 and Th2 cytokines, eotaxin-3, and eosinophil granule protein biomarkers to correlate changes with treatment-induced responses...
- VIRAL EXACERBATIONS OF ASTHMAScherer Sanders; Fiscal Year: 2002..will test the hypothesis that virus induced production of the eosinophil chemotactic and activating cytokines, eotaxin, RANTES, and granulocyte-macrophage colony stimulating factor (GM-CSF) from infected epithelial cells plays a ..
- Genetics of Eosinophilic EsophagitisNing Wang; Fiscal Year: 2007..Specifically, we will focus on two genes, eotaxin-3 and cadherin-like 26 in the proposed study. Specific Aim 1 Test the association of the eotaxin-3 gene with EE...
- CCR3: a molecular marker for neovascular AMDJayakrishna Ambati; Fiscal Year: 2010..Targeting CCR3 or its eotaxin ligands inhibited angiogenesis in vitro and in vivo, and was both superior to and safer than VEGF-A blockade...
- Early Immune Events in Childhood AsthmaLisa Miller; Fiscal Year: 2009..In addition, we have found that the expression of eotaxin-3/CCL26 within airway epithelium is significantly associated with eosinophilia following allergen challenge...
- Eosinophil Regulation of Pulmonary IL-13 LevelsElizabeth Jacobsen; Fiscal Year: 2007..hypothesis will be tested using a novel double transgenic mouse model of chronic asthma co- expressing IL-5 and eotaxin 2 (I5/E2) that replicates the pulmonary eosinophilia characteristic of asthma patients, including evidence of ..
- MECHANISMS OF EOSINOPHILIA IN EXPERIMENTAL ASTHMAMARC ROTHENBERG; Fiscal Year: 2002..based on the hypothesis that eosinophilic airway inflammation (characteristic of asthma) is mediated in part by eotaxin, a CC chemokine that specifically recruits and activates gene expression in eosinophils...
- MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2016..abstract_text> ..
- Determining the rap1b signaling pathway to integrin activation in plateletsLUIS ALBERTO PANIAGUA; Fiscal Year: 2012..that pancreatic [unreadable] cells of both DRIyp/lyp and DR+/+ strains recruit immune cells through expression of eotaxin, an eosinophil and mast cell recruiting chemokine, as well as interleukin 1[unreadable] prior to insulitis in the ..
- WILLIAM TZU LUNG HU; Fiscal Year: 2016..including Tau phosphorylation, tripeptidyl peptidase 1 (TPP1) levels, and inflammatory protein levels (FAS, eotaxin-3, IL-23), with 85% accuracy in distinguishing between the two main FTLD subtypes...
- RNA-binding Protein HuR in Allergic InflammationCristiana Stellato; Fiscal Year: 2009..We found that production of the CC chemokine eotaxin triggered by IL-4 and TNFa in human airway epithelial cells relies on the stabilization of the eotaxin mRNA, and ..
- Membrane Protein Production Using the Yeast SPP SystemNANCY ANN WOYCHIK; Fiscal Year: 2013..the first generation yeast SPP system using Saccharomyces cerevisiae and the MazF toxin by producing human eotaxin as a model target protein. Comparison with NMR data from eotaxin produced by yeast SPP vs...
- Saul A Villeda; Fiscal Year: 2016....
- Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in AsthmaMichelle Zeidler; Fiscal Year: 2007..will be evaluated using: 1) messenger ribonucleic acid (mRNA) measures of inducible nitric oxide synthase, eotaxin, rantes, and interleukin-4 (IL-4) receptor alpha in distal airways obtained via distal lung brushings; and 2) ..
- ENDOGENOUS MECHANISMS REGULATING AIRWAY INFLAMMATIONRobert Schleimer; Fiscal Year: 2003..an 11beta-HSD inhibitor to potentiate the inhibitory effects of cortisol on the secretion of GM-CSF, RANTES and eotaxin. Mechanistic studies in this aim will utilize 11beta-HSD-transfected cells to establish specificity of observed ..
- Opioid Binding to U51: A Human herpes Virus ProteinJean Bidlack; Fiscal Year: 2002..HHV-6 U51 is a chemokine receptor, which binds the chemokine RANTES, and other beta chemokines, such as eotaxin, monocyte chemoattractant protein 1, 3, and 4...
- CHEMOKINE BIOMARKERS OF DIISOCYANATE OCCUPATIONAL ASTHMADavid Bernstein; Fiscal Year: 2002..BAL fluids will be assayed for MCP- l,eotaxin, RANTES, IL-8, TNF-alpha, IL-1, IL-2, IL-4 and IL-5 and BAL cells will be phenotypically characterized and and ..
- Transgenic Mouse Model for Adenosine-induced AsthmaTehsheng Chan; Fiscal Year: 2003..expressed at the highest levels include TARC (thymus activated and regulated cytokine), JE/MCP- 1, KC/GRO 1, and eotaxin. Some of these genes are known to also play a role in allergic asthma, suggesting that adenosine-induced, Th2-..
- Mechanisms of Eosinophil AdhesionXiangdong Zhu; Fiscal Year: 2006..Ras activation is required for eosinophil adhesion, we will determine the effects of Ras inhibition on IL-5 or eotaxin- stimulated eosinophil adhesion and CD1 lb avidity change, using pharmacological inhibitors and a dominant ..
- IRRITANT-INDUCED ASTHMA: EPIDEMIOLOGY AND PATHOGENESISJean Luc Malo; Fiscal Year: 2001..antagonists on the airway damage; 5) evaluate the role of airway epithelial chemokines such as RANTES and eotaxin in the inflammatory response...
- The Role of Tenascin in Neointimal FormationPrediman Shah; Fiscal Year: 2009..The antibody array and ELISA analyses of chronic hyperlipidemic plasma from the two mouse genotypes showed that eotaxin, a CC chemokine, is selectively upregulated by 4- to 5-fold in the TN/E groups when compared to apo E mice...
- Mechanisms Regulation Functions of Airway Smooth MuscleReynold Panettieri; Fiscal Year: 2007..factors IRF-1, STAT1 and STAT2, and differentially regulates the expression of CD38, IL-6, RANTES and eotaxin but not ICAM-1 via the autocrine action of secreted IFNbeta...
- STRUCTURE AND SPECIFICITY OF EXOTAXIN-CCR3 INTERACTIONSMartin Stone; Fiscal Year: 2005..chemokine-receptor binding and specificity? The work will focus on the specific interaction between the chemokine eotaxin and its receptor CCR3, which results in the recruitment of eosinophils, a feature of allergic and parasitic ..
- T CELL AND EOSINOPHIL RECRUITMENT IN LUNG FIBROSISANDREW TAGER; Fiscal Year: 2003..in determining this balance; and (3) investigate the role of Th2 cytokines, and the eosinophil chemoattractants eotaxin and LTB4 (leukotriene B4), in eosinophil recruitment in BLM- induced fibrosis...
- T CELLS & CHEMOKINES IN ALLERGIC PULMONARY INFLAMMATIONJames Maclean; Fiscal Year: 2000..The specific aims are: 1) To determine if antigen-specific T cell lines and clones can induce eotaxin production by endothelial and epithelial cell lines in vitro...
- IDENTIFICATION OF EOTAXIN-3 REGULATED GENES AND PROTEINS IN ALVEOLAR TYPE II CELLBarack Abonyo; Fiscal Year: 2009..of these cells in the airway is due to their attraction by CC (cystein-cystein) chemokines including CCL11 (eotaxin), CCL24 (eotaxin-2) and CCL26 (eotaxin-3)...
- STRUCTURE/ACTIVITY RELATIONSHIPS OF EOTAXINMartin Stone; Fiscal Year: 2001..b>Eotaxin is the only chemokine that specifically attracts eosinophils...
- Effects of Tobacco-Induced Mediators in Developing LungKathleen Haley; Fiscal Year: 2005..many mediators are probably affected by maternal smoking, we will focus on one proinflammatory chemokine, eotaxin, as a paradigm for effects of maternal smoking on lung development...
- AAIDCRC - MECHANISMS OF VIRUS-INDUCED ASTHMAWilliam Busse; Fiscal Year: 2000..The initial focus will be on regulated on activation normal T cell expressed and secreted (RANTES) eotaxin, IL-8, and granulocyte macrophage-colony stimulating factor (GM-CSF)...
- Novel agonists and antogonists of chemokine receptorsFREDERICK HAGEN; Fiscal Year: 2004..In phase I feasibility studies we developed an assay using the CCR3 receptor, and the chemokine eotaxin as a positive control. We also developed a peptide expression system, and initiated library screening...
- Mechanisms of Eosinophil Effector Functions in the LungJames Lee; Fiscal Year: 2009..to the pulmonarypathologies arising in a transgenic model of asthma generated by the co-expression of JJL-5 and eotaxin-2;(2) To define mechanisms of eosinophil effector functions responsible for the pulmonarypathologiesoccurring in ..
- Role of Eotaxin-3/CCL26 in Allergic AsthmaLisa Miller; Fiscal Year: 2008..Our laboratory has recently investigated eotaxin/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26 as chemokine mediators of allergen-induced eosinophil recruitment ..
- INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMAKIAN CHUNG; Fiscal Year: 2005..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
- Chemogenomics to Identify New Molecular Targets in PFWilliam Henderson; Fiscal Year: 2006..These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of AP-1/TGFBeta-driven profibrotic gene expression as novel therapies in PF patients. ..
- CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMINGHal Broxmeyer; Fiscal Year: 2005..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
- CORTICOSTEROID INDUCED APOPTOSIS IN AIRWAY EPITHELIUMSteven White; Fiscal Year: 2002..These data would help lead to new therapeutic ideas and modalities in the treatment of asthma to suppress inflammation while preventing mucosal damage. ..
- Interferon regulation of T-bet in airway smooth muscleCHERIE SINGER; Fiscal Year: 2008..This award will allow me to begin to ask novel questions about the secretory phenotype of ASM in this supportive research environment that is committed to furthering junior faculty development. ..
- Functional synergism in prevention of hormone refractory CaP by phytochemicalsJoseph Wu; Fiscal Year: 2007..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. [unreadable] [unreadable] [unreadable]..
- Regulation of Inflammation in Asthma by Fas LigandAngela Haczku; Fiscal Year: 2009..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
- Environmental factors in the etiology of glaucomaJohn Schenkman; Fiscal Year: 2006..Our hypothesis has the potential to clarify the basic mechanisms of developmental toxicity operating during eye development and provides an opportunity to develop screening panels for assessment of ocular toxicity. ..
- Novel target proteins of resveratrol in chemopreventionJoseph Wu; Fiscal Year: 2005..abstract_text> ..
- EOSINOPHIL PROTEINS AND GASTROINTESTINAL DISEASEGlenn Furuta; Fiscal Year: 2003..EDGP stimulated epithelial cell chloride ion secretion and 3. EDGP stimulated neutrophil infiltration, changes in vascular permeability and fluid secretion in vivo. ..
- Regulation of airway epithelial repairSteven R White; Fiscal Year: 2010....
- ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILSDavid Broide; Fiscal Year: 2002..knockout mice whose eosinophils do not express the adhesion molecule sLex), and transmigration of eosinophils (eotaxin knockout mice) across endothelium...
- Dissection of cellular interactions with integrated functional genomics in compleMartin Hessner; Fiscal Year: 2008..Understanding the relationship between mast cells, T effector, and TREG cells in autoimmunity and has the potential to establish a new paradigm for immune regulation and create new insights to human disease. ..
- Early Life Exposure to Microbial Products and AsthmaJoel Kline; Fiscal Year: 2005..Question 2A: What mediators promote immune tolerance induced by early life exposure to microbial products? Question 2B: What cells are responsible for immune tolerance induced by early life exposure to microbial products? ..
- Regulation of Ongoing InflammationDaniel Remick; Fiscal Year: 2009..Successful completion of each of these specific aims will help to determine both the optimal method to regulate ongoing inflammation and the precise mechanisms of how this regulation occurs. ..
- Fine mapping of an Asthma Locus of Chromosome 12qBenjamin Raby; Fiscal Year: 2007..Identification of these variants may have a significant impact on the public health of asthma patients. ..