EOMES

Summary

Gene Symbol: EOMES
Description: eomesodermin
Alias: TBR2, eomesodermin homolog, T-box brain protein 2
Species: human

Top Publications

  1. ncbi Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:1236-44. 2005
  2. doi Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors
    Patricia Ribeiro-Dos-Santos
    INSERM, Unit 1020, Medical Faculty Déscartes, Paris, France
    Blood 119:4928-38. 2012
  3. doi HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127
    Rebecca B Hasley
    aCMRS Laboratory of Immunoregulation, NIAID bExperimental Immunology Branch, NCI, NIH, Bethesda cLaboratory of Molecular Immunoregulation, NCI, NIH, Frederick dBiostatistics Research Branch, NIAID, NIH, Bethesda eCollaborative Clinical Research Branch, NIAID, NIH, Frederick, Maryland, USA
    AIDS 27:1867-77. 2013
  4. pmc Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex
    Uladzislau Ivaniutsin
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK
    Neural Dev 4:3. 2009
  5. ncbi A starfish homolog of mouse T-brain-1 is expressed in the archenteron of Asterina pectinifera embryos: possible involvement of two T-box genes in starfish gastrulation
    E Shoguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Dev Growth Differ 42:61-8. 2000
  6. ncbi PTHrP promotes murine secondary trophoblast giant cell differentiation through induction of endocycle, upregulation of giant-cell-promoting transcription factors and suppression of other trophoblast cell types
    Ahmed H K El-Hashash
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Differentiation 73:154-74. 2005
  7. ncbi Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip
    Andrew J Fink
    Department of Pathology Neuropathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:3066-76. 2006
  8. doi Developmental potential of rat extraembryonic stem cells
    Vasiliy Galat
    Developmental Biology Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Stem Cells Dev 18:1309-18. 2009
  9. doi Germ layer patterning in bichir and lamprey; an insight into its evolution in vertebrates
    Masaki Takeuchi
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Hyogo 650 0047, Japan
    Dev Biol 332:90-102. 2009
  10. ncbi Genomic profiling identifies alterations in TGFbeta signaling through loss of TGFbeta receptor expression in human renal cell carcinogenesis and progression
    John A Copland
    Internal Medicine Department, University of Texas Medical Branch, Galveston, TX 77555, USA
    Oncogene 22:8053-62. 2003

Research Grants

  1. Ming Li; Fiscal Year: 2014
  2. LAURA MARY MCLANE; Fiscal Year: 2014
  3. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Michael W Miller; Fiscal Year: 2010
  4. CYTOTOXIC T LYMPHOCYTE ACTIVATION IN VITRO AND IN VIVO
    MATTHEW FRANKLIN MESCHER; Fiscal Year: 2013
  5. Arnob Banerjee; Fiscal Year: 2014
  6. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Frank A Middleton; Fiscal Year: 2013
  7. MATTHEW EUGENE PIPKIN; Fiscal Year: 2015
  8. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013
  9. Regulation of exhaustion and altered CD8 T cell memory during chronic Infection
    E John Wherry; Fiscal Year: 2010
  10. Generation and Regulation of Anti-Viral CD4 T Cells with Cytolytic Potential
    Deborah M Brown; Fiscal Year: 2013

Detail Information

Publications207 found, 100 shown here

  1. ncbi Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:1236-44. 2005
    ..Therefore, these key transcription factors link the long-term renewal of memory CD8(+) T cells to their characteristic effector potency...
  2. doi Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors
    Patricia Ribeiro-Dos-Santos
    INSERM, Unit 1020, Medical Faculty Déscartes, Paris, France
    Blood 119:4928-38. 2012
    ....
  3. doi HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127
    Rebecca B Hasley
    aCMRS Laboratory of Immunoregulation, NIAID bExperimental Immunology Branch, NCI, NIH, Bethesda cLaboratory of Molecular Immunoregulation, NCI, NIH, Frederick dBiostatistics Research Branch, NIAID, NIH, Bethesda eCollaborative Clinical Research Branch, NIAID, NIH, Frederick, Maryland, USA
    AIDS 27:1867-77. 2013
    ....
  4. pmc Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex
    Uladzislau Ivaniutsin
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK
    Neural Dev 4:3. 2009
    ..We examined the consequences of loss of Apc function for the early development of the cerebral cortex...
  5. ncbi A starfish homolog of mouse T-brain-1 is expressed in the archenteron of Asterina pectinifera embryos: possible involvement of two T-box genes in starfish gastrulation
    E Shoguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Dev Growth Differ 42:61-8. 2000
    ..These observations suggest implication of the two T-box genes, with different roles, in starfish gastrulation...
  6. ncbi PTHrP promotes murine secondary trophoblast giant cell differentiation through induction of endocycle, upregulation of giant-cell-promoting transcription factors and suppression of other trophoblast cell types
    Ahmed H K El-Hashash
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Differentiation 73:154-74. 2005
    ..of other trophoblast cell types by suppressing trophoblast progenitors and spongiotrophoblast-promoting factors, Eomes, Mash-2, and mSNA...
  7. ncbi Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip
    Andrew J Fink
    Department of Pathology Neuropathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:3066-76. 2006
    ..The rhombic lip-derived cells express transcription factors Pax6, Tbr2, and Tbr1 sequentially as they enter the NTZ...
  8. doi Developmental potential of rat extraembryonic stem cells
    Vasiliy Galat
    Developmental Biology Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Stem Cells Dev 18:1309-18. 2009
    ..for AP, SSEA1, Oct4, and Rex1 markers similar to ES cells and also express signature markers of TS-eomesodermin (Eomes) and XEN-Gata6...
  9. doi Germ layer patterning in bichir and lamprey; an insight into its evolution in vertebrates
    Masaki Takeuchi
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Hyogo 650 0047, Japan
    Dev Biol 332:90-102. 2009
    ..Eomesodermin (eomes), but not VegT, orthologs are expressed maternally in these animals, suggesting that VegT is a maternal factor for ..
  10. ncbi Genomic profiling identifies alterations in TGFbeta signaling through loss of TGFbeta receptor expression in human renal cell carcinogenesis and progression
    John A Copland
    Internal Medicine Department, University of Texas Medical Branch, Galveston, TX 77555, USA
    Oncogene 22:8053-62. 2003
    ..We also observed subsequent loss of type II TGFbeta receptor (TBR2) expression in metastatic RCCs...
  11. ncbi Overlapping expression of zebrafish T-brain-1 and eomesodermin during forebrain development
    M Mione
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Mech Dev 100:93-7. 2001
    ..in largely overlapping domains in the dorsal telencephalon, tbr1 is expressed in postmitotic cells whereas eomes is also expressed in proliferative ventricular zone cells...
  12. doi Response of osteogenic sarcoma to neoadjuvant therapy: evaluated by 18F-FDG-PET
    Zhaoming Ye
    Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Ann Nucl Med 22:475-80. 2008
    ....
  13. pmc Eomesodermin requires transforming growth factor-beta/activin signaling and binds Smad2 to activate mesodermal genes
    Paola Picozzi
    Department of Pediatrics, Division of Cardiology, Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 284:2397-408. 2009
    The T-box gene Eomesodermin (Eomes) is required for early embryonic mesoderm differentiation in mouse, frog (Xenopus laevis), and zebrafish, is important in late cardiac development in Xenopus, and for CD8+ T effector cell function in ..
  14. ncbi DNA methylation profiling of transcription factor genes in normal lymphocyte development and lymphomas
    Claudia Ivascu
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Int J Biochem Cell Biol 39:1523-38. 2007
    ..For some genes, such as SPI1, Etv5 and Eomes, we found an inverse correlation between the methylation of the 5' untranslated region and expression of the ..
  15. ncbi Dissecting the molecular hierarchy for mesendoderm differentiation through a combination of embryonic stem cell culture and RNA interference
    Naoki Izumi
    Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Stem Cells 25:1664-74. 2007
    ..Here, in combination with the RNA interference-mediated gene knockdown (KD) method, we show that Eomesodermin (Eomes), Mixl1, Brachyury (T), and GATA6 are major molecular determinants in the differentiation of mesendoderm, DE, VE, ..
  16. doi Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis
    Laurent Roybon
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 22184 Lund, Sweden
    Eur J Neurosci 29:232-43. 2009
    ..Furthermore, we reveal that Ngn2-positive progenies express the T-box transcription factors Tbr2 and Tbr1, which are usually present during cortical and hippocampal glutamatergic neuronal differentiation...
  17. pmc Kinetics of the immune response profile in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobacterium tuberculosis
    Ajay Grover
    Colorado State University, Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA
    Infect Immun 77:4837-46. 2009
    ..Our data suggest that day 40 postinfection may be a pivotal time point in determining vaccine efficacy and prolonged survival and that BCG promotes the capacity of T cells in the lungs to respond to infection...
  18. doi Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes
    Tânia Cristina Leite de Sampaio e Spohr
    Laboratório de Neurobiologia Celular, Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Neurosci Res 88:530-41. 2010
    ..the neuronal population positive for the neuronal marker beta-tubulin III and the neuronal transcriptional factor Tbr2 by approximately 20%. This event was followed by a 50% decrease in neuronal death...
  19. doi ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta
    Myriam Hemberger
    Laboratory for Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    Hum Mol Genet 19:2456-67. 2010
    ..ELF5 establishes a circuit of mutually interacting transcription factors with CDX2 and EOMES, and the highly proliferative ELF5(+)/CDX2(+) double-positive subset of cytotrophoblast cells demarcates a ..
  20. pmc IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
    Christian S Hinrichs
    National Cancer Institute, Surgery Branch, National Institutes of Health, Bethesda, MD 20892 1502, USA
    Blood 111:5326-33. 2008
    ..We found that antigen-induced expression of Eomesodermin (Eomes) and maturation of naive CD8(+) T cells into granzyme B- and CD44-expressing effector CD8(+) T cells was enhanced ..
  21. pmc Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse
    Sharon W Way
    Division of Medical Genetics, Department of Pediatrics, University of Texas Health Science Center, Houston, TX 77030, USA
    Hum Mol Genet 18:1252-65. 2009
    ..Developmental analysis demonstrated that loss of Tsc2 increased the subventricular Tbr2-positive basal cell progenitor pool at the expense of early born Tbr1-positive post-mitotic neurons...
  22. pmc Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory
    Pujya Agarwal
    Center for Immunology and Department of Laboratory, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1695-704. 2009
    ....
  23. ncbi Influences of extracellular matrix and of conditioned media on differentiation and invasiveness of trophoblast stem cells
    T Lei
    Institut fur Anatomie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Placenta 28:14-21. 2007
    ..Marker gene expression (Eomes, Pl-1, Tpbp) and invasion assays showed that TS cells exhibit increased invasive capacity when differentiating ..
  24. pmc The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone
    Xiuxin Liu
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:11802-7. 2008
    ..of dividing cells (basal or intermediate neuronal progenitors, INPs), recognized by their immunoreactivity to Tbr2, detach from the ventricular surface and migrate a short distance to establish a secondary proliferative ..
  25. pmc Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation
    Kirsten Huck
    Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, Heinrich Heine University, Dusseldorf, Germany
    J Clin Invest 119:1350-8. 2009
    ..Because ITK deficiency resembles EBV-associated lymphoproliferative disorders in boys, we suggest that this molecular cause should be considered during diagnosis and treatment...
  26. pmc Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation
    Dongmei Zhu
    Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 4:e7684. 2009
    ..These results suggest that Mbd3 helps restrict ES cells from differentiating towards the trophectoderm lineage and is an important epigenetic player in maintaining full pluripotency of mouse ES cells...
  27. doi Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex
    Lilla M Farkas
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Neuron 60:40-55. 2008
    ..the basal (rather than apical) side of the ventricular zone and induced expression of the basal progenitor marker Tbr2. Remarkably, these cells remained negative for Tis21, a marker of neurogenic progenitors, and did not generate ..
  28. pmc Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo
    Agnieszka Jedrusik
    The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Dev Biol 344:66-78. 2010
    ..Furthermore, expression of trophectoderm-specific genes, Gata3 and Eomes, and also the trophectoderm-specific cytokeratin intermediate filament, recognised by Troma1, are greatly reduced ..
  29. pmc Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation
    Reid S Alisch
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Genet 3:e227. 2007
    ....
  30. ncbi The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation
    Ashley E E Bruce
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Development 130:5503-17. 2003
    ..We have cloned and characterized a maternal T-box gene in the zebrafish, eomesodermin (eomes). During oogenesis, the eomes transcript becomes localized to the cortex of the oocyte...
  31. doi T-bet and eomesodermin are required for T cell-mediated antitumor immune responses
    Yibei Zhu
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 185:3174-83. 2010
    ..T-bet and Eomesodermin (Eomes) have been suggested to be master regulators of Th1 cells and CD8(+) T cells...
  32. ncbi Molecular basis for Bacillus thuringiensis Cry1Ab toxin specificity: two structural determinants in the Manduca sexta Bt-R1 receptor interact with loops alpha-8 and 2 in domain II of Cy1Ab toxin
    Isabel Gomez
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia UNAM, Apdo Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Biochemistry 42:10482-9. 2003
    ..residues 831-900 containing the (865)NITIHITDTNN(875) epitope (TBR1) and the other comprised of residues 1291-1360 (TBR2) were cloned by RT-PCR and produced in Escherichia coli...
  33. ncbi Sequence variation in the cadherin gene of Ostrinia nubilalis: a tool for field monitoring
    Brad S Coates
    USDA ARS, Corn Insects and Crop Genetics Research Unit, 113 Genetics Laboratory, Iowa State University, Ames, IA 50011, USA
    Insect Biochem Mol Biol 35:129-39. 2005
    ..nubilalis cadherin gene sequences identified variance within proposed Cry1A toxin binding region 2 (TBR2), 1328IPLQTSILVVT[I/V] N1340, and flanking Cry1A toxin binding region 1 (TBR1), 861DIEIEIIDTNN871...
  34. ncbi Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    Dan Strumpf
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
    Development 132:2093-102. 2005
    ..However, a positive regulator of TE cell fate has not been described. The T-box protein eomesodermin (Eomes) and the caudal-type homeodomain protein Cdx2 are expressed in the TE, and both Eomes and Cdx2 homozygous mutant ..
  35. ncbi Expression profiling of genes crucial for placental and preimplantation development in bovine in vivo, in vitro, and nuclear transfer blastocysts
    Vanessa J Hall
    Centre for Early Human Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Mol Reprod Dev 72:16-24. 2005
    ..expression of eight genes critical for early placental and preimplantation development including Acrogranin, Cdx2, Eomes, ErbB3, ERR2, Hand1, MRJ, and Rex1 were analyzed in single, in vivo, in vitro, and cloned bovine blastocysts (..
  36. ncbi Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation
    Naofumi Takemoto
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 177:7515-9. 2006
    ..Little is known, however, about how cytokines regulate expression of T-bet and eomesodermin (Eomes) in effector and memory CD8+ T cells...
  37. ncbi Identification of self-replicating multipotent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression
    Onur Basak
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Eur J Neurosci 25:1006-22. 2007
    ..However, Tbr2-positive basal progenitors of the developing telencephalon and differentiating Islet1/2- and Lim1-positive motor ..
  38. ncbi Cadherin inhibition of beta-catenin signaling regulates the proliferation and differentiation of neural precursor cells
    Stephanie R Noles
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Mol Cell Neurosci 35:549-58. 2007
    ..as demonstrated by altered expression of the radial glial marker, Pax6, and the intermediate precursor marker, Tbr2. Moreover, clonal analysis demonstrated asymmetric distribution of Tbr2 following precursor mitosis...
  39. pmc A molecular neuroanatomical study of the developing human neocortex from 8 to 17 postconceptional weeks revealing the early differentiation of the subplate and subventricular zone
    Nadhim Bayatti
    School of Clinical Medical Sciences, Department of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Cereb Cortex 18:1536-48. 2008
    ..5 PCW reflected in transcription factor expression patterns, including TBR2 confined to the inner subventricular and outer ventricular zones and TBR1 weakly expressed in the subventricular ..
  40. doi Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice
    Zishu Pan
    Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Dev Dyn 237:316-27. 2008
    ..trophoblast markers including Tpbp, Gcm1, and Pl-1, and increased expression of the trophoblast stem cell marker Eomes. Alkbh1 localizes to nuclear euchromatin, and interacts strongly with Mrj, an essential placental gene that ..
  41. doi Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression
    Thomas Mueller
    Department of Biopharmaceutical Sciences and Programs in Human Genetics, University of California, San Francisco, California 94143 2811, USA
    J Comp Neurol 507:1245-57. 2008
    We examined the brain expression patterns of zebrafish genes Lhx6, Lhx7, Dlx2a, GAD67, and Tbr2/eomesa; except for GAD67, expression domains are restricted to the forebrain...
  42. pmc Neurovascular congruence during cerebral cortical development
    Daniel Stubbs
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Cereb Cortex 19:i32-41. 2009
    ..analysis of vascular development in the embryonic murine cortex and demonstrate that dividing cells, including Tbr2-positive intermediate progenitor cells, are closer to the vasculature than expected from a random distribution...
  43. doi Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Bowel Dis 16:559-67. 2010
    ..In the present study we aimed at assessing the role of perforin-dependent effector mechanisms in the immune response in a murine model of colitis-associated colon cancer...
  44. doi Zygotic VegT is required for Xenopus paraxial mesoderm formation and is regulated by Nodal signaling and Eomesodermin
    Masakazu Fukuda
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan
    Int J Dev Biol 54:81-92. 2010
    ..The results of in vitro binding and functional assays indicate that Forkhead box H1 (FoxH1) and Eomesodermin (Eomes) are the trans-acting factors required for zVegT expression...
  45. pmc Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell
    Qian Qi
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 286:138-46. 2011
    ....
  46. pmc Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development
    Diane C Darland
    University of North Dakota, Department of Biology, Grand Forks, ND 58202, USA
    Dev Biol 358:9-22. 2011
    ..We quantified changes in PHH3-positive nuclei, neural stem cell markers (Pax6 and nestin) and the Tbr2-positive intermediate progenitors at E11.5 when the neural precursor population is expanding rapidly...
  47. pmc Crosstalk between TGF-beta and MAPK signaling during corneal wound healing
    Kazuto Terai
    Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45267 0838, USA
    Invest Ophthalmol Vis Sci 52:8208-15. 2011
    ..The aim of this study was to elucidate the mechanisms governing epithelial cell migration and proliferation during wound healing...
  48. pmc Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons
    Rebecca D Hodge
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98101, USA
    J Neurosci 32:6275-87. 2012
    ..Here we show that Tbr2 (also known as Eomes), a T-box transcription factor expressed by intermediate neuronal progenitors (INPs), is critically required for ..
  49. pmc Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb
    Rumiko Mizuguchi
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 32:8831-44. 2012
    ..T-box transcription factor Tbr2 is expressed in various types of glutamatergic excitatory neurons in the brain including the OB projection neurons, ..
  50. doi Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells
    Corey Smith
    Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, Queensland Institute of Medical Research, Brisbane, Australia
    Blood 120:3237-45. 2012
    T-box transcription factors T-bet (Tbx21) and Eomesodermin (Eomes) are critical players in CD8(+) cytotoxic T lymphocyte effector function and differentiation, but how the expression of these transcription factors is regulated remains ..
  51. pmc Pax6 regulates Tbr1 and Tbr2 expressions in olfactory bulb mitral cells
    Fumiaki Imamura
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell Neurosci 54:58-70. 2013
    ..Unlike cortical projection neurons, postmitotic mitral cell precursors express both Tbr1 and Tbr2. Our tracking experiments revealed that down-regulation of Pax6 preceded up-regulation of Tbrs, and that Tbr1 ..
  52. pmc The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 27:997-1002. 2013
    ..Here we demonstrate that the T-box gene Eomesodermin (Eomes) plays an essential role in AVE recruitment, in part by directly activating the homeobox transcription factor Lhx1...
  53. doi Characterization of enhancers active in the mouse embryonic cerebral cortex suggests Sox/Pou cis-regulatory logics and heterogeneity of cortical progenitors
    Amandine Bery
    Equipe Development and Evolution of the Forebrain
    Cereb Cortex 24:2822-34. 2014
    ..Finally, the combination of in utero electroporation of GFP reporter constructs with immunostaining for Tbr2 (basal progenitor marker) and phospho-histoneH3 (mitotic activity marker) demonstrated that each enhancer is ..
  54. doi CD28 controls the development of innate-like CD8+ T cells by promoting the functional maturation of NKT cells
    Mitra Yousefi
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, Canada
    Eur J Immunol 43:3017-27. 2013
    ..These findings reveal a previously unappreciated mechanism by which CD28 controls NKT-cell homeostasis and the size of the innate-like CD8(+) T-cell pool. ..
  55. pmc NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells
    Masaaki Hashiguchi
    Department of Immunology, School of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    Cytotechnology 66:373-82. 2014
    ..The transduction of GATA-3 decreased the expression of Tbx21 and Eomes, but the additional transduction of RelA abrogated the decreased expression of GATA-3-induced Tbx21 and Eomes...
  56. doi Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus
    Tatsunori Seki
    Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160 8402, Japan
    J Comp Neurol 522:261-83. 2014
    ..GFP+ cells with Neurogenin2 expression were largely distributed in the VZ, whereas GFP+ cells with Tbr2 and NeuroD expressions were seen in the migratory stream and developing dentate gyrus...
  57. doi Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-β1 signaling
    Magali Grange
    Centre d immunologie de Marseille Luminy, Aix Marseille Universite, Marseille 13288, France
    J Immunol 191:3712-24. 2013
    ..granzyme B(+), IFN-γ(+), TNF-α(+), and CCL3(+), but not IL-2, and transcription factors T-bet and eomesodermin (Eomes)...
  58. doi Double deficiency for RORγt and T-bet drives Th2-mediated allograft rejection in mice
    Manije Sabet-Baktach
    Department of Surgery, University Hospital Regensburg, University of Regensburg, 93053 Regensburg, Germany
    J Immunol 191:4440-6. 2013
    ..Moreover, under IL-4 neutralizing conditions, alloreactive double-deficient T cells upregulated Eomesodermin (Eomes) and IFN-γ, but not GATA-3...
  59. pmc Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors
    Takahito Yumoto
    Laboratory for Molecular Neurobiology, Graduate School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan
    PLoS ONE 8:e79895. 2013
    ..a reduction in NSPC proliferation and a concomitant increase in cell cycle exit, causing a reduction in the Tbr2-positive basal progenitor population and shrinkage of the embryonic subventricular zone...
  60. doi Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling
    Julie C Ribot
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649 028 Lisbon, Portugal
    J Immunol 192:2237-43. 2014
    ..These findings have implications for the manipulation of γδ T cells in cancer immunotherapy. ..
  61. pmc Conditional ablation of Tbr2 results in abnormal development of the olfactory bulbs and subventricular zone-rostral migratory stream
    Robert J Kahoud
    Division of Pediatric Critical Care Medicine, University of Washington and Seattle Children s Hospital, Seattle, Washington Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, Washington
    Dev Dyn 243:440-50. 2014
    ..Previous studies showed that Tbr2 is expressed during the generation of glutamatergic OB neurons in rodents...
  62. pmc Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells
    Aspen M Workman
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 9:e89010. 2014
    ..Thus, inflammatory signals induced by viral infection may overcome the need for strong IL-2 signals in driving cytotoxicity in CD4 cells...
  63. doi Establishment of bovine trophoblast stem-like cells from in vitro-produced blastocyst-stage embryos using two inhibitors
    Xianghua Huang
    1 The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, Hohhot, China
    Stem Cells Dev 23:1501-14. 2014
    ..The microarray analysis of bTS cells showed high expression levels of many TR markers, such as TEAD4, EOMES, GATA3, ETS2, TFAP2A, ELF5, SMARCA4 (BRG1), CDH3, MASH2, HSD17B1, CYP11A1, PPARG, ID2, GCM1, HAND1, TDK, PAG, IFN-..
  64. pmc Longitudinal requirement for CD4+ T cell help for adenovirus vector-elicited CD8+ T cell responses
    Nicholas M Provine
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215 and
    J Immunol 192:5214-25. 2014
    ....
  65. pmc T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection
    Marcus Buggert
    Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS Pathog 10:e1004251. 2014
    ..Two key transcription factors governing CD8(+) T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exhaustion in part through direct ..
  66. doi NK cell development in bone marrow and liver: site matters
    D Gotthardt
    Institute of Pharmacology and Toxicology, Department for Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
    Genes Immun 15:584-7. 2014
    ..The development of NK cells thus differs between the two organs. This needs to be considered when using NKp46 and DX5 as NK cell markers and when performing NK cell-specific gene deletion in Ncr1 transgenic mice. ..
  67. pmc A genomic duplication is associated with ectopic eomesodermin expression in the embryonic chicken comb and two duplex-comb phenotypes
    Ben Dorshorst
    Science for Life Laboratory, Dept of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden Dept of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS Genet 11:e1004947. 2015
    ..containing several conserved putative regulatory elements located 200 Kb upstream of the eomesodermin gene (EOMES). EOMES is a T-box transcription factor that is involved in mesoderm specification during gastrulation...
  68. pmc Development of the adult neurogenic niche in the hippocampus of mice
    Zeina Nicola
    Genomics of Regeneration, German Center for Neurodegenerative Diseases DZNE Dresden, and CRTD DFG Research Center for Regenerative Therapy, Technische Universit t Dresden Dresden, Germany
    Front Neuroanat 9:53. 2015
    ..We used markers most relevant to adult neurogenesis research to describe this transition: Nestin, Sox2, BLBP, GFAP, Tbr2, Doublecortin (DCX), NeuroD1 and Prox1...
  69. pmc Morphological and Gene Expression Changes in Cattle Embryos from Hatched Blastocyst to Early Gastrulation Stages after Transfer of In Vitro Produced Embryos
    Jessica van Leeuwen
    AgResearch Ruakura, Animal Productivity Section, Hamilton, New Zealand Department of Biological Sciences, University of Waikato, Hamilton, New Zealand
    PLoS ONE 10:e0129787. 2015
    ..involves the transition of the epiblast into the embryonic ectoderm with concomitant onset of posterior NODAL, EOMES and BRACHYURY expression...
  70. pmc Defining the three cell lineages of the human blastocyst by single-cell RNA-seq
    Paul Blakeley
    Human Embryology and Stem Cell Laboratory, The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK
    Development 142:3151-65. 2015
    ..Although the key trophectoderm factors Id2, Elf5 and Eomes are exclusively localized to this lineage in the mouse, the human orthologues are either absent or expressed in ..
  71. pmc Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development
    Ita Costello
    The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 29:2108-22. 2015
    ..The T-box transcription factor Eomes, acting downstream from Nodal/Smad signals, directly activates the LIM domain homeobox transcription factor Lhx1 ..
  72. pmc The evolution of basal progenitors in the developing non-mammalian brain
    Tadashi Nomura
    Developmental Neurobiology, Kyoto Prefectural University of Medicine, INAMORI Memorial Building, 1 5 Shimogamo Hangi cho, Sakyo ku, Kyoto 606 0823, Japan Japan Science and Technology Agency JST, PRESTO, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    Development 143:66-74. 2016
    ..In placental mammals, this proliferative cell population can be subdivided into several groups that include Tbr2(+) intermediate progenitors and basal radial glial cells (bRGs)...
  73. doi Evolutionary origin of Tbr2-expressing precursor cells and the subventricular zone in the developing cortex
    Veronica Martinez-Cerdeno
    Institute for Pediatric Regenerative Medicine, Shriners Hospital for Children of Northern California, Sacramento, California, 95817
    J Comp Neurol 524:Spc1. 2016
    ..Recent work in rodents has shown that Tbr2-expressing neural precursor cells in the SVZ produce excitatory neurons for each cortical layer in the neocortex...
  74. doi Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients
    Anastasia Dielmann
    Department of Medicine III Hematology, Oncology and Tumor Immunology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Cancer Immunol Immunother 65:181-92. 2016
    T-box transcription factors, T-box expressed in T cells (T-bet) encoded by Tbx21 and Eomesodermin (Eomes), drive the differentiation of effector/memory T cell lineages and NK cells...
  75. pmc Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity
    Stina L Urban
    Department of Pathology, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655, United States
    Virology 493:52-9. 2016
    ..distinguished by the upregulation of the surface activation marker CD69, effector-associated transcription factors Eomes and IRF4, and cytotoxicity effector molecule granzyme B...
  76. doi The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development
    Cecilia I Lopez
    Faculty of Medicine, Program in Physiology and Biophysics, Institute for Biomedical Sciences, Universidad de Chile, Santiago, Chile
    Dev Neurobiol 76:1360-1373. 2016
    ..observation that both the defects in neuronal migration and the increase in the number of cells expressing Sox2 and Tbr2 were associated to the knock-down of either CoREST or LSD1 and were reversed by the loss of Notch...
  77. pmc PAI-1 secretion of endometrial and endometriotic cells is Smad2/3- and ERK1/2-dependent and influences cell adhesion
    Cong Sui
    Center of Gynecology and Obstetrics, Faculty of Medicine, Justus Liebig University GiessenGermany Reproductive Medicine Center, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China
    Am J Transl Res 8:2394-402. 2016
    ..After binding of the ligands to the high-affinity receptors, TGF-β receptors (TBR1 and TBR2), TGF-βs activate Smad signaling to modulate gene expression and cellular functions...
  78. doi Diversity and function of group 1 innate lymphoid cells
    Victor S Cortez
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA
    Immunol Lett 179:19-24. 2016
    ..Group 1 ILCs produce IFN-γ, express the T-box transcription factors (TF) T-bet and/or Eomesodermin (Eomes), group 2 ILCs secrete IL-5 and IL-13 and express the TF GATA-3, while group 3 ILCs produce IL-22 and IL-17 and ..
  79. pmc mTOR Modulates Lymphocyte Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis in Rats
    Na Cui
    Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
    Chin Med J (Engl) 129:1704-10. 2016
    ..The role of mammalian target of rapamycin (mTOR), T-box expressed in T-cells (T-bet), and eomesodermin (EOMES) in mediating T lymphocytes differentiation in response to Aspergillus fumigatus infection in immunocompromised ..
  80. pmc Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes
    Caroline Stienne
    UMR INSERM, U1043, Toulouse 31300, France UMR CNRS, U5282, Toulouse 31300, France Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan CPTP, Toulouse 31300, France
    Immunity 45:774-787. 2016
    ..At the molecular level, we identified Eomes as a direct target gene for Foxo3 in CD4+ T cells and we have shown that lentiviral-based ..
  81. pmc Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals
    Johanna Tauriainen
    Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Sci Rep 7:40354. 2017
    ..cells were almost exclusively TIGIT+, had an inverse expression of the transcription factors T-bet and Eomes and co-expressed PD-1, CD160 and 2B4...
  82. pmc A simplified one-step nuclear transfer procedure alters the gene expression patterns and developmental potential of cloned porcine embryos
    Sang Kyu Park
    Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul 110 749, Korea
    J Vet Sci 15:73-80. 2014
    ..from both groups were cultured in vitro, the expression levels of developmentally important genes (OCT4, NANOG, EOMES, CDX2, GLUT-1, PolyA, and HSP70) were analyzed by real-time quantitative polymerase chain reaction...
  83. pmc Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients
    Shigehisa Kitano
    Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan Kettering Cancer Center, New York, NY 10065
    Cancer Immunol Res 1:235-44. 2013
    ..processed NY-ESO-1 protein in antigen-presenting cells, expressed master transcription factor Eomesodermin (Eomes) and secreted perforin and Granzyme B...
  84. pmc The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development
    Stefania Crotta
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Immunol 192:2677-88. 2014
    ..Our data identify E4BP4-independent NK cell developmental pathways and a role for E4BP4 in NK cell homeostasis. ..
  85. doi The differential effects of 2% oxygen preconditioning on the subsequent differentiation of mouse and human pluripotent stem cells
    Kate Fynes
    Department of Biochemical Engineering, The Advanced Centre for Biochemical Engineering, University College London, London, United Kingdom
    Stem Cells Dev 23:1910-22. 2014
    ..low oxygen was associated with a significant increase in the expression of early differentiation markers FGF5 and Eomes, while conversely we observed decreased expression of these genes in human PSCs...
  86. pmc Tbr2 is required to generate a neural circuit mediating the pupillary light reflex
    Neal T Sweeney
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064
    J Neurosci 34:5447-53. 2014
    ..Here, we show that the T-box transcription factor Tbr2 is required for the development of several RGC types that participate in non-image-forming circuits...
  87. doi Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos
    Pengfei Xu
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Mol Cell Biol 6:272-85. 2014
    ..Eomesa directly binds to the Eomes-binding sites in the promoter or enhancer of ndr1, ndr2, and mxtx2 to activate their transcription...
  88. ncbi Evolution of developmental functions by the Eomesodermin, T-brain-1, Tbx21 subfamily of T-box genes: insights from amphioxus
    Amy C Horton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    J Exp Zool 294:112-21. 2002
    ....
  89. ncbi Pallial origin of mitral cells in the olfactory bulbs of Xenopus
    Nerea Moreno
    Departmento de Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Neuroreport 14:2355-8. 2003
    We used two developmental transcription factors, x-Eomes (T-box family) and x-Lhx5 (LIM-homeodomain family), to follow the origin and development of the olfactory bulbs in Xenopus...
  90. doi Reversible effect of developmental exposure to chlorpyrifos on late-stage neurogenesis in the hippocampal dentate gyrus in mouse offspring
    Liyun Wang
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu shi, Tokyo 183 8509, Japan
    Reprod Toxicol 38:25-36. 2013
    ..There were no differences in the numbers of progenitor populations expressing Tbr2 or M1 muscarinic acetylcholine receptors...
  91. pmc MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain
    Tomasz Jan Nowakowski
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Proc Natl Acad Sci U S A 110:7056-61. 2013
    ..The generation of intermediate progenitors is regulated by the transcription factor Tbr2, whose expression marks these cells. We investigated how this mechanism might be controlled...
  92. pmc Differentiation of CD8 memory T cells depends on Foxo1
    Rodrigo Hess Michelini
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
    J Exp Med 210:1189-200. 2013
    ..normally enriched for memory-precursor cells retain Granzyme B and CD69 expression, and fail to up-regulate TCF7, EOMES, and other memory signature genes...
  93. pmc N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8+ T cell memory but not to effector differentiation
    Salvador Iborra
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, E 28049 Madrid, Spain
    J Exp Med 210:1463-79. 2013
    ..in vitro and in vivo of the antigen-mediated early induction of T-box transcription factor Eomesodermin (Eomes), whereas T-bet was unaffected...
  94. pmc CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development
    Kun Zhang
    Department of Veterinary and Animal Sciences, University of Massachusetts at Amherst, Amherst, MA 01003, USA
    Dev Biol 383:15-27. 2013
    ..Expression of some lineage specific factors is markedly reduced in Ctr9 knockdown embryos, including Eomes, Elf5 and Sox2, while others are inappropriately expressed (Oct4, Nanog, Gata6, Fgf4 and Sox17)...
  95. pmc Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes
    Jeong Hwan Yoon
    Department of Experimental Pathology, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan Department of Internal Medicine, Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Korea Department of Molecular Pathology, Tokyo Medical University, Tokyo, Japan Department of Microbiology, CHA University, Seoul, Korea
    EMBO Mol Med 5:1720-39. 2013
    ..We further identified eomesodermin (Eomes), the T-box transcription factor regulating CTL functions, as a specific target repressed by TGF-β via Smad4 and ..
  96. pmc Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity
    Nina Shah
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e76781. 2013
    ..Our findings introduce a clinically applicable strategy for the generation of highly functional CB-NK cells which can be used to eradicate MM. ..
  97. doi Distinctive population of Gfap-expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus
    Tatsunori Seki
    Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160 8402, Japan
    J Comp Neurol 522:Spc1. 2014
    ..GFP+ cells with Neurogenin2 expression were largely distributed in the VZ, whereas GFP+ cells with Tbr2 and NeuroD expressions were seen in the migratory stream and developing dentate gyrus...
  98. pmc Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development
    David A Cameron
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    BMC Neurosci 13:90. 2012
    ..To identify genes selectively expressed by the Eomes + (Tbr2) lineage of excitatory cortical neurons, GFP-expressing cells from Tg(Eomes::eGFP) Gsat embryos were ..
  99. doi Depletion of Suds3 reveals an essential role in early lineage specification
    Kun Zhang
    Department of Veterinary and Animal Sciences, University of Massachusetts at Amherst, 455, 661 N Pleasant Street, Amherst, MA 01003, USA
    Dev Biol 373:359-72. 2013
    ..Expression of essential lineage factors Nanog, Sox2, Cdx2, Eomes, Elf5 and Sox17 are severely reduced in the absence of Suds3...
  100. pmc Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes
    Michael A Paley
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Leukoc Biol 93:307-15. 2013
    The T-box transcription factor Eomes is expressed in cytotoxic immune cells and plays an important role in development, maintenance, and function of these cell types...
  101. pmc Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth
    Sabrina Malik
    Department of Pediatrics, Regional Neonatal Center, Maria Fareri Children s Hospital at Westchester Medical Center and New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 33:411-23. 2013
    ..We noted that both cycling and noncycling Sox2(+) radial glial cells and Tbr2(+) intermediate progenitors were abundant in human preterm infants until 28 gw...

Research Grants47

  1. Ming Li; Fiscal Year: 2014
    ..TGF-beta receptor II-deficient T cells are additionally associated with abnormal expression of Gfi-1, T-bet, and Eomes, transcription factors that regulate CD127 and CD122 expression...
  2. LAURA MARY MCLANE; Fiscal Year: 2014
    ..The transcription factors, Tbx21/T-bet and Tbr2/Eomes, have been implicated as critical regulators of CD8+ T-cell effector differentiation, including transcriptiona ..
  3. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Michael W Miller; Fiscal Year: 2010
    ..During their development, neural stem cells express a homeobox gene product(s), Pax6 and/or Tbr2. These proteins define the transition from (Pax6+) stem cells in the VZ to an (Tbr2+) intermediate progenitor cell ..
  4. CYTOTOXIC T LYMPHOCYTE ACTIVATION IN VITRO AND IN VIVO
    MATTHEW FRANKLIN MESCHER; Fiscal Year: 2013
    ..A number of transcription factors are regulated by IL-12/IFN1, including T-bet and eomesodermin (Eomes)...
  5. Arnob Banerjee; Fiscal Year: 2014
    ..to demonstrate that mice with T cells lacking the two highly homologous T-box transcription factors, Eomesodermin (Eomes) and T-bet, develop an inappropriate effector CD8+ T cell response to acute infection with lymphocytic ..
  6. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Frank A Middleton; Fiscal Year: 2013
    ..During their development, neural stem cells express a homeobox gene product(s), Pax6 and/or Tbr2. These proteins define the transition from (Pax6+) stem cells in the VZ to an (Tbr2+) intermediate progenitor cell ..
  7. MATTHEW EUGENE PIPKIN; Fiscal Year: 2015
    ....
  8. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013
    ..e., Krt12rtTA/rtTA/tet-O-Cre/Tbr2f/f and Krt12rtTA/rtTA/tet-O-Cre/Smad4f/f in which floxed Tbr2 and Smad4 genes are ablated specifically in corneal epithelium upon doxycycline induction so that one can determine ..
  9. Regulation of exhaustion and altered CD8 T cell memory during chronic Infection
    E John Wherry; Fiscal Year: 2010
    ..protective, memory CD8 T cells, and iii) investigate the role of two transcription factors, eomesodermin (eomes) and blimp-1, in controlling altered CD8 T cell differentiation and poor memory development during chronic ..
  10. Generation and Regulation of Anti-Viral CD4 T Cells with Cytolytic Potential
    Deborah M Brown; Fiscal Year: 2013
    ..In aim 2, candidate transcription factors such as STAT5, T-bet and Eomes, as well as unique transcription factors identified by microarray, will be tested for their ability to bind to the ..
  11. VEGF regulation of neurogenesis
    DIANE CATHERINE DARLAND; Fiscal Year: 2011
    ..As a consequence, the normal expression pattern of Tbr2-positive intermediate progenitor cells, critical for early cortical layer establishment, is disrupted...
  12. Regulation of conventional versus innate CD8+ T cell development
    Leslie J Berg; Fiscal Year: 2013
    ..This understanding will aid in efforts to regulate and control the immune system to fight infections and eradicate cancer cells. ..
  13. Steven L Reiner; Fiscal Year: 2015
    ..The specific aims of this project will address how and when Eomes functions in memory T cell programming...
  14. Sally Temple; Fiscal Year: 2015
    ..Moreover, the cell that receives Stau2 is typically a Tbr2+ intermediate progenitor (IPC) cell, the equivalent to the ganglion mother cell...
  15. Vassiliki A Boussiotis; Fiscal Year: 2016
    ..features of central memory-like cells characterized by increased expression of transcription factors TCF7 and EOMES and low levels of KLRG, all of which are regulated by Wnt signaling...
  16. STEPHANIE RENAE JACKSON; Fiscal Year: 2015
    ..T cell rescue corresponded with expression of the transcription factors T-bet and Eomesodermin (Eomes), both of which failed to be induced under tolerizing conditions in the absence of vaccination...
  17. Intermediate Progenitor Cells in Adult Hippocampal Neurogenesis
    Robert F Hevner; Fiscal Year: 2012
    ..Preliminary studies for this proposal suggest that Tbr2/Eomes (hereafter referred to simply as Tbr2), a T-domain transcription factor, is specifically expressed in the ..
  18. Molecular mechanisms regulating mitral cell development
    Fumiaki Imamura; Fiscal Year: 2012
    ..The candidate molecules are three transcription factors (Tbr1, Tbr2, Tbx21), an extracellular matrix molecule (Reelin), a transmembrane protein (Protocadherin21), and a synaptic ..
  19. Anthony T Vella; Fiscal Year: 2016
    ..This differentiation process requires IL-2, and the T-box transcription factor Eomesodermin (Eomes). The experimental plan will test if Eomes programs bone fide memory potential...
  20. Shannon A Carty; Fiscal Year: 2016
    ..of the activation/memory markers CD44 and CD122, expression of the T-box transcription factor Eomesodermin (Eomes) and ability to produce IFN[unreadable] rapidly after ex vivo stimulation...
  21. Michael R Betts; Fiscal Year: 2016
    ..CD8+ T effector cell and CD4+ T helper type-1 cell function,by the transcription factors T-bet and eomesodermin (eomes), in order to understand the failings of the HIV-specific T cell immune response during acute and chronic HIV ..
  22. Robert F Hevner; Fiscal Year: 2016
    ..The third Aim is to determine how Eomes, a transcription factor that is specifically expressed in INPs, regulates molecular and developmental properties ..
  23. Protul Shrikant; Fiscal Year: 2015
    ....
  24. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2007
    ..selectively unflox genes in fibroblasts whose functions are associated either with EMT or intercellular signaling (Tbr2 flox/flox , BMP4 flox/lacZ, cMet flox/flox, and Egfr flox/flox)...
  25. A Genetic Approach to Organogenesis in Xenopus
    Frank Conlon; Fiscal Year: 2006
    ..tropicalis. Two, determine the role of Shp-2 and Tbx5 in organ development through the generation of an allelic series of Shp-2 and Tbx5 in X. tropicalis. [unreadable] [unreadable]..
  26. Regulating TGF-beta signaling in neurodegeneration
    Amy Lin; Fiscal Year: 2003
    ..The distribution of TGF-beta type I (TBR1) and II (TBR2) receptors and the activation of Smad proteins will be examined in neurons in the presence and absence of ..
  27. Immune Regulation by Gadd45b and Gadd45g
    Binfeng Lu; Fiscal Year: 2010
    ..Relevance: This study will lead to the development of novel strategies targeting these molecules to treat or prevent autoimmune diseases. This study will also reveal new disease markers for autoimmune diseases. ..
  28. Regulation of the MAP kinase pathway in the CD4+ T cells
    Binfeng Lu; Fiscal Year: 2007
    ..Aim 2. Study the role of GADD45 protein in mediating the activation of the p38/JNK MAP kinase pathway by cytokines. Aim 3. Study the effect of mutation of GADD45gamma, GADD45beta, or MEKK4 in murine collagen induced arthritis. ..
  29. The Role of Eomesodermin in Cardiac Development
    Kenneth Ryan; Fiscal Year: 2007
    The role of Eomesodermin (Eomes), a T-box transcription factor, in cardiac development is incompletely understood...
  30. The role of p27kip1 in T-cell responses
    Vassiliki Boussiotis; Fiscal Year: 2003
    ....
  31. T LYMPHOCYTE ACTIVATION, DIFFERENTIATION AND DEATH
    Laurie Glimcher; Fiscal Year: 2002
    ..The Keystone Symposia has the advantage of allowing a large number of junior scientists and scientists in training to attend while being focused under a single theme, in this case T lymphocyte activation, signaling and death. ..
  32. THYMIC SELECTION AND T CELL LINEAGE COMMITMENT
    Leslie Berg; Fiscal Year: 2003
    ..This information could enhance our understanding of T cell recognition and the establishment of self-tolerance. ..
  33. GENE REGULATION IN T HELPER 1 CELLS
    Laurie Glimcher; Fiscal Year: 2004
    ..abstract_text> ..
  34. Mechanisms ot Maternal Immune Tolerence
    Laurie Glimcher; Fiscal Year: 2006
    ..abstract_text> ..
  35. TRANSCRIPTIONAL REGULATION OF THE IMMUNE RESPONSE
    LAURIE HOLLIS GLIMCHER; Fiscal Year: 2010
    ..4) Examine the role of XBP-1 in autoimmune disease.5) Investigate the requirement of XBP-1 for the development and propagation of plasma cell neoplasms. ..
  36. Expression and Function of Tob in T Lymphocytes
    Vassiliki Boussiotis; Fiscal Year: 2009
    ..abstract_text> ..
  37. The Role of Rap1 in T-Cell Responses
    Vassiliki Boussiotis; Fiscal Year: 2009
    ..Thus our in vitro and in vivo studies will complement each other in understanding the effects of Rap1 at the molecular/signaling level and in the intact host. ..
  38. TRANSCRIPTIONAL CONTROL OF HUMAN T CELL RECEPTOR GENES
    Laurie Glimcher; Fiscal Year: 2009
    ..abstract_text> ..
  39. Response to viral infection in immunodeficient mice
    Leslie Berg; Fiscal Year: 2007
    ..These studies will provide important information for future efforts to modulate T cell immune responses in vivo by manipulating distinct T cell signaling pathways. ..
  40. Arming the Immune System Against Pathogens
    Laurie Glimcher; Fiscal Year: 2007
    ..The overall objective of this interdependent, interdisciplinary team is to develop molecules that modulate the host immune system so as to augment the protective effects of vaccines against microbial pathogens. ..
  41. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  42. Immunobiology of Jak3 Deficient Mice
    Leslie J Berg; Fiscal Year: 2010
    ..Finally, we will determine the role of StatS as a downstream mediator of Jak-3 dependent cytokine signals in regulating effector T cell versus regulatory T cell differentiation pathways. ..
  43. FASEB Summer Research Conference: Lymphocytes/Antibodies
    Leslie Berg; Fiscal Year: 2002
    ..Immune Responses to Pathogens, Rafi Ahmed, Discussion Leader 7. Tolerance and Autoimmunity, Pam Ohashi, Discussion Leader 8. Innate Immunity, David Raulet, Dlscussion Leader 9. Dendritic Cells, Ken Shortman, Discussion Leader ..
  44. Tec family tyrosine kinases in T cell signaling
    Leslie Berg; Fiscal Year: 2009
    ..These studies will provide important information for future efforts to modulate Th1 vs. Th2 effector responses in vivo by manipulating distinct T cell signaling molecules and pathways. ..
  45. TRANSCRIPTION FACTOR NFATP IN CHONDROGENESIS
    Laurie Glimcher; Fiscal Year: 2004
    ....
  46. Tec Kinases ltk and RlK in Mast Cell Signaling
    Leslie Berg; Fiscal Year: 2009
    ..abstract_text> ..
  47. NIP45: A Novel Nuclear Protein that Regulates IL-4
    Laurie Glimcher; Fiscal Year: 2008
    ..abstract_text> ..