eNOS

Summary

Gene Symbol: eNOS
Description: nitric oxide synthase 3
Alias: ECNOS, eNOS, nitric oxide synthase, endothelial, EC-NOS, NOS type III, NOSIII, cNOS, constitutive NOS, endothelial NOS, nitric oxide synthase 3 (endothelial cell), nitric oxide synthase 3 transcript variant eNOS-delta20, nitric oxide synthase 3 transcript variant eNOS-delta20-21, nitric oxide synthase 3 transcript variant eNOS-delta21
Species: human

Top Publications

  1. ncbi The L-arginine-nitric oxide pathway
    S Moncada
    Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
    N Engl J Med 329:2002-12. 1993
  2. ncbi Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction
    Stefan Janssens
    Cardiology Division and Center for Transgene Technology and Gene Therapy, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Circ Res 94:1256-62. 2004
  3. ncbi AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults
    Marcelo Ferraz Sampaio
    Instituto Dante Pazzanese de Cardiologia, Sao Paulo, SP, Brazil
    Clin Chim Acta 377:154-62. 2007
  4. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
  5. ncbi Red blood cells express a functional endothelial nitric oxide synthase
    Petra Kleinbongard
    Department of Medicine, Medical Clinic I, University Hospital RTWH Aachen, Pauwelsstrasse 30 D 52074 Aachen, Germany
    Blood 107:2943-51. 2006
  6. pmc A systematic meta-analysis of genetic association studies for diabetic retinopathy
    Sotoodeh Abhary
    Department of Ophthalmology, Flinders Medical Centre and Flinders University, SA, Australia
    Diabetes 58:2137-47. 2009
  7. pmc Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
    You Yang Zhao
    Department of Pharmacology and 2Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois, USA
    J Clin Invest 119:2009-18. 2009
  8. ncbi A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
    M Yoshimura
    Division of Cardiology, Kumamoto University School of Medicine, Honjo, Japan
    Hum Genet 103:65-9. 1998
  9. ncbi Genetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males
    W H Lee
    Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Vasc Med 6:103-8. 2001
  10. ncbi The 27-bp tandem repeat polymorphism in intron 4 of the endothelial nitric oxide synthase gene is not associated with coronary artery disease in a hospital-based Taiwanese population
    Juey Jen Hwang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Cardiology 97:67-72. 2002

Research Grants

  1. Regulation of eNOS by the cell division cycle homolog, cdc37
    Michael Harris; Fiscal Year: 2006
  2. IGF-1, oxidative stress and telomere dynamics in cultured human somatic cells
    Rivka C Stone; Fiscal Year: 2012
  3. James M May; Fiscal Year: 2015
  4. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
  5. KLF2 as a regulator of endothelial cell biology
    MUKESH KUMAR JAIN; Fiscal Year: 2012
  6. Sanja Jelic; Fiscal Year: 2015
  7. KLF4 , the endothelium, and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2013
  8. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2012
  9. Adiponetin and AMPK Biosensor
    John Y J Shyy; Fiscal Year: 2010
  10. YVES CLAUDE GORIN; Fiscal Year: 2014

Detail Information

Publications369 found, 100 shown here

  1. ncbi The L-arginine-nitric oxide pathway
    S Moncada
    Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
    N Engl J Med 329:2002-12. 1993
  2. ncbi Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction
    Stefan Janssens
    Cardiology Division and Center for Transgene Technology and Gene Therapy, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Circ Res 94:1256-62. 2004
    ..Cardiomyocyte-restricted overexpression of NOS3 limits LV dysfunction and remodeling after MI, in part by decreasing myocyte hypertrophy in noninfarcted myocardium...
  3. ncbi AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults
    Marcelo Ferraz Sampaio
    Instituto Dante Pazzanese de Cardiologia, Sao Paulo, SP, Brazil
    Clin Chim Acta 377:154-62. 2007
    ..We investigated the relationship between NOS3, FGB and PAI-1 polymorphisms and endothelial dysfunction and risk factors for acute myocardial infarction (AMI) in young adults...
  4. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
    Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis...
  5. ncbi Red blood cells express a functional endothelial nitric oxide synthase
    Petra Kleinbongard
    Department of Medicine, Medical Clinic I, University Hospital RTWH Aachen, Pauwelsstrasse 30 D 52074 Aachen, Germany
    Blood 107:2943-51. 2006
    ..We now provide evidence that RBCs from humans express an active and functional endothelial-type NOS (eNOS), which is localized in the plasma membrane and the cytoplasm of RBCs...
  6. pmc A systematic meta-analysis of genetic association studies for diabetic retinopathy
    Sotoodeh Abhary
    Department of Ophthalmology, Flinders Medical Centre and Flinders University, SA, Australia
    Diabetes 58:2137-47. 2009
    ..A systematic meta-analysis was undertaken to collectively assess genetic studies and determine which previously investigated polymorphisms are associated with diabetic retinopathy...
  7. pmc Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
    You Yang Zhao
    Department of Pharmacology and 2Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois, USA
    J Clin Invest 119:2009-18. 2009
    ..Using mice with genetic deletions of caveolin 1 (Cav1) and eNOS (Nos3), we demonstrate here that chronic eNOS activation secondary to loss of caveolin-1 can lead to PH...
  8. ncbi A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
    M Yoshimura
    Division of Cardiology, Kumamoto University School of Medicine, Honjo, Japan
    Hum Genet 103:65-9. 1998
    ..been to elucidate the possible variants that occur in the coding region of the endothelial nitric oxide synthase (eNOS) gene and that may be associated with coronary spasm...
  9. ncbi Genetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males
    W H Lee
    Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Vasc Med 6:103-8. 2001
    ..with endothelial function and the development of coronary artery disease (CAD), endothelial nitric oxide synthase (ecNOS) gene a/b polymorphism and NADH/NADPH oxidase p22 phox gene C242T polymorphism were examined in 305 Korean male ..
  10. ncbi The 27-bp tandem repeat polymorphism in intron 4 of the endothelial nitric oxide synthase gene is not associated with coronary artery disease in a hospital-based Taiwanese population
    Juey Jen Hwang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Cardiology 97:67-72. 2002
    ..whether the 27 base pair (bp) tandem repeat polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene was associated with coronary artery disease (CAD) in a hospital-based Taiwanese population...
  11. ncbi Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans
    Rongling Li
    Department of Medicine, Clinical Research Center, Atlanta, Georgia, USA
    Am J Hypertens 17:560-7. 2004
    The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NOx) level, endothelial function, and blood pressure (BP) remains unclear.
  12. doi Endothelial nitric oxide gene polymorphisms, nitric oxide production and coronary artery disease risk in a South Indian population
    T Angeline
    PG and Research Department of Zoology and Biotechnology, Lady Doak College, Madurai 625 002, Tamil Nadu, India
    Exp Mol Pathol 89:205-8. 2010
    ..oxide (NO) synthesized by vascular endothelial cells, is a vasodilator agent produced from endothelial NO synthase (eNOS)...
  13. doi The endothelial nitric oxide synthase gene is associated with coronary artery disease: a meta-analysis
    Junyan Li
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    Cardiology 116:271-8. 2010
    Previous case-control studies have suggested that the endothelial nitric oxide synthase (eNOS) gene polymorphisms (G894T, 4b/a, T-786C) are associated with coronary artery disease (CAD)...
  14. doi Plasma total nitric oxide and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism: a study in a South Indian population
    Priya Gururajan
    Department of Biochemistry, International Centre for Cardiothoracic and Vascular Diseases, Dr K M Cherian Heart Foundation A Unit of Frontier LifeLine Pvt Ltd, R 30 C Ambattur Industrial Estate Road, Mogaippair, Chennai, India
    Biochem Genet 49:96-103. 2011
    In an analysis of the possible association of endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism and plasma nitric oxide levels in patients with acute coronary syndrome, we investigated 106 patients with the ..
  15. doi The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis
    Kui Zhang
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China
    Thromb Res 130:192-7. 2012
    Growing studies have revealed the underlying association between eNOS 894G/T (rs1799983) polymorphism and coronary heart disease (CHD) among Asia population. Results from these studies remained conflicting...
  16. doi Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus
    Parimala Narne
    Department of Genetics, Osmania University, Hyderabad, 500 007, India
    J Diabetes Complications 27:255-61. 2013
    The polymorphic variants of endothelial nitric oxide synthase (eNOS) gene have been implicated in endothelial dysfunction and are highly relevant to macroangiopathies...
  17. ncbi Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
    J P Gratton
    Department of Pharmacology and Program of Molecular Cardiobiology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 275:22268-72. 2000
    The activity of endothelial nitric-oxide synthase (eNOS) is regulated by its subcellular localization, phosphorylation and through its interaction with different proteins...
  18. ncbi Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
    Nicholas J Alp
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Arterioscler Thromb Vasc Biol 24:413-20. 2004
    Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a key signaling molecule in vascular homeostasis...
  19. ncbi Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis
    Igor Medica
    Division of Medical Genetics, Department of Gynecology and Obstetrics, University Clinical Centre, Ljubljana, Slovenia
    Eur J Obstet Gynecol Reprod Biol 131:115-26. 2007
    ..and report the results of a meta-analysis of polymorphisms investigated in more than five studies: Glu298Asp in eNOS gene (9 analyses involving 1055 patients and 1788 controls), Met235Thr in AGT gene (13 analyses involving 1128 ..
  20. doi Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression
    Mark J Crabtree
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Biol Chem 284:1136-44. 2009
    Tetrahydrobiopterin (BH4) is a critical determinant of endothelial nitric-oxide synthase (eNOS) activity. In the absence of BH4, eNOS becomes "uncoupled" and generates superoxide rather than NO...
  21. ncbi Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin
    J B Michel
    Cardiovascular Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:15583-6. 1997
    The endothelial nitric-oxide synthase (eNOS) is a key determinant of vascular homeostasis. Like all known nitric-oxide synthases, eNOS enzyme activity is dependent on Ca2+-calmodulin...
  22. doi Endothelial nitric oxide synthase Glu298Asp gene polymorphism in a multi-ethnical population with heart failure and controls
    Mônica Wanderley Monçores Velloso
    Fluminense Federal University, Pos Graduation Program of Cardiovascular Science, Niteroi, Brazil
    Nitric Oxide 22:220-5. 2010
    Brazilian population has a multi-ethnical profile and the prevalence of endothelial nitric oxide synthase enzyme (eNOS) polymorphism in heart failure (HF) has not been previously studied...
  23. ncbi Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
    G Garcia-Cardena
    Department of Pharmacology and the Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 271:27237-40. 1996
    The regulation of endothelial nitric oxide synthase (eNOS) by phosphorylation is poorly understood...
  24. ncbi The relationship between endothelial nitric oxide synthase gene polymorphism (T-786 C) and coronary artery disease in the Turkish population
    Burak Tangurek
    Cardiology Department, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey
    Heart Vessels 21:285-90. 2006
    Previous studies revealed that there were various mutations on endothelial nitric oxide synthase (eNOS) gene and these mutations might be a risk factor for coronary artery disease (CAD), myocardial infarction (MI), and hypertension (HT)...
  25. doi Is polymorphism within eNOS gene associated with the late onset of myocardial infarction? A pilot study
    Anna Gluba
    Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Poland
    Angiology 60:588-95. 2009
    Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a potent vasodilator...
  26. doi Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells
    Tatjana Brossette
    Institut fur Biochemie und Molekularbiologie I, Medizinische Fakultat, Heinrich Heine Universitat, P O Box 101007, 40001, Duesseldorf, Germany
    Eur J Nutr 50:595-9. 2011
    ..The dietary flavanol (-)-epicatechin has been suggested to mediate its vasodilatory effect by increasing nitric oxide levels in endothelial cells...
  27. doi Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population
    Thiago Magalhães da Silva
    Universidade Estadual de Santa Cruz, Department of Health, Laboratory of Pharmacogenomic and Genetic Epidemiology LAFEM, Ilheus, Bahia, 45662 900, Brazil
    Gene 502:142-6. 2012
    The present study aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG)...
  28. doi Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population
    Annan Sudarsan Arun Kumar
    Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Pondicherry, 605006, India
    Mol Biol Rep 40:1275-81. 2013
    ..05) but the odds ratio (0.6) did not show risk for MI. The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population...
  29. ncbi Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
    T O Fischmann
    Structural Chemistry Department, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Nat Struct Biol 6:233-42. 1999
    Crystal structures of human endothelial nitric oxide synthase (eNOS) and human inducible NOS (iNOS) catalytic domains were solved in complex with the arginine substrate and an inhibitor S-ethylisothiourea (SEITU), respectively...
  30. ncbi Relations between ACE gene and ecNOS gene polymorphisms and resistive index in type 2 diabetic patients with nephropathy
    H Taniwaki
    Second Department of Internal Medicine, Osaka City University Medical School, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Care 24:1653-60. 2001
    ACE and endothelial cell nitric oxide synthase (ecNOS) genotypes have been reported to be related to the incidence of renal diseases and coronary artery diseases...
  31. ncbi Lack of association between the Glu298Asp variant of the endothelial nitric oxide synthase gene and the risk of coronary artery disease among Taiwanese
    C L Wang
    First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 100:736-40. 2001
    Endothelial nitric oxide synthase (eNOS) plays a key role in atherosclerosis, because its product, nitric oxide, possesses antiatherogenic properties...
  32. ncbi Endothelial nitric oxide gene polymorphism (Glu298Asp) is not associated with coronary artery disease in Turkish population
    O Aras
    Thromb Haemost 87:347-9. 2002
  33. ncbi Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients
    N Cine
    Department of Genetics, Institute for Experimental Medical Research, University of Ystanbul, Turkey
    Clin Genet 61:66-70. 2002
    In this study we examined a possible association between a 27 base pair (bp)-repeat polymorphism in intron 4 of the ecNOS gene and myocardial infarction (MI) in a subgroup of the Turkish population...
  34. ncbi The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Am Coll Cardiol 41:930-7. 2003
    We investigated the association of polymorphisms in the promoter region and exon 7 endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD).
  35. ncbi The eNOS gene polymorphism does not have a major impact on lipid parameters and premature coronary artery disease in Caucasian women
    Mitja Letonja
    Department of Internal Medicine, General Hospital Ptuj, Slovenia
    Acta Cardiol 59:618-22. 2004
    Endothelial nitric oxide synthase (eNOS) catalyzes the formation of nitric oxide (NO) which has vasodilatory, antithrombotic, antiinflammatory and antiproliferative actions through which NO regulates blood pressure and modulates the ..
  36. ncbi eNOS gene intron 4 a/b VNTR polymorphism is a risk factor for coronary artery disease in Southern Turkey
    Selcuk Matyar
    Cukurova University, School of Medicine, Department of Biochemistry, 01330, Balcali, Adana, Turkey
    Clin Chim Acta 354:153-8. 2005
    ..The aim of this study was to investigate the role of endothelial nitric oxide synthase (eNOS) gene intron 4 a/b variable number of tandem repeats (VNTR) polymorphism and other risk factors in the development ..
  37. ncbi Endothelial nitric oxide synthase intron 4 polymorphism is a marker for coronary artery disease in African-American and Caucasian men
    Swapna Rao
    Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    Ethn Dis 15:191-7. 2005
    We investigated the association of the intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD).
  38. ncbi Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley 94710, USA
    Am J Med Genet A 138:21-6. 2005
    ..In particular, NPPA appears to be a good candidate gene for conotruncal defects and warrants further investigation...
  39. ncbi Interaction between -786TC polymorphism in the endothelial nitric oxide synthase gene and smoking for myocardial infarction in Korean population
    Inho Jo
    Department of Biomedical Sciences, National Institute of Health, 5 Nokbun dong, Eunpyung Gu, Seoul 122 701, South Korea
    Clin Chim Acta 365:86-92. 2006
    Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) mediates endothelium-dependent vasodilation and antithrombotic action...
  40. ncbi Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction
    Charalambos Antoniades
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 46:1101-9. 2005
    This study sought to evaluate the effect of genetic polymorphism G894T on endothelial nitric oxide synthase (eNOS); on the risk for myocardial infarction (MI); and on the release of von Willebrand factor (vWF), interleukin (IL)-6, IL-1b, ..
  41. ncbi Influence of endothelial nitric oxide synthase gene polymorphisms (-786T>C, 4a4b, 894G>T) in Korean patients with coronary artery disease
    In Jai Kim
    Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, 351 Yatap dong, Bundang gu, Seongnam, South Korea
    Thromb Res 119:579-85. 2007
    Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the eNOS3 gene on chromosome 7...
  42. ncbi Interaction among 5,10 methylenetetrahydrofolate reductase, plasminogen activator inhibitor and endothelial nitric oxide synthase gene polymorphisms predicts the severity of coronary artery disease in Turkish patients
    Deniz Agirbasli
    Department of Genetics, Marmara University Medical School, Istanbul, Turkey
    Coron Artery Dis 17:413-7. 2006
    ....
  43. ncbi Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with coronary artery disease in Iran
    Saeedeh Salimi
    Department of Biochemistry, School of Medicine, Shahid Rajaee Heart Hospital, Iran University of Medical Sciences, Tehran, Iran
    Indian J Med Res 124:683-8. 2006
    Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7...
  44. ncbi Association of endothelial nitric oxide synthase gene intron 4 polymorphism with end-stage renal disease
    Maria H Bellini
    Division of Nephrology and Geriatrics, Department of Medicine, Universidade Federal de Sao Paulo, and Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária IPEN CNEN SP, Sao Paulo, SP, Brazil
    Nephrology (Carlton) 12:289-93. 2007
    ..In the endothelial nitric oxide synthase (eNOS) intron 4 polymorphism, the presence of the aa genotype has been associated with cardiovascular and renal disease...
  45. pmc beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90
    Yong Ji
    Department of Clinical Pharmacology, Cardiovascular Division, School of Medicine, Center for Ultrastructural Imaging, King s College London, London SE1 9NH, United Kingdom
    Proc Natl Acad Sci U S A 104:8839-44. 2007
    ..These observations suggest that beta-actin plays a critical role in regulating NO formation and signaling in platelets...
  46. ncbi Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species
    Junhui Zhen
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Hypertens 21:28-34. 2008
    ..This study explored the effect of increased ROS activity on NOS expression in vitro in human coronary artery endothelial cells (HCAECs) grown in culture and in intact animals...
  47. doi Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension
    Azim Nejatizadeh
    Institute of Genomics and Integrative Biology, Delhi, India
    Free Radic Biol Med 44:1912-8. 2008
    ..This study identifies the NOS3 variants and haplotypes as genetic risk factors and as useful markers of increased susceptibility to the risk of essential hypertension...
  48. pmc Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction
    George K Andrikopoulos
    1st Cardiac Department, Evaggelismos Hospital, Athens, Greece
    BMC Med Genet 9:43. 2008
    This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital ..
  49. doi Association of coronary artery disease, erectile dysfunction, and endothelial nitric oxide synthase polymorphisms
    Jaroslav Meluzin
    First Department of Internal Medicine Cardioangiology, ICRC, St Anna Hospital, Masaryk University, Pekarska 53, Brno 65691, Czech Republic
    Heart Vessels 24:157-63. 2009
    ..dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for coronary angiography...
  50. doi The Glu298ASP polymorphism of the endothelial nitric oxide synthase gene is associated with premature ST elevation myocardial infarction in Mexican population
    Irma Isordia-Salas
    Instituto Mexicano del Seguro Social, Mexico DF, Mexico
    Clin Chim Acta 411:553-7. 2010
    The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial...
  51. doi Interaction between endothelial nitric oxide synthase gene polymorphisms (-786T>C, 894G>T and intron 4 a/b) and cardiovascular risk factors in acute coronary syndromes
    Jacqueline da Costa Escobar Piccoli
    Universidade Federal do Pampa, Campus Uruguaiana RS, Brazil
    Arch Med Res 43:205-11. 2012
    ..Polymorphisms in the NOS3 gene (eNOS) -786T>C, 894G>T and intron 4 a/b VNTR can be associated with a higher susceptibility for ACS...
  52. pmc Endothelial nitric oxide synthase (G894T) gene polymorphism in a random sample of the Egyptian population: comparison with myocardial infarction patients
    Mohamed Z Gad
    Clinical Biochemistry Unit, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Egypt
    Genet Test Mol Biomarkers 16:695-700. 2012
    The aim of this study was to detect endothelial nitric oxide synthase (eNOS) Glu298Asp gene variants in a random sample of the Egyptian population, compare it with those from other populations, and attempt to correlate these variants with ..
  53. pmc eNOS gene variants and the risk of premature myocardial infarction
    Aggeliki Maria Zigra
    Laboratory of Haematology and Blood Transfusion Unit, Attikon Hospital, School of Medicine, University of Athens, athina, Greece
    Dis Markers 34:431-6. 2013
    Endothelial nitric oxide synthase (eNOS) as well as nitric oxide play an important role in the regulation of cardiovascular function...
  54. doi Polymorphisms of the NOS3 gene and risk of myocardial infarction in the Tunisian population
    Amani Kallel
    Université de Tunis El Manar, Hopital La Rabta, Service de Biochimie, LR99ES11, 1007 Tunis, Tunisie
    Cytokine 64:646-51. 2013
    Controversial results regarding the association of eNOS gene (NOS3) polymorphisms with myocardial infarction (MI) have been reported...
  55. pmc Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme
    Chun An Chen
    Davis Heart and Lung Research Institute, Columbus, Ohio 43210, USA
    J Biol Chem 283:27038-47. 2008
    In the vasculature, nitric oxide (NO) is generated by endothelial NO synthase (eNOS) in a calcium/calmodulin-dependent reaction...
  56. ncbi Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants
    J E Tanus-Santos
    Division of Clinical Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Pharmacogenetics 11:719-25. 2001
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated inconsistently with cardiovascular diseases...
  57. ncbi A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility
    M Yoshimura
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Cardiol 85:710-4. 2000
    ..synthesis of nitric oxide (NO) from the amino acid L-arginine is catalyzed by the endothelial NO synthase (eNOS), and the continuously generated NO serves to maintain basal vascular tone...
  58. ncbi Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease
    A Hassan
    Department of Clinical Neurosciences, St George s Hospital Medical School, London, UK
    Stroke 35:654-9. 2004
    ..Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) is a key mediator of endothelial function...
  59. pmc Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation
    Ruth Fricker
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, D 69120 Heidelberg, Germany
    Br J Clin Pharmacol 58:169-77. 2004
    Polymorphisms of the NOSIII gene and of the CYBA gene have been associated with a number of pathological conditions such as arterial hypertension, coronary artery disease, and myocardial infarction...
  60. ncbi Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the -786T>C polymorphism
    Koji Abe
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pharmacogenet Genomics 15:329-36. 2005
    ..We examined endothelial nitric oxide synthase (eNOS) mRNA levels, mRNA stability and the transcriptional activities of the eNOS gene in human umbilical vein ..
  61. ncbi Genetic susceptibility to atrial fibrillation in patients with congestive heart failure
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
    Heart Rhythm 3:808-12. 2006
    Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS).
  62. ncbi eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite
    Sabrina Nagassaki
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Free Radic Biol Med 41:1044-9. 2006
    ..cholesterol synthesis and produce pleiotropic, cholesterol-independent effects including endothelial NO synthase (eNOS) stimulation and increased expression...
  63. doi Endothelial nitric oxide synthase polymorphisms are associated with hypertension and cardiovascular disease in renal transplantation
    Umanath Vasanth Bhandary
    Molecular Medicine Research Group and Department of Renal Medicine, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, University of Plymouth, Plymouth, UK
    Nephrology (Carlton) 13:348-55. 2008
    ..The aim was to determine the effect of NOS3 polymorphisms on hypertension and cardiovascular disease (CVD) in renal allograft recipients...
  64. doi Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population
    K T Moe
    Research and Development Unit, National Heart Centre, Singapore
    Eur J Neurol 15:1309-14. 2008
    ....
  65. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:971-9. 2010
    ..To evaluate the association between the nitric oxide synthase gene (NOS3) variants and primary open-angle glaucoma (POAG)...
  66. doi T-786C polymorphism in the endothelial nitric oxide synthase gene is associated with increased risk of coronary artery disease in a Chinese population
    Yi Han
    Department of Cardiology, School of Clinical Medicine, Southeast University, Nanjing, China
    Pharmacology 85:211-6. 2010
    ..The aim of this research was to discover whether the T-786C polymorphism in the promoter 5'-flanking region of the gene for endothelial nitric oxide synthase (eNOS) is associated with CAD.
  67. pmc A promoter polymorphism of the endothelial nitric oxide synthase gene is associated with reduced mRNA and protein expression in failing human myocardium
    Amit A Doshi
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Card Fail 16:314-9. 2010
    Alterations of endothelial nitric oxide synthase (eNOS) enzyme activity via eNOS gene polymorphisms have been associated with significant cardiovascular morbidity and mortality...
  68. doi Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise
    Carlos H G Sponton
    Laboratory of Research in Women s Health, Institute of Bioscience, University of Sao Paulo State, Rio Claro, SP, Brazil
    Eur J Cardiovasc Prev Rehabil 17:676-81. 2010
    The aim of this study was to investigate whether -786T>C endothelial nitric oxide synthase (eNOS) gene polymorphism might influence the effect of long-term exercise training (ET) on the blood pressure and its relationship with NO ..
  69. doi Endothelial nitric oxide synthase and angiotensinogen gene polymorphism in coronary artery diseases in Egypt
    Tarek Motawi
    Department of Biochemistry, Faculty of Pharmacy, Cairo University, Egypt
    Angiology 62:191-7. 2011
    ..We studied 100 patients with CAD and 50 healthy individuals to assess the association of endothelial nitric oxide (eNOS) polymorphism (Glu298Asp) and angiotensinogen polymorphisms (M235T) and CAD in an Egyptian population...
  70. ncbi Modifier effect of ENOS in autosomal dominant polycystic kidney disease
    A Persu
    Division of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
    Hum Mol Genet 11:229-41. 2002
    ..Thus, ENOS, the gene coding for the endothelial nitric oxide synthase (eNOS), could have a modifier effect in ADPKD...
  71. ncbi Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension
    Léon H G Henskens
    Department of Internal Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Stroke 36:1869-73. 2005
    ..Because these lesions may have a genetic background, we assessed the associations between polymorphisms of the renin-angiotensin system and the endothelial NO synthase (NOS3) genes and silent WMLs...
  72. doi Candidate genes and cerebral palsy: a population-based study
    Catherine S Gibson
    Schools of aPaediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    Pediatrics 122:1079-85. 2008
    ..The objective of this study was to examine whether selected genetic polymorphisms in the infant are associated with later-diagnosed cerebral palsy...
  73. ncbi Endothelial nitric oxide synthase (eNOS) Glu298-->Asp polymorphism (G894T) among south Indians
    N S Nishevitha
    PG and Research Department of Zoology and Biotechnology, Lady Doak College, Madurai, India
    Indian J Med Res 129:68-71. 2009
    ..It has been suggested that the single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (eNOS) (G894T) may affect the response of vascular endothelium to increased oxidative stress...
  74. ncbi An endothelial nitric oxide synthase gene polymorphism is associated with preeclampsia
    C B Tempfer
    Department of Obstetrics and Gynecology, Baylor College of Medicine, 6550 Fannin, Houston, Texas, USA
    Hypertens Pregnancy 20:107-18. 2001
    ..We sought to test the hypothesis that a polymorphism of the endothelial nitric oxide synthase gene (NOS3) is associated with preeclampsia...
  75. pmc Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis
    Christina K H Yu
    Harris Birthright Research Centre for Fetal Medicine, King s College, Hospital, Medical School, Denmark Hill, London, SE5 9RS, UK
    BMC Pregnancy Childbirth 6:7. 2006
    ..Recently, pre-eclampsia has been associated in some studies with carriage of a common eNOS gene Glu298Asp polymorphism, a variant that leads to the replacement of glutamic acid by aspartic acid at codon 298.
  76. pmc Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts
    Humaira Ayub
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 16:18-25. 2010
    To investigate the involvement of stress-regulating genes, endothelial nitric oxide synthase (eNOS) and heat shock protein 70 (HSP70) with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG).
  77. pmc A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice
    Pascal Bernatchez
    Providence Heart and Lung Institute, St Paul s Hospital, James Hogg Research Centre, 1081 Burrard St, Room 166, Vancouver BC Canada, V6Z 1Y6
    J Clin Invest 121:3747-55. 2011
    Aberrant regulation of eNOS and associated NO release are directly linked with various vascular diseases. Caveolin-1 (Cav-1), the main coat protein of caveolae, is highly expressed in endothelial cells...
  78. ncbi Influence of endothelial nitric oxide synthase gene polymorphisms (G894T, 4a4b, T-786C) and hyperhomocysteinemia on the predisposition to acute coronary syndromes
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, Section of Clinical Medicine and Cardiology, Thrombosis Centre, Azienda Ospedaliera Careggi, Florence, Italy
    Am Heart J 147:516-21. 2004
    ..In this study we investigated the role of endothelial nitric oxide synthase (eNOS) polymorphisms as predisposing factors to acute coronary syndromes (ACS).
  79. ncbi An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men
    Willem R P Agema
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Clin Sci (Lond) 107:255-61. 2004
    In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (..
  80. ncbi Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite
    Jian Xu
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Arterioscler Thromb Vasc Biol 26:2688-95. 2006
    ..of the present study is to determine whether hypochlorous acid (HOCl), the major oxidant of leukocyte-derived myeloperoxidase (MPO), oxidizes the zinc-thiolate center of endothelial nitric oxide synthase (eNOS) and uncouples the enzyme.
  81. ncbi Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias
    Tiago V Pereira
    Heart Institute InCor, Sao Paulo University Medical School, University of Sao Paulo, Brazil
    J Hypertens 25:1763-74. 2007
    ..To explore this hypothesis further, we performed a meta-analysis and re-evaluated the relationship between the three most widely studied NOS3 polymorphisms and hypertension status and blood pressure levels...
  82. pmc Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children
    M T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Allergy 66:412-9. 2011
    ..The aims of the study were to evaluate the role of genetic variations in nitric oxide synthases and arginases on FeNO in children and to assess the influence of asthma and respiratory allergy on these genetic associations...
  83. ncbi Expression of an endothelial-type nitric oxide synthase isoform in human neutrophils: modification by tumor necrosis factor-alpha and during acute myocardial infarction
    - de Frutos
    Cardiovascular Research and Hypertension Laboratory, Fundacion Jimenez Diaz, Madrid, Spain
    J Am Coll Cardiol 37:800-7. 2001
    The purpose of this study was to determine whether human neutrophils express an endothelial-type nitric oxide synthase (eNOS), and to study the effect of tumor necrosis factor-alpha (TNF-alpha) on its expression.
  84. pmc Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults
    Iftikhar J Kullo
    Divisions of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Atherosclerosis 196:905-12. 2008
    ..These findings motivate further investigation of the role of NOS3 variants in determining susceptibility to peripheral arterial disease...
  85. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arch Ophthalmol 129:773-80. 2011
    ..To evaluate whether an association between risk of any of the factors of hypertension, alcohol intake, and cigarette smoking and the risk of primary open-angle glaucoma (POAG) depended on nitric oxide synthase 3 (NOS3) gene variants...
  86. ncbi Endothelial nitric oxide synthase gene polymorphism and maternal vascular adaptation to pregnancy
    M D Savvidou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Hypertension 38:1289-93. 2001
    ..They also provide a potential mechanism linking the endothelial NO synthase polymorphism with the development of cardiovascular disorders and have implications for understanding the genetic basis of preeclampsia...
  87. doi Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy
    Pardeep Kumar Aggarwal
    Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Hypertens Res 33:473-7. 2010
    ..The complexity of interaction between these genetic abnormalities requires further studies...
  88. ncbi Prevalence of eNOS Glu298Asp polymorphism in healthy volunteers from a region of Northern India
    Kamna Srivastava
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Community Genet 8:180-3. 2005
    Endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphisms are under extensive study worldwide due to their suggested role in cardiovascular disorders...
  89. ncbi Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222 Larissa, Greece
    Hypertension 48:700-10. 2006
    ..In conclusion, there is evidence of association only between 4b/a polymorphism and hypertension; however, studies exploring combinations of the polymorphisms may help us better understand the genetics of hypertension...
  90. pmc Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression
    Margaret E McCormick
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Arterioscler Thromb Vasc Biol 31:643-9. 2011
    NO produced by the endothelial NO synthase (eNOS) is an important regulator of cardiovascular physiological and pathological features. eNOS is activated by numerous stimuli, and its activity is tightly regulated...
  91. doi Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of venous thromboembolism in Chinese population
    Yan Yan Li
    Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Institute of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, China
    Thromb Res 127:324-7. 2011
    Endothelium derived nitric oxide (NO) is a key mediator of vascular homeostasis. Endothelial nitric oxide synthase (eNOS) gene, by affecting the expression and functional activity of the eNOS enzyme, thereby reducing NO availability, may ..
  92. ncbi Association of a missense Glu298Asp mutation of the endothelial nitric oxide synthase gene with end stage renal disease
    H Suzuki
    Division of Nephrology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Clin Chem 46:1858-60. 2000
  93. ncbi Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase
    M P Schneider
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Germany
    J Hypertens 18:1767-73. 2000
    To test whether the Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene is of functional relevance in humans by altering endothelium-dependent vasodilation.
  94. ncbi Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathway
    Johanna Weiss
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    High Alt Med Biol 4:355-66. 2003
    ..The results of this study suggest that none of these genetic variants plays a substantial role in the pathogenesis of HAPE in Caucasians, but does not exclude epistatic effects that might still involve the genetic systems studied here...
  95. ncbi eNOS T-786C genotype, physical activity, and peak forearm blood flow in females
    Sheri A Data
    Department of Kinesiology, University of Maryland, College Park 20742 2611, USA
    Med Sci Sports Exerc 35:1991-7. 2003
    The purpose of the present study was to determine interactive and main effects of the eNOS T-786C gene polymorphism and habitual physical activity level on forearm vascular resistance (FVR) and forearm blood flow (FBF) at rest and during ..
  96. ncbi The 894 G > T variant of endothelial nitric oxide synthase (eNOS) increases the risk of recurrent venous thrombosis through interaction with elevated homocysteine levels
    S G Heil
    Department of Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Thromb Haemost 2:750-3. 2004
    ..Recently, the 894 G > T variant of endothelial nitric oxide synthase (eNOS) was postulated to be associated with hyperhomocysteinemia.
  97. ncbi Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics
    Krishna Yanamandra
    Department of Pediatrics, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Biochem Biophys Res Commun 335:545-9. 2005
    The purpose of the present study was to investigate an association of the endothelial nitric oxide synthase (eNOS) gene polymorphism with asthma...
  98. ncbi Susceptible and protective eNOS haplotypes in hypertensive black and white subjects
    Valeria Cristina Sandrim
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Atherosclerosis 186:428-32. 2006
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with hypertension...
  99. ncbi Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 13:826-31. 2006
    Polymorphisms of endothelial nitric oxide synthase (eNOS) gene in the promoter (T-786C) and exon 7 (G894T) have been suggested to attenuate endothelial function...
  100. ncbi Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy
    Anna Möllsten
    Department of Clinical Sciences, Umea University, Umea, Sweden
    Ann Med 38:522-8. 2006
    ..We therefore studied association between DN and two polymorphisms in NOS3, Glu298Asp and NOS4ab, in Caucasian type 1 diabetes (T1D) patients...
  101. doi The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels
    Akiko Imamura
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Endocrinol 158:189-95. 2008
    Genetic variants of the endothelial nitric oxide synthase (eNOS) gene, Glu298Asp and T-786C, have been reported to be associated with cardiovascular disease...

Research Grants75

  1. Regulation of eNOS by the cell division cycle homolog, cdc37
    Michael Harris; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Endothelial nitric oxide synthase (eNOS) via the production of nitric oxide (NO) in the vascular endothelium plays a key role in cardiovascular biology...
  2. IGF-1, oxidative stress and telomere dynamics in cultured human somatic cells
    Rivka C Stone; Fiscal Year: 2012
    ..However, in the human vascular endothelium, the effect of IGF-1 is tilted towards endothelial NOS (eNOS)...
  3. James M May; Fiscal Year: 2015
    ..Key to his aim is to assess whether diabetes-induced oxidative stress and subsequent endothelial dysfunction is worsened by depletion of ascorbic acid and reversed by its repletion. ..
  4. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..Activation of NADPH oxidase and uncoupled activity of endothelial nitric oxide synthase (eNOS) are sources of superoxide (O2[unreadable]-) in the pulmonary arteries in PPHN...
  5. KLF2 as a regulator of endothelial cell biology
    MUKESH KUMAR JAIN; Fiscal Year: 2012
    ..anti-inflammatory and anti-thrombotic factors such as thrombomodulin (TM) and endothelial nitric oxide synthase (eNOS)...
  6. Sanja Jelic; Fiscal Year: 2015
    ....
  7. KLF4 , the endothelium, and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..TF) and (2) KLF4 induces the expression of flow-regulated factors such as endothelial nitric oxide synthase (eNOS) and thrombomodulin (TM)...
  8. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2012
    ..Aim 2 will define the impact of PPARg activation on post- translational mechanisms regulating eNOS activity in vitro and in vivo...
  9. Adiponetin and AMPK Biosensor
    John Y J Shyy; Fiscal Year: 2010
    ..receptors elicits AMP-activated protein kinase (AMPK) to phosphorylate/activate endothelial nitric oxide synthase (eNOS), which enhances NO bioavailability...
  10. YVES CLAUDE GORIN; Fiscal Year: 2014
    ..A major defense of endothelial cells against vascular injury is endothelial nitric oxide synthase (eNOS), which generates nitric oxide (NO) in the presence of optimal concentrations of the substrate L-arginine and the ..
  11. Jianxin Sun; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is critical to the maintenance of vascular homeostasis through promoting vasodilation and inhibiting vascular smooth muscle ..
  12. BRADLEY MARON; Fiscal Year: 2016
    ..We will use two different models of PAH in rats in vivo and LC-MS to identify ETB cysteinyl thiol oxidation product(s). These studies aim to identify novel treatment targets for PAH and other vascular diseases with similar pathobiology. ..
  13. Stephen M Black; Fiscal Year: 2016
    The overall goal of these continuing studies is to understand how endothelial nitric oxide synthase (eNOS) signaling is regulated in the pulmonary system with emphasis on its role in the perinatal period...
  14. Purinergic signaling in sleep apnea
    Elzbieta Kaczmarek; Fiscal Year: 2012
    ..reactive oxygen species (ROS), inflammation, and impairment of the activity of endothelial nitric oxide synthase (eNOS), an enzyme responsible for generation of nitric oxide, whose bioavailability is key for proper function of the ..
  15. Biological Mechanisms of Vascular Dysfunction with Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2013
    ..is to determine the role of tetrahydrobiopterin (BH4;an essential cofactor for endothelial nitric oxide synthase (eNOS) and nitric oxide [NO] synthesis) and eNOS uncoupling as potential mediators of oxidative stress-related ..
  16. Richard C Venema; Fiscal Year: 2015
    ..in endothelial cells by oxidation of arginine catalyzed by the enzyme, endothelial nitric oxide synthase (eNOS)...
  17. Shear stress, SIRT1, and Arterial Stiffening
    JOHN Y_J SHYY; Fiscal Year: 2013
    ..As a consequence of the activated CaMKKb-SIRT1 pathway, the endothelial nitric oxide synthase (eNOS)-derived NO bioavailability and PGC-1a-regulated ROS scavenger expression are augmented...
  18. Richard B Silverman; Fiscal Year: 2016
    ..these compounds while increasing their potency and selectivity for nNOS over the other two isoforms of NOS, endothelial NOS (eNOS) and inducible NOS (iNOS) to minimize side effects and toxicities...
  19. Sumathy Mohan; Fiscal Year: 2015
    ..The knowledge gained will help to identify new avenues that will improve the current treatment modalities aimed to prevent or minimize the severity of vascular complications of IDDM patients. ..
  20. Mechanisms and Regulation of Inducible Nitric Oxide Synthase
    JOSEPH EDWARD SABAT; Fiscal Year: 2010
    ..There are several known physiological functions of NO generated by iNOS and its two constitutive isofrms (nNOS and eNOS) including regulation of vascular tone, neurotransmission, cell signaling, and combating infection...
  21. Christie P Thomas; Fiscal Year: 2014
    ..We hypothesize that sFlt1 inhibits glomerular endothelial nitric oxide synthase (eNOS) and NO release which in turn increases ET-1 expression and release from GEC...
  22. Bingmei M Fu; Fiscal Year: 2014
    ..c) after pretreatment with the blocking antibodies to tumor cell adhesion molecules and d) after pretreatment with eNOS inhibitors to microvessel endothelial cells;2) use filter-based adhesion/transmigration assays to determine the ..
  23. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..Nitric oxide (NO) from endothelium nitric oxide synthase (eNOS) is important in maintaining normal cerebral blood flow...
  24. Wai Hong Wilson Tang; Fiscal Year: 2016
    ..Our studies have identified loss of pulmonary vascular endothelial nitric oxide synthase (eNOS) activity in PAH, and that the NO deficiency leads to hypoxia-inducible factor-1 (HIF-1) activation, which results ..
  25. Sonia M Najjar; Fiscal Year: 2016
    ..of CEACAM1 by both insulin and VEGF receptors regulates Akt1 activation of endothelial Nitric Oxide Synthase (eNOS), an essential step in mediating endothelial function, it is reasonable to propose that CEACAM1 is the shared ..
  26. Jeffrey S Isenberg; Fiscal Year: 2014
    ..that TSP1, in binding to its necessary receptor CD47, inhibits activation of endothelial nitric oxide synthase (eNOS) and thus endothelial NO production, and that TSP1 and CD47 are dramatically upregulated in human and experimental ..
  27. JOY N JONES BUIE; Fiscal Year: 2014
    ..of VED are multifactorial, all pathways converge on the diminished activity of endothelial nitric oxide synthase (eNOS) expression and loss of NO bioavailability important for blood vessel protection...
  28. ADAM CARL STRAUB; Fiscal Year: 2015
    ..At the MEJ, endothelial nitric oxide synthase (eNOS), and the denitrosylase S-nitrosoglutathione reductase (GSNOR), work in concert to modulate the permeability of GJs...
  29. Chieko Mineo; Fiscal Year: 2014
    ..completed studies indicate that aPL isolated from APS patients fully antagonize endothelial nitric oxide synthase (eNOS) through impaired phosphorylation of the enzyme at S1177 via the phosphatase PP2A...
  30. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2012
    ..At the MEJ, endothelial nitric oxide synthase (eNOS), and the denitrosylase S-nitrosoglutathione reductase (GSNOR), work in concert to modulate the permeability of GJs...
  31. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2009
    ..We believe this research plan uniquely examines plausible biological mechanisms to better understand the mortality risk which threatens susceptible elderly populations during episodes of poor air quality. ..
  32. Avtar K Singh; Fiscal Year: 2015
    ..AMPK), which in turn may up regulate the superoxide-producing activity of endothelial nitric oxide synthase (eNOS), and thus maintains a vicious cycle of neuroinflammatory secondary injury...
  33. eNOS-actin Interaction and Oxygen in Lung Endothelium
    Yunchao Su; Fiscal Year: 2012
    Endothelial nitric oxide synthase (eNOS) is tightly regulated by a variety of transcriptional, posttranscriptional, and posttranslational mechanisms...
  34. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard H Karas; Fiscal Year: 2012
    ..EC) involves rapid activation of the kinase Akt, and subsequent activation of endothelial nitric oxide synthase (eNOS). eNOS protein abundance is also transcriptionally regulated by ERs...
  35. Ming Hui Zou; Fiscal Year: 2016
    ..found that reactive nitrogen species such as peroxynitrite (ONOO-) uncouples endothelial nitric oxide synthase (eNOS) {generates superoxide anions (O2...
  36. Mechanosensitivity of Cell Membranes: Role of Lipid-Protein Interactions
    Mirianas Chachisvilis; Fiscal Year: 2012
    ..link to function of membrane-associated proteins such as GPCRs, G-proteins and endothelial nitric oxide synthase (eNOS), and can mediate mechanochemical signal transduction, and (3) what are the specific mechanisms leading to ..
  37. Mechanisms of NAMPT-stimulated nitric oxide release at the myoendothelial junctio
    ADAM CARL STRAUB; Fiscal Year: 2010
    ..Additionally, numerous reports have demonstrated that caveolae regulate endothelial nitric oxide synthase (eNOS) transport and activity...
  38. HUA LINDA CAI; Fiscal Year: 2016
    ABSTRACT The central focus of this application is to address three hypotheses: 1) NAD(P)H oxidase 1 (NOX1) mediates eNOS uncoupling in diabetes;2) Folic acid (FA)-dependent restoration of eNOS cofactor tetrahydrobiopterin (H4B) salvage ..
  39. microRNA regulation of endothelial functions
    William C Sessa; Fiscal Year: 2013
    ..we have identified a specific miRNA (miR-155) that regulates the levels of endothelial nitric oxide synthase (eNOS) in cultured EC...
  40. Maternal Uterine Vascular Origins of Fetal Alcohol Spectrum Disorders
    Jayanth Ramadoss; Fiscal Year: 2013
    ..are controlled by endothelial-derived nitric oxide (NO) and enzyme activity of endothelial nitric oxide synthase (eNOS)...
  41. Zvonimir S Katusic; Fiscal Year: 2016
    ..Pharmacological or genetic inactivation of endothelial nitric oxide synthase (eNOS) causes up-regulation of APP and BACE1, leading to increased production of A[unreadable]...
  42. The Role of Human Cytomegalovirus in Vascular Pathogenesis
    Sarah Welsh; Fiscal Year: 2012
    ..It is believed that human cytomegalovirus (HCMV) plays a role in vascular diseases such as atherosclerosis. Because the virus affects between 60-90% of the U.S. population it is important to determine how HCMV causes vascular disease. ..
  43. REBECCA LUCY HULL-MEICHLE; Fiscal Year: 2014
    ..is sufficient to cause impaired insulin release in transgenic mice that lack endothelial nitric oxide synthase (eNOS) and develop endothelial dysfunction...
  44. Generating Mouse Mutants with Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2010
    ..Genetic disruption of endothelial nitric oxide synthase (eNOS or NOSIII), but not ApoE or LDLR was associated with a marked acceleration of DN in C57BL/6, not only characterized by a ..
  45. Ethan P Marin; Fiscal Year: 2014
    ..The environment and the proposed project provide excellent opportunity for the PI to develop a successful independent career as an academic physician-scientist. ..
  46. Mechanism of Vascular Remodeling in Hyperhomocysteinemia
    Suresh C Tyagi; Fiscal Year: 2010
    ..causing thickening (fibrosis) of the basement membrane, rendering ineffective endothelial nitric oxide synthase (eNOS) and promotes endothelial-smooth muscle disconnection/uncoupling by antagonizing PPARy activity...
  47. Redox Regulation of Endothelial Nitric Oxide Synthase and Cardiovascular Diseases
    Chun An Chen; Fiscal Year: 2011
    ..In the endothelium, endothelial nitric oxide synthase (eNOS) is the important enzyme that produces this critical molecule maintaining the cardiovascular function...
  48. Jeffrey A Kline; Fiscal Year: 2015
    ..lung NO biosynthesis through the release of arginase-1, which depletes the endothelial nitric oxide synthase (eNOS) substrate, L-arginine...
  49. Angiotensin-II, GTPCH1 and 26S Protesomes
    Ming Hui Zou; Fiscal Year: 2013
    ..Several recent studies suggest that BH4 deficiency is responsible for endothelial nitric oxide synthase (eNOS) uncoupling during hypertension, as seen by the finding that hypertension and related eNOS uncoupling are ..
  50. Mechanisms of Vascular Dysfunction in Diet-Induced Obesity
    Sean P Didion; Fiscal Year: 2013
    ..Results from these studies should provide new insight into mechanisms related to oxidative stress and vascular dysfunction in response to a diet high in fat and are aimed at improving public health. ..
  51. Chun An Chen; Fiscal Year: 2014
    ..In the endothelium, endothelial nitric oxide synthase (eNOS) is the important enzyme that produces this critical molecule maintaining the cardiovascular function...
  52. Pharmacogenetics of Pediatric Sickle Cell Disease
    Kathleen A Neville; Fiscal Year: 2010
    ..aims will test the following hypotheses: (1) that genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene affect nitric oxide availability and the pathogenesis of vaso-occlusive crisis, and (2) that genetic variants ..
  53. Joseph H Sisson; Fiscal Year: 2016
    ..cilia? We explore this question in Aim #1 by examining the role alcohol plays in activating nitric oxide synthase (eNOS) by enhancing the chaperone function of eNOS by heat shock protein 90 (HSP90)...
  54. Structural/Functional Modularity in Nitric Oxide Synthase
    Linda J Roman; Fiscal Year: 2012
    ..For example, sequence inserts in the constitutive NOS enzymes (nNOS and eNOS) confer regulatory properties that do not exist in the inducible isoform (iNOS)...
  55. Thomas L Pallone; Fiscal Year: 2014
    ..is heavily regulated by NO and heme oxygenase (HO) and that it is modified in Dahl salt sensitive rats and eNOS null mice...
  56. Redox regulation of endothelial function and wound healing
    Alex F Chen; Fiscal Year: 2010
    ..of three endothelial factors on wound healing - tetrahydrobiopterin (BH4) and endothelial nitric oxide synthase (eNOS), endothelial morphogen sonic hedgehog (SHH), and endothelial progenitor cells (EPCs)...
  57. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..CST transiently stimulates gluconeogenesis by attenuating endothelial nitric oxide synthase (eNOS) and 5'-adenosine monophosphate-activated protein kinase (AMPK), and enhances glucose disposal and glycogen ..
  58. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2012
    ..VEGF stimulates angiogenesis through upregulation of endothelial nitric oxide synthase (eNOS), which increases nitric oxide (NO) production...
  59. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2012
    ..Proteasome inhibitors enhance endothelial nitric oxide synthase (eNOS) expression and improve endothelial function...
  60. Matthew J Campen; Fiscal Year: 2016
    ..Results from these studies will assist in the assessment and management of personal risk of health effects from air pollution exposure. ..
  61. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009
    ..the cellular response is associated with intense nitrotyrosine (NY) staining, indicating that NO derived from eNOS and/or iNOS is inactivated by insufficiently scavenged O2 to form the RNS, peroxynitrite (ONOO)...
  62. David A Ford; Fiscal Year: 2014
    ..Mechanisms responsible for chlorinated lipid mediated eNOS dysfunction will be examined...
  63. John A Auchampach; Fiscal Year: 2016
    ..NOS isoforms (eNOS, nNOS or iNOS) and their signaling pathways activated by the EETs will be identified...
  64. Neuron-Dervied S1P and Endothelial Function in Stroke
    Christian Waeber; Fiscal Year: 2010
    ..In brain EC, sphingosine-1-phosphate (S1P) induces Akt/endothelial nitric oxide synthase (eNOS) activation, suppresses apoptosis and induces proliferation...
  65. Zheng Gen Jin; Fiscal Year: 2015
    ..to endothelium and the improvement of endothelial dysfunction through enhancing endothelial nitric oxide synthase (eNOS) expression and activity...
  66. Matthias L Riess; Fiscal Year: 2014
    ..yet unknown if SS can respond to IPC and if resistance to IPC is related to differences in endothelial NO synthase (eNOS) activity possibly modulated by the DNA-binding protein inhibitor Id2 and the peroxisome proliferator-activated ..
  67. Statins To Prevent Progression of Glaucoma: The STOP Glaucoma Trial
    Joshua D Stein; Fiscal Year: 2013
    ....
  68. HSV Amplicon Vectors for Cerebral Ischemia
    Ennio Chiocca; Fiscal Year: 2004
    ..intra-arterially administered HSV amplicon vector for the delivery of the murine endothelial nitric oxide synthase (eNOS) cDNA into the cerebral endothelial cells of mice exposed to an ischemic insult...
  69. NITRIC OXIDE SYNTHASE ISOFORMS IN ATHEROSCLEROSIS
    Paul Huang; Fiscal Year: 2006
    In the previous funding period, we used eNOS and iNOS knockout mice to demonstrate that physiologic production of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) suppresses atherosclerosis, whereas pathologic production of ..
  70. NOS1/NOS3 Functional Effects on Cardiac Myocyte Function
    Mark T Ziolo; Fiscal Year: 2010
    ..express enzymes termed neuronal nitric oxide synthase (nNOS, NOS1) and endothelial nitric oxide synthase (eNOS, NOS3)...
  71. FUNCTIONAL DOMAINS IN ENDOTHELIAL NITRIC OXIDE SYNTHASE
    RICHARD VENEMA; Fiscal Year: 2000
    DESCRIPTION: Endothelial nitric oxide synthase (eNOS) plays an important role in the regulation of vascular tone and platelet aggregation...
  72. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    ..The upregulation of eNOS directly contributes to the fall in TPR which is not confined to the placenta...
  73. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..Our laboratory is interested in the role of endogenously derived nitric oxide (NO) from eNOS (endothelial derived nitric oxide synthase), endothelin-1 (ET-1), and the effect of hypoxia on the development of ..
  74. NITRIC OXIDE/SUPEROXIDE IN LIPID VASCULAR DISEASE
    TIMOTHY O BRIEN; Fiscal Year: 2000
    ..NO is generated in the endothelium by eNOS and can be inactivated with superoxide anions. Superoxide anions are scavenged by SOD...
  75. Hsp90, NOS3 and Cardioprotection
    Yang Shi; Fiscal Year: 2009
    ..abstract_text> ..