ENAH

Summary

Gene Symbol: ENAH
Description: enabled homolog (Drosophila)
Alias: ENA, MENA, NDPP1, protein enabled homolog, mammalian enabled variant 11a, mammalian enabled variant pan
Species: human

Top Publications

  1. pmc Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes
    Theis Stüven
    ZMBH, INF 282, D 69120 Heidelberg and Universität Lübeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    EMBO J 22:5928-40. 2003
  2. ncbi NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation
    Noriko Hirao
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
    FEBS Lett 580:6464-70. 2006
  3. pmc A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family
    K Niebuhr
    Abteilung Zellbiologie und Immunologie AG Molekulare Erkennung, Mascheroder Weg 1, 38124 Braunschweig, Germany
    EMBO J 16:5433-44. 1997
  4. ncbi Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
    S Krugmann
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 11:1645-55. 2001
  5. ncbi TES is a novel focal adhesion protein with a role in cell spreading
    Amanda S Coutts
    Cancer Research UK Laboratories, Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    J Cell Sci 116:897-906. 2003
  6. ncbi Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase
    Katsuko Tani
    School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Biol Chem 278:21685-92. 2003
  7. pmc The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions
    Boyan K Garvalov
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    J Cell Biol 161:33-9. 2003
  8. ncbi Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system
    Torsten Giesemann
    Cell Biology, Zoological Institute, Technical University of Braunschweig, D 38092 Braunschweig, Germany
    J Neurosci 23:8330-9. 2003
  9. ncbi Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
    Matthias Krause
    Department of Biology and Center for Cancer Research, MIT, Cambridge, MA 02139, USA
    Dev Cell 7:571-83. 2004
  10. ncbi RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
    Esther M Lafuente
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 7:585-95. 2004

Research Grants

  1. Michelle L Gumz; Fiscal Year: 2014
  2. Mary C Beckerle; Fiscal Year: 2015
  3. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2013
  4. David L Van Vactor; Fiscal Year: 2016
  5. Role of miR-8 and Ena in Synaptic Structure and Function
    CARLOS MANUEL LOYA; Fiscal Year: 2010
  6. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2012
  7. MECHANISMS OF LEUKOCYTE RECRUITMENT IN IBD
    Ciaran Kelly; Fiscal Year: 2005
  8. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2012
  9. MARK A PEIFER; Fiscal Year: 2016
  10. A Role for Mena in the Heart
    Burns C Blaxall; Fiscal Year: 2012

Detail Information

Publications198 found, 100 shown here

  1. pmc Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes
    Theis Stüven
    ZMBH, INF 282, D 69120 Heidelberg and Universität Lübeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    EMBO J 22:5928-40. 2003
    ..In contrast to a previous report, we found no indications of a major and direct role for CRM1 in actin export from mammalian or insect nuclei...
  2. ncbi NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation
    Noriko Hirao
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
    FEBS Lett 580:6464-70. 2006
    ..Previous studies showed that Abi-1 promotes c-Abl-mediated phosphorylation of Mammalian Enabled (Mena) and WAVE2. In addition to Abi-1, mammals possess Abi-2 and NESH (Abi-3)...
  3. pmc A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family
    K Niebuhr
    Abteilung Zellbiologie und Immunologie AG Molekulare Erkennung, Mascheroder Weg 1, 38124 Braunschweig, Germany
    EMBO J 16:5433-44. 1997
    ..Two profilin binding proteins, VASP and Mena, are the only cellular proteins known so far to bind directly to ActA...
  4. ncbi Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
    S Krugmann
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 11:1645-55. 2001
    ..Cdc42 controls the formation of actin bundle-containing filopodia at the cellular periphery. The molecular mechanism for this remains as yet unclear...
  5. ncbi TES is a novel focal adhesion protein with a role in cell spreading
    Amanda S Coutts
    Cancer Research UK Laboratories, Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    J Cell Sci 116:897-906. 2003
    ..and biochemical analyses yielded interactions with several focal adhesion and/or cytoskeletal proteins including mena, zyxin and talin...
  6. ncbi Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase
    Katsuko Tani
    School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Biol Chem 278:21685-92. 2003
    Mammalian Enabled (Mena) is a mammalian homologue of Drosophila Enabled (Ena), which genetically interacts with Drosophila Abl tyrosine kinase. The signaling pathway involving c-Abl and Mena (Ena) is not fully understood...
  7. pmc The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions
    Boyan K Garvalov
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    J Cell Biol 161:33-9. 2003
    ..Coimmunoprecipitations demonstrate that in vivo Tes is complexed with actin, Mena, and vasodilator-stimulated phosphoprotein (VASP)...
  8. ncbi Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system
    Torsten Giesemann
    Cell Biology, Zoological Institute, Technical University of Braunschweig, D 38092 Braunschweig, Germany
    J Neurosci 23:8330-9. 2003
    ..dynamics, profilin I and neuronal profilin IIa, and with microfilament adaptors of the mammalian enabled (Mena)/vasodilator stimulated phosphoprotein (VASP) family, including neuronal Mena...
  9. ncbi Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
    Matthias Krause
    Department of Biology and Center for Cancer Research, MIT, Cambridge, MA 02139, USA
    Dev Cell 7:571-83. 2004
    Lamellipodial protrusion is regulated by Ena/VASP proteins. We identified Lamellipodin (Lpd) as an Ena/VASP binding protein. Both proteins colocalize at the tips of lamellipodia and filopodia...
  10. ncbi RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
    Esther M Lafuente
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 7:585-95. 2004
    ..RIAM also interacts with Profilin and Ena/VASP proteins, molecules that regulate actin dynamics...
  11. ncbi The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors
    Francesca Di Modugno
    Laboratory of Experimental Chemotherapy, Department of Pathology, Regina Elena Cancer Institute, Rome, Italy
    Clin Cancer Res 12:1470-8. 2006
    hMena (ENAH), a cytoskeleton regulatory protein involved in the regulation of cell motility and adhesion, is overexpressed in breast cancer...
  12. pmc Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines
    Maria S Pino
    Division of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy
    Clin Cancer Res 14:4943-50. 2008
    ..The aim of this study was to determine whether or not the expression of hMena isoforms correlated with sensitivity to EGFR tyrosine kinase inhibitors and could serve as markers with potential clinical use...
  13. pmc Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Exp Metastasis 26:153-9. 2009
    ..One of the genes upregulated in the invasive tumor cells is Mena, an actin binding protein involved in the regulation of cell motility...
  14. pmc A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis
    Ulrike Philippar
    Massachusetts Institute of Technology, Koch Institute, Cambridge, MA 02139, USA
    Dev Cell 15:813-28. 2008
    ..b>Mena, an Ena/VASP protein, is upregulated in the invasive subpopulation of breast cancer cells...
  15. ncbi Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: implications for its role in tumor progression
    Akihiro Toyoda
    Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Int J Oncol 34:53-60. 2009
    The human ortholog of mammalian enabled (hMena), a family of enabled/vasodilator-stimulated phosphoprotein (Ena/VASP), is an actin regulatory protein involved in the regulation of cell motility...
  16. ncbi The immunohistochemical aspects of protein Mena in cervical lesions
    Simona Gurzu
    Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania
    Rom J Morphol Embryol 50:213-6. 2009
    ..In this study, we analyzed the immunohistochemical expression of Mammalian Ena (Mena), which is a member of this family, in the cervical intraepithelial neoplasia (CIN) and also in the cervical ..
  17. doi WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments
    Kazuhide Takahashi
    Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama 241 0815, Japan
    J Cell Biochem 112:3421-9. 2011
    ..After PDGF stimulation, WAVE2, N-WASP, and a mammalian Ena (Mena) colocalized with F-actin at the sites of cell infiltration in a phosphatidylinositol 3-kinase (PI3K)-dependent ..
  18. pmc Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors
    Francesca Di Modugno
    Department of Experimental Oncology, Regina Elena National Cancer Institute, 00158 Rome, Italy
    Proc Natl Acad Sci U S A 109:19280-5. 2012
    Human mena (hMENA), a member of the actin cytoskeleton regulators Ena/VASP, is overexpressed in high-risk preneoplastic lesions and in primary breast tumors and has been identified as playing a role in invasiveness and poor prognosis in ..
  19. ncbi Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response
    Francesca Di Modugno
    Laboratory of Experimental Chemotherapy, Regina Elena Cancer Institute, Rome, Italy
    Int J Cancer 109:909-18. 2004
    ..to 3 different genes, including a novel gene that maps to chromosome 1 and encodes the human homologue of mouse Mena (hMena, cDNA clone RMNY-BR-55), a protein of the Ena/VASP family involved in the regulation of cell motility and ..
  20. ncbi Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding
    Batiste Boëda
    Cell Motility Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Mol Cell 28:1071-82. 2007
    ..Here we show that the LIM3 domain of Tes, which lacks the FPPPP motif, binds to the EVH1 domain of Mena, but not to those of VASP or Evl...
  21. ncbi [Antiphospholipid syndrome and antiphospholipid antibodies as a risk factors of ischaemic heart disease and myocardial infarction in patients with systemic lupus erythematosus]
    Lidia Ostanek
    Klinika Reumatologii PAM w Szczecinie
    Pol Arch Med Wewn 115:407-13. 2006
    ..essays were performed, testing for antinuclear antibodies (ANA), extractable nuclear antigen antibodies (ENA), antiphospholipid antibodies (anticardiolipin antibodies--aCL, lupus anticoagulant--LA, antiprothrombine ..
  22. pmc Release of nitric oxide from glyceryl trinitrate by captopril but not enalaprilat: in vitro and in vivo studies
    D Salvemini
    William Harvey Research Institute, St Bartholomews Hospital Medical College, London
    Br J Pharmacol 109:430-6. 1993
    ..unrelated SH-containing, N-acetylcysteine (NAC, 10 mg kg-1) but not the non-SH-containing ACE-I, enalaprilat (ENA, 5 mg kg-1) were given together with IS-5-MN for the seven days treatment. 2...
  23. doi Modulation of pyrene fluorescence in DNA probes depends upon the nature of the conformationally restricted nucleotide
    Dmytro Honcharenko
    Department of Bioorganic Chemistry, Box 581, Biomedical Center, Uppsala University, SE 75123 Uppsala, Sweden
    J Org Chem 73:2829-42. 2008
    ..locked nucleosides [2'-N-(pyren-1-yl)carbonyl-azetidine thymidine, Aze-pyr (X), and 2'-N-(pyren-1-yl)carbonyl-aza-ENA thymidine, Aza-ENA-pyr (Y)], show that they can bind to complementary RNA more strongly than to the DNA...
  24. ncbi Regional differences in rates of plant speciation and molecular evolution: a comparison between eastern Asia and eastern North America
    Qiu Yun Jenny Xiang
    Department of Botany, North Carolina State University, Raleigh, North Carolina 27695 7612, USA
    Evolution 58:2175-84. 2004
    The eastern Asian (EAS)-eastern North American (ENA) floristic disjunction is one of the best-known biogeographic patterns in the Northern Hemisphere...
  25. ncbi Circulating granulocyte colony-stimulating factor, C-X-C, and C-C chemokines in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome
    Francois Proulx
    Department of Pediatrics, Sainte Justine Hospital, Montreal, Quebec, Canada
    Pediatr Res 52:928-34. 2002
    ..colony-stimulating factor (G-CSF), and the chemokines epithelial cell-derived neutrophil-activating protein-78 (ENA-78), growth related oncogen-alpha (GRO-alpha), macrophage inflammatory protein-1beta (MIP-1beta), and monocyte ..
  26. ncbi Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer
    Ahmed Al-Shukaili
    Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman
    Saudi Med J 27:1873-7. 2006
    ..To investigate the prevalence of a group of different autoantibodies, in Omani patients with gastric cancer, and to examine whether their presence correlates with clinical course of the disease...
  27. ncbi Antibodies to SS-A/Ro-52kD and centromere in autoimmune liver disease: a clue to diagnosis and prognosis of primary biliary cirrhosis
    A Granito
    Department of Internal Medicine, Cardioangiology, Hepatology, Alma Mater Studiorum, University of Bologna, Policlinico Sant Orsola Malpighi, Bologna, Italy
    Aliment Pharmacol Ther 26:831-8. 2007
    ..Primary biliary cirrhosis (PBC) may be associated with various rheumatological disorders...
  28. ncbi Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides
    Dmytro Honcharenko
    Department of Bioorganic Chemistry, Box 581, Biomedical Center, University of Uppsala, S 751 23 Uppsala, Sweden
    Biochemistry 46:5635-46. 2007
    ..1',2'-methylene-bridged (azetidine-T and oxetane-T) nucleosides, North-constrained 2',4'-ethylene-bridged (aza-ENA-T) nucleoside, and 2'-alkoxy modified nucleosides (2'-O-Me-T and 2'-O-MOE-T modifications) have been evaluated and ..
  29. ncbi Absorption, metabolism, and disposition of [14C]SDZ ENA 713, an acetylcholinesterase inhibitor, in minipigs following oral, intravenous, and dermal administration
    F L Tse
    Department of Drug Metabolism and Pharmacokinetics, Preclinical Safety, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA
    Pharm Res 15:1614-20. 1998
    SDZ ENA 713 (rivastigmine) is an acetylcholinesterase inhibitor intended for therapeutic use in Alzheimer's disease...
  30. doi Thermodynamics of charge separation of photosystem I in the menA and menB null mutants of Synechocystis sp. PCC 6803 determined by pulsed photoacoustics
    Harvey J M Hou
    Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts 02747, USA
    Biochemistry 48:1829-37. 2009
    When the biosynthesis of phylloquinone is inhibited in Synechocystis sp. PCC 6803 by interrupting the menA or the menB gene, photosystem I (PS I) recruits plastoquinone-9 (A(P)) to occupy the A(1) sites...
  31. ncbi [Medical treatment of Alzheimer's disease]
    S Lopez-Pousa
    Unitat de Valoració de la Memòria i les Demències, Hospital Santa Caterina, Girona
    Rev Neurol 26:1054-60. 1998
    ..To review the drugs commercially available at present and in the near future in relation to the evolution of Alzheimer disease, bearing in mind the possible psychiatric disorders which may be associated with the disease...
  32. ncbi Relationship between neutrophil-binding affinity and suitability for infection imaging: comparison of (99m)Tc-labeled NAP-2 (CXCL-7) and 3 C-terminally truncated isoforms
    Huub J J M Rennen
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Nucl Med 45:1217-23. 2004
    ..The CXC chemokine interleukin-8 (IL-8) was used for comparison. In addition, a series of (99m)Tc-labeled CXC chemokines were screened for their potential to image infection, including CTAP-III, GCP-2, ENA-78, PF-4, and IP-10.
  33. ncbi Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols
    V Mollace
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London, United Kingdom
    J Pharmacol Exp Ther 258:820-3. 1991
    ..SQ 14,534, the nonsulfhydryl-containing angiotensin-converting enzyme inhibitors, teprotide (TPR) or enalaprilat (ENA) and other structurally unrelated sulfhydryl-containing compounds, N-2-mercaptopropionylglycine (MPG) or N-acetyl-L-..
  34. ncbi Nitrendipine and amlodipine mimic the acute effects of enalapril on renal haemodynamics and reduce glomerular hyperfiltration in patients with chronic kidney disease
    L F Morrone
    Section of Nephrology, Department of Internal Medicine and Public Medicine, University of Bari, Polyclinic, Piazza G Cesare, Bari, Italy
    J Hum Hypertens 17:487-93. 2003
    ..In all, 32 patients (pts), divided into four groups, received the different drugs: ENA (enalapril, eight pts), NIF (nifedipine, eight pts), NIT (nitrendipine, eight pts) AML (amlodipine, eight pts)...
  35. ncbi Anti-extractable nuclear antigens (ENA) antibodies in patients with chronic hepatitis C before and after treatment with interferon
    Katsuhisa Omagari
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Autoimmunity 36:269-73. 2003
    ..However, the prevalence of antibodies to extractable nuclear antigens (anti-ENA) are rarely reported in such patients and the effect of treatment with interferon (IFN) on their prevalence is not ..
  36. doi A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, improved renal microvascular insufficiency in 5/6 nephrectomized rats
    Jinye Song
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, PR China
    Vascul Pharmacol 50:185-93. 2009
    ..N=43), A & A treated group (A & A group, N=40, A & A 12 g/kg/d po), enalapril treated group (Ena group, N=56, enalapril 4 mg/kg/d po)...
  37. ncbi [Definition and consequences of blocking the renin-angiotensin system by converting enzyme inhibition]
    P Sassano
    , , Paris
    Arch Mal Coeur Vaiss 80:1043-7. 1987
    ..In the first group (ENA), 23 patients were given higher dosages of enalapril (40 and, if necessary 60 mg once-a-day)...
  38. ncbi Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis
    Katerina M Antoniou
    Department of Thoracic Medicine, University Hospital, Medical School, University of Crete, Heraklion 71110 Crete, Greece
    Chest 130:982-8. 2006
    ..levels of three angiogenic chemokines (growth-related gene [GRO]-alpha, epithelial neutrophil-activating protein [ENA]-78, and interleukin [IL]-8), and three angiostatic chemokines (monokine induced by interferon (IFN)-gamma [MIG], ..
  39. ncbi The effects of renin-angiotensin system inhibition on regression of encapsulating peritoneal sclerosis
    Devrim Bozkurt
    Department of Nephrology, Ege University, Izmir, Turkey
    Perit Dial Int 28:S38-42. 2008
    ..86%) PD solution-induced peritoneal alterations. Because it shares the same characteristics as other fibrotic processes, peritoneal fibrosis can benefit from RAS blockade...
  40. ncbi Determination of ANA specificity using multiplexed fluorescent microsphere immunoassay in patients with ANA positivity at high titres after infliximab treatment: preliminary results
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Verona, Verona, Italy
    Rheumatol Int 27:649-54. 2007
    ..identification of ANA specificity by multiplexed fluorescent microsphere immunoassay; moreover anti-DNA and anti-ENA antibodies were tested by indirect immunofluorescence and ELISA method, respectively...
  41. doi Autoimmune response following annual influenza vaccination in 92 apparently healthy adults
    N Toplak
    Department of Allergology, Rheumatology and Clinical Immunology, University Children s Hospital, University Medical Centre Ljubljana, Slovenia
    Autoimmun Rev 8:134-8. 2008
    ..To evaluate the possibility of autoimmune responses following annual influenza vaccination in a large cohort of apparently healthy adults...
  42. ncbi Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
    J R White
    Department of Molecular Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 273:10095-8. 1998
    ..oncogene (GRO)alpha, GRObeta, GROgamma, and epithelial cell-derived neutrophil-activating peptide-78 (ENA-78), are potent neutrophil chemotactic and activating peptides, which are proposed to be major mediators of ..
  43. doi Concentration of antibodies to extractable nuclear antigens and disease activity in systemic lupus erythematosus
    S Agarwal
    Department of Rheumatology, Guy s Hospital, London, UK
    Lupus 18:407-12. 2009
    ..On the contrary, the relationship between disease activity in SLE and anti-extractable nuclear antigen (ENA) antibodies has not been well demonstrated...
  44. ncbi QX-314 inhibits ectopic nerve activity associated with neuropathic pain
    I Omana-Zapata
    Department of Analgesia, Roche Bioscience, Palo Alto, CA 94304, USA
    Brain Res 771:228-37. 1997
    ..of Na+ channels in the membrane at nerve injury sites may contribute to the development of ectopic nerve activity (ENA)...
  45. ncbi Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats
    T Kosasa
    Tsukuba Research Laboratories, Eisai, 5 1 3 Tokodai, Tsukuba, Japan
    Eur J Pharmacol 389:173-9. 2000
    ..hydrochloride), (S)-N-ethyl-3-[(1-dimethyl-amino)ethyl]-N-methyl-phenylcarbamate hydrogentartrate (ENA-713, rivastigmine) and 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4, 5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone ..
  46. ncbi Epithelial cell-derived neutrophil-activating peptide-78 is present in fetal membranes and amniotic fluid at increased concentrations with intra-amniotic infection and preterm delivery
    J A Keelan
    Liggins Institute and Department of Pharmacology and Clinical Pharmacology, University of Auckland Faculty of Medical and Health Sciences, Auckland, New Zealand
    Biol Reprod 70:253-9. 2004
    Intra-amniotic secretion and abundance of epithelial cell-derived neutrophil-activating peptide (ENA)-78, a potent chemoattractant and activator of neutrophils, was studied in the context of term and preterm parturition...
  47. doi The influence of luting systems on the microtensile bond strength of dentin to indirect resin-based composite and ceramic restorations
    Camillo D'Arcangelo
    Department of Operative Dentistry, Dental School, University of Chieti, Chieti, Italy
    Oper Dent 34:328-36. 2009
    ..to be used: two etch-and-rinse luting agents (XP bond/CoreXFlow; Dentsply [XP]) (Enabond/EnaCem HF; Micerium [ENA]), a self-etch luting system (ED Primer II A+B/Panavia F2...
  48. ncbi Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop
    J A West-Mays
    Vision Research Laboratories, New England Medical Center, Boston, MA 02111, USA
    Invest Ophthalmol Vis Sci 38:1367-79. 1997
    ..To explore the role of autocrine interleukin-1 alpha (IL-1 alpha) as a central regulator of the repair phenotype in corneal fibroblasts...
  49. ncbi A multiprotein complex consisting of the cellular coactivator p300, AP-1/ATF, as well as NF-kappaB is responsible for the activation of the mouse major histocompatibility class I (H-2K(b)) enhancer A
    D Brockmann
    Institute of Molecular Biology Cancer Research, University of Essen Medical School, Germany
    Gene Expr 8:1-18. 1999
    ..which is recognized by p65/relA in the human HLA system, and (iii) an AP-1/ATF recognition sequence in the 5' end (EnA-TRE)...
  50. pmc Primary and booster mucosal immune responses to meningococcal group A and C conjugate and polysaccharide vaccines administered to university students in the United Kingdom
    Q Zhang
    Sheffield Institute for Vaccine Studies, Division of Child Health, University of Sheffield, Sheffield, United Kingdom
    Infect Immun 69:4337-41. 2001
    ..Saliva samples were collected before and 1 month after the primary and booster vaccinations. Anti-meningococcal A (MenA) and C (MenC) PS IgA and IgG antibody levels were measured by a standard enzyme-linked immunosorbent assay...
  51. ncbi The primary role in biologic activity of the neutrophil chemokines IL-8 and GRO-alpha in cultured nasal epithelial cells
    Claudia Rudack
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Munster, Germany
    J Interferon Cytokine Res 23:113-23. 2003
    ..interleukin8 (IL-8), growth-related oncogene-alpha (GRO-alpha), epithelial cell-derived neutrophil attractant-78 (ENA-78), and granulocyte chemotactic protein-2 (GCP-2) have been detected and characterized and shown to have different ..
  52. ncbi Antinuclear antibody testing in pleural fluid for the diagnosis of lupus pleuritis
    J M Porcel
    Pleural Diseases Unit, Department of Internal Medicine, Arnau de Vilanova University Hospital, IRBLLEIDA, Lleida, Spain
    Lupus 16:25-7. 2007
    ..whether measuring antinuclear antibodies (ANA) and their specificities [dsDNA, extractable nuclear antigens (ENA)] on pleural fluid may contribute to the differential diagnosis of pleural effusions...
  53. ncbi Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis
    Mitsuko Furuya
    Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Hum Pathol 38:1676-87. 2007
    ..In this study, the expression patterns of CXC chemokines (IL-8, ENA-78, GRO-alpha, I-TAC, Mig, and SDF-1) and their receptors (CXCR2, CXCR3, and CXCR4) were compared among 12 ovarian ..
  54. ncbi Different strategies in the laboratory diagnosis of autoimmune disease: immunofluorescence, enzyme-linked immunosorbent assay or both?
    J M Rondeel
    Department of Clinical Chemistry and Haematology, Drechtsteden Hospital, Dordrecht, The Netherlands
    Ann Clin Biochem 36:189-95. 1999
    ..utility of different strategies for antinuclear antibodies (ANA) and antibodies to extractable nuclear antigens (ENA) testing...
  55. ncbi Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity
    T Hayase
    Department of Legal Medicine, Faculty of Medicine, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, 606 8501, Kyoto, Japan
    Pharmacol Biochem Behav 67:151-9. 2000
    ..doses of the CV drugs nimodipine (NIMO), prazosin (PRA), phentolamine (PHEN), propranolol (PRO), and enalapril (ENA) were used with or without the AC drugs diazepam (DZP), phenobarbital (PHB), phenytoin (PHY), and EtOH...
  56. ncbi Naphthalene and beta-naphthoflavone effects on Anguilla anguilla L. hepatic metabolism and erythrocytic nuclear abnormalities
    M Pacheco
    Department of Biology, University of Aveiro, Portugal
    Environ Int 28:285-93. 2002
    ..9 microM BNF. Genotoxicity measured as erythrocytic nuclear abnormalities (ENA) was detected in all BNF treated fish on day 6, whereas on day 9, ENA frequencies returned to control levels, ..
  57. ncbi Biotransformation, genotoxic, and histopathological effects of environmental contaminants in European eel (Anguilla anguilla L.)
    Mario Pacheco
    Animal Physiology Ecotoxicology Sector, Biology Department, University of Aveiro, 3810 193, Aveiro, Portugal
    Ecotoxicol Environ Saf 53:331-47. 2002
    ..Total EROD increases significantly only after 180 days of DHAA exposure. However, significant ENA induction was generally observed during exposure to all contaminants tested...
  58. ncbi Anguilla anguilla L. genotoxic and liver biotransformation responses to abietic acid exposure
    V L Maria
    Department of Biology, Aveiro University, Aveiro 3810 193, Portugal
    Ecotoxicol Environ Saf 58:202-10. 2004
    ..1, 0.3, 0.9, and 2.7 microM abietic acid (AA). Genotoxicity was measured as erythrocytic nuclear abnormalities (ENA), as well as DNA strand breaks in blood and liver...
  59. ncbi Ena/VASP proteins mediate repulsion from ephrin ligands
    Iwan R Evans
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 120:289-98. 2007
    ..Moreover, when EphB4 and ephrin-B2 were expressed in neighbouring Swiss 3T3 fibroblasts, VASP and Mena co-accumulated with activated Eph receptors at protrusions formed by EphB4-expressing cells...
  60. doi Enhanced ENA-78 and IL-8 expression in patients with malignant pancreatic diseases
    Vilma Oliveira Frick
    Department of General, Visceral, Vascular and Paediatric Surgery, University of the Saarland, Homburg Saar, Germany
    Pancreatology 8:488-97. 2008
    ..In the present study we aimed at investigating the expression profile of pro-inflammatory and angiogenic CXC chemokines as potential factors contributing to the aggressive biology of this gastrointestinal malignancy...
  61. doi Bronchoalveolar lavage fluid cellular characteristics, functional parameters and cytokine and chemokine levels in interstitial lung diseases
    M Vasakova
    Department of Respiratory Diseases, 1st Medical School, Charles University, University Thomayer Hospital Prague, Prague, Czech Republic
    Scand J Immunol 69:268-74. 2009
    ..markers were characterized, and MCP-1, MIP-1alpha, MIP-1beta, RANTES, epithelial neutrophil-activating protein (ENA)-78, FGF, G-CSF, GM-CSF, IFN-gamma, interleukin (IL)-1alpha, IL-1RA, IL-1beta, -2beta, -4beta, -5beta, -6beta, -..
  62. ncbi [Prevalence of rheumatic manifestations and non-organ specific autoimmunity in patients with autoimmune thyreopathy]
    K Benhatchi
    I interná klinika Lekárskej fakulty UPJS a FN L Pasteura Kosice, Slovenska republika
    Vnitr Lek 56:106-10. 2010
    ..Aim of this study was to find out the frequency of apperance of non-organ specific antibodies in serum in patients with AIT and prevalence of RM (arthralgia/arthitis)...
  63. pmc Rheumatic disorders and primary biliary cirrhosis: an appraisal of 170 Italian patients
    B Marasini
    Department of Medicine, Surgery and Dentistry, S Paolo Hospital, University of Milan, Milan, Italy
    Ann Rheum Dis 60:1046-9. 2001
    ..To establish the frequency of connective tissue diseases (CTD) in a cohort of Italian patients with primary biliary cirrhosis (PBC) and to evaluate the availability of a marker for the early identification of the more common associated CTD...
  64. ncbi Upregulation of bronchioloalveolar carcinoma-derived C-X-C chemokines by tumor infiltrating inflammatory cells
    M Wislez
    Service de Pneumologie et de Reanimation Respiratoire, AP HP, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Inflamm Res 53:4-12. 2004
    ..We evaluated the role of inflammatory environment on C-X-C chemokine tumor production...
  65. ncbi Differential calcium signaling in dairy cows with specific CXCR1 genotypes potentially related to interleukin-8 receptor functionality
    M Rambeaud
    Department of Animal Science, The University of Tennessee, 114 McCord Hall, 2640 Morgan Circle, Knoxville, TN 37996, USA
    Immunogenetics 59:53-8. 2007
    ..inflammatory mediators, which include interleukin-8 (IL-8) and epithelial-derived neutrophil activating peptide-78 (ENA-78)...
  66. ncbi Evaluation of the BioPlex 2200 ANA screen for the detection of antinuclear antibodies and comparison with conventional methods
    Sophie Desplat-Jego
    Laboratoire d Immunologie, Hopital de la Conception, Marseille, France
    Ann N Y Acad Sci 1109:245-55. 2007
    ..by dsDNA enzyme immunoassay (EliA) test and 657 by double immunodiffusion (DID) for extractable nuclear antigen (ENA) antibodies...
  67. pmc Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein
    Hak Rim Kim
    Dept of Health Sciences, Boston Univ, 635 Commonwealth Ave, Boston MA 02215, USA
    Am J Physiol Cell Physiol 298:C559-71. 2010
    ..However, the underlying mechanisms are largely unknown. Here, we evaluated the possible functions of the Ena/vasodilator-stimulated phosphoprotein (VASP) family of actin filament elongation factors in dVSMC...
  68. pmc Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression
    C M Thorpe
    Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
    Infect Immun 69:6140-7. 2001
    ..multiple C-X-C chemokines at the mRNA level, including interleukin-8 (IL-8), GRO-alpha, GRO-beta, GRO-gamma, and ENA-78. Like that of IL-8, GRO-alpha and ENA-78 mRNAs are both induced and superinduced by Stx1...
  69. ncbi Serendipitous findings from an Illinois ED nursing educational survey reflect a crisis in emergency nursing
    Vicki A Keough
    Loyola University Chicago, Ill, USA
    J Emerg Nurs 29:17-22. 2003
    A survey conducted by the Research Council Of Illinois ENA was intended to assess educational needs, but it revealed some very important serendipitous findings. This survey gave a voice to the frustrations of emergency nurses.
  70. ncbi Prevalence of autoantibodies (ANA, anti ds-DNA, ENA, IMF) and rheumatic syndromes in patients with lymphoproliferative diseases
    A Chloraki-Bobota
    Departments of Immunology, Metaxa Cancer Hospital, Piraeus, Greece
    J BUON 11:485-9. 2006
    ..The purpose of this study was to determine the frequency of simultaneous presentation of both lymphoma or other lymphoproliferative diseases, and rheumatic syndromes...
  71. ncbi [Studies on tsutsugamushi disease in Gifu prefecture. 4. Survey results in Ena and Takayama City, and the summary of the studies in the prefecture]
    S Kasuya
    Department of Parasitology, Gifu University School of Medicine
    Kansenshogaku Zasshi 65:151-6. 1991
    Investigations of trombiculid mites and Rickettsia tsutsugamushi in wild rodents were made in Ena (Nov. 1988) and Takayama (May 1989) City. In the former area where no patient has been reported so far, Leptotrombidium pallidum (63...
  72. ncbi Effect of double-stranded RNA on the expression of epithelial neutrophil activating peptide-78/CXCL-5 in human endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Inflammation 28:215-9. 2004
    Epithelial neutophil activating peptide-78 (ENA-78)/CXCL-5 is a member of CXC chemokines. ENA-78 was originally described as a factor produced by epithelial cells only...
  73. pmc Caenorhabditis elegans WASP and Ena/VASP proteins play compensatory roles in morphogenesis and neuronal cell migration
    Jim Withee
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3204, USA
    Genetics 167:1165-76. 2004
    We report here that WASP and Ena/VASP family proteins play overlapping roles in C. elegans morphogenesis and neuronal cell migration...
  74. pmc Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois
    J Clin Invest 94:1012-8. 1994
    ..we have examined the production of the novel PMN chemotactic cytokine, epithelial neutrophil activating peptide-78 (ENA-78), using peripheral blood, synovial fluid, and synovial tissue from 70 arthritic patients...
  75. pmc Modeling of the P700+ charge recombination kinetics with phylloquinone and plastoquinone-9 in the A1 site of photosystem I
    Vladimir P Shinkarev
    Department of Biochemistry, University of Illinois at Urbana Chamnpaign, 156 Davenport Hall, 607 Mathews Avenue, Urbana, IL 61801 3838, USA
    Biophys J 83:2885-97. 2002
    ..PS I complexes isolated from menA and menB mutants contain plastoquinone-9 rather than phylloquinone in the A(1) site and show altered rates of ..
  76. ncbi Alveolar granulocyte colony-stimulating factor and alpha-chemokines in relation to serum levels, pulmonary neutrophilia, and severity of lung injury in ARDS
    Franz J Wiedermann
    Departments of Anesthesiology and Critical Care Medicine, Leopold Franzens University of Innsbruck, Innsbruck, Austria
    Chest 125:212-9. 2004
    To determine granulocyte colony-stimulating factor (G-CSF), epithelial neutrophil-activating peptide (ENA)-78, and interleukin (IL)-8 in BAL fluid (BALF), epithelial lining fluid (ELF), and serum for establishing the concentration ..
  77. ncbi ENA's Delphi study on national research priorities for emergency nurses in the United States
    Elizabeth W Bayley
    Widener University School of Medicine, Chester, PA, USA
    J Emerg Nurs 30:12-21. 2004
    ..This study identified and prioritized research questions with greatest value to emergency nurses and of highest importance for health care consumers...
  78. ncbi Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion
    D L Rowell
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Am J Physiol 273:G322-32. 1997
    ..interleukin-8(IL-8), growth related (GRO)-alpha, GRO-beta, GRO-gamma, epithelial neutrophil activating peptide-78 (ENA-78), and RANTES] and the cytokines tumor necrosis factor-alpha (TNF-alpha) and macrophage colony stimulating factor ..
  79. pmc Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains
    S M Ahern-Djamali
    McArdle Laboratory for Cancer Research and Laboratory of Genetics University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Mol Biol Cell 9:2157-71. 1998
    Drosophila Enabled (Ena) was initially identified as a dominant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member of the Ena/human vasodilator-stimulated phosphoprotein (VASP) family of ..
  80. ncbi [Gender differences in alcohol consumption in Mexico City]
    J J Caraveo-Anduaga
    Departamento de Investigación en Servicios de Salud, Instituto Mexicano de Psiquiatria, Mexico
    Salud Publica Mex 41:177-88. 1999
    ..in alcohol consumption in the female population registered by results from the National Surveys on Addictions (ENA), 1988 and 1993; and 2) to determine affected age groups, and obtain basic information on age of onset, amount ..
  81. ncbi Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity
    J L Juang
    National Health Research Institute, 128 Yen Chiu Yuan Road, Sec 2, Taipei, Taiwan
    Oncogene 18:5138-47. 1999
    ..Both proteins activate the kinase activity of Abl as assayed by phosphorylation of the Drosophila Enabled (Ena) protein. Removal of the dAbi SH3 domain eliminates dAbi's activation of Abl kinase activity...
  82. ncbi Directed actin polymerization is the driving force for epithelial cell-cell adhesion
    V Vasioukhin
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Cell 100:209-19. 2000
    ..Opposing cell surfaces are clamped by desmosomes, while vinculin, zyxin, VASP, and Mena are recruited to adhesion zippers by a mechanism that requires alpha-catenin...
  83. ncbi Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition
    J Beneken
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 26:143-54. 2000
    Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins...
  84. ncbi Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils
    N T Luu
    Department of Physiology, The Medical School, University of Birmingham, Birmingham, United Kingdom
    J Immunol 164:5961-9. 2000
    ..plasma (a source of activated complement factor C5a), epithelial cell-derived neutrophil-activating peptide (ENA-78), or growth-regulating oncogene, GRO-alpha, was perfused over these neutrophils, they stopped rolling and ..
  85. pmc Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization
    Marcus Geese
    Department of Cell Biology, Gesellschaft fur Biotechnologische Forschung, D 38124 Braunschweig, Germany
    Mol Biol Cell 13:2383-96. 2002
    ..the identification and characterization of key regulators of the actin cytoskeleton such as the Arp2/3 complex and Ena/vasodilator-stimulated phosphoprotein (VASP) proteins...
  86. ncbi Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics?
    Bernhard Schick
    Department of Otolaryngology, Head and Neck Surgery, University of Homburg Saar, Kirrberger Strasse, D 66421 Homburg Saar Germany
    Cell Tissue Res 311:315-23. 2003
    Vasodilator-stimulated phosphoprotein (VASP) is a member of the ENA/VASP-protein family. VASP is considered to be a crucial factor in the regulation of actin dynamics, which involves processes such as motility and cell adhesion, e.g...
  87. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
    ..Abl acts at least in part via the actin regulator Enabled (Ena), but the mechanism by which Abl regulates Ena is unknown...
  88. ncbi Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end
    Marisan R Mejillano
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Cell 118:363-73. 2004
    ..In Ena/VASP deficient cells, CP depletion resulted in ruffling instead of filopodia...
  89. ncbi Sparus aurata L. liver EROD and GST activities, plasma cortisol, lactate, glucose and erythrocytic nuclear anomalies following short-term exposure either to 17beta-estradiol (E2) or E2 combined with 4-nonylphenol
    M Teles
    Biology Department, Campus de Santiago, Aveiro University, 3810 193 Aveiro, Portugal
    Sci Total Environ 336:57-69. 2005
    ..Genotoxicity was assessed through erythrocytic nuclear anomalies (ENA) frequency...
  90. ncbi Tissue-specific Spred-2 promoter activity characterized by a gene trap approach
    Karin Bundschu
    Institut für Klinische Biochemie und Pathobiochemie, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Gene Expr Patterns 6:247-55. 2006
    Spreds (Sprouty-related proteins with an Ena/Vasodilator-stimulated phosphoprotein homology-1 domain) are a new protein family inhibiting the mitogen-activated protein kinase (MAPK) signaling pathway...
  91. ncbi Cytokine gene expression profiles in human lymphocytes induced by a formula of traditional Chinese medicine, vigconic VI-28
    Qiang Pan-Hammarstrom
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, SE 14186 Stockholm, Sweden
    J Interferon Cytokine Res 26:628-36. 2006
    ..IL-1), growth-related protein-beta (GRO-beta) and epithelial cellderived neutrophil-activating peptide (ENA-78 [CXCL5])...
  92. ncbi High-stability semiquinone intermediate in nitrate reductase A (NarGHI) from Escherichia coli is located in a quinol oxidation site close to heme bD
    Pascal Lanciano
    Unité de Bioénergétique et Ingénierie des Protéines UPR9036, Institut de Biologie Structurale et de Microbiologie, CNRS and Université d Aix Marseille, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochemistry 46:5323-9. 2007
    ..out on the NarGHIK86A mutant reveal that the substitution dramatically reduces the rate of oxidation of both mena and ubiquinol analogues...
  93. ncbi Dispensing an enzyme-conjugated solution into an ELISA plate by adapting ink-jet printers
    Luca Lonini
    University Campus Bio Medico, Via Longoni 83 00155 Rome, Italy
    J Biochem Biophys Methods 70:1180-4. 2008
    ..We employed an ELISA diagnostic kit for the qualitative screening of anti-ENA antibodies to verify the ability of the dispensed immunoglobulins to bind the primary antibodies in the wells...
  94. pmc A phase II, randomized study on an investigational DTPw-HBV/Hib-MenAC conjugate vaccine administered to infants in Northern Ghana
    Abraham Hodgson
    Navrongo Health Research Centre, Ministry of Health, Navrongo, Ghana
    PLoS ONE 3:e2159. 2008
    ..We have evaluated the immunogenicity, persistence of immune response, immune memory and safety of an investigational DTPw-HBV/Hib-MenAC conjugate vaccine given to infants in Northern Ghana...
  95. pmc FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging
    Kana Miyamoto
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinano machi, Tokyo, Japan
    Blood 112:4485-93. 2008
    ..associated with inhibition of the up-regulation of negative regulator of cell proliferation, Sprouty-related Ena/VASP homology 1 domain-containing proteins 2 (Spred2) and AKT and ERK activation, in HSCs during hematopoietic ..
  96. ncbi CC and CXC chemokines patterns in psoriasis determined by protein array method were influenced by Goeckerman's therapy
    David Pohl
    Department of Clinical Immunology and Allergy, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:9-13. 2009
    ..study was to evaluate the influence of Goeckerman's therapy of psoriasis on the levels of proangiogenic chemokines ENA-78 (CXCL5, Epithelial Cell Derived Neutrophil Attractant-78), GRO alpha (CXCL1, Growth-Related Oncogene), IL-8 (..
  97. pmc Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling
    Faraz K Mardakheh
    Cancer Research UK Growth Factor Group, University of Birmingham, Birmingham B15 2TT, England, UK
    J Cell Biol 187:265-77. 2009
    ..We examined the regulation of fibroblast growth factor (FGF) signaling by Sprouty related with EVH1 (Ena/VASP homology 1) domain (Spred), a family of signaling inhibitors with proposed tumor-suppressive functions...
  98. doi Genetic structure and dispersal patterns of the invasive psocid Liposcelis decolor (Pearman) in Australian grain storage systems
    K M Mikac
    Institute for Applied Ecology, University of Canberra, Bruce, ACT, 2601, Australia
    Bull Entomol Res 100:521-7. 2010
    ..05-0.23). Due to suspected null alleles at four loci, ENA (excluding null alleles) corrected FST estimates were calculated overall and for pairwise population comparisons...
  99. doi HYSCORE evidence that endogenous mena- and ubisemiquinone bind at the same Q site (Q(D)) of Escherichia coli nitrate reductase A
    Rodrigo Arias-Cartin
    Laboratoire de Chimie Bactérienne UPR9043, CNRS and Aix Marseille Université, 31 Chemin J Aiguier, 13009 Marseille, France
    J Am Chem Soc 132:5942-3. 2010
    ..They also provide the first direct experimental evidence for similar binding of natural menasemiquinones and ubisemiquinones within the same protein Q site of NarGHI...
  100. ncbi Modification and implementation of NCCN guidelines on hepatobiliary cancers in the Middle East and North Africa region
    Muhammed Aasim Yusuf
    Department of Gastroenterology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
    J Natl Compr Canc Netw 8:S36-40. 2010
    ..Hepatocellular cancer incidence is higher in the Middle East and North Africa (MENA) region than in the West, and hepatitis B and C infections are particularly important; the incidence of gallbladder ..
  101. doi Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination
    Motoki Takaku
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo, Japan
    J Biochem 149:721-9. 2011
    b>MENA, VASP and EVL are members of the ENA/VASP family of proteins and are involved in cytoplasmic actin remodeling...

Research Grants61

  1. Michelle L Gumz; Fiscal Year: 2014
    ..By characterizing the role of the circadian clock protein Per1 in the regulation of renal sodium transport, we can begin to understand the connection between the circadian clock, kidney function and blood pressure. ..
  2. Mary C Beckerle; Fiscal Year: 2015
    ..A Stress Fiber-Remodeling, Repair, and Reinforcement (SF-R3) complex that includes zyxin, Ena-VASP proteins, and 1-actinin, has been identified...
  3. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2013
    ..Consistent with this, PMR1 binds to the Ena/VASP proteins, which are regulators of the actin cytoskeleton, and cell motility is increased in cells ex- pressing ..
  4. David L Van Vactor; Fiscal Year: 2016
    ..mechanisms downstream of miR-8, we have shown that postsynaptic repression of the actin-associated protein Enabled (Ena) plays an important role in controlling NMJ growth in late larval stages, consistent with the localization of Ena ..
  5. Role of miR-8 and Ena in Synaptic Structure and Function
    CARLOS MANUEL LOYA; Fiscal Year: 2010
    ..step, we will perform a comprehensive study of the role of the conserved microRNA, miR-8, and its functional target Ena, at the synapse...
  6. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2012
    ..b>Ena/VASP proteins function in growth cone guidance by controlling actin cytoskeleton dynamics...
  7. MECHANISMS OF LEUKOCYTE RECRUITMENT IN IBD
    Ciaran Kelly; Fiscal Year: 2005
    ..long-term goal of this project is to determine the mechanisms whereby Epithelial Neutrophil-Activating peptide-78 (ENA-78), produced by activated enterocytes, regulates neutrophil recruitment in inflammatory bowel disease...
  8. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2012
    ..b>Mena, VASP and EVL, highly related proteins that comprise the Ena/VASP family, play pivotal roles in movement and shape ..
  9. MARK A PEIFER; Fiscal Year: 2016
    ..We also defined roles in morphogenesis of two key actin regulators: Ena/VASP proteins and Dia-class formins...
  10. A Role for Mena in the Heart
    Burns C Blaxall; Fiscal Year: 2012
    Heart failure (HF) is associated with myriad changes in cardiac gene expression. We recently found expression of Mena to be a novel predictor of HF...
  11. Russell E McConnell; Fiscal Year: 2014
    ..migrated out of a primary tumor in response to Epidermal Growth Factor (EGF) had increased expression levels of Mena, one of three members of the Ena/VASP family...
  12. CLONAL DOMINANCE OF HEMATOPOIETIC STEM CELLS EXPRESSING MUTANT CSF3R
    Daniel C Link; Fiscal Year: 2013
    ..two candidate genes that are differentially induced by G-CSF in d715 G-CSFR HSC: Cdkn1a (p21cip1/waf1) and Enah. We hypothesize that induction of Cdkn1a expression by the d715 G-CSFR allows for HSC proliferation without loss of ..
  13. Amira A Roess; Fiscal Year: 2014
    ..among IDUs at 63% (Saleh 1998), indicating that this group is particularly vulnerable to HCV-HIV co-infection (MENA Synthesis Report, UNAIDS 2009)...
  14. Identifying the Mechanisms Governing Mena-Induced Tumor Cell Dissemination
    Minna Roh; Fiscal Year: 2013
    ..One of the components of the "Invasion Signature" is Mena, a member of the Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) family...
  15. Extended NeuroAmides: Novel Antiepileptic Drug Candidates
    Harold Kohn; Fiscal Year: 2012
    ..b>ENA Na+ channel SI activity far exceeded that of any reported anticonvulsant agent...
  16. Crucial Transitions among Young Opioid Users in Iran
    Mohsen Malekinejad; Fiscal Year: 2011
    ..developmental study into crucial areas of drug use and HIV prevention in the Middle East and North Africa (MENA) region...
  17. A Culturally Informed Tele-Intervention for Minority High Risk Youth and Parents
    Daniel A Santisteban; Fiscal Year: 2010
    ..manual to tailor of the treatment to the unique characteristics and needs of minority families (Santisteban &Mena, in press)...
  18. Roundabout4 signaling in endothelial cells
    Ramani Ramchandran; Fiscal Year: 2012
    ..signaling molecules at both the cell surface and intracellular level;(B) A complex of proteins including IRSp53, Mena, Cdc42-GTP, and Vilse together assemble in endothelial cells in response to Robo4; (C) Members of the Sry-related ..
  19. Role of Protein Kinase D in Actin Remodeling and Cell Motiliy
    Peter Storz; Fiscal Year: 2013
    ..of the WASp family and the Arp2/3 complex, which induce actin nucleation and dendritic branching, as well as Ena/VASP, which competes with the capping protein (CP)...
  20. Functions of Epithelial Splicing Regulatory Proteins and their role in the EMT
    RUSS PAUL CARSTENS; Fiscal Year: 2013
    ..Further identification of CD44, ENAH, and p120-ctn as splicing targets of ESRP1 and ESRP2 implicates these proteins as the regulators of a broader ..
  21. MAJA HRZENJAK OKTAY; Fiscal Year: 2015
    ..intravasation- competent primary human breast cancer cells express unique isoforms of an actin regulatory protein Mena that are related to an intravasation signature;4) cancer cells with high MenaINV and low Mena11a isoform expression ..
  22. The role of RIAM in T cell immunity and tolerance
    Vassiliki A Boussiotis; Fiscal Year: 2013
    ..C-terminal region with multiple FPPPP motifs interacting with the EVH1 domains of the actin regulatory proteins Ena/VASP and multiple XPPPP motifs interacting with profilin...
  23. Regulation of alternative splicing by microenvironment signaling
    MATTHEW SEAN MARENGO; Fiscal Year: 2011
    ..Preliminary research suggests that the regulation of FGFR2 and Enah exon skipping events is linked to mammary tumor progression...
  24. David R Sherwood; Fiscal Year: 2015
    ..signaling in selecting a single invadosome for basement membrane invasion, (3) the function of the actin regulator Ena/VASP in promoting basement membrane gap expansion at the anchor cell-basement membrane contact points after ..
  25. Daniel A Santisteban; Fiscal Year: 2014
    ..unique family characteristics, 2) showed highly promising feasibility and acceptability indicators (Santisteban and Mena, in press) and 3) showed highly promising preliminary outcomes on both drug use and family-level hypothesized ..
  26. Exploratory Evaluation of MSM Social Networks and HIV Risk Behavior in Lebanon
    GLENN JOHN WAGNER; Fiscal Year: 2012
    ..by applicant): Men who have sex with men (MSM) account for many of the new infections in Lebanon and other parts of MENA, and act as a bridge to transmission in the general population;yet this population remains very much understudied ..
  27. MUHAMMAD HAMID ZAMAN; Fiscal Year: 2016
    ..One such example is Mena, a member of the Ena/VASP family of actin regulatory proteins, which has been characterized for aberrant cell-..
  28. BEHAVIORALLY INDUCED SNS AROUSAL AND SODIUM REGULATION
    Gregory Harshfield; Fiscal Year: 1990
    ..on the renal handling of sodium (Na+) and the hemodynamic and humoral factors mediating changes in Na+ excretion (ENa+). The specific aims are to answer the following questions in man: 1...
  29. MENA Think Tank Stigma and HIV Prevention
    ANKE EHRHARDT; Fiscal Year: 2009
    ..Moroccan Ministry of Health and the UCLA Program in Global Health, propose to conduct a Middle East/North Africa (MENA)-specific Think Tank on HIV/AIDS stigma and HIV prevention...
  30. PATHOGENIC MECHANISMS OF HELICOBACTER PYLORI GASTRITIS
    Ciaran Kelly; Fiscal Year: 2002
    ..These factors then up- regulate IL-8 gene transcription. ENA-78 is an epithelial cell-derived chemokine structurally and functionally similar to IL-8. Cag+ H...
  31. Alcohol in Mexican-Origin Groups: US and Mexican Surveys
    Marjorie Robertson; Fiscal Year: 2004
    ..Surveys (NASs), each including large Hispanic oversamples, and the 1998 Mexican National Survey of Addictions (ENA) conducted by our collaborators at the National Institute of Psychiatry, Mexico City...
  32. Menaquinone biosynthesis: a drug target in Gram-positive bacteria
    Dean Crick; Fiscal Year: 2007
    Project Summary: Potent inhibitors of menaquinone synthesis (specifically MenA) in M. tuberculosis have been identified, which are also effective inhibitors of mycobacterial growth...
  33. DELTAVISION MULTI-MODE DECONVOLUTION MICROSCOPE
    Martha Constantine Paton; Fiscal Year: 2000
    ..Its immediate goal is to determine how the Mena protein regulates the actin cytoskeleton...
  34. Regulation of Microglial Activation
    Carol Colton; Fiscal Year: 2003
    ..Since our preliminary data demonstrate that microglial immune activation promotes a gene switching process, whereby mENA for CAT1 appears repressed and CAT2b mRNA appears enhanced, we will investigate the gene induction process and the ..
  35. Studies on Vitamin K Biosynthesis
    RANGASWAMY MEGANATHAN; Fiscal Year: 2002
    ..menB-->{ 1, 4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA)}---menH---> 1, 4-dihydroxy-2-naphthoic acid (DHNA) ---menA---> demethylmenaquinone (DMK) --- ubiE --> menaquinone (MK)...
  36. Surface-bound Regulation of Actin Polymerization
    SCOT KUO; Fiscal Year: 2009
    ..By examining ARP2/3 and Ena/VASP-dependent reactions, we will probe the physicochemical constraints of membrane-surface catalysis in two modes ..
  37. STRUCTURAL BIOLOGY OF CYTOSKELETAL DYNAMICS
    STEVEN ALMO; Fiscal Year: 2003
    ..Scaffolding proteins of the Ena/VASP/WASP family participate in the formation of multicomponent assemblies that direct the site specific, de novo ..
  38. The role of Ena/VASP proteins in muscle development
    KATHERINE KRAGTORP; Fiscal Year: 2006
    The role of Ena/VASP proteins in the organization of the actin cytoskeleton and the regulation of cell motility and axon outgrowth has been well established...
  39. Enabled, a regulator of adhesion and cell motility
    Julie Gates; Fiscal Year: 2005
    ..Recent studies have revealed that members of the Ena/VASP protein family not only promote cell adhesion, but also inhibit cell motility by regulating localized actin ..
  40. Analysis of Ena/VASP Anti-Capping Activity
    Craig Furman; Fiscal Year: 2005
    ..b>Ena/VASP proteins are key regulators of cell migration...
  41. Cytoskeletal Responses to Guidance Signaling
    ELAINE PINHEIRO; Fiscal Year: 2007
    ..This proposal addresses the role of Mena, the most highly expressed family member in the nervous system, in growth cone guidance...
  42. p190 RhoGAP Regulation and Function
    Jennifer Lamb; Fiscal Year: 2007
    Actin remodeling at the plasma membrane is required for cell migration. The Ena/VASP family of actin regulatory proteins are key regulators of filopodia and lamellipodia dynamics, both environment sensing protrusions involved in ..
  43. REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMA
    Joseph Solomkin; Fiscal Year: 2004
    ..sequence of chemokines, including platelet-released NAP-2, and endothelial and epithelial derived IL-8, GROor, and ENA-78...
  44. The Role of Rap1 in T-Cell Responses
    Vassiliki Boussiotis; Fiscal Year: 2003
    ..RIAM provides a link between Rapl-GTP and the cytoskeleton by interacting with Mena, VASP and WASP and the actin regulator profilin...
  45. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    DEREK APPLEWHITE; Fiscal Year: 2006
    ..transition that bind to the barbed-end of actin filaments, the heterodimeric capping protein (CP) and the Ena/VASP family of molecules...
  46. CHEMOKINE GENE REGULATION IN HUMAN CORNEAL EPITHELIA
    John Oakes; Fiscal Year: 2003
    ..that the same combination of transcriptional factors that activate IL-8 expression will also activate expression of ENA-78, a a-chemokine whose promoter possesses both sequence homology and structure similarity to the IL-8 promoter...
  47. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..These studies will help to elucidate novel mechanisms in SCF-mediated hepatocyte protection and regeneration in a clinically relevant liver resection and toxicity model. ..
  48. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2009
    ..To investigate this hypothesis, we will examine specific MIP-2-related mechanisms of hepatocyte proliferation and apoptosis following 70% hepatectomy, as well as IP-10's modulating effects in this system. ..
  49. Biological Role of the FE65 Protein/APP Interactions
    Suzanne Guenette; Fiscal Year: 2009
    ..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..
  50. A biochemical screen for novel regulators of neuronal morphogenesis
    ANTHONY KOLESKE; Fiscal Year: 2007
    ..Identifying these substrate will expand the "toolkit" available to dissect the molecular mechanisms of axon and dendrite morphogenesis. [unreadable] [unreadable]..
  51. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
    ..LIX is related to two human chemokines, ENA-78 and GCP-2, but has some distinctive structural features...
  52. CHEMOKINES REGULATE ANGIOGENESIS IN PULMONARY FIBROSIS
    Michael Keane; Fiscal Year: 2003
    ....
  53. Investigating aging and membrane-associated T cell receptor signaling in human CD
    Insoo Kang; Fiscal Year: 2008
    ..The results of this study will provide important information on enhancing immune responses in the aged populations, leading to improved protection against infections and tumors. [unreadable] [unreadable] [unreadable]..
  54. Pathogen-specific T cell responses in patients with SLE
    Insoo Kang; Fiscal Year: 2008
    ..abstract_text> ..
  55. ATOMIC STRUCTURE OF SMOOTH MUSCLE CALDESMON
    Roberto Dominguez; Fiscal Year: 2004
    ....
  56. Are IQs low in offspring of euthyroid women with low T4
    Wendy Craig; Fiscal Year: 2008
    ..It is intended that the study be continued for five more years (total of 10) in order to obtain additional estimates of neuropsychological development in the children at a time when more extensive testing can be performed. ..
  57. Structure of the Smooth Muscle Myosin Phosphatase
    Roberto Dominguez; Fiscal Year: 2008
    ..This knowledge will prove invaluable for the development of new drugs to treat cardiovascular diseases such as hypertension. ..
  58. SHIGA TOXIN INDUCED INFLAMMATION AND THROMBOSIS
    Adrian Gear; Fiscal Year: 2004
    ..Finally, the role of proteases in the Shiga-toxin effects on platelet function will be examined. ..
  59. Effect of autoantibodies on lung fibroblast phenotype
    JEAN PFAU; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  60. Light Adaptation in Cone Photoreceptors
    FREDERICK SOO; Fiscal Year: 2007
    ..A suction electrode technique is used throughout, which allows recording from individual, intact photoreceptors. ..