EGR2

Summary

Gene Symbol: EGR2
Description: early growth response 2
Alias: AT591, CMT1D, CMT4E, KROX20, E3 SUMO-protein ligase EGR2, KROX-20, Drosophila, homolog (early growth response-2), early growth response protein 2, zinc finger protein Krox-20
Species: human

Top Publications

  1. ncbi The one-to-four rule and paralogues of sex-determining genes
    S Ohno
    Beckman Research Institute of the City of Hope, Duarte, California 91010 3000, USA
    Cell Mol Life Sci 55:824-30. 1999
  2. ncbi A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease
    E Bellone
    Department of Oncology, Biology and Genetics, University of Genova, Genova Italy
    Hum Mutat 14:353-4. 1999
  3. pmc HCF-1 functions as a coactivator for the zinc finger protein Krox20
    Randy L Luciano
    Department of Microbiology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 278:51116-24. 2003
  4. ncbi Novel EGR2 mutation R359Q is associated with CMT type 1 and progressive scoliosis
    E Mikesová
    Department of Child Neurology, 2nd School of Medicine, Charles University Prague, V Uvalu 84, 15006 Prague, Czech Republic
    Neuromuscul Disord 15:764-7. 2005
  5. ncbi Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    FEBS Lett 554:67-72. 2003
  6. pmc Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism
    Susan E Swanberg
    Department of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
    Hum Mol Genet 18:525-34. 2009
  7. doi MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2
    Qiong Wu
    Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Biochem Biophys Res Commun 392:340-5. 2010
  8. doi No association between EGR gene family polymorphisms and schizophrenia in the Chinese population
    Bao Cheng Liu
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 34:506-9. 2010
  9. doi EGR3 as a potential susceptibility gene for schizophrenia in Korea
    Se Hyun Kim
    Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 153:1355-60. 2010
  10. ncbi Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene
    Ikuko Yokota
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    Int J Oncol 37:1407-16. 2010

Research Grants

  1. Genetic and Functional Profiles of Serotonergic Neuron Subtypes
    Rachael D Brust; Fiscal Year: 2013
  2. William S Talbot; Fiscal Year: 2016
  3. Exploring the Role of Egr2 in the Alternative Activation of Macrophages
    Achsah D Keegan; Fiscal Year: 2013
  4. Regulation of Myelination by Egr2/Nab Protein Complexes
    Jeffrey Milbrandt; Fiscal Year: 2009
  5. KROX 20 AND BONE MASS
    Baruch Frenkel; Fiscal Year: 2010
  6. JONATHAN D CHERNOFF; Fiscal Year: 2016
  7. Thomas F Gajewski; Fiscal Year: 2016
  8. Regulation of Monocyte and Granulocyte Lineage Specification
    Alan D Friedman; Fiscal Year: 2013
  9. CMT Peripheral Neuropathy: IV. Genes and Pathogenesis
    JAMES LUPSKI; Fiscal Year: 2005
  10. Zinc finger nuclease induced knockout and knock-in models in zebrafish
    Meera T Saxena; Fiscal Year: 2011

Patents

  1. T cell activating gene

Detail Information

Publications266 found, 100 shown here

  1. ncbi The one-to-four rule and paralogues of sex-determining genes
    S Ohno
    Beckman Research Institute of the City of Hope, Duarte, California 91010 3000, USA
    Cell Mol Life Sci 55:824-30. 1999
    ..One consisted of EGR1, EGR2, EGR3 and EGR4, whereas the only known paralogue of the other is WT1, which controls the developmental fate of the ..
  2. ncbi A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease
    E Bellone
    Department of Oncology, Biology and Genetics, University of Genova, Genova Italy
    Hum Mutat 14:353-4. 1999
    ..Recently point mutations in the early growth response 2 gene (EGR2/Krox-20) have been associated with hereditary myelinopathies...
  3. pmc HCF-1 functions as a coactivator for the zinc finger protein Krox20
    Randy L Luciano
    Department of Microbiology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 278:51116-24. 2003
    ..Three well characterized examples were further analyzed for their ability to use HCF-1 as a coactivator. Krox20, a zinc finger transcription factor required for Schwann cell differentiation, and E2F4, a cell cycle regulator, ..
  4. ncbi Novel EGR2 mutation R359Q is associated with CMT type 1 and progressive scoliosis
    E Mikesová
    Department of Child Neurology, 2nd School of Medicine, Charles University Prague, V Uvalu 84, 15006 Prague, Czech Republic
    Neuromuscul Disord 15:764-7. 2005
    Mutations in the early growth response 2 gene (EGR2) cause demyelinating neuropathies differing in severity and age of onset...
  5. ncbi Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    FEBS Lett 554:67-72. 2003
    We previously demonstrated several lines of evidence indicating that early growth response 2 (EGR2) functions as a tumor suppressor, partly on the basis that its expression was often decreased in human tumors and cancer cell lines...
  6. pmc Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism
    Susan E Swanberg
    Department of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
    Hum Mol Genet 18:525-34. 2009
    ..The activity-dependent early growth response gene 2 (EGR2), required for both early hindbrain development and mature neuronal function, has predicted binding sites in the ..
  7. doi MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2
    Qiong Wu
    Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Biochem Biophys Res Commun 392:340-5. 2010
    ..Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150...
  8. doi No association between EGR gene family polymorphisms and schizophrenia in the Chinese population
    Bao Cheng Liu
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 34:506-9. 2010
    ..In this study we investigated the role of EGR1, EGR2, EGR3 and EGR4 within the EGR family...
  9. doi EGR3 as a potential susceptibility gene for schizophrenia in Korea
    Se Hyun Kim
    Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 153:1355-60. 2010
    ..EGR genes, including EGR2, EGR3, and EGR4, showed significant association with schizophrenia in Japanese schizophrenic pedigrees...
  10. ncbi Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene
    Ikuko Yokota
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    Int J Oncol 37:1407-16. 2010
    ..Using microarray analysis, we have identified the transcription factor early growth response 2 (EGR2) as a target of the p53 family, specifically p53, p63 and p73...
  11. pmc Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination
    Ye He
    Department of Neuroscience and Genetics and Genomics, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1472-80. 2010
    ..The Schwann cells expressed low levels of myelin proteins and of Egr2 (also called Krox20), which is an important regulator of peripheral myelination...
  12. pmc Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure
    L J Joseph
    Department of Medicine, Howard Hughes Medical Institute, Chicago, IL
    Proc Natl Acad Sci U S A 85:7164-8. 1988
    ..Using low-stringency hybridization with an Egr-1 cDNA probe, we identified a distinct human cDNA (designated EGR2 for early growth response gene-2), which is coregulated with EGR1 by fibroblast and lymphocyte mitogens; however, ..
  13. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
    ..Therefore Krox-20 is likely to control a set of genes required for completion of myelination in the peripheral nervous system...
  14. ncbi EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japam
    Oncogene 22:2172-85. 2003
    b>EGR2 plays a key role in the PTEN-induced apoptotic pathway...
  15. ncbi Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation
    D Pareyson
    Departments of Neurology, C Besta National Neurological Institute, Milan, Italy
    Neurology 54:1696-8. 2000
    Mutations in the gene coding for the Schwann cell transcription factor early growth response 2 (EGR2), which seems to regulate myelinogenesis and hindbrain development, have been observed in few cases of inherited neuropathy...
  16. pmc Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor
    Eric D Phelps
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Infect Immun 76:4703-12. 2008
    ..Early growth response 2 (EGR2) is a host cell transcription factor that is rapidly upregulated and activated in Toxoplasma-infected cells but not ..
  17. ncbi Embryology of the neural crest: its inductive role in the neurocutaneous syndromes
    Harvey B Sarnat
    Department of Pediatrics Neurology, University of Calgary, Faculty of Medicine, Alberta Children s Hospital, Calgary, AB, Canada
    J Child Neurol 20:637-43. 2005
    ..of the neural tube (eg, PAX3, BMP4, ZIC2), some segmentation genes (eg, WNT1), genes that inhibit neural crest (eg, EGR2), and neural crest-specific differentiating genes (eg, SLUG, SOX10)...
  18. ncbi Regulation of myelin-specific gene expression. Relevance to CMT1
    J Kamholz
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 883:91-108. 1999
    ..Two transcription factors, Krox 20 (EGR2) and Oct 6 (SCIP/Tst1), are necessary for the transition from the promyelinating to the myelinating stage of ..
  19. ncbi Coordinate augmentation in expression of genes encoding transcription factors and liver secretory proteins in hypo-oncotic states
    J Kang
    Department of Biological Chemistry, University of California, Davis 95616, USA
    Kidney Int 56:452-60. 1999
    ..This is the only known condition in which transcription of both positive and negative acute phase proteins (APPs) are increased simultaneously. The specific transcription factor(s) that might regulate this cascade is not defined...
  20. ncbi A novel type of hereditary motor and sensory neuropathy characterized by a mild phenotype
    P De Jonghe
    Department of Biochemistry, University Hospital Antwerp, Belgium
    Arch Neurol 56:1283-8. 1999
    ..2 (CMT1A), 1q21-q23 (CMT1B), and 10q21.1-q22.1 (designated here as CMT1D)...
  21. ncbi Molecular analysis in Japanese patients with Charcot-Marie-Tooth disease: DGGE analysis for PMP22, MPZ, and Cx32/GJB1 mutations
    Chikahiko Numakura
    Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
    Hum Mutat 20:392-8. 2002
    ..myelin protein 22 (PMP22), myelin protein zero (MPZ), connexin 32 (Cx32/GJB1), and early growth response 2 (EGR2) genes. Some mutations of MPZ and Cx32 were also associated with the clinical CMT2 phenotype...
  22. ncbi Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer
    Nathalie Leclerc
    University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:929-39. 2005
    ..Using this gene as a model, the goal of this study was to discover glucocorticoid-sensitive transcriptional mechanisms in osteoblasts...
  23. ncbi Clinical, electrophysiological and molecular genetic studies in a family with X-linked dominant Charcot-Marie-Tooth neuropathy presenting a novel mutation in GJB1 Promoter and a rare polymorphism in LITAF/SIMPLE
    Katell Beauvais
    Unité de Neurophysiologie Clinique, Hôpital Yves Le Foll, 22023 Saint Brieuc, France
    Neuromuscul Disord 16:14-8. 2006
    ..Charcot-Marie-Tooth disease with dominant inheritance, five genes have been incriminated: PMP22, MPZ, LITAF/SIMPLE, EGR2 (CMT1A to D), and GJB1 (CMTX)...
  24. doi 5q- myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics
    K M Eisenmann
    Laboratories of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Oncogene 28:3429-41. 2009
    ..identified candidate tumor-suppressor genes, including the ribosomal subunit RPS14, the transcription factor Egr1/Krox20 and the cytoskeletal remodeling protein, alpha-catenin...
  25. doi Neurofilament light chain polypeptide gene mutations in Charcot-Marie-Tooth disease: nonsense mutation probably causes a recessive phenotype
    Akiko Abe
    Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
    J Hum Genet 54:94-7. 2009
    ..We investigated NEFL in 223 Japanese CMT patients who were negative for PMP22, MPZ, GJB1, LITAF, EGR2, GDAP1, MTMR2 and PRX in the demyelinating form and negative for MFN2, MPZ, GJB1, HSP27, HSP22 and GARS in the ..
  26. doi Clinical characterization and genetic analysis of a possible novel type of dominant Charcot-Marie-Tooth disease
    Yi Chung Lee
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
    Neuromuscul Disord 20:534-9. 2010
    ..No mutation in PMP22, MPZ, GJB1, NEFL, LITAF, EGR2, MFN2, HSP27, HSP22, GADP1, YARS, and DNM2 genes was found in the proband...
  27. doi Dicer in Schwann cells is required for myelination and axonal integrity
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule ETH Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:6763-75. 2010
    ..At the molecular level, the promyelinating transcription factor Krox20 and several myelin proteins [including myelin associated glycoprotein (MAG) and PMP22] were strongly reduced in ..
  28. pmc Differential regulation of NAB corepressor genes in Schwann cells
    Rajini Srinivasan
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI, USA
    BMC Mol Biol 8:117. 2007
    Myelination of peripheral nerves by Schwann cells requires not only the Egr2/Krox-20 transactivator, but also the NGFI-A/Egr-binding (NAB) corepressors, which modulate activity of Egr2...
  29. pmc Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons
    Brian Yee Hong Lam
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 284:12562-71. 2009
    ..the IEG c-fos is unaffected by suppression of calcineurin activity, the plasticity-related genes Egr1/Zif268 and Egr2/Krox-20 are up-regulated, and genes encoding the orphan nuclear hormone receptors Nor1 and Nur77 are down-regulated...
  30. pmc Identifying significant genetic regulatory networks in the prostate cancer from microarray data based on transcription factor analysis and conditional independency
    Hsiang Yuan Yeh
    Department of Computer Science, National Tsing Hua University, Hsinchu 300, Taiwan
    BMC Med Genomics 2:70. 2009
    ....
  31. pmc Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C
    S D Crosby
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 89:4739-43. 1992
    ..related to the previously described early response genes, nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2, and EGR3...
  32. pmc Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator
    J Champagnat
    Centre de Recherche de Gif, UPR 2216 Neurobiologie Génétique et Intégrative, IFR 2118 Institut de Neurobiologie Alfred Fessard, CNRS, 91198 Gif sur Yvette, France
    Philos Trans R Soc Lond B Biol Sci 364:2469-76. 2009
    ..Inactivation of Krox20/Egr2 eliminates the pFRG activity, thereby causing life-threatening neonatal apnoeas alternating with respiration ..
  33. ncbi Binding of transcription factor Sp1 to GC box DNA revealed by footprinting analysis: different contact of three zinc fingers and sequence recognition mode
    J Kuwahara
    Institute for Chemical Research, Kyoto University, Japan
    Biochemistry 32:5994-6001. 1993
    ..These features are clearly distinct from those of Zif268 and Krox20, which are three-zinc-finger proteins closely related to Sp1.
  34. ncbi Neural crest patterning: autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control
    Julien Ghislain
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 130:941-53. 2003
    ..b>Krox20, a transcription factor gene that plays a critical role in the development of the segmented hindbrain, is ..
  35. pmc Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription
    Anna Maria Calella
    European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini, 00016 Monterotondo, Italy
    Neural Dev 2:4. 2007
    ....
  36. ncbi [Experimental identification of drugs with function of targeted up-regulating ID4 expression: bioinformatics-based prediction and preliminary validation]
    Bo Yang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 89:1714-6. 2009
    ..To screen new candidate molecular-targeted anti-leukemia compounds with potential functions of targeted up-regulating ID4 gene expression...
  37. pmc Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter
    N Koyano-Nakagawa
    Department of Molecular and Development Biology, Institute of Medical Science, University of Tokyo, Japan
    Mol Cell Biol 14:5099-107. 1994
    ..Two were identical to known transcription factors, EGR1 and EGR2, and the other clone, named DB1, encoded a novel protein of 516 amino acids with six zinc finger motifs...
  38. ncbi foxD5a, a Xenopus winged helix gene, maintains an immature neural ectoderm via transcriptional repression that is dependent on the C-terminal domain
    S A Sullivan
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Dev Biol 232:439-57. 2001
    ..plate appears to be maintained in an immature state because otx2 expression is expanded and expression of en2, Krox20, proneural genes (Xnrgn1, neuroD) and a neural differentiation gene (n-tubulin) is repressed in foxD5a-expressing ..
  39. ncbi Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve
    Takashi Saito
    Department of Physiology, Akita University School of Medicine, Akita 010 8543, Japan
    Neurosci Lett 414:35-40. 2007
    ..not only in Schwann cells, which express the Schwann cell marker S100beta and a zinc finger transcription factor Krox20 (a marker for myelin-forming Schwann cells), but also in Krox20-negative cells, which express glial fibrillary ..
  40. doi Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
    ..differences of six genes (calsequestrin, NNAT, neurogranin, secreted protein acidic and rich in cysteine (SPARC), EGR2, and MAOB) were confirmed by RT-PCR in 25 PCs...
  41. ncbi Identification and characterization of TRIP8 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:817-21. 2003
    ..Intra-species comparative genomics revealed that TRIP8-EGR2 locus at human chromosome 10q21...
  42. ncbi Adrenal transcription regulatory genes modulated by angiotensin II and their role in steroidogenesis
    Damian G Romero
    Division of Endocrinology, G V Sonny Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, USA
    Physiol Genomics 30:26-34. 2007
    ..BHLHB2, BTG2, and SALL1 decreased expression of both enzymes, whereas CITED2, EGR2, ELL2, FOS, FOSB, HDAC5, MAFF, MITF, NFIL3, NR4A1, NR4A2, NR4A3, PER1, and VDR increased expression for both ..
  43. doi Altered brain gene expression profiles associated with the pathogenesis of phenylketonuria in a mouse model
    Joo Won Park
    Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, South Korea
    Clin Chim Acta 401:90-9. 2009
    ..The resultant hyperphenylalaninemia causes mental retardation, seizure, and abnormalities in behavior and movement...
  44. ncbi Retinoic acid synthesis and hindbrain patterning in the mouse embryo
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
    Development 127:75-85. 2000
    ..Instead of being expressed in two alternate rhombomeres (r3 and r5), Krox20 is expressed in a single broad domain, correlating with an abnormal expansion of the r2-r3 marker Meis2...
  45. ncbi Dejerine-Sottas disease and hereditary demyelinating polyneuropathy of infancy
    Violaine Plante-Bordeneuve
    Department of Neurology, Centre Hospitalier Universitaire de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Muscle Nerve 26:608-21. 2002
    ..in the original study, and at least seven genes encoding the myelin proteins P0, PMP22, the transcriptional factor EGR2, and others have been implicated...
  46. pmc Novel mutants of NAB corepressors enhance activation by Egr transactivators
    J Svaren
    Division of Laboratory Medicine, Departments of Pathology and Internal Medicine, Campus Box 8118, 660 S Euclid Ave, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 17:6010-9. 1998
    ..binding corepressors NAB1 and NAB2 interact with a conserved domain (R1 domain) within the Egr1/NGFI-A and Egr2/Krox20 transactivators, and repress the transcription of Egr target promoters...
  47. ncbi Direct regulation of myelin protein zero expression by the Egr2 transactivator
    Scott E Leblanc
    Molecular and Cellular Pharmacology Program, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53705, USA
    J Biol Chem 281:5453-60. 2006
    ..within the first intron of the Mpz gene, which contains binding sites for the early growth response 2 (Egr2/Krox20) transcription factor, a critical regulator of peripheral nerve myelination...
  48. ncbi Differential expression of hoxa2a and hoxa2b genes during striped bass embryonic development
    Jean Luc Scemama
    Department of Biology, Howell Science Complex, East Carolina University, Greenville, NC 27858, USA
    Gene Expr Patterns 6:843-8. 2006
    ..uncharacterized paralogs group 2 Hox genes, striped bass hoxa2a and hoxa2b, and the developmental regulatory gene egr2. We demonstrate that both Hox genes are expressed in the rhombomeres of the developing hindbrain and the pharyngeal ..
  49. pmc Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10
    Scott E Leblanc
    University of Wisconsin Madison, WI 53706, USA
    Mol Cell Biol 27:3521-9. 2007
    Dominant mutations in the early growth response 2 (Egr2/Krox20) transactivator, a critical regulator of peripheral myelin development, have been associated with peripheral myelinopathies...
  50. ncbi Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy
    Sanjay N Rakhade
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 48:86-95. 2007
    ..We have recently identified a common group of genes induced in human epileptic foci, including EGR1, EGR2, c-fos, and MKP-3...
  51. pmc Induction of myelin protein zero by early growth response 2 through upstream and intragenic elements
    Sung Wook Jang
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 284:20111-20. 2009
    ..of the Mpz gene is controlled by two major transactivators that coordinate Schwann cell development: Egr2/Krox20 and Sox10...
  52. doi CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function
    Fanny Coulpier
    Plate forme Transcriptome and Developmental Biology Section, INSERM, Unité 1024, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8197, Institut de Biologie de l Ecole Normale Supérieure, 75230 Paris, France
    J Neurosci 30:5958-67. 2010
    ..We show that depletion of Schwann cells and boundary cap cells or inactivation of Krox20/Egr2, a master regulatory gene for myelination in Schwann cells, results in transgression of the CNS/PNS boundary ..
  53. pmc Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain
    A H Swirnoff
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 18:512-24. 1998
    ..the NGFI-A (Egr-1, Krox24, zif/268) family of immediate-early gene transcription factors, which includes NGFI-C, Krox20, and Egr3...
  54. ncbi Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 126:5171-9. 1999
    ..However, the most anterior neural gene that was expressed in the ectopic axis was Krox20 that marks parts of the hindbrain, but markers of the mid- and forebrain (Otx2 and En1) were not expressed...
  55. pmc A novel locus for autosomal recessive peripheral neuropathy in the EGR2 region on 10q23
    T Rogers
    Centre for Human Genetics, Edith Cowan University Joondalup Campus, Perth, WA 6027, Australia
    Am J Hum Genet 67:664-71. 2000
    ..branches of the large kindred detected linkage to the 10q22-q23 region containing the early growth response 2 gene (EGR2), a transcription factor with a key role in peripheral nerve myelination...
  56. ncbi Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms
    Zhu Chen
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Cell Metab 1:93-106. 2005
    b>Krox20 is a zinc finger-containing transcription factor that is abundantly expressed in adipose tissue. However, its role in fat cell differentiation has not been established...
  57. ncbi Krox20 is down-regulated following triazole in vitro embryonic exposure: a polycompetitor-based assay
    Valentina Massa
    Department of Biology, University of Milano, Milano, Italy
    Toxicol Lett 169:196-204. 2007
    ..Specification of hindbrain segments is regulated by retinoic acid and the hox code. Krox20 was chosen as molecular marker for its specific distribution in the anterior neural tube...
  58. doi Inhibition of BMPs by follistatin is required for FGF3 expression and segmental patterning of the hindbrain
    Karen Weisinger
    Koret School of Veterinary Medicine, Hebrew University, Faculty of Agriculture, Food and Environmental Quality Sciences, P O Box 12, Rehovot 76100, Israel
    Dev Biol 324:213-25. 2008
    ..FGF signaling is required in this network to upregulate the expression of the Krox20 and Kreisler segmentation genes, but little is known of how FGF gene expression is regulated in the hindbrain...
  59. ncbi Congenital hypomyelination neuropathy in a newborn infant: unusual cause of diaphragmatic and vocal cord paralyses
    J S Hahn
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Lucile Packard Children s Hospital at Stanford, Stanford, California, USA
    Pediatrics 108:E95. 2001
    ..DNA analysis for identification of previously characterized mutations in the genes MPZ, PMP22, and EGR2 was negative...
  60. ncbi Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood
    C Glorioso
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15261, USA
    Mol Psychiatry 11:633-48. 2006
    ..Furthermore, we observed expression alterations in genes encoding early-immediate genes (ARC, EGR1, EGR2, FOS, DUSP1, DUSP6) and critical cellular signaling systems (CDKN1c, CCND2, CAMK1g, RGS4)...
  61. pmc Active gene repression by the Egr2.NAB complex during peripheral nerve myelination
    Gennifer M Mager
    Molecular and Cellular Pharmacology Training Program, Department of Comparative Biosciences, Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    J Biol Chem 283:18187-97. 2008
    The Egr2/Krox20 transactivator is required for activation of many myelin-associated genes during peripheral nerve myelination by Schwann cells...
  62. pmc Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation
    Shih Chu Kao
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Science 323:651-4. 2009
    ..of NFAT protein complexes shows that Sox10 is an NFAT nuclear partner and synergizes with NFATc4 to activate Krox20, which regulates genes necessary for myelination...
  63. pmc Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts
    Zhaoliang Fei
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4264, USA
    J Biol Chem 286:27761-8. 2011
    ..There was an increase in expression of early stage adipogenesis genes such as Krox20, KLF5, C/EBPβ, C/EBPδ, and late stage adipogenesis regulators KLF15, C/EBPα, PPARγ, and aP2...
  64. pmc A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales
    S K Service
    Center for Neurobehavioral Genetics, University of California, Los Angeles, CA, USA
    Transl Psychiatry 2:e116. 2012
    ..Item response theory methodology may be a way to incorporate data from cohorts assessed with multiple personality instruments, and might be a method by which a large sample of a more refined phenotype could be acquired...
  65. doi Autosomal recessive Charcot-Marie-Tooth disease: from genes to phenotypes
    Meriem Tazir
    Service de Neurologie, University Hospital Mustapha Bacha, Alger, Algeria
    J Peripher Nerv Syst 18:113-29. 2013
    ..with autosomal recessive inheritance allowed the identification of many genes such as GDAP1, MTMR2, SBF2, NDRG1, EGR2, SH3TC2, PRX, FGD4, and FIG4, implicated in demyelinating forms (ARCMT1 or CMT4), and LMNA, MED25, HINT1, GDAP1, ..
  66. pmc Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning
    Yassine X Bouchoucha
    1 Ecole Normale Supérieure, IBENS, Paris, France 2 INSERM, U1024, Paris, France 3 CNRS, UMR 8197, Paris, France
    Mol Syst Biol 9:690. 2013
    ..in mice, we demonstrate that a direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation...
  67. doi The transcriptional programs of iNKT cells
    Edy Y Kim
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 15 Francis Street, Boston, MA 02115, United States Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith Building, 5th Floor, 1 Jimmy Fund Way, Boston, MA 02115, United States Electronic address
    Semin Immunol 27:26-32. 2015
    ..The transcription factors EGR2 and PLZF (and microRNA like miR-150) are key regulators of the iNKT cell transcriptome during development...
  68. pmc Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair
    Susanne Quintes
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Nat Neurosci 19:1050-9. 2016
    ..require the serial expression of transcriptional activators, such as Sox10, Oct6 (also called Scip or Pou3f1) and Krox20 (also called Egr2)...
  69. ncbi A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1
    T Yoshihara
    Department of Neurology, Nagoya University School of Medicine, Nagoya 466, Japan
    J Neurol Sci 184:149-53. 2001
    A novel mutation (Arg381Cys) in the second zinc-finger domain of early growth response 2 (EGR2) was identified in a late-onset Charcot--Marie--Tooth disease type 1 (CMT1) patient...
  70. ncbi Segment-specific expression of connexin31 in the embryonic hindbrain is regulated by Krox20
    Stefan Jungbluth
    Neurobiologie Genetique et Integrative, Institut de Neurobiologie Alfred Fessard, CNRS, Gif sur Yvette, France
    Dev Dyn 223:544-51. 2002
    ..corresponded to r3 and r5 and that Cx31 expression in r3 and r5 was controlled by the transcription factor Krox20. In contrast, expression of Cx43 and Cx36 started later (from E9.5 and E10...
  71. ncbi Analysis of hindbrain patterning defects caused by the kreisler(enu) mutation reveals multiple roles of Kreisler in hindbrain segmentation
    Virginia S Sadl
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 227:134-42. 2003
    ..These analyses demonstrate that Kreisler is required for maintenance and expansion but not initiation of the Krox20 expressing r5 domain...
  72. ncbi The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20
    Anne Lynn Gillian
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 279:9056-63. 2004
    The early growth response 2 (Egr2/Krox-20) transcription factor is essential for myelination of the peripheral nervous system and segmentation of the vertebrate hindbrain...
  73. ncbi Profiling of genes associated with transcriptional responses in mouse hippocampus after transient forebrain ischemia using high-density oligonucleotide DNA array
    Toshihito Nagata
    Department of Advanced Medicine, Nihon University, School of Medicine, 30 1 Oyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    Brain Res Mol Brain Res 121:1-11. 2004
    ..of expression of several kinds of biological pathways, regulating transcription (Bhlhb2, Jun, c-fos, Egr1, Egr2, Fosb, Junb, Ifrd1, Neurod6), the cell cycle (c-fos, Fosb, Jun, Junb, Dusp1), stress response (Dusp1, Dnajb1, ..
  74. ncbi Connexin 32 promoter P2 mutations: a mechanism of peripheral nerve dysfunction
    Henry Houlden
    Department of Molecular Neurosciences, Institute of Neurology, Queen Square, London, UK
    Ann Neurol 56:730-4. 2004
    ..These data suggest that interaction between the Cx32 P2 promoter, SOX10, and EGR2 highlight a mechanism of peripheral nerve dysfunction.
  75. ncbi Ontogeny of central rhythm generation in chicks and rodents
    F Chatonnet
    UPR 2216, Neurobiologie Genetique et Integrative, Institut Fédératif de Neurobiologie Alfred Fessard, C N R S 1, Avenue de la Terrasse, Gif sur Yvette, 91198 Cedex, France
    Respir Physiol Neurobiol 154:37-46. 2006
    ..Neonatal respiratory abnormalities in Krox20(-/-), Hoxa1(-/-) and kreisler mutant mice indicate the vital role of a para-facial (Krox20-dependent, rhombomere 4-..
  76. ncbi Transdifferentiated mesenchymal stem cells as alternative therapy in supporting nerve regeneration and myelination
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
    Cell Mol Neurobiol 26:1235-52. 2006
    ..They are multipotent stem cells that differentiate into cells of the mesodermal lineage like bone, cartilage, fat, and muscle. Although adult, their differentiation potential is remarkable, and they are able to transdifferentiate...
  77. doi Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway
    Elizabeth W Bradley
    Department Biochemistry and Molecular Biology
    J Biol Chem 283:8055-64. 2008
    ..M-CSF activates MEK/ERK and induces MEK-dependent expression of the immediate early gene Egr2. Inhibition of either MEK1/2 or inhibition of Egr2 increases osteoclast apoptosis...
  78. pmc Distinct functions of egr gene family members in cognitive processes
    Roseline Poirier
    Univ Paris Sud, Laboratoire de Neurobiologie de l Apprentissage, de la Mémoire et de la Communication Orsay, France
    Front Neurosci 2:47-55. 2008
    ..We also review our own recent findings from newly generated forebrain-specific conditional Egr2 mutant mice, which revealed that Egr2, as opposed to Egr1 and Egr3, is dispensable for several forms of learning ..
  79. doi Protocadherin-19 is essential for early steps in brain morphogenesis
    Michelle R Emond
    Center for Molecular Neurobiology and Department of Neuroscience, 115 Rightmire Hall, Ohio State University, Columbus, OH 43210, USA
    Dev Biol 334:72-83. 2009
    ..1 and krox20. Characterization of embryos early in development by in vivo 2-photon timelapse microscopy reveals that the ..
  80. pmc Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation
    Denis Bernot
    INSERM, U626, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, Marseilles 13385 Cedex 5, France
    J Biol Chem 285:6508-14. 2010
    ..the early and obligate key inductors of adipogenesis Krüppel-like factor 4 (Klf4), early growth response 2 (Egr2/Krox20), and CAAT/enhancer-binding protein beta (C/EBPbeta)...
  81. pmc Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass
    Yankel Gabet
    Department of Biochemistry and Molecular Biology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    Blood 116:3964-71. 2010
    b>Krox20/EGR2, one of the 4 early growth response genes, is a highly conserved transcription factor implicated in hindbrain development, peripheral nerve myelination, tumor suppression, and monocyte/macrophage cell fate determination...
  82. pmc Peripheral nerve pathology, including aberrant Schwann cell differentiation, is ameliorated by doxycycline in a laminin-α2-deficient mouse model of congenital muscular dystrophy
    Sachiko Homma
    Neuromuscular Biology and Disease Group, Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Hum Mol Genet 20:2662-72. 2011
    ..significant decrease in both immature/non-myelinating [glial fibrillary acidic protein (GFAP)(+)] and myelinating (Krox20+) Schwann cells...
  83. doi A new horizon into the pathobiology, etiology and treatment of migraine
    Kundan Singh Dhillon
    Punjab Agricultural University, Ferozpur Road, Ludhiana, 141004 Punjab, India
    Med Hypotheses 77:147-51. 2011
    ..Furthermore, zinc is an essential component of Zn-fingers (Krox20 and Krox24) which play a pivotal role in the differentiation of Schwann cells-the mainstay for the myelination/..
  84. pmc Gpr126 is essential for peripheral nerve development and myelination in mammals
    Kelly R Monk
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 138:2673-80. 2011
    ..peripheral neuropathy in mice, and expression of differentiated Schwann cell markers, including Pou3f1, Egr2, myelin protein zero and myelin basic protein, is reduced...
  85. pmc Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development
    Michael A Balamotis
    Lawrence Berkeley National Laboratory, University of California, Berkeley, California, USA
    Mol Cell Biol 32:333-47. 2012
    ..that in the cerebral cortex, Satb1 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc, and Bdnf) and other key neuronal genes, many of which have been implicated in synaptic plasticity...
  86. doi Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells
    Shan Shan Wang
    Key Laboratory of Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, PR China
    Int J Biochem Cell Biol 45:1825-32. 2013
    Early growth response 2 (Egr2) is a zinc-finger transcription factor that acts as an important modulator of a variety of physiological processes, such as cell differentiation, proliferation and apoptosis...
  87. pmc L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression
    Annalisa Zuccotti
    Molecular Physiology of Hearing, Hearing Research Center Tübingen, Department of Otolaryngology, University of Tübingen Tübingen, Germany
    Front Mol Neurosci 6:20. 2013
    ..In the second mouse line, the Egr2 promoter was used for deleting CaV1.2 (CaV1.2(Egr2)) in auditory brainstem nuclei...
  88. pmc Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation
    Fabrice Prin
    Division of Physiology and Metabolism, Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Development 141:1492-502. 2014
    ..However, Krox20, a key segmentation factor expressed in odd rhombomeres (r3 and r5), can largely override Hox proteins at the ..
  89. pmc Gene delivery in mouse auditory brainstem and hindbrain using in utero electroporation
    Laurence S David
    The Hospital for Sick Children Research Institute and Department of Physiology, Program in Neurosciences and Mental Health, University of Toronto, 555 University Ave, Toronto M5G 1X8, ON, Canada
    Mol Brain 7:51. 2014
    ..electroporation technique which involves efficient delivery of hindbrain-specific enhancer/promoter construct, Krox20 into the third ventricle of live mouse embryo to investigate green fluorescent protein (GFP) expression pattern in ..
  90. doi WWP2: a multifunctional ubiquitin ligase gene
    Wei Chen
    Department of Pathophysiology, Sichuan North Medical College, Nanchong, 637100, People s Republic of China
    Pathol Oncol Res 20:799-803. 2014
    ..proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so. Hereafter, we reviewed the recent research process about the function of WWP2.
  91. doi Cytokine-induced sleep: Neurons respond to TNF with production of chemokines and increased expression of Homer1a in vitro
    Maureen Karrer
    Institute of Experimental Immunology, University of Zurich, Winterthurerstr 190, 8057 Zurich, Switzerland
    Brain Behav Immun 47:186-92. 2015
    ..increased the expression of Homer1a and IL-1β profoundly enhanced the expression of Early growth response 2 (Egr2)...
  92. pmc Dynamic regulation of Schwann cell enhancers after peripheral nerve injury
    Holly A Hung
    From the Waisman Center, Cellular and Molecular Pathology Graduate Program, and
    J Biol Chem 290:6937-50. 2015
    ..that lose H3K27ac after nerve injury are enriched for binding sites of the Sox10 and early growth response 2 (Egr2/Krox20) transcription factors, which are critical determinants of Schwann cell differentiation...
  93. doi Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells
    Ewa Kozela
    The Dr Miriam and Sheldon G Adelson Center for the Biology of Addictive Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neuroinflammation 12:273. 2015
    ..However, the mechanisms of CBD anti-inflammatory activities are unclear...
  94. pmc The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
    Deniz Gökbuget
    Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Otto Stern Weg 7, 8093 Zurich, Switzerland
    Nat Commun 6:8584. 2015
    ..analyses revealed that let-7 miRNAs promote expression of the myelination-driving master transcription factor Krox20 (also known as Egr2) through suppression of myelination inhibitory Notch signalling...
  95. doi The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair
    Sheridan L Roberts
    Plymouth University Peninsula School of Medicine and Dentistry, Derriford, Plymouth, Devon, UK
    J Neurochem . 2016
    ..Transcription factors such as Sox10, octamer-binding transcription factor 6 (Oct6) and Krox20 form a positive regulatory network, whereas negative regulators such as cJun and Sox2 oppose myelination in ..
  96. ncbi Early growth response transcriptional regulators are dispensable for macrophage differentiation
    John H Carter
    Department of Pathology, Northwestern University, 330 E Chicago Avenue, Chicago, IL 60611, USA
    J Immunol 178:3038-47. 2007
    ..to be induced in myeloid cells when they were differentiated into macrophages by treatment with M-CSF, whereas Egr2 was minimally induced and Egr4 was not detected...
  97. ncbi Transcription factors NFAT2 and Egr1 cooperatively regulate the maturation of T-lymphoma in vitro
    E K Koltsova
    Moscow State Medical Stomatological University, Moscow 127473, Russia
    Biochemistry (Mosc) 72:954-61. 2007
    ..Egr1 and NFAT2 cooperate in regulation of the early stages of T-lymphocyte development, whereas the related factors Egr2 and Egr3 do not cooperate with NFAT2...
  98. pmc Boundary cap cells are peripheral nervous system stem cells that can be redirected into central nervous system lineages
    Violetta Zujovic
    Centre de Recherche de l Institut du Cerveau et de Moelle épinière, Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S975, 75013 Paris, France
    Proc Natl Acad Sci U S A 108:10714-9. 2011
    Boundary cap cells (BC), which express the transcription factor Krox20, participate in the formation of the boundary between the central nervous system and the peripheral nervous system...
  99. doi Fluctuation of Rac1 activity is associated with the phenotypic and transcriptional heterogeneity of glioma cells
    Hiroko Yukinaga
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Sci 127:1805-15. 2014
    ..Among the transcription factors upregulated in Rac1(high) cells, Egr2 was found to positively regulate expression of the four membrane-related invasion-associated genes...
  100. pmc CAMKII-conditional deletion of histone deacetylase 2 potentiates acute methamphetamine-induced expression of immediate early genes in the mouse nucleus accumbens
    Oscar V Torres
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224
    Sci Rep 5:13396. 2015
    ..Interestingly, HDAC2KO mice displayed greater METH-induced increases in Egr1 and Egr2 mRNA levels measured at one hour post-injection...
  101. doi Fasciola hepatica tegumental antigens induce anergic-like T cells via dendritic cells in a mannose receptor-dependent manner
    Allison Aldridge
    Fundamental and Translational Immunology Group, School of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland
    Eur J Immunol 46:1180-92. 2016
    ..hepatica infection and after injection with FhTeg. Markers of T-cell anergy, such as GRAIL, EGR2, ICOS, and ITCH, are enhanced amongst CD4(+) T-cell populations during infection and following FhTeg injection...

Research Grants24

  1. Genetic and Functional Profiles of Serotonergic Neuron Subtypes
    Rachael D Brust; Fiscal Year: 2013
    ..resides selectively in the 5-HT neuron lineage defined by developmental expression of the transcription factor Krox20 and originating from hindbrain rhombomere 5 (r5)...
  2. William S Talbot; Fiscal Year: 2016
    ..In addition, we will test the hypothesis that this new transmembrane protein triggers myelination by activating krox20 in Schwann cells...
  3. Exploring the Role of Egr2 in the Alternative Activation of Macrophages
    Achsah D Keegan; Fiscal Year: 2013
    ..Furthermore, using gene expression arrays and a novel Egr2-EGFP reporter mouse, we found that IL-4 rapidly and potently induced the expression of the transcription factor ..
  4. Regulation of Myelination by Egr2/Nab Protein Complexes
    Jeffrey Milbrandt; Fiscal Year: 2009
    The discovery that Egr2-deficient mice have hypomyelinated peripheral nerves led to the realization that EGR2 is an essential regulator of the Schwann cell myelination program and, moreover, to the identification of EGR2 mutations in ..
  5. KROX 20 AND BONE MASS
    Baruch Frenkel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Krox20 and Bone Mass. We propose to delineate the role of the transcription factor Krox20 in the regulation of osteoblast function and bone mass control...
  6. JONATHAN D CHERNOFF; Fiscal Year: 2016
    ..if loss of Pak function reverses the activation of MAPK and cytoskeletal alterations in vitro;and 3) We will cross Krox20-cre/Nf1flox/- mice, which develop malignant peripheral nerve sheath tumors, with Pak1 knock out mice, or ..
  7. Thomas F Gajewski; Fiscal Year: 2016
    ..knockout studies, gene expression profiling and ChIP-Seq experiments, we have identified the transcription factor EGR2 as a central regulator of expression of these negative regulatory factors in T cell anergy...
  8. Regulation of Monocyte and Granulocyte Lineage Specification
    Alan D Friedman; Fiscal Year: 2013
    ..Microarray studies using an inducible cell line, combined with ChIP data, suggest that the EGR2 promoter is an additional C/EBPa:AP-1 genetic target. Egr-2, like elevated PU.1, favors monopoiesis...
  9. CMT Peripheral Neuropathy: IV. Genes and Pathogenesis
    JAMES LUPSKI; Fiscal Year: 2005
    ..nerve structure/function and maintenance; (ii) genes that are downstream targets of the transcription factor EGR2 are important candidates for inherited peripheral nerve disease; (iii) structural features of the human genome may ..
  10. Zinc finger nuclease induced knockout and knock-in models in zebrafish
    Meera T Saxena; Fiscal Year: 2011
    ..have created ZFN-based knock-ins in other systems, we be employed to introduce a fluorescent reporter into the krox20 locus...
  11. DGK in T Cell Regulation and Tolerance
    Thomas F Gajewski; Fiscal Year: 2010
    ..be analyzed functionally using adenoviral vectors and CAR the second specific aim, the functional adenoviruses for EGR2 expression, and a Cre adenovirus for conditional deletion of EGR2 in employed using the CAR Tg system...
  12. ERK Mitogen Activated Protein Kinases in Skeletogenesis
    Edward M Greenfield; Fiscal Year: 2012
    ..We hypothesize that 1) Krox20 expression is regulated by ERK1/ERK2 through its MAPK response element via DNA binding complex containing direct ..
  13. SEEKING THE YEAST SPARKING STEROL
    Martin Bard; Fiscal Year: 1991
    ..This proposal seeks to clone Candida ERG genes (EGR2,3,6) and by gene-disruption and allele replacement DNA technology ascertain whether bulk membrane requirements in ..
  14. Rajeshwar B Awatramani; Fiscal Year: 2014
    ..transition, maintain the expression of Sox2, and lack the SC master regulator gene Egr2 (Krox20)...
  15. FUNCTION OF IMMEDIATE EARLY GENES IN THE NERVOUS SYSTEM
    Warren Tourtellotte; Fiscal Year: 2001
    ..known transcription factors that include egr1 (also known as NGFI-A, zif/268, and Krox24), egr2 (also known as Krox20), egr3 and egr4 (also known as NGFI-C and pAT133)...
  16. MECHANISMS OF ISLET TRANSPLANTATION TOLERANCE
    Aldo Rossini; Fiscal Year: 2007
    ..or down-regulated upon induction of T cell anergy and will focus on two exciting candidate I genes, PAC-1 and Egr2. Project #4 will test the hypothesis that T cells recognizing their specific antigen together with a death-inducing ..
  17. The role of pFRG neurons in the respiratory network.
    SERAPIO BACA; Fiscal Year: 2009
    ..these experiments, we will provide further quantification of the breathing rhythm and pattern in transgenic mice (Krox20-/-) that have pFRG/RTN pathology (Aim2B)...
  18. NHLBI MINORITY SCHOOL DEVELOPMENT AWARD
    Steven Edwards; Fiscal Year: 1993
    Egr-l, EGR2, and EGR3 are early response genes, meaning that they are rapidly and transiently stimulated by mitogens, growth factors, and a variety of other stimuli...
  19. INTERACTION OF LEAD WITH ZINC FINGER PROTEINS
    Nasser Zawia; Fiscal Year: 2002
    ..are to study the effects of lead exposure on the DNA binding properties of zinc finger proteins (zif268, SP1, and krox20) and to examine if their functional capacity of gene activation/deactivation is impaired by lead...
  20. MOLECULAR BASIS OF HEREDITARY NEURALGIC AMYOTROPHY
    PHILLIP CHANCE; Fiscal Year: 2008
    ..Moreover, characterization of the HNA gene may have broader pathophysiological and therapeutic implications for more common idiopathic forms of brachial neuropathy. [unreadable] [unreadable]..
  21. Insulin Signaling in the Anterior Pituitary
    MARK LAWSON; Fiscal Year: 2006
    ....
  22. Mechanisms of Response to GnRH Receptor Signaling
    MARK LAWSON; Fiscal Year: 2005
    ..Isolation of actively translated and total mRNA from treated and control cells will allow identification and quantification of global changes in gene expression. ..
  23. MOLECULAR MECHANISMS MEDIATING NERVE MUSCLE INTERACTIONS
    Warren G Tourtellotte; Fiscal Year: 2010
    ....
  24. Identification and characterization of the ALS4 gene
    PHILLIP CHANCE; Fiscal Year: 2006
    ..Specific Aim (5) is to develop an animal model of ALS4 by introducing an identified disease-causing mutation into the germline of the mouse by employing either transgenesis or gene targeting. ..

Patents1

  1. T cell activating gene
    Patent Number: WO2004058805-A2; Date:2004-07-15