EGF

Summary

Gene Symbol: EGF
Description: epidermal growth factor
Alias: HOMG4, URG, pro-epidermal growth factor, beta-urogastrone
Species: human

Top Publications

  1. doi EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth
    Frédéric Bouchard
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, QC
    Blood 116:759-66. 2010
  2. doi Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1
    Wei Yi
    Department of Radiation Sciences, Oncology, Umea University, SE 90187 Umea, Sweden
    Exp Cell Res 317:504-12. 2011
  3. ncbi Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium
    Thomas Pusl
    Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Biol Chem 277:27517-27. 2002
  4. pmc Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling
    Ning Wang
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 281:21878-83. 2006
  5. doi EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332
    Petra Richter
    Institute of Pathology, University Hospital Jena, Jena, Germany
    J Oral Pathol Med 40:46-54. 2011
  6. doi Effects of combined epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1 on human oocyte maturation and early fertilized and cloned embryo development
    Yang Yu
    Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, No 49 Huayuan North Road, Haidian District, 100191 Beijing, The People s Republic of China
    Hum Reprod 27:2146-59. 2012
  7. pmc IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin
    Jamie McIntosh
    School of Clinical Sciences, IGFs and Metabolic Endocrinology Group, Learning and Research Building, 2nd Floor, University of Bristol, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Biol Chem 285:38788-800. 2010
  8. pmc Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
    M Holgado-Madruga
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Bluemle Life Science Building 1002, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 94:12419-24. 1997
  9. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
  10. pmc A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
    G A Rodrigues
    Department of Pharmacology and Skirball Institute, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 20:1448-59. 2000

Research Grants

  1. SIGNALING MECHANISMS IN EPIDERMAL GROWTH FACTOR ACTION
    Tarun Patel; Fiscal Year: 2002
  2. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
  3. c-Src/EGF Receptors Interactions and Therapeutic Resistance in Breast Cancer
    Sarah J Parsons; Fiscal Year: 2010
  4. Alessio Fasano; Fiscal Year: 2015
  5. Molecular Mechanisms of EGF Signaling &Iressa/Tarceva Inhibition in NSCLC
    Karen S Anderson; Fiscal Year: 2012
  6. Hyaluronan in Epidermal Injury Responses
    Edward Maytin; Fiscal Year: 2009
  7. Biomolecular Analysis using Liquid Crystals
    Nicholas L Abbott; Fiscal Year: 2013
  8. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
  9. Michael H Nathanson; Fiscal Year: 2014
  10. Synthetic cannabinoids as novel therapeutic strategies against non-small cell lun
    Ramesh K Ganju; Fiscal Year: 2012

Detail Information

Publications303 found, 100 shown here

  1. doi EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth
    Frédéric Bouchard
    Institut National de la Recherche Scientifique Institut Armand Frappier, Universite du Quebec, Laval, QC
    Blood 116:759-66. 2010
    ..that EGR-1 expression is induced in stromal cells after contact with lymphoma cells via epidermal growth factor (EGF)...
  2. doi Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1
    Wei Yi
    Department of Radiation Sciences, Oncology, Umea University, SE 90187 Umea, Sweden
    Exp Cell Res 317:504-12. 2011
    ..has been demonstrated to regulate various oncogenic receptor tyrosine kinases, including epidermal growth factor (EGF) receptor (EGFR), by cell-autonomous mechanisms...
  3. ncbi Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium
    Thomas Pusl
    Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Biol Chem 277:27517-27. 2002
    ..Here we investigated the role of nuclear and cytosolic Ca(2+) signals in epidermal growth factor (EGF)-induced transactivation of the ternary complex factor Elk-1 using a GAL4-Elk-1 construct...
  4. pmc Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling
    Ning Wang
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 281:21878-83. 2006
    ..The interaction of SHP-1 and SHP-2 may be responsible for previously unexpected novel regulatory mechanism of cell signaling by tyrosine phosphatases...
  5. doi EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332
    Petra Richter
    Institute of Pathology, University Hospital Jena, Jena, Germany
    J Oral Pathol Med 40:46-54. 2011
    ..expression in a cell culture model of transforming growth factor beta-1 (TGFβ1)/epithelial growth factor (EGF) long time co-stimulation...
  6. doi Effects of combined epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1 on human oocyte maturation and early fertilized and cloned embryo development
    Yang Yu
    Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, No 49 Huayuan North Road, Haidian District, 100191 Beijing, The People s Republic of China
    Hum Reprod 27:2146-59. 2012
    ..The purpose of this study was to evaluate the effects of multiple growth factors [epidermal growth factor (EGF), brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1)] on human oocyte maturation, ..
  7. pmc IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin
    Jamie McIntosh
    School of Clinical Sciences, IGFs and Metabolic Endocrinology Group, Learning and Research Building, 2nd Floor, University of Bristol, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Biol Chem 285:38788-800. 2010
    ..with remodeling of the extracellular matrix, often involving a switch from estrogen dependence to a dependence on EGF receptor (EGFR)/HER-2 and is accompanied by increased expression of the main binding protein for insulin-like ..
  8. pmc Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
    M Holgado-Madruga
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Bluemle Life Science Building 1002, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 94:12419-24. 1997
    ..Hence, Gab1 has a major role in connecting TrkA with PI 3-kinase activation and for the promotion of cell survival by NGF...
  9. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
    ..These findings, together with other observations, suggest that MSK1 may mediate the growth-factor and stress-induced activation of CREB...
  10. pmc A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
    G A Rodrigues
    Department of Pharmacology and Skirball Institute, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 20:1448-59. 2000
    ..To determine the role of Gab1 in signaling via the epidermal growth factor (EGF) receptor (EGFR) we tested the ability of Gab1 to associate with and modulate signaling by this receptor...
  11. pmc 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase
    Dong Eun Lee
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:21458-66. 2010
    ..in vivo studies have shown that isoflavones exhibit anti-proliferative activity against epidermal growth factor (EGF) receptor-positive malignancies of the breast, colon, skin, and prostate...
  12. doi Migration induced by epidermal and hepatocyte growth factors in oral squamous carcinoma cells in vitro: role of MEK/ERK, p38 and PI-3 kinase/Akt
    Ingvild J Brusevold
    Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    J Oral Pathol Med 41:547-58. 2012
    ..We have investigated signalling pathways involved in cell migration induced by epidermal growth factor (EGF) and hepatocyte growth factor (HGF) in OSCC cells and examined the effects of various experimental and clinically ..
  13. ncbi SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism
    Takao Toyoda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Biochem Biophys Res Commun 360:715-20. 2007
    ..Epidermal growth factor (EGF) is detected in several regions of the developing and adult brain, where, it enhances the differentiation, ..
  14. pmc Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma
    Kwang Yu Chang
    National Institute of Cancer Research, National Health Research Institutes, Tainan 701, Taiwan
    J Biol Chem 284:9908-16. 2009
    ..in tumor growth under normoxic conditions, specifically when cells are treated with epidermal growth factor (EGF), which is known to affect the gene expression of tumor growth-related protein COX-2 (cyclooxygenase-2)...
  15. pmc Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells
    Zekuan Xu
    Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    BMC Cancer 10:161. 2010
    ..The aim of this study was to investigate the effect of epidermal growth factor on the expression of HCCR in pancreatic cancer cells, and to explore if PI3K/Akt/mTOR signaling pathway mediated this expression...
  16. doi Pattern of distribution of IGF-1 and EGF in pancreatic islets of type 2 diabetic patients
    Suhail Al-Salam
    Department of Pathology, United Arab Emirates University, Al Ain, United Arab Emirates
    Islets 1:102-5. 2009
    Growth factors such as insulin growth factor-1 (IGF-1) and epidermal growth factor (EGF) play important roles in the regulation of cell metabolism in response to different internal as well as external stimuli...
  17. ncbi Association between EGF, TGF-{beta}1, TNF-{alpha} gene polymorphisms and cancer of the pancreatic head
    Guo yang Wu
    Department of General Surgery, Zhongshan Hospital, Xiamen University, Xiamen, PR China
    Anticancer Res 30:5257-61. 2010
    To date, EGF 61*A/G, TGF-β1 -509*T/C and TNF-α -308*A/G gene polymorphisms have been not been analysed in pancreatic carcinoma...
  18. doi Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstruction
    Fabio Bartoli
    Division of Pediatric Surgery, University of Foggia, Foggia, Italy
    J Pediatr Surg 46:530-6. 2011
    We demonstrated down-regulation of epidermal growth factor (EGF) and up-regulation of monocyte chemotactic protein-1 (MCP-1) in the renal parenchyma in children who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO)...
  19. ncbi Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis
    Hervé Le Stunff
    Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Biol Chem 279:34290-7. 2004
    ..Surprisingly, down-regulation of SPP-1 enhanced migration toward epidermal growth factor (EGF); conversely, overexpression of SPP-1, which is localized in the endoplasmic reticulum, attenuated migration toward ..
  20. ncbi Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia ind
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, 900 Veteran Avenue, Los Angeles, California 90095, USA
    J Biol Chem 280:22473-81. 2005
    ..Here we show for the first time that activation of the EGFR by EGF increases CXCR4 expression and the migratory capacity of NSCLC cells...
  21. ncbi ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase
    Cheng Fang Yu
    Department of Internal Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 277:19382-8. 2002
    We have examined the ability of epidermal growth factor (EGF)-stimulated ERK activation to regulate Grb2-associated binder-1 (Gab1)/phosphatidylinositol 3-kinase (PI3K) interactions...
  22. ncbi Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD
    Konduru S R Sastry
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 281:20891-901. 2006
    ..Taken together, these results identify BAD as a convergence point of several antiapoptotic signaling pathways in prostate cells...
  23. pmc ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells
    Pierre Luc Boulay
    Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 283:36425-34. 2008
    ..These results uncover a novel molecular mechanism by which ARF1 regulates breast cancer cell growth and invasion during cancer progression...
  24. ncbi Critical role of aquaporin-3 in the human epidermal growth factor-induced migration and proliferation in the human gastric adenocarcinoma cells
    Yiming Huang
    Division of Gastrointestinal Surgery, Department of General Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    Cancer Biol Ther 9:1000-7. 2010
    ..Aquaporins (AQPs) are expressed in many different tumor cell types in human. New evidence for the involvement of AQPs in cell migration and proliferation adds AQPs to an expanding list of effectors in tumor biology...
  25. ncbi Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells
    Isabelle M Berquin
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    Oncogene 24:3177-86. 2005
    ..by which EGFR becomes activated in breast cancer, we screened a cDNA expression library for genes that mediate EGF-independent proliferation of human mammary epithelial cells (HMECs)...
  26. pmc Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
    Kathryn M Geraghty
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 407:231-41. 2007
    ..to 14-3-3 isoforms in HEK (human embryonic kidney)-293 cells was induced by IGF-1 (insulin-like growth factor-1), EGF (epidermal growth factor), PMA and, to a lesser extent, AICAR (5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside)...
  27. ncbi FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium
    Giannoula Soufla
    Department of Virology, Medical School, University of Crete, PO Box 1527, Heraklion 71003, Crete, Greece
    Cancer Lett 259:146-55. 2008
    Epidermal and insulin-like growth factors (EGF, IGFs) act as mitogens promoting endothelial cell proliferation and differentiation. Accumulating evidence for interactions between EGF and IGF signaling pathways has been reported...
  28. pmc Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization
    G I Bell
    Nucleic Acids Res 14:8427-46. 1986
    Complementary DNA clones encoding the human kidney epidermal growth factor (EGF) precursor have been isolated and sequenced...
  29. pmc A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling
    Hadassa Waterman
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    EMBO J 21:303-13. 2002
    ..here we report that defective Tyr1045 of EGFR, an inducible c-Cbl docking site, enhances the mitogenic response to EGF. Signaling potentiation is due to accelerated recycling of the mutant receptor and a concomitant defect in ligand-..
  30. ncbi Association between functional polymorphism in EGF gene and malignant melanoma
    Majid Shahbazi
    Immunology Research Group, School of Biological Sciences, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Lancet 359:397-401. 2002
    ..of its role in mitogenesis, which is especially relevant to wound healing, tumorigenesis, and proliferation of epidermal tissues, epidermal growth factor (EGF) is an attractive candidate in which to look for genetic polymorphisms.
  31. ncbi Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients
    T Futamura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    Mol Psychiatry 7:673-82. 2002
    Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic ..
  32. ncbi Association of EGF polymorphism with schizophrenia in Finnish men
    Sami Anttila
    University of Tampere, Medical School, Finland
    Neuroreport 15:1215-8. 2004
    Some recent data suggest that epidermal growth factor (EGF) protein levels are altered in the brain of schizophrenic patients. In addition, a novel polymorphism of the EGF gene is associated with enhanced production of EGF in vitro...
  33. ncbi No association of EGF polymorphism with schizophrenia in a Japanese population
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Neuroreport 16:403-5. 2005
    Epidermal growth factor (EGF) signal regulates the development of dopaminergic neurons and monoamine metabolism. It is suggested that EGF protein levels are decreased in the brain and blood of patients with schizophrenia...
  34. ncbi Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells
    Lidiya Orlichenko
    Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 281:4570-9. 2006
    ..In this study we report that stimulation of epithelial cells with epithelial growth factor (EGF) results in a profound increase in the number of caveolar structures at the plasma membrane...
  35. ncbi Association between functional EGF+61 polymorphism and glioma risk
    Bruno Marques Costa
    Life and Health Sciences Research Institute ICVS, School of Health Sciences and Department of Production and Systems Engineering, University of Minho, Braga, Portugal
    Clin Cancer Res 13:2621-6. 2007
    Epidermal growth factor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness...
  36. ncbi Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer
    Meenu Jain
    Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Cancer Biol Ther 6:1553-8. 2007
    The study aimed at investigating whether genetic polymorphisms in BCL2, FAS, CCND1, EGF and EGFR genes influence the outcome of patients of esophageal squamous cell cancer treated with radiotherapy, with or without chemotherapy...
  37. pmc A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome
    Michael Lanuti
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Cancer Res 14:3216-22. 2008
    The epidermal growth factor (EGF) pathway is important in esophageal adenocarcinoma (EAC) tumorigenesis...
  38. pmc Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases
    Heather L LaMarca
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Hum Reprod 23:1733-41. 2008
    ..Evidence suggests that the potent mitogen epidermal growth factor (EGF) regulates cytotrophoblast (CTB) differentiation and invasion during early pregnancy.
  39. ncbi Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer
    Rohit Upadhyay
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Oncol Res 17:167-74. 2008
    Genetic polymorphisms in EGFR 497Arg>Lys and EGF +61A>G genes influence cell cycle progression, apoptosis, angiogenesis, and metastasis...
  40. ncbi No association between EGF +61 A/G polymorphism and increased risk of glioma
    Xiaoqian Liu
    The Fourth Affiliated Hospital, Harbin Medical University, Heilongjiang Province, PR China
    Int J Biol Markers 24:77-82. 2009
    A single nucleotide polymorphism (SNP) of the epidermal growth factor (EGF) gene +61 A/G in the 5'-untranslated region has been reported to be associated with susceptibility to glioma...
  41. doi Association between EGF promoter polymorphisms and cancer risk: a meta-analysis
    Wei Xu
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People s Republic of China
    Med Oncol 27:1389-97. 2010
    b>EGF promoter polymorphisms are observed to modulate EGF levels and thought to have effect on susceptibility to various carcinomas but the results are inconsistent...
  42. ncbi Association study of an epidermal growth factor gene functional polymorphism with the risk and prognosis of gliomas in Brazil
    Giovanni R Pinto
    Department of Biomedicine, Federal University of Piaui, Parnaiba, Brazil
    Int J Biol Markers 24:277-81. 2009
    Epidermal growth factor (EGF) plays an important role in cancer...
  43. pmc Association between EGF +61 G/A and glioma risk in a Chinese population
    Shujie Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    BMC Cancer 10:221. 2010
    Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues...
  44. ncbi Association between +61G polymorphism of the EGF gene and glioma risk in different ethnicities: a meta-analysis
    Dianhui Tan
    Department of Neurosurgery, First Affiliated Hospital of Shantou University Medical College, Shantou, PR China
    Tohoku J Exp Med 222:229-35. 2010
    Epidermal growth factor (EGF) plays a key role in survival of neural and glial precursor cells...
  45. ncbi Association between epidermal growth factor +61 G/A polymorphism and glioma risk in a Chinese Han population
    G Bao
    Department of Neurosurgery, the First Affiliated Hospital of the Medical College of Xi an Jiaotong University, Xi an, China
    J Int Med Res 38:1645-52. 2010
    The association between the +61 G/A polymorphism of the epidermal growth factor (EGF) gene and glioma risk remains controversial and unclear...
  46. doi Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls
    Teng Fei Li
    Department of Gastroenterology, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin, China
    DNA Cell Biol 31:568-74. 2012
    The epidermal growth factor (EGF) pathway stimulates proliferation and differentiation of epidermal and epithelial tissues, and plays an important role in tumorigenesis...
  47. doi A functional polymorphism in the epidermal growth factor gene is associated with risk for glioma in a Chinese population
    Yang Li
    Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, Dalian, People s Republic of China
    Genet Test Mol Biomarkers 16:449-52. 2012
    Epidermal growth factor (EGF) plays a key role in survival of neural and glial precursor cells...
  48. pmc Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis
    Jian Hong Zhong
    Hepatobiliary Surgery Department, Guangxi Medical University, Tumor Hospital, Nanning, People s Republic of China
    PLoS ONE 7:e32159. 2012
    ..is a complex process that may be influenced by many factors, including polymorphism in the epidermal growth factor (EGF) gene...
  49. pmc EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
    Jung Chien Cheng
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e34071. 2012
    In high-grade ovarian cancer cultures, it has been shown that epidermal growth factor (EGF) induces cell invasion by activating an epithelial-mesenchymal transition (EMT)...
  50. doi Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy
    Francisco das Chagas Abreu da Silveira
    Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niteroi, RJ, Brazil
    J Cancer Res Clin Oncol 138:1347-54. 2012
    Malignant gliomas are associated with alteration in EGF/EGFR signaling. Functional EGF+61A>G polymorphism is implicated with risk, recurrence, and progression of glioma...
  51. ncbi Genetic polymorphisms of EGF 5'-UTR and NAT2 857G/A associated with glioma in a case control study of Malaysian patients
    K A Muthusamy
    Department of Surgery, Division of Neurosurgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia
    Genet Mol Res 11:2939-45. 2012
    ..Epidermal growth factor (EGF) and the NAT2 gene play a central role in carcinogenesis...
  52. pmc A functional +61G/A polymorphism in epidermal growth factor is associated with glioma risk among Asians
    Xin Xu
    Department of Oncology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Wuxi, People s Republic of China
    PLoS ONE 7:e41470. 2012
    Epidermal growth factor (EGF), a potent mitogenic protein, plays an important role in the development of cancers, including glioma...
  53. doi EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis
    Y Feng
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University of Medicine, Shanghai, China
    Cell Prolif 45:413-9. 2012
    ..Growth factors such as epidermal growth factor (EGF) and basic fibroblast growth factor (b-FGF) promote cancer stem cell proliferation in many solid tumours...
  54. doi Ovarian cancer and genetic susceptibility: association of A61G polymorphism in the EGF gene
    Ana Paula Araújo
    Molecular Oncology Group, Portuguese Institute of Oncology, Porto Centre, Edifício Laboratórios PISO 4, Rua Dr Ant Bernardino Almeida, 4200 072 Porto, Portugal
    Exp Biol Med (Maywood) 234:241-5. 2009
    ..The epidermal growth factor (EGF) gene codifies a growth factor that binds to the EGF receptor (EGFR), which is involved in activating pathways that ..
  55. doi Association between epidermal growth factor 61A/G polymorphism and hepatocellular carcinoma susceptibility in Chinese patients
    Yajuan Li
    Department of Microbiology, Peking University Health Science Center, Beijing, China
    Liver Int 30:112-8. 2010
    ..The epidermal growth factor (EGF) pathway plays an important role in tumorigenesis, including HCC...
  56. ncbi A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer
    Yoichi Hamai
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 72:133-8. 2005
    Epidermal growth factor (EGF) has many biological functions and plays an important role in the progression of various tumors including gastric cancer...
  57. ncbi Epidermal growth factor 61 A/G polymorphism and uterine cervical cancer
    S Kang
    Uterine Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Int J Gynecol Cancer 17:492-6. 2007
    ..we hypothesized that a functional polymorphism in the 5' untranslated region of the epidermal growth factor (EGF) gene, a natural ligand of the EGFR, may play a role in the cervical carcinogenesis and tumor invasiveness...
  58. doi Epidermal growth factor genetic variation, breast cancer risk, and waiting time to onset of disease
    Ana Paula Araújo
    Molecular Oncology Group, Portuguese Institute of Oncology Porto, Porto 4200 072, Portugal
    DNA Cell Biol 28:265-9. 2009
    ..One of the most important is the epidermal growth factor (EGF), which is encoded by EGF gene...
  59. pmc Role of the EGF +61A>G polymorphism in melanoma pathogenesis: an experience on a large series of Italian cases and controls
    Milena Casula
    Unit of Cancer Genetics, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Sassari, Italy
    BMC Dermatol 9:7. 2009
    A single nucleotide polymorphism (61A>G) in the epidermal growth factor (EGF) gene has been implicated in both melanoma pathogenesis and increased melanoma risk...
  60. ncbi Human genes for insulin-like growth factors I and II and epidermal growth factor are located on 12q22----q24.1, 11p15, and 4q25----q27, respectively
    C C Morton
    Cytogenet Cell Genet 41:245-9. 1986
    ..The genes coding for insulin-like growth factors I and II and epidermal growth factor have been localized to human chromosomes 12q22----q24.1, 11p15, and 4q25----q27, respectively...
  61. ncbi Expression of insulin-like growth factor binding protein-3 (IGFBP-3) in human keratinocytes is regulated by EGF and TGFbeta1
    S R Edmondson
    Centre for Hormone Research, Royal Children s Hospital, Parkville, Victoria, Australia
    J Cell Physiol 179:201-7. 1999
    ..Here we examine the regulation of human keratinocyte-produced IGFBPs by epidermal growth factor (EGF), transforming growth factor beta 1 (TGFbeta1), and IGF-I, growth factors known to be active in skin...
  62. ncbi Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes
    M Kong
    Polypeptide Hormone Laboratory, Faculty of Medicine, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Biol Chem 275:36035-42. 2000
    ..protein kinase, pathway is necessary and sufficient to account for insulin- and epidermal growth factor (EGF)-induced DNA synthesis in rat hepatocytes...
  63. ncbi Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display
    Catelijne Stortelers
    Department of Cell Biology, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Biochemistry 41:8732-41. 2002
    Epidermal growth factor (EGF) binds with high affinity to the EGF receptor, also known as ErbB-1, but upon replacement of the N-terminal linear region by neuregulin (NRG) 1 or transforming growth factor (TGF) alpha sequences it gains in ..
  64. ncbi EGF +61 gene polymorphism and susceptibility to and prognostic markers in cutaneous malignant melanoma
    Sarah L McCarron
    Histocompatibility and Immunogenetics Laboratory, Southampton University Hospitals, Southampton, UK
    Int J Cancer 107:673-5. 2003
    ..A striking association between EGF polymorphism and Breslow thickness of invasive CMM has been reported...
  65. ncbi EGF gene polymorphism and the risk of incident primary melanoma
    Kandace L Amend
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 64:2668-72. 2004
    Overexpression of the epidermal growth factor (EGF) pathway has been implicated in melanoma pathogenesis, and a recent case-control study identified a single nucleotide polymorphism (G to A) in the EGF gene where the G allele was ..
  66. ncbi The relationship between the epidermal growth factor (EGF) 5'UTR variant A61G and melanoma/nevus susceptibility
    J A Randerson-Moor
    Genetic Epidemiology Division, Cancer Research UK, Cancer Genetics Building, St James s University Hospital, Leeds, UK
    J Invest Dermatol 123:755-9. 2004
    The inheritance of a G allele in position 61 in the 5'UTR of the epidermal growth factor (EGF) gene has been reported to increase melanoma susceptibility, a finding we have investigated in this study...
  67. ncbi Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population
    Yun Jeong Lim
    Department of Center for Health Promotion, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 135 710, South Korea
    Neurosci Lett 374:157-60. 2005
    ..Epidermal growth factor (EGF), one of the potent growth promoting factors, has been studied for its roles in cancer development...
  68. pmc EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I
    Munenori Takaoka
    Gastroenterology Division, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Gastrointest Liver Physiol 290:G404-16. 2006
    IGF and EGF regulate various physiological and pathological processes. IGF binding protein (IGFBP)-3 regulates cell proliferation in IGF-dependent and -independent fashions...
  69. ncbi The EGF A61G polymorphism is associated with disease-free period and survival in malignant melanoma
    Ichiro Okamoto
    Department of Dermatology, Center of Excellence and the Ludwig Boltzmann Institute for Clinical and Experimental Oncology, Medical University of Vienna, Vienna, Austria
    J Invest Dermatol 126:2242-6. 2006
    An earlier study reported that a common polymorphism in the 5' untranslated region of the epidermal growth factor (EGF) gene is associated with increased risk for cutaneous malignant melanoma (MM) and Breslow thickness...
  70. ncbi The 61 A/G EGF polymorphism is functional but is neither a prognostic marker nor a risk factor for glioblastoma
    Elodie Vauleon
    INSERM, U711, Biologie des Interactions Neurones and Glie, 75651 Paris Cedex 13, France
    Cancer Genet Cytogenet 172:33-7. 2007
    The A/G61 polymorphism located in the 5'UTR of the EGF gene has been found to be both a risk factor and a prognostic factor in glioblastoma (GBM), but the functional consequences have not been investigated...
  71. ncbi Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population
    Guangfu Jin
    Department of Epidemiology and Biostatistics, Cancer Research Center of Nanjing Medical University, Nanjing, China
    Cancer Sci 98:864-8. 2007
    Epidermal growth factor (EGF), a ligand of the EGF receptor, plays a critical role in the development of gastric cancer...
  72. pmc Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma
    Y Lemos-González
    Departamento de Bioquimica, Genética e Inmunología, Universidad de Vigo, As Lagoas Marcosende s n, 36310, Vigo, Spain
    Br J Cancer 96:1569-78. 2007
    Serum levels of the soluble epidermal growth factor receptor (sEGFR) and its ligands epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha) and amphiregulin (AR) were measured in healthy donors and patients with non-..
  73. ncbi Prostaglandins enhance epidermal growth factor-induced DNA synthesis in hepatocytes by stimulation of E prostanoid 3 and F prostanoid receptors
    Kristin Meisdalen
    Department of Pharmacology, Faculty of Medicine, University of Oslo, P O Box 1057 Blindern, N 0316 Oslo, Norway
    J Pharmacol Exp Ther 322:1044-50. 2007
    ..EP) and F prostanoid receptors (FP) in enhancing the growth-stimulatory effect of epidermal growth factor (EGF) in cultured hepatocytes. The EP2 receptor agonist butaprost had no significant effect on EGF-induced DNA synthesis...
  74. ncbi Epidermal growth factor (EGF) A61G polymorphism and EGF gene expression in normal colon tissue from patients with colorectal cancer
    Karen Lise G Spindler
    Department of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark
    Acta Oncol 46:1113-7. 2007
    b>EGF/EGFR interactions are important mechanisms behind colorectal tumour development and growth. Recently a single nucleotide polymorphism in the EGF gene has been identified (EGF A61G)...
  75. ncbi +61A>G polymorphism in the EGF gene does not increase the risk of lung cancer
    Hyo Gyoung Kang
    Cancer Research Institute, Kyungpook National University Hospital, Daegu, Korea
    Respirology 12:902-5. 2007
    Epidermal growth factor (EGF) plays an important role in tumourigenesis by binding with its receptor, EGFR...
  76. ncbi Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor
    M Uddin
    Allergy and Inflammation Research, Division of Infection, Inflammation and Repair, School of Medicine, Southampton, UK
    Eur Respir J 31:714-24. 2008
    ..study was to elucidate the mechanisms whereby the bronchial epithelium, stimulated by epidermal growth factor (EGF) as part of a response to acute or chronic injury, could activate and chemoattract human neutrophils...
  77. doi Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    JAMA 299:53-60. 2008
    Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels.
  78. pmc ESR1 and EGF genetic variation in relation to breast cancer risk and survival
    Kristjana Einarsdóttir
    Centre for Health Services Research, School of Population Health, University of Western Australia, 6009 Crawley, Perth, Western Australia
    Breast Cancer Res 10:R15. 2008
    ..of oestrogen effect in breast epithelia and has also been shown to be activated by epidermal growth factor (EGF)...
  79. doi Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer
    Monika Vishnoi
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Hum Immunol 69:360-7. 2008
    Epidermal growth factor (EGF) and transforming growth factor beta1 (TGFbeta1) play important roles in tumor biology...
  80. doi No association between epidermal growth factor and epidermal growth factor receptor polymorphisms and nasopharyngeal carcinoma
    Lin Bo Gao
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
    Cancer Genet Cytogenet 185:69-73. 2008
    ..Epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) interaction plays a pivotal role in cell proliferation, ..
  81. pmc Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth
    Jin Hong Kim
    Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:11149-53. 2009
    ..cells quantitatively reconcile the opposing effects of cell-cell contact and GFs, such as epidermal growth factor (EGF), remains unclear...
  82. ncbi No association of EGF 5'UTR variant A61G and hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection
    Peng Qi
    Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai PR China
    Pathology 41:555-60. 2009
    Epidermal growth factor (EGF) has many biological functions, including mitogenesis, tumorigenesis, and proliferation of epidermal tissues...
  83. doi The EGF 61A/G polymorphism - a predictive marker for recurrence of liver metastases from colorectal cancer
    Florian M Kovar
    Department of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria
    Wien Klin Wochenschr 121:638-43. 2009
    Epidermal growth factor (EGF) plays an important role in tumorigenesis. Variations in the DNA sequence of the gene EGF can lead to alterations in EGF activity, which is suspected to influence tumor progression...
  84. doi Genetic polymorphism of epidermal growth factor 61A>G and cancer risk: a meta-analysis
    Yan mei Zhang
    Department of Internal Medicine, the Second Hospital of Anhui Medical University, 678 Furong Road, Hefei 230601, China
    Cancer Epidemiol 34:150-6. 2010
    Numerous studies have investigated the risk of cancer associated with the polymorphism of epidermal growth factor (EGF) 61A>G, but the results have been inconsistent...
  85. doi Epidermal growth factor +61 G/A polymorphism and the risk of hepatocellular carcinoma in a Chinese population
    Kefei Chen
    Department of Surgery, Division of Liver, West China Hospital, Sichuan University, Chengdu, China
    Genet Test Mol Biomarkers 15:251-5. 2011
    ..Epidermal growth factor (EGF) plays an important role in tumorigenesis...
  86. pmc Involvement of 14-3-3 proteins in the second epidermal growth factor-induced wave of Rac1 activation in the process of cell migration
    Hiroki Kobayashi
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama 223 8522, Japan
    J Biol Chem 286:39259-68. 2011
    ..Here, we report that EGF induces biphasic Rac1 activation in the process of cell migration, and UTKO1, a cell migration inhibitor, inhibits ..
  87. pmc Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner
    Ronit Mor-Cohen
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Biol Chem 287:8879-91. 2012
    The β3 subunit of αIIbβ3 and αvβ3 integrins contains four epidermal growth factor (EGF)-like domains. Each domain harbors four disulfide bonds of which one is unique for integrins...
  88. ncbi Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia
    Michael R James
    Queensland Institute of Medical Research, Brisbane, Australia
    J Invest Dermatol 123:760-2. 2004
    A common single nucleotide polymorphism (SNP) in the 5' untranslated region (5'UTR) of the epidermal growth factor (EGF) gene modulates the level of transcription of this gene and hence is associated with serum levels of EGF...
  89. ncbi No association between EGF gene polymorphism and gastric cancer
    Yasuyuki Goto
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Cancer Epidemiol Biomarkers Prev 14:2454-6. 2005
    The etiology of gastric cancer is not well-understood. Epidermal growth factor (EGF) transduces growth signals to mitogen-activated protein kinase via RAS and BRAF, and EGF/EGF receptor interaction is important for tumor growth and ..
  90. ncbi EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women
    Yan Wang
    Laboratory of Reproductive Medicine, Cancer Research Center of Nanjing Medical University, Nanjing, China
    Breast Cancer Res Treat 111:321-7. 2008
    Epidermal growth factor (EGF), a potent mitogenic peptide, plays an important role in the development of cancers, including breast cancer. Previous studies showed that plasma EGF levels may influence the risk of cancer...
  91. doi Association between epidermal growth factor polymorphism and esophageal squamous cell carcinoma susceptibility
    Lin Cui
    Central Laboratory, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, Henan, People s Republic of China
    Dig Dis Sci 55:40-5. 2010
    ..Epidermal growth factor (EGF) can activate several signaling pathways leading to proliferation, differentiation, and tumorigenesis of epithelial ..
  92. ncbi Interleukin 1beta-converting enzyme (caspase-1) is overexpressed in adenocarcinoma of the pancreas
    S Gansauge
    Department of General Surgery, University of Ulm, Germany
    Cancer Res 58:2703-6. 1998
    ..This is the first report concerning ICE expression in human carcinomas; however, the exact mechanism underlying these close correlations warrant further research...
  93. ncbi The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy
    D D Torres
    Renal, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Kidney Int 73:327-33. 2008
    ..The aim of this study was to determine if measurements of urinary epidermal growth factor (EGF) and monocyte chemotactic peptide-1 (MCP-1), at the time of renal biopsy, were a predictor of end-stage renal ..
  94. pmc Roles for transforming growth factor-alpha in gastric physiology and pathophysiology
    R J Coffey
    Department of Medicine and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
    Yale J Biol Med 65:693-704; discussion 621-3. 1992
    ..TGF alpha and EGFR, but not EGF, are expressed in normal gastric mucosa...
  95. ncbi Biochemical comparisons of the normal and oncogenic forms of insect cell-expressed neu tyrosine kinases
    P M Guy
    Department of Biochemistry, Molecular, and Cell Biology, Cornell University, Ithaca, New York 14853-6401
    J Biol Chem 267:13851-6. 1992
    The rat neu oncogene product is a member of the epidermal growth factor (EGF) receptor subgroup of the superfamily of growth factor receptor tyrosine kinases...
  96. ncbi Expression of epidermal growth factor and epidermal growth factor receptor genes in healing colonic anastomoses in rats
    P Brasken
    Department of Surgery, University of Turku, Finland
    Eur J Surg 157:607-11. 1991
    This study uses complementary DNA probes to find out if epidermal growth factor (EGF) and EGF receptor genes are activated in healing colonic anastomoses in rats...
  97. ncbi Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot
    M Leone
    Department of Obstetrics and Gynecology, University of Genoa, Italy
    Horm Metab Res 23:442-5. 1991
    ..001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these ..
  98. ncbi Abnormalities of the EGF receptor system in human thyroid neoplasia
    N R Lemoine
    Molecular Pathology Laboratory, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Int J Cancer 49:558-61. 1991
    The epidermal-growth-factor receptor (EGF-r) and its ligands are involved in the control of proliferation of both normal and neoplastic thyroid epithelium...
  99. ncbi Epidermal growth factor receptors in genetically induced hyperproliferative skin disorders
    L B Nanney
    Department of Plastic Surgery and Cell Biology, Vanderbilt University, Nashville, Tennessee
    Pediatr Dermatol 7:256-65. 1990
    The presence and morphologic distribution of epidermal growth factor receptor (EGF-R) were investigated in a variety of genetic disorders that affect human epidermis...
  100. pmc Regulation of vascular and gastric smooth muscle contractility by pervanadate
    A Laniyonu
    Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB, Canada
    Br J Pharmacol 113:403-10. 1994
    ..of PV to mimic the action of the tyrosine kinase receptor-associated agonist, epidermal growth factor-urogastrone (EGF-Uro), in the gastric preparation was also studied. 2...
  101. ncbi Involvement of high-affinity binding site for EGF receptor in formation of rounding in A-431 epidermoid carcinoma cells
    T Atsumi
    Department of Oral Physiology, Meikai University School of Dentistry, Saitama, Japan
    Horm Metab Res 26:141-4. 1994
    ..cells and their neo gene-transfectants, we studied the relation between "rounding" and the high-affinity sites for EGF; and we also examined the role of protein kinase C (PKC) and A (PKA) in the EGF-induced cell rounding...

Research Grants71

  1. SIGNALING MECHANISMS IN EPIDERMAL GROWTH FACTOR ACTION
    Tarun Patel; Fiscal Year: 2002
    Epidermal Growth Factor (EGF) regulates a variety of biological events ranging from cell growth and proliferation to intermediary metabolism, heart rate and contractility...
  2. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..ADAM-17);and that iii) activation of ADAM-17 can mediate shedding of heparin-binding epidermal growth factor (HB-EGF) which in turn culminates in EGFR transactivation...
  3. c-Src/EGF Receptors Interactions and Therapeutic Resistance in Breast Cancer
    Sarah J Parsons; Fiscal Year: 2010
    ..Cox II binds phospho-Tyr 845 (pY845) of the EGFR, a novel site that is phosphorylated by c-Src following EGF treatment...
  4. Alessio Fasano; Fiscal Year: 2015
    ..will expand our studies to establish the mechanisms through which zonulin because PAR2- mediated transactivation of EGF. We have demonstrated that this transactivation is followed by protein kinase C (PKC)a-mediated ZO-1 and myosin 1c ..
  5. Molecular Mechanisms of EGF Signaling &Iressa/Tarceva Inhibition in NSCLC
    Karen S Anderson; Fiscal Year: 2012
    ..The studies described in this application are designed help unravel these molecular details to allow us to differentiate cancer cells from normal cells and assess the usefulness of current and new cancer therapies. ..
  6. Hyaluronan in Epidermal Injury Responses
    Edward Maytin; Fiscal Year: 2009
    ..We show that the mechanism of increased HA requires the release of HB-EGF, activation of the epidermal growth factor receptor (EGFR) pathway, and activation of the Has enzymes which ..
  7. Biomolecular Analysis using Liquid Crystals
    Nicholas L Abbott; Fiscal Year: 2013
    ..forms of the EGFR will exhibit differential inhibitor specificity, and c) assess if agents that potently inhibit EGF-mediated events in vitro will also exhibit a capacity to antagonize EGFR expression and/or activity in cell culture...
  8. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..The overall hypothesis to be tested is that EGF ligands act in an autocrine manner with the EGFR to regulate PTHrP expression in lung SCC and induce the ..
  9. Michael H Nathanson; Fiscal Year: 2014
    ..2. Whether and how EGF increases Ca2+ in the nucleus will be determined...
  10. Synthetic cannabinoids as novel therapeutic strategies against non-small cell lun
    Ramesh K Ganju; Fiscal Year: 2012
    ..is that synthetic cannabinoids that bind to CB1/CB2 receptors could be used as novel strategies to inhibit EGF/EGFR-mediated and CXCL12/CXCR4-mediated growth and metastasis in NSCLC...
  11. ErbB Signaling in Fetal Type II Cell Growth
    Heber C Nielsen; Fiscal Year: 2012
    ..The ErbB receptor family is comprised of four members: the Epidermal Growth Factor Receptor (EGF-R), ErbB2, ErbB3, and ErbB4...
  12. Gadiparthi N Rao; Fiscal Year: 2016
    ..shedding of heparin-binding growth factors, in this case, heparin-binding epidermal growth factor (HB-EGF), appears to be accountable for thrombin transactivation of EGFR, there appears to be a gap in our understanding of ..
  13. GERTRUD M SCHUPBACH; Fiscal Year: 2016
    ..Our work identifies further genes that act in the same pathway as the receptor and these genes will provide new targets for specific cancer drugs as well as allowing us to address side effects of available cancer drugs. ..
  14. SPORE in Pancreatic Cancer
    James Abbruzzese; Fiscal Year: 2009
    ..This project will specifically examine the hypothesis that EGF-EGF receptor interactions control PLA2 and COX2 expression in pancreatic cancer cells and that COX-2 regulates an ..
  15. CAML in T cell Development and Function
    Richard J Bram; Fiscal Year: 2011
    ..Epidermal Growth Factor Receptor (EGFR), and identified a direct interaction between CAML and the kinase domain of EGF-activated EGFR. We recently published new data revealing a critical role for CAML in thymocyte development...
  16. SIGNALING BY NEUREGULINS AND ERBB4 IN BREAST CANCER
    David F Stern; Fiscal Year: 2013
    ..The first receptor (EGF receptor) is a therapeutic target in two of the greatest human cancer killers: non-small cell lung carcinoma and ..
  17. Mingzhi Zhang; Fiscal Year: 2016
    ..funding period have indicated that the membrane-associated form of EGFR ligands, and specifically heparin-binding EGF-like growth factor (HB-EGF), subserves different functions than the soluble mature form of the ligands and helps to ..
  18. Identification of novel genes regulating metalloproteinase activity
    Andreas Herrlich; Fiscal Year: 2009
    ..In my earlier work I discovered that certain metalloproteinase-cleaved EGF ligands are involved in G-protein signal transduction to MAPkinase and also in osmotic stress signaling to ..
  19. DOUGLAS TILLEY; Fiscal Year: 2016
    ..Further, differential ligand stimulation of the [unreadable]1AR-EGFR complex by catecholamine or EGF was shown to induce divergent receptor complex internalization and trafficking of downstream effectors...
  20. Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor Inhibition
    CRAIG WOODWORTH; Fiscal Year: 2009
    ..The epidermal growth factor receptor (EGF-R) is a relevant target...
  21. Receptor Tyrosine Kinase Signaling Networks
    Joannes B Hoek; Fiscal Year: 2010
    ..this application we will determine the molecular and kinetic factors controlling the different response patterns to EGF and insulin, validate hypotheses about the regulation of the spatio- temporal dynamics and EGFR-IR crosstalk ..
  22. The relationship between epidermal growth factor receptor and hedgehog signaling
    Robert B Rebhun; Fiscal Year: 2011
    ..Epidermal growth factor receptor (EGF-R) and Hedgehog (Hh) signaling pathways are independently known to contribute to the development or progression of ..
  23. Nuclear EGFR Signaling Network in Human Cancer
    Hui Wen Lo; Fiscal Year: 2010
    ..Accumulating evidences revealed a novel mode of EGFR signaling in which EGF ligand shuttles EGFR into the nucleus, leading to cyclin D1 gene activation...
  24. Robert B Rebhun; Fiscal Year: 2015
    ..Epidermal growth factor receptor (EGF-R) and Hedgehog (Hh) signaling pathways are independently known to contribute to the development or progression of ..
  25. Natural EGFR Antagonists and Cancer
    Renato V Iozzo; Fiscal Year: 2010
    ..nM) binding sites on the A431 cells, the vast majority (up to 75%) of which can be competitively displaced by EGF. These novel results suggest that the soluble ectodomain of LRIG1, which could conceivably be released at sites of ..
  26. Daniel C Morris; Fiscal Year: 2014
    ..In addition, our preliminary data suggests that the epidermal growth factor receptor (EGF-R) likely mediates the effect of TB4 on OPCs...
  27. BJOERN MARKUS REINHARD; Fiscal Year: 2016
    ..The operational form in the EGFR signal transduction pathway is not the individual EGF receptor, but dimers and potentially higher order oligomers or even larger functional units, referred to as ..
  28. GERARDO M CASTILLO; Fiscal Year: 2014
    ..At the end of Phase 2, we will have a single treatment regimen which we will use to collect data for an IND filing. ..
  29. A temporospatial analysis of epithelial integrity following vocal fold injury
    Ciara Leydon; Fiscal Year: 2013
    ..the distribution of epidermal growth factor receptors (EGFR) and two growth factors that regulate EGFR activation (EGF and TGF2) in epithelium at critical time points following injury...
  30. Synergism of c-Met and EGFR pathways: their therapeutic role in lung cancer
    Neelu Puri; Fiscal Year: 2013
    ..A. Determine if resistance developed to EGFR/c-Met RTKIs alters response to EGF or HGF and increases c- Met stability. B...
  31. Joseph Scafidi; Fiscal Year: 2015
    ..In aim 1, Dr Scafidi will determine the role of EGF on oligodendrocyte regeneration and developmental myelination after chronic perinatal hypoxia...
  32. SABRINA LEIGH SAMUDIO-RUIZ; Fiscal Year: 2016
    ..abstract_text> ..
  33. Epidermal growth factor regulation of miR-125a promotes invasive ovarian cancer
    KAREN COWDEN DAHL; Fiscal Year: 2009
    ..I determined that EGF treatment reduces mir125a expression and miR-125a regulates metastasis relevant targets in ovarian tumor cells...
  34. Epidermal growth factor regulation of miR-125a promotes invasive ovarian cancer
    KAREN DENISE COWDEN DAHL; Fiscal Year: 2012
    ..I determined that EGF treatment reduces mir125a expression and miR-125a regulates metastasis relevant targets in ovarian tumor cells...
  35. Alexander D Sorkin; Fiscal Year: 2016
    ....
  36. Force Sensing with Nanotubes
    Fred A Pereira; Fiscal Year: 2012
    ..Growth factors (e.g., epidermal growth factor, EGF) initiate actin remodeling by targeting their receptors (e.g...
  37. Konstantin V Sokolov; Fiscal Year: 2015
    ..For highly sensitive detection of cancer cells, we will explore EGF receptor mediated endocytosis and the effect of plasmon resonance coupling between closely spaced molecular ..
  38. Kathryn M Ferguson; Fiscal Year: 2015
    ..Currently-used EGFR-targeted antibody therapeutics were specifically selected to inhibit EGF binding and EGF-dependent activation of the receptor...
  39. Alexei A Bogdanov; Fiscal Year: 2016
    ..propose to harness the MRamp technique to meet the challenges of MR molecular imaging of epidermal growth factor (EGF) receptor and EpCAM cell-surface molecule as potential markers for targeted imaging of metastasis...
  40. Crosstalk among Growth Factors, ADAMs and Integrins
    Monika Gooz; Fiscal Year: 2010
    ..a) If yes, we will examine whether these processes involve the same EGF-like growth factor (namely heparin-bound EGF) or whether distinct EGF-like growth factors are employed by the ..
  41. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    BARRY MATTHEW MARKAVERICH; Fiscal Year: 2013
    ..CDC25A, PCNA, PLK1) expression in PC-3 human prostate cancer cells in addition to a number of genes involved in the EGF Signaling Pathway (EGFR, GRB2, SOS, RasGAP, MKK4, c-Fos, JNK1)...
  42. Radhakrishna Rao; Fiscal Year: 2014
    ..Furthermore, our studies demonstrated that epidermal growth factor (EGF) and L-glutamine prevent acetaldehyde-mediated increase in permeability to endotoxins by a PLC?, PKC?, PKC?I and ..
  43. Radhakrishna Rao; Fiscal Year: 2016
    ..Our studies also demonstrated that EGF, a GI mucosal protective factor, prevents the oxidative stress-induced disruption of tight junctions;this process ..
  44. Akt/mTOR Signaling in Energy Balance Modulation of Epithelial Carcinogenesis
    Stephen D Hursting; Fiscal Year: 2013
    ..of Akt and mTOR, including reduced phosphorylation of the IGF-1 receptor (IGF-1R) and epidermal growth factor (EGF)-R, in several tissues including the epidermis;and ii) liver-specific IGF-1 deficiency (LID, resulting in reduced ..
  45. Control of NF-kappaB Activity
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..apos;Furthermore, we find that IKKcz is required to control epidermal growth factor (EGF)-induced histone H3 serl0 phosphorylation and that GSK-313 controls the phosphorylation of the p65 subunit on ..
  46. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2009
    ..Our studies also demonstrated that EGF, a GI mucosal protective factor, prevents the oxidative stress-induced disruption of tight junctions;this process ..
  47. Bal L Lokeshwar; Fiscal Year: 2015
    ..one is androgen-androgen receptor regulated growth and the other peptide hormones, such as Epidermal Growth Factor (EGF) and Insulin-like growth factor-1, stimulated prostate tumor growth and survival...
  48. Modulation of MUC1 Mucin Trafficking
    Rebecca P Hughey; Fiscal Year: 2010
    ..glycosylated ectodomain, functions as a cell surface receptor/sensor and a modifier of epidermal growth factor (EGF) signaling...
  49. Structural Studies of Growth Factor Receptor Function
    Daniel J Leahy; Fiscal Year: 2010
    ..Twenty different classes of RTKs are found in humans and include receptors for insulin, epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF)...
  50. Daniel H Teitelbaum; Fiscal Year: 2014
    ..preliminary data also shows that the addition of glutamine to TPN, exogenous epidermal growth factor (EGF) or the removal of pro-inflammatory cytokines can prevent many of these TPN-associated changes...
  51. Russell E McConnell; Fiscal Year: 2014
    ..shown that metastatic cancer cells that migrated out of a primary tumor in response to Epidermal Growth Factor (EGF) had increased expression levels of Mena, one of three members of the Ena/VASP family...
  52. VICKERY E TRINKAUS-RANDALL; Fiscal Year: 2016
    ..response, which led to our laboratory showing an interaction between the purinergic and Epidermal Growth Factor(EGF) receptor(R) signaling pathways...
  53. Martín Ernesto Fernandez-Zapico; Fiscal Year: 2016
    ..factor GLI1 as a shared effector for both pancreatic oncogenic pathways, Hedgehog (HH) and Epidermal Growth Factor (EGF), engendering a pro-survival/anti-apoptotic function in pancreatic cancer cells...
  54. Dual Targeting of MEK and EGFR Signaling Pathways in Advanced Pancreatic Cancer
    Andrew H Ko; Fiscal Year: 2012
    ..When breast and pancreatic cancer cell lines are treated with a MEK inhibitor, phosphorylation of the EGF receptor is markedly enhanced with resultant activation of the PI3K pathway as measured by phosphorylated AKT...
  55. Small-molecule inhibitors of hADAM12
    Jens Berthelsen; Fiscal Year: 2012
    ..abnormal cell division and proliferation due to enhanced release of growth factors such as epidermal growth factor (EGF) or tumor necrosis factor [unreadable] (TNF-[unreadable])...
  56. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..of the present proposal is to determine: (1) if sensory nerves in the cornea stimulate epidermal growth factor (EGF) release from the conjunctiva, perhaps from the goblet cells, to stimulate goblet cell proliferation and (2) the ..
  57. ErbB signaling in vertebrate morphogenesis
    Chenbei Chang; Fiscal Year: 2010
    ..signaling involves four related receptor tyrosine kinases (ErbBs) that mediate actions of epidermal growth factor (EGF) and its related growth factors...
  58. ADAM 17 and glioma-tumor progression and treatment
    Feng Jiang; Fiscal Year: 2013
    ..Hypothesis 1b: ADAM17 activation of the epidermal growth factor (EGF) signaling pathway promotes glioma invasion, cell proliferation and survival, by stimulating the PI3K/Akt pathway...
  59. Zhimin Lu; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Overexpression of epidermal growth factor (EGF) receptor (EGFR) and transactivation of ?-catenin have been detected separately in many human tumors and correlate with a poor clinical prognosis...
  60. EGF-R MODULATION AND RESPONSES IN COLON CARCINOMA
    Lynn Yeoman; Fiscal Year: 1992
    b>EGF-R Modulation and Responses in Colon Carcinoma - The research proposed in this application will examine the role of epidermal growth factor receptor (EGF-R) and transforming growth factor-alpha (TGF-a) levels of expression upon the ..
  61. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..gold nanoparticles conjugated to Pc 4 and tethered peptide ligands for targeting epidermal growth factor (EGF) and transferrin (Tf) cell surface receptors, which are overexpressed in brain cancer cells...
  62. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..by reactive astrocytes and are regulated by transforming growth factor-2 (TGF-2) and epidermal growth factor (EGF). CSPGs have key regulatory functions during migration, proliferation and differentiation of pre-OL...
  63. Lisa M Coussens; Fiscal Year: 2015
    ..TAMs) promote tumor growth and enhance pulmonary metastasis by high-level expression of epidermal growth factor (EGF) and activation of EGF-regulated signaling in mammary epithelial cells (MECs) critical for invasive tumor growth ..
  64. Robert S Hoover; Fiscal Year: 2015
    ..MAPK will be examined as a central mediator of the hormonal/physiological effects of Epidermal Growth Factor (EGF) and the Calcium-sensing Receptor (CaSR) on NCC...
  65. EGF/Gastrin for islet cell regeneration
    GERARDO M CASTILLO; Fiscal Year: 2010
    ..A recent reports demonstrate that a combination therapy of Epidermal Growth Factor (EGF) and gastrin increases beta cell mass and reverses hyperglycemia in diabetic mice and rats...
  66. EPIDERMAL GROWTH FACTOR & MEMBRANE PHOSPHORYLATION
    Lloyd King; Fiscal Year: 1992
    ..we demonstrated that protein phosphorylation was one of the initial signals induced by Epidermal Growth Factor (EGF) binding to its specific receptor-tyrosine kinase (EGF-R) on sensitive cells...
  67. EPIDERMAL GROWTH FACTOR AND SPERMATOGENESIS
    Carlos Suarez Quian; Fiscal Year: 1999
    There is now compelling evidence to suggest that epidermal growth factor (EGF) is involved in the control of spermatogenesis...
  68. The Role of Epidermal Growth Factor in Sepsis
    Jessica Clark; Fiscal Year: 2009
    ..Epidermal growth factor (EGF) is a peptide that has been shown to protect the intestinal epithelium in several injury models...
  69. EGF SIGNALING PATHWAYS & GENE EXPRESSION IN THE GH4 CELL
    Cheryl Pickett; Fiscal Year: 2001
    Epidermal growth factor (EGF) and its receptor (EGF-R) have a fundamental role in controlling cell growth, differentiation and neoplasia...
  70. GROWTH FACTORS IN BRAIN PLASTICITY AND DEVELOPMENT
    Harley Kornblum; Fiscal Year: 2000
    ..TGFalpha and EGF, which at the EGF receptor (EGF-R) have been shown to exert trophic activities on striatal, cortical, and ..
  71. RECEPTORS AND PHOSPHOINOSITIDE METABOLISM IN THE CORNEA
    RASHID AKHTAR; Fiscal Year: 2000
    DESCRIPTION: The biochemical mechanism by which epidermal growth factor (EGF) promotes corneal epithelial wound healing is unclear...