EFNA5

Summary

Gene Symbol: EFNA5
Description: ephrin A5
Alias: AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS, ephrin-A5, AL-1, LERK-7, eph-related receptor tyrosine kinase ligand 7
Species: human

Top Publications

  1. ncbi Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation
    J W Winslow
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Neuron 14:973-81. 1995
  2. ncbi Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
  3. ncbi Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
    Juha Pekka Himanen
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Neurosci 7:501-9. 2004
  4. doi Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
    Sabine H Wimmer-Kleikamp
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 112:721-32. 2008
  5. doi EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor
    J J Li
    Laboratory of Molecular Oncology, Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Shanghai, People s Republic of China
    Oncogene 28:1759-68. 2009
  6. doi Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma
    Thomas Kalinski
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Hum Pathol 40:1679-85. 2009
  7. ncbi The ancestry and cumulative evolution of immune reactions
    Jolanta M Dzik
    Nencki Institute of Experimental Biology, Department of Biochemistry, Warsaw University of Life Sciences, Warszawa, Poland
    Acta Biochim Pol 57:443-66. 2010
  8. ncbi Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system
    J Frisen
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Neuron 20:235-43. 1998
  9. ncbi Structure-activity relationships of 18 endogenous neuropeptides on the motor nervous system of the nematode Ascaris suum
    R E Davis
    Department of Zoology, University of Wisconsin Madison, 53706, USA
    Peptides 22:7-23. 2001
  10. ncbi EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Quebec, Department of Medicine, Laval University, Canada
    J Steroid Biochem Mol Biol 69:51-84. 1999

Research Grants

  1. Structural and functional studies of the nuclear receptor PPARgamma
    H Eric Xu; Fiscal Year: 2010
  2. BIOCHEMISTRY AND REGULATION OF V(D)J RECOMBINATION
    Mark S Schlissel; Fiscal Year: 2012
  3. GWEN BUEL; Fiscal Year: 2015
  4. Spatiotemporal Comparison of Aberrant & Ectopic VDJ Recombination Events In Vivo
    PENNY ELLEN SHOCKETT; Fiscal Year: 2010
  5. John Blenis; Fiscal Year: 2016
  6. Ruikang Wang; Fiscal Year: 2015
  7. Zhi Yang Tsun; Fiscal Year: 2014
  8. INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEM
    DAN CORNELL; Fiscal Year: 1993
  9. New models for RAG-mediated lymphomagenesis
    SANDRA SALUS; Fiscal Year: 2004
  10. EPH MOLECULES IN HIPPOCAMPAL TOPOGRAPHIC PROJECTIONS
    Renping Zhou; Fiscal Year: 1999

Detail Information

Publications247 found, 100 shown here

  1. ncbi Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation
    J W Winslow
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Neuron 14:973-81. 1995
    ..Our findings, together with the observation that both molecules are expressed in the brain, suggest a role in the formation of neuronal pathways, a crucial feature of nervous system development and regeneration...
  2. ncbi Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
    ....
  3. ncbi Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
    Juha Pekka Himanen
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Neurosci 7:501-9. 2004
    ..The structural data reveal the molecular basis for EphB2-ephrin-A5 signaling and provide a framework for understanding the complexities of functional interactions and crosstalk between A- and B-subclass Eph receptors and ephrins...
  4. doi Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
    Sabine H Wimmer-Kleikamp
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 112:721-32. 2008
    ....
  5. doi EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor
    J J Li
    Laboratory of Molecular Oncology, Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Shanghai, People s Republic of China
    Oncogene 28:1759-68. 2009
    ..These findings may improve therapeutic strategies for glioma...
  6. doi Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma
    Thomas Kalinski
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Hum Pathol 40:1679-85. 2009
    As ephrins have been associated with tumorigenesis and tumor progression, we investigated ephrin-A5 (EFNA5) expression in specimens of normal cartilage and chondrosarcomas of different grade by conventional and quantitative reverse ..
  7. ncbi The ancestry and cumulative evolution of immune reactions
    Jolanta M Dzik
    Nencki Institute of Experimental Biology, Department of Biochemistry, Warsaw University of Life Sciences, Warszawa, Poland
    Acta Biochim Pol 57:443-66. 2010
    ..histocompatibility complex (MHC), T-cell receptor (TCR), B-cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes...
  8. ncbi Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system
    J Frisen
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Neuron 20:235-43. 1998
    Ephrin-A5 (AL-1/RAGS), a ligand for Eph receptor tyrosine kinases, repels retinal axons in vitro and has a graded expression in the superior colliculus (SC), the major midbrain target of retinal ganglion cells...
  9. ncbi Structure-activity relationships of 18 endogenous neuropeptides on the motor nervous system of the nematode Ascaris suum
    R E Davis
    Department of Zoology, University of Wisconsin Madison, 53706, USA
    Peptides 22:7-23. 2001
    ..One category of AF peptides, N-terminally extended -FIRFa peptides (AF5, AF7 and AF1), has pronounced behavioral effects and qualitatively similar, but quantitatively different effects on DE2 and DI ..
  10. ncbi EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Quebec, Department of Medicine, Laval University, Canada
    J Steroid Biochem Mol Biol 69:51-84. 1999
    ..An important aspect of EM-652 is that it inhibits both the AF1 and AF2 functions of both ER alpha and ER beta while the inhibitory action of hydroxytamoxifen is limited to AF2, ..
  11. ncbi Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells
    A Sakamoto
    Division of Vascular Biology, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan
    J Int Med Res 39:522-7. 2011
    ..The following 17 members were detected in adult human peripheral blood monocytes: EFNA1 and EFNA3 - EFNA5 (coding for ephrins A1 and A3 - A5); EPHA1, EPHA2, EPHA4 - EPHA6 and EPHA8 (coding for Eph receptors A1, A2, A4 - ..
  12. pmc African 1, an epidemiologically important clonal complex of Mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad
    Borna Muller
    Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland
    J Bacteriol 191:1951-60. 2009
    ..We have named this group of strains the African 1 (Af1) clonal complex and have defined the spoligotype signature of this clonal complex as being the same as the M...
  13. pmc Cytosines, but not purines, determine recombination activating gene (RAG)-induced breaks on heteroduplex DNA structures: implications for genomic instability
    Abani Kanta Naik
    Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
    J Biol Chem 285:7587-97. 2010
    ..b>RAGs can also act as structure-specific nuclease; however, little is known about the mechanism of its action...
  14. ncbi Changes in locomotory behavior and cAMP produced in Ascaris suum by neuropeptides from Ascaris suum or Caenorhabditis elegans
    C A Reinitz
    Department of Zoology, University of Wisconsin Madison, 1117 West Johnson Street, Madison, WI 53706, USA
    Mol Biochem Parasitol 111:185-97. 2000
    ..Injection of AF1 (KNEFIRFamide) or AF2 (KHEYLRFamide) inhibited the propagation of locomotory waves and reduced the number of ..
  15. ncbi Effects of KHEYLRFamide and KNEFIRFamide on cyclic adenosine monophosphate levels in Ascaris suum somatic muscle
    D P Thompson
    Pharmacia Animal Health, 7923 25 410, 7000 Portage Road, Kalamazoo, MI 49001 0199, USA
    Int J Parasitol 33:199-208. 2003
    ..Another excitatory FaRP present in nematodes, KNEFIRF-NH(2) (AF1), also stimulated cAMP production, but was 100-fold less potent than AF2...
  16. pmc Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators
    Viola Tamasi
    Department of Biochemistry and Molecular Biology, U Louisville School of Medicine, Louisville, KY 40292, USA
    Mol Pharmacol 73:968-76. 2008
    ..DHEA action involves induction of PPARalpha mRNA and protein levels as well as increased PPARalpha transcriptional activity through decreasing receptor phosphorylation at serines in the AF1 region.
  17. doi Pathological, biochemical and haematological investigations on the protective effect of alpha-lipoic acid in experimental aflatoxin toxicosis in chicks
    M Karaman
    Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey
    Br Poult Sci 51:132-41. 2010
    ..10 Ross PM3 chicks were given, for 21 d, no AF (C), 60 mg/kg/bwt of alpha-lipoic acid (LA), 150 ppb of aflatoxin (AF1), 150 ppb of aflatoxin plus 60 mg/kg/bwt of alpha-lipoic acid (AF1 + LA), 300 ppb of aflatoxin (AF2), and 300 ppb ..
  18. ncbi Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate
    S M Powell
    Prostate Cancer Research Group, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Endocr Relat Cancer 11:117-30. 2004
    ..transcription factors usually contain two activation functions, a ligand-independent activation function 1(AF1) in the divergent N-terminal domain and a ligand-dependent AF2 in the more conserved C-terminal ligand-binding ..
  19. pmc Immunoblot assay using recombinant antigens as a supplemental test to confirm the presence of antibodies to Trypanosoma cruzi
    Kevin Y Cheng
    Emerging Pathogens and Infectious Diseases R and D, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064, USA
    Clin Vaccine Immunol 14:355-61. 2007
    ..cruzi in which four chimeric recombinant antigens (rAgs), designated FP3, FP6, FP10, and TcF, are used as target antigens...
  20. pmc Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia
    Shao Qing Kuang
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 115:2412-9. 2010
    ..Expression analysis of EPHB4, EFNB2, and EFNA5 genes demonstrated that DNA methylation was associated with gene silencing...
  21. ncbi Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis
    A M Flenniken
    Division of Developmental Neurobiology, National Institute for Medical Research, London, United Kingdom
    Dev Biol 179:382-401. 1996
    ..We find that B61, AL-1/RAGS, LERK4, and ELF-1, members of the GPI-anchored subgroup of ligands, have both distinct and overlapping aspects to ..
  22. ncbi Typical atrial flutter ablation: conduction across the posterior region of the inferior vena cava orifice may mimic unidirectional isthmus block
    M Scaglione
    Division of Cardiology, Civil Hospital, Asti, Italy
    J Cardiovasc Electrophysiol 11:387-95. 2000
    ....
  23. ncbi Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression
    C Logan
    Department of Developmental Neurobiology, UMDS, Guy s Hospital, London SE1 9RT, UK
    Curr Biol 6:1006-14. 1996
    ..The En gradient also correlates with the expression of two putative retinal axon-guidance molecules, RAGS and ELF-1, which are Eph-like receptor tyrosine kinase ligands that may function in the establishment of ..
  24. pmc Effects of different osmolytes on the induced folding of the N-terminal activation domain (AF1) of the glucocorticoid receptor
    R Kumar
    Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1071, USA
    Arch Biochem Biophys 465:452-60. 2007
    ..In order to understand gene regulation by glucocorticoids, it is pivotal to know how the major transactivation domain AF1 of the glucocorticoid receptor (GR) functions...
  25. ncbi [Feasibility of home self-administration of low molecular weight heparin by patients with atrial fibrillation recurrence. A new approach to thromboembolic prophyllaxis]
    Dariusz A Kosior
    Katedra i Klinika Kardiologii i Wydziału Lekarskiego AM w Warszawie
    Pol Arch Med Wewn 114:1204-11. 2005
    ..We checked the feasibility of self-screening for atrial fibrillation (AF) by instructed patients pts and prompt home self-administration of an initial dose of low-molecular weight heparin (LMWH) prior to seeking medical attention...
  26. doi Vaccination with recombinant Mycobacterium avium subsp. paratuberculosis proteins induces differential immune responses and protects calves against infection by oral challenge
    Kumanan Kathaperumal
    Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vaccine 26:1652-63. 2008
    We previously reported the in vitro cellular immune responses to recombinant antigens (rAgs) of Mycobacterium avium subsp. paratuberculosis (MAP)...
  27. ncbi Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands
    R Zhou
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Cell Tissue Res 290:251-9. 1997
    ..In contrast, at least three different ligands, viz., Elf-1, LERK3/Ehk1-L, and AL-1/RAGS/LERK7, are transcribed in complementary (opposing) gradients in the hippocampal subcortical target, the lateral septum...
  28. ncbi Risk of polycyclic aromatic hydrocarbon (PAH) exposure from ingested food: the Azerbaijan case study
    Oke C Nwaneshiudu
    Department of Water Management and Hydrologic Science, Texas A and M University, College Station, Texas, USA
    J Environ Sci Health B 42:201-9. 2007
    ..S. EPA) Risk Assessment Guidance for Superfund (RAGS) Part A was used in performing the risk assessments...
  29. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  30. pmc Differential regulation of the transcriptional activity of the glucocorticoid receptor through site-specific phosphorylation
    Raj Kumar
    Division of Gastroenterology
    Biologics 2:845-54. 2008
    ..sites in the human GR are located in the N-terminal domain including the major transactivation domain, AF1. Available literature clearly indicates that many of these potential phosphorylation sites are substrates for ..
  31. pmc Human papillomavirus type 16 sequence variants: identification by E6 and L1 lineage-specific hybridization
    C M Wheeler
    Department of Cell Biology, New Mexico Cancer Research and Treatment Center, University of New Mexico School of Medicine, Albuquerque 87131, USA
    J Clin Microbiol 35:11-9. 1997
    ..variant lineages detected included European prototype-like (E-P), Asian (As), Asian-American (AA), and African (Af1 and Af2) lineages. In addition, E-G131, an E-class variant, and AA-G183, an AA-class variant, were also identified...
  32. pmc TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain
    Raj Kumar
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 101:16425-30. 2004
    ..Expressed independently as a recombinant peptide, the N-terminal transactivation domain (AF1) of the GR shows little structure and appears to exist as a collection of random coil configurations...
  33. doi Children of the sug: a study of the daily lives of street children in Khartoum, Sudan, with intervention recommendations
    Mustafa Kudrati
    International Research Consultant to the Save the Children Alliance, Khartoum, Sudan
    Child Abuse Negl 32:439-48. 2008
    ..The study examines street children's daily lives in Khartoum, Sudan to recommend ways to improve their conditions and to successfully assist them off the streets...
  34. ncbi Expression of recombination-activating genes and T cell receptor gene recombination in the human T cell leukemia cell line
    Hong yun Zou
    Institute of Molecular Immunology, School of Biotechnology, Southern Medical University, Guangzhou 510515, China
    Chin Med J (Engl) 120:410-5. 2007
    ..Here we used the Jurkathuman T cell line, which represents a mature stage of T cell development, as a model to investigate the regulation of Tcell receptor (TCR) gene recombination...
  35. ncbi Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids
    Efstathia Thymiakou
    Laboratory of Biochemistry, Department of Basic Sciences, University of Crete Medical School, and Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology of Hellas, Heraklion, Crete 71110, Greece
    Biochemistry 46:11473-83. 2007
    ..that physical interactions between Sp1 and LXRalpha require the N-terminal region of LXRalpha, which includes the AF1 and DNA binding domains and two different domains of Sp1: the transactivation domain B and the DNA binding domain...
  36. ncbi Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity
    Michael D Rudd
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mol Endocrinol 38:673-90. 2007
    ..Furthermore, both FOXOA3 and FOXOA3-mDBD enhanced the activity of a transcriptionally defective PGRA lacking its AF1 transactivation domain, indicating that this region of the receptor is not essential in this context...
  37. ncbi In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
    U Drescher
    Max Planck Institute for Developmental Biology, Department of Physical Biology, Tubingen, Federal Republic of Germany
    Cell 82:359-70. 1995
    ..We named the protein RAGS (for repulsive axon guidance signal)...
  38. ncbi Characterization of the recombinase activating gene-1 and 2 locus in the Japanese pufferfish, Fugu rubripes
    B R Peixoto
    The Molecular Sciences Institute, Berkeley, CA, USA
    Gene 246:275-83. 2000
    ..The human ACS was identified in a cosmid assigned to chromosome 11p11, which is close to the location of the RAGs (11p12). This indicates conservation of linkage between human and pufferfish.
  39. ncbi Differential control of gene activity by isoforms A, B1 and B2 of the Drosophila ecdysone receptor
    J F Mouillet
    Institute for Cell Biology, ETH Honggerberg, Zurich, Switzerland
    Eur J Biochem 268:1811-9. 2001
    ..Furthermore, they provide evidence for the existence of an autonomous ligand-independent activation function (AF1) in the A/B domains of EcRB1 and EcRB2 and of an inhibitory function (IF) in the A/B domain of EcRA.
  40. ncbi Distribution of 19 major virulence genes in Legionella pneumophila serogroup 1 isolates from patients and water in Queensland, Australia
    Bixing Huang
    Public Health Microbiology Laboratory, Queensland Health Scientific Services, Coopers Plains, QLD 4108, Australia
    J Med Microbiol 55:993-7. 2006
    ..lvh and rtxA with the virulent and predominant genotype detected by amplified fragment length polymorphism, termed AF1, whereas the avirulent common isolate from water termed AF16 did not have lvh or rtxA genes, with the exception of ..
  41. ncbi Aberrant DNA methylation imprints in aborted bovine clones
    Jing he Liu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Beijing, China
    Mol Reprod Dev 75:598-607. 2008
    ..in four aborted clones we tested, but Xist and Peg10 exhibited relatively better maintained methylation status in AF1 and AF4...
  42. ncbi Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping
    Britta Spanier
    ABI Molecular Neurogenetics, Ludwig Maximilians University, Munich, Germany
    J Mol Biol 352:429-37. 2005
    ..the pharyngeal activity showed a high sensitivity of the nep-1 pharynx to serotonin (5-HT) and to the neuropeptide AF1 (C...
  43. ncbi The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors
    S A Onate
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 273:12101-8. 1998
    ..We also demonstrate that SRC-1 interacts with both the amino-terminal A/B or AF1-containing domain and the carboxyl-terminal D/E or AF2-containing domain of the steroid receptors...
  44. ncbi Characterization of chromatin structure and enhancer elements for murine recombination activating gene-2
    Xing Cheng Wei
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Immunol 169:873-81. 2002
    Recombination-activating genes (RAGs) play a critical role in V(D)J recombination machinery and their expression is specifically regulated during lymphocyte ontogeny...
  45. doi Effectiveness of melatonin on aflatoxicosis in chicks
    Hasan Ozen
    Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey
    Res Vet Sci 86:485-9. 2009
    ..One of the groups was kept as a control (C), and the others were given 150ppb aflatoxin (AF1), 300ppb aflatoxin (AF2), 150ppb aflatoxin plus 10mg/kg/bwt melatonin (AF1+M), 300ppb aflatoxin plus 10mg/kg/bwt ..
  46. doi Purification of a new antifungal compound produced by Lactobacillus plantarum AF1 isolated from kimchi
    E J Yang
    Department of Food and Nutrition, Chosun University, Gwangju 501 759, Republic of Korea
    Int J Food Microbiol 139:56-63. 2010
    The aim of this study was to purify and to identify an antifungal compound of Lactobacillus plantarum AF1, which was isolated from kimchi, and to determine if Lb. plantarum AF1 can prevent fungal growth in a particular food model system...
  47. ncbi Function of steroidogenic factor 1 domains in nuclear localization, transactivation, and interaction with transcription factor TFIIB and c-Jun
    L A Li
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Mol Endocrinol 13:1588-98. 1999
    ..SF-1 does not have an N-terminal AF1 domain...
  48. ncbi Identification and characterization of four strains of Acidithiobacillus ferrooxidans isolated from different sites in China
    Hong Chen
    Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, PR China
    Microbiol Res 164:613-23. 2009
    Four strains of Acidithiobacillus ferrooxidans (A. ferrooxidans), AF1, AF2, AF3 and AFc, were isolated from samples with different geological sources using a 9K medium. These four isolates were identified as A...
  49. doi Purification and characterization of antifungal δ-dodecalactone from Lactobacillus plantarum AF1 isolated from kimchi
    E J Yang
    Department of Food and Nutrition, Kimchi Research Center, Chosun University, 375 Seosuk dong, Dong Gu, Gwangju 501 759, Republic of Korea
    J Food Prot 74:651-7. 2011
    The aim of this study was to purify and identify an antifungal compound from Lactobacillus plantarum AF1, which was isolated from kimchi...
  50. ncbi The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands
    S Park
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    Oncogene 14:533-42. 1997
    ..Three different GPI-linked ligands, namely Elf-1/Cek7-L, Ehk1-L/Efl-2/Lerk3 and AL-1/RAGS, were isolated from mouse brain...
  51. ncbi Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization
    W Yu
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021, USA
    Nature 400:682-7. 1999
    ..immature B cells in the bone marrow that undergo receptor editing express V(D)J-recombination-activating genes (RAGs)...
  52. ncbi Can caregivers independently rate cognitive and behavioral symptoms in Alzheimer's disease patients?: A longitudinal analysis
    C G Ippen
    Department of Psychology, University of Southern California, Los Angeles, USA
    Am J Geriatr Psychiatry 7:321-30. 1999
    ..patients (N=153) and their caregivers over 1 year with the Relative's Assessment of Global Symptomatology-Elderly (RAGS-E) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADASc)...
  53. pmc A ligand binding domain mutation in the mouse glucocorticoid receptor functionally links chromatin remodeling and transcription initiation
    L A Sheldon
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Mol Cell Biol 19:8146-57. 1999
    ..process and in the functional significance of the two major transcriptional activation domains, AF1 and AF2...
  54. ncbi The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression
    Hany Abdel-Hafiz
    Department of Medicine, Molecular Biology Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Biol Chem 277:33950-6. 2002
    ..ubiquitin-like modifier (SUMO-1) protein consensus-binding motif, (387)IKEE, located in the N terminus upstream of AF1. Self-squelching does not involve this site...
  55. ncbi DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two nuclear receptors?
    D Obradovic
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Pharmacol 65:761-9. 2004
    ..We therefore performed a yeast-two-hybrid screening of a human brain cDNA library with an AF1-containing region of the human MR as bait...
  56. ncbi Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:1081-9; discussion 1090-1. 2004
    ..beta A [INHBA] and CD29) and/or at the transcript level by RT-PCR (INHBA, AKAP12, ELK3, FOXQ1, EIF5A2, and EFNA5)...
  57. ncbi Human papillomavirus type 16 E2 and E6/E7 variants
    David C Swan
    U S Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30333, USA
    Gynecol Oncol 96:695-700. 2005
    ....
  58. pmc Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations
    Derek N Lavery
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Biochem J 391:449-64. 2005
    ..Recent evidence supports a structural and functional model for the NTD that involves induced folding, possibly involving alpha-helix structure, in response to protein-protein interactions and structure-stabilizing solutes...
  59. ncbi Comparative integromics on Ephrin family
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 15:1391-5. 2006
    EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2 and EFNB3 are EFN family ligands for EPH family receptors. EFN/EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis...
  60. ncbi The role of the general transcription factor IIF in androgen receptor-dependent transcription
    M Ansar Choudhry
    School of Medical Sciences, Institute of Medical Sciences Building, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Mol Endocrinol 20:2052-61. 2006
    ..The major transactivation function of the AR, termed activation function 1 (AF1), is modular in structure and has been mapped to the N terminus of the protein...
  61. ncbi Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen
    Dieter Kressler
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 282:26897-907. 2007
    ..Our findings suggest that tamoxifen-induced changes in the ERalpha LBD promote interactions with the coactivator PGC-1beta, which then cooperates with SRC-1 to enable tamoxifen agonism...
  62. ncbi Aberrant V(D)J cleavages in T cell receptor beta enhancer- and p53-deficient lymphoma cells
    Yun Hee Kang
    Institute of Bioscience, Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea
    Oncol Rep 23:1463-8. 2010
    ..Recombination activation genes (RAGs) were expressed, while the TCRbeta chain was not expressed in the EP cell lines...
  63. ncbi Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats
    Kavita Pabreja
    Department of Life Sciences, International Medical University, KL, Malaysia
    Curr Drug Deliv 7:324-8. 2010
    ..5 degrees C) 4 h after carrageenan injection. Topical application of AF1 significantly attenuated the development of hypersensitivity to thermal stimulus as compared to control (P<0...
  64. doi EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability
    Tong Hong Wang
    Tissue Bank, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    FEBS J 279:251-63. 2012
    ..In conclusion, ephrinA5 inhibited colon cancer progression by promoting c-Cbl-mediated EGFR degradation. Our findings identify a novel mechanism that could be utilized to improve the therapeutic efficiency of EGFR-targeting strategies...
  65. pmc Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2
    Sebastien A Gauthier
    Department of Biology, University of Oklahoma, Norman, Oklahoma, United States of America
    PLoS Genet 8:e1002883. 2012
    ..explains some of the differences in transcriptional properties that are displayed by the EcR isoforms, and similar interactions may underlie the differential activities of other nuclear receptors with distinct AF1-coactivators.
  66. pmc Estrogen dependent activation function of ERβ is essential for the sexual behavior of mouse females
    Maria Cristina Antal
    Institut d Histologie, Faculte de Medecine, Universite de Strasbourg, 67085 Strasbourg, France
    Proc Natl Acad Sci U S A 109:19822-7. 2012
    ..Decreased attractivity is also exhibited by ERβAF2(0) but not by ERβAF1(0) mutant females (females devoid of either AF2 or AF1 activation function of ERβ)...
  67. doi Rheb and Rags come together at the lysosome to activate mTORC1
    Marlous J Groenewoud
    Molecular Cancer Research, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem Soc Trans 41:951-5. 2013
    ..The activity of mTOR is under the control of various GTPases, of which Rheb and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity...
  68. doi A TFG-TEC nuclear localization mutant forms complexes with the wild-type TFG-TEC oncoprotein and suppresses its activity
    Bobae Lim
    Laboratory of Molecular and Cellular Biology, Department of Life Sciences, Sogang University, Seoul 121 742, South Korea
    Biochem J 456:361-72. 2013
    ..protein self-associates, and that this is dependent upon the CC (coiled-coil) domain (amino acids 97-124), the AF1 (activation function 1) domain (amino acids 275-562) and the DBD (DNA-binding domain) (amino acids 563-655)...
  69. pmc The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
    Zhi Yang Tsun
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center, Cambridge, MA 02142, USA Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 52:495-505. 2013
    ..The Rags are unusual GTPases in that they function as obligate heterodimers, which consist of RagA or B bound to RagC or D...
  70. doi Expression of key lipid metabolism genes in adipose tissue is not altered by once-daily milking during a feed restriction of grazing dairy cows
    T M Grala
    DairyNZ Ltd, c o University of Auckland, 3 Symonds St, Auckland 1010, New Zealand Electronic address
    J Dairy Sci 96:7753-64. 2013
    ..carboxylase (PC)], and triacylglyceride synthesis [diacylglycerol O-acyltransferase 2 (DGAT2)] were greater in AF1× cows compared with all other treatments...
  71. pmc RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells
    Bradley S Gordon
    The Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, PO Box 850, Hershey, PA 17033, USA
    Cell Signal 26:461-7. 2014
    ..The activation state of mTORC1 is regulated by a variety of GTPases including Rheb and Rags. Recently, Rho1, the yeast ortholog of RhoA, was shown to interact directly with TORC1 and repress its activation ..
  72. pmc An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1
    Yanni Zhang
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 111:397-402. 2014
    ..receptors in the vertebrate immune system is generated via proteins encoded by the recombination activating genes (RAGs) RAG1 and RAG2 by a process known as variable, diversity, and joining [V(D)J] gene recombination...
  73. doi Spinal cord injury and the neuron-intrinsic regeneration-associated gene program
    Nitish D Fagoe
    Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Neuromolecular Med 16:799-813. 2014
    ..This response consists of the expression of many RAGs, including regeneration-associated transcription factors (TFs)...
  74. doi Mutational screening of EFNA5 in Chinese age-related cataract patients
    Qinghong Lin
    Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China
    Ophthalmic Res 52:124-9. 2014
    In the past few years, Ephrin-A5 (EFNA5) had been identified to be associated with lens development, but so far no sequence variation in EFNA5 has been reported in humans...
  75. pmc Exercise dependent increase in axon regeneration into peripheral nerve grafts by propriospinal but not sensory neurons after spinal cord injury is associated with modulation of regeneration-associated genes
    Rahul Sachdeva
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Exp Neurol 276:72-82. 2016
    ..in regenerative response is associated with changes in levels of mRNAs encoding the regeneration associated genes (RAGs) GAP43, β-actin and Neuritin...
  76. doi Incorporation of Jahn-Teller Cu(2+) Ions into Magnetoelectric Multiferroic MnWO4: Structural, Magnetic, and Dielectric Permittivity Properties of Mn1-xCuxWO4 (x ≤ 0.25)
    Pascaline Patureau
    Institut des Materiaux Jean Rouxel IMN, Universite de Nantes, CNRS UMR 6502, 2 rue de la Houssiniere, F 44300 Nantes, France
    Inorg Chem 54:10623-31. 2015
    ..Magnetic susceptibility reveals that only 5% of Cu substitution suppresses the nonpolar collinear AF1 antiferromagnetic structure observed in pure MnWO4...
  77. pmc Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae
    Jeremy Worley
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, 85721 0206
    G3 (Bethesda) 6:463-74. 2015
    ..cells have shown that nitrogen/amino acid starvation signals act through Npr2/Npr3 and the small GTPases Gtr1/Gtr2 (Rags in humans) to inhibit TORC1...
  78. doi Changes in shape and size of the stiff branched β-glucan in dimethlysulfoxide/water solutions
    Shuqin Xu
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China
    Carbohydr Polym 138:86-93. 2016
    The conformation transition of the short branched β-glucan AF1 isolated from Auricularia auricula-judae in DMSO/water solutions was investigated with viscometry and static/dynamic light scattering (SLS/DLS)...
  79. doi Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia
    Sarah Weckhuysen
    INSERM, U1127, ICM, Paris, France
    Epilepsia 57:994-1003. 2016
    ..DEPDC5 is part of a complex named GAP activity toward RAGs (GATOR) complex 1 (GATOR1), together with the proteins NPRL2 and NPRL3, and acts to inhibit the mechanistic target ..
  80. pmc Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration
    Sudheendra N R Rao
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine Miami, FL, USA
    Front Mol Neurosci 9:33. 2016
    ..extrinsic factors adversely affect the gene programs that govern the expression of regeneration-associated genes (RAGs) and the production of a diversity of extracellular matrix molecules (ECM)...
  81. pmc Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration
    Yong Hwee Eddie Loh
    a Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Epigenetics . 2016
    ..5hmC was altered in a large set of regeneration-associated genes (RAGs), including well-known RAGs, such as Atf3, Bdnf, and Smad1, that regulate axon growth potential of DRG neurons, ..
  82. ncbi Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness
    Eric Batsche
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Biol Chem 280:19746-56. 2005
    ..Although recruitment of SRC/p160 coactivators to the NGFI-B AF1 domain is independent of Rb, its presence enhances SRC-dependent transcription...
  83. ncbi Distribution of ether in two postmortem cases
    Dawn Cox
    Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, 1413 Research Blvd, Bldg 102, Rockville, Maryland 20850, USA
    J Anal Toxicol 30:635-7. 2006
    ..Two saturated rags and a resealable bag containing a clear liquid were contained within these trash bags...
  84. doi Niphatenones, glycerol ethers from the sponge Niphates digitalis block androgen receptor transcriptional activity in prostate cancer cells: structure elucidation, synthesis, and biological activity
    Labros G Meimetis
    Department of Chemistry and Earth, University of British Columbia, 2036 Main Mall, Vancouver, B C, Canada V6T 1Z1
    J Med Chem 55:503-14. 2012
    ..Use of the propargyl ether 44 and Click chemistry showed that niphatenone B binds covalently to the activation function-1 (AF1) region of the AR N-terminus domain (NTD).
  85. ncbi Recent advances in diagnosis of filarial infections
    R Chandrashekar
    Heska Corporation, Fort Collins, CO 80525, USA
    Indian J Exp Biol 35:18-26. 1997
    ..Recombinant antigens (rAgs) are available today which detect prepatent infections in onchocerciasis...
  86. ncbi Further characterization of the glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. The role of the glucocorticoid receptor-binding sites
    D K Scott
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Mol Endocrinol 12:482-91. 1998
    ..through a complex glucocorticoid response unit that consists of, from 5' to 3', accessory factor elements AF1 and AF2; two noncanonical glucocorticoid receptor-binding sites, GR1 and GR2; a third accessory factor element, AF3;..
  87. ncbi Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7
    D Chen
    Department of Cancer Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, United Kingdom
    Mol Cell 6:127-37. 2000
    Phosphorylation of the estrogen receptor alpha (ERalpha) N-terminal transcription activation function AF1 at serine 118 (S118) modulates its activity...
  88. ncbi Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351
    J MacGregor Schafer
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cancer Res 60:5097-105. 2000
    ..alpha (ER) and silences activating function 2 (AF2) in the ligand binding domain, but activating function 1 (AF1) at the other end of the ER remains constitutive and is considered to be ligand independent...
  89. ncbi Toxicology of environmental estrogens
    S H Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Reprod Fertil Dev 13:307-15. 2001
    ..The SERMs differentially activate wild-type ERalpha and variant forms expressing activation function 1 (ER-AF1) and AF2 (ER-AF2) in human HepG2 hepatoma cells transfected with a pC3-luciferase construct, and these in vitro ..
  90. ncbi Pre-erythrocytic antigens of Plasmodium falciparum: from rags to riches?
    Anne Charlotte Gruner
    Unité de Parasitologie Biomédicale, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Trends Parasitol 19:74-8. 2003
    ..Here, current knowledge of pre-erythrocytic antigens is updated in the light of recent results, and the post-genomic prospects of completing the antigenic repertoire of these immunologically important and intriguing stages is discussed...
  91. ncbi The naturally occurring variant of estrogen receptor (ER) ERDeltaE7 suppresses estrogen-dependent transcriptional activation by both wild-type ERalpha and ERbeta
    Juana M García Pedrero
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncología Principado de Asturias, Universidad de Oviedo, 33071 Oviedo, Spain
    Endocrinology 144:2967-76. 2003
    ..triggered by epithelial growth factor and phorbol-12-myristate-13-acetate is also abolished in ERDeltaE7 despite AF1 integrity, suggesting a cross-talk between AF1 and AF2 regions of the receptor...
  92. ncbi Peripheral blood lymphocytes express recombination-activating genes 1 and 2 during Epstein-Barr virus-induced infectious mononucleosis
    Hans Joachim Wagner
    Center for Molecular and Tumor Virology, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    J Infect Dis 190:979-84. 2004
    ..for secondary immunoglobulin gene rearrangement, we examined the expression of the recombination-activating genes (RAGs) in peripheral blood mononuclear cells (PBMCs) from 26 patients with infectious mononucleosis (IM)...
  93. ncbi Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand specificity
    Anca D Petrescu
    Department of Physiology and Pharmacology, Texas A and M University, Texas Veterinary Medical Center, College Station 77843 4467, USA
    J Biol Chem 280:16714-27. 2005
    ..ii) Deleting the N-terminal A-D-domains, comprising the AF1 and DNA binding functions, only slightly affected affinities for LCFA-CoAs (Kd=0.9-4 nm) and LCFAs (Kd=93-581 nm)...
  94. ncbi Gene regulation by the glucocorticoid receptor: structure:function relationship
    Raj Kumar
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1068, USA
    J Steroid Biochem Mol Biol 94:383-94. 2005
    ..Not much is known about the structure of the NTD, which contains the powerful AF1/tau1/enh2 transactivation region...
  95. pmc ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors
    V Duong
    INSERM U540 Molecular and Cellular Endocrinology of Cancers, 34090 Montpellier, France
    Oncogene 25:1799-806. 2006
    ..The use of deletion mutants of both receptors demonstrated that AF1 domain of the receptors was required...
  96. ncbi DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling
    Gary M Wilson
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Suite 100, 570 West 7th Avenue, Vancouver, BC, Canada V5Z 4S6
    Hum Mol Genet 15:743-9. 2006
    ..These aberrant loci contained the genes encoding EFNA5, GLUR7, CACNG2 and AKAP5; all brain-expressed proteins with known or postulated roles in neuronal function, and ..
  97. ncbi Comparison of standard radiological risk models and using RESRAD to derive generic risk-based area factors for final status surveys
    David A King
    Science Applications International Corporation, Oak Ridge, TN 37831, USA
    Risk Anal 26:175-83. 2006
    ..ingestion, inhalation, and direct gamma intake equations used by RESRAD, Risk Assessment Guidance for Superfund (RAGS), and the Soil Screening Guidance for Radionuclides (SSG) are similar and can produce similar results, but there ..
  98. doi Structural characterization of the native NH2-terminal transactivation domain of the human androgen receptor: a collapsed disordered conformation underlies structural plasticity and protein-induced folding
    Derek N Lavery
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Biochemistry 47:3360-9. 2008
    ..is less well structurally defined and contains the main determinants for receptor-dependent transactivation, termed AF1. Previously, we have shown this region has the propensity to form alpha-helix structure...
  99. pmc SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions
    Adam Raymond
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Cell Biochem 106:957-66. 2009
    ..identified in many species and by many investigators and given a variety of names, including p47, lactadherin, rAGS, PAS6/7, and BA-46...
  100. doi Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1
    Laura MacPherson
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ont, Canada
    Biochem Biophys Res Commun 385:263-8. 2009
    We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells...

Research Grants34

  1. Structural and functional studies of the nuclear receptor PPARgamma
    H Eric Xu; Fiscal Year: 2010
    ..PPAR? also contains a potent N- terminal activation domain, AF1. Until recently, structures were available only for the isolated PPAR? LBD bound to diverse synthetic ligands and ..
  2. BIOCHEMISTRY AND REGULATION OF V(D)J RECOMBINATION
    Mark S Schlissel; Fiscal Year: 2012
    ..The RAGs first nick the DNA then introduce dsDNA breaks...
  3. GWEN BUEL; Fiscal Year: 2015
    ..proposes that the Rag proteins localize to the lysosomal membrane constitutively, our data demonstrate that the Rags diffuse away from the lysosomes following amino acid stimulation. Due to the timing of mTORC1 localization vs...
  4. Spatiotemporal Comparison of Aberrant & Ectopic VDJ Recombination Events In Vivo
    PENNY ELLEN SHOCKETT; Fiscal Year: 2010
    ..in the development of other types of tumors has been proposed, but more studies are needed to understand if RAGs cause detrimental gene rearrangements in nonlymphoid cells...
  5. John Blenis; Fiscal Year: 2016
    ..GEFs in mTORC1 activation (aim #1);define how and why AAs regulate the Ran gradient and the nuclear entry of Rags and/or mTORC1 (aim #2);and identify new molecular details of how mTORC1 regulates mRNA biogenesis (aim #3)...
  6. Ruikang Wang; Fiscal Year: 2015
    ..g. rags) in the Wang Lab...
  7. Zhi Yang Tsun; Fiscal Year: 2014
    ..We propose the following aims: 1) Characterize the FLCN interaction and localization with the Rags and Ragulator complex under different nutrient conditions...
  8. INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEM
    DAN CORNELL; Fiscal Year: 1993
    ..Scale (CGI), Hamilton Rating Scale for Depression, Relatives' Assessment of Global Symptomatology-Elderly (RAGS-E), the Physical Self-Maintenance Scale and Instrumental Activities of Daily Living (PSMS/IADL)...
  9. New models for RAG-mediated lymphomagenesis
    SANDRA SALUS; Fiscal Year: 2004
    ..The nicked DNA intermediates generated by RAGs during cleavage have not been thought to be particularly dangerous even though unpaired RSSs as well as RSS-like ..
  10. EPH MOLECULES IN HIPPOCAMPAL TOPOGRAPHIC PROJECTIONS
    Renping Zhou; Fiscal Year: 1999
    ..First, he will inject a soluble eph ligand, A1-1/RAGS, which serves as an inhibitor for Bsk or related receptors, into developing mouse brain...
  11. STOP SIGNALS FOR NEURONAL MIGRATION IN CEREBRAL CORTEX
    Eva Anton; Fiscal Year: 2004
    ..cortex, we identified a putatively novel radial glial cell surface molecule (Radial Glial Stop Signal molecule: RAGS 1) whose temporal and spatial distribution during cortical development in regions where neurons terminate their ..
  12. Structure/Function of Steroid Receptor AF1 Coregulators
    JORGE INIGUEZ LLUHI; Fiscal Year: 2006
    ..GR harbors two major transcriptional activation functions (AF1 and AF2) that are differentially utilized in individual promoter and cellular contexts...
  13. Structure:function studies of the glucocorticoid receptor
    Raj Kumar; Fiscal Year: 2007
    ..Until recently, it was difficult to determine AF1 structure because in solution it exists as a random ensemble of conformers...
  14. INTERFERON GAMMA RECEPTORS--REGULATION AND FUNCTION
    Sidney Pestka; Fiscal Year: 2000
    ..to determine the role of the second interferon gamma receptor chain, gR2, in various responses; and 7. to identify additional accessory factors beyond AF1 (now called gamma R2) involved in the action of gamma interferon.
  15. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..ERalpha/Spl-mediated gene expression is dependent, in part, on activation function 1 (AF1) of ERalpha and preliminary studies show the p160 steroid receptor coactivators (SRCs) do not enhance Eralpha/Spl ..
  16. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  17. HUMAN V(D)J RECOMBINASE IN NEOPLASTIC AND PRIMARY CELLS
    Michael Lieber; Fiscal Year: 2004
    ..Corresponding studies of such regions on minichromosomes will permit the testing of the effects of the direction of DNA replication and transcription. ..
  18. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  19. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  20. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  21. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  22. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  23. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  24. c-Abl and PKC-eta in Cell Development and Leukemia
    Mark Schlissel; Fiscal Year: 2008
    ..abstract_text> ..
  25. Structure Study of Angiopoietins and the Tie2 Receptor
    Dimitar Nikolov; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  26. Characterization of V(D)J cleavage and repair complexes
    PATRICK SWANSON; Fiscal Year: 2007
    ..abstract_text> ..
  27. Structural Study of Semaphorins, Neuropilins and Plexins
    Dimitar Nikolov; Fiscal Year: 2009
    ..abstract_text> ..
  28. Protein-DNA Interactions in V(D)J Recombination
    Karla Rodgers; Fiscal Year: 2007
    ..Results from these studies will provide a valuable framework in the determination of the assembly and mechanism of the V(D)J recombinase. ..
  29. BIOCHEMISTRY AND REGULATION OF V (D) J RECOMBINATION
    Mark Schlissel; Fiscal Year: 2004
    ....
  30. Role of sex steroids in female TIEG-null mouse bone loss
    John Hawse; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  31. EPH MOLECULES IN OTOGENY OF BRAIN REWARD CIRCUITS
    Renping Zhou; Fiscal Year: 2001
    ..Understanding the molecular basis governing the axonal connections and modifications may shed new light on the underlying mechanism of drug addiction, as well as diseases involving this system such as Parkinson's disease. ..
  32. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..
  33. Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
    Dimitar Nikolov; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..