EDARADD

Summary

Gene Symbol: EDARADD
Description: EDAR associated death domain
Alias: ECTD11A, ECTD11B, ED3, EDA3, ectodysplasin-A receptor-associated adapter protein, EDAR-associated death domain protein, crinkled homolog, ectodysplasia A receptor associated death domain
Species: human

Top Publications

  1. ncbi The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes
    Asma Smahi
    Département de Génétique et Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM UR 393, Hopital Necker, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Hum Mol Genet 11:2371-5. 2002
  2. ncbi Interleukin-4 ameliorates crescentic glomerulonephritis in Wistar Kyoto rats
    H T Cook
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, England, United Kingdom
    Kidney Int 55:1319-26. 1999
  3. doi Mutation screening of the Ectodysplasin-A receptor gene EDAR in hypohidrotic ectodermal dysplasia
    Annemarie H van der Hout
    Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Hum Genet 16:673-9. 2008
  4. ncbi Cloning, expression, and mutagenesis of trypsin inhibitor ETIb from Erythrina variegata seeds
    Y Kouzuma
    Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 61:1041-3. 1997
  5. ncbi Expression and function of sialoadhesin in rat alveolar macrophages
    K Frei
    Institute of Histology and Embryology, University of Vienna, Schwarzspanierstrasse 17, A 1090, Vienna, Austria
    Immunol Lett 71:167-70. 2000
  6. pmc A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13
    L Ho
    Department of Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    Am J Hum Genet 62:1102-6. 1998
  7. ncbi Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus
    E Bal
    INSERM U781 et Département de Génétique, Hopital Necker Enfants Malades, Paris, France
    Hum Mutat 28:703-9. 2007
  8. ncbi Mapping of a ligand-binding site for the human thromboxane A2 receptor protein
    Joseph W Turek
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 277:16791-7. 2002
  9. ncbi Immunohistochemical characterization of macrophage and dendritic cell subpopulations of the spleen, thymus, tongue and heart in cyclophosphamide-induced immunosuppressed rat
    S Yoon
    Department of Anatomy, College of Medicine, Pusan National University, Pusan, South Korea
    Anat Histol Embryol 32:80-8. 2003
  10. pmc Involvement of the Edar signaling in the control of hair follicle involution (catagen)
    Michael Y Fessing
    Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA 02118, USA
    Am J Pathol 169:2075-84. 2006

Research Grants

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes
    Asma Smahi
    Département de Génétique et Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM UR 393, Hopital Necker, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Hum Mol Genet 11:2371-5. 2002
    ..involved in NF-kappaB activation: ectodysplasin (EDA1), EDA-receptor (EDAR) and EDAR-associated death domain (EDARADD)...
  2. ncbi Interleukin-4 ameliorates crescentic glomerulonephritis in Wistar Kyoto rats
    H T Cook
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, England, United Kingdom
    Kidney Int 55:1319-26. 1999
    ..Interleukin-4 (IL-4) down-regulates many macrophage proinflammatory activities. We therefore studied the effect of IL-4 on glomerular injury in a model of crescentic glomerulonephritis in the Wistar Kyoto rat...
  3. doi Mutation screening of the Ectodysplasin-A receptor gene EDAR in hypohidrotic ectodermal dysplasia
    Annemarie H van der Hout
    Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Hum Genet 16:673-9. 2008
    ..ectodysplasin A (ED1) gene or the autosomal ectodysplasin A-receptor (EDAR) and EDAR-associated death domain (EDARADD) genes. X-linked and autosomal forms are sometimes clinically indistinguishable...
  4. ncbi Cloning, expression, and mutagenesis of trypsin inhibitor ETIb from Erythrina variegata seeds
    Y Kouzuma
    Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 61:1041-3. 1997
    ..the mature form of ETIb was introduced into an expression vector, pET-22b, and expressed in Escherichia coli BL21 (ED3) in a functional form...
  5. ncbi Expression and function of sialoadhesin in rat alveolar macrophages
    K Frei
    Institute of Histology and Embryology, University of Vienna, Schwarzspanierstrasse 17, A 1090, Vienna, Austria
    Immunol Lett 71:167-70. 2000
    ..demonstrated on murine and rat mφ in lymphatic organs and is recognised by the monoclonal antibody (mAb) ED3 in the rat...
  6. pmc A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13
    L Ho
    Department of Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    Am J Hum Genet 62:1102-6. 1998
    ..By genetic linkage analysis of a large ADHED kindred, we have mapped a gene for ADHED (EDA3) to the proximal long arm of chromosome 2 (q11-q13)...
  7. ncbi Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus
    E Bal
    INSERM U781 et Département de Génétique, Hopital Necker Enfants Malades, Paris, France
    Hum Mutat 28:703-9. 2007
    ..In addition, mutations in a recently identified gene, EDARADD, encoding EDAR-associated death domain (EDARADD) have been shown to cause autosomal recessive EDA...
  8. ncbi Mapping of a ligand-binding site for the human thromboxane A2 receptor protein
    Joseph W Turek
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 277:16791-7. 2002
    ..that ligands interact with amino acids contained within the C-terminal portion of the third extracellular domain (ED3) of the receptor protein...
  9. ncbi Immunohistochemical characterization of macrophage and dendritic cell subpopulations of the spleen, thymus, tongue and heart in cyclophosphamide-induced immunosuppressed rat
    S Yoon
    Department of Anatomy, College of Medicine, Pusan National University, Pusan, South Korea
    Anat Histol Embryol 32:80-8. 2003
    ..After CY treatment, remarkably, ED1+, ED2+ and ED3+ macrophage subpopulations, in general exhibited signs of cellular activation such as an increase in number and ..
  10. pmc Involvement of the Edar signaling in the control of hair follicle involution (catagen)
    Michael Y Fessing
    Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA 02118, USA
    Am J Pathol 169:2075-84. 2006
    ..Here, we show that during the murine hair cycle the expression of Eda A1, Edar, Edaradd, and TRAF6 transcripts are minimal in the resting phase and maximal during HF transition from active growth to ..
  11. pmc The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3
    C D Dijkstra
    Immunology 54:589-99. 1985
    ..ED2 and ED3 recognize membrane antigens of tissue macrophages, discriminating between distinct subpopulations of macrophages, ..
  12. ncbi Enhanced intimal proliferation upon injury to pre-existing neointima and resistance of neointimal cells to cell death
    L M Myllärniemi
    Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Finland
    Cardiovasc Pathol 8:339-47. 1999
    ..immunoreactivity, compared to the first injury at corresponding time points, followed by high numbers of activated ED3+ macrophages and CD4+ T cells in the developing neointima...
  13. ncbi Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis
    Heather M Wilson
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Mol Ther 6:710-7. 2002
    ..IL-10 treatment decreased the number of glomerular ED1- and ED3-positive cells, MHC class II expression, and the number of fibrinoid lesions...
  14. ncbi Effects of lipopolysaccharide on the appearance of macrophage populations and fibrogenesis in cisplatin-induced rat renal injury
    Jyoji Yamate
    Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1 1, Sakai, Osaka 599 8531, Japan
    Exp Toxicol Pathol 56:13-24. 2004
    ..Cells immunoreactive for ED1 (for exudate macrophages), ED2 (for resident macrophages) and ED3 (for activated resident macrophages) showed the highest number on day 4 or day 7, and thereafter, the numbers were ..
  15. ncbi The ectodysplasin pathway in feather tract development
    Leslie Houghton
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 132:863-72. 2005
    ..pathway, comprising the ligand ectodysplasin, its receptor Edar and a dedicated death domain adaptor protein Edaradd, plays an important role in epidermal organ formation in mammals...
  16. ncbi Protective immunity of E. coli-synthesized NS1 protein of Japanese encephalitis virus
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, ROC
    Biotechnol Lett 30:205-14. 2008
    ..coli-synthesized NS1 protein with another protective immunogen, the envelope domain III (ED3). Pre-challenge, detectable titers of JEV-specific neutralizing antibody were detected in the immunized mice with E...
  17. doi Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA
    Diana Ludolfs
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20356 Hamburg, Germany
    J Clin Virol 45:125-8. 2009
    In contrast to most antibodies directed to the envelope glycoprotein of flaviviruses, those to the domain III (ED3) show serotype-specific reactions.
  18. doi From ectodermal dysplasia to selective tooth agenesis
    Gabriele I Mues
    Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Am J Med Genet A 149:2037-41. 2009
    ..that phenotypically identical syndromes (HED) can be caused by mutations in different genes (EDA, EDAR, EDARADD), that mutations in the same gene (EDA) can lead to different phenotypes (HED and selective tooth agenesis) and ..
  19. pmc Structure of yellow fever virus envelope protein domain III
    David E Volk
    Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1157, USA
    Virology 394:12-8. 2009
    ..Variations in the structure and surface chemistry of ED3 between flaviviruses affect neutralization sites and may affect host cell receptor interactions and play a role in ..
  20. doi Estradiol limits viral replication following intravaginal immunization leading to diminished mucosal IgG response and non-sterile protection against genital herpes challenge
    Amy Gillgrass
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Am J Reprod Immunol 63:299-309. 2010
    ..In this study, we determined the outcome of immunization after the thickening of vaginal epithelium following E-treatment waned. OVX, C57BL/6 mice were given Progesterone (P), E or saline (S) for 3 days and immunized with IVAG TK-HSV-2...
  21. ncbi Oligodontia ectodermal dysplasia--on signs, symptoms, genetics, and outcomes of dental treatment
    Birgitta Bergendal
    Department of Odontology, Umea University, Umeå 2010
    Swed Dent J Suppl . 2010
    ..Sequence alterations predicted to be damaging or potentially damaging were revealed in the AXIN2, MSX1, PAX9, and EDARADD genes in 14 (15%) of the probands. All mutations but one were novel...
  22. pmc Epigenetic predictor of age
    Sven Bocklandt
    Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e14821. 2011
    ..The methylation of three sites--in the promoters of the EDARADD, TOM1L1, and NPTX2 genes--is linear with age over a range of five decades...
  23. doi The ectodysplasin pathway: from diseases to adaptations
    Alexa Sadier
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, Centre National de la Recherche Scientifique CNRS, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Trends Genet 30:24-31. 2014
    ..that belongs to the tumor necrosis factor (TNF)-α family, EDAR, a receptor related to the TNFα receptors, and EDARADD, a specific adaptor. This core pathway relies on downstream NF-κB pathway activation to regulate target genes...
  24. ncbi [Rickets-like genetic diseases]
    Hong Wei Ma
    Department of Developmental Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China
    Zhongguo Dang Dai Er Ke Za Zhi 15:923-7. 2013
    ..Children with ectodermal dysplasia may see a doctor for sparse hair, and they are easily misdiagnosed with nutritional vitamin D deficiency rickets. Ectodermal dysplasia is related to EDA, EDAR, EDARADD and WNT 10A genes.
  25. doi Computational prediction and experimental characterization of a "size switch type repacking" during the evolution of dengue envelope protein domain III (ED3)
    Montasir Elahi
    Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Nakamachi, Koganei Shi, Tokyo 184 8588, Japan
    Biochim Biophys Acta 1844:585-92. 2014
    ..Here, we aim at characterizing the thermodynamic stability of DEN envelope protein domain III (ED3) during its evolution, and we report a structural analysis of DEN4wt ED3 combined with a systematic mutational ..
  26. doi Novel missense mutations in the AXIN2 gene associated with non-syndromic oligodontia
    Singwai Wong
    Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
    Arch Oral Biol 59:349-53. 2014
    ..To date, mutations in EDA, AXIN2, MSX1, PAX9, WNT10A, EDAR, EDARADD, NEMO and KRT 17 are known to associate with non-syndromic oligodontia...
  27. doi Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line
    Helen M Campanha
    Rutgers, New Jersey Medical School Graduate School of Biomedical Sciences, 185 South Orange Avenue, MSB H609, Newark, NJ 07103, United States Electronic address
    Toxicol Lett 230:122-31. 2014
    ..cell adhesion, proliferation and neuritogenesis, in the presence and absence of human red blood cell (hRBC) AChE (ED3.1.1.7). AChE active-site inhibitor paraoxon (PO; 0.1-1...
  28. doi Development of a multiplex bead-based assay to monitor dengue virus seroconversion
    Kaiting Ng
    Singapore Immunology Network SIgN, A STAR, 8A Biomedical Grove, Singapore, Singapore
    Methods Mol Biol 1138:53-74. 2014
    ..The ED3 domain of a specific DENV serotype is cloned into pQEAM containing 6xHIS, TEV protease, and AviTag biotinylation ..
  29. pmc Thermodynamic mechanism for the evasion of antibody neutralization in flaviviruses
    Rodrigo A Maillard
    Department of Biochemistry and Molecular Biology, Department of Microbiology and Immunology, Department of Pathology, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity and Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas 77555, United States
    J Am Chem Soc 136:10315-24. 2014
    ..We applied this method to the envelope protein domain III (ED3) of two medically important flaviviruses: West Nile and dengue 2...
  30. ncbi Identification of potential targets for thylakoid oxidoreductase AtVKOR/LTO1 in chloroplasts
    Ying Lu
    College of Life Science, Shandong Agricultural University, Shandong Taian 271000, People s Republic of China
    Protein Pept Lett 22:219-25. 2014
    ..with AtVKOR, including HCF164, cytochrome c6A, violaxanthin deepoxidase, embryo sac development arrest 3 protein (EDA3), two members pentapeptide repeat proteins (TL17 and TL20.3), and two FK-506 binding proteins (FKBP13 and FKBP20-2)...
  31. pmc Selection and Characterization of DNA Aptamers Targeting All Four Serotypes of Dengue Viruses
    Heng Li Chen
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan
    PLoS ONE 10:e0131240. 2015
    ..Enrichment (SELEX), we demonstrated the first aptamer (S15) that can bind to DENV-2 envelop protein domain III (ED3) with a high binding affinity...
  32. pmc Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD
    Alexa Sadier
    Institut de Génomique Fonctionnelle de Lyon, UMR 5242 du CNRS, Universite de Lyon, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364, Lyon, Cedex 07, France
    BMC Evol Biol 15:129. 2015
    ..We investigate here the role of gain and loss of isoforms using Edaradd, a gene of the Ecodysplasin pathway, implicated in morphological evolution...
  33. doi Structural and biophysical analysis of sero-specific immune responses using epitope grafted Dengue ED3 mutants
    Manjiri R Kulkarni
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184 8588, Japan
    Biochim Biophys Acta 1854:1438-43. 2015
    ..The third domain of the viral envelope protein (ED3) contains the two major putative epitopes and is a highly suitable model protein for examining the molecular ..
  34. doi Emu oil decreases atherogenic plaque formation in cafeteria diet-induced obese rats
    Soundararajan Kamalakkannan
    Department of Zoology, Bishop Heber College, Puthur, Tiruchirappalli 620017, India
    J Sci Food Agric 96:3063-8. 2016
    ..groups (n = 6), and fed with normal diet (chow pellet; ND), or with cafeteria diet (CD), or with CD along with emu oil supplementation at three different doses: ED1 (2 mL), ED2 (4 mL) and ED3 (8 mL) kg(-1) body weight (BW), respectively.
  35. doi GREMLIN 2 Mutations and Dental Anomalies
    P N Kantaputra
    Center of Excellence in Medical Genetics Research, Chiang Mai University, Chiang Mai, Thailand Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand Dentaland Clinic, Chiang Mai, Thailand
    J Dent Res 94:1646-52. 2015
    ..It has been associated with mutations in MSX1, PAX9, EDA, AXIN2, EDAR, EDARADD, and WNT10A...
  36. pmc Characterization of a Novel Dengue Serotype 4 Virus-Specific Neutralizing Epitope on the Envelope Protein Domain III
    Guang Hui Ji
    Department of Traditional Chinese Medicine, Navy General Hospital, Beijing, China International Joint Cancer Institute, Second Military Medical University, Shanghai, China
    PLoS ONE 10:e0139741. 2015
    The dengue virus (DENV) envelope protein domain III (ED3) has been suggested to contain receptor recognition sites and the critical neutralizing epitopes...
  37. doi Novel missense mutation in the EDA gene in a family affected by oligodontia
    Gisela Ruiz-Heiland
    Department of Orthodontics, Justus Liebig University of Giessen, Schlangenzahl 14, 35392, Giessen, Germany
    J Orofac Orthop 77:31-8. 2016
    Mutations in the EDA-EDAR-EDARADD genes and more recently, mutations in the WNT10A gene have been described as the cause of syndromic and nonsyndromic tooth agenesis concomitant with diverse abnormalities of ectodermally derived tissues.
  38. doi Modeling and experimental assessment of a buried Leu-Ile mutation in dengue envelope domain III
    Manjiri R Kulkarni
    Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2 24 16, Nakamachi, Koganei Shi, Tokyo, 184 8588, Japan
    Biochem Biophys Res Commun 471:163-8. 2016
    Envelope protein domain III (ED3) of the dengue virus is important for both antibody binding and host cell interaction...
  39. doi Association between the CpG island methylator phenotype and its prognostic significance in primary pulmonary adenocarcinoma
    Young Wha Koh
    Department of Pathology, Ajou University School of Medicine, Suwon, South Korea
    Tumour Biol 37:10675-84. 2016
    ..adenocarcinoma after a surgical resection, we performed methylation analysis of six genes (CCNA1, ACAN, GFRA1, EDARADD, MGC45800, and p16 (INK4A)) in 230 pulmonary adenocarcinoma cases using the SEQUENOM MassARRAY platform...
  40. pmc Hemocyanin from Shrimp Litopenaeus vannamei Has Antiproliferative Effect against HeLa Cell In Vitro
    Liyuan Zheng
    Department of Biology and Guangdong Provincial Key laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China
    PLoS ONE 11:e0151801. 2016
    ..1/2 (G3PDH1/2), aldosereductase, ectodemal dysplasia receptor associated death receptor domain isoform CRA_a (EDARADD), heat shock 60kD protein 1 variant 1 (HSP60), heat shock 70kDa protein 5 precursor (HSP70), heat shock protein ..
  41. doi Mutational spectrum in 101 patients with hypohidrotic ectodermal dysplasia and breakpoint mapping in independent cases of rare genomic rearrangements
    Sigrun Wohlfart
    Department of Pediatrics, German Competence Center for Children with Ectodermal Dysplasias, University Hospital Erlangen, Erlangen, Germany
    J Hum Genet 61:891-897. 2016
    ..If caused by mutations in the genes EDA, EDA1R or EDARADD, phenotypes are often very similar as the result of a common signaling pathway...
  42. pmc Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology
    Ali Azar
    Developmental Biology Division
    Hum Mol Genet 25:3564-3577. 2016
    Hypohidrotic ectodermal dysplasia (HED) results from mutation of the EDA, EDAR or EDARADD genes and is characterized by reduced or absent eccrine sweat glands, hair follicles and teeth, and defective formation of salivary, mammary and ..
  43. pmc Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients
    Binghui Zeng
    Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat Sen University, Guangzhou 510055, China
    Genes (Basel) 7:. 2016
    ..Ectodysplasin A (EDA), Ectodysplasin A receptor (EDAR), and EDAR-associated death domain (EDARADD) are candidate genes for HED, but the relationship between WNT10A and HED has not yet been validated...
  44. pmc Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis
    Alessandro Salvi
    Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, I 25123 Brescia, Italy
    Int J Mol Med 38:1338-1348. 2016
    ..individuals were siblings and also carried a heterozygous functional variant in EDAR-associated death domain (EDARADD) (rs114632254), another disease causing gene, generating a combination of genetic variants never described until ..
  45. doi [Clinical and molecular study in a family with autosomal dominant hypohidrotic ectodermal dysplasia]
    Michele Callea
    Unit of Dentistry, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
    Arch Argent Pediatr 116:e34-e38. 2017
    ..in development of structure derived from the ectoderm and is caused by mutations in the genes EDA, EDAR, or EDARADD. Phenotypes caused by mutations in these three may exhibit similar clinical features, explained by a common ..
  46. ncbi Rat bone marrow and monocyte cultures: influence of culture time and lymphokines on the expression of macrophage differentiation antigens
    J G Damoiseaux
    Department of Cell Biology, Medical Faculty, Vrije Universiteit, Amsterdam, The Netherlands
    J Leukoc Biol 46:246-53. 1989
    ..The expression of the ED3 antigen is highly inducible in bone marrow cultures...
  47. ncbi Molecular epidemiology of HIV-1 in Venezuela: high prevalence of HIV-1 subtype B and identification of a B/F recombinant infection
    Erika Castro
    Department of Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 32:338-44. 2003
    ..The discrimination capacity of HIV-1 subtypes using the primer set ED3/14-ED31/33 among the Caracas samples was found to be higher than for those from Margarita Island...
  48. ncbi The distribution of antigen in lymphoid tissues following its injection into the anterior chamber of the rat eye
    Serge Camelo
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Perth, Australia
    J Immunol 172:5388-95. 2004
    ..In the spleen, Ag-bearing cells were CD1(+), CD11b(+), ED1(+), ED2(low), ED3(+), CD86(low), OX6(+), CD11c(-), ED5(-) and in the LNs were CD4(+), CD8(+), CD80(+), and OX41(+) suggesting these ..
  49. ncbi Novel mutations in the EDAR gene in two Pakistani consanguineous families with autosomal recessive hypohidrotic ectodermal dysplasia
    M Naeem
    Department of Biological Sciences, Quaid i Azam University, Islamabad 45320, Pakistan
    Br J Dermatol 153:46-50. 2005
    ..There are X-linked, autosomal recessive and autosomal dominant forms of this disorder. Mutations in the EDA gene cause X-linked HED and mutations in either the EDAR or the EDARADD genes cause autosomal forms of HED.
  50. doi Reasonable design of antibody mimetics for targeting glioma and small cell lung cancer
    Tao Jiang
    Department of Thoracic Surgery, Xi an Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Eur J Cancer Prev 18:431-5. 2009
    ..fused, the mimetic with the first 388 amino acid residues of diphtheria toxin, Escherichia coli strain, BL21 (ED3), was used for expression of soluble immunotoxins DT-BT and DT-TB...
  51. doi A founder ectodysplasin A receptor (EDAR) mutation results in a high frequency of the autosomal recessive form of hypohidrotic ectodermal dysplasia in India
    M D Bashyam
    Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500001, India
    Br J Dermatol 166:819-29. 2012
    ..A receptor (EDAR), encoding the EDA-A1 receptor and ectodysplasin A receptor-associated death domain (EDARADD), encoding an adaptor protein...
  52. pmc Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes
    Trevor J Pitcher
    Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
    Virology 422:386-92. 2012
    The envelope (E) protein is composed of three domains (ED1, ED2 and ED3) with ED3 targeted by the most potent neutralizing antibodies. DENV-2 strains can be divided into six genotypes...
  53. doi Mutations in WNT10A are present in more than half of isolated hypodontia cases
    Marie José van den Boogaard
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Med Genet 49:327-31. 2012
    ..Mutations in MSX1, PAX9, AXIN2 and the ectodermal dysplasia genes EDA, EDAR and EDARADD have been detected in familial severe tooth agenesis...
  54. doi Functional studies for the TRAF6 mutation associated with hypohidrotic ectodermal dysplasia
    H Fujikawa
    Laboratory of Genetic Skin Diseases Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Br J Dermatol 168:629-33. 2013
    ..A de novo heterozygous mutation in the tumour necrosis factor receptor-associated factor 6 gene (TRAF6) was recently identified in a patient with HED, while functional consequences resulting from the mutation remained unknown...
  55. pmc Multiple linear epitopes (B-cell, CTL and Th) of JEV expressed in recombinant MVA as multiple epitope vaccine induces a protective immune response
    Fengjuan Wang
    Key Laboratory of Animal Diseases Diagnosis and Immunology, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China
    Virol J 9:204. 2012
    ..were almost no difference of cytokines and neutralizing antibody titers among 107 TCID50 rMVA-mep, recombinant ED3 and inactivated JEV vaccine...
  56. doi Phenotypic characterization of mononuclear inflammatory cells following equine hydroxyapatite/collagen block grafting in rats
    Asim Alsuwaiyan
    King Fahd Military Medical Complex, Dhahran, Saudi Arabia
    Biomed Mater 7:065005. 2012
    ..monocytic cells (ED1), resident mononuclear phagocytes (ED2), mononuclear phagocytes of lymphoid origin (ED3), expression of Ia antigen (OX6), T-cells (OX19), and B-cells (OX33)...
  57. doi High resolution crystal structure of dengue-3 envelope protein domain III suggests possible molecular mechanisms for serospecific antibody recognition
    Montasir Elahi
    Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei Shi, Tokyo, Japan
    Proteins 81:1090-5. 2013
    ..Here, we report a 1.7 Å crystal structure of a recombinant dengue-3 envelope protein domain III (ED3), which contains most of the putative epitopes...
  58. doi Thermodynamic stability of domain III from the envelope protein of flaviviruses and its improvement by molecular design
    Nora Zidane
    Unit of Molecular Prevention and Therapy of Human Diseases, Department of Infection and Epidemiology, Institut Pasteur, rue du Dr Roux, F 75015 Paris, France
    Protein Eng Des Sel 26:389-99. 2013
    ..Domain III (ED3) of the viral envelope protein interacts with cell receptors and contains epitopes recognized by virus neutralizing ..
  59. doi Ectodysplasin/NF-κB signaling in embryonic mammary gland development
    Päivi H Lindfors
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P O Box 56, 00014, Helsinki, Finland
    J Mammary Gland Biol Neoplasia 18:165-9. 2013
    ..Eda) signaling pathway consists of a TNF-like ligand Eda, its receptor Edar, and an adaptor protein Edaradd and its activation leads to NF-κB mediated transcription...
  60. pmc Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins
    Nora Zidane
    Unit of Molecular Prevention and Therapy of Human Diseases, Department of Infection and Epidemiology, Institut Pasteur, rue du Docteur Roux, F 75015 Paris, France
    BMC Infect Dis 13:302. 2013
    ..Subsequent infection by a different serotype is a risk factor for severe dengue. Domain III (ED3) of the viral envelope protein interacts with cell receptors and contains epitopes recognized by neutralizing ..
  61. pmc Candidate gene analysis of tooth agenesis identifies novel mutations in six genes and suggests significant role for WNT and EDA signaling and allele combinations
    Sirpa Arte
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    PLoS ONE 8:e73705. 2013
    ..Together with our previous reports, we have identified two mutations in MSX1, AXIN2 and EDARADD, five in PAX9, four in EDA and EDAR, and nine in WNT10A...
  62. pmc Involvement of and interaction between WNT10A and EDA mutations in tooth agenesis cases in the Chinese population
    Huiying He
    Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China
    PLoS ONE 8:e80393. 2013
    ..Additionally, EDA, EDAR, and EDARADD encode signaling molecules in the Eda/Edar/NF-κB signaling pathways, we also checked EDAR and EDARADD in this ..
  63. ncbi Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti-rat macrophage antibodies against a heterodimer of 160 and 95 kd (CD11/CD18)
    J G Damoiseaux
    Department of Cell Biology Medical Faculty, Vrije Universiteit, Amsterdam, The Netherlands
    J Leukoc Biol 46:556-64. 1989
    A set of three monoclonal antibodies (MoAbs), ED1, ED2, and ED3, has been shown to recognize in situ different subsets of macrophages in the rat...
  64. ncbi [Pulmonary macrophages in rats after hemithoracic irradiation: analysis of morphology and expression of surface antigen]
    K Soejima
    Department of Radiology, Yamaguchi University School of Medicine, Ube, Japan
    Nihon Kyobu Shikkan Gakkai Zasshi 31:942-50. 1993
    ..monoclonal antibodies to MHC class I (HAM2), MHC class II (OX6) and macrophage differentiation antigens (ED1, ED2, ED3)...
  65. ncbi Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound
    B Sich
    Institut für Biochemie und Endokrinologie, Justus Liebig Universitat Giessen, Germany
    Hypertension 27:1073-8. 1996
    ..a propanol/isopropanol gradient resulted in the separation of three peaks of increasing hydrophobicity (ED1, ED2, ED3) that inhibited the sodium pump of human red blood cells and cross-reacted with proscillaridin A antibodies...
  66. pmc Role of nitric oxide in experimental obliterative bronchiolitis (chronic rejection) in the rat
    E A Kallio
    Cardiopulmonary Research Group of Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Clin Invest 100:2984-94. 1997
    ..of the nitric oxide pathway affected the number of graft-infiltrating CD4+ and CD8+ T cells, ED1+ and ED3+ macrophages, immune activation with expression of IL-2R or MHC class II, or production of macrophage or Th1 ..
  67. ncbi Phenotypic characterization of mononuclear inflammatory cells in salivary glands of bio-breeding rats
    R E Cohen
    Department of Periodontology, School of Dental Medicine, University at Buffalo, NY 14214, USA
    Arch Oral Biol 42:649-55. 1997
    ..membrane antigens associated primarily with monocytes (ED1), mature tissue macrophages (ED2), lymphoid macrophages (ED3), MHC class II (Ia) antigen (OX6), CD5+ T lymphocytes (OX19), and rat B lymphocytes (OX33)...
  68. ncbi Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats
    J V Forrester
    Department of Ophthalmology, University of Aberdeen, Scotland
    Curr Eye Res 17:426-37. 1998
    ..Immunohistochemical studies have previously documented the lymphocyte profiles during various stages of the disease process. The purpose of the present study was to investigate the role of macrophages in EAU...
  69. pmc Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiation program
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    Anat Embryol (Berl) 197:421-37. 1998
    ..We further show that, during earlier stages of embryogenesis (ED3 through ED7), cells expressing smooth muscle proteins appear only in the peri-endothelial region of the aortic and ..
  70. ncbi Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia
    A W Monreal
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Nat Genet 22:366-9. 1999
    ..Dominant disorders, possibly allelic to the recessive loci, are seen in both species (ED3, Dlslk)...
  71. ncbi Blockade of complement inhibits obliterative bronchiolitis in rat tracheal allografts
    E A Kallio
    Cardiopulmonary Research Group of the Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Am J Respir Crit Care Med 161:1332-9. 2000
    ..treatment did not affect the number of graft-infiltrating CD4(+) and CD8(+) T cells, CD45(+) B cells, ED1(+) and ED3(+) macrophages, or immune activation with expression of IL-2Ralpha or MHC class II...
  72. ncbi In vitro characterization of Mato's FGP cells isolated from rat cerebrum
    Tomoko Nakazawa
    Department of Anatomy and Developmental Biology, Medical School, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurosci Lett 317:127-30. 2002
    ..immunoreactions of cultured cells to ED1 and ED2 antibodies were observed, whereas they were weak or negative to ED3 and OX42 antibodies. Acid phosphatase activity was detected in the granules of cultured cells...
  73. ncbi Gene defect in ectodermal dysplasia implicates a death domain adapter in development
    D J Headon
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Nature 414:913-6. 2001
    ..This adapter, which we have called Edaradd (for Edar-associated death domain), interacts with the death domain of Edar and links the receptor to downstream ..
  74. ncbi Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice
    Minhong Yan
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Curr Biol 12:409-13. 2002
    ..This is an unprecedented example of naturally occurring mutations in ligand, receptor, or adaptor giving rise to the same phenotypic disease characterized by a defect in the proper development of epidermal appendages...
  75. ncbi Death receptor signaling giving life to ectodermal organs
    Irma Thesleff
    Developmental Biology Program, Insitute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, 00014 Helsinki, Finland
    Sci STKE 2002:pe22. 2002
    ..also known as EDA), its death domain-containing receptor EDAR, and the death domain adapter molecule EDARADD. This pathway was discovered and delineated through the cloning of genes that cause human hypohidrotic ectodermal ..
  76. ncbi Mesh implants in hernia repair. Inflammatory cell response in a rat model
    R Rosch
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Eur Surg Res 35:161-6. 2003
    ..To approach biocompatibility of surgical meshes we therefore examined the infiltrate of these cells as well as the proliferation rate in response to different clinically applied materials...
  77. ncbi Traf6 is essential for murine tooth cusp morphogenesis
    Atsushi Ohazama
    Department of Craniofacial Development, GKT Dental Institute, King s College, Guy s Hospital, London Bridge, London, United Kingdom
    Dev Dyn 229:131-5. 2004
    ..e., ectodysplasin (EDA), EDA receptor (EDAR), and EDAR-associated death domain (EDARADD; the intracellular adaptor for EDAR), are responsible for several forms of HED in humans and mice...
  78. pmc Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency
    Kim Newton
    Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:1608-13. 2004
    ..an important role in sweat gland, hair, and tooth development; mutations in EDA, EDAR, or the downstream adaptor EDARADD cause hypohidrotic ectodermal dysplasia...
  79. ncbi Developmental changes of keratin expression in chick embryo olfactory epithelium in relation to cellular differentiation and neurogenesis in vivo and in vitro
    Isabelle Comte
    UMR CNRS 6101, Faculte de Medecine, 2 rue du Dr Marcland, 87025 Limoges, Cedex, France
    Brain Res Dev Brain Res 148:1-10. 2004
    ..Olfactory placodes form at embryonic day 3 (ED3) in the anterior facial ectoderm and invaginate to form the nasal pits...
  80. ncbi The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development
    A S Tucker
    Craniofacial Development, Dental Institute, Guy s Hospital, King s College London, London SE1 9RT, UK
    Dev Biol 268:185-94. 2004
    Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps...
  81. ncbi Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys
    Yuichi Kikuchi
    Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    Nephron Exp Nephrol 97:e17-25. 2004
    ..We examined whether fractalkine and CX3CR1 upregulation are found in streptozotocin-induced diabetic kidneys...
  82. ncbi A rare case of hypohidrotic ectodermal dysplasia caused by compound heterozygous mutations in the EDAR gene
    Yutaka Shimomura
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Invest Dermatol 123:649-55. 2004
    ..caused by mutations in the EDA gene, and the autosomal forms result from mutations in either the EDAR gene or the EDARADD gene...
  83. ncbi Limited capability of regional lymph nodes to eradicate metastatic cancer cells
    Hiroshi Nagata
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Cancer Res 64:8239-48. 2004
    ..Germinal centers and lymphoid cells in the medulla proliferated before 48 hours. ED3(+) macrophages incorporated apoptotic cancer cells, but significant cancer proliferation occurred after 4 days...
  84. ncbi Tissue response to partially in vitro predegraded poly-L-lactide implants
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 26:1781-91. 2005
    ..In the capsule macrophage like cells expressed all three macrophage markers ED1, ED2, and ED3. CD4 and CD8 positive cells, indicating T helper and T supressor/cytotoxic cells, respectively, could be observed ..
  85. ncbi Energy density of diets reported by American adults: association with food group intake, nutrient intake, and body weight
    A K Kant
    Department of Family, Nutrition, and Exercise Sciences, Queens College of the City University of New York, Flushing, NY 11367, USA
    Int J Obes (Lond) 29:950-6. 2005
    ..However, little is known about the energy density of diets consumed by free-living populations; therefore, the purpose of this study was to examine demographic, health, and nutritional correlates of energy density of self-reported diets...
  86. ncbi Intercellular growth factor signaling and the development of mouse tracheal submucosal glands
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Dyn 233:1378-85. 2005
    ..Glands are completely absent in mice lacking Ectodysplasin (Eda) and Edaradd (Eda receptor adaptor protein), members of the tumor necrosis (TNF) superfamily of signaling factors...
  87. ncbi TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd
    Aurore Morlon
    Unité de Recherche sur les Handicaps Génétiques de l Enfant INSERM U 393, Hopital Necker Enfants Malades, 149 rue de Sévres 75015 Paris, France
    Hum Mol Genet 14:3751-7. 2005
    Activation of the NF-kappaB pathway by the TNF-receptor Edar (Ectodysplasin receptor) and its downstream adaptator Edaradd (Edar-associated death domain) is essential for the development of hair follicles, teeth, exocrine glands and ..
  88. ncbi Mutations in EDAR account for one-quarter of non-ED1-related hypohidrotic ectodermal dysplasia
    N Chassaing
    Service de Genetique Medicale, Hopital Purpan, Toulouse, France
    Hum Mutat 27:255-9. 2006
    ..and -recessive forms occur occasionally and result from mutations in at least two genes: EDAR and EDARADD. These different forms are phenotypically indistinguishable...
  89. ncbi [Prokaryotic expression and identification of human papillomavirus type 16 E5 protein]
    Qiao fa Shi
    Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:31-5. 2006
    ..To construct the prokaryotic and eukaryotic expression vectors pET32/E5 and pcDNA3.1/E5 for transformation into E. coli BL21 and NIH(3)T(3) cells respectively to observe the expression of human papillomavirus type 16 E5 protein (HPV16 E5)...
  90. pmc EDA signaling and skin appendage development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 5:2477-83. 2006
    ..EDA signaling is mediated by ectodysplasin, EDAR and EDARADD, which form a new TNF ligand-receptor-adaptor family that is restricted to skin appendages in vertebrates from ..
  91. pmc Solution structure of the envelope protein domain III of dengue-4 virus
    David E Volk
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1157, USA
    Virology 364:147-54. 2007
    ..Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3), the receptor-binding domain, of the envelope protein of DEN4 virus, human strain 703-4...
  92. ncbi Bacterial growth yields on EDTA, NTA, and their biodegradation intermediates
    Zhiwen Yuan
    Department of Civil, Environmental, and Architectural Engineering, University of Colorado at Boulder, Engineering Center ECOT 441, UCB 428, Boulder, CO 80309, USA
    Biodegradation 19:41-52. 2008
    ..0 g of cell dry weight (CDW) (mole of EDTA)(-1), 68.6 g of CDW (mole of ED3 A)(-1), 51.2 g of CDW (mole of N,N'-EDDA)(-1), 34.5 g of CDW (mole of ED)(-1), 26.3 g of CDW (mole of IDA)(-1), 12...
  93. ncbi Hypocellularity and absence of compaction as criteria for embryonic death
    Donald W Landry
    Division of Experimental Therapeutics, Columbia University, New York, NY 10032, USA
    Regen Med 1:367-71. 2006
    ..For developed humans, life is considered to end when the criteria for brain death are met, but corresponding criteria are lacking for human embryos, and thus, we undertook a natural history study of embryonic death...
  94. ncbi A novel 4-bp insertion mutation in EDA1 gene in a Pakistani family with X-linked hypohidrotic ectodermal dysplasia
    Muhammad Tariq
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Eur J Dermatol 17:209-12. 2007
    ..Mutations in the EDA 1 gene cause X-linked HED and mutations in either EDAR or EDARADD genes cause autosomal forms of HED...
  95. ncbi Establishment of immortalized rat Kupffer cell lines
    Yanhua Peng
    James A Haley Veterans Affairs Medical Center, Department of Surgery, University of South Florida Health Sciences Center, C O Tampa General Hospital, Tampa, FL 33601, USA
    Cytokine 37:185-91. 2007
    ..Primary cultures of Kupffer cells have a very limited life span, tend to de-differentiate and become senescent, and therefore are not suitable for cell signaling studies...
  96. ncbi Mapping to completeness and transplantation of a group-specific, discontinuous, neutralizing epitope in the envelope protein of dengue virus
    Olesia Lisova
    Unit of Molecular Prevention and Therapy of Human Diseases CNRS URA3012, Institut Pasteur, 28 rue Docteur Roux, F 75724 Paris Cedex 15, France
    J Gen Virol 88:2387-97. 2007
    ..of antibody mAb4E11, which neutralizes the four serotypes of DENV but no other flavivirus, and binds domain 3 (ED3) of their envelope glycoprotein, was characterized...
  97. ncbi Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virus
    Gregory D Gromowski
    Department of Pathology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Virology 366:349-60. 2007
    ..The E protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3, of which ED3 contains the critical and dominant virus-specific neutralization sites...
  98. ncbi Long range communication in the envelope protein domain III and its effect on the resistance of West Nile virus to antibody-mediated neutralization
    Rodrigo A Maillard
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1055, USA
    J Biol Chem 283:613-22. 2008
    The envelope protein domain III (ED3) of West Nile virus is the major virus-specific neutralization domain and harbors most of the critical mutations that induce resistance against antibody-mediated neutralization...
  99. pmc Is the hair follicle necessary for normal wound healing?
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 128:1059-61. 2008
    ..To address this question, Langton et al. (this issue, 2008) take advantage of the Edaradd mutant mouse, which lacks hair follicles on its tail...
  100. pmc The surface-exposed carboxyl region of Mycoplasma pneumoniae elongation factor Tu interacts with fibronectin
    Sowmya Balasubramanian
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Infect Immun 76:3116-23. 2008
    ..Further analysis of carboxyl constructs (ED3 and ED4) and their deletion truncations (ED3.1, ED3.2, and ED4...

Research Grants7

  1. Antiviral Agents directed at West Nile Virus
    STEVEN WHITTEN; Fiscal Year: 2004
    ..Binding and structural studies will be carried out against the West Nile envelope protein Domain III (WN-ED3)...
  2. BIOENERGETICS OF EXERCISE-INDUCED MENSTRUAL DISTURBANCES
    Nancy Williams; Fiscal Year: 2003
    ..The results will also expand our understanding of the mechanism of the modulation of reproductive function by energy availability. ..
  3. Relation of diet quality with mortality
    ASHIMA KANT; Fiscal Year: 2002
    ..abstract_text> ..
  4. Dietary pattern indexes: relation with CVD risk factors
    ASHIMA KANT; Fiscal Year: 2003
    ..We will use dietary, anthropometric, biochemical, and health data from the third National Health and Nutrition Examination Survey, 1988-1994 (>15,000), to address these issues. ..
  5. Trends in socioeconomic position and diet relationship
    ASHIMA KANT; Fiscal Year: 2005
    ..The proposed study will thus contribute to progress towards the stated goals of Healthy People 2010 and the National Cancer Institute. ..
  6. Trends in food consumption patterns of Americans
    ASHIMA KANT; Fiscal Year: 2005
    ..abstract_text> ..
  7. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2008
    ..The proposed investigation will contribute to a better understanding of satellite cell dynamics and muscle growth, and can prove important for muscle rehabilitation strategies during disease and aging. ..