EBI3

Summary

Gene Symbol: EBI3
Description: Epstein-Barr virus induced 3
Alias: IL-27B, IL27B, IL35B, interleukin-27 subunit beta, EBV-induced gene 3 protein, Epstein-Barr virus induced gene 3, IL-27 subunit beta, IL27 subunit, IL35 subunit, cytokine receptor, epstein-Barr virus-induced gene 3 protein
Species: human

Top Publications

  1. pmc A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    O Devergne
    Department of Microbiology and Molecular Genetics, Harvard University, Boston, Massachusetts, USA
    J Virol 70:1143-53. 1996
  2. pmc Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    O Devergne
    Department of Medicine, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:12041-6. 1997
  3. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
  4. doi Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor
    Marco A Poleganov
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, 60590 Frankfurt am Main, Germany
    Mol Immunol 45:2869-80. 2008
  5. ncbi Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease
    Thomas Gehlert
    Institute for Pathology, Friedrich Alexander University, Erlangen, Germany
    J Med Virol 73:432-8. 2004
  6. ncbi Hepatocyte growth factor/scatter factor in the eye
    I Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, Duncan Building, L69 3GA, Liverpool, UK
    Prog Retin Eye Res 19:779-802. 2000
  7. ncbi Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence
    A Mandal
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4949, USA
    J Biol Chem 272:20306-11. 1997
  8. ncbi Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand
    R E Pacifici
    Department of Molecular Biology, Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    J Biol Chem 269:1571-4. 1994
  9. ncbi Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis
    Piotr Rutkowski
    Department of Soft Tissue Bone Sarcomas, M Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    J Surg Oncol 84:151-9. 2003
  10. ncbi Cytokine receptor signal transduction mechanisms in immuno-hematopoietic cells
    V Chiarugi
    Laboratory of Molecular Biology, University of Florence
    Tumori 79:92-9. 1993

Research Grants

  1. TIMOTHY L MANSER; Fiscal Year: 2014
  2. Margot S Damaser; Fiscal Year: 2014
  3. Growth Hormone Regulation of SH2-B1
    Christin Carter Su; Fiscal Year: 2009
  4. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
  5. Effect of a viral replicon adjuvant on dendritic cell activity
    DANIEL TONKIN; Fiscal Year: 2010
  6. T Cell Homeostasis in Systemic Autoimmunity
    Argyrios N Theofilopoulos; Fiscal Year: 2012
  7. Chronic Pain and Emotional Learning and Memory
    APKAR VANIA APKARIAN; Fiscal Year: 2012
  8. David M Underhill; Fiscal Year: 2016
  9. Laurence A Turka; Fiscal Year: 2014
  10. Stefanie N Vogel; Fiscal Year: 2014

Detail Information

Publications297 found, 100 shown here

  1. pmc A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    O Devergne
    Department of Microbiology and Molecular Genetics, Harvard University, Boston, Massachusetts, USA
    J Virol 70:1143-53. 1996
    ..EBI3 maps to chromosome 19p13.2/3, near genes encoding the erythropoietin receptor and the cytokine receptor-associated kinase, Tyk2...
  2. pmc Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    O Devergne
    Department of Medicine, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:12041-6. 1997
    The Epstein-Barr virus-induced gene 3 (EBI3) is a novel soluble hematopoietin component related to the p40 subunit of interleukin 12 (IL-12)...
  3. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
    ..It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.
  4. doi Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor
    Marco A Poleganov
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, 60590 Frankfurt am Main, Germany
    Mol Immunol 45:2869-80. 2008
    ..Besides the chemokines CXCL10, CXCL11, and CCL1 we identified Epstein-Barr virus induced gene-3 (EBI3)/IL-27B as being among those genes that are profoundly upregulated by IL-18 in KG1 cells...
  5. ncbi Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease
    Thomas Gehlert
    Institute for Pathology, Friedrich Alexander University, Erlangen, Germany
    J Med Virol 73:432-8. 2004
    ..Interestingly, expression levels of the EBV-induced gene 3 (EBI3), a molecule belonging to the interleukin (IL)-12 family, have also been reported to be elevated in ulcerative ..
  6. ncbi Hepatocyte growth factor/scatter factor in the eye
    I Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, Duncan Building, L69 3GA, Liverpool, UK
    Prog Retin Eye Res 19:779-802. 2000
    ..Finally HGF/SF may be involved in the metastatic spread of tumour cells from uveal melanomata and in the formation of vascular channels in these tumours...
  7. ncbi Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence
    A Mandal
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4949, USA
    J Biol Chem 272:20306-11. 1997
    ..This signaling mechanism implicates cytokine receptor-induced ether-linked diglycerides as second messengers that inhibit the bioactivity of calcium-insensitive ..
  8. ncbi Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand
    R E Pacifici
    Department of Molecular Biology, Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    J Biol Chem 269:1571-4. 1994
    ..mitogenic signal transduction, much less is known about such mechanisms for members of the hematopoietic cytokine receptor family...
  9. ncbi Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis
    Piotr Rutkowski
    Department of Soft Tissue Bone Sarcomas, M Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    J Surg Oncol 84:151-9. 2003
    ....
  10. ncbi Cytokine receptor signal transduction mechanisms in immuno-hematopoietic cells
    V Chiarugi
    Laboratory of Molecular Biology, University of Florence
    Tumori 79:92-9. 1993
    Novel aspects of cytokine receptor signal transduction are discussed and cytokine receptors classified based on ligand-dependent signalling. An introductory section presents an overview of the role of cytokines in hematopoiesis...
  11. ncbi Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth
    I Vigon
    INSERM U363, ICGM, Hopital Cochin, Paris, France
    Oncogene 8:2607-15. 1993
    ..leukemia virus (MPLV) encodes a truncated form of a putative receptor protein that belongs to the cytokine receptor superfamily. We previously reported the cloning of complete human c-MPL cDNA...
  12. ncbi MAPPIT: a cytokine receptor-based two-hybrid method in mammalian cells
    J Tavernier
    VIB09 Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Department of Biochemistry, Ghent University, Ghent Belgium
    Clin Exp Allergy 32:1397-404. 2002
    ....
  13. ncbi The murine interleukin-3 receptor alpha subunit gene: chromosomal localization, genomic structure, and promoter function
    I Miyajima
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto
    Blood 85:1246-53. 1995
    The interleukin-3 receptor (IL-3R) is composed of alpha and beta subunits, members of the class I cytokine receptor family...
  14. pmc Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population
    N Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Tissue Antigens 72:211-20. 2008
    We genotyped a Somali population (n = 85; age < or =30 years) for 617 cytokine and cytokine receptor single nucleotide polymorphisms (SNPs) using Illumina GoldenGate genotyping to determine associations with measles, mumps and rubella ..
  15. ncbi A role for leptin and its cognate receptor in hematopoiesis
    B D Bennett
    Department of Molecular Oncology, Genentech Inc, 460 Point San Bruno Blvd, South San Francisco, California 94080, USA
    Curr Biol 6:1170-80. 1996
    ..In this study, we have undertaken a search for novel cytokines that may influence the fate of hematopoietic stem cells...
  16. doi Tocilizumab: an interleukin-6 receptor inhibitor for the treatment of rheumatoid arthritis
    Susyn L Plushner
    Clinical Pharmacy Specialist in Rheumatology and Therapeutic Initiatives, 2045 Franklin St, Denver, CO 80205, USA
    Ann Pharmacother 42:1660-8. 2008
    To review the pharmacology, pharmacokinetics, clinical trial data, and safety profile of tocilizumab, a new biologic agent targeting the interleukin-6 cytokine receptor.
  17. ncbi Preclinical results of sirolimus treatment in transplant models
    S M Stepkowski
    Division of Immunology and Organ Transplantation, Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Transplant Proc 35:219S-226S. 2003
    ..Signal 3 (cytokine/cytokine receptor) initiate cell division and differentiation in the late G(1)/S phase...
  18. ncbi Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes
    Irma Airoldi
    Laboratories of Oncology and Pathology, G Gaslini Institute, Genoa, Italy, and Laboratory of Pathology, St Andrea Hospital, La Spezia, Italy
    Clin Cancer Res 10:144-54. 2004
    Dysregulated cytokine/cytokine receptor expression may occur in B-cell lymphoproliferative disorders. Little information is available on interleukin-18 receptor (IL-18R) and IL-18 expression in normal and malignant B cells...
  19. ncbi Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    J Biol Chem 273:15719-26. 1998
    Growth hormone (GH) and prolactin (PRL) binding to their receptors, which belong to the cytokine receptor superfamily, activate Janus kinase (JAK) 2 tyrosine kinase, thereby leading to their biological actions...
  20. ncbi Determinants of growth hormone receptor down-regulation
    Luqin Deng
    Department of Cell Biology, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 21:1537-51. 2007
    GH receptor (GHR) is a cytokine receptor family member that responds to GH by activation of the receptor-associated tyrosine kinase, JAK2 (Janus family of tyrosine kinase 2)...
  21. ncbi Signal transduction for interleukin-3-dependent leukotriene synthesis in normal human basophils: opposing role of tyrosine kinase and protein kinase
    M Krieger
    Institute of Clinical Immunology, Inselspital, Bern, Switzerland
    Eur J Immunol 22:2907-13. 1992
    ..In addition, the signal transduction mechanisms utilized by the cytokine receptor family are still poorly understood...
  22. ncbi Endogenous ciliary neurotrophic factor protects GABAergic, but not cholinergic, septohippocampal neurons following fimbria-fornix transection
    Thomas Naumann
    Institute of Anatomy, University of Freiburg, Germany
    Brain Pathol 13:309-21. 2003
    ..In addition, we studied the cellular expression of CNTF, LIF and related cytokine receptor components in the septal complex following lesion...
  23. pmc Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding
    F C Stomski
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Mol Cell Biol 16:3035-46. 1996
    ..These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a ..
  24. ncbi TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3
    S E Jacobsen
    Laboratory of Leukocyte Biology, National Cancer Institute, Bethesda, MD 20892
    J Immunol 151:4534-44. 1993
    ..Therefore, the ability of TGF-beta to modulate the CSF receptor density/cell and/or the actual number of progenitors expressing CSF receptors directly correlates with the multifunctional effects of TGF-beta in hematopoiesis...
  25. pmc Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    Xiaohui Lu
    Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:18962-7. 2005
    ..Here, we show that coexpression of the JAK2V617F mutant kinase with a homodimeric Type I cytokine receptor, the erythropoietin receptor (EpoR), the thrombopoietin receptor, or the granulocyte colony-stimulating-..
  26. pmc Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
    K Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Proc Natl Acad Sci U S A 97:11439-44. 2000
    We have identified a type I cytokine receptor, which we have termed novel interleukin receptor (NILR), that is most related to the IL-2 receptor beta chain (IL-2Rbeta) and physically adjacent to the IL-4 receptor alpha chain gene on ..
  27. pmc Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes
    N Dagoneau
    Department of Genetics and INSERM U781, Universite Paris Descartes, Paris, France
    Am J Hum Genet 80:966-70. 2007
    ..factor receptor gene in Crisponi syndrome and the identification of homozygote or compound heterozygote cytokine receptor-like factor 1 (CRLF1) mutations in four children from three unrelated families...
  28. pmc Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pediatrics 121:e1091-9. 2008
    ..We set out to assess whether HLA and cytokine gene polymorphisms are associated with variations in the immune response to mumps viral vaccine...
  29. pmc A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
    D H Presky
    Department of Inflammation Autoimmune Diseases, Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
    Proc Natl Acad Sci U S A 93:14002-7. 1996
    ..This newly identified huIL-12R subunit is a member of the cytokine receptor superfamily, with closest resemblance to the beta-type cytokine receptor gp130 and the receptors for ..
  30. ncbi Effects of in vivo exposure to bis(tri-n-butyltin)oxide, hexachlorobenzene, and benzo(a)pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels
    R J Vandebriel
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 148:126-36. 1998
    ....
  31. ncbi In vivo expression of cytokine receptor mRNA in atopic dermatitis
    R A Taha
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 102:245-50. 1998
    ..Chronic lesions are rich in eosinophils and monocyte/macrophages and contain a greater number of IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-12 (p40) mRNA-positive cells...
  32. ncbi Th17 T cells: linking innate and adaptive immunity
    Brigitta Stockinger
    Division of Molecular Immunology, The MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Semin Immunol 19:353-61. 2007
    ..Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995;3(6):811-21; Kennedy J, Rossi DL, Zurawski SM, Vega Jr F, Kastelein RA, Wagner JL, et al...
  33. ncbi Cytokines, acute-phase proteins, and hormones: IL-1 and TNF-alpha production in contact-mediated activation of monocytes by T lymphocytes
    Danielle Burger
    Division of Immunology and Allergy Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, CH 1211 Geneva 14, Switzerland
    Ann N Y Acad Sci 966:464-73. 2002
    ..taking into account the levels of other synergistic cytokines, of their respective inhibitors, and of each cytokine receptor. Due to their potent activities in many different processes (including cell growth and differentiation, ..
  34. ncbi Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice
    Jian Zhong
    Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky Medical Center, MN649 0298, Lexington, KY 40536, USA
    Biochim Biophys Acta 1762:468-77. 2006
    ..In addition, pro-inflammatory cytokine receptor mRNA levels (TNF-alpha, TGF-beta, and IL-1 beta) were markedly up-regulated by LPS at all time points in IL-..
  35. pmc SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine
    Neelam Dhiman
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Immunogenetics 62:197-210. 2010
    ..Identification of such "genetic fingerprints" may predict the outcome of vaccine response and inform new vaccine strategies...
  36. ncbi Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit
    Johan Lennartsson
    Basic Research Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 279:44544-53. 2004
    ..SCF also synergizes with a variety of growth factors, including those binding members of the cytokine receptor superfamily. The mechanisms mediating this synergy remain to be defined...
  37. doi Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAK
    Anne Elisabeth Mas
    Unité 782 INSERM, Hôpital Antoine Béclére AP HP 92141 Clamart, France
    Am J Reprod Immunol 59:323-38. 2008
    ..We therefore searched for regulators of the IL-12/IL-18 family of cytokines as well as for antagonist(s) of TNF with potentially selective effects on implantation...
  38. ncbi Expression analysis and characterization of alternatively spliced transcripts of human IL-7Ralpha chain encoding two truncated receptor proteins in relapsed childhood all
    A Korte
    Department of Pediatric Oncology Hematology, Charite Medical Center, Campus Virchow, Germany
    Cytokine 12:1597-608. 2000
    ..The splicing-derived cytokine receptor protein isoforms are mostly soluble receptors or show alterations in their cytoplasmic domain...
  39. doi Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    Takashi Igawa
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Mod Rheumatol 19:33-41. 2009
    ..the role of IL-27 in the development of autoimmune disorders in MRL/lpr mice, we disrupted the EBV-induced gene 3 (EBI3), which is a subunit of IL-27...
  40. ncbi CYRL, a novel cytokine receptor-like protein expressed in testis, lung, and spleen
    S L Chritton
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, 02114, USA
    Biochem Biophys Res Commun 267:697-702. 2000
    ..of a rat brain cDNA transcript with significant homology to IL-3Ralpha, which we have termed CYRL, for CYtokine Receptor-Like protein...
  41. ncbi A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5
    Nico Ghilardi
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:16831-6. 2002
    Here we report the cloning of a novel type I cytokine receptor, gp130-like monocyte receptor (GLM-R), with homology to the interleukin-6 receptor signal transducing chain, gp130, and granulocyte colony-stimulating factor receptor...
  42. ncbi A cytokine receptor gene cluster in the X-Y pseudoautosomal region?
    E Kremer
    Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, Australia
    Blood 82:22-8. 1993
    ..Using long-range restriction mapping we have found that IL3RA maps to the same 190-kb restriction fragment as CSF2RA, suggesting that a cytokine receptor gene cluster may reside in the PAR.
  43. ncbi Comparative study on the expression of cytokine--receptor genes in normal and preeclamptic human placentas using DNA microarrays
    Zhan Jun Pang
    Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou, China
    J Perinat Med 31:153-62. 2003
    ..To study the relationship between the expression levels of cytokine/receptor genes in placenta and the pathogenesis of pre-eclampsia...
  44. doi Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutation
    Masanori Yamazaki
    Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 152:764-9. 2010
    Cold-induced sweating syndrome (CISS) is a rare autosomal recessive disorder caused by mutations in CRLF1 (cytokine receptor-like factor 1), characterized by profuse sweating in cold environmental temperature and craniofacial and ..
  45. ncbi Analysis of interleukin receptor gene expression in mouse fetal liver by quantitative polymerase chain reaction
    G Q Jia
    Center for Blood Research, Inc, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 25:2096-100. 1995
    ..sensitive polymerase chain reaction (PCR)-based method for the quantification of low-abundance RNA for mouse cytokine receptor genes...
  46. ncbi Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR
    Y Tonozuka
    Division of Hematopoietic Factors, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cytogenet Cell Genet 93:23-5. 2001
    In a search for a human sequence related to a recently identified type I cytokine receptor delta1, which turned out to be a receptor subunit for a cytokine called TSLP, we have now identified a novel human type I cytokine receptor from a ..
  47. doi Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells
    Ka Kui Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Pathol 221:164-74. 2010
    ..We also found that BCL10, a key mediator of NF-kappaB signalling, participates in the cytokine receptor-induced activation of NF-kappaB...
  48. ncbi Growth hormone receptor interaction with Jak proteins differs between tissues
    G Hellgren
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Interferon Cytokine Res 21:75-83. 2001
    Janus kinases (Jak) play an important role in the initial steps of cytokine receptor signaling. The specificity of the four members of the Jak family (Jak1, Jak2, Jak3, and Tyk2) for different cytokine receptors is not fully understood...
  49. ncbi NMR backbone dynamics of the human type I interferon binding subunit, a representative cytokine receptor
    Jordan H Chill
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 43:10127-37. 2004
    ..As the first cytokine receptor structure determined in the unliganded state and in solution, IFNAR2-EC offers an opportunity to ..
  50. ncbi RANKL in human periapical granuloma: possible involvement in periapical bone destruction
    R Vernal
    Periodontal Biology Laboratory, Dentistry Faculty, University of Chile, Santiago, Chile
    Oral Dis 12:283-9. 2006
    The cytokine receptor activator of nuclear factor kappaB-ligand (RANKL) has been involved in both the physiological and pathological regulation of osteoclast life span and bone metabolism...
  51. ncbi Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    J Infect Dis 195:21-9. 2007
    ..Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity...
  52. ncbi Structure of mouse interleukin 3 (IL-3) binding protein (AIC2A). Amino acid residues critical for IL-3 binding
    H M Wang
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
    J Biol Chem 267:979-83. 1992
    ..The extracellular domain of the AIC2A protein has two repeats of the common motif shared by members of the cytokine receptor family. Neither one of these repeats alone bound IL-3...
  53. pmc Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 69:2617-20. 1995
    ..Potential candidate genes for Rfv3 are several genes expressed in cells of the immune system and previously mapped to the same region, including a T-cell antigen gene, Ly6, and three cytokine receptor genes, IL2rb, IL3rb1, and IL3rb2.
  54. ncbi Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Nature 370:153-7. 1994
    Many cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation...
  55. ncbi Immunodeficiencies and haematological disorders--direct connections to cellular signalling pathways
    O Silvennoinen
    Institute of Medical Technology, University of Tampere, Department of Clinical Microbiology, Tampere University Hospital, Finland
    Ann Med 29:519-29. 1997
    ..to intracellular signal transduction have revealed a general mechanism for both the antigen receptor and the cytokine receptor nuclear signalling...
  56. pmc Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment
    A C Ward
    Institute of Hematology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 190:497-507. 1999
    ..Together these data add to our understanding of the mechanisms of cytokine receptor signaling, emphasize the role of GCSFR mutations in the etiology of SCN, and implicate such mutations in G-..
  57. ncbi In vitro exposure effects of cyclosporin A and bis(tri-n-butyltin)oxide on lymphocyte proliferation, cytokine (receptor) mRNA expression, and cell surface marker expression in rat thymocytes and splenocytes
    R J Vandebriel
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Toxicology 135:49-66. 1999
    ..Furthermore, the data obtained suggest that antiproliferative effects may be more relevant than apoptosis induction for TBTO induced thymus atrophy...
  58. ncbi Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes
    W Zhang
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Biochem Biophys Res Commun 281:878-83. 2001
    From a human dendritic cell (DC) cDNA library, we identified a novel type I cytokine receptor, designated as cytokine receptor-like molecule 2 (CRL2)...
  59. ncbi Type I interferons and limitin: a comparison of structures, receptors, and functions
    K Oritani
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
    Cytokine Growth Factor Rev 12:337-48. 2001
    ..Their receptors, IFNAR1 and IFNAR2, belong to the class II cytokine receptor family for a-helical cytokines...
  60. ncbi Soluble cytokine receptors in biological therapy
    Rafael Fernandez-Botran
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Expert Opin Biol Ther 2:585-605. 2002
    ..This TNF-alpha; antagonist was the first soluble cytokine receptor to receive approval for use in humans...
  61. pmc Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice
    Wouter J de Jonge
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    J Clin Invest 110:1539-48. 2002
    ..b>Cytokine receptor levels in the bone marrow were normal...
  62. ncbi Sensing infection in Drosophila: Toll and beyond
    Dominique Ferrandon
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15, rue R Descartes, F67084 Strasbourg Cedex, France
    Semin Immunol 16:43-53. 2004
    ..to the mammalian system, the Toll receptor does not act as a pattern recognition receptor (PRR) but as a cytokine receptor. The sensing of microbial infections is achieved by at least four PRRs that belong to two distinct families: ..
  63. ncbi Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice
    Yoshiyuki Miyazaki
    PRESTO, Japan Science and Technology Agency, Saitama, Japan
    J Immunol 175:2401-7. 2005
    WSX-1 (IL-27R) is a class I cytokine receptor with homology to gp130 and IL-12 receptors and is typically expressed on CD4+ T lymphocytes...
  64. ncbi Janus kinase 2 influences growth hormone receptor metalloproteolysis
    Kimberly Loesch
    Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294 0012, USA
    Endocrinology 147:2839-49. 2006
    GH signals through the GH receptor (GHR), a cytokine receptor superfamily member that couples to the cytoplasmic tyrosine kinase, Janus kinase 2 (JAK2)...
  65. ncbi General nature of the STAT3-activated anti-inflammatory response
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude s Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 177:7880-8. 2006
    ..We found that heterologous cytokine receptor systems that activate STAT3 but are naturally refractory (the IL-22R), or engineered to be refractory (the ..
  66. ncbi Expression of IL-12-related molecules in human intestinal microvascular endothelial cells is regulated by TLR3
    Jan Heidemann
    Dept of Medicine B, Univ of Münster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Am J Physiol Gastrointest Liver Physiol 293:G1315-24. 2007
    ..HIMEC display an induction of Epstein-Barr virus-induced gene 3 (EBI3), IL-12p35, and IL-23p19, whereas no expression of IL-12p40 and IL-27p28 was detectable...
  67. pmc Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
    Sherry L Laporte
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 132:259-72. 2008
    ....
  68. doi The role of IL-21 in regulating B-cell function in health and disease
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 223:60-86. 2008
    ..IL-2, IL-4, IL-7, IL-9, and IL-15, all of which bind to private (or shared) receptors as well as the common cytokine receptor gamma-chain as a component...
  69. pmc The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation
    Zheng Wu
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Blood 112:4411-9. 2008
    ..The IL-15 receptor consists of IL-15Ralpha, IL-2Rbeta, and the common cytokine receptor gamma chain (gamma(c))...
  70. doi Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma
    Alfons Navarro
    Human Anatomy Unit, Molecular Oncology and Embryology Laboratory, University of Barcelona Medical School, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Blood 114:2945-51. 2009
    ..a direct regulation by miR-135a of JAK2, a cytoplasmic tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways...
  71. doi Production of human antibodies to native cytokine receptors using the genetic immunization of KM mice
    Akira Fujimoto
    Department of Biological Science and Technology, Tokyo University of Science, Noda shi, Chiba 278 8510, Japan
    Hum Antibodies 18:75-80. 2009
    ..The immunization of KM mice using expression plasmids containing genes encoding three different human cytokine receptor genes, CXCR4, CCR3, and CCR5, resulted in significant Ab responses to these receptors...
  72. doi Characterization of the effects of prolactin in gonadotroph target cells
    David J Hodson
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Biol Reprod 83:1046-55. 2010
    ..studies revealed that the stimulatory effects of PRL on LH release are not mediated by the conventional cytokine receptor pathways but, rather, by a novel JAK2-PIK3-PKC-dependent signaling cascade...
  73. doi Stimulatory effect of LPS and feedback effect of PGE2 on IL-27 production
    C L Zhu
    Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
    Scand J Immunol 72:469-75. 2010
    ..IL)-27 is a new member of the IL-6/IL-12 family, composed of two subunits, the Epstein-Barr virus-induced gene 3 (EBI3) and p28 chains (p28), and produced by activated monocytes and dendritic cells...
  74. pmc Matrix-embedded cells control osteoclast formation
    Jinhu Xiong
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas, USA
    Nat Med 17:1235-41. 2011
    Osteoclasts resorb the mineralized matrices formed by chondrocytes or osteoblasts. The cytokine receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast formation and thought to be supplied by osteoblasts or ..
  75. doi A predicted miR-27a-mediated network identifies a signature of glioma
    Shuxu Yang
    Department of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, PR China
    Oncol Rep 28:1249-56. 2012
    ..signaling pathway, the transforming growth factor-β (TGF-β) signaling pathway, cytokine-cytokine receptor interactions, the p53 signaling pathway, the apoptotic signaling pathway, as well as others...
  76. doi Signal flow and pathways in response to early Wallerian degeneration after rat sciatic nerve injury
    Meiyuan Li
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, PR China
    Neurosci Lett 536:56-63. 2013
    ..KEGG pathway analysis revealed activity mainly relating to cytokine-cytokine receptor interaction, MAPK signaling pathway, Jak-STAT signaling pathway, ErbB signaling pathway and TGF-beta ..
  77. doi A protective role of IL-30 via STAT and ERK signaling pathways in macrophage-mediated inflammation
    Xiao Liu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, PR China
    Biochem Biophys Res Commun 435:306-12. 2013
    IL-30, the p28 subunit of IL-27, interacts with the Epstein-Barr virus-induced gene 3 (EBI3) to form IL-27, which modulates the inflammatory responses in autoimmune and infectious diseases...
  78. pmc Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia
    Shilpa Gandre-Babbe
    Division of Hematology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Blood 121:4925-9. 2013
    ..JMML) is an aggressive myeloproliferative neoplasm of young children initiated by mutations that deregulate cytokine receptor signaling. Studies of JMML are constrained by limited access to patient tissues...
  79. pmc Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations
    B D Green
    Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, Victoria 3052, Australia
    Cell Death Differ 20:1341-9. 2013
    The activation of the Akt signalling in response to cytokine receptor signalling promotes protein synthesis, cellular growth and proliferation...
  80. pmc The retinol esterifying enzyme LRAT supports cell signaling by retinol-binding protein and its receptor STRA6
    Gurdeep Marwarha
    2Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    FASEB J 28:26-34. 2014
    ..STRA6, which serves a dual role: it mediates transport of retinol from RBP into cells, and it functions as a cytokine receptor that, on binding holo-RBP, activates JAK2/STAT5 signaling...
  81. doi Transcriptome sequencing reveals differences between anagen and telogen secondary hair follicle-derived dermal papilla cells of the Cashmere goat (Capra hircus)
    Bing Zhu
    The Key Laboratory of Mammalian Reproductive Biology and Biotechnology of the Ministry of Education, Inner Mongolia University, Hohhot, Peoples Republic of China
    Physiol Genomics 46:104-11. 2014
    ..Orthologous Groups of proteins (KOG) database and in cell cycle, cell adhesion molecules, cytokine-cytokine receptor interaction, and p53 signaling pathway from the Kyoto Encyclopedia of Gene and Genomes (KEGG) database...
  82. doi Role of the interleukin 6 receptor family in epithelial ovarian cancer and its clinical implications
    Janani Kumar
    School of Medicine, Deakin University, Geelong, Victoria, Australia Strategic Research Centre in Molecular and Medical Research, Deakin University, Geelong, Victoria, Australia
    Biochim Biophys Acta 1845:117-25. 2014
    ..b>Cytokine receptor signaling through the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is an ..
  83. pmc Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells
    Seiichi Okabe
    First Department of Internal Medicine, Tokyo Medical University, Shinjuku ku, Tokyo 160 0023, Japan
    J Hematol Oncol 7:37. 2014
    ..Hematopoietic cytokine receptor signaling is mediated by Janus kinases (JAKs) and their downstream transcription factor, signal transducer ..
  84. doi Differentially expressed microRNAs and affected signaling pathways in placentae of transgenic cloned cattle
    Feng jun Liu
    College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China Electronic address
    Theriogenology 82:338-46.e3. 2014
    ..mainly included malaria, nucleotide binding oligomerization domain-like receptor signaling, cytokine-cytokine receptor interaction, Jak-STAT signaling pathway...
  85. doi Detection of CXCR2 cytokine receptor surface expression using immunofluorescence
    Clarissa Lam
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Queens, NY, 11439, USA
    Methods Mol Biol 1172:193-200. 2014
    ..However, this protocol is easily adaptable to analyze the surface expression of other cytokine receptors in different cell types...
  86. pmc T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo
    Nicholas van Panhuys
    Lymphocyte Biology Section, Laboratory of Systems Biology, NIAID, NIH, Bethesda, MD 20892, USA Electronic address
    Immunity 41:63-74. 2014
    ..TCR signal strength controlled downstream cytokine receptor expression, linking the two components in a hierarchical fashion...
  87. doi Cytokine-like molecule CCDC134 contributes to CD8⁺ T-cell effector functions in cancer immunotherapy
    Jing Huang
    Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing, China Peking University Center for Human Disease Genomics, Beijing, China
    Cancer Res 74:5734-45. 2014
    ..through the JAK3-STAT5 pathway, a classic feature of many cytokines of the common γ-chain (γ(c)) cytokine receptor family...
  88. doi IL-35 and Autoimmunity: a Comprehensive Perspective
    Jinjung Choi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, Davis, CA, 95616, USA
    Clin Rev Allergy Immunol 49:327-32. 2015
    ..of a heterodimer of α and β chains, which in the case of IL-35 are the p35 and Epstein-Barr virus-induced gene 3 (EBI3) proteins...
  89. doi Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody
    Shino Ohshima
    Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine
    Biosci Trends 8:308-15. 2014
    CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells with a likely role in cell survival, proliferation and differentiation...
  90. doi CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease
    Stephen I Rennard
    1 University of Nebraska Medical Center, Omaha, Nebraska
    Am J Respir Crit Care Med 191:1001-11. 2015
    An antagonist (MK-7123) of the cytokine receptor CXCR2 reduces neutrophil chemotaxis and thus may alleviate airway inflammation in chronic obstructive pulmonary disease (COPD).
  91. pmc Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines
    Vipin Shankar
    Department of Pediatrics, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie, Japan
    PLoS ONE 10:e0120069. 2015
    ..cell lines, and compared their invasive potential towards MSC-conditioned-RPMI (mRPMI) and their cytokine receptor expression profiles...
  92. doi Interleukin-27, a novel cytokine induced by ischemia-reperfusion injury in rat hearts, mediates cardioprotective effects via the gp130/STAT3 pathway
    Ming Chieh Ma
    School of Medicine, Fu Jen Catholic University, 510 Chungcheng Road, Hsinchuang District, New Taipei, 24205, Taiwan
    Basic Res Cardiol 110:22. 2015
    ..Here, we showed increased expression of mRNA for the IL-27 subunits, EBI3 and p28, in rat hearts after 40 min of coronary ligation and release for 7 days...
  93. doi Clinical Evaluation of ErbB-Targeted CAR T-Cells, Following Intracavity Delivery in Patients with ErbB-Expressing Solid Tumors
    Sophie Papa
    Department of Research Oncology, King s College London, Guy s Hospital, London, UK
    Methods Mol Biol 1317:365-82. 2015
    ..receptor (CAR), T1E28z, targeted against a range of ErbB homodimers and heterodimers and (2) a chimeric cytokine receptor, 4αβ, that allows the selective ex vivo expansion of engineered cells using interleukin-4...
  94. doi Uterine leiomyosarcoma with osteoclast-like giant cells associated with high expression of receptor activator of nuclear factor κB ligand
    Mika Terasaki
    Department of Analytic Human Pathology, Nippon Medical School, Tokyo 113 8602, Japan Electronic address
    Hum Pathol 46:1679-84. 2015
    ..These findings suggest that the tumors producing RANKL may account for accumulation of OLGCs in tumor tissue because of RANKL-related osteoclastogenesis. ..
  95. doi EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin
    Hideo Kudo
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Immunol 195:3565-73. 2015
    ..IL-35 consists of p35 and EBI3 subunits, and EBI3 alone could downregulate the protein and mRNA expression of type I or type III collagen in the ..
  96. doi Denosumab Inhibition of RANKL and Insulin Resistance in Postmenopausal Women with Osteoporosis
    Antonino Lasco
    Department of Clinical and Experimental Medicine, University Hospital of Messina, A O U Policlinico G Martino, Via C Valeria, 98125, Messina, Italy
    Calcif Tissue Int 98:123-8. 2016
    The tumor necrosis factor-related cytokine receptor activator of nuclear factor kappa B ligand (RANKL) has been proposed as predictor of incident type 2 diabetes mellitus, and experimental blockade of RANKL resulted in a marked ..
  97. pmc Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis
    Won Jun Lee
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea
    PLoS ONE 11:e0148818. 2016
    ..This experiment focused on four gene sets such as cytokine-cytokine receptor interaction that demonstrated significance in both datasets...
  98. pmc A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies
    Boris Shulgin
    M and S Decisions LLC, Moscow, Russia
    PLoS ONE 11:e0149154. 2016
    ..Model predictions were in agreement with experimental studies. When the cytokine receptor consists of multiple subunits with substantially differing affinities (e.g...
  99. pmc Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis
    Debarati Mukherjee
    Burnett School of Biomedical Sciences University of Central Florida College of Medicine, Orlando, FL, USA
    Oncotarget 7:23552-68. 2016
    ..Here we report a novel signaling from KLF8 to C-X-C cytokine receptor type 4 (CXCR4) in breast cancer...
  100. pmc Bi-allelic Mutations in KLHL7 Cause a Crisponi/CISS1-like Phenotype Associated with Early-Onset Retinitis Pigmentosa
    Andrea Angius
    Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche CNR, Monserrato, 09042 Cagliari, Italy
    Am J Hum Genet 99:236-45. 2016
    ..CS/CISS1 can be caused by mutations in cytokine receptor-like factor 1 (CRLF1). However, the physiopathological role of CRLF1 is still poorly understood...
  101. doi Investigation of novel LPS-induced differentially expressed long non-coding RNAs in endothelial cells
    Krishna K Singh
    Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science, St Michael s Hospital, 8th Floor, Bond Wing, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Mol Cell Biochem 421:157-68. 2016
    ..analyses indicated that the differentially expressed upregulated mRNAs are primarily enriched in cytokine-cytokine receptor interaction, infectious diseases, TNF signaling pathway, FoxO signaling pathway, and pathways in cancer...

Research Grants65

  1. TIMOTHY L MANSER; Fiscal Year: 2014
    ..We have utilized the NOD/SCID/common cytokine receptor g chain knockout (NSG) strain of mice and human umbilical cord blood (UCB) CD34+ hematopoietic stem cells (..
  2. Margot S Damaser; Fiscal Year: 2014
    ..Specific projects to test stem cell homing as a possible adjuvant to rehabilitative treatments after polytrauma will be developed based on the outcome of the proposed work. ..
  3. Growth Hormone Regulation of SH2-B1
    Christin Carter Su; Fiscal Year: 2009
    ..signaling molecules for growth hormone (GH) receptors (GHR) and the many other members of the cytokine receptor superfamily was a major step forward in our understanding of the cellular basis for GH actions...
  4. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..circulating levels) and tissue (adipose tissue and skeletal muscle) inflammation (secretion, expression, and cytokine receptor TNFR1, TNFR2, adipoR1, adipoR2 expression) are disturbed in chronic stroke compared to age, sex, BMI, race, ..
  5. Effect of a viral replicon adjuvant on dendritic cell activity
    DANIEL TONKIN; Fiscal Year: 2010
    ..by blocking cytokines with antibodies, and also by using DCs from cytokine-knockout mice, or T cells from cytokine receptor knockout mice...
  6. T Cell Homeostasis in Systemic Autoimmunity
    Argyrios N Theofilopoulos; Fiscal Year: 2012
    ..lymphopenic hosts, and inhibition of proliferation by IL-7R-blocking antibodies;b) define the mechanisms of cytokine receptor downregulation and their implications to autoimmunity by determining the dynamic regulation of CD127 and ..
  7. Chronic Pain and Emotional Learning and Memory
    APKAR VANIA APKARIAN; Fiscal Year: 2012
    ..The functional role of cytokines will be studied in persistent pain models, when cytokine receptor antagonist or cytokine blocking adenovectors are injected at specific brain sites...
  8. David M Underhill; Fiscal Year: 2016
    ..While TLR signaling is relatively well-understood and shares much in common with cytokine receptor signaling, we have discovered that Dectin-1 signaling shares much in common with antigen receptor signaling...
  9. Laurence A Turka; Fiscal Year: 2014
    ..This has led us to formulate the hypothesis that PTEN loss disrupts Treg homeostasis due to reduced cytokine receptor expression, altered migration and apparent loss of regulatory capacity...
  10. Stefanie N Vogel; Fiscal Year: 2014
    ..hypothesis to be tested is that activation of specific intracellular signaling pathways distal to TLR and/or cytokine receptor engagement programs expression of discrete cassettes of pro- and anti-inflammatory genes that dictate the ..
  11. Structural biology of shared cytokine signaling receptors
    KENAN CHRISTOPHER GARCIA; Fiscal Year: 2012
    ..These studies will give us insight into basic receptor signaling mechanisms, as well as facilitate the manipulation of the cytokine receptor system for therapeutic purposes.
  12. Nira Ben-Jonathan; Fiscal Year: 2015
    ..abstract_text> ..
  13. Technology for bioactivity based discovery of novel cytokine receptor agonists
    William J Dower; Fiscal Year: 2013
    ..of peptide producing bacteria engineered to express the peptides in a form suitable for direct testing for cytokine receptor activation in ultra-high-throughput formats...
  14. KENAN CHRISTOPHER GARCIA; Fiscal Year: 2016
    ..Finally, in Aim 4, we continue to pursue structural information on how cytokine receptor intracellular segments engage Janus Kinase (JAK) molecules, by reconstituting an entire full-length cytokine ..
  15. Paul J Bryce; Fiscal Year: 2016
    ..Recently, the concept of "modifiers" of cytokine receptor functions has emerged, whereby signals from other receptors can alter those through the cytokine receptor...
  16. Juan Luis Mendoza; Fiscal Year: 2016
    ..abstract_text> ..
  17. Anti-Apoptotic Signaling by the IL-2/15 Receptor
    SARAH GAFFEN; Fiscal Year: 2006
    ..Moreover, genetic deficiencies in certain cytokine receptor components cause several immunodeficiency and/or autoimmune syndromes...
  18. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2010
    ..IL-7 receptor is composed of two different cytokine receptor subunits;the IL-7 receptor alpha chain and the common gamma chain...
  19. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..by osteoclasts (OCs), bone resorbing cells that form under the influence of the key osteoclastogenic cytokine Receptor- Activator of NF-:B (RANKL)...
  20. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark R Boothby; Fiscal Year: 2010
    ..whether or not a common set of signal transduction pathways recruited after T cell activation endows this cytokine receptor with each of its altered functional characteristics...
  21. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..Although tyrosine phosphorylation has long been accepted to play a paramount role in cytokine receptor signal transduction, our findings based upon preliminary data and protein secondary structural analysis ..
  22. Novel Myeloid Cell Transforming Properties of Interleukin-27 Receptor
    Gary W Reuther; Fiscal Year: 2013
    ..studies are to characterize the transforming properties of the receptor for interleukin-27 (IL27R), a type I cytokine receptor, and to determine the contribution of IL27R to the development of leukemia...
  23. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    ..They propose to use IL-1 Trap, a fusion protein consisting of human IL-1 cytokine receptor extracellular domains and the FC portion of human immunoglobulin G (lgG) that binds and neutralizes IL-1...
  24. Cliona M Rooney; Fiscal Year: 2016
    ..cancer by using T cells that are specific for the tumor antigen mesothelin and express a hovel chimeric cytokine receptor (1L4/7), which is expected to promote T-cell expansion and persistence when engaged by inhibitory IL4 signal ..
  25. Xue Zhong Yu; Fiscal Year: 2016
    ....
  26. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark Boothby; Fiscal Year: 2004
    ..To bypass these obstacles, we created a transgenic mouse model in which expression of a chimeric cytokine receptor was targeted to the T lymphoid lineage...
  27. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
    ..nanotubes on specific host receptors, peroxisome proliferator-activated receptor? (PPAR?) and chemotactic cytokine receptor 5 (CCR5), reported to be dysregulated in sarcoidosis lung...
  28. Nancy Speck; Fiscal Year: 2015
    ..We will determine if treatment of mice with an agonist of a cytokine receptor that is under-expressed improves engraftment...
  29. 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental Chemicals
    Akira Takashima; Fiscal Year: 2010
    ..expressing the DsRed gene under the control of Tfec (a transcription factor known to regulate cytokine and cytokine receptor gene expression)...
  30. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2011
    The erythropoietin (Epo) receptor is a model for understanding signal transduction mechanisms of the cytokine receptor superfamily...
  31. Gianpietro Dotti; Fiscal Year: 2014
    ..therapy targeting neuroblastoma (NB) by co-expressing a tumor-specific chimeric antigen receptor (CAR) and a cytokine receptor. NB is the most common malignant extracranial tumor of childhood, and children with high-risk disease ..
  32. Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.
    Rahul Datta; Fiscal Year: 2011
    ..Preliminary data show PARP-1 is involved in the signal transduction pathway of the IL-4 cytokine receptor. Intranasal administration of IL-4 fails to restore eosinophilia to PARP-1 knockout mice, but administration ..
  33. Amelioration of Immune Cell-Mediated Periodontal Disease
    Toshihisa Kawai; Fiscal Year: 2012
    ....
  34. Stuart J Frank; Fiscal Year: 2014
    ..GH receptor (GHR) is a cell surface glycoprotein cytokine receptor superfamily member that binds GH in its extracellular domain (ECD) and activates signaling via its ..
  35. Elizabeth M Gardner; Fiscal Year: 2014
    ..Age-related differences in lytic efficiency, activation receptor function/signaling, and cytokine receptor/function will be measured in purified NK cells to identify intrinsic NK cell defects...
  36. Effect of HIV Infection and HAART on Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2013
    ..Osteoclasts the cells responsible for bone resorption form under the influence of the key osteoclastogenic cytokine Receptor- Activator of NF-:B (RANKL)...
  37. Generation and Regulation of Anti-Viral CD4 T Cells with Cytolytic Potential
    Deborah M Brown; Fiscal Year: 2013
    ..role of IL-2 and inflammatory cytokine signals in CD4 CTL development will be established using cytokine and cytokine receptor knockout mice...
  38. Mechanisms of tumor resistance to anti-HER/ErbB therapeutics
    Zhen Fan; Fiscal Year: 2012
    ..As a member of the type I cytokine receptor family, EpoR homodimerizes upon EPO binding, triggering activation of the receptor-associated kinase Jak2, ..
  39. JULIA THERESE WARREN; Fiscal Year: 2014
    ..and cell polarization for its function, both of which are downstream of signaling through the cytokine receptor activator of NF-kB ligand (RANKL)...
  40. David A Williams; Fiscal Year: 2014
    ..The most common form of SCID is an X-linked form (SCID-X1) caused by defects in the common cytokine receptor ? chain (?c or IL-2RG)...
  41. Opioid Impact on Trim37-Induced Restriction of HIV
    LAUREN BRITTANY BEACH; Fiscal Year: 2013
    ..increases in HIV-1 replication is due to opioids'well-documented ability to modulate cytokine and cytokine receptor signaling and expression...
  42. Eric G Pamer; Fiscal Year: 2016
    ..difficile infection and to discover practicable approaches, such as selective TLR or cytokine receptor stimulation or microbiota manipulation, to re-induce these mechanisms in vulnerable patients.
  43. Jonathan S Maltzman; Fiscal Year: 2014
    ..The relative contribution of TCR signals and cytokine receptor generated signals may vary depending on the nature of the immunogen, however the specific intracellular ..
  44. Barbara Fingleton; Fiscal Year: 2015
    ..Therefore, new therapeutic approaches are urgently needed. This proposal focuses on the role of a cytokine receptor constituent known as IL4Ralpha, specifically when it is expressed on epithelial tumor cells...
  45. James V DeGregori; Fiscal Year: 2016
    ..due to alterations in hematopoietic stem cell lineage bias, 2) ask whether manipulation of inflammation and cytokine receptor signaling in mice can impact on aging-associated reductions in hematopoietic progenitor fitness, oncogenic ..
  46. NORA E SARVETNICK; Fiscal Year: 2016
    ..Therefore, our approach will provide novel findings facilitating clinical trials blocking the IL-18R pathway in new-onset diabetes patients. ..
  47. Structure-function studies of single transmembrane helix receptors
    STEVEN OWEN SMITH; Fiscal Year: 2011
    ..The aim of the research is to establish how receptors in the receptor tyrosine kinase and cytokine receptor families with a single transmembrane sequence transmit information across cell membranes...
  48. DAVID MARC WEINSTOCK; Fiscal Year: 2016
    ..studies is to establish whether precursor B-cell acute lymphoblastic leukemias (B-ALLs) that overexpress the cytokine receptor CRLF2 are dependent on CRLF2 signaling for survival...
  49. Xenograft Model to Study Impact of CRLF2-Ligand in Hispanic Childhood B-ALL
    Kimberly J Payne; Fiscal Year: 2013
    ..Genetic defects resulting in B cells that overexpress the cytokine receptor component, CRLF2, lead to malignant transformation and high-risk CRLF2-d B-ALL with poor prognosis...
  50. Hsing Jien Kung; Fiscal Year: 2016
    ..Src tyrosine kinase (TK) complex as a central integrator of signals emanating from tyrosine kinase receptor, cytokine receptor and G-protein coupled receptor...
  51. Wonpil Im; Fiscal Year: 2014
    ..There is a recent paradigm shift in the mechanism of activation for the cytokine receptor superfamily...
  52. The involvement of IL-12 and IL-27 in immunity to Mycobacterium tuberculosis
    CORY MICHAEL ROBINSON; Fiscal Year: 2013
    ..The third specific aim tests the hypothesis that novel mechanisms operate to control transcription of IL-27 EBI3 and p28 genes...
  53. PKC zeta as a Target for Ceramide
    Mark Kester; Fiscal Year: 2010
    ..These studies will elucidate the biophysical and biochemical mechanisms by which inflammatory cytokine receptor-induced ceramide formation limits cellular proliferation in models of inflammatory vascular diseases...
  54. Greg M Delgoffe; Fiscal Year: 2014
    ..is secreted as a heterodimer of two protein chains, the IL-12 subunit p35 and Epstein-Barr Virus induced gene 3 (Ebi3). IL-35 is a potent inhibitor of immune cell proliferation in vitro and in vivo...
  55. GASTRIC CANCER INDUCED BY H PYLORI IN P27 DEFICIENT MICE
    Steven Moss; Fiscal Year: 2009
    ..pylori virulence determinants and host factors, such as polymorphisms responsible for cytokine and cytokine receptor expression and activity...
  56. T cell immunity and cytokine receptor signaling
    THOMAS MALEK; Fiscal Year: 2009
    ..abstract_text> ..
  57. SRC-LIKE KINASES IN INTERLEUKIN-3 RECEPTOR SIGNALING
    Steven Anderson; Fiscal Year: 2001
    ..mitogenesis, but it is not understood how their activation is regulated or what role they play in cytokine receptor signaling...
  58. ANTIGEN-INDUCED B LYMPHOCYTE DEVELOPMENT
    Douglas Fearon; Fiscal Year: 2006
    ..of SHP-1 in the germinal center B cell is required, and whether this permits signaling through a gamma-c cytokine receptor; 3) whether arrested terminal differentiation by BCL-6 is the basis for B cell memory; 4) whether signaling ..
  59. GENE EXPRESSION IN CTCL PATIENTS IN IL 12 CLINICAL TRIAL
    Louise Showe; Fiscal Year: 2001
    ..The applicant's preliminary studies of cytokine receptor gene expression (IL-12R and IFN-gamma R) in CTCL supports the relationship of SS cells to Th2 cells in six ..
  60. Identification of Biofilm-Induced Staphylococcus aureus Cytokine Receptors
    ARLENE HOOGEWERF; Fiscal Year: 2006
    ..by flow cytometry; co-precipitation, proteomics, and transposon mutagenesis will be used to identify cytokine receptor genes. Transposon mutagenesis or allelic replacement will be used to prepare cytokine receptor mutants...
  61. MOLECULAR MECHANISMS CYTOKINE RECEPTOR SIGNALING
    Stephanie Watowich; Fiscal Year: 2000
    ..of this project are to define the role specific protein:protein oligomerization events play in activation of cytokine receptor signal transduction, and to determine the specificity of Jak and Stat signals in erythroid development...
  62. IL2 RECEPTORS--ANALYSIS OF ASSEMBLY AND SIGNALING
    Warner Greene; Fiscal Year: 1999
    ..chain and will explore at a molecular level both the extracellular and intracellular functions of this key cytokine receptor subunit...
  63. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..protein messengers, and their receptors, in the immune response cascade, the role of cytokine and cytokine receptor gene polymorphisms will be a primary focus of this application, and we will focus on the influence of these ..
  64. MECHANISMS OF PULMONARY FIBROSIS CAUSED BY SILICA
    Gerald Davis; Fiscal Year: 2003
    ..macrophages and target lung fibroblast cell lines isolated from wild-type mice and mutant strains with cytokine receptor deletions...
  65. MOLECULAR PATHWAYS IN MYELOPROLIFERATIVE DISEASE
    George Daley; Fiscal Year: 2002
    ..mutations arise in post-receptor signaling proteins, deregulating mitogenic pathways normally controlled by cytokine receptor signal transduction...