E-cadherin

Summary

Gene Symbol: E-cadherin
Description: cadherin 1
Alias: Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin-1, CAM 120/80, E-cadherin 1, cadherin 1, E-cadherin (epithelial), cadherin 1, type 1, E-cadherin (epithelial), calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, epithelial cadherin, uvomorulin
Species: human

Top Publications

  1. pmc Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
    Richard S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
    Nat Genet 40:1426-35. 2008
  2. ncbi Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
    Yasuyuki Fujita
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
    Nat Cell Biol 4:222-31. 2002
  3. pmc Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:235-41. 2008
  4. pmc A novel role for p120 catenin in E-cadherin function
    Renee C Ireton
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 159:465-76. 2002
  5. ncbi Cadherin switch in tumor progression
    Rachel B Hazan
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 1014:155-63. 2004
  6. doi Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer
    Antoinette Hollestelle
    Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Breast Cancer Res Treat 138:47-57. 2013
  7. ncbi Germline mutations of E-cadherin gene in Korean familial gastric cancer patients
    K A Yoon
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Korea
    J Hum Genet 44:177-80. 1999
  8. pmc The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1
    Ruth Schietke
    Interdisciplinary Centre for Clinical Research, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 285:6658-69. 2010
  9. doi Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells
    J C Cheng
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Oncogene 30:3930-42. 2011
  10. ncbi Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features
    Yu Wei
    Unité de Recombinaison et Expression Génétique INSERM U163, Institut Pasteur, Paris, France
    Hepatology 36:692-701. 2002

Research Grants

  1. James J Hickman; Fiscal Year: 2016
  2. MARY SHARON STACK; Fiscal Year: 2015
  3. A chemical crosslinking strategy to determine DNA methylating protein complexes
    LUCY ANN GODLEY; Fiscal Year: 2010
  4. Promoter Specific Hypermethylation Sensors for Early Cancer Detection
    Indraneel Ghosh; Fiscal Year: 2011
  5. Chou Zen Giam; Fiscal Year: 2014
  6. CHANGYAN CHEN; Fiscal Year: 2016
  7. Characterization of JNK in Cell Cycle Control
    ZE apos EV A RONAI; Fiscal Year: 2012
  8. Mark J Solomon; Fiscal Year: 2016
  9. Direct Detection of Hypermethylation in Cancer
    Indraneel Ghosh; Fiscal Year: 2007
  10. Treating type 2 diabetes with menin inhibitors
    Frank Leu; Fiscal Year: 2013

Detail Information

Publications393 found, 100 shown here

  1. pmc Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
    Richard S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
    Nat Genet 40:1426-35. 2008
    ..1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC...
  2. ncbi Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
    Yasuyuki Fujita
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
    Nat Cell Biol 4:222-31. 2002
    ..Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis...
  3. pmc Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    Farhad Vesuna
    Department of Radiology, Johns Hopkins University School of Medicine, 340 Traylor, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:235-41. 2008
    ..Finally, the functional relevance of this regulation was verified by quantitative real-time PCR and immunohistochemistry on a cohort of breast cancer samples...
  4. pmc A novel role for p120 catenin in E-cadherin function
    Renee C Ireton
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 159:465-76. 2002
    ..These data reveal a cooperative interaction between p120 and E-cadherin and a novel role for p120 that is likely indispensable in normal cells...
  5. ncbi Cadherin switch in tumor progression
    Rachel B Hazan
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 1014:155-63. 2004
    ..Here, we summarize the various aspects of the E- to N-cadherin switching in epithelial carcinomas and its potential impact on metastatic progression...
  6. doi Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer
    Antoinette Hollestelle
    Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Breast Cancer Res Treat 138:47-57. 2013
    ..The discrepancy between E-cadherin loss and EMT was thus reproduced in clinical samples. Together, these results indicate that in human breast cancer loss of E-cadherin is not causal for EMT and even not a necessity...
  7. ncbi Germline mutations of E-cadherin gene in Korean familial gastric cancer patients
    K A Yoon
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Korea
    J Hum Genet 44:177-80. 1999
    ..In summary, we found germline mutations of the E-cadherin gene in two of five Korean familial gastric cancer patients screened...
  8. pmc The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1
    Ruth Schietke
    Interdisciplinary Centre for Clinical Research, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 285:6658-69. 2010
    ..Lysyl oxidases could be an attractive molecular target for cancers of epithelial origin, in particular because they are partly extracellular...
  9. doi Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells
    J C Cheng
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Oncogene 30:3930-42. 2011
    ..Our findings show an important role for p53 in the progression of SBOT to an invasive carcinoma, and suggest that downregulation of E-cadherin by DNMT1-mediated promoter methylation contributes to this process...
  10. ncbi Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features
    Yu Wei
    Unité de Recombinaison et Expression Génétique INSERM U163, Institut Pasteur, Paris, France
    Hepatology 36:692-701. 2002
    ..In conclusion, these data support the notion that E-cadherin might play diverse and seemingly paradoxic roles in HCC, reflecting specific requirements for tumor growth and spread in the liver environment...
  11. doi Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features
    Mahitosh Mandal
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:2088-100. 2008
    ..In the current study, the expressions of several factors associated with the induction of EMT in HNSC cell lines and tumor specimens were investigated to define their functional and pathologic role in HNSC...
  12. pmc Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells
    Karen D Cowden Dahl
    Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA
    Cancer Res 68:4606-13. 2008
    ..These data suggest that regulation of MMP-9 by EGFR may represent a novel mechanism for down-modulation of E-cadherin in ovarian cancer...
  13. pmc p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction
    Jose Piedra
    Unitat de Biofisica, Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Mol Cell Biol 23:2287-97. 2003
    ....
  14. pmc The paradox of E-cadherin: role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism
    Khoi Chu
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Oncotarget 4:446-62. 2013
    ..Our data suggests a novel function for E-Cadherin as a bona fide signaling molecule required for the in vivo growth of aggressive breast cancer tumor cells, that retain E-Cadherin expression, in mediating their metabolic function...
  15. doi E-cadherin and beta-catenin loss of expression related to bone metastasis in prostate cancer
    Jose Pontes
    Laboratory of Medical Investigation LIM 55, Urology Department, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Appl Immunohistochem Mol Morphol 18:179-84. 2010
    ..The aim of this study is to verify the role of adhesion molecules in the progression of prostate cancer (PC), assessing the expression of E-cadherin and beta-catenin in bone metastasis...
  16. doi E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man
    Bostjan Humar
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Cancer Res 69:2050-6. 2009
    ..Together, these findings provide compelling evidence for a deficiency in cell-to-cell adhesion being sufficient to initiate diffuse gastric cancer in the absence of hyperproliferation and beta-catenin activation...
  17. doi Expression of P-aPKC-iota, E-cadherin, and beta-catenin related to invasion and metastasis in hepatocellular carcinoma
    Guang Sheng Du
    Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Ann Surg Oncol 16:1578-86. 2009
    ..Expression of aPKC-iota, P-aPKC-iota (activated aPKC-iota), E-cadherin, and beta-catenin in hepatocellular carcinoma (HCC) was measured, and correlation with clinicopathological characteristics of HCC was analyzed...
  18. doi Activation of STAT3 signal pathway correlates with twist and E-cadherin expression in hepatocellular carcinoma and their clinical significance
    Chuan Hai Zhang
    Graduate School of Tianjin Medical University, Tianjin, People s Republic of China
    J Surg Res 174:120-9. 2012
    ....
  19. pmc Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of EGFR
    Dongsheng Wang
    Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA
    Mol Cancer 10:116. 2011
    ..To understand the biological mechanisms underlying this clinical observation, we knocked down E-cad expression utilizing E-cad siRNA in four SCCHN cell lines...
  20. pmc Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling
    S M Brouxhon
    Department of Emergency Medicine, Health Sciences Center, Stony Brook University, Stony Brook, NY, USA
    Oncogene 33:225-35. 2014
    ....
  21. ncbi p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity
    T Ohkubo
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    J Biol Chem 274:21409-15. 1999
    ..Together, these results indicate that p120(ctn) is a modulator of E-cadherin-mediated cell adhesion...
  22. pmc Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    Tsutomu Imai
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Pathol 163:1437-47. 2003
    ..These findings suggest that hypoxia plays an important role in the change in intercellular attachment, which may be involved in the initiation of tumor progression of ovarian cancer cells...
  23. doi Lef-1 isoforms regulate different target genes and reduce cellular adhesion
    Sarah Jesse
    Department of Internal Medicine I, University of Ulm, D 89081 Ulm, Germany
    Int J Cancer 126:1109-20. 2010
    ..Our findings indicate that expression of alternatively spliced Lef-1 isoforms is involved in the determination of proliferative or migratory characteristics of pancreatic carcinoma cells...
  24. doi Predicting invasive phenotype with CDH1, CDH13, CD44, and TIMP3 gene expression in primary breast cancer
    Aydan Celebiler Cavusoglu
    Department of Basic Oncology, Dokuz Eylul University, Izmir, Turkiye
    Cancer Sci 100:2341-5. 2009
    ..In double-negative tumor tissues, CD44 can be considered a marker for aggressive properties...
  25. doi Fyn mediates transforming growth factor-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells
    An Na Kim
    Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 200 701, Republic of Korea
    Biochem Biophys Res Commun 407:181-4. 2011
    ..Collectively, our findings identify a Fyn-p38-Snail cascade as a new signaling pathway mediating oncogenic TGF-β function...
  26. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ....
  27. ncbi Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 440 PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
    Semin Cell Dev Biol 15:657-63. 2004
    ..Thus, it is possible that the classic observation of E-cadherin-deficiency in metastatic cancer may in some cases be due to p120 downregulation rather than better understood mechanisms acting at the level of E-cadherin transcription...
  28. ncbi The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation
    I R Beavon
    Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa
    Eur J Cancer 36:1607-20. 2000
    ..The interaction of the E-cadherin-catenin complex with various regulating factors, their effect on cell signalling pathways, and the relationship with the metastatic potential of tumours are reviewed...
  29. ncbi DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    Andreas Eger
    Max F Perutz Laboratories, University Department at the Vienna Biocenter, Department of Medical Biochemistry, Medical University Vienna, Vienna, Austria
    Oncogene 24:2375-85. 2005
    ..RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF1 is a key player in late stage carcinogenesis...
  30. doi Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis
    Marion Desclozeaux
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072 Queensland, Australia
    Am J Physiol Cell Physiol 295:C545-56. 2008
    The correct targeting and trafficking of the adherens junction protein epithelial cadherin (E-cadherin) is a major determinant for the acquisition of epithelial cell polarity and for the maintenance of epithelial integrity...
  31. pmc Identification of a physiological E2 module for the human anaphase-promoting complex
    Adam Williamson
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:18213-8. 2009
    ..We conclude that UbcH10 and Ube2S constitute a physiological E2-module for APC/C, the activity of which is required for spindle assembly and cell division...
  32. doi Altered expression of E-cadherin by hepatocyte growth factor and effect on the prognosis of nasopharyngeal carcinoma
    Li Qiong Xie
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Ann Surg Oncol 17:1927-36. 2010
    ..This study investigated HGF-induced altered expression of E-cadherin and the relationship between prognosis and modulation of E-cadherin by HGF in NPC...
  33. doi Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells
    Lauréline Roger
    Universités Montpellier 2 et 1, CRBM, CNRS UMR 5237, 1919 Route de Mende, 34293 Montpellier, France
    J Cell Sci 123:1295-305. 2010
    ..These findings indicate that independent control of E-cadherin expression and cell motility could be essential molecular events in p53 mutant-induced invasive phenotypes...
  34. ncbi The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
    R B Hazan
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 273:9078-84. 1998
    ....
  35. ncbi Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Clin Cancer Res 11:1174-80. 2005
    ..The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in ESCC...
  36. ncbi E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
    K F Becker
    GSF Forschungzentrum für Umwelt und Gesundheit, Institut fur Pathologie, Oberschleissheim, Germany
    Cancer Res 54:3845-52. 1994
    ..Our study provides strong in vivo evidence that E-cadherin gene mutations may contribute to the development of diffusely growing gastric carcinomas and support a tumor/metastasis suppressor gene hypothesis...
  37. ncbi Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn
    Takashi Hoshino
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka 565 0871, Japan
    J Biol Chem 280:24095-103. 2005
    ....
  38. doi E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ....
  39. doi Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis
    Xiaobing Chen
    Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
    Mol Biol Rep 39:6707-14. 2012
    ..Thus, E-cadherin can act as a central modulator of the cell biological phenotypes and a potential prognostic marker in Colorectal cancer...
  40. doi The predictive value of serum soluble E-cadherin levels in breast cancer patients undergoing preoperative systemic chemotherapy
    G Hofmann
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Clin Biochem 46:1585-9. 2013
    ..We, therefore, hypothesized that serum sE-cadherin levels measured before PST may correlate with pathological response...
  41. ncbi Cleavage and shedding of E-cadherin after induction of apoptosis
    U Steinhusen
    Departments of Medical Oncology and Tumorimmunology, Max Delbrück Center of Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    J Biol Chem 276:4972-80. 2001
    ....
  42. ncbi Association of the -160 C --> a promoter polymorphism of E-cadherin gene with gastric carcinoma risk
    Ming Shiang Wu
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Cancer 94:1443-8. 2002
    ..This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...
  43. ncbi CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer
    Paul D P Pharoah
    Department of Oncology, University of Cambridge, Strangeways Research Laboratories, Cambridge, United Kingdom
    Int J Cancer 101:196-7. 2002
    ..3 (95% CI 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffuse-type histopathologic subgroups...
  44. ncbi Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer
    Bostjan Humar
    Cancer Genetics Laboratory, University of Otago, Dunedin, Aotearoa, New Zealand
    Oncogene 21:8192-5. 2002
    ..004). However, this analysis suggested the -160C-->A CDH1 promoter polymorphism may be in linkage disequilibrium with a distinct aetiological locus or acts in combination with other functional variants in or near the CDH1 region...
  45. pmc A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer
    Won Sang Park
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Korean Med Sci 18:501-4. 2003
    ..These results suggest that the -160 C/A polymorphism of the E-cadherin has no direct effect on the risk of Korean gastric cancer development and on its histological classification...
  46. pmc E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population
    Yan Lu
    Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 11:56-60. 2005
    ..To test the hypothesis that E-cadherin gene (CDH1) C-160A promoter variant genotype is associated with an increased risk for developing gastric cancer...
  47. ncbi Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion
    Kiyono Shiraishi
    Project Research Laboratory, Research Center for Genomic Medicine, Saitama Medical Center, Saitama Medical School, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Immunol 175:1014-21. 2005
    ....
  48. ncbi Functional analysis and case-control study of -160C/A polymorphism in the E-cadherin gene promoter: association with cancer risk
    Francesca Cattaneo
    Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy
    Anticancer Res 26:4627-32. 2006
    ..Due to the crucial role of E-cadherin in epithelia, tissue-specific effect of C-->A change on CDH1 transcription was tested and a case-control study was performed on patients affected with epithelial tumors...
  49. ncbi Single nucleotide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: case-control study in a young Mexican population
    Heriberto Medina-Franco
    Department of Surgery, Section of Surgical Oncology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, Colonia Seccion XVI, Tlalpan, Mexico City, Mexico
    Ann Surg Oncol 14:2246-9. 2007
    ..We evaluated the role of the -160A allele in the risk of gastric cancer in a young Mexican population...
  50. ncbi The E-cadherin gene polymorphism 160C->A and cancer risk: A HuGE review and meta-analysis of 26 case-control studies
    Gui Ying Wang
    Laboratory of Population and Quantitative Genetics, Institute of Genetics and Biostatistics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Am J Epidemiol 167:7-14. 2008
    ..These findings indicate that -160A of the E-cadherin gene is emerging as a low-penetrance tumor susceptibility allele for the development of gastric, lung, prostate, and urothelial cancers...
  51. doi Meta-analysis: tumour invasion-related genetic polymorphisms and gastric cancer susceptibility
    L Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Aliment Pharmacol Ther 28:565-73. 2008
    ..Host genetic susceptibility has been suggested as one of the most important possible explanations for interindividual difference in gastric cancer (GC) risk...
  52. doi CDH1 C-160A promoter polymorphism and gastric cancer risk
    Giovanni Corso
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, Translational Research Laboratory, Istituto Toscano Tumori, University of Siena, Siena, Italy
    Eur J Cancer Prev 18:46-9. 2009
    ..Similarly, genotype was not associated with intestinal or diffuse histotypes, or with cardia or noncardia carcinomas. In conclusion, the C-160A polymorphism is not associated with GC risk in the Italian population...
  53. doi p120ctn isoform 1 expression significantly correlates with abnormal expression of E-cadherin and poor survival of lung cancer patients
    Yuan Miao
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, 110001, Shenyang, China
    Med Oncol 27:880-6. 2010
    ..Over-expression of p120ctn isoform 1 positively correlated with poor prognosis of lung cancer patients, and therefore may be a useful marker of lung cancer patient survival...
  54. doi Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer
    L W T Cheung
    School of Biological Sciences, University of Hong Kong, Hong Kong, PR China
    Oncogene 29:2427-40. 2010
    ..These results identify for the first time cadherin switching and p120(ctn) signaling as important targets of GnRH function and as novel mediators of invasiveness and tumor progression in ovarian cancer...
  55. pmc Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk
    Mansour S Al-Moundhri
    Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Muscat 123, Sultanate of Oman
    World J Gastroenterol 16:3432-6. 2010
    ..To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition...
  56. pmc Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis
    Wei Jie Zhou
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Res 21:609-26. 2011
    ..We conclude that engagement of Robo1 by Slit2 induces malignant transformation through Hakai-mediated E-cad ubiquitination and lysosomal degradation during colorectal epithelial cell carcinogenesis...
  57. doi Nuclear localization of E-cadherin but not beta-catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stroma
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Histopathology 58:423-32. 2011
    ..The aim of this study was to confirm subcellular localization of key molecules of Wnt signalling (beta-catenin and E-cadherin) in human ovarian GCTs...
  58. doi E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids
    D Ierodiakonou
    Dept of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Respir J 38:1044-52. 2011
    ..These effects are modified by the use of inhaled corticosteroids...
  59. pmc Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells
    Gagan Deep
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, USA
    Cancer Prev Res (Phila) 4:1222-32. 2011
    ....
  60. doi CDH1 gene polymorphisms, plasma CDH1 levels and risk of gastric cancer in a Chinese population
    Zhen Zhan
    Discipline of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Mol Biol Rep 39:8107-13. 2012
    ..Further studies are warranted to verify these findings...
  61. ncbi E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V
    Salomé S Pinho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Biochim Biophys Acta 1830:2690-700. 2013
    ..We have previously demonstrated the existence of a bi-directional cross-talk between E-cadherin and two major N-glycan processing enzymes, N-acetylglucosaminyltransferase-III or -V (GnT-III or GnT-V)...
  62. doi CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study
    Patrick R Benusiglio
    Consultation d Oncogénétique, Departement de Medecine Oncologique, Institut Gustave Roussy, 114 rue Edouard Vaillant, Villejuif 94805, France
    J Med Genet 50:486-9. 2013
    ....
  63. doi Expression of E-cadherin, Twist, and p53 and their prognostic value in patients with oral squamous cell carcinoma
    Chi Chen Fan
    Laboratory of Physiology, Mackay Memorial Hospital, Taipei, Taiwan
    J Cancer Res Clin Oncol 139:1735-44. 2013
    ..In this study, we aimed to determine the levels of E-cadherin, Twist, and p53 in tumor tissues from patients with oral squamous cell carcinoma (OSCC) and their clinical significances...
  64. pmc Beta-catenin mediates alteration in cell proliferation, motility and invasion of prostate cancer cells by differential expression of E-cadherin and protein kinase D1
    Viqar Syed
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 104:82-95. 2008
    ..This study establishes the functional significance of combined dysregulation of PKD1 and E-cadherin in PC and that their effect on cell growth is mediated by beta-catenin...
  65. doi Possible regulatory role of Snail in NF-κB-mediated changes in E-cadherin in gastric cancer
    Zenan Hu
    First Clinical Medical School of Lanzhou University, Lanzhou 730000, PR China
    Oncol Rep 29:993-1000. 2013
    ..Further studies may reveal whether targeting the NF-κB-Snail-E-cadherin axis could be a useful approach for combating gastric cancer...
  66. ncbi Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma
    Yvonne Chung
    Division of Esophageal Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Ann Surg Oncol 14:3260-7. 2007
    ..Dysregulated expression and mislocalization of p120ctn affect the protective function of the complex. The objective of the present study was to evaluate the clinical significance of E-cadherin and p120ctn expression in ESCC...
  67. doi Nuclear translocation of β-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression?
    Markus Stenner
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
    Histopathology 58:1117-26. 2011
    ..High-risk human papillomaviruses (HPVs) constitute an important risk factor for tonsillar cancer. This study describes changes in cell adhesion molecules during metastasis of HPV-related and HPV-unrelated tonsillar carcinomas...
  68. pmc The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea
    H C Kim
    Cancer and Immunogenetics Laboratory, Imperial Cancer Research Fund, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Gut 47:262-7. 2000
    ..Germline mutations in E-cadherin (CDH1) have been reported in families with early onset, diffuse gastric cancer. More recently, mutations in CDH1 have been described in colorectal cancer cell lines...
  69. ncbi A germline E-cadherin mutation in a family with gastric and colon cancer
    S Salahshor
    Department of Molecular Medicine, Karolinska Institute, S 171 76 Stockholm, Sweden
    Int J Mol Med 8:439-43. 2001
    ....
  70. ncbi Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation
    Subhas Chakrabarty
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:67-71. 2003
    ..In addition, the promotion of E-cadherin and suppression of beta-catenin/T cell factor may be an important mechanism underlying the chemopreventive action of Ca(2+) in colon cancer...
  71. ncbi Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin
    Andrew D Paterson
    School for Biomedical Science, The University of Queensland, St Lucia, Brisbane, Australia 4072
    J Biol Chem 278:21050-7. 2003
    ..Taken with earlier reports, this suggests the possibility that multiple pathways exist for E-cadherin entry into cells that are likely to reflect cell context and regulation...
  72. pmc Endocytosis is required for E-cadherin redistribution at mature adherens junctions
    Simon de Beco
    Centre de Recherche, Institut Curie, F 75248 Paris, France
    Proc Natl Acad Sci U S A 106:7010-5. 2009
    ..Our results point to the possibility that a direct mechanical coupling between endocytosis efficiency and cadherin-mediated forces at junctions could help to regulate intercellular adhesion and locally stabilize epithelia...
  73. doi Genetic and protein changes of E-cadherin in meningiomas
    Nives Pecina-Slaus
    Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Croatia
    J Cancer Res Clin Oncol 136:695-702. 2010
    ..The molecular mechanisms and candidate genes involved in development of meningiomas still needs investigation and elucidation...
  74. doi Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome
    Lai Kui Liu
    Department of Oral Pathology, College of Stomatology, Nanjing Medical University, Jiangsu 210029, China
    Mod Pathol 23:213-24. 2010
    ..The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma...
  75. pmc Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer
    Masatsugu Hiraki
    Department of Surgery, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    World J Gastroenterol 16:330-8. 2010
    ..To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients...
  76. ncbi Methylation status of CDH1 gene in samples of gastric mucous from Brazilian patients with chronic gastritis infected by Helicobacter pylori
    Erika Kague
    Hemocentro, Faculdade de Medicina, UNESP, Botucatu, SP, Brazil
    Arq Gastroenterol 47:7-12. 2010
    ..The inactivation of this gene can increase the chance of metastasis. Promoter methylation of CDH1 at early steps of gastric carcinogenesis is not yet completely understood...
  77. pmc Regulation of Skp2 levels by the Pim-1 protein kinase
    Bo Cen
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:29128-37. 2010
    ..Consistent with these observations, we show that Pim-1 is able to cooperate with Skp2 to signal S phase entry. Our data reveal a novel Pim-1 kinase-dependent signaling pathway that plays a crucial role in cell cycle regulation...
  78. pmc E-cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation
    Il Je Cho
    Innovative Drug Research Center for Metabolic and Inflammatory Disease, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
    Hepatology 52:2053-64. 2010
    ..Liver fibrosis is accompanied by the loss of E-cadherin (ECAD), which promotes the process of epithelial-mesenchymal transition...
  79. doi Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Clin Cancer Res 16:5654-63. 2010
    ..Foxo3a is a member of the Foxo transcription factor family that modulates the expression of various genes. We aimed to elucidate the role of Foxo3a in UC invasion...
  80. ncbi E-cadherin polymorphisms and haplotypes influence risk for prostate cancer
    Carolina Bonilla
    Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
    Prostate 66:546-56. 2006
    ..Several polymorphisms, such as the C/A variant -160 base pairs from the transcription start site, in the CDH1 gene promoter region have been associated with cancer risk, mainly in European descent populations...
  81. pmc Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer
    Hugo Pinheiro
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Porto 4200 465, Portugal
    Hum Mol Genet 19:943-52. 2010
    ..Germline CDH1 AI is highly frequent among CDH1 mutation-negative probands but was not seen in cancer-free individuals. This implicates the CDH1 locus in the majority of mutation-negative HDGC families...
  82. ncbi [Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal carcinoma cells]
    Zhi Li
    Department of Pathology, Sun Yat sen Medical College, Zhong Shan University, Guangzhou 510089, China
    Zhonghua Zhong Liu Za Zhi 25:238-42. 2003
    ..To study the mechanism of invasion and metastasis in early nasopharyngeal carcinoma (NPC) in relation to E-cadherin promoter methylation and mutation in exon 3 of beta-catenin...
  83. ncbi The E-cadherin -347G->GA promoter polymorphism and its effect on transcriptional regulation
    Yong Shin
    Korean Hereditary Tumor Registry, Cancer Research Center and Cancer Research Institute, Seoul National University, South Korea
    Carcinogenesis 25:895-9. 2004
    ..05) compared with the G homozygous genotype. Taken together, these results suggest that the GA allele may cause weak transcription factor binding affinity and low transcriptional activity in E-cadherin expression...
  84. pmc E-cadherin suppression directs cytoskeletal rearrangement and intraepithelial tumor cell migration in 3D human skin equivalents
    Addy Alt-Holland
    Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine Tufts University, Boston, Massachusetts 02111, USA
    J Invest Dermatol 128:2498-507. 2008
    ..Thus, loss of E-cadherin-mediated adhesion led to the acquisition of phenotypic properties that augmented cell motility and directed the transition from the precancer to cancer in skin-like tissues...
  85. doi Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions
    Andrezza C N Barcelos
    Department of Dermatology, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    J Cutan Pathol 36:647-54. 2009
    ..Epidermodysplasia verruciformis (EV) is a rare genodermatosis with susceptibility to human papillomavirus (HPV) infection, and high risk of skin cancer considered a model of viral oncogenesis...
  86. doi Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms
    Mariangela Greco
    Istituto di Ematologia, Universita Cattolica del Sacro Cuore, Roma, Italy
    Blood Cells Mol Dis 45:181-5. 2010
    ....
  87. pmc The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane
    Yuri Fukumoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Exp Cell Res 314:52-67. 2008
    ..These data suggest that serine/threonine phosphorylation of p120 influences the dynamics of E-cadherin in junctions...
  88. ncbi Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/beta-catenin complex
    Ha Na Choi
    Department of Pathology, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonbuk 561 756, Korea
    Oncol Rep 21:57-63. 2009
    ..These results indicate that overexpression of SRF in colorectal carcinoma cells is associated with modulation of E-cadherin/beta-catenin expression and may play an important role in colorectal cancer metastasis...
  89. pmc p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells
    Sandra Kümper
    Randall Division of Cell and Molecular Biophysics, King s College London, London, United Kingdom
    PLoS ONE 5:e11801. 2010
    ..p120ctn is known to regulate cell-cell adhesion by increasing cadherin stability, but the effects of other adherens junction components on cell-cell adhesion have not been compared with that of p120ctn...
  90. ncbi The ins and outs of E-cadherin trafficking
    David M Bryant
    Institute for Molecular Bioscience and School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    Trends Cell Biol 14:427-34. 2004
    ....
  91. ncbi Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene
    H More
    Cancer Genetics Laboratory, University of Otago, Dunedin, Aotearoa, New Zealand
    Hum Mutat 28:203. 2007
    ..Together with the occurrence of extra-gastric tumours such as lobular breast and colorectal cancer, these findings further extend the types of CDH1 mutations and the spectrum of tumours associated with HDGC...
  92. doi Proteolysis of CDH1 enhances susceptibility to UV radiation-induced apoptosis
    Weijun Liu
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    Carcinogenesis 29:263-72. 2008
    ..The present results unveil a novel role for the APC in UV-induced cell death and demonstrate a new regulatory mechanism for APC/CDH1 through proteolysis...
  93. pmc Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis
    Yan Nian Liu
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Mol Cell Biol 28:7096-108. 2008
    ..These results suggest that, similarly to Snail and Twist, the activated AR can downregulate E-cadherin expression to promote the activation of epithelial-mesenchymal transition and tumor metastasis...
  94. pmc Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane
    Tianhui Hu
    Cancer Research Center, Xiamen University Medical College, Xiamen, 361005 Fujian, China
    J Biol Chem 285:13561-8. 2010
    ..These results provide a mechanism by which NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation...
  95. doi The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  96. ncbi E-cadherin-catenin cell-cell adhesion complex and human cancer
    B P Wijnhoven
    Departments of Surgery and Pathology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Br J Surg 87:992-1005. 2000
    ..Recently, much progress has been made in understanding the interaction between the different components of this protein complex and how this cell-cell adhesion complex is modulated in cancer cells...
  97. ncbi Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred
    Carla Oliveira
    Cancer Genomics Program, Department of Oncology, University of Cambridge, Hutchison MRC Research Centre, Addenbrooke s Hospital, Cambridge, UK
    Hum Mutat 19:510-7. 2002
    ..These results add support to the evidence that only HDGC families harbor germline mutations in CDH1 and that genes other than CDH1 remain to be identified...
  98. ncbi Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer
    Y Imamichi
    Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany
    Oncogene 26:2381-5. 2007
    ..Taken together, these results suggest that SIP1 is involved in the progression of pancreatic cancer and plays a role in mediating signal transduction from collagen type I to downregulate E-cadherin expression...
  99. doi Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer
    Joana Simões-Correia
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Hum Mol Genet 17:3566-76. 2008
    ..We show that ERQC plays a major role in E-cadherin regulation and propose that overcoming this regulation may represent an approach to rescue E-cadherin expression and functionality in cancer...
  100. doi Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer
    Giovanni Corso
    University of Siena and Instituto Toscano Tumori, Italy
    J Clin Oncol 31:868-75. 2013
    ..Surgery remains the primary option in GC treatment. The aim of this study was to investigate the impact of somatic CDH1 alterations in prognosis and survival of patients with GC...
  101. ncbi Integrin-mediated functional polarization of Caco-2 cells through E-cadherin--actin complexes
    Cyrille Schreider
    INSERM U505, Universite Pierre et Marie Curie, EPHE, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Cell Sci 115:543-52. 2002
    ....

Research Grants76

  1. James J Hickman; Fiscal Year: 2016
    ....
  2. MARY SHARON STACK; Fiscal Year: 2015
    ..soluble microenvironmental regulators EGF and lysophosphatidic acid (LPA) in regulation of epithelial (E)-cadherin (Ecad) expression and function...
  3. A chemical crosslinking strategy to determine DNA methylating protein complexes
    LUCY ANN GODLEY; Fiscal Year: 2010
    ..In addition, the new chemistry allows formation of DNMT-DNA complexes at high efficiency, which could facilitate the structural characterization of human DNMT-DNA complexes. ..
  4. Promoter Specific Hypermethylation Sensors for Early Cancer Detection
    Indraneel Ghosh; Fiscal Year: 2011
    ..This approach if successful will rapidly distinguish between normal and cancerous tissues in a clinical setting without the requirement for bisulfite treatment, PCR amplification, and sequencing. ..
  5. Chou Zen Giam; Fiscal Year: 2014
    ..The study will provide molecular insights that can lead to the development of treatment strategies for human cancer. ..
  6. CHANGYAN CHEN; Fiscal Year: 2016
    ....
  7. Characterization of JNK in Cell Cycle Control
    ZE apos EV A RONAI; Fiscal Year: 2012
    ..Using biochemical, cellular and genetic models our proposed studies will delineate the requirements and regulation of this newly identified regulatory lobe along the cell cycle and DNA damage response. ..
  8. Mark J Solomon; Fiscal Year: 2016
    ..Our studies will further our understanding of this essential cell cycle regulatory process and, in the longer term, provide targets for therapeutic intervention, directed towards the APC itself or the DUBs acting on its substrates. ..
  9. Direct Detection of Hypermethylation in Cancer
    Indraneel Ghosh; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Treating type 2 diabetes with menin inhibitors
    Frank Leu; Fiscal Year: 2013
    ..These compounds will represent a new class of anti-diabetic drugs, orally administered, negating the need for repeated injections of exogenous insulin in the 17 million US patients diagnosed with T2D. ..
  11. Neuronal CDh1 Regulation and Involvement in Synaptic Plasticity and Memory
    Joseph E Pick; Fiscal Year: 2011
    ..Understanding both the regulatory mechanism of Cdh1 and its involvement in plasticity and memory will allow new therapeutic targets to prevent the onset of Alzheimer's disease ..
  12. Disabling of the Anaphase Promoting Complex by Human Cytomegalovirus
    DEBORAH HYE SPECTOR; Fiscal Year: 2010
    ..The serious problems associated with HCMV infections have provided a major impetus for understanding the molecular and cellular biology of the virus and the regulatory pathways governing its replication and interactions with the host. ..
  13. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
    ..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
  14. Wenyi Wei; Fiscal Year: 2015
    ..Our proposed studies will provide new insight into the signaling pathways controlling Mdm2 destruction. It also provides the rationale for developing CKI and ATM agonists as anti-cancer agents. ..
  15. BEVERLY MARIE EMERSON; Fiscal Year: 2015
    ....
  16. Wenyi Wei; Fiscal Year: 2016
    ..abstract_text> ..
  17. Pseudosubstrate Inhibition of the Anaphase Promoting Complex
    Mark J Solomon; Fiscal Year: 2010
    ..2) To use genetic screens to identify novel human and yeast pseudosubstrate APC inhibitors. We will also further explore the mechanism by which the vertebrate Emi1 protein acts as a pseudosubstrate inhibitor. ..
  18. Pumin Zhang; Fiscal Year: 2015
    ..The work proposed here will shed new light on DNA damage repair, a process essential for human health. ..
  19. Mauricio J Reginato; Fiscal Year: 2015
    ..These studies will further our understanding of how metabolic reprogramming in cancer cells connects at the molecular level to cell growth and survival pathways and identify novel anticancer agents. ..
  20. Yong Wan; Fiscal Year: 2015
    ....
  21. Mechanisms of WNT7A-FGF1 signaling and their therapeutic potential in ovarian can
    Kanako Hayashi; Fiscal Year: 2013
    ....
  22. Anaphase Promoting Complex-mediated Proteolysis
    Mark Solomon; Fiscal Year: 2009
    ..Understanding this degradation is thus important for understanding normal cell proliferation, and how this process goes awry in disease states, particularly cancers. ..
  23. ECAD:Enhanced Coronary Artery Disease Phantom for MRA
    Thomas Burke; Fiscal Year: 2006
    ..We propose to develop an enhanced Coronary Artery Disease (eCAD) phantom for use by MR researchers, developers and medical equipment manufacturers, eCAD combines advanced features ..
  24. UBIQUITIN-MEDIATED CIRCUITRY IN GENOMIC INTEGRITY
    Yong Wan; Fiscal Year: 2006
    ..abstract_text> ..
  25. Regulation of cyclosome/APC in the human cell cycle
    Avram Hershko; Fiscal Year: 2005
    ..abstract_text> ..
  26. ECAD: Enhanced Coronary Artery Disease Phantom for MRA
    Thomas Burke; Fiscal Year: 2001
    ..We propose to develop an enhanced Coronary Artery Disease (eCAD) phantom for use by MR researchers and developers...
  27. Activation of APC by TGF-beta Suppresses Breast Cancer
    Yong Wan; Fiscal Year: 2009
    ..abstract_text> ..
  28. Mitotic Checkpoint & Genomic Stability in Ovarian Cancer
    Dong Yan Jin; Fiscal Year: 2006
    ..Further elucidation of the causative roles of checkpoint defects for drug resistance will reveal novel strategies for combination therapy. [unreadable] [unreadable]..
  29. How do cyclins drive the cell cycle?
    Frederick R Cross; Fiscal Year: 2010
    ..Overall, we are interested in regulation of cell cycle dynamics, and in cyclin-specific pathways promoting individual cell cycle events. ..
  30. VASCULAR DISEASE--STRUCTURE/FUNCTION
    JOHN CROUSE; Fiscal Year: 1999
    ..order to additionally evaluate the associations of all these factors with extracranial carotid arterial dimensions (ECAD: interadventitial and lumen diameters) and change in ECAD over time...
  31. ADHESION RELATED PROTEINS OF HUMAN EPITHELIAL CELLS
    Margaret Wheelock; Fiscal Year: 1991
    ..When clones are identified as specific for cell-CAM 120/80, they will be used in sequence analysis as well as analysis of the expression of this important cell adhesion molecule and analysis of the genes encoding it...
  32. Genetic and Epigenetic Markers in Ovarian Cancer
    Elizabeth Swisher; Fiscal Year: 2006
    ..These studies may identify new prognostic or diagnostic markers in ovarian cancer. Such markers could then be tested in prospective trials to determine their clinical utility. ..
  33. Multiplex approach to DNA methylation assays in exhaled breath condensate
    Weiguo Han; Fiscal Year: 2009
    ....
  34. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  35. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  36. CONTROL OF THE DIFFERENTIATION OF LENS FIBER CELLS
    Pumin Zhang; Fiscal Year: 2004
    ..Exploration on p57's function during lens development will certainly provide some answers to the questions posted above and may shed fresh light on the cause and prevention of cataracts. ..
  37. Notch Signaling and Lens Development
    Pumin Zhang; Fiscal Year: 2010
    ..We will validate this initial finding with in vitro and in vivo experiments. ..
  38. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..
  39. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  40. Protein Interactions of the Germ Cell Kinase Haspin
    JONATHAN HIGGINS; Fiscal Year: 2004
    ..abstract_text> ..
  41. Influence of Tumor Immunogenicity to Immunotherapy
    Jeffrey Norton; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  42. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009
    ..The proposed research should elucidate new aspects of long-distance control of gene expression as well as lending clinically useful insights into this currently intractable disease. ..
  43. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
    ..The proposed research should help elucidate the molecular etiology of the enigmatic FSHD syndrome. ..
  44. P38, G2 Arrest, and Temozolomide Resistance in Gliomas
    RUSSELL PIEPER; Fiscal Year: 2008
    ....
  45. Development of a haspin kinase assay for high throughput drug screening
    JONATHAN HIGGINS; Fiscal Year: 2008
    ..Furthermore, such inhibitors will provide an excellent way to validate haspin as a target for cancer treatment, and they might find direct application as chemotherapeutic drugs. [unreadable] [unreadable] [unreadable]..
  46. RAPAMYCIN BLOCKADE OF PROTEIN PHOSPHATASE SIGNALING
    DAVID BRAUTIGAN; Fiscal Year: 2007
    ..The proposed studies will give new insights into an under-studied phosphatase-signaling pathway and provide information on the molecular basis for action of and resistance to rapamycin. ..
  47. Damage to thymic stroma & de novo T cell production.
    Susan Prockop; Fiscal Year: 2006
    ..Such a setting provides a scientific and clinical basis from which to launch an academic career. [unreadable] [unreadable]..
  48. CELL/CELL APPOSITION AND INFLAMMATORY EDEMA
    D SHASBY; Fiscal Year: 2002
    ..We will use the transfected cells to examine effects of mutations in the cadherins on regulation of adherens junction function, which we can measure in real time. ..
  49. ISOLATION OF A SECOND WILMS TUMOR SUPPRESSOR GENE
    Bernard Weissman; Fiscal Year: 2001
    ....
  50. Development of Digital SNP Analysis in Cancer Detection
    Ie Ming Shih; Fiscal Year: 2005
    ..Thus, the encouraging results from this study will ensure the detection of AI in plasma a promising cancer research direction for further exploration. ..
  51. MECHANISMS OF INFLAMMATORY EDEMA
    DOUGLAS SHASBY; Fiscal Year: 2005
    ..We will use this model to determine if histamine alters cadherin-based adhesion due to effects within the cadherin-catenin complex. ..
  52. EXPRESSION AND SILENCING OF CPG ISLAND-CONTAINING GENES
    Russ Pieper; Fiscal Year: 2001
    ....
  53. TRIGGERING OF ABERRANT CPG ISLAND METHYLATION
    Russ Pieper; Fiscal Year: 2002
    ..These studies represent a first step in understanding the gene silencing process and will ultimately contribute to the development of therapies addressed at controlling gene expression. ..
  54. Mechanisms of N-Cadherin Mediated Breast CA Metastasis
    Rachel Hazan; Fiscal Year: 2005
    ..abstract_text> ..
  55. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    ..protective factors in breast milk, and provide the basis for further characterization of the mechanisms involved in mucosal protection by breast milk, and their role in preventing neonatal gastrointestinal diseases ..
  56. Improving genomic prediction models in breast cancer
    John Olson; Fiscal Year: 2005
    ....
  57. Function of the chromosomal kinase haspin in mitosis
    JONATHAN M HIGGINS; Fiscal Year: 2010
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
  58. SWI/SNF complex loss facilitates gene silencing during NSCLC development
    Bernard E Weissman; Fiscal Year: 2010
    ..abstract_text> ..
  59. Genetic Association Study in African-American Colorectal Cancer Patients
    SONIA KUPFER; Fiscal Year: 2008
    ..The goal of our study is to better understand hereditary factors that increase risk especially in African-Americans who have the highest incidence and death from this cancer. [unreadable] [unreadable] [unreadable]..
  60. SWI/SNF Chromatin Remodeling Loss and Human Cancer
    Bernard Weissman; Fiscal Year: 2007
    ..abstract_text> ..
  61. The Role of MicroRNA in Hepatocarcinogenesis
    Kalpana Ghoshal; Fiscal Year: 2007
    ..Further, this proposal fits well with the mission/goals set forth by multiple institutes that include NCI, NIDDK and NIAAA n the etiology, prevention and treatment of hepatocellular carcinomas. [unreadable] [unreadable] [unreadable]..
  62. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  63. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  64. Prognostic Markers for Juvenile Pilocytic Astrocytomas
    Kwong Kwok Wong; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  65. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  66. Developing Biomarker-Based Prognostics In Breast Cancer
    John Olson; Fiscal Year: 2008
    ..abstract_text> ..
  67. The role of PIKE-S in mediating EGFR mitogenic signaling in OSCC cells
    Zhongjian Xie; Fiscal Year: 2008
    ..Understanding these mechanisms will bring the possibility of new molecular targets for development novel therapeutic options for the control of oral squamous cell carcinoma. [unreadable] [unreadable] [unreadable]..
  68. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  69. Novel Therapeutic Strategies for PKD
    Patricia Wilson; Fiscal Year: 2007
    ..abstract_text> ..
  70. Triple threat screening for modifiers of Protein Ser/Thr Phosphatase 2C
    DAVID BRAUTIGAN; Fiscal Year: 2008
    ..Chemical modifiers of PP2C have potential medicinal applications and will be used as research tools to study signaling in normal and cancer cells. [unreadable] [unreadable] [unreadable]..
  71. Motif-based elucidation of protein modification codes
    JONATHAN HIGGINS; Fiscal Year: 2006
    ..The development of methodology to determine the functional impact of these marks is therefore a critical requirement for future work in all areas of biomedicine. [unreadable] [unreadable]..
  72. CHROMIUM ENHANCEMENT OF INSULIN SIGNALING
    DAVID BRAUTIGAN; Fiscal Year: 2006
    ..abstract_text> ..
  73. UNDERSTANDING TRAIL SENSITIVITY IN HUMAN GLIOMA
    Russell O Pieper; Fiscal Year: 2010
    ..This work has relevance to public health in that it will provide the ways to identify TRAIL-sensitive brain tumors and also to make TRAIL-resistant tumors sensitive to TRAIL-induced killing. ..
  74. Contributions of Akt to Glioblastoma Formation
    RUSSELL PIEPER; Fiscal Year: 2006
    ..Defining Akt function may help identify targets useful in GBM therapy. ..
  75. MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMEL
    John Bartlett; Fiscal Year: 2006
    ..This application builds on results from a highly productive R29 grant (DE12098). ..